id stringlengths 1 3 | document_id stringlengths 12 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
0 | PMID-1419903 | [
{
"id": "PMID-1419903__text",
"type": "abstract",
"text": [
"Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. \nThe present work has examined the effects of okadaic acid, an inhibitor of type 1 and 2A protein phosphatases, on the regulation of c-jun exp... | [
{
"id": "PMID-1419903_T1",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "PMID-1419903_T2",
"type": "Protein",
"text": [
"type 1"
],
"offsets": [
[
170,
... | [] | [] | [] |
1 | PMID-10364157 | [
{
"id": "PMID-10364157__text",
"type": "abstract",
"text": [
"Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. \nMalignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not u... | [
{
"id": "PMID-10364157_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
58,
62
]
],
"normalized": []
},
{
"id": "PMID-10364157_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
67,
... | [] | [] | [
{
"id": "PMID-10364157_R1",
"type": "Protein-Component",
"arg1_id": "PMID-10364157_T14",
"arg2_id": "PMID-10364157_T19",
"normalized": []
}
] |
2 | PMID-9223506 | [
{
"id": "PMID-9223506__text",
"type": "abstract",
"text": [
"Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity. \nWhen transcriptionally active, the human immunodeficiency virus (HIV) promoter conta... | [
{
"id": "PMID-9223506_T1",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
649,
652
]
],
"normalized": []
},
{
"id": "PMID-9223506_T2",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
1213,
12... | [] | [] | [
{
"id": "PMID-9223506_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9223506_T1",
"arg2_id": "PMID-9223506_T16",
"normalized": []
}
] |
3 | PMID-9299590 | [
{
"id": "PMID-9299590__text",
"type": "abstract",
"text": [
"The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription. \nRel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulator... | [
{
"id": "PMID-9299590_T1",
"type": "Entity",
"text": [
"NF-kappa B"
],
"offsets": [
[
16,
26
]
],
"normalized": []
},
{
"id": "PMID-9299590_T2",
"type": "Entity",
"text": [
"Rel/NF-kappa B"
],
"offsets": [
[
10... | [] | [] | [] |
4 | PMID-9121455 | [
{
"id": "PMID-9121455__text",
"type": "abstract",
"text": [
"Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain. \nThe nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of ... | [
{
"id": "PMID-9121455_T1",
"type": "Protein",
"text": [
"NFATx1"
],
"offsets": [
[
11,
17
]
],
"normalized": []
},
{
"id": "PMID-9121455_T2",
"type": "Protein",
"text": [
"NFATx1"
],
"offsets": [
[
260,
... | [] | [] | [
{
"id": "PMID-9121455_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9121455_T4",
"arg2_id": "PMID-9121455_T20",
"normalized": []
},
{
"id": "PMID-9121455_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9121455_T4",
"arg2_id": "PMID-9121455_T21",
"normalized": []
... |
5 | PMID-10358154 | [
{
"id": "PMID-10358154__text",
"type": "abstract",
"text": [
"New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. \nWe had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro. We have now inv... | [
{
"id": "PMID-10358154_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "PMID-10358154_T2",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
742,
7... | [] | [] | [] |
6 | PMID-1618911 | [
{
"id": "PMID-1618911__text",
"type": "abstract",
"text": [
"Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins. \nThe NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to regulation of genes involve... | [
{
"id": "PMID-1618911_T1",
"type": "Protein",
"text": [
"rel"
],
"offsets": [
[
165,
168
]
],
"normalized": []
},
{
"id": "PMID-1618911_T2",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
964,
967... | [] | [] | [
{
"id": "PMID-1618911_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-1618911_T2",
"arg2_id": "PMID-1618911_T18",
"normalized": []
}
] |
7 | PMID-9862666 | [
{
"id": "PMID-9862666__text",
"type": "abstract",
"text": [
"Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. \nIL-2 gene transcription in T cells requires both TCR and costimulatory signals. IL-2 promoter acti... | [
{
"id": "PMID-9862666_T1",
"type": "Protein",
"text": [
"IL-2"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "PMID-9862666_T2",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
108,
112... | [] | [] | [
{
"id": "PMID-9862666_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9862666_T1",
"arg2_id": "PMID-9862666_T12",
"normalized": []
},
{
"id": "PMID-9862666_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9862666_T4",
"arg2_id": "PMID-9862666_T14",
"normalized": []
... |
8 | PMID-8929546 | [
{
"id": "PMID-8929546__text",
"type": "abstract",
"text": [
"Regulation of cytokine and cytokine receptor expression by glucocorticoids. \nGlucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttr... | [
{
"id": "PMID-8929546_T1",
"type": "Protein",
"text": [
"transforming growth factor-beta"
],
"offsets": [
[
311,
342
]
],
"normalized": []
},
{
"id": "PMID-8929546_T2",
"type": "Entity",
"text": [
"cytokine genes"
],
"offset... | [] | [] | [] |
9 | PMID-10225377 | [
{
"id": "PMID-10225377__text",
"type": "abstract",
"text": [
"Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2. \nIn monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phos... | [
{
"id": "PMID-10225377_T1",
"type": "Protein",
"text": [
"interleukin-1beta"
],
"offsets": [
[
690,
707
]
],
"normalized": []
},
{
"id": "PMID-10225377_T2",
"type": "Protein",
"text": [
"interleukin-1beta"
],
"offsets": [
... | [] | [] | [] |
10 | PMID-9252117 | [
{
"id": "PMID-9252117__text",
"type": "abstract",
"text": [
"EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. \nEarly B cell factor (EBF) and E47 participate in the transcriptional control of early B lymphocyte differentiation. With the aim... | [
{
"id": "PMID-9252117_T1",
"type": "Protein",
"text": [
"EBF"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "PMID-9252117_T2",
"type": "Protein",
"text": [
"E47"
],
"offsets": [
[
8,
11
... | [] | [
{
"id": "PMID-9252117_1",
"entity_ids": [
"PMID-9252117_T3",
"PMID-9252117_T4"
]
}
] | [
{
"id": "PMID-9252117_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-9252117_T7",
"arg2_id": "PMID-9252117_T19",
"normalized": []
},
{
"id": "PMID-9252117_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9252117_T14",
"arg2_id": "PMID-9252117_T22",
"normalized": []
... |
11 | PMID-8428966 | [
{
"id": "PMID-8428966__text",
"type": "abstract",
"text": [
"Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. \nThe lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cell... | [
{
"id": "PMID-8428966_T1",
"type": "Protein",
"text": [
"Fra-1"
],
"offsets": [
[
900,
905
]
],
"normalized": []
},
{
"id": "PMID-8428966_T2",
"type": "Protein",
"text": [
"cJun"
],
"offsets": [
[
1083,
... | [] | [] | [] |
12 | PMID-7892566 | [
{
"id": "PMID-7892566__text",
"type": "abstract",
"text": [
"[Regulation of transcription of the interleukin-2 gene in B-lymphocytes] \nSince most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements... | [
{
"id": "PMID-7892566_T1",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
36,
49
]
],
"normalized": []
},
{
"id": "PMID-7892566_T2",
"type": "Protein",
"text": [
"interleukin-2"
],
"offsets": [
[
... | [] | [] | [
{
"id": "PMID-7892566_R1",
"type": "Protein-Component",
"arg1_id": "PMID-7892566_T3",
"arg2_id": "PMID-7892566_T6",
"normalized": []
},
{
"id": "PMID-7892566_R2",
"type": "Protein-Component",
"arg1_id": "PMID-7892566_T5",
"arg2_id": "PMID-7892566_T10",
"normalized": []
... |
13 | PMID-8977228 | [
{
"id": "PMID-8977228__text",
"type": "abstract",
"text": [
"The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication. \nThe molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monoc... | [
{
"id": "PMID-8977228_T1",
"type": "Protein",
"text": [
"IL-4"
],
"offsets": [
[
80,
84
]
],
"normalized": []
},
{
"id": "PMID-8977228_T2",
"type": "Protein",
"text": [
"IL-13"
],
"offsets": [
[
89,
94
... | [] | [] | [] |
14 | PMID-9317151 | [
{
"id": "PMID-9317151__text",
"type": "abstract",
"text": [
"Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions. \nHuman phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor. This study tested t... | [
{
"id": "PMID-9317151_T1",
"type": "Protein",
"text": [
"CD14"
],
"offsets": [
[
171,
175
]
],
"normalized": []
},
{
"id": "PMID-9317151_T2",
"type": "Protein",
"text": [
"mCD14"
],
"offsets": [
[
177,
... | [] | [
{
"id": "PMID-9317151_1",
"entity_ids": [
"PMID-9317151_T1",
"PMID-9317151_T2"
]
},
{
"id": "PMID-9317151_2",
"entity_ids": [
"PMID-9317151_T7",
"PMID-9317151_T8"
]
}
] | [] |
15 | PMID-9712026 | [
{
"id": "PMID-9712026__text",
"type": "abstract",
"text": [
"A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement. \nStimulation of resting human T cells with the CD28-specific mAb BW 828 induces proliferation and cytokine synth... | [
{
"id": "PMID-9712026_T1",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
2,
6
]
],
"normalized": []
},
{
"id": "PMID-9712026_T2",
"type": "Protein",
"text": [
"CD28"
],
"offsets": [
[
171,
175
... | [] | [] | [
{
"id": "PMID-9712026_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9712026_T8",
"arg2_id": "PMID-9712026_T20",
"normalized": []
},
{
"id": "PMID-9712026_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9712026_T8",
"arg2_id": "PMID-9712026_T21",
"normalized": []
... |
16 | PMID-8158122 | [
{
"id": "PMID-8158122__text",
"type": "abstract",
"text": [
"Activation of nuclear factor kappa B in human neuroblastoma cell lines. \nThe nuclear factor kappa B (NF-kappa B) is a eukaryotic transcription factor. In B cells and macrophages it is constitutively present in cell nuclei, whereas in ma... | [
{
"id": "PMID-8158122_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
336,
363
]
],
"normalized": []
},
{
"id": "PMID-8158122_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [
{
"id": "PMID-8158122_1",
"entity_ids": [
"PMID-8158122_T1",
"PMID-8158122_T2"
]
}
] | [] |
17 | PMID-8663022 | [
{
"id": "PMID-8663022__text",
"type": "abstract",
"text": [
"Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter. \nPU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid and B cells, activates many B cell and my... | [
{
"id": "PMID-8663022_T1",
"type": "Protein",
"text": [
"PU.1"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "PMID-8663022_T2",
"type": "Protein",
"text": [
"spi-1"
],
"offsets": [
[
76,
81
... | [] | [
{
"id": "PMID-8663022_1",
"entity_ids": [
"PMID-8663022_T1",
"PMID-8663022_T2"
]
},
{
"id": "PMID-8663022_2",
"entity_ids": [
"PMID-8663022_T3",
"PMID-8663022_T4"
]
},
{
"id": "PMID-8663022_3",
"entity_ids": [
"PMID-8663022_T12",
"PMID-8663... | [
{
"id": "PMID-8663022_R1",
"type": "Protein-Component",
"arg1_id": "PMID-8663022_T1",
"arg2_id": "PMID-8663022_T20",
"normalized": []
},
{
"id": "PMID-8663022_R2",
"type": "Protein-Component",
"arg1_id": "PMID-8663022_T5",
"arg2_id": "PMID-8663022_T22",
"normalized": []
... |
18 | PMID-9136080 | [
{
"id": "PMID-9136080__text",
"type": "abstract",
"text": [
"Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression. \nThe human myeloid nuclear differen... | [
{
"id": "PMID-9136080_T1",
"type": "Protein",
"text": [
"myeloid cell nuclear differentiation antigen"
],
"offsets": [
[
45,
89
]
],
"normalized": []
},
{
"id": "PMID-9136080_T2",
"type": "Protein",
"text": [
"Sp1"
],
"offse... | [] | [
{
"id": "PMID-9136080_1",
"entity_ids": [
"PMID-9136080_T5",
"PMID-9136080_T6"
]
}
] | [
{
"id": "PMID-9136080_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9136080_T1",
"arg2_id": "PMID-9136080_T20",
"normalized": []
}
] |
19 | PMID-9416887 | [
{
"id": "PMID-9416887__text",
"type": "abstract",
"text": [
"Cyclosporin A inhibits monocyte tissue factor activation in cardiac transplant recipients. \nBACKGROUND: Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation. Be... | [
{
"id": "PMID-9416887_T1",
"type": "Protein",
"text": [
"tissue factor"
],
"offsets": [
[
32,
45
]
],
"normalized": []
},
{
"id": "PMID-9416887_T2",
"type": "Protein",
"text": [
"tissue factor"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-9416887_1",
"entity_ids": [
"PMID-9416887_T2",
"PMID-9416887_T3"
]
}
] | [
{
"id": "PMID-9416887_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9416887_T14",
"arg2_id": "PMID-9416887_T20",
"normalized": []
}
] |
20 | PMID-9018153 | [
{
"id": "PMID-9018153__text",
"type": "abstract",
"text": [
"Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter. \nThe negative regulatory element (NRE) of the hepatitis B virus (HBV) core promoter cont... | [
{
"id": "PMID-9018153_T1",
"type": "Protein",
"text": [
"RFX1"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "PMID-9018153_T2",
"type": "Protein",
"text": [
"MIBP1"
],
"offsets": [
[
46,
51
... | [] | [] | [
{
"id": "PMID-9018153_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-9018153_T5",
"arg2_id": "PMID-9018153_T25",
"normalized": []
},
{
"id": "PMID-9018153_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-9018153_T6",
"arg2_id": "PMID-9018153_T25",
"normalized": []
}
] |
21 | PMID-9119025 | [
{
"id": "PMID-9119025__text",
"type": "abstract",
"text": [
"Cell-to-cell contact activates the long terminal repeat of human immunodeficiency virus 1 through its kappaB motif. \nCell-to-cell contact between peripheral blood lymphocytes and transfected human colonic carcinoma cell line HT29 activa... | [
{
"id": "PMID-9119025_T1",
"type": "Protein",
"text": [
"p50"
],
"offsets": [
[
770,
773
]
],
"normalized": []
},
{
"id": "PMID-9119025_T2",
"type": "Protein",
"text": [
"p65"
],
"offsets": [
[
774,
777... | [] | [] | [
{
"id": "PMID-9119025_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-9119025_T1",
"arg2_id": "PMID-9119025_T14",
"normalized": []
},
{
"id": "PMID-9119025_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-9119025_T2",
"arg2_id": "PMID-9119025_T14",
"normalized": []
}
] |
22 | PMID-7859743 | [
{
"id": "PMID-7859743__text",
"type": "abstract",
"text": [
"HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. \nThis study demonstrates that human immunodeficiency virus type 1 (HIV-1) Tat protein amplifies the activity of tumor necrosi... | [
{
"id": "PMID-7859743_T1",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
6,
9
]
],
"normalized": []
},
{
"id": "PMID-7859743_T2",
"type": "Protein",
"text": [
"Tat"
],
"offsets": [
[
185,
188
... | [] | [
{
"id": "PMID-7859743_1",
"entity_ids": [
"PMID-7859743_T7",
"PMID-7859743_T8"
]
}
] | [
{
"id": "PMID-7859743_R1",
"type": "Protein-Component",
"arg1_id": "PMID-7859743_T14",
"arg2_id": "PMID-7859743_T25",
"normalized": []
}
] |
23 | PMID-10233927 | [
{
"id": "PMID-10233927__text",
"type": "abstract",
"text": [
"Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus. \nInfection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth. To interpret the mechanisms b... | [
{
"id": "PMID-10233927_T1",
"type": "Protein",
"text": [
"cyclin D2"
],
"offsets": [
[
459,
468
]
],
"normalized": []
},
{
"id": "PMID-10233927_T2",
"type": "Protein",
"text": [
"E2F-4"
],
"offsets": [
[
537,
... | [] | [] | [] |
24 | PMID-7659529 | [
{
"id": "PMID-7659529__text",
"type": "abstract",
"text": [
"Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs. \nErythropoietin (Epo), the primary regulator of the production of erythroid cells, acts by binding to a cell surface rec... | [
{
"id": "PMID-7659529_T1",
"type": "Protein",
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41,
64
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],
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},
{
"id": "PMID-7659529_T2",
"type": "Protein",
"text": [
"GATA-1"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-7659529_1",
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"PMID-7659529_T4",
"PMID-7659529_T5"
]
}
] | [
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"type": "Protein-Component",
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"arg2_id": "PMID-7659529_T30",
"normalized": []
... |
25 | PMID-8179594 | [
{
"id": "PMID-8179594__text",
"type": "abstract",
"text": [
"Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos. \nThe transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-... | [
{
"id": "PMID-8179594_T1",
"type": "Protein",
"text": [
"c-fos"
],
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84,
89
]
],
"normalized": []
},
{
"id": "PMID-8179594_T2",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
365,
3... | [] | [] | [
{
"id": "PMID-8179594_R1",
"type": "Subunit-Complex",
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"arg2_id": "PMID-8179594_T11",
"normalized": []
},
{
"id": "PMID-8179594_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-8179594_T2",
"arg2_id": "PMID-8179594_T11",
"normalized": []
},
... |
26 | PMID-8562886 | [
{
"id": "PMID-8562886__text",
"type": "abstract",
"text": [
"The effect of Toremifene on the expression of some genes in human mononuclear cells. \nToremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells. After short-term, in vitro exposure to the... | [
{
"id": "PMID-8562886_T1",
"type": "Protein",
"text": [
"p53"
],
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310,
313
]
],
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},
{
"id": "PMID-8562886_T2",
"type": "Protein",
"text": [
"Bcl-2"
],
"offsets": [
[
318,
3... | [] | [] | [] |
27 | PMID-8725939 | [
{
"id": "PMID-8725939__text",
"type": "abstract",
"text": [
"Regulation of gene expression at early stages of B-cell and T-cell differentiation. \nThe expression of distinct sets of genes at different stages of B-lymphocyte and T-lymphocyte differentiation is controlled at the level of transcripti... | [
{
"id": "PMID-8725939_T1",
"type": "Entity",
"text": [
"genes"
],
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[
120,
125
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],
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},
{
"id": "PMID-8725939_T2",
"type": "Entity",
"text": [
"higher order nucleoprotein complexes"
],
"offsets": [... | [] | [] | [] |
28 | PMID-8577772 | [
{
"id": "PMID-8577772__text",
"type": "abstract",
"text": [
"In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors. \nAnergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult. In vivo, anergy has mainly been studied at the ... | [
{
"id": "PMID-8577772_T1",
"type": "Protein",
"text": [
"CD4"
],
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[
18,
21
]
],
"normalized": []
},
{
"id": "PMID-8577772_T2",
"type": "Protein",
"text": [
"staphylococcal enterotoxin A"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-8577772_1",
"entity_ids": [
"PMID-8577772_T2",
"PMID-8577772_T3"
]
},
{
"id": "PMID-8577772_2",
"entity_ids": [
"PMID-8577772_T6",
"PMID-8577772_T7"
]
}
] | [
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"arg2_id": "PMID-8577772_T26",
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},
{
"id": "PMID-8577772_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-8577772_T18",
"arg2_id": "PMID-8577772_T28",
"normalized": []
... |
29 | PMID-1645452 | [
{
"id": "PMID-1645452__text",
"type": "abstract",
"text": [
"The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitami... | [
{
"id": "PMID-1645452_T1",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
[
174,
192
]
],
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},
{
"id": "PMID-1645452_T2",
"type": "Protein",
"text": [
"interleukin-1 beta"
],
"offsets": [
... | [] | [
{
"id": "PMID-1645452_1",
"entity_ids": [
"PMID-1645452_T2",
"PMID-1645452_T3"
]
}
] | [] |
30 | PMID-10233882 | [
{
"id": "PMID-10233882__text",
"type": "abstract",
"text": [
"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival. \nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in... | [
{
"id": "PMID-10233882_T1",
"type": "Protein",
"text": [
"CD34"
],
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[
41,
45
]
],
"normalized": []
},
{
"id": "PMID-10233882_T2",
"type": "Protein",
"text": [
"CD34"
],
"offsets": [
[
360,
3... | [] | [] | [] |
31 | PMID-8960112 | [
{
"id": "PMID-8960112__text",
"type": "abstract",
"text": [
"Lymphocytes from CML patients lack a 47 kDa factor having affinity for a genomic sterol regulatory sequence. \nDeranged cellular cholesterol homeostasis has been widely recognized in the initiation as well as progression of various types... | [
{
"id": "PMID-8960112_T1",
"type": "Protein",
"text": [
"LDL receptor"
],
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[
842,
854
]
],
"normalized": []
},
{
"id": "PMID-8960112_T2",
"type": "Entity",
"text": [
"genomic sterol regulatory sequence"
],
"offse... | [] | [] | [] |
32 | PMID-7890658 | [
{
"id": "PMID-7890658__text",
"type": "abstract",
"text": [
"Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721] \nA DNA response element (... | [
{
"id": "PMID-7890658_T1",
"type": "Protein",
"text": [
"chloramphenicol acetyl-transferase"
],
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[
711,
745
]
],
"normalized": []
},
{
"id": "PMID-7890658_T2",
"type": "Entity",
"text": [
"human TR2 orphan receptor respo... | [] | [] | [] |
33 | PMID-8871649 | [
{
"id": "PMID-8871649__text",
"type": "abstract",
"text": [
"A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene. \nThis study was designed to determine the potential cis-elements involved in transcriptional regulation of ... | [
{
"id": "PMID-8871649_T1",
"type": "Protein",
"text": [
"Sp1"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "PMID-8871649_T2",
"type": "Protein",
"text": [
"perforin"
],
"offsets": [
[
114,
... | [] | [
{
"id": "PMID-8871649_1",
"entity_ids": [
"PMID-8871649_T6",
"PMID-8871649_T7"
]
}
] | [
{
"id": "PMID-8871649_R1",
"type": "Protein-Component",
"arg1_id": "PMID-8871649_T3",
"arg2_id": "PMID-8871649_T15",
"normalized": []
},
{
"id": "PMID-8871649_R2",
"type": "Protein-Component",
"arg1_id": "PMID-8871649_T4",
"arg2_id": "PMID-8871649_T21",
"normalized": []
... |
34 | PMID-7525701 | [
{
"id": "PMID-7525701__text",
"type": "abstract",
"text": [
"Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B. \nThe B cell-associated surface molecule CD40 functions to regulate B cell responses. Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 product... | [
{
"id": "PMID-7525701_T1",
"type": "Protein",
"text": [
"CD40"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "PMID-7525701_T2",
"type": "Protein",
"text": [
"CD40"
],
"offsets": [
[
112,
116... | [] | [
{
"id": "PMID-7525701_1",
"entity_ids": [
"PMID-7525701_T8",
"PMID-7525701_T9"
]
}
] | [] |
35 | PMID-2278044 | [
{
"id": "PMID-2278044__text",
"type": "abstract",
"text": [
"Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. \nTwo consensus sequences, called X and Y boxes, capable of binding nuclear proteins and regulating expression in B cells have been... | [
{
"id": "PMID-2278044_T1",
"type": "Protein",
"text": [
"OTF-1"
],
"offsets": [
[
652,
657
]
],
"normalized": []
},
{
"id": "PMID-2278044_T2",
"type": "Protein",
"text": [
"OTF-2"
],
"offsets": [
[
682,
... | [] | [] | [] |
36 | PMID-9765295 | [
{
"id": "PMID-9765295__text",
"type": "abstract",
"text": [
"Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras. \nReceptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cell... | [
{
"id": "PMID-9765295_T1",
"type": "Protein",
"text": [
"Raf-1"
],
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[
1097,
1102
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],
"normalized": []
},
{
"id": "PMID-9765295_T2",
"type": "Entity",
"text": [
"Fc portion"
],
"offsets": [
[
125,
... | [] | [] | [] |
37 | PMID-1956769 | [
{
"id": "PMID-1956769__text",
"type": "abstract",
"text": [
"Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1. \nTwo different proteins which independently bound to neighboring sequences within the negativ... | [
{
"id": "PMID-1956769_T1",
"type": "Entity",
"text": [
"negative regulatory element"
],
"offsets": [
[
71,
98
]
],
"normalized": []
},
{
"id": "PMID-1956769_T2",
"type": "Entity",
"text": [
"neighboring sequences"
],
"offset... | [] | [] | [] |
38 | PMID-7635985 | [
{
"id": "PMID-7635985__text",
"type": "abstract",
"text": [
"Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the invo... | [
{
"id": "PMID-7635985_T1",
"type": "Protein",
"text": [
"Interleukin 4"
],
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[
0,
13
]
],
"normalized": []
},
{
"id": "PMID-7635985_T2",
"type": "Protein",
"text": [
"interferon-gamma"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-7635985_1",
"entity_ids": [
"PMID-7635985_T11",
"PMID-7635985_T12"
]
},
{
"id": "PMID-7635985_2",
"entity_ids": [
"PMID-7635985_T15",
"PMID-7635985_T16"
]
}
] | [
{
"id": "PMID-7635985_R1",
"type": "Protein-Component",
"arg1_id": "PMID-7635985_T2",
"arg2_id": "PMID-7635985_T25",
"normalized": []
},
{
"id": "PMID-7635985_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-7635985_T13",
"arg2_id": "PMID-7635985_T30",
"normalized": []
... |
39 | PMID-9428992 | [
{
"id": "PMID-9428992__text",
"type": "abstract",
"text": [
"Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation. \nFetal and neonatal lymphocytes are relatively resistant to activation and cytok... | [
{
"id": "PMID-9428992_T1",
"type": "Protein",
"text": [
"c-fos"
],
"offsets": [
[
24,
29
]
],
"normalized": []
},
{
"id": "PMID-9428992_T2",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
31,
36... | [] | [] | [
{
"id": "PMID-9428992_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-9428992_T7",
"arg2_id": "PMID-9428992_T13",
"normalized": []
},
{
"id": "PMID-9428992_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9428992_T11",
"arg2_id": "PMID-9428992_T18",
"normalized": []
... |
40 | PMID-9725220 | [
{
"id": "PMID-9725220__text",
"type": "abstract",
"text": [
"Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells. \nNF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF... | [
{
"id": "PMID-9725220_T1",
"type": "Protein",
"text": [
"NF-IL6"
],
"offsets": [
[
45,
51
]
],
"normalized": []
},
{
"id": "PMID-9725220_T2",
"type": "Protein",
"text": [
"SP1"
],
"offsets": [
[
86,
89
... | [] | [] | [
{
"id": "PMID-9725220_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9725220_T1",
"arg2_id": "PMID-9725220_T10",
"normalized": []
},
{
"id": "PMID-9725220_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9725220_T7",
"arg2_id": "PMID-9725220_T12",
"normalized": []
... |
41 | PMID-2105946 | [
{
"id": "PMID-2105946__text",
"type": "abstract",
"text": [
"Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. \nAP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimul... | [
{
"id": "PMID-2105946_T1",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
55,
60
]
],
"normalized": []
},
{
"id": "PMID-2105946_T2",
"type": "Protein",
"text": [
"c-jun"
],
"offsets": [
[
172,
1... | [] | [] | [
{
"id": "PMID-2105946_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-2105946_T2",
"arg2_id": "PMID-2105946_T13",
"normalized": []
}
] |
42 | PMID-1907460 | [
{
"id": "PMID-1907460__text",
"type": "abstract",
"text": [
"Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives. \nHIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B. HIV-1-infected individuals have, on average, abnormall... | [
{
"id": "PMID-1907460_T1",
"type": "Protein",
"text": [
"tumour necrosis factor alpha"
],
"offsets": [
[
253,
281
]
],
"normalized": []
},
{
"id": "PMID-1907460_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [
{
"id": "PMID-1907460_1",
"entity_ids": [
"PMID-1907460_T1",
"PMID-1907460_T2"
]
},
{
"id": "PMID-1907460_2",
"entity_ids": [
"PMID-1907460_T3",
"PMID-1907460_T4"
]
}
] | [] |
43 | PMID-9032265 | [
{
"id": "PMID-9032265__text",
"type": "abstract",
"text": [
"Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation. \nThe ferritin H-chain gene ... | [
{
"id": "PMID-9032265_T1",
"type": "Protein",
"text": [
"ferritin H-chain"
],
"offsets": [
[
214,
230
]
],
"normalized": []
},
{
"id": "PMID-9032265_T2",
"type": "Protein",
"text": [
"ferritin H"
],
"offsets": [
[
... | [] | [] | [
{
"id": "PMID-9032265_R1",
"type": "Protein-Component",
"arg1_id": "PMID-9032265_T1",
"arg2_id": "PMID-9032265_T6",
"normalized": []
},
{
"id": "PMID-9032265_R2",
"type": "Protein-Component",
"arg1_id": "PMID-9032265_T2",
"arg2_id": "PMID-9032265_T10",
"normalized": []
... |
44 | PMID-9837745 | [
{
"id": "PMID-9837745__text",
"type": "abstract",
"text": [
"Interleukin-12 expression in B cells by transformation with Epstein-Barr virus. \nAlthough interleukin (IL)-12 was originally purified from an Epstein-Barr (EBV)-transformed B cell line and the high correlation of EBV infection and IL-12... | [
{
"id": "PMID-9837745_T1",
"type": "Protein",
"text": [
"p40"
],
"offsets": [
[
533,
536
]
],
"normalized": []
},
{
"id": "PMID-9837745_T2",
"type": "Protein",
"text": [
"latent membrane protein 1"
],
"offsets": [
[
... | [] | [
{
"id": "PMID-9837745_1",
"entity_ids": [
"PMID-9837745_T2",
"PMID-9837745_T3"
]
}
] | [] |
45 | PMID-7594468 | [
{
"id": "PMID-7594468__text",
"type": "abstract",
"text": [
"Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. \nThe Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-k... | [
{
"id": "PMID-7594468_T1",
"type": "Protein",
"text": [
"IkB alpha"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "PMID-7594468_T2",
"type": "Protein",
"text": [
"IkB alpha"
],
"offsets": [
[
660,
... | [] | [] | [] |
46 | PMID-10202024 | [
{
"id": "PMID-10202024__text",
"type": "abstract",
"text": [
"Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression. \nTo continue our investigation of the cellular events that occur following human CMV (HCMV) infection, we focused on the regulation of cellular ... | [
{
"id": "PMID-10202024_T1",
"type": "Protein",
"text": [
"IL-1beta"
],
"offsets": [
[
370,
378
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],
"normalized": []
},
{
"id": "PMID-10202024_T2",
"type": "Protein",
"text": [
"A20"
],
"offsets": [
[
380,
... | [] | [] | [
{
"id": "PMID-10202024_R1",
"type": "Subunit-Complex",
"arg1_id": "PMID-10202024_T3",
"arg2_id": "PMID-10202024_T11",
"normalized": []
},
{
"id": "PMID-10202024_R2",
"type": "Subunit-Complex",
"arg1_id": "PMID-10202024_T4",
"arg2_id": "PMID-10202024_T11",
"normalized": []... |
47 | PMID-8573121 | [
{
"id": "PMID-8573121__text",
"type": "abstract",
"text": [
"Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione. \nNuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor. Redox regulation of NF-kappa B has been implicated in the activation of... | [
{
"id": "PMID-8573121_T1",
"type": "Protein",
"text": [
"tumor necrosis factor alpha"
],
"offsets": [
[
848,
875
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],
"normalized": []
},
{
"id": "PMID-8573121_T2",
"type": "Protein",
"text": [
"TNF alpha"
],
"offsets": [
... | [] | [
{
"id": "PMID-8573121_1",
"entity_ids": [
"PMID-8573121_T1",
"PMID-8573121_T2"
]
}
] | [] |
48 | PMID-10229841 | [
{
"id": "PMID-10229841__text",
"type": "abstract",
"text": [
"Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha. \nThe level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogene... | [
{
"id": "PMID-10229841_T1",
"type": "Protein",
"text": [
"lymphotoxin-beta receptor"
],
"offsets": [
[
22,
47
]
],
"normalized": []
},
{
"id": "PMID-10229841_T2",
"type": "Protein",
"text": [
"TNF-alpha"
],
"offsets": [
... | [] | [
{
"id": "PMID-10229841_1",
"entity_ids": [
"PMID-10229841_T4",
"PMID-10229841_T5"
]
}
] | [] |
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Dataset Card for BioNLP 2011 REL
The Entity Relations (REL) task is a supporting task of the BioNLP Shared Task 2011. The task concerns the extraction of two types of part-of relations between a gene/protein and an associated entity.
Citation Information
@inproceedings{10.5555/2107691.2107703,
author = {Pyysalo, Sampo and Ohta, Tomoko and Tsujii, Jun'ichi},
title = {Overview of the Entity Relations (REL) Supporting Task of BioNLP Shared Task 2011},
year = {2011},
isbn = {9781937284091},
publisher = {Association for Computational Linguistics},
address = {USA},
abstract = {This paper presents the Entity Relations (REL) task,
a supporting task of the BioNLP Shared Task 2011. The task concerns
the extraction of two types of part-of relations between a gene/protein
and an associated entity. Four teams submitted final results for
the REL task, with the highest-performing system achieving 57.7%
F-score. While experiments suggest use of the data can help improve
event extraction performance, the task data has so far received only
limited use in support of event extraction. The REL task continues
as an open challenge, with all resources available from the shared
task website.},
booktitle = {Proceedings of the BioNLP Shared Task 2011 Workshop},
pages = {83–88},
numpages = {6},
location = {Portland, Oregon},
series = {BioNLP Shared Task '11}
}
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