<p>I have some Genomic coordinates based on hg19 which is equal to GRCH37 and I would like to analyze these coordinates using actual genome sequences. In Ensembl, There are several releases of Grch like GRCH37.70 and GRCH37.75 etc. I am wondering what is the actual difference between all these releases of GRCH37 ?! Are the coordinates the same for all these releases?!</p>

<p><a href="http://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/human/">This </a>is the website of the Genome Reference Consortium, might be informative for you to poke around there</p>

<p>hg19 is typically thought of as a subset of GRCh37 with the GRCh37p# representing different minor / patch releases (changes do not affect coordinates)</p>

<p>Ensembl uses a different versioning system, you can find their list of changes here: <a href="http://www.ensembl.org/Help/ArchiveList">http://www.ensembl.org/Help/ArchiveList</a> though it seems like the latest release is mostly schema changes with some changes to annotations.</p>
