Hi
I'm working on exome dataset I generated variant calls from different combination of aligners vs variant callers. Can i benchmark my exome dataset with Genome-in-bottle (HG001, HG002,HG003, HG004 & HG005)
to find the Truth positives (TP) and False positives (FP). Is this the way ?
Benchmarking mean you can take any query dataset and do comparative analysis with confidence calls (HG001 ....HG005).
Can any one explain, I'm very confused with benchmarking ?

Thanks for your comments.

You can now benchmark your own variant calls against HG002/HG003/HG004 on [Truwl][1] using 4 popular regions (more coming) and see how your results stack up against the top PrecisionFDA Truth Challenge competitors.

https://medium.com/truwl/accessible-and-uniform-benchmarking-22f598616ef5


  [1]: https://truwl.com/workflows/library/Variant%20Benchmarking/0.2