uuid
stringlengths 4
8
| template_uuid
stringclasses 40
values | question
stringlengths 13
193
| answer
stringlengths 29
2.2k
| benchmark_query
stringlengths 138
627
| execution_results
stringlengths 2
1.14M
| query_type
stringclasses 2
values | sql_category
stringclasses 26
values | bio_category
stringclasses 14
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|---|---|---|---|---|---|---|---|---|
Q1.131
|
Q1
|
Is CA12 a druggable gene?
|
There are currently 5 approved drugs which target CA12, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CA12 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_255', 'drugName': 'Dichlorphenamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6140', 'drugName': 'Acetazolamide Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA4 (ENSG00000167434), CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6141', 'drugName': 'Acetazolamide Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA4 (ENSG00000167434), CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6142', 'drugName': 'Acetazolamide Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA4 (ENSG00000167434), CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6095', 'drugName': 'Sulthiame', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3089', 'drugName': 'Ethoxzolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_257', 'drugName': 'Dichlorphenamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_469', 'drugName': 'Acetazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434), CA1 (ENSG00000133742)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_467', 'drugName': 'Acetazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434), CA1 (ENSG00000133742)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_466', 'drugName': 'Acetazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434), CA1 (ENSG00000133742)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6143', 'drugName': 'Acetazolamide Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA4 (ENSG00000167434), CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_256', 'drugName': 'Dichlorphenamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_254', 'drugName': 'Dichlorphenamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_468', 'drugName': 'Acetazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA12 (ENSG00000074410), CA2 (ENSG00000104267), CA4 (ENSG00000167434), CA1 (ENSG00000133742)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1041
|
Q1
|
Is PDE10A a druggable gene?
|
There are currently 2 approved drugs which target PDE10A, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PDE10A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4263', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6107', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6106', 'drugName': 'Dipyridamole', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408), SLC29A1 (ENSG00000112759)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4264', 'drugName': 'Pentoxifylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADORA2B (ENSG00000170425), ADORA2A (ENSG00000128271), PDE5A (ENSG00000138735), PDE4A (ENSG00000065989), PDE3A (ENSG00000172572), PDE6H (ENSG00000139053), PDE6G (ENSG00000185527), PDE2A (ENSG00000186642), PDE7A (ENSG00000205268), PDE1A (ENSG00000115252), PDE9A (ENSG00000160191), PDE6B (ENSG00000133256), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE6D (ENSG00000156973), PDE6A (ENSG00000132915), PDE3B (ENSG00000152270), PDE6C (ENSG00000095464), PDE8B (ENSG00000113231), PDE10A (ENSG00000112541), PDE1B (ENSG00000123360), PDE4C (ENSG00000105650), PDE1C (ENSG00000154678), PDE8A (ENSG00000073417), PDE7B (ENSG00000171408)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5712', 'drugName': 'Ibudilast', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE10A (ENSG00000112541), PDE5A (ENSG00000138735)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5713', 'drugName': 'Ibudilast', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE10A (ENSG00000112541), PDE5A (ENSG00000138735)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5714', 'drugName': 'Ibudilast', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE10A (ENSG00000112541), PDE5A (ENSG00000138735)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5715', 'drugName': 'Ibudilast', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE10A (ENSG00000112541), PDE5A (ENSG00000138735)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4557', 'drugName': 'Balipodect', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE10A (ENSG00000112541)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4386', 'drugName': 'Mardepodect', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE10A (ENSG00000112541)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_408', 'drugName': 'Pbf-999', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE10A (ENSG00000112541), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_409', 'drugName': 'Pbf-999', 'drugIsApproved': False, 'newLinkedTargets_string': 'PDE10A (ENSG00000112541), ADORA2A (ENSG00000128271)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.333
|
Q1
|
Is CTSS a druggable gene?
|
There are currently no approved drugs targeting CTSS, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CTSS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1222', 'drugName': 'Petesicatib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CTSS (ENSG00000163131)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.325
|
Q1
|
Is CSNK1E a druggable gene?
|
There are currently 2 approved drugs which target CSNK1E, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CSNK1E %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5649', 'drugName': 'Umbralisib', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3012', 'drugName': 'Umbralisib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3011', 'drugName': 'Umbralisib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5647', 'drugName': 'Umbralisib', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5648', 'drugName': 'Umbralisib', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3013', 'drugName': 'Umbralisib Tosylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CSNK1E (ENSG00000213923), PIK3CD (ENSG00000171608), ABL1 (ENSG00000097007)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1214
|
Q1
|
Is RBX1 a druggable gene?
|
There are currently 3 approved drugs which target RBX1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RBX1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_64', 'drugName': 'Thalidomide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CRBN (ENSG00000113851), DDB1 (ENSG00000167986), CUL4A (ENSG00000139842), RBX1 (ENSG00000100387)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4886', 'drugName': 'Pomalidomide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CRBN (ENSG00000113851), DDB1 (ENSG00000167986), CUL4A (ENSG00000139842), RBX1 (ENSG00000100387)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_456', 'drugName': 'Lenalidomide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CRBN (ENSG00000113851), DDB1 (ENSG00000167986), CUL4A (ENSG00000139842), RBX1 (ENSG00000100387)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_567', 'drugName': 'Iberdomide', 'drugIsApproved': False, 'newLinkedTargets_string': 'CRBN (ENSG00000113851), DDB1 (ENSG00000167986), CUL4A (ENSG00000139842), RBX1 (ENSG00000100387)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1471
|
Q1
|
Is TP53 a druggable gene?
|
There are currently no approved drugs targeting TP53, but there are 10 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TP53 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3191', 'drugName': 'Idasanutlin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510), MDM2 (ENSG00000135679)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4656', 'drugName': 'Teprasiran', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_590', 'drugName': 'Eprenetapopt', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2734', 'drugName': 'Cenersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1456', 'drugName': 'Apg115', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510), MDM2 (ENSG00000135679)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5302', 'drugName': 'Navtemadlin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510), MDM2 (ENSG00000135679)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5092', 'drugName': 'Contusugene Ladenovec', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3936', 'drugName': 'Siremadlin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510), MDM2 (ENSG00000135679)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_444', 'drugName': 'Cenersen Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2015', 'drugName': 'Teprasiran Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'TP53 (ENSG00000141510)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.772
|
Q1
|
Is KCNK9 a druggable gene?
|
There are currently 7 approved drugs which target KCNK9, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNK9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5595', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5598', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5599', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5600', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3262', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3263', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ 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(ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_216', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5043', 'drugName': 'Halothane', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3265', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5597', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5943', 'drugName': 'Doxapram', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK3 (ENSG00000171303), KCNK9 (ENSG00000169427)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6167', 'drugName': 'Doxapram Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK3 (ENSG00000171303), KCNK9 (ENSG00000169427)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6166', 'drugName': 'Doxapram Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK3 (ENSG00000171303), KCNK9 (ENSG00000169427)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_215', 'drugName': 'Enflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK10 (ENSG00000100433)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2920', 'drugName': 'Sevoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), KCNK2 (ENSG00000082482), KCNK10 (ENSG00000100433), KCNK18 (ENSG00000186795), KCNK3 (ENSG00000171303), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3261', 'drugName': 'Desflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK10 (ENSG00000100433), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK2 (ENSG00000082482), KCNK3 (ENSG00000171303), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5596', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5594', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), KCNK3 (ENSG00000171303), KCNK2 (ENSG00000082482), GLRA1 (ENSG00000145888), GLRB (ENSG00000109738), KCNK18 (ENSG00000186795)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5942', 'drugName': 'Doxapram', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK3 (ENSG00000171303), KCNK9 (ENSG00000169427)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.137
|
Q1
|
Is CA5A a druggable gene?
|
There are currently 2 approved drugs which target CA5A, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CA5A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_6095', 'drugName': 'Sulthiame', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3089', 'drugName': 'Ethoxzolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.711
|
Q1
|
Is INPP5D a druggable gene?
|
There are currently no approved drugs targeting INPP5D, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%INPP5D %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2977', 'drugName': 'Rosiptor', 'drugIsApproved': False, 'newLinkedTargets_string': 'INPP5D (ENSG00000168918)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.531
|
Q1
|
Is GPA33 a druggable gene?
|
There are currently no approved drugs targeting GPA33, but there are 3 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GPA33 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2310', 'drugName': 'A33 131I', 'drugIsApproved': False, 'newLinkedTargets_string': 'GPA33 (ENSG00000143167)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_231', 'drugName': 'Hua33', 'drugIsApproved': False, 'newLinkedTargets_string': 'GPA33 (ENSG00000143167)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3889', 'drugName': 'Krn-330', 'drugIsApproved': False, 'newLinkedTargets_string': 'GPA33 (ENSG00000143167)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.749
|
Q1
|
Is KCND3 a druggable gene?
|
There are currently 6 approved drugs which target KCND3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCND3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_719', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_718', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_717', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_716', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_715', 'drugName': 'Vernakalant', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCND3 (ENSG00000171385), KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1587', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1589', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1590', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1586', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1588', 'drugName': 'Vernakalant Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNA5 (ENSG00000130037), KCNJ3 (ENSG00000162989), KCNJ5 (ENSG00000120457), KCNH2 (ENSG00000055118), SCN5A (ENSG00000183873), KCND3 (ENSG00000171385)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.437
|
Q1
|
Is F13A1 a druggable gene?
|
There is 1 drug, Catridecacog, that targets F13A1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%F13A1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_886', 'drugName': 'Catridecacog', 'drugIsApproved': True, 'newLinkedTargets_string': 'F13A1 (ENSG00000124491)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.682
|
Q1
|
Is IL1A a druggable gene?
|
There are currently no approved drugs targeting IL1A, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2597', 'drugName': 'Bermekimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1A (ENSG00000115008)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_573', 'drugName': 'Lutikizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1A (ENSG00000115008), IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_574', 'drugName': 'Lutikizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1A (ENSG00000115008), IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1340
|
Q1
|
Is SCNN1A a druggable gene?
|
There are currently 3 approved drugs which target SCNN1A, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SCNN1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2590', 'drugName': 'Amiloride Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4230', 'drugName': 'Triamterene', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3975', 'drugName': 'Amiloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1778', 'drugName': 'Cofirasersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'SCNN1G (ENSG00000166828), SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4187', 'drugName': 'Idrevloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.160
|
Q1
|
Is CACNG1 a druggable gene?
|
There are currently 9 approved drugs which target CACNG1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CACNG1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_142', 'drugName': 'Gabapentin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4565', 'drugName': 'Bepridil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6291', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6292', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_311', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4910', 'drugName': 'Bepridil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2991', 'drugName': 'Pregabalin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1320', 'drugName': 'Phloroglucinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_310', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1799', 'drugName': 'Suloctidil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4133', 'drugName': 'Gabapentin Enacarbil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2281', 'drugName': 'Imagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2254', 'drugName': 'Atagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.595
|
Q1
|
Is HLA-DRB5 a druggable gene?
|
There are currently no approved drugs targeting HLA-DRB5, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HLA-DRB5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_363', 'drugName': 'Apolizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'HLA-DRB3 (ENSG00000231679), HLA-DRB5 (ENSG00000198502), HLA-DRB1 (ENSG00000196126), HLA-DRB4 (ENSG00000231021)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1221
|
Q1
|
Is RNPEP a druggable gene?
|
There are currently no approved drugs targeting RNPEP, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RNPEP %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), LAP3 (ENSG00000002549), METAP2 (ENSG00000111142), XPNPEP2 (ENSG00000122121), ERAP2 (ENSG00000164308), ERAP1 (ENSG00000164307), LVRN (ENSG00000172901), AOPEP (ENSG00000148120), METAP1D (ENSG00000172878), NPEPL1 (ENSG00000215440), RNPEPL1 (ENSG00000142327), XPNPEP3 (ENSG00000196236)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.197
|
Q1
|
Is CCR9 a druggable gene?
|
There are currently no approved drugs targeting CCR9, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CCR9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1403', 'drugName': 'Vercirnon', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCR9 (ENSG00000173585)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2090', 'drugName': 'Mln3126', 'drugIsApproved': False, 'newLinkedTargets_string': 'CCR9 (ENSG00000173585)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1272
|
Q1
|
Is RPLP0 a druggable gene?
|
There is 1 drug, Ataluren, that targets RPLP0, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPLP0 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.530
|
Q1
|
Is GP6 a druggable gene?
|
There are currently no approved drugs targeting GP6, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GP6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5071', 'drugName': 'Glenzocimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'GP6 (ENSG00000088053)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.412
|
Q1
|
Is EPHA5 a druggable gene?
|
There is 1 drug, Vandetanib, that targets EPHA5, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHA5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1936', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1934', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1932', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1931', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1937', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1935', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1933', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.98
|
Q1
|
Is AVPR2 a druggable gene?
|
There are currently 10 approved drugs which target AVPR2, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AVPR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2993', 'drugName': 'Desmopressin Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3359', 'drugName': 'Conivaptan Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5786', 'drugName': 'Vasopressin Tannate', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1B (ENSG00000198049), AVPR1A (ENSG00000166148)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1017', 'drugName': 'Desmopressin', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3226', 'drugName': 'Vasopressin', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5948', 'drugName': 'Terlipressin', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5949', 'drugName': 'Terlipressin', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5785', 'drugName': 'Vasopressin Tannate', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1B (ENSG00000198049), AVPR1A (ENSG00000166148)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5273', 'drugName': 'Argipressin Tannate', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2491', 'drugName': 'Lypressin', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148), AVPR1B (ENSG00000198049)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2594', 'drugName': 'Conivaptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2593', 'drugName': 'Conivaptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1A (ENSG00000166148)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5028', 'drugName': 'Tolvaptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5787', 'drugName': 'Vasopressin Tannate', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895), AVPR1B (ENSG00000198049), AVPR1A (ENSG00000166148)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3360', 'drugName': 'Conivaptan Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1788', 'drugName': 'Satavaptan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1193', 'drugName': 'Lixivaptan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_539', 'drugName': 'Pecavaptan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_540', 'drugName': 'Pecavaptan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AVPR1A (ENSG00000166148), AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2941', 'drugName': 'Mozavaptan', 'drugIsApproved': False, 'newLinkedTargets_string': 'AVPR2 (ENSG00000126895)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1484
|
Q1
|
Is TRPM8 a druggable gene?
|
There is 1 drug, Menthol, that targets TRPM8, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TRPM8 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5721', 'drugName': 'Menthol', 'drugIsApproved': True, 'newLinkedTargets_string': 'TRPA1 (ENSG00000104321), TRPM8 (ENSG00000144481)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5722', 'drugName': 'Menthol', 'drugIsApproved': True, 'newLinkedTargets_string': 'TRPA1 (ENSG00000104321), TRPM8 (ENSG00000144481)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_858', 'drugName': 'Elismetrep', 'drugIsApproved': False, 'newLinkedTargets_string': 'TRPM8 (ENSG00000144481)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2716', 'drugName': 'D-3263', 'drugIsApproved': False, 'newLinkedTargets_string': 'TRPM8 (ENSG00000144481)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.158
|
Q1
|
Is CACNB3 a druggable gene?
|
There are currently 9 approved drugs which target CACNB3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CACNB3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_142', 'drugName': 'Gabapentin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4565', 'drugName': 'Bepridil Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6291', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6292', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_311', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4910', 'drugName': 'Bepridil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2991', 'drugName': 'Pregabalin', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1320', 'drugName': 'Phloroglucinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_310', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1799', 'drugName': 'Suloctidil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4133', 'drugName': 'Gabapentin Enacarbil', 'drugIsApproved': True, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2281', 'drugName': 'Imagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2254', 'drugName': 'Atagabalin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.421
|
Q1
|
Is EPHX2 a druggable gene?
|
There are currently no approved drugs targeting EPHX2, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHX2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2804', 'drugName': 'Gsk2256294', 'drugIsApproved': False, 'newLinkedTargets_string': 'EPHX2 (ENSG00000120915)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_572', 'drugName': 'Ar9281', 'drugIsApproved': False, 'newLinkedTargets_string': 'EPHX2 (ENSG00000120915)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.995
|
Q1
|
Is NPEPL1 a druggable gene?
|
There are currently no approved drugs targeting NPEPL1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NPEPL1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), LAP3 (ENSG00000002549), METAP2 (ENSG00000111142), XPNPEP2 (ENSG00000122121), ERAP2 (ENSG00000164308), ERAP1 (ENSG00000164307), LVRN (ENSG00000172901), AOPEP (ENSG00000148120), METAP1D (ENSG00000172878), NPEPL1 (ENSG00000215440), RNPEPL1 (ENSG00000142327), XPNPEP3 (ENSG00000196236)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.479
|
Q1
|
Is FOLR1 a druggable gene?
|
There are currently no approved drugs targeting FOLR1, but there are 4 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FOLR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5727', 'drugName': 'Mirvetuximab Soravtansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'FOLR1 (ENSG00000110195), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5728', 'drugName': 'Mirvetuximab Soravtansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'FOLR1 (ENSG00000110195), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_739', 'drugName': 'Farletuzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FOLR1 (ENSG00000110195)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_53', 'drugName': 'Vintafolide', 'drugIsApproved': False, 'newLinkedTargets_string': 'FOLR1 (ENSG00000110195)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_825', 'drugName': 'Mirvetuximab', 'drugIsApproved': False, 'newLinkedTargets_string': 'FOLR1 (ENSG00000110195)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1201
|
Q1
|
Is PTK2 a druggable gene?
|
There are currently no approved drugs targeting PTK2, but there are 7 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PTK2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3099', 'drugName': 'Defactinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2B (ENSG00000120899), PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6171', 'drugName': 'Gsk-2256098', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3098', 'drugName': 'Defactinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2B (ENSG00000120899), PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3030', 'drugName': 'Conteltinib ', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398), IGF1R (ENSG00000140443), PTK2B (ENSG00000120899)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5608', 'drugName': 'Vs-4718', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4475', 'drugName': 'Cep-37440', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3029', 'drugName': 'Conteltinib ', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398), IGF1R (ENSG00000140443), PTK2B (ENSG00000120899)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2004', 'drugName': 'Bi-853520', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3032', 'drugName': 'Conteltinib ', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398), IGF1R (ENSG00000140443), PTK2B (ENSG00000120899)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3031', 'drugName': 'Conteltinib ', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398), IGF1R (ENSG00000140443), PTK2B (ENSG00000120899)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2212', 'drugName': 'Pf-00562271', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4476', 'drugName': 'Cep-37440', 'drugIsApproved': False, 'newLinkedTargets_string': 'ALK (ENSG00000171094), PTK2 (ENSG00000169398)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.668
|
Q1
|
Is IL11RA a druggable gene?
|
There is 1 drug, Oprelvekin, that targets IL11RA, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL11RA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2215', 'drugName': 'Oprelvekin', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL11RA (ENSG00000137070)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1236
|
Q1
|
Is RPL15 a druggable gene?
|
There is 1 drug, Ataluren, that targets RPL15, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPL15 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}]
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general
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Similarity Search, Order By, Distinct
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Approval Status, Genetic Target
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Q1.449
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Q1
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Is FAU a druggable gene?
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There is 1 drug, Ataluren, that targets FAU, indicating that it is a druggable gene.
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SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FAU %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
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[{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4690', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4448', 'drugName': 'Elx-02', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4691', 'drugName': 'Mt-3724', 'drugIsApproved': False, 'newLinkedTargets_string': 'MS4A1 (ENSG00000156738), RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2146', 'drugName': 'Dorlimomab Aritox', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_437', 'drugName': 'Cycloheximide', 'drugIsApproved': False, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG00000171863), RPS8 (ENSG00000142937), RPS9 (ENSG00000170889), RPS10 (ENSG00000124614), RPS11 (ENSG00000142534), RPS12 (ENSG00000112306), RPS13 (ENSG00000110700), RPS14 (ENSG00000164587), RPS15 (ENSG00000115268), RPS15A (ENSG00000134419), RPS16 (ENSG00000105193), RPS17 (ENSG00000182774), RPS18 (ENSG00000231500), RPS19 (ENSG00000105372), RPS20 (ENSG00000008988), RPS21 (ENSG00000171858), RPS23 (ENSG00000186468), RPS24 (ENSG00000138326), RPS25 (ENSG00000118181), RPS26 (ENSG00000197728), RPS27A (ENSG00000143947), RPS28 (ENSG00000233927), RPS29 (ENSG00000213741), FAU (ENSG00000149806), RPL3 (ENSG00000100316), RPL4 (ENSG00000174444), RPL5 (ENSG00000122406), RPL6 (ENSG00000089009), RPL7 (ENSG00000147604), RPL7A (ENSG00000148303), RPL8 (ENSG00000161016), RPL9 (ENSG00000163682), RPL10 (ENSG00000147403), RPL10A (ENSG00000198755), RPL11 (ENSG00000142676), RPL12 (ENSG00000197958), RPL13 (ENSG00000167526), RPL13A (ENSG00000142541), RPL14 (ENSG00000188846), RPL15 (ENSG00000174748), RPL17 (ENSG00000265681), RPL18 (ENSG00000063177), RPL18A (ENSG00000105640), RPL19 (ENSG00000108298), RPL21 (ENSG00000122026), RPL22 (ENSG00000116251), RPL23 (ENSG00000125691), RPL23A (ENSG00000198242), RPL24 (ENSG00000114391), RPL26 (ENSG00000161970), RPL27 (ENSG00000131469), RPL27A (ENSG00000166441), RPL28 (ENSG00000108107), RPL29 (ENSG00000162244), RPL30 (ENSG00000156482), RPL31 (ENSG00000071082), RPL32 (ENSG00000144713), RPL34 (ENSG00000109475), RPL35 (ENSG00000136942), RPL35A (ENSG00000182899), RPL36 (ENSG00000130255), RPL36A (ENSG00000241343), RPL37 (ENSG00000145592), RPL37A (ENSG00000197756), RPL38 (ENSG00000172809), RPL39 (ENSG00000198918), RPL41 (ENSG00000229117), RPLP0 (ENSG00000089157), RPLP1 (ENSG00000137818)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.180
|
Q1
|
Is CASP5 a druggable gene?
|
There are currently no approved drugs targeting CASP5, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CASP5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_45', 'drugName': 'Emricasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP4 (ENSG00000196954), CASP9 (ENSG00000132906), CASP3 (ENSG00000164305), CASP5 (ENSG00000137757), CASP6 (ENSG00000138794), CASP7 (ENSG00000165806), CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP2 (ENSG00000106144), CASP10 (ENSG00000003400), CASP14 (ENSG00000105141), CASP12 (ENSG00000204403)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.392
|
Q1
|
Is EGFL7 a druggable gene?
|
There are currently no approved drugs targeting EGFL7, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EGFL7 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5915', 'drugName': 'Parsatuzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'EGFL7 (ENSG00000172889)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1322
|
Q1
|
Is RXRG a druggable gene?
|
There are currently 4 approved drugs which target RXRG, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RXRG %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5080', 'drugName': 'Acitretin', 'drugIsApproved': True, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RARG (ENSG00000172819), RXRG (ENSG00000143171), RARB (ENSG00000077092), RARA (ENSG00000131759), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_701', 'drugName': 'Alitretinoin', 'drugIsApproved': True, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RARG (ENSG00000172819), RXRG (ENSG00000143171), RARB (ENSG00000077092), RARA (ENSG00000131759), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3322', 'drugName': 'Bexarotene', 'drugIsApproved': True, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RXRG (ENSG00000143171), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_343', 'drugName': 'Etretinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RARG (ENSG00000172819), RXRG (ENSG00000143171), RARB (ENSG00000077092), RARA (ENSG00000131759), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_633', 'drugName': 'Irx-4204', 'drugIsApproved': False, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RXRG (ENSG00000143171), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6279', 'drugName': 'Mofarotene', 'drugIsApproved': False, 'newLinkedTargets_string': 'RXRB (ENSG00000204231), RARG (ENSG00000172819), RXRG (ENSG00000143171), RARB (ENSG00000077092), RARA (ENSG00000131759), RXRA (ENSG00000186350)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.935
|
Q1
|
Is NDUFA1 a druggable gene?
|
There are currently 2 approved drugs which target NDUFA1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFA1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1388
|
Q1
|
Is SOD1 a druggable gene?
|
There are currently no approved drugs targeting SOD1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SOD1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_651', 'drugName': 'Tofersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'SOD1 (ENSG00000142168)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.625
|
Q1
|
Is HTR3C a druggable gene?
|
There are currently 7 approved drugs which target HTR3C, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR3C %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2386', 'drugName': 'Clothiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD4 (ENSG00000069696), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3083', 'drugName': 'Tropisetron', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2388', 'drugName': 'Clothiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD4 (ENSG00000069696), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1378', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1377', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2387', 'drugName': 'Clothiapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2B (ENSG00000135914), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), DRD4 (ENSG00000069696), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3880', 'drugName': 'Dexfenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2863', 'drugName': 'Dexfenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6383', 'drugName': 'Zimeldine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_893', 'drugName': 'Zimeldine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_220', 'drugName': 'Ramosetron', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2793', 'drugName': 'Ramosetron Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4080', 'drugName': 'Mosapride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), HTR4 (ENSG00000164270)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4175', 'drugName': 'Renzapride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), HTR4 (ENSG00000164270)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4079', 'drugName': 'Mosapride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), HTR4 (ENSG00000164270)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4176', 'drugName': 'Renzapride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), HTR4 (ENSG00000164270)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_580', 'drugName': 'Pumosetrag', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4325', 'drugName': 'Rg3487', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA7 (ENSG00000175344), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3469', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3470', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3471', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3472', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2119', 'drugName': 'Rg3487', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA7 (ENSG00000175344), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3473', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3474', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3475', 'drugName': 'Tedatioxetine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC6A3 (ENSG00000142319), HTR2A (ENSG00000102468), ADRA1A (ENSG00000120907), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), SLC6A2 (ENSG00000103546), HTR2C (ENSG00000147246), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2120', 'drugName': 'Rg3487', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA7 (ENSG00000175344), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4324', 'drugName': 'Rg3487', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA7 (ENSG00000175344), HTR3A (ENSG00000166736), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.594
|
Q1
|
Is HLA-DRB4 a druggable gene?
|
There are currently no approved drugs targeting HLA-DRB4, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HLA-DRB4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_363', 'drugName': 'Apolizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'HLA-DRB3 (ENSG00000231679), HLA-DRB5 (ENSG00000198502), HLA-DRB1 (ENSG00000196126), HLA-DRB4 (ENSG00000231021)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1510
|
Q1
|
Is TXK a druggable gene?
|
There are currently no approved drugs targeting TXK, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TXK %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4380', 'drugName': 'Pf-06651600', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITK (ENSG00000113263), BMX (ENSG00000102010), TEC (ENSG00000135605), TXK (ENSG00000074966), BTK (ENSG00000010671), JAK3 (ENSG00000105639)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4381', 'drugName': 'Pf-06651600', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITK (ENSG00000113263), BMX (ENSG00000102010), TEC (ENSG00000135605), TXK (ENSG00000074966), BTK (ENSG00000010671), JAK3 (ENSG00000105639)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.893
|
Q1
|
Is MMP1 a druggable gene?
|
There are currently 4 approved drugs which target MMP1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MMP1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2398', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3046', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5151', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5152', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2399', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2401', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3045', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_288', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3047', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_286', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2397', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5149', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_287', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3048', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_289', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5150', 'drugName': 'Doxycycline Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2400', 'drugName': 'Doxycycline Hyclate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP1 (ENSG00000196611), MMP7 (ENSG00000137673), MMP8 (ENSG00000118113)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3049', 'drugName': 'Doxycycline', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP1 (ENSG00000196611), MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_285', 'drugName': 'Doxycycline Anhydrous', 'drugIsApproved': True, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5864', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5859', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5863', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5860', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5861', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5862', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_105', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_104', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_106', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_107', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_108', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_109', 'drugName': 'Rebimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP14 (ENSG00000157227), MMP13 (ENSG00000137745), MMP9 (ENSG00000100985), MMP8 (ENSG00000118113), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.814
|
Q1
|
Is LAP3 a druggable gene?
|
There are currently no approved drugs targeting LAP3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LAP3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), LAP3 (ENSG00000002549), METAP2 (ENSG00000111142), XPNPEP2 (ENSG00000122121), ERAP2 (ENSG00000164308), ERAP1 (ENSG00000164307), LVRN (ENSG00000172901), AOPEP (ENSG00000148120), METAP1D (ENSG00000172878), NPEPL1 (ENSG00000215440), RNPEPL1 (ENSG00000142327), XPNPEP3 (ENSG00000196236)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.905
|
Q1
|
Is MSLN a druggable gene?
|
There are currently no approved drugs targeting MSLN, but there are 5 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MSLN %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1866', 'drugName': 'Lmb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'MSLN (ENSG00000102854), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1867', 'drugName': 'Lmb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'MSLN (ENSG00000102854), EEF2 (ENSG00000167658)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2345', 'drugName': 'Amatuximab', 'drugIsApproved': False, 'newLinkedTargets_string': 'MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5095', 'drugName': 'Anetumab Ravtansine', 'drugIsApproved': False, 'newLinkedTargets_string': 'MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6058', 'drugName': 'Ss1(Dsfv)-Pe38', 'drugIsApproved': False, 'newLinkedTargets_string': 'MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_641', 'drugName': 'Rg-7600', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_642', 'drugName': 'Rg-7600', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), MSLN (ENSG00000102854)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1195
|
Q1
|
Is PTGFR a druggable gene?
|
There are currently 9 approved drugs which target PTGFR, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PTGFR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3870', 'drugName': 'Travoprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5593', 'drugName': 'Carboprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2928', 'drugName': 'Carboprost Tromethamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_704', 'drugName': 'Bimatoprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_318', 'drugName': 'Latanoprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1161', 'drugName': 'Dinoprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3570', 'drugName': 'Dinoprost Tromethamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2312', 'drugName': 'Latanoprostene Bunod', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4212', 'drugName': 'Tafluprost', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4095', 'drugName': 'Al-12182', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2979', 'drugName': 'Sepetaprost', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGER3 (ENSG00000050628), PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2980', 'drugName': 'Sepetaprost', 'drugIsApproved': False, 'newLinkedTargets_string': 'PTGER3 (ENSG00000050628), PTGFR (ENSG00000122420)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.296
|
Q1
|
Is COL4A1 a druggable gene?
|
There are currently 2 approved drugs which target COL4A1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL4A1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1275', 'drugName': 'Collagenase Clostridium Histolyticum', 'drugIsApproved': True, 'newLinkedTargets_string': 'COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1126
|
Q1
|
Is PRKAB1 a druggable gene?
|
There are currently no approved drugs targeting PRKAB1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRKAB1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5888', 'drugName': 'Acadesine', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKAA2 (ENSG00000162409), PRKAB2 (ENSG00000131791), PRKAG1 (ENSG00000181929), PRKAG2 (ENSG00000106617), PRKAB1 (ENSG00000111725), PRKAA1 (ENSG00000132356), PRKAG3 (ENSG00000115592)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.898
|
Q1
|
Is MMP3 a druggable gene?
|
There are currently no approved drugs targeting MMP3, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MMP3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5863', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5859', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5862', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5864', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5860', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5861', 'drugName': 'Marimastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP9 (ENSG00000100985), MMP3 (ENSG00000149968), MMP7 (ENSG00000137673), MMP1 (ENSG00000196611), MMP2 (ENSG00000087245), MMP12 (ENSG00000262406)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1944', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1945', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1946', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1947', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1948', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1949', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1950', 'drugName': 'Cts-1027', 'drugIsApproved': False, 'newLinkedTargets_string': 'MMP13 (ENSG00000137745), MMP8 (ENSG00000118113), MMP3 (ENSG00000149968), MMP2 (ENSG00000087245), MMP9 (ENSG00000100985), MMP12 (ENSG00000262406), MMP14 (ENSG00000157227)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.90
|
Q1
|
Is ATP4A a druggable gene?
|
There are currently 14 approved drugs which target ATP4A, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ATP4A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5144', 'drugName': 'Rabeprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4835', 'drugName': 'Pantoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2162', 'drugName': 'Esomeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3760', 'drugName': 'Esomeprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_908', 'drugName': 'Dexlansoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2645', 'drugName': 'Esomeprazole Strontium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5640', 'drugName': 'Vonoprazan Fumarate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5499', 'drugName': 'Vonoprazan', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1903', 'drugName': 'Pantoprazole Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4604', 'drugName': 'Omeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4440', 'drugName': 'Esomeprazole Magnesium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3572', 'drugName': 'Rabeprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3369', 'drugName': 'Omeprazole Magnesium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2720', 'drugName': 'Lansoprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3592', 'drugName': 'Abeprazan', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2643', 'drugName': 'Ilaprazole', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1354', 'drugName': 'Tegoprazan', 'drugIsApproved': False, 'newLinkedTargets_string': 'ATP4A (ENSG00000105675), ATP4B (ENSG00000186009)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1007
|
Q1
|
Is NR1H4 a druggable gene?
|
There are currently 3 approved drugs which target NR1H4, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NR1H4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4210', 'drugName': 'Ursodiol', 'drugIsApproved': True, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3863', 'drugName': 'Obeticholic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_976', 'drugName': 'Chenodiol', 'drugIsApproved': True, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5522', 'drugName': 'Cilofexor', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_302', 'drugName': 'Tern-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2711', 'drugName': 'Px-102', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5905', 'drugName': 'Nidufexor', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3019', 'drugName': 'Tropifexor', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4186', 'drugName': 'Turofexorate Isopropyl', 'drugIsApproved': False, 'newLinkedTargets_string': 'NR1H4 (ENSG00000012504)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.990
|
Q1
|
Is NOTCH2 a druggable gene?
|
There are currently no approved drugs targeting NOTCH2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NOTCH2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4401', 'drugName': 'Tarextumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOTCH2 (ENSG00000134250), NOTCH3 (ENSG00000074181)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4402', 'drugName': 'Tarextumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOTCH2 (ENSG00000134250), NOTCH3 (ENSG00000074181)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1427
|
Q1
|
Is TGFBR1 a druggable gene?
|
There are currently no approved drugs targeting TGFBR1, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TGFBR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_166', 'drugName': 'Vactosertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFBR1 (ENSG00000106799)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_818', 'drugName': 'Galunisertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFBR1 (ENSG00000106799)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.683
|
Q1
|
Is IL1B a druggable gene?
|
There are currently 2 approved drugs which target IL1B, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL1B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5122', 'drugName': 'Canakinumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3681', 'drugName': 'Rilonacept', 'drugIsApproved': True, 'newLinkedTargets_string': 'IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4946', 'drugName': 'Gevokizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_574', 'drugName': 'Lutikizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1A (ENSG00000115008), IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_573', 'drugName': 'Lutikizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1A (ENSG00000115008), IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2894', 'drugName': 'Cdp-484', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL1B (ENSG00000125538)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1423
|
Q1
|
Is TGFA a druggable gene?
|
There are currently no approved drugs targeting TGFA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TGFA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_509', 'drugName': 'Fepixnebart', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFA (ENSG00000163235), EREG (ENSG00000124882)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_510', 'drugName': 'Fepixnebart', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFA (ENSG00000163235), EREG (ENSG00000124882)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.720
|
Q1
|
Is ITGAM a druggable gene?
|
There are currently no approved drugs targeting ITGAM, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ITGAM %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_553', 'drugName': 'Rovelizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB2 (ENSG00000160255), ITGAM (ENSG00000169896), ITGAL (ENSG00000005844)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_554', 'drugName': 'Rovelizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ITGB2 (ENSG00000160255), ITGAM (ENSG00000169896), ITGAL (ENSG00000005844)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.973
|
Q1
|
Is NDUFS7 a druggable gene?
|
There are currently 2 approved drugs which target NDUFS7, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFS7 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.292
|
Q1
|
Is COL27A1 a druggable gene?
|
There are currently 2 approved drugs which target COL27A1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL27A1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1275', 'drugName': 'Collagenase Clostridium Histolyticum', 'drugIsApproved': True, 'newLinkedTargets_string': 'COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1454
|
Q1
|
Is TNFSF12 a druggable gene?
|
There are currently no approved drugs targeting TNFSF12, but there are 2 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNFSF12 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1562', 'drugName': 'Biib-023', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFSF12 (ENSG00000239697)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5094', 'drugName': 'Ro-5458640', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFSF12 (ENSG00000239697)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.615
|
Q1
|
Is HTR1A a druggable gene?
|
There are currently 19 approved drugs which target HTR1A, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4681', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2808', 'drugName': 'Methysergide Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2863', 'drugName': 'Dexfenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5850', 'drugName': 'Vilazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_541', 'drugName': 'Buspirone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1378', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5196', 'drugName': 'Vilazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5197', 'drugName': 'Vilazodone', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2621', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_776', 'drugName': 'Vortioxetine Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2172', 'drugName': 'Vortioxetine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3522', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1377', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3716', 'drugName': 'Methysergide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2620', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5212', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5211', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4302', 'drugName': 'Buspirone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_893', 'drugName': 'Zimeldine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2806', 'drugName': 'Methysergide Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5213', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2171', 'drugName': 'Vortioxetine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3717', 'drugName': 'Methysergide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2807', 'drugName': 'Methysergide Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4846', 'drugName': 'Alverine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), HNF4A (ENSG00000101076)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_777', 'drugName': 'Vortioxetine Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4680', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5851', 'drugName': 'Vilazodone Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6348', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6350', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6349', 'drugName': 'Brexpiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2A (ENSG00000102468), DRD2 (ENSG00000149295), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2619', 'drugName': 'Aripiprazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6383', 'drugName': 'Zimeldine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3880', 'drugName': 'Dexfenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3520', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3521', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2170', 'drugName': 'Vortioxetine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_778', 'drugName': 'Vortioxetine Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3519', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4847', 'drugName': 'Alverine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), HNF4A (ENSG00000101076)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3715', 'drugName': 'Methysergide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR2B (ENSG00000135914), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4679', 'drugName': 'Aripiprazole Lauroxil', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), HTR2A (ENSG00000102468), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5214', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3447', 'drugName': 'Ulotaront', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), TAAR1 (ENSG00000146399)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3446', 'drugName': 'Ulotaront', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), TAAR1 (ENSG00000146399)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1169', 'drugName': 'Osemozotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2762', 'drugName': 'Sarizotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6152', 'drugName': 'Lecozotan Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4101', 'drugName': 'Bifeprunox', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2760', 'drugName': 'Sarizotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4760', 'drugName': 'Sarizotan Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4759', 'drugName': 'Sarizotan Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4433', 'drugName': 'Pardoprunox', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5444', 'drugName': 'Naluzotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4757', 'drugName': 'Sarizotan Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4758', 'drugName': 'Sarizotan Hydrochloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1643', 'drugName': 'Lecozotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2761', 'drugName': 'Sarizotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3684', 'drugName': 'Xaliproden', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4434', 'drugName': 'Pardoprunox', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2759', 'drugName': 'Sarizotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD4 (ENSG00000069696), HTR1A (ENSG00000178394), DRD3 (ENSG00000151577), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4102', 'drugName': 'Bifeprunox', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394), DRD2 (ENSG00000149295)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1152', 'drugName': 'Gepirone', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4838', 'drugName': 'Gsk163090', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4839', 'drugName': 'Gsk163090', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1012', 'drugName': 'Du 125530', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_84', 'drugName': 'Robalzotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_538', 'drugName': 'Befiradol', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4469', 'drugName': 'Repinotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3853', 'drugName': 'Piclozotan', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4836', 'drugName': 'Gsk163090', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4837', 'drugName': 'Gsk163090', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), SLC6A4 (ENSG00000108576)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1854', 'drugName': 'Adoprazine', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1855', 'drugName': 'Adoprazine', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1856', 'drugName': 'Adoprazine', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), HTR1A (ENSG00000178394)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.350
|
Q1
|
Is CYP3A5 a druggable gene?
|
There are currently 2 approved drugs which target CYP3A5, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CYP3A5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2751', 'drugName': 'Ritonavir', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP3A4 (ENSG00000160868), CYP3A5 (ENSG00000106258), CYP3A43 (ENSG00000021461), CYP3A7 (ENSG00000160870)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2752', 'drugName': 'Ritonavir', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP3A4 (ENSG00000160868), CYP3A5 (ENSG00000106258), CYP3A43 (ENSG00000021461), CYP3A7 (ENSG00000160870)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4493', 'drugName': 'Cobicistat', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP3A4 (ENSG00000160868), CYP3A5 (ENSG00000106258), CYP3A43 (ENSG00000021461), CYP3A7 (ENSG00000160870)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.587
|
Q1
|
Is HDAC6 a druggable gene?
|
There are currently 5 approved drugs which target HDAC6, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HDAC6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1601', 'drugName': 'Belinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2372', 'drugName': 'Vorinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC2 (ENSG00000196591), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4906', 'drugName': 'Panobinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5237', 'drugName': 'Panobinostat Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2373', 'drugName': 'Vorinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC2 (ENSG00000196591), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6063', 'drugName': 'Romidepsin', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2374', 'drugName': 'Vorinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC2 (ENSG00000196591), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2375', 'drugName': 'Vorinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC2 (ENSG00000196591), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_296', 'drugName': 'Abexinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5058', 'drugName': 'Entinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_685', 'drugName': 'Tacedinaline', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_129', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_130', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6353', 'drugName': 'Ricolinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC6 (ENSG00000094631)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_127', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_128', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3735', 'drugName': 'Quisinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5661', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5663', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5662', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1518
|
Q1
|
Is UBA3 a druggable gene?
|
There are currently no approved drugs targeting UBA3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%UBA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3764', 'drugName': 'Pevonedistat', 'drugIsApproved': False, 'newLinkedTargets_string': 'UBA3 (ENSG00000144744), NAE1 (ENSG00000159593)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1358
|
Q1
|
Is SLAMF7 a druggable gene?
|
There is 1 drug, Elotuzumab, that targets SLAMF7, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SLAMF7 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5815', 'drugName': 'Elotuzumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLAMF7 (ENSG00000026751)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1646', 'drugName': 'Azintuxizumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), SLAMF7 (ENSG00000026751)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_1647', 'drugName': 'Azintuxizumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBA1B (ENSG00000123416), TUBA1C (ENSG00000167553), TUBA3E (ENSG00000152086), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB6 (ENSG00000176014), SLAMF7 (ENSG00000026751)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1379
|
Q1
|
Is SLC9A3 a druggable gene?
|
There are currently 2 approved drugs which target SLC9A3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SLC9A3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4791', 'drugName': 'Tenapanor', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC9A3 (ENSG00000066230)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3816', 'drugName': 'Tenapanor Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SLC9A3 (ENSG00000066230)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2483', 'drugName': 'Squalamine', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC9A3 (ENSG00000066230)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6329', 'drugName': 'Squalamine Lactate', 'drugIsApproved': False, 'newLinkedTargets_string': 'SLC9A3 (ENSG00000066230)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.619
|
Q1
|
Is HTR1F a druggable gene?
|
There are currently 11 approved drugs which target HTR1F, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR1F %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2456', 'drugName': 'Eletriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3458', 'drugName': 'Almotriptan Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3459', 'drugName': 'Almotriptan Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3460', 'drugName': 'Almotriptan Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3981', 'drugName': 'Eletriptan Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3982', 'drugName': 'Eletriptan Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2863', 'drugName': 'Dexfenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3880', 'drugName': 'Dexfenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6383', 'drugName': 'Zimeldine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1377', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1378', 'drugName': 'Amisulpride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2458', 'drugName': 'Eletriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2781', 'drugName': 'Almotriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1894', 'drugName': 'Lasmiditan Succinate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4144', 'drugName': 'Lasmiditan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_893', 'drugName': 'Zimeldine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), HTR2C (ENSG00000147246), HTR1E (ENSG00000168830), HTR7 (ENSG00000148680), HTR6 (ENSG00000158748), HTR5A (ENSG00000157219), HTR3E (ENSG00000186038), HTR3B (ENSG00000149305), HTR3D (ENSG00000186090), HTR3C (ENSG00000178084)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3980', 'drugName': 'Eletriptan Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2457', 'drugName': 'Eletriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2782', 'drugName': 'Almotriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2780', 'drugName': 'Almotriptan', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR1D (ENSG00000179546), HTR1B (ENSG00000135312)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.460
|
Q1
|
Is FGB a druggable gene?
|
There is 1 drug, Fibrinolysin, Human, that targets FGB, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FGB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1199', 'drugName': 'Fibrinolysin, Human', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGA (ENSG00000171560), FGB (ENSG00000171564), FGG (ENSG00000171557)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5760', 'drugName': 'Fibrinogen, Human', 'drugIsApproved': False, 'newLinkedTargets_string': 'FGA (ENSG00000171560), FGB (ENSG00000171564), FGG (ENSG00000171557)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1397', 'drugName': 'Ancrod', 'drugIsApproved': False, 'newLinkedTargets_string': 'FGA (ENSG00000171560), FGB (ENSG00000171564), FGG (ENSG00000171557)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3582', 'drugName': 'Alfimeprase', 'drugIsApproved': False, 'newLinkedTargets_string': 'FGA (ENSG00000171560), FGB (ENSG00000171564), FGG (ENSG00000171557)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6221', 'drugName': 'Plasminogen', 'drugIsApproved': False, 'newLinkedTargets_string': 'FGA (ENSG00000171560), FGB (ENSG00000171564), FGG (ENSG00000171557)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5505', 'drugName': 'Biciromab Brallobarbital', 'drugIsApproved': False, 'newLinkedTargets_string': 'FGB (ENSG00000171564)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.377
|
Q1
|
Is DRD5 a druggable gene?
|
There are currently 6 approved drugs which target DRD5, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DRD5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3173', 'drugName': 'Pimozide', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2378', 'drugName': 'Amoxapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3519', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3520', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3522', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5211', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5212', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5214', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5213', 'drugName': 'Ergoloid', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2377', 'drugName': 'Amoxapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6076', 'drugName': 'Pergolide Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2376', 'drugName': 'Amoxapine', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845), SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3521', 'drugName': 'Ergoloid Mesylates', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1B (ENSG00000135312), HTR1A (ENSG00000178394), ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214), ADRA2B (ENSG00000274286), DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3172', 'drugName': 'Pimozide', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845), HTR2A (ENSG00000102468)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4078', 'drugName': 'Pergolide', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2056', 'drugName': 'Tavapadon', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD1 (ENSG00000184845), DRD5 (ENSG00000169676)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2057', 'drugName': 'Tavapadon', 'drugIsApproved': False, 'newLinkedTargets_string': 'DRD1 (ENSG00000184845), DRD5 (ENSG00000169676)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.335
|
Q1
|
Is CX3CL1 a druggable gene?
|
There are currently no approved drugs targeting CX3CL1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CX3CL1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_537', 'drugName': 'Quetmolimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CX3CL1 (ENSG00000006210)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.782
|
Q1
|
Is KCNS3 a druggable gene?
|
There are currently 5 approved drugs which target KCNS3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNS3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1356
|
Q1
|
Is SIGMAR1 a druggable gene?
|
There are currently 10 approved drugs which target SIGMAR1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SIGMAR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5072', 'drugName': 'Dextromethorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5996', 'drugName': 'Dextromethorphan Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3604', 'drugName': 'Dextromethorphan Polistirex', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3605', 'drugName': 'Dextromethorphan Polistirex', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_140', 'drugName': 'Fenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_141', 'drugName': 'Fenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3886', 'drugName': 'Fenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3888', 'drugName': 'Fenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3887', 'drugName': 'Fenfluramine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR2C (ENSG00000147246), HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5995', 'drugName': 'Dextromethorphan Hydrobromide', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_652', 'drugName': 'Pentazocine Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2947', 'drugName': 'Carbetapentane', 'drugIsApproved': True, 'newLinkedTargets_string': 'SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1542', 'drugName': 'Pentazocine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_139', 'drugName': 'Fenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1D (ENSG00000179546), SIGMAR1 (ENSG00000147955), HTR2C (ENSG00000147246)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5073', 'drugName': 'Dextromethorphan', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3200', 'drugName': 'Pentazocine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5379', 'drugName': 'Carbetapentane Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'SIGMAR1 (ENSG00000147955)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.735
|
Q1
|
Is KCNA2 a druggable gene?
|
There are currently 5 approved drugs which target KCNA2, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNA2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1425
|
Q1
|
Is TGFB2 a druggable gene?
|
There is 1 drug, Luspatercept, that targets TGFB2, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TGFB2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_6093', 'drugName': 'Luspatercept', 'drugIsApproved': True, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3208', 'drugName': 'Bintrafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), CD274 (ENSG00000120217)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3611', 'drugName': 'Lerdelimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_86', 'drugName': 'Trabedersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3207', 'drugName': 'Bintrafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), CD274 (ENSG00000120217)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5912', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5911', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5913', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.586
|
Q1
|
Is HDAC5 a druggable gene?
|
There are currently 4 approved drugs which target HDAC5, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HDAC5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4906', 'drugName': 'Panobinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6063', 'drugName': 'Romidepsin', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1601', 'drugName': 'Belinostat', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5237', 'drugName': 'Panobinostat Lactate', 'drugIsApproved': True, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_296', 'drugName': 'Abexinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_685', 'drugName': 'Tacedinaline', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5058', 'drugName': 'Entinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_129', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3735', 'drugName': 'Quisinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_130', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_127', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_128', 'drugName': 'Fimepinostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIK3CB (ENSG00000051382), PIK3CD (ENSG00000171608), PIK3CA (ENSG00000121879), HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5661', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5662', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5663', 'drugName': 'Cudc-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'HDAC1 (ENSG00000116478), HDAC3 (ENSG00000171720), HDAC6 (ENSG00000094631), HDAC2 (ENSG00000196591), HDAC5 (ENSG00000108840), HDAC7 (ENSG00000061273), HDAC8 (ENSG00000147099), HDAC11 (ENSG00000163517), HDAC4 (ENSG00000068024), HDAC9 (ENSG00000048052), HDAC10 (ENSG00000100429), EGFR (ENSG00000146648), ERBB2 (ENSG00000141736)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.330
|
Q1
|
Is CTNNB1 a druggable gene?
|
There are currently no approved drugs targeting CTNNB1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CTNNB1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3141', 'drugName': 'Pri-724', 'drugIsApproved': False, 'newLinkedTargets_string': 'CREBBP (ENSG00000005339), CTNNB1 (ENSG00000168036)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.320
|
Q1
|
Is CSF1R a druggable gene?
|
There are currently 6 approved drugs which target CSF1R, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CSF1R %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3920', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5659', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3449', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5655', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5656', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3923', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5653', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1793', 'drugName': 'Pexidartinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3451', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_385', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3454', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4378', 'drugName': 'Pexidartinib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), FLT3 (ENSG00000122025), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3919', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3922', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1792', 'drugName': 'Pexidartinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3918', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4377', 'drugName': 'Pexidartinib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), FLT3 (ENSG00000122025), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3453', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5660', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3450', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3452', 'drugName': 'Sunitinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5654', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3921', 'drugName': 'Sunitinib Malate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025), KIT (ENSG00000157404)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_390', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_391', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_387', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_392', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5658', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_386', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4379', 'drugName': 'Pexidartinib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), FLT3 (ENSG00000122025), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_388', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5657', 'drugName': 'Pazopanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), LCK (ENSG00000182866), FGFR1 (ENSG00000077782)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_389', 'drugName': 'Pazopanib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'FGFR1 (ENSG00000077782), FGFR3 (ENSG00000068078), KIT (ENSG00000157404), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), ITK (ENSG00000113263), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), LCK (ENSG00000182866)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1794', 'drugName': 'Pexidartinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1026', 'drugName': 'Linifanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5810', 'drugName': 'Quizartinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1028', 'drugName': 'Linifanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5215', 'drugName': 'Emactuzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1029', 'drugName': 'Linifanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1465', 'drugName': 'Vatalanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1466', 'drugName': 'Vatalanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1467', 'drugName': 'Vatalanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1468', 'drugName': 'Vatalanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1027', 'drugName': 'Linifanib', 'drugIsApproved': False, 'newLinkedTargets_string': 'FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), CSF1R (ENSG00000182578), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5806', 'drugName': 'Quizartinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5807', 'drugName': 'Quizartinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5808', 'drugName': 'Quizartinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5809', 'drugName': 'Quizartinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RET (ENSG00000165731), FLT3 (ENSG00000122025), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), KIT (ENSG00000157404), CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5430', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5429', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5433', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5432', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2114', 'drugName': 'Cabiralizumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5427', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5431', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1679', 'drugName': 'Seralutinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1680', 'drugName': 'Seralutinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5240', 'drugName': 'Arry-382', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2424', 'drugName': 'Axatilimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1681', 'drugName': 'Seralutinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), KIT (ENSG00000157404), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_477', 'drugName': 'Edicotinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5428', 'drugName': 'Enmd-2076', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), FLT3 (ENSG00000122025), FGFR3 (ENSG00000068078), AURKB (ENSG00000178999), CSF1R (ENSG00000182578), AURKA (ENSG00000087586)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5891', 'drugName': 'Imc-Cs4', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4518', 'drugName': 'Ct-1578', 'drugIsApproved': False, 'newLinkedTargets_string': 'JAK2 (ENSG00000096968), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_681', 'drugName': 'Amg-820', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5729', 'drugName': 'Plx-7486', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), NTRK2 (ENSG00000148053), NTRK1 (ENSG00000198400), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5730', 'drugName': 'Plx-7486', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), NTRK2 (ENSG00000148053), NTRK1 (ENSG00000198400), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4519', 'drugName': 'Ct-1578', 'drugIsApproved': False, 'newLinkedTargets_string': 'JAK2 (ENSG00000096968), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5731', 'drugName': 'Plx-7486', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), NTRK2 (ENSG00000148053), NTRK1 (ENSG00000198400), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_5732', 'drugName': 'Plx-7486', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), NTRK2 (ENSG00000148053), NTRK1 (ENSG00000198400), NTRK3 (ENSG00000140538)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_4520', 'drugName': 'Ct-1578', 'drugIsApproved': False, 'newLinkedTargets_string': 'JAK2 (ENSG00000096968), CSF1R (ENSG00000182578), FLT3 (ENSG00000122025)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_785', 'drugName': 'Plx-5622', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSF1R (ENSG00000182578)', 'maxClinicalTrialPhase': 1}]
|
general
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Similarity Search, Order By, Distinct
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Approval Status, Genetic Target
|
Q1.1181
|
Q1
|
Is PSMD2 a druggable gene?
|
There are currently 4 approved drugs which target PSMD2, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PSMD2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_559', 'drugName': 'Bortezomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4407', 'drugName': 'Ixazomib Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2422', 'drugName': 'Carfilzomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3334', 'drugName': 'Ixazomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_969', 'drugName': 'Oprozomib', 'drugIsApproved': False, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1 (ENSG00000129084), PSMA2 (ENSG00000106588), PSMA3 (ENSG00000100567), PSMA4 (ENSG00000041357), PSMA5 (ENSG00000143106), PSMA6 (ENSG00000100902), PSMA7 (ENSG00000101182), PSMA8 (ENSG00000154611), PSMB10 (ENSG00000205220), PSMB11 (ENSG00000222028), PSMB3 (ENSG00000277791), PSMB4 (ENSG00000159377), PSMB7 (ENSG00000136930), ADRM1 (ENSG00000130706), PSMC2 (ENSG00000161057), PSMC1 (ENSG00000100764), PSMC4 (ENSG00000013275), PSMC6 (ENSG00000100519), PSMC3 (ENSG00000165916), PSMC5 (ENSG00000087191), PSMD2 (ENSG00000175166), PSMD3 (ENSG00000108344), PSMD12 (ENSG00000197170), PSMD11 (ENSG00000108671), PSMD6 (ENSG00000163636), PSMD7 (ENSG00000103035), PSMD13 (ENSG00000185627), PSMD4 (ENSG00000159352), PSMD8 (ENSG00000099341), SEM1 (ENSG00000127922)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.982
|
Q1
|
Is NGF a druggable gene?
|
There are currently no approved drugs targeting NGF, but there are 5 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NGF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5018', 'drugName': 'Fulranumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'NGF (ENSG00000134259)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3772', 'drugName': 'Tanezumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'NGF (ENSG00000134259)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3094', 'drugName': 'Fasinumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'NGF (ENSG00000134259)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3953', 'drugName': 'Medi-578', 'drugIsApproved': False, 'newLinkedTargets_string': 'NGF (ENSG00000134259)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_6156', 'drugName': 'Pg-110', 'drugIsApproved': False, 'newLinkedTargets_string': 'NGF (ENSG00000134259)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.13
|
Q1
|
Is ACLY a druggable gene?
|
There is 1 drug, Bempedoic Acid, that targets ACLY, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ACLY %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5953', 'drugName': 'Bempedoic Acid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACLY (ENSG00000131473)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.173
|
Q1
|
Is CASP1 a druggable gene?
|
There are currently no approved drugs targeting CASP1, but there are 3 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CASP1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1849', 'drugName': 'Nivocasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP9 (ENSG00000132906)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5967', 'drugName': 'Belnacasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP1 (ENSG00000137752)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1847', 'drugName': 'Nivocasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP9 (ENSG00000132906)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_45', 'drugName': 'Emricasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP4 (ENSG00000196954), CASP9 (ENSG00000132906), CASP3 (ENSG00000164305), CASP5 (ENSG00000137757), CASP6 (ENSG00000138794), CASP7 (ENSG00000165806), CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP2 (ENSG00000106144), CASP10 (ENSG00000003400), CASP14 (ENSG00000105141), CASP12 (ENSG00000204403)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1848', 'drugName': 'Nivocasan', 'drugIsApproved': False, 'newLinkedTargets_string': 'CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP9 (ENSG00000132906)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.262
|
Q1
|
Is CHRM4 a druggable gene?
|
There are currently 2 approved drugs which target CHRM4, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CHRM4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_311', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6291', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6292', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_310', 'drugName': 'Terodiline Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (ENSG00000148408), CACNA1G (ENSG00000006283), CACNA2D4 (ENSG00000151062), CACNA1I (ENSG00000100346), CACNA1F (ENSG00000102001), CACNA1E (ENSG00000198216), CACNB4 (ENSG00000182389), CACNB2 (ENSG00000165995), CACNB1 (ENSG00000067191), CACNB3 (ENSG00000167535), CACNG7 (ENSG00000105605), CACNG5 (ENSG00000075429), CACNG2 (ENSG00000166862), CACNG4 (ENSG00000075461), CACNG8 (ENSG00000142408), CACNG3 (ENSG00000006116), CACNG6 (ENSG00000130433), CACNG1 (ENSG00000108878)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4624', 'drugName': 'Sofpironium', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5796', 'drugName': 'Sofpironium Bromide', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3335', 'drugName': 'Xanomeline', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM4 (ENSG00000180720)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3336', 'drugName': 'Xanomeline', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539), CHRM4 (ENSG00000180720)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2791', 'drugName': 'Darotropium', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5917', 'drugName': 'Darotropium Bromide', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3101', 'drugName': 'Afacifenacin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), SCN11A (ENSG00000168356), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3102', 'drugName': 'Afacifenacin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), SCN11A (ENSG00000168356), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3100', 'drugName': 'Afacifenacin', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), SCN11A (ENSG00000168356), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.996
|
Q1
|
Is NPEPPS a druggable gene?
|
There are currently no approved drugs targeting NPEPPS, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NPEPPS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), LAP3 (ENSG00000002549), METAP2 (ENSG00000111142), XPNPEP2 (ENSG00000122121), ERAP2 (ENSG00000164308), ERAP1 (ENSG00000164307), LVRN (ENSG00000172901), AOPEP (ENSG00000148120), METAP1D (ENSG00000172878), NPEPL1 (ENSG00000215440), RNPEPL1 (ENSG00000142327), XPNPEP3 (ENSG00000196236)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1148
|
Q1
|
Is PSEN1 a druggable gene?
|
There are currently no approved drugs targeting PSEN1, but there are 6 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PSEN1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5562', 'drugName': 'Nirogacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2667', 'drugName': 'Tarenflurbil', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6335', 'drugName': 'Semagacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5781', 'drugName': 'Avagacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5217', 'drugName': 'Rg-4733', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_6270', 'drugName': 'Begacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.823
|
Q1
|
Is LINGO1 a druggable gene?
|
There are currently no approved drugs targeting LINGO1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LINGO1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2176', 'drugName': 'Opicinumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'LINGO1 (ENSG00000169783)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.140
|
Q1
|
Is CA7 a druggable gene?
|
There are currently 3 approved drugs which target CA7, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CA7 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3089', 'drugName': 'Ethoxzolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5021', 'drugName': 'Methazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5020', 'drugName': 'Methazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5023', 'drugName': 'Methazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6095', 'drugName': 'Sulthiame', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5022', 'drugName': 'Methazolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA1 (ENSG00000133742), CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA4 (ENSG00000167434)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.552
|
Q1
|
Is GRIN2D a druggable gene?
|
There are currently 14 approved drugs which target GRIN2D, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GRIN2D %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_6209', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4206', 'drugName': 'Amantadine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4606', 'drugName': 'Memantine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4307', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1046', 'drugName': 'Acamprosate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_164', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4305', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6210', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4482', 'drugName': 'Esketamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_817', 'drugName': 'Esketamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1047', 'drugName': 'Acamprosate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6212', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4207', 'drugName': 'Amantadine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1959', 'drugName': 'Ketamine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_69', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_70', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_758', 'drugName': 'Felbamate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_68', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_768', 'drugName': 'Amantadine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_163', 'drugName': 'Acamprosate Calcium', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755), GABRD (ENSG00000187730), GABRG1 (ENSG00000163285), GABRB1 (ENSG00000163288), GABRE (ENSG00000102287), GABRA2 (ENSG00000151834), GABRA5 (ENSG00000186297), GABRA6 (ENSG00000145863), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_67', 'drugName': 'Orphenadrine', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2817', 'drugName': 'Memantine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_769', 'drugName': 'Amantadine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4306', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4308', 'drugName': 'Orphenadrine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6211', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG00000196639), SLC6A2 (ENSG00000103546), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2915', 'drugName': 'Ketamine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_741', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_742', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_743', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5793', 'drugName': 'Neramexane Mesylate', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5794', 'drugName': 'Neramexane Mesylate', 'drugIsApproved': False, 'newLinkedTargets_string': 'CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3009', 'drugName': 'Rapastinel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_744', 'drugName': 'Ralfinamide', 'drugIsApproved': False, 'newLinkedTargets_string': 'MAOB (ENSG00000069535), CACNA1B (ENSG00000148408), GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3404', 'drugName': 'Neramexane', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3405', 'drugName': 'Neramexane', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), CHRNA9 (ENSG00000174343), CHRNA10 (ENSG00000129749)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2523', 'drugName': 'Gw468816', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3366', 'drugName': 'Neboglamine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_2572', 'drugName': 'Perzinfotel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1129', 'drugName': 'Indantadol', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), MAOA (ENSG00000189221)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5926', 'drugName': 'Lanicemine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4732', 'drugName': 'Av-101', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1128', 'drugName': 'Indantadol', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), MAOA (ENSG00000189221)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5517', 'drugName': 'Apimostinel', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3819', 'drugName': 'Azd8108', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2181', 'drugName': 'Cns-5161', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': -1}, {'UUID': 'DrugGeneTargets_v2_5026', 'drugName': 'Delucemine', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.633
|
Q1
|
Is ICAM1 a druggable gene?
|
There are currently no approved drugs targeting ICAM1, but there are 5 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ICAM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2026', 'drugName': 'Alicaforsen', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICAM1 (ENSG00000090339)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5504', 'drugName': 'Enlimomab Pegol', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICAM1 (ENSG00000090339)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_1999', 'drugName': 'Bi-505', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICAM1 (ENSG00000090339)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4244', 'drugName': 'Enlimomab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICAM1 (ENSG00000090339)', 'maxClinicalTrialPhase': -1}, {'UUID': 'DrugGeneTargets_v2_1636', 'drugName': 'Alicaforsen Sodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICAM1 (ENSG00000090339)', 'maxClinicalTrialPhase': -1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.873
|
Q1
|
Is MC4R a druggable gene?
|
There are currently 4 approved drugs which target MC4R, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MC4R %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2878', 'drugName': 'Setmelanotide Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4990', 'drugName': 'Bremelanotide', 'drugIsApproved': True, 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_177', 'drugName': 'Bremelanotide Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_689', 'drugName': 'Setmelanotide', 'drugIsApproved': True, 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_668', 'drugName': 'Pf-00446687', 'drugIsApproved': False, 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.804
|
Q1
|
Is LAMA3 a druggable gene?
|
There is 1 drug, Ocriplasmin, that targets LAMA3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LAMA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.561
|
Q1
|
Is GSR a druggable gene?
|
There are currently 2 approved drugs which target GSR, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GSR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_4261', 'drugName': 'Carmustine', 'drugIsApproved': True, 'newLinkedTargets_string': 'GSR (ENSG00000104687)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4895', 'drugName': 'Oxiglutatione', 'drugIsApproved': True, 'newLinkedTargets_string': 'GSR (ENSG00000104687)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.141
|
Q1
|
Is CA9 a druggable gene?
|
There are currently 2 approved drugs which target CA9, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CA9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_6095', 'drugName': 'Sulthiame', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3089', 'drugName': 'Ethoxzolamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CA2 (ENSG00000104267), CA7 (ENSG00000168748), CA1 (ENSG00000133742), CA3 (ENSG00000164879), CA6 (ENSG00000131686), CA12 (ENSG00000074410), CA14 (ENSG00000118298), CA9 (ENSG00000107159), CA4 (ENSG00000167434), CA13 (ENSG00000185015), CA5B (ENSG00000169239), CA5A (ENSG00000174990)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5146', 'drugName': 'Girentuximab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CA9 (ENSG00000107159)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3902', 'drugName': 'Cg250 111In', 'drugIsApproved': False, 'newLinkedTargets_string': 'CA9 (ENSG00000107159)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4808', 'drugName': 'Iodine I 124 Girentuximab', 'drugIsApproved': False, 'newLinkedTargets_string': 'CA9 (ENSG00000107159)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6064', 'drugName': 'Cg250 177Lu', 'drugIsApproved': False, 'newLinkedTargets_string': 'CA9 (ENSG00000107159)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1342
|
Q1
|
Is SCNN1G a druggable gene?
|
There are currently 3 approved drugs which target SCNN1G, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SCNN1G %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_2590', 'drugName': 'Amiloride Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4230', 'drugName': 'Triamterene', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3975', 'drugName': 'Amiloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1778', 'drugName': 'Cofirasersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'SCNN1G (ENSG00000166828), SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4187', 'drugName': 'Idrevloride', 'drugIsApproved': False, 'newLinkedTargets_string': 'SCNN1A (ENSG00000111319), SCNN1B (ENSG00000168447), SCNN1G (ENSG00000166828)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1085
|
Q1
|
Is PIM2 a druggable gene?
|
There are currently no approved drugs targeting PIM2, but there are 3 drugs in clinical trials indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PIM2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_295', 'drugName': 'Sgi-1776', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIM1 (ENSG00000137193), PIM2 (ENSG00000102096), PIM3 (ENSG00000198355)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3068', 'drugName': 'Azd-1208', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIM1 (ENSG00000137193), PIM2 (ENSG00000102096), PIM3 (ENSG00000198355)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3198', 'drugName': 'Lgh-447', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIM1 (ENSG00000137193), PIM2 (ENSG00000102096), PIM3 (ENSG00000198355)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.226
|
Q1
|
Is CD86 a druggable gene?
|
There are currently 2 approved drugs which target CD86, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CD86 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_3639', 'drugName': 'Abatacept', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD80 (ENSG00000121594), CD86 (ENSG00000114013)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3638', 'drugName': 'Abatacept', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD80 (ENSG00000121594), CD86 (ENSG00000114013)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4094', 'drugName': 'Belatacept', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD80 (ENSG00000121594), CD86 (ENSG00000114013)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4093', 'drugName': 'Belatacept', 'drugIsApproved': True, 'newLinkedTargets_string': 'CD80 (ENSG00000121594), CD86 (ENSG00000114013)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.811
|
Q1
|
Is LAMC1 a druggable gene?
|
There is 1 drug, Ocriplasmin, that targets LAMC1, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LAMC1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.411
|
Q1
|
Is EPHA4 a druggable gene?
|
There is 1 drug, Vandetanib, that targets EPHA4, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHA4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1936', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1934', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1932', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1931', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1937', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1935', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1933', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (ENSG00000116106), EPHA8 (ENSG00000070886), EPHA6 (ENSG00000080224), EPHA7 (ENSG00000135333), EPHB3 (ENSG00000182580), EPHA3 (ENSG00000044524), EPHB1 (ENSG00000154928), EPHB4 (ENSG00000196411), EPHA1 (ENSG00000146904), EPHB6 (ENSG00000106123), EPHA10 (ENSG00000183317), SRC (ENSG00000197122), RET (ENSG00000165731), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), PTK6 (ENSG00000101213)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.327
|
Q1
|
Is CTAG1A a druggable gene?
|
There are currently no approved drugs targeting CTAG1A, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CTAG1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5339', 'drugName': 'Rasdegafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'LY75 (ENSG00000054219), CTAG1B (ENSG00000184033), CTAG1A (ENSG00000268651)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5340', 'drugName': 'Rasdegafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'LY75 (ENSG00000054219), CTAG1B (ENSG00000184033), CTAG1A (ENSG00000268651)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.301
|
Q1
|
Is COL4A6 a druggable gene?
|
There are currently 2 approved drugs which target COL4A6, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL4A6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1275', 'drugName': 'Collagenase Clostridium Histolyticum', 'drugIsApproved': True, 'newLinkedTargets_string': 'COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5820', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG00000060718), COL15A1 (ENSG00000204291), COL18A1 (ENSG00000182871), COL24A1 (ENSG00000171502), COL27A1 (ENSG00000196739), COL28A1 (ENSG00000215018), COL4A2 (ENSG00000134871), COL5A2 (ENSG00000204262), COL6A2 (ENSG00000142173), COL11A2 (ENSG00000204248), COL4A3 (ENSG00000169031), COL5A3 (ENSG00000080573), COL6A3 (ENSG00000163359), COL4A4 (ENSG00000081052), COL4A5 (ENSG00000188153), COL6A5 (ENSG00000172752), COL4A6 (ENSG00000197565), COL6A6 (ENSG00000206384), LAMA1 (ENSG00000101680), LAMA2 (ENSG00000196569), LAMA3 (ENSG00000053747), LAMA4 (ENSG00000112769), LAMA5 (ENSG00000130702), LAMB1 (ENSG00000091136), LAMB2 (ENSG00000172037), LAMB3 (ENSG00000196878), LAMB4 (ENSG00000091128), LAMC1 (ENSG00000135862), LAMC2 (ENSG00000058085), LAMC3 (ENSG00000050555)', 'maxClinicalTrialPhase': 4}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.913
|
Q1
|
Is MT-ND5 a druggable gene?
|
There are currently 2 approved drugs which target MT-ND5, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MT-ND5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.762
|
Q1
|
Is KCNH8 a druggable gene?
|
There are currently 5 approved drugs which target KCNH8, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNH8 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2190', 'drugName': 'Guanidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5420', 'drugName': 'Amifampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1734', 'drugName': 'Dalfampridine', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3435', 'drugName': 'Amifampridine Phosphate', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5027', 'drugName': 'Tedisamil', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3950', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3951', 'drugName': 'Nerispirdine', 'drugIsApproved': False, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG00000104848), KCNQ5 (ENSG00000185760), KCNQ4 (ENSG00000117013), KCNH1 (ENSG00000143473), KCNA4 (ENSG00000182255), KCNA5 (ENSG00000130037), KCNA3 (ENSG00000177272), KCNA6 (ENSG00000151079), KCNC1 (ENSG00000129159), KCND2 (ENSG00000184408), KCNB2 (ENSG00000182674), KCNC4 (ENSG00000116396), KCNC3 (ENSG00000131398), KCNB1 (ENSG00000158445), KCNA10 (ENSG00000143105), KCNV1 (ENSG00000164794), KCNH5 (ENSG00000140015), KCNG3 (ENSG00000171126), KCNG4 (ENSG00000168418), KCNV2 (ENSG00000168263), KCNS1 (ENSG00000124134), KCNH8 (ENSG00000183960), KCNC2 (ENSG00000166006), KCNS3 (ENSG00000170745), KCNH6 (ENSG00000173826), KCNF1 (ENSG00000162975), KCNH7 (ENSG00000184611), KCND1 (ENSG00000102057), KCNG1 (ENSG00000026559), KCNG2 (ENSG00000178342), KCNH3 (ENSG00000135519), KCNS2 (ENSG00000156486), KCNH4 (ENSG00000089558), SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A (ENSG00000196876), SCN10A (ENSG00000185313)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1316
|
Q1
|
Is RSPO3 a druggable gene?
|
There are currently no approved drugs targeting RSPO3, but there is 1 drug in a clinical trial indicating that it may be a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RSPO3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_5619', 'drugName': 'Rosmantuzumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'RSPO3 (ENSG00000146374), LGR4 (ENSG00000205213)', 'maxClinicalTrialPhase': 3}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.1426
|
Q1
|
Is TGFB3 a druggable gene?
|
There is 1 drug, Luspatercept, that targets TGFB3, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TGFB3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_6093', 'drugName': 'Luspatercept', 'drugIsApproved': True, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3207', 'drugName': 'Bintrafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), CD274 (ENSG00000120217)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3208', 'drugName': 'Bintrafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB1 (ENSG00000105329), TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), CD274 (ENSG00000120217)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5911', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5912', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5913', 'drugName': 'Fresolimumab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TGFB2 (ENSG00000092969), TGFB3 (ENSG00000119699), TGFB1 (ENSG00000105329)', 'maxClinicalTrialPhase': 2}]
|
general
|
Similarity Search, Order By, Distinct
|
Approval Status, Genetic Target
|
Q1.976
|
Q1
|
Is NDUFV2 a druggable gene?
|
There are currently 2 approved drugs which target NDUFV2, indicating that it is a druggable gene.
|
SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `card-ai-389220.bio_sql_benchmark.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFV2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
|
[{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1887', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1886', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1885', 'drugName': 'Metformin', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3900', 'drugName': 'Me-344', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_2970', 'drugName': 'Nv-128', 'drugIsApproved': False, 'newLinkedTargets_string': 'MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (ENSG00000165264), NDUFA4 (ENSG00000189043), NDUFA11 (ENSG00000174886), NDUFB7 (ENSG00000099795), MT-ND2 (ENSG00000198763), NDUFS2 (ENSG00000158864), MT-ND5 (ENSG00000198786), NDUFA8 (ENSG00000119421), NDUFB5 (ENSG00000136521), MT-ND4 (ENSG00000198886), MT-ND3 (ENSG00000198840), NDUFAB1 (ENSG00000004779), NDUFA1 (ENSG00000125356), NDUFS4 (ENSG00000164258), NDUFB3 (ENSG00000119013), NDUFC1 (ENSG00000109390), NDUFA2 (ENSG00000131495), NDUFS5 (ENSG00000168653), NDUFS7 (ENSG00000115286), NDUFS6 (ENSG00000145494), NDUFB1 (ENSG00000183648), NDUFS3 (ENSG00000213619), NDUFA3 (ENSG00000170906), NDUFB4 (ENSG00000065518), NDUFB8 (ENSG00000166136), NDUFB2 (ENSG00000090266), NDUFA7 (ENSG00000267855), NDUFC2 (ENSG00000151366), NDUFB10 (ENSG00000140990), NDUFV2 (ENSG00000178127), NDUFS1 (ENSG00000023228), NDUFV1 (ENSG00000167792), NDUFV3 (ENSG00000160194), NDUFA5 (ENSG00000128609), NDUFA9 (ENSG00000139180), NDUFAF2 (ENSG00000164182), NDUFAF3 (ENSG00000178057), NDUFA4L2 (ENSG00000185633), NDUFB11 (ENSG00000147123), NDUFAF4 (ENSG00000123545), NDUFA13 (ENSG00000186010), NDUFA12 (ENSG00000184752), NDUFAF1 (ENSG00000137806), NDUFB9 (ENSG00000147684)', 'maxClinicalTrialPhase': 1}]
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