Hello,

I'm wondering how to get the start and the end positions of all promoters in all human chromosomes?

Thanks
At Ensembl we've annotated promoters as part of our regulatory build ([shiny new paper on it][1]). These are based on segmentation data from ENCODE and RoadMap Epigenomics, finding consensus regions of promoter activity between cell types. This will be further refined as we add more cell types to the analysis (e.g. more from ENCODE and RoadMap and add in Blueprint).

You can access these annotations through the Ensembl Browser ([here][2] is one at the 5' end of a gene, where we expect it to be), BioMart (e.g. [this query][3] will get you all the predicted promoters on chromosome 21), the Ensembl APIs and [the Ensembl FTP site][4].

 [1]: http://genomebiology.com/2015/16/1/56/abstract
 [2]: http://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000164190;q=;r=5:36872531-36882821
 [3]: http://www.ensembl.org/biomart/martview/eae58d86e73c969c2ae027c0b7329c8a?VIRTUALSCHEMANAME=default&ATTRIBUTES=hsapiens_regulatory_feature.default.regulatory_feature.chromosome_name|hsapiens_regulatory_feature.default.regulatory_feature.chromosome_start|hsapiens_regulatory_feature.default.regulatory_feature.chromosome_end|hsapiens_regulatory_feature.default.regulatory_feature.feature_type_name&FILTERS=hsapiens_regulatory_feature.default.filters.regulatory_feature_type_name.&quot;Promoter&quot;|hsapiens_regulatory_feature.default.filters.chromosome_name.&quot;21&quot;&VISIBLEPANEL=resultspanel
 [4]: ftp://ftp.ensembl.org/pub/current_regulation/homo_sapiens/