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int32
following information was supplied regarding the deposition of DNA sequences: The 16s RNA sequences of compost for Agaricus bisporus production are available at GenBank: PRJNA664798. BioSample: SAMN16233641, SAMN16233642, SAMN16233643, SAMN16233644, SAMN16233645, SAM
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3 Ophiotaenia sanbernardinensis Helicops leopardinus *MHNG-PLAT-18251 AJ388637 Zehnder et al. 1999 5.0 Ophiotaenia saphena Lithobates pipiens *MHNG-PLAT-32851 KP729402 This paper 8.3-8.7 Pangasiocestus romani (T) Pangasius larnaudii *MHNG-PLAT-75449 KP729397 This
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paper; http://www.pdb.org PDB: 5NNC Crystal structure of BRD4/BD1 with an H3 (K9ac/pS10/K14ac) peptide This paper; http://www.pdb.org PDB: 5NND Crystal structure of BRD4/BD1 with a TOP2A (K1201ac/K1204ac) peptide This paper; http://www.pdb.org PDB: 5NNE Crys
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c 3.5 Kapsulotaenia sp. 4 Varanus varius *MHNG-PLAT-32838 AJ583454 de Chambrier et al. 2004c 6.5 Macrobothriotaenia ficta (T) Xenopeltis unicolor *MHNG-PLAT-75454 KC786020 Scholz et al. 2013 4.1 Manaosia bracodemoca (T) Sorubim lima *MHNG-PLAT-34186 KP729414 This
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enome sequence from YG 130.6 https://www.ncbi.nlm. nih.gov/nuccore/ KT168329 Publicly available at NCBI GenBank (accession no: KT168329) Heintzman PD, Shapiro B 2017 Mitochondrial genome sequence from YG 417.13 https://www.ncbi.nlm. nih.gov/nuccore/ KT168330 Publ
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al author and source are credited. Data Availability Statement: All Nrf2 sequence files are available from the GeneBank database (accession number(s) KT345715, KT345716, KT345717, KT345718, KT345719, KT345720, KT345721, KT345722, KT345723, KT345724, KT345725). Da
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o R Q E D No ESEV EPI_ISL_332396_A/chicken/Jiangsu/3/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332399_A/duck/Jiangsu/1/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_293289_A/Duck/Jiangsu/12/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_293290_A/Du
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alyzed data is available in the supplemental materials for this manuscript. RNA sequencing data is available through the Gene Expression Omnibus (GEO, GSE128766), and DNA sequencing data is available through the European Genome-Phenome Archive (EGA, EGAD00001004885). Au
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VAILABILITY The assembly and annotation, as well as the raw reads, are available via BioProject PRJNA700828. The assembled genomes accession number is GCA_024582855.4. The new PacBio and Illumina raw reads can be found under the accession numbers SRX23571306 and
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D No ESEV EPI_ISL_293286_A/Chicken/Jiangsu/103/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_291131_A/Chicken/Jiangsu/1/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332358_A/chicken/Jiangsu/1/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332395_A/ch
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r-2014 JMi-231/CS1nor CS1/no KU363066 JMi-231/CS1de194 CS1/194 aa KU363067 JMi-231/CS1de214 CS1/214 aa KU363068 JMi-235 Third outbreak Ho Miyazaki Jun-14 JMi-235/CS1nor CS1/no KU363069 JMi-235/CS1de201 CS1/201 aa KU363070 JMi-235/CS1de203 CS1/203 aa KU363071 JMi-
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et al. 1999 19.4 Proteocephalus percae Perca fluviatilis *MHNG-PLAT-36744 AJ388594 Zehnder et al. 1999 13.8 Proteocephalus perplexus Amia calva *MHNG-PLAT-35366 FM956089 de Chambrier et al. 2009a 12.0 Proteocephalus pinguis Esox lucius *IPCAS C-679 KP729395 This
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sembled transcript data used in this manuscript have been submitted to European Nucleotide Archive at EMBL database with Accession Number: PRJEB25632. New Illumina data in this manuscript have been submitted to SRA database with Accession Number: PRJNA265584. Con
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mple, and the DDBJ read archive accession numbers for the genome data are PRJDB8242, SAMD00169834, and DRA008324 respectively. The genome assembly has the accession numbers: BJKT01000001BJKT01000065. The RNAseq data has accession numbers: DRA008173, DRA006301, and
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clare that they have no competing interests. Availability of data and materials All PacBio FL, non-FL, and assembled transcript data used in this manuscript have been submitted to European Nucleotide Archive at EMBL database with Accession Number: PRJEB25632. New
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is paper; http://www.pdb.org PDB: 6G0O Crystal structure of BRD4/BD1 with an E2F1 (K117ac/K120ac) peptide This paper; http://www.pdb.org PDB: 6G0P Crystal structure of BRD4/BD1 with a GATA1 (K312ac/K315ac) peptide This paper; http://www.pdb.org PDB: 6G0Q Crys
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the original author and source are credited. Data Availability Statement: All Nrf2 sequence files are available from the GeneBank database (accession number(s) KT345715, KT345716, KT345717, KT345718, KT345719, KT345720, KT345721, KT345722, KT345723, KT345724, KT3
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E D No ESEV EPI_ISL_291131_A/Chicken/Jiangsu/1/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332358_A/chicken/Jiangsu/1/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332395_A/chicken/Jiangsu/2/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332396_A/ch
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of data and in writing the manuscript. Availability of data and materials All raw sequence data generated in this study is deposited in the NCBI Sequence Read Archive (https://submit.ncbi.nlm.nih.gov/subs/sra/) under the accession number SRR8906254-SRR8906256. Add
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4 JMi-124/CS1nor CS1/no KU363059 JMi-124/CS1de194 CS1/194 aa KU363060 JMi-124/CS1de201 CS1/201 aa KU363061 JMi-124/CS1de202 CS1/202 aa KU363062 JKa-230 Primary outbreak Kac1 Kagoshima Jul-14 JKa-230/CS1nor CS1/no KU363063 JKa-230/CS1de194 CS1/194 aa KU363064 JKa-
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w England Biolabs (NEB), USA) with overnight incubation at 56 C with proteinase K. The quality of the extraction was verified by a PCR amplification of the host COI gene (Table S6). A total of 20 sequences were deposited in the GenBank Data Library: MN923050-MN92
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n of data and final manuscript. Availability of data and materials Data generated are available in GenBank: BioProject PRJNA593570; BioSample SAMN13481355 for Wolbachia endosymbiont strain of Atemnus sp. Specimen K5 (genome: WQMQ00000000); BioSample SAMN14519337 for
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No R Q E D No ESEV EPI_ISL_293289_A/Duck/Jiangsu/12/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_293290_A/Duck/Jiangsu/13/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_293291_A/Duck/Jiangsu/16/2018(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_332401_A/du
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sala University SciLifeLab SFO funds. Availability of data and materials The single-amplified genome sequence dataset generated during the current study is available in the EMBL-EBI European Nucleotide Archive repository, under the primary accession PRJEB21451. The
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111/1365-2745.13449. DATA AVAILABILITY STATEMENT Data available from the Dryad Digital Repository https://doi. org/10.5061/dryad.r7sqv9s8n (in t Zandt et al., 2020). Raw root se- quence reads are available via the NCBI SRA repository, BioProject ID PRJNA627488: htt
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lity All normalized NGS data were deposited in GEO (URL: https://www.ncbi.nlm.nih.gov/geo) under the super series accession GSE110720. Coding exome RNA-Seq data is deposited under accession GSE110716, Poly-A RNA-Seq data is deposited under accession GSE110717, RRB
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2source data 1, and the Rscript used for morphometric analysis is in the DRYAD database (Heintzman et al., 2017). MtDNA genome sequences have been deposited in Genbank under accessions KT168317-KT168336, MF134655- MF134663, and an updated version of JX312727. All
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g371/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445090 2019 April 26 A/shorebird/Liaoning/dandong386/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445091 2019 April 26 A/shorebird/Liaoning/dandong603/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445092 2019
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3 JMi-292/CS1nor CS1/no KU363091 JMi-292/CS1de197 CS1/197 aa KU363092 JMi-292/CS1de203 CS1/203 aa KU363093 JMi-292/CS1de204 CS1/204 aa KU363094 JKa-292/CS1de212 CS1/212 aa KU363095 JKa-295 Primary outbreak Kap5 Kagoshima Jan-14 JMi-295/CS1nor CS1/no KU363096 JKa-
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U363080 JMi-277/CS1de197 CS1/197 aa KU363081 JMi-277/CS1de202 CS1/202 aa KU363082 JMi-277fSnorCo11 Full S/no KU363111 KU363122 JMi-277fSnorCo12 Full S/no KU363112 KU363123 JMi-277fSnorCo13 Full S/no KU363113 KU363124 JMi-277fSde197Co26 Full S/197 aa KU363114 KU36
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48 JAi-29 Primary outbreak ToB Aichi Apr-14 JAi-29/CS1nor CS1/no KU363049 JAi-29/CS1de203 CS1/203 aa KU363050 JAi-29/CS1de204 CS1/204 aa KU363051 JAo-56 Primary outbreak Mi Aomori May-14 JAo-56/CS1de194 CS1/194 aa KU363052 JAo-56/CS1de212 CS1/212 aa KU363053 JAo-
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-295fSde197Co5 Full S/197 aa KU363118 KU363129 JKa-295fSde197Co8 Full S/ 197 aa KU363120 KU363131 JKa-295fSde215Co6 Full S/ 215 aa KU363119 KU363130 JAi-312 Second outbreak Tom Aichi Jan-15 JAi-312/CS1nor CS1/ no KU363104 JAi-312/CS1de194 CS1/194 aa KU363105 JAi-
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a et al. 2012). Paired-end sequencing with reads of 75 and 250 nucleotides in length were performed with at least 10X coverage. All raw and processed data are available through the European Nucleotide Archive under acces- sion numbers PRJEB22479 and PRJEB25675 for
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Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License 5622 | WAN et al. submitted to the National Center for Biotechnology Information (NCBI) database (accession numbers: MN107084MN107151, MN335287MN335
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g386/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445091 2019 April 26 A/shorebird/Liaoning/dandong603/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445092 2019 April 26 A/shorebird/Liaoning/dandong786/2019(H7N4) 1 Shorebird (species unknown) EPI_ISL_445093 2019
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unding bodies had no role in the design of the study or collection, analysis, or interpretation of data. Availability of data and materials New sequencing data, genome assemblies, and annotations have been deposited under NCBI BioProject accession PRJNA396570 (htt
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web.lunenfeld.ca/ Project 40 (BET rewiring) Crystal structure of BRD4/BD1 with an H3 (K9ac/K14ac) peptide This paper; http://www.pdb.org PDB: 5NNC Crystal structure of BRD4/BD1 with an H3 (K9ac/pS10/K14ac) peptide This paper; http://www.pdb.org PDB: 5NND Crys
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19 February 2022 Accepted 25 May 2022 Edited by K. Djinovic-Carugo, University of Vienna, Austria Keywords: L-asparaginases; Ntn-hydrolases; random mutagenesis; leukemia. PDB references: EcAIII, wild type, 7qy6; RDM1-3, 7qtc; RDM1-8, 7qq8; RDM1-12, 7qsf; RDM
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use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All Nrf2 sequence files are available from the GeneBank database (accession number(s) KT345715, KT345716, KT345717, KT345718, KT3
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97 CS1/197 aa KU363098 JKa-295/CS1de201 CS1/201 aa KU363099 JKa-295/CS1de204 CS1/204 aa KU363100 JKa-295/CS1de205 CS1/205 aa KU363101 JKa-295/CS1de211 CS1/211 aa KU363102 JKa-295/CS1de216 CS1/216 aa KU363103 JKa-295fSde194Co25 Full S/194 aa KU363121 KU363132 JKa-
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i-278 Second outbreak Is Miyazaki Feb-14 JMi-278/CS1nor CS1/no KU363083 JMi-278/CS1del194 CS1/194 aa KU363084 JMi-278/CS1del203 CS1/203 aa KU363085 JMi-278/CS1de214 CS1/214 aa KU363086 JMi-283 Second outbreak Oi Miyazaki Jun-14 JMi-283/CS1nor CS1/no KU363087 JMi-
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ug Bank PIK3R1, PIK3R2, PIK3R3, PIK3R4, PIK3R5, PIK3R6, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3 ROS NOX1, NOX3, NOX4 Fostamatinib Approved Drug Bank NOX2 Dextromethorphan Approved Drug Bank Tetrahydroisoquino lines (CHEMBL3733336 , CHEMBL3347550, CH
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KU363099 JKa-295/CS1de204 CS1/204 aa KU363100 JKa-295/CS1de205 CS1/205 aa KU363101 JKa-295/CS1de211 CS1/211 aa KU363102 JKa-295/CS1de216 CS1/216 aa KU363103 JKa-295fSde194Co25 Full S/194 aa KU363121 KU363132 JKa-295fSde197Co4 Full S/197 aa KU363117 KU363128 JKa-
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Y.L. and R.G. performed the X-ray crystallographic measurements. H.H. conducted theoretical studies. R.K. conceived and supervised the study, and drafted the manuscript. All authors contributed to discussions. Additional information Accession codes. CCDC 14429101442
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genome sequence from YG 417.13 https://www.ncbi.nlm. nih.gov/nuccore/ KT168330 Publicly available at NCBI GenBank (accession no: KT168330) Heintzman PD, Shapiro B 2017 Mitochondrial genome sequence from YG 76.2 https://www.ncbi.nlm. nih.gov/nuccore/ KT168331 Publ
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/no KU363079 JMi-277/CS1de194 CS1/194 aa KU363080 JMi-277/CS1de197 CS1/197 aa KU363081 JMi-277/CS1de202 CS1/202 aa KU363082 JMi-277fSnorCo11 Full S/no KU363111 KU363122 JMi-277fSnorCo12 Full S/no KU363112 KU363123 JMi-277fSnorCo13 Full S/no KU363113 KU363124 JMi-
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s further supported by funds from the EPFL, AgingX (SystemsX.ch), and the SNSF (CRSI33_127485). Availability of data and materials The RNA-seq and ChIP-seq datasets supporting the conclusions of this article are available in the NCBI GEO repository, GSE118622 [57]
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s://massive.ucsd.edu/ ProteoSAFe/static/massive.jsp MSV000081006 MS data of BRD3 mutant BioID https://massive.ucsd.edu/ ProteoSAFe/static/massive.jsp MSV000081001 MS data of BRD9 fragment AP-MS https://massive.ucsd.edu/ ProteoSAFe/static/massive.jsp MSV000080981 MS d
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Inc., Internal Research Funding who approved the design of the study and collection, analysis, interpretation of data and final manuscript. Availability of data and materials Data generated are available in GenBank: BioProject PRJNA593570; BioSample SAMN13481355 for
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e, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All Nrf2 sequence files are available from the GeneBank database (accession number(s) KT345715, KT3
1
provided the original author and source are credited. Data Availability Statement: All Nrf2 sequence files are available from the GeneBank database (accession number(s) KT345715, KT345716, KT345717, KT345718, KT345719, KT345720, KT345721, KT345722, KT345723, KT3
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Biolabs (NEB), USA) with overnight incubation at 56 C with proteinase K. The quality of the extraction was verified by a PCR amplification of the host COI gene (Table S6). A total of 20 sequences were deposited in the GenBank Data Library: MN923050-MN923069 (Tab
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, NIH P20GM121342 (KEP), NIH R15DE029945 (KEP), NSF IOS-1456765 (RBR) and an Arnold and Mabel Beckman Institute Young Investigator Award (RBR). DATA AVAILABILITY STATEMENT Raw sequence data are available at https://www.ncbi.nlm.nih. gov/bioproject/PRJNA955776. Add
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4/CS1de202 CS1/202 aa KU363062 JKa-230 Primary outbreak Kac1 Kagoshima Jul-14 JKa-230/CS1nor CS1/no KU363063 JKa-230/CS1de194 CS1/194 aa KU363064 JKa-230/CS1de214 CS1/214 aa KU363065 JMi-231 Second outbreak Ho Miyazaki Mar-2014 JMi-231/CS1nor CS1/no KU363066 JMi-
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s paper; http://www.pdb.org PDB: 6G0Q Crystal structure of BRD4/BD1 with a POL2RA (K775ac/K778ac) peptide This paper; http://www.pdb.org PDB: 6G0R Crystal structure of BRD4/BD1 with a SIRT7 (K272ac/K275ac) peptide This paper; http://www.pdb.org PDB: 6G0S (Con
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, rev 2fcb244) and Gene Set Enrichment Analysis (GSEA, v4.0.3) [88, 89]. One sample was excluded due to anom- alously different transcript counts (89-5, a PBS.3WK replicate). Raw transcriptomic data is accessible via the NIH Gene Expression Omnibus (GSE144193) and
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A, New Haven, CT). For the generation of these cDNA libraries, 900 ng of high quality (RNA integrity number > 7.0) total RNA samples was used. The Sequence Read Archive number at NCBI of infected cardia is SRP093558 and that of infected probosces is PRJNA354110 [30]
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nd does not imply endorsement by the U.S. Government. CONFLICT OF INTEREST The authors have declared no conflict of interest for this article. DATA AVAILABILITY STATEMENT 16S rRNA sequences have been deposited in the Sequence Read Archive at NCBI (PRJNA794822). Me
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that of the present study, and details of the study protocol were previously published [32]. All microarray data have been deposited in the National Center for Biotechnology Gene Expression Omnibus database (accession numbers [GEO:GSE26440] and [GEO:GSE26378]). R
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U363044 JAi-23/CS1de202 CS1/202 aa KU363045 JAi-23/CS1de204 CS1/204 aa KU363046 JAi-23/CS1de209 CS1/209 aa KU363047 JAi-23/CS1de214 CS1/214 aa KU363048 JAi-29 Primary outbreak ToB Aichi Apr-14 JAi-29/CS1nor CS1/no KU363049 JAi-29/CS1de203 CS1/203 aa KU363050 JAi-
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al. 2011, Oyola et al. 2012). Paired-end sequencing with reads of 75 and 250 nucleotides in length were performed with at least 10X coverage. All raw and processed data are available through the European Nucleotide Archive under acces- sion numbers PRJEB22479 and
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nd then stored at 80 C prior to RNA extraction. RNA extraction and transcription analysis were performed as previously described [22]. Resulting microarray data were uploaded to the Gene Expression Omnibus (GEO) database under Accession Number GSE72765. Hie
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igh metabolic plasticity of the MAST species analyzed here, which might facilitate their existence in the oceans as very abundant bacterial grazers. Data availability Sequencing reads have been deposited at the GenBank Database under Project numbers PRJEB6603 for
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testudo (T) Apalone spinifera *MHNG-PLAT-35320 FM956082 de Chambrier et al. 2009a 6.2 Thaumasioscolex didelphidis (T) Didelphis marsupialis *MHNG-PLAT-28993 AJ275065 de Chambrier et al. 2004c 8.4 Travassiella jandia (T) Zungaro jahu MHNG-PLAT-31175 KP729400 This
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n type of PEDV. Table 3. (Continued) Sample Outbreak Farm Prefecture Collected time PEDV strains Sequence/ deletion S geneacce No ORF3 geneacce No JMi-278 Second outbreak Is Miyazaki Feb-14 JMi-278/CS1nor CS1/no KU363083 JMi-278/CS1del194 CS1/194 aa KU363084 JMi-
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un-14 JMi-238/CS1nor CS1/no KU363072 JMi-238/CS1de194 CS1/194 aa KU363073 JMi-238/CS1de202 CS1/202 aa KU363074 JMi-238/CS1de214 CS1/214 aa KU363075 JMi-239 Second outbreak Sa Miyazaki Jul-14 JMi-239/CS1nor CS1/no KU363076 JMi-239/CS1de202 CS1/202 aa KU363077 JMi-
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input s.e.m. ChIP libraries were prepared using ChIP DNA ac- cording to the BGISEQ-500ChIP-Seq library preparation protocol. In-depth whole-genome DNA sequencing was performed by BGI (Shenzhen, China). ChIP-seq data were deposited in the NCBI SRA: SRP149488 (htt
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entary material Supplementary material is available online at Evolution. Data availability The sequence reads have been submitted to the Sequence Read Archive (SRA) of the National Center for Biotechnology Information (NCBI) under accession number PRJNA1009132. Th
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nome sequence from YG 133.16 https://www.ncbi.nlm. nih.gov/nuccore/ KT168318 Publicly available at NCBI GenBank (accession no: KT168318) Heintzman PD, Shapiro B 2017 Mitochondrial genome sequence from YG 29.169 https://www.ncbi.nlm. nih.gov/nuccore/ KT168319 Publ
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104 JAi-312/CS1de194 CS1/194 aa KU363105 JAi-312/CS1de197 CS1/197 aa KU363106 JAi-312/CS1de214 CS1/214 aa KU363107 JAi-318 Third outbreak At Aichi Jun-15 JAi-318/CS1nor CS1/no KU363108 JAi-318/CS1de194 CS1/194 aa KU363109 JAi-318/CS1de197 CS1/204 aa KU363110 : PE
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phalus gobiorum Neogobius fluviatilis IPCAS C-299 KP729393 This paper 19.7 Proteocephalus hemioliopteri Phractocephalus hemioliopterus *MHNG-PLAT-21889 AJ388622 Zehnder et al. 1999 11.8 Proteocephalus kuyukuyu Pterodoras granulosus *MHNG-PLAT-66572 KP729388 This
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999 3.3 Ophiotaenia cf. perspicua Nerodia rhombifer *MHNG-PLAT-35370 KP729415 This paper 2.3 Ophiotaenia sanbernardinensis Helicops leopardinus *MHNG-PLAT-18251 AJ388637 Zehnder et al. 1999 5.0 Ophiotaenia saphena Lithobates pipiens *MHNG-PLAT-32851 KP729402 This
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.5 Australotaenia bunthangi Enhydris enhydris *MHNG-PLAT-75447 KP729409 This paper 5.0 Barsonella lafoni (T) Clarias gariepinus *MHNG-PLAT-49399 FM955143 de Chambrier et al. 2009b 11.5 Brayela karuatayi (T) Platynematichthys notatus *MHNG-PLAT-63128 KP729406 This
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pplied regarding the deposition of DNA sequences: The 16s RNA sequences of compost for Agaricus bisporus production are available at GenBank: PRJNA664798. BioSample: SAMN16233641, SAMN16233642, SAMN16233643, SAMN16233644, SAMN16233645, SAMN16233646, SAMN16233647, SAM
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nd sequencing with reads of 75 and 250 nucleotides in length were performed with at least 10X coverage. All raw and processed data are available through the European Nucleotide Archive under acces- sion numbers PRJEB22479 and PRJEB25675 for the RJF, PRJEB24169 for
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S1nor CS1/no KU363079 JMi-277/CS1de194 CS1/194 aa KU363080 JMi-277/CS1de197 CS1/197 aa KU363081 JMi-277/CS1de202 CS1/202 aa KU363082 JMi-277fSnorCo11 Full S/no KU363111 KU363122 JMi-277fSnorCo12 Full S/no KU363112 KU363123 JMi-277fSnorCo13 Full S/no KU363113 KU36
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y file 1. MTIII and other element measurement data are in Figure 2source data 1, and the Rscript used for morphometric analysis is in the DRYAD database (Heintzman et al., 2017). MtDNA genome sequences have been deposited in Genbank under accessions KT168317-KT16
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JKa-295/CS1de194 CS1/194 aa KU363097 JKa-295/CS1de197 CS1/197 aa KU363098 JKa-295/CS1de201 CS1/201 aa KU363099 JKa-295/CS1de204 CS1/204 aa KU363100 JKa-295/CS1de205 CS1/205 aa KU363101 JKa-295/CS1de211 CS1/211 aa KU363102 JKa-295/CS1de216 CS1/216 aa KU363103 JKa-
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dosymbiont strain of Atemnus sp. Specimen K5 (genome: WQMQ00000000); BioSample SAMN14519337 for Wolbachia endosymbiont strain of Atemnus sp. Specimen K3 (genome: JAAXCS000000000). The raw data are available in GenBank as Sequence Read Archive (SRA): SRX7550679 to S
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into PHASE format. Homozygotes were treated as haploid and heterozygotes were treated as diploid samples for haplotype identification. Data availability All sequences were submitted to the NCBI SRA associated with BioProject numbers PRJNA473780 and PRJNA488050. Sup
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BioSample: SAMN16233641, SAMN16233642, SAMN16233643, SAMN16233644, SAMN16233645, SAMN16233646, SAMN16233647, SAMN16233648, SAMN16233649, SAMN16233650, SAMN16233651, SAMN16233652, SAMN16233653, SAMN16233654, SAMN16233655, SAMN16233656, SAMN16233657, SAMN16233658, SAM
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ted time PEDV strains Sequence/ deletion S geneacce No ORF3 geneacce No JMi-278 Second outbreak Is Miyazaki Feb-14 JMi-278/CS1nor CS1/no KU363083 JMi-278/CS1del194 CS1/194 aa KU363084 JMi-278/CS1del203 CS1/203 aa KU363085 JMi-278/CS1de214 CS1/214 aa KU363086 JMi-
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pporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.2c06519. Synthesis, spectroscopic characterization, crystallo- graphic details, magnetic property measurements, and computational details (PDF) Accession Codes CCDC 2169273 and
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Mi-278/CS1del203 CS1/203 aa KU363085 JMi-278/CS1de214 CS1/214 aa KU363086 JMi-283 Second outbreak Oi Miyazaki Jun-14 JMi-283/CS1nor CS1/no KU363087 JMi-283/CS1de194 CS1/194 aa KU363088 JMi-283/CS1de203 CS1/203 aa KU363089 JMi-283/CS1de214 CS1/214 aa KU363090 JKa-
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an-14 JMi-295/CS1nor CS1/no KU363096 JKa-295/CS1de194 CS1/194 aa KU363097 JKa-295/CS1de197 CS1/197 aa KU363098 JKa-295/CS1de201 CS1/201 aa KU363099 JKa-295/CS1de204 CS1/204 aa KU363100 JKa-295/CS1de205 CS1/205 aa KU363101 JKa-295/CS1de211 CS1/211 aa KU363102 JKa-
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nome sequence from YG 378.5 https://www.ncbi.nlm. nih.gov/nuccore/ KT168323 Publicly available at NCBI GenBank (accession no: KT168323) Heintzman PD, Shapiro B 2017 Mitochondrial genome sequence from YG 404.478 https://www.ncbi.nlm. nih.gov/nuccore/ KT168324 Publ
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JMi-231/CS1de214 CS1/214 aa KU363068 JMi-235 Third outbreak Ho Miyazaki Jun-14 JMi-235/CS1nor CS1/no KU363069 JMi-235/CS1de201 CS1/201 aa KU363070 JMi-235/CS1de203 CS1/203 aa KU363071 JMi-238 Second outbreak Te Miyazaki Jun-14 JMi-238/CS1nor CS1/no KU363072 JMi-
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JMi-239 Second outbreak Sa Miyazaki Jul-14 JMi-239/CS1nor CS1/no KU363076 JMi-239/CS1de202 CS1/202 aa KU363077 JMi-239/CS1de203 CS1/203 aa KU363078 JMi-277 Second outbreak No Miyazaki May-14 JMi-277/CS1nor CS1/no KU363079 JMi-277/CS1de194 CS1/194 aa KU363080 JMi-
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enome sequence from YG 130.55 https://www.ncbi.nlm. nih.gov/nuccore/ KT168326 Publicly available at NCBI GenBank (accession no: KT168326) Heintzman PD, Shapiro B 2017 Mitochondrial genome sequence from YG 198.1 https://www.ncbi.nlm. nih.gov/nuccore/ KT168327 Publ
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CS1de203 CS1/203 aa KU363078 JMi-277 Second outbreak No Miyazaki May-14 JMi-277/CS1nor CS1/no KU363079 JMi-277/CS1de194 CS1/194 aa KU363080 JMi-277/CS1de197 CS1/197 aa KU363081 JMi-277/CS1de202 CS1/202 aa KU363082 JMi-277fSnorCo11 Full S/no KU363111 KU363122 JMi-
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Pro 3.0.6 Software (Axon Instruments (now Molecular Devices), Union City, California, USA) to produce two TIFF images at 532 nm and 635 nm. The microarray data have been submitted to the Gene Expression Omnibus database, with acces- sion number [GEO:GSE24237]. St
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(URL: https://www.ncbi.nlm.nih.gov/geo) under the super series accession GSE110720. Coding exome RNA-Seq data is deposited under accession GSE110716, Poly-A RNA-Seq data is deposited under accession GSE110717, RRBS data is deposited under accession GSE110718 and
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5 JMi-69/CS1de194 CS1/194 aa KU363056 JMi-69/CS1de204 CS1/204 aa KU363057 JMi-69/CS1de214 CS1/214 aa KU363058 JMi-124 Primary outbreak Ok Miyazaki Mar-14 JMi-124/CS1nor CS1/no KU363059 JMi-124/CS1de194 CS1/194 aa KU363060 JMi-124/CS1de201 CS1/201 aa KU363061 JMi-
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G No R Q E D No ESEV A/shorebird/Liaoning/dandong386/2019(H7N4) PELPKGR G Q G No R Q E D No ESEV A/shorebird/Liaoning/dandong603/2019(H7N4) PELPKGR G Q G No R Q E D No ESEV A/shorebird/Liaoning/dandong786/2019(H7N4) PELPKGR G Q G No R Q E D No ESEV EPI_ISL_376123_A/Ji
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assembly and annotation, as well as the raw reads, are available via BioProject PRJNA700828. The assembled genomes accession number is GCA_024582855.4. The new PacBio and Illumina raw reads can be found under the accession numbers SRX23571306 and SRX23584000, res
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hyper and pheatmap were used to conduct PCA analysis, KEGG pathway enrichment and construction of heat maps, respectively. The RNA- Seq data of the present study had been deposited at the BIG genome sequence archive (GSA) under Bioproject identifier PRJCA001964 with
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e, dnaA, coxA, fbpA, gatB and ftsZ) as described in Lefoulon et al. [14] (Table S6). For some specimens, nested PCR amplification was necessary to obtain suffi- cient PCR product. A total of 14 sequences were depos- ited in the GenBank Data Library: MN931247 to M
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l. 1999 9.7-10.3 Regoella brevis (T) Pseudoplatystoma reticulatum *MHNG-PLAT-79184 KP729389 This paper 11.5 Ritacestus ritaii (T) Rita rita *MHNG-PLAT-63242 JX477447 Ash et al. 2012 17.7 Rostellotaenia nilotica (T) Varanus niloticus *MHNG-PLAT-34195 KP729398 This
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dagascariensis) EPI_ISL_445051 2019 April 26 A/eastern curlew/Liaoning/dandong1144/2019(H7N4) 3 Eastern curlew (Numenius madagascariensis) EPI_ISL_445001 2019 April 26 A/little curlew/Liaoning/dandong142/2019(H7N4) 4 Little curlew (Numenius minutus) EPI_ISL_445089 Infl
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91 911 Received 19 February 2022 Accepted 25 May 2022 Edited by K. Djinovic-Carugo, University of Vienna, Austria Keywords: L-asparaginases; Ntn-hydrolases; random mutagenesis; leukemia. PDB references: EcAIII, wild type, 7qy6; RDM1-3, 7qtc; RDM1-8, 7qq8; RDM
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