<p>I have a very basic question. I have created a local (mysql) database in my system. I would like to know what would be the best option for a front end. I had used html before and want to try out something new. I might also add some perl code in between for some computational work. Kindly help me in this regard..</p>

Assuming that by "front end" you mean web interface, there are many possible solutions.

Since you mention Perl, you might want to look at a web framework such as:

 - <a href="http://cgiapp.erlbaum.net/">CGI::Application</a>
 - <a href="http://www.catalystframework.org/">Catalyst</a>

At the very least, you should be familiar with <a href="http://search.cpan.org/~capttofu/DBD-mysql-4.014/lib/DBD/mysql.pm">DBD::mysql</a>; you can "roll your own" Perl CGI around that, perhaps using <a href="http://search.cpan.org/dist/CGI.pm/lib/CGI.pm">CGI.pm</a>.