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TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of @CHEMICAL$ formation in vivo and the contribution of G(i)-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the PGI(2) receptor, @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:@CHEMICAL$ coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @GENE$ cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the PGI(2) receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of @CHEMICAL$-mediated pathways that do not involve @GENE$ cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the PGI(2) receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @CHEM-GENE$, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the PGI(2) receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @CHEMICAL$ cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed @GENE$ family members and compared the results with platelets from mice that lacked the PGI(2) receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @CHEMICAL$ cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @GENE$, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @CHEMICAL$ cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the PGI(2) receptor, @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:@CHEMICAL$ coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @GENE$ receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of @CHEMICAL$-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @GENE$ receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve @CHEMICAL$, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @GENE$ receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed @CHEMICAL$ family members and compared the results with platelets from mice that lacked the @GENE$ receptor, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @CHEM-GENE$, IP. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: To address questions about the specificity of receptor:G protein coupling, the regulation of cAMP formation in vivo and the contribution of G(i)-mediated pathways that do not involve adenylyl cyclase, we studied platelets from mice that lacked the alpha subunits of one or more of the three most abundantly expressed G(i) family members and compared the results with platelets from mice that lacked the @CHEMICAL$ receptor, @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or G(z)alpha inhibited aggregation in response to @CHEMICAL$ and epinephrine, respectively, producing defects that could not be reversed by adding an @GENE$ inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of @CHEMICAL$ or G(z)alpha inhibited aggregation in response to @GENE$ and epinephrine, respectively, producing defects that could not be reversed by adding an adenylyl cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or @CHEMICAL$ inhibited aggregation in response to @GENE$ and epinephrine, respectively, producing defects that could not be reversed by adding an adenylyl cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or G(z)alpha inhibited aggregation in response to ADP and @CHEMICAL$, respectively, producing defects that could not be reversed by adding an @GENE$ inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of @CHEMICAL$ or G(z)alpha inhibited aggregation in response to ADP and @GENE$, respectively, producing defects that could not be reversed by adding an adenylyl cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or @CHEMICAL$ inhibited aggregation in response to ADP and @GENE$, respectively, producing defects that could not be reversed by adding an adenylyl cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or G(z)alpha inhibited aggregation in response to ADP and epinephrine, respectively, producing defects that could not be reversed by adding an @CHEM-GENE$ inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of @CHEMICAL$ or G(z)alpha inhibited aggregation in response to ADP and epinephrine, respectively, producing defects that could not be reversed by adding an @GENE$ cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: As reported previously, loss of G(i2)alpha or @CHEMICAL$ inhibited aggregation in response to ADP and epinephrine, respectively, producing defects that could not be reversed by adding an @GENE$ cyclase inhibitor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of @CHEMICAL$ and epinephrine to inhibit PGI(2)-stimulated @GENE$ activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either @CHEMICAL$ or G(i2)alpha impaired the ability of @GENE$ and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or @CHEMICAL$ impaired the ability of @GENE$ and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of @CHEMICAL$ and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of @GENE$ did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and @CHEMICAL$ to inhibit PGI(2)-stimulated @GENE$ activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either @CHEMICAL$ or G(i2)alpha impaired the ability of ADP and @GENE$ to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or @CHEMICAL$ impaired the ability of ADP and @GENE$ to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and @CHEMICAL$ to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of @GENE$ did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit @CHEMICAL$-stimulated @GENE$ activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either @CHEMICAL$ or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit @GENE$-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or @CHEMICAL$ impaired the ability of ADP and epinephrine to inhibit @GENE$-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit @CHEMICAL$-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of @GENE$ did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated @CHEM-GENE$ activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either @CHEMICAL$ or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated @GENE$ cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or @CHEMICAL$ impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated @GENE$ cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated @CHEMICAL$ cyclase activity and caused a 40%-50% rise in basal cAMP levels, whereas loss of @GENE$ did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated @CHEMICAL$ activity and caused a 40%-50% rise in basal @GENE$ levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either @CHEMICAL$ or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal @GENE$ levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or @CHEMICAL$ impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal @GENE$ levels, whereas loss of G(i3)alpha did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Loss of either G(z)alpha or G(i2)alpha impaired the ability of ADP and epinephrine to inhibit PGI(2)-stimulated adenylyl cyclase activity and caused a 40%-50% rise in basal @CHEMICAL$ levels, whereas loss of @GENE$ did not. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Conversely, deletion of @CHEMICAL$ abolished responses to @GENE$ and caused cAMP levels to fall by 30%, effects that did not translate into enhanced responsiveness to agonists ex vivo. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Conversely, deletion of @CHEMICAL$ abolished responses to PGI(2) and caused @GENE$ levels to fall by 30%, effects that did not translate into enhanced responsiveness to agonists ex vivo. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through @GENE$, G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), @GENE$, and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not @GENE$; 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among @GENE$ family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and @GENE$, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine @GENE$) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) @CHEMICAL$ levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and ADP (@GENE$) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through @CHEMICAL$, G(z), and IP, but not G(i3); 2) platelet @GENE$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), @CHEMICAL$, and IP, but not G(i3); 2) platelet @GENE$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not @CHEMICAL$; 2) platelet @GENE$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet @CHEMICAL$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among @GENE$ family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet @CHEMICAL$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and @CHEMICAL$, but not G(i3); 2) platelet @GENE$ (alpha(2A)-adrenergic) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet @CHEMICAL$ @GENE$) and ADP (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet @CHEMICAL$ (alpha(2A)-adrenergic) and ADP (@GENE$) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through @CHEMICAL$, G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @GENE$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), @CHEMICAL$, and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @GENE$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not @CHEMICAL$; 2) platelet epinephrine (alpha(2A)-adrenergic) and @GENE$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @CHEMICAL$ (P2Y12) receptors display strong preferences among @GENE$ family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @CHEMICAL$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and @CHEMICAL$, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @GENE$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine @CHEMICAL$) and @GENE$ (P2Y12) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: From these results we conclude that 1) cAMP levels in circulating platelets reflect ongoing signaling through G(i2), G(z), and IP, but not G(i3); 2) platelet epinephrine (alpha(2A)-adrenergic) and @CHEMICAL$ (@GENE$) receptors display strong preferences among G(i) family members with little evidence of redundancy; and 3) these receptor preferences do not extend to G(i3). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of @CHEMICAL$ and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for @GENE$ signaling pathways that involve effectors other than adenylyl cyclase. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of @CHEMICAL$ and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and @CHEMICAL$ to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for @GENE$ signaling pathways that involve effectors other than adenylyl cyclase. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and @CHEMICAL$ to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to @CHEMICAL$-stimulated, cAMP formation highlights the need during platelet activation for @GENE$ signaling pathways that involve effectors other than adenylyl cyclase. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to @CHEMICAL$-stimulated, cAMP formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, @CHEMICAL$ formation highlights the need during platelet activation for @GENE$ signaling pathways that involve effectors other than adenylyl cyclase. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, @CHEMICAL$ formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for @CHEMICAL$ signaling pathways that involve effectors other than @GENE$ cyclase. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Finally, the failure of ADP and epinephrine to inhibit basal, as opposed to PGI(2)-stimulated, cAMP formation highlights the need during platelet activation for G(i) signaling pathways that involve effectors other than @CHEM-GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Pentosan polysulfate @CHEMICAL$ (PPS) has been shown to exert antitumor activity by antagonizing the binding of @GENE$ to cell surface receptors. | CPR:6 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Localization of the @CHEM-GENE$ RhBG and RhCG in mouse kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Localization of the @CHEMICAL$ transporter proteins @GENE$ and RhCG in mouse kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Localization of the @CHEMICAL$ transporter proteins RhBG and @GENE$ in mouse kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Recent studies have identified a family of putative @CHEM-GENE$; mRNA for two members of this family, Rh B-glycoprotein (RhBG) and Rh C-glycoprotein (RhCG), is expressed in the kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Recent studies have identified a family of putative @CHEMICAL$ transporters; mRNA for two members of this family, @GENE$ (RhBG) and Rh C-glycoprotein (RhCG), is expressed in the kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Recent studies have identified a family of putative @CHEMICAL$ transporters; mRNA for two members of this family, Rh B-glycoprotein (@GENE$) and Rh C-glycoprotein (RhCG), is expressed in the kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Recent studies have identified a family of putative @CHEMICAL$ transporters; mRNA for two members of this family, Rh B-glycoprotein (RhBG) and @GENE$ (RhCG), is expressed in the kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Recent studies have identified a family of putative @CHEMICAL$ transporters; mRNA for two members of this family, Rh B-glycoprotein (RhBG) and Rh C-glycoprotein (@GENE$), is expressed in the kidney. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of RhBG with carbonic anhydrase II, the @CHEMICAL$-sensitive transporter, and the @GENE$ AE1 and pendrin demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of RhBG with carbonic anhydrase II, the @CHEMICAL$-sensitive transporter, and the anion exchangers AE1 and pendrin demonstrated @GENE$ immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of @CHEMICAL$ with carbonic anhydrase II, the @GENE$-sensitive transporter, and the anion exchangers AE1 and pendrin demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of RhBG with @CHEMICAL$, the @GENE$-sensitive transporter, and the anion exchangers AE1 and pendrin demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of RhBG with carbonic anhydrase II, the @CHEMICAL$-sensitive transporter, and the anion exchangers @GENE$ and pendrin demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Colocalization of RhBG with carbonic anhydrase II, the @CHEMICAL$-sensitive transporter, and the anion exchangers AE1 and @GENE$ demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Immunoreactivity for a second putative @CHEM-GENE$, RhCG, was present in the apical region of cells with almost the same distribution as RhBG. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Immunoreactivity for a second putative @CHEMICAL$ transporter, @GENE$, was present in the apical region of cells with almost the same distribution as RhBG. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Immunoreactivity for a second putative @CHEMICAL$ transporter, RhCG, was present in the apical region of cells with almost the same distribution as @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings suggest that @CHEMICAL$ and RhCG may play important and cell-specific roles in @GENE$ transport and signaling in these regions of the kidney. | CPR:9 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings suggest that RhBG and @CHEMICAL$ may play important and cell-specific roles in @GENE$ transport and signaling in these regions of the kidney. | CPR:9 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Published literature on the @CHEMICAL$-cyclic guanosine monophosphate (cGMP) pathway for penile erection and on @GENE$ inhibition using sildenafil as the model for pharmacologic PDE5 inhibition are assessed. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Published literature on the @CHEMICAL$-cyclic guanosine monophosphate (cGMP) pathway for penile erection and on PDE5 inhibition using sildenafil as the model for pharmacologic @GENE$ inhibition are assessed. | false |
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