license: mit
configs:
- config_name: dataset
data_files: dataset.csv
Description
This dataset contains 160000 sequences of four site mutation of an enzyme active site. The enzyme is β-subunit of tryptophan synthase (TrpB), which synthesizes L-tryptophan (Trp) from indole and L-serine (Ser). The parent enzyme is TrpB variant Tm9D8*. Tm9D8* differs from wildtype TmTrpB by ten amino acid substitutions (P19G, E30G, I69V, K96L, P140L, N167D, I184F, L213P, G228S, and T292S). The 4-sitesaturation library targeted two pairs of positions: 183/184 and 227/228.
Splits
traing: 128000
valid: 16000
test: 16000
Related paper
The dataset is from A combinatorially complete epistatic fitness landscape in an enzyme active site.
Label
Label means mutation fitness, here represents growth rate of E. coli strain. The maximum fitness of this landscape is 1, the closer to 1, the better fitness.