<p>I&#39;ve got the DNA mutation information which can be in a file format like VCF or MAF. Actually what I want to look at is how the mutation influence the corresponding amino acid changes.</p>

<p>Are there any tools can generate the mutated protein sequences corresponding to the mutated DNA in batch?</p>

<p>Many thanks.</p>

<p>Great question (for that reason I upvoted it). You might try the R package &quot;CustomProDB&quot; which takes a VCF as input and outputs a protein fasta incorporating SNVs and Indels.</p>

<p>http://www.bioconductor.org/packages/release/bioc/html/customProDB.html</p>
