Hi all

Recently, I deal with some human gene data and I want to know if the gene I handled is conserved gene.

Is any database provide human genes' conservation scores?

I need all human genes' conservation scores. 

I know UCSC Genome Table Browser provide sequence conservation scores like phastCons and phyloP. But I can't find gene's conservation score.

Does anyone can teach me how to get it?

The format which I want is 

```
Gene ID 1 (Ensembl ID or Refseq ID )  | conservation score
Gene ID  2 (Ensembl ID or Refseq ID )  | conservation score
```

Thanks
<p>I think it depends on exactly what information you want. Is it conservation between human and a particular species? The UCSC conservation scores give you a measure of conservation based on an alignment between human and 45 other species (here is the <a href='http://hgdownload.cse.ucsc.edu/goldenPath/hg19/phastCons46way/'>information along with download links</a>), which is good for a general impression of conservation levels, but less good for a specific question like "how different is this gene in the marmoset?" (for which you'd want a specific pairwise alignment). They also have a subset of scores for primates, and for placental mammals. So, one way to do it would be to download the data, then process it to extract the answer you're looking for (e.g. get the average phastCons score using the exons, or just coding sequence, of each human gene, then use that average as your gene conservation score). What you mean by "gene" would also depend on the question you were trying to answer - for example, introns may or may not be of interest to you. </p>
