I'm working on a dataset in an insect species. I was using [KAAS][1] to annotate the genes. In the parameter for "GENES data set", I only selected some species from insects. 

But in the results, the Pathway Mapping gave pathways definitely human specific, E.g. "Coronavirus disease - COVID-19". In this pathway, there is one KO [K02580][2]. This KO belongs to many pathways. One of them is "Coronavirus disease - COVID-19". My question is:

Is there a way that I can exclude some of the pathways that we know definitely not related to insects? Any suggestions? Thanks. 


  [1]: https://www.genome.jp/kaas-bin/kaas_main
  [2]: https://www.genome.jp/dbget-bin/www_bget?ko:K02580
Yes I do. This is what I did:
1. In the webpage of KAAS, I'll get a list of species I would like to limit the pathways to. eg. dme, dya. 
2. Download the pathways for the species you selected using the link below:

[http://rest.kegg.jp/link/pathway/dme][1]

[http://rest.kegg.jp/link/pathway/dya][2]

In the second column, you will see the IDs. I put an example down below here: 
dme:Dmel_CG10160	path:dme00010

The idea is that dme00010 and ko00010 are referencing to the same pathway:

[https://www.genome.jp/entry/dme00010][3]

[https://www.genome.jp/entry/ko00010][4]

So you can only include that pathways that are in the selected species based on the IDs without letters prefixed. 

Hope this helps. 


  [1]: http://rest.kegg.jp/link/pathway/dme
  [2]: http://rest.kegg.jp/link/pathway/dya
  [3]: https://www.genome.jp/entry/dme00010
  [4]: https://www.genome.jp/entry/ko00010