Hi, I'm very confused about the IGH gene. So on NCBI it looks to be a single IGH@ gene or locus. however 

the region seems to cover many other IGH genes IGHD1, G1, exc... 
this is how it looks like, [browser][1] 

Why I'm interested is because of gene fusions where the 3' gene is written as IGH.  However, this is ambiguous because this region seems to cover many variants. My questions are the following. 
1. is IGH a single gene or locus containing many small variants.  Or if this a gene that gets post prossessed post joining different segments?
1b. do these IGH "variant" contain exons/intron boundaries. 
2. On the CCDS website I cannot seem to be be able to locate any IGH genes at all. What I want is to have the coordinates and sequences for each variant. 
3. Is there a place I can get the the sequences for each segment and coordinate, best if I can find it on CCDS. 

thanks in advance. 


  [1]: https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&lastVirtModeType=default&lastVirtModeExtraState=&virtModeType=default&virtMode=0&nonVirtPosition=&position=chr14%3A105586437%2D106879844&hgsid=1475821023_Ps5LU7lpkag5rANMUtJpmWA2WtQW
1.The IGH locus contains many V, D, and J gene segments, as well as constant region genes.  The exact number of V, D, and J genes will depend on the species.  For example, cows have 12 V, 16 D, and 4 J regions at the IGH locus.  Canonical antibodies are composed of two heavy chains (HC) and two light chains (LC).  B cells make antibodies.  During B cell development, a V, a D, and a J gene combine to form the variable region of the HC.  The variable region is joined to a constant region to make a full length HC.  See the Wikipedia link below for a description of V(D)J recombination:

[V(D)J recombination][1]

1b.  Yes, there are introns and exons in IGH.

2 and 3. You can find sequences and coordinates of IGH genes for human, mouse, pig, teleostei, chondrichthyes, camel, llama, alpaca, caiman, sheep, frog, rat, nonhuman primates, rabbit, platypus, bovine, chicken, dog, Atlantic salmon, rainbow trout, horse, and ring-tailed lemur in the IMGT gene tables:

[IMGT Repertoires][2]

Note: antibodies also contain signal sequences (called L-part on IMGT) that direct the antibody to be displayed on the plasma membrane.


  [1]: https://en.wikipedia.org/wiki/V(D)J_recombination
  [2]: https://www.imgt.org/IMGTrepertoire/LocusGenes/#F