What's ab initio method in bioinformatics? Can you give me a general overview of this? You can indicate me a source where can find this informations.
As https://www.biostars.org/u/24526/ said, there are several different "*ab initio*" in bioinformatics, e.g.:

 - *ab initio* protein folding
 - *ab initio* gene prediction
 - *ab initio* genome assembly

And so on. In general, *ab initio* in bioinformatics means "without direct evidence". For example, *ab initio* genome assembly is assembling a genome from sequencing reads alone, without any other information like a closely related genome or a genetic map.