Hi,
I want to perform differential expression analysis of a GSE Series **GSE138214** (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138214) using limma in R. I am unable to extract data from this series as this series has around 14 different platforms.

Using GEOquery and limma package, I am able to differentially analyse genes in Series **GSE138260** (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138260), since it has only one platform.

But the GSE138214 series has 14 platforms and I am not sure how to work around it.

Thanks
It looks like you are interested in differential gene expression. Note that there are only two samples, so statistics won't work for you here. Also, these are tiling arrays, not traditional gene expression arrays. Finally, the GEO submission did not include values, so `getGEO` will have to be augmented with custom code and accessing supplemental files. In short, it will be a lot of work for potentially little reward. 