Hi guys, 
is it possible that there exist tumor patients without mutations in driver cancer genes? 


Kind regards, 

B
Obviously, certain viruses can initiate oncogenesis by introducing their own drivers into the host cell (rather than mutating host-cell drivers).
But also, it's very likely that solid tumours may lack mutations in known driver genes, since these gene lists are continually being redefined as more studies are performed. 

... and look into medulloblastoma

... and not all mutations in driver genes are driver mutations
