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TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These results suggest a novel site of action for potentiation of @CHEM-GENE$ by small molecules and implicate the pre-M1 region in NMDA receptor gating. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These results suggest a novel site of action for potentiation of @CHEMICAL$ receptors by small molecules and implicate the pre-M1 region in @GENE$ gating. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These results suggest a novel site of action for potentiation of @CHEMICAL$ by small molecules and implicate the pre-M1 region in @GENE$ receptor gating. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These results suggest a novel site of action for potentiation of NMDA receptors by small molecules and implicate the pre-M1 region in @CHEM-GENE$ gating. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Association of @CHEM-GENE$ variants with the risk of Alzheimer's disease. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEM-GENE$ (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (@GENE$), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ (ALT), @GENE$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (@CHEMICAL$), @GENE$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), @CHEMICAL$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), @CHEMICAL$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), @CHEMICAL$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), @CHEMICAL$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), @CHEMICAL$ (TG), malondialdehyde (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ (ALT), triglyceride (TG), @GENE$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (@CHEMICAL$), triglyceride (TG), @GENE$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), @CHEMICAL$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), @CHEMICAL$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), @CHEMICAL$ (MDA), and reduced glutathione (GSH); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), @CHEMICAL$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), @CHEMICAL$ (MDA), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ (ALT), triglyceride (TG), malondialdehyde (@GENE$), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (@CHEMICAL$), triglyceride (TG), malondialdehyde (@GENE$), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (@CHEMICAL$), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (@CHEMICAL$), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (@CHEMICAL$), and reduced glutathione (GSH); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (@CHEMICAL$), and reduced glutathione (GSH); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (@CHEMICAL$), and reduced glutathione (GSH); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ (ALT), triglyceride (TG), malondialdehyde (MDA), and @GENE$ (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (@CHEMICAL$), triglyceride (TG), malondialdehyde (MDA), and @GENE$ (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and @CHEMICAL$ (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and @CHEMICAL$ (GSH); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and @CHEMICAL$ (GSH); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and @CHEMICAL$ (GSH); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and @CHEMICAL$ (GSH); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of @CHEMICAL$ (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@GENE$); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (@CHEMICAL$), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@GENE$); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@CHEMICAL$); expression levels of TNF-a and IL-6; and levels of caspase-3 and @GENE$/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@CHEMICAL$); expression levels of TNF-a and IL-6; and levels of caspase-3 and pJNK/@GENE$ protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@CHEMICAL$); expression levels of @GENE$ and IL-6; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@CHEMICAL$); expression levels of TNF-a and @GENE$; and levels of caspase-3 and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Hepatic function was assessed by evaluating the following parameters: liver histology; plasma levels of alanine aminotransferase (ALT), triglyceride (TG), malondialdehyde (MDA), and reduced glutathione (@CHEMICAL$); expression levels of TNF-a and IL-6; and levels of @GENE$ and pJNK/JNK protein. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of @CHEMICAL$, hepatic TG, and MDA, and in the expression levels of TNF-a, and IL-6; on the contrary, the levels of @GENE$ increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of ALT, hepatic TG, and MDA, and in the expression levels of TNF-a, and @CHEMICAL$; on the contrary, the levels of @GENE$ increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of ALT, hepatic TG, and MDA, and in the expression levels of @CHEMICAL$, and IL-6; on the contrary, the levels of @GENE$ increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of @CHEMICAL$, hepatic TG, and @GENE$, and in the expression levels of TNF-a, and IL-6; on the contrary, the levels of reduced GSH increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of ALT, hepatic TG, and @CHEMICAL$, and in the expression levels of TNF-a, and @GENE$; on the contrary, the levels of reduced GSH increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Moreover, EDL led to a significant decrease in the serum levels of ALT, hepatic TG, and @CHEMICAL$, and in the expression levels of @GENE$, and IL-6; on the contrary, the levels of reduced GSH increased. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: A novel @CHEMICAL$ switch is a mechanism of @GENE$ resistance in gastrointestinal stromal tumors. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: A novel @CHEM-GENE$ switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Gene expression profiling (GEP) of GIST-S, GIST-R cells and two @CHEMICAL$ resistant GIST patients demonstrated that @GENE$ is downregulated implying a major role in IM resistance. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Gene expression profiling (GEP) of GIST-S, GIST-R cells and two IM resistant GIST patients demonstrated that @CHEMICAL$ is downregulated implying a major role in @GENE$ resistance. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired @CHEMICAL$ resistance by overexpressing the @GENE$ - AXL - in a 'kinase switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired @CHEMICAL$ resistance by overexpressing the oncogenic receptor tyrosine kinase - AXL - in a '@GENE$ switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired @CHEMICAL$ resistance by overexpressing the oncogenic receptor tyrosine kinase - @GENE$ - in a 'kinase switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired IM resistance by overexpressing the @CHEM-GENE$ - AXL - in a 'kinase switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired IM resistance by overexpressing the oncogenic receptor @CHEMICAL$ kinase - AXL - in a '@GENE$ switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Instead, GIST-R cells have acquired IM resistance by overexpressing the oncogenic receptor @CHEMICAL$ kinase - @GENE$ - in a 'kinase switch'. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Further, the two @CHEMICAL$ resistant GIST patients express @GENE$ and not c-Kit, seen by immunohistochemistry (IHC). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Further, the two @CHEMICAL$ resistant GIST patients express AXL and not @GENE$, seen by immunohistochemistry (IHC). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: In GIST-R, AXL is @CHEMICAL$ phosphorylated and its ligand @GENE$ is overexpressed implying autocrine activation. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: In GIST-R, @CHEMICAL$ is @GENE$ phosphorylated and its ligand growth-arrest-specific gene 6 is overexpressed implying autocrine activation. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the @CHEMICAL$ of mutant c-Kit (V654A) and AXL showed no binding to @GENE$ but efficient binding to MP470, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (@CHEMICAL$) and AXL showed no binding to @GENE$ but efficient binding to MP470, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to @CHEMICAL$ but efficient binding to MP470, a novel c-Kit/AXL @GENE$ inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant @CHEMICAL$ (V654A) and AXL showed no binding to @GENE$ but efficient binding to MP470, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and @CHEMICAL$ showed no binding to @GENE$ but efficient binding to MP470, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to @CHEMICAL$ but efficient binding to MP470, a novel @GENE$/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to @CHEMICAL$ but efficient binding to MP470, a novel c-Kit/@GENE$ kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the @CHEMICAL$ of mutant c-Kit (V654A) and AXL showed no binding to IM but efficient binding to @GENE$, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (@CHEMICAL$) and AXL showed no binding to IM but efficient binding to @GENE$, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to IM but efficient binding to @CHEMICAL$, a novel c-Kit/AXL @GENE$ inhibitor. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant @CHEMICAL$ (V654A) and AXL showed no binding to IM but efficient binding to @GENE$, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and @CHEMICAL$ showed no binding to IM but efficient binding to @GENE$, a novel c-Kit/AXL kinase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to IM but efficient binding to @CHEMICAL$, a novel @GENE$/AXL kinase inhibitor. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Molecular modeling of the kinase domain of mutant c-Kit (V654A) and AXL showed no binding to IM but efficient binding to @CHEMICAL$, a novel c-Kit/@GENE$ kinase inhibitor. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The selectins are @CHEMICAL$-dependent @GENE$ that bind certain sialylated, fucosylated, sulfated glycoprotein ligands. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The @CHEMICAL$ are @GENE$-dependent C-type lectins that bind certain sialylated, fucosylated, sulfated glycoprotein ligands. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ also recognizes endothelial proteoglycans in a @GENE$-dependent manner, via heparan sulfate (HS) glycosaminoglycan chains enriched in unsubstituted glucosamine units. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ also recognizes endothelial proteoglycans in a calcium-dependent manner, via heparan sulfate (HS) glycosaminoglycan chains enriched in unsubstituted @GENE$ units. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Despite this, HS chains bound to @CHEMICAL$ are eluted by @GENE$ (EDTA), but only at high concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Despite this, HS chains bound to @CHEMICAL$ are eluted by ethylenediamine tetraacetic acid (@GENE$), but only at high concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to @CHEMICAL$, @GENE$-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, @CHEMICAL$-dependent binding of a subfraction to @GENE$ and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, @CHEMICAL$-dependent binding of a subfraction to L-selectin and to @GENE$, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, @CHEMICAL$-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to @GENE$, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to @CHEMICAL$, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and @GENE$-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to @CHEMICAL$ and to P-selectin, and @GENE$-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to @CHEMICAL$, and @GENE$-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and @CHEMICAL$-independent binding of a larger fraction to @GENE$, the latter being disrupted by high EDTA concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to @CHEMICAL$, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to @CHEMICAL$ and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to @CHEMICAL$, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to @CHEMICAL$, the latter being disrupted by high @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Analysis of defined heparin fragment pools shows a size dependence for interaction, with @CHEMICAL$ showing easily detectable binding to @GENE$ affinity columns. | false |
Subsets and Splits