Hey guys,

I am going to aligning reads from GSE35641 (http://www.ncbi.nlm.nih.gov/Traces/sra/?view=search_seq_name&exp=SRX119208&run=&m=search&s=seq), on ecoli reference genome (NC_000913). There are 6 sra files in GEO which the least size is more than 2G. Do you know any way to download the files faster? I need many hours to download a file of them in fasta format

Thank you biostars
Look at using [aspera from the command line][1] or, if you are using R, as described in sections 3.5 and 3.6 of [the SRAdb vignette][2].

 [1]: http://www.ncbi.nlm.nih.gov/books/NBK158899/
 [2]: http://www.bioconductor.org/packages/release/bioc/vignettes/SRAdb/inst/doc/SRAdb.pdf