Is it possible to skip the estimateSizeFactor step in Deseq2 and define your own size factors? If I just replace the size factor vector with my own values, will the down-stream DE steps use these values? I am pretty new with R so it would be very helpful if I can see some example code on how to do this. 
Hi,

Short answer : yes and yes !

As for the example code, see my answer [here][1].


  [1]: https://www.biostars.org/p/159472/#159511

or more to the point :

    sizeFactors(cds) = c(my_Values)