Hello everyone, 
I'm using salmon for the alignment of SE sequencing fastq file. 
at some point I have this output:

    [warning] Fragment GC bias correction is currently *experimental* in single-end libraries.  Please use this option with caution.


It's not clear to me what does it mean to use this parameter ( --gcBias ) with caution, what happens if I use it? can I or not? 

Thank you, in particular to who made this amazing tool



There is a lengthy discussion about it at Salmon issue  83:

["--gcBias" option for single-end reads?][1]

  [1]: https://github.com/COMBINE-lab/salmon/issues/83

The crux of the problem is (and I quote **rob-p**, Salmon developer) "Given a single-end read, one does not know the length of the fragment from which it originates". If I am not mistaken, the method implemented just uses the mean fragment length to apply the GC-bias correction, and wasn't subjected to extensive validation, thus it is considered experimental.