pytorch safetensors medical summarization en license:apache-2.0 region:us
---
language:
- en
license: apache-2.0
pipeline_tag: summarization
tags:
- medical
widget:
- text: 'the need for magnetic resonance imaging ( mri ) in patients with an implanted
    pacemaker or implantable cardioverter - defibrillator ( icd ) is a growing clinical
    issue . it is estimated that as many as 75% of active cardiac device recipients
    will become indicated for mri . currently , the vast majority of such devices
    are contraindicated for use with an mri . in european heart rhythm association
    survey , published recently for non - mri - certified icds ( 0.51.5 t field strength
    ) , the totally subcutaneous icd ( s - icd ) system , an implantable defibrillator
    with no leads that touch the heart , has recently been demonstrated to be a safe
    and effective defibrillator option for patients at risk for sudden cardiac death
    . it provides shock therapy and post - shock pacing therapy , but no long - term
    bradycardia pacing . although it has been shown as an alternative to the standard
    transvenous icd , its compatibility with mri remains unclear . various types of
    clinical mri systems currently use a superconductive magnet that creates a static
    magnetic field strength , typically 1.5 or 3 t. the use of mri with most pacemakers
    and icds is considered a contraindication due to potential hazards , including
    heating of the electrode that resides in or on the heart , damage to myocardium
    , elevation of pacing thresholds , unintended induction of ventricular tachycardia
    ( vt ) or ventricular fibrillation ( vf ) , pacing inhibition , permanent device
    malfunction , and distortion of the mri scan . recently , mr - conditional. mr
    - conditional indicates a lack of known hazards in a specified mri environment
    with specified conditions of use . due to the variety of mri scanners and scanning
    protocols , it is not practical to test even a single device under all conditions
    . hence , mr - conditional labelling dictates that the device is safe for use
    under certain scanning conditions , as well as how the cardiac device should be
    programmed before an exposure to the magnetic field in a mri scanner . the literature
    , although limited , provides some guidance for imaging patients with implanted
    pacemakers or icds that do not have mr - conditional labelling . this single -
    centre prospective non - controlled study describes the first use of mri in patients
    with an implanted s - icd . patients with implanted s - icd systems ( boston scientific
    sqrx model 1010 and q - trak model 3010 ) were enrolled for mri testing over a
    period of 18 months . the s - icd system implanted in this patient cohort was
    composed of a can implanted in a left mid - lateral pocket and a para - sternal
    subcutaneous electrode . the s - icd is currently not certified for use with an
    mri ; therefore , the ethics committee of homolka hospital , prague , czech republic
    approved our clinical study . patients with newly implanted s - icd systems (
    < 6 weeks ) were excluded , and none of the patients had any intravascular leads
    . the patients were randomized for either a cardiac , brain , cervical , or lumbar
    spinal scan . one of the subjects underwent an additional knee examination , due
    to reported chronic pain . a total of 15 patients were enrolled into this study
    ( 12 males and three females , aged 2283 years , mean 53 years . subjects in our
    cohort ( table 1 ) underwent a total of 22 mri scans between 6 june 2012 and 24
    december 2013 . in total , five brain scans , three cardiac scans , 12 lumbar
    scans , one knee , and one cervical spine scan were conducted ( table 2 ) . however
    , in one patient a minor disc protrusion was found , in other mri revealed stenosis
    of intervertebral foramen which was causing radicular pain of the nerve root l4
    and based on this examination the patient was referred to ct - navigated periradicular
    therapy . table 1summary of patient anatomical data and scan locations , along
    with noted clinical eventsidagesexbmidgef , % indication for s - icdheating0164f20.5hcmp
    / vfs85secondary preventionnone0283m30.0post - mi / smvts post - catheter ablation/35secondary
    prevention ( post - transvenous icd extraction)none0331m25.3arvc / d / smvts68secondary
    preventionin - tolerable re - scanned0458m23.6post - mi / post - cabg30primary
    preventionnone0577m25.5post - mi30primary preventionnone0663m27.0post - mi30primary
    preventionnone0768m23.7post - mi / vfs / vts60secondary prevention post - transvenous
    icd extraction / svc occlusiontolerable0822m29.4brugada sy / vfs68secondary preventionin
    - tolerable re - scanned0959m27.1dcmp / vfs / post - mitral valve surgery/60secondary
    prev./post - transvenous icd extractionnone1041f24.6arvc / d70primary preventionnone1123f21.5lqts
    / vf60secondary preventionnone1266m36.9post - mi / vf / post - cabg50secondary
    prevention / post - repeat transvenous icd extractiontolerable1348m22.9dcmp(non
    - compaction)/vfs35secondary preventionnone1470m29systolic dysfunction of lv35primary
    preventionnone1526m33brugada sy65primary preventionnonehcmp , hypertrophic cardiomyopathy
    ; smvt , sustained monomorphic ventricular tachycardia ; mi , myocardial infarction
    ; arvc , arrhythmogenic right ventricular cardiomyopathy ; cabg , coronary artery
    by - pass graft ; lqts , long qt syndrom . table 2parmeters of s - icd and patient
    sensation during individual mri scansscan # idbody partheating sensationsshock
    zone ( b.p.m.)condit . shock zone ( b.p.m.)bat % episode num.101brainnone2302101001202brainnone240220861303l
    spinein - tolerable240220831403brainnone240220831504brainnone220190691605l spinenone220210541706l
    spinenone240220681807l spinetolerable240220582908l spinein - tolerablenananana1008brainnonenananana1108l
    spinenone2302108411209heartnone2402208911310l spinenone2301807911410heartnonenananana1511heartnone2301909711612l
    spinetolerable2001709721712l spinenone2001709421813c spinenone23019010041913l
    spinenone23019010042014l spinenone2301908612115kneenone25021010012215l spinenone2502101001s
    - icd parameters acquired prior- and post - mri were without any change , therefore
    only one value is presented.indices : na , not available ; l spine , lumbar spine
    ; c spine , cervical spine . summary of patient anatomical data and scan locations
    , along with noted clinical events hcmp , hypertrophic cardiomyopathy ; smvt ,
    sustained monomorphic ventricular tachycardia ; mi , myocardial infarction ; arvc
    , arrhythmogenic right ventricular cardiomyopathy ; cabg , coronary artery by
    - pass graft ; lqts , long qt syndrom . parmeters of s - icd and patient sensation
    during individual mri scans s - icd parameters acquired prior- and post - mri
    were without any change , therefore only one value is presented . indices : na
    , not available ; l spine , lumbar spine ; c spine , cervical spine . studies
    were performed using a siemens avanto 1.5 t mri scanner ( vb17 software , quantum
    gradient coils ) . all scans were run in normal operating mode , which is limited
    to 2 w / kg whole body averaged specific absorption rate ( sar ) . clinically
    relevant mri sequences were used for evaluation ( see table 3 ) . table 3types
    of pulse sequences typically used for imaging of respective anatomical areasscan
    locationscan sequencesflairdwiflashfsehastesestirtruefispbrainxxxxheartxxxxcervical
    spinexxkneexxxxlumbar spinexxflair , fluid attenuated inversion recovery ; dwi
    , diffusion weighted imaging ; flash , fast low angle shot ; fse , fast spin echo
    ; haste , half acquisition single - shot turbo spin echo ; se , spin echo ; stir
    , short tau inversion recovery ; truefisp , true fast imaging with steady - state
    precession.fse sequence caused heating in subjects with a thermistor probe during
    lumbar spine examination ( see the text for details ) . types of pulse sequences
    typically used for imaging of respective anatomical areas flair , fluid attenuated
    inversion recovery ; dwi , diffusion weighted imaging ; flash , fast low angle
    shot ; fse , fast spin echo ; haste , half acquisition single - shot turbo spin
    echo ; se , spin echo ; stir , short tau inversion recovery ; truefisp , true
    fast imaging with steady - state precession . fse sequence caused heating in subjects
    with a thermistor probe during lumbar spine examination ( see the text for details
    ) . patients were asked to report immediately any pain , torqueing movement ,
    or heating sensation in the area of the pocket or the electrode by pressing an
    emergency bulb . furthermore , all patients were questioned immediately following
    the mri procedure to ascertain any discomfort in the vicinity of the can or electrode
    . pulse oximetry and standard lead electrocardiogram ( ecg ) if discomfort occurred
    , the patient was asked if the scan could be repeated at a later time using a
    revised scan sequence or the subject was again randomized for another anatomical
    area . since none of the components of the s - icd system are on or in the heart
    , heating near or around however , heating near the electrode or can with the
    s - icd system may still cause serious patient discomfort . therefore , along
    with education of subjects , each patient was instrumented by taping an oesophageal
    temperature probe ( beta - therm model g22k7mcd8 ) on the skin over the mid -
    lateral implant site to record any temperature excursions that might be correlated
    to patient symptoms of heating / discomfort near the pocket . to minimize the
    risk of inappropriate therapy , the s - icd system was programmed to therapy each
    s - icd system was evaluated prior to and immediately after the scan to verify
    proper functioning , including interrogation , sensing , and battery voltage .
    after the completion of the mri , long - term regular clinical follow - up and
    checking of the device were performed . patients with implanted s - icd systems
    ( boston scientific sqrx model 1010 and q - trak model 3010 ) were enrolled for
    mri testing over a period of 18 months . the s - icd system implanted in this
    patient cohort was composed of a can implanted in a left mid - lateral pocket
    and a para - sternal subcutaneous electrode . the s - icd is currently not certified
    for use with an mri ; therefore , the ethics committee of homolka hospital , prague
    , czech republic approved our clinical study . patients with newly implanted s
    - icd systems ( < 6 weeks ) were excluded , and none of the patients had any intravascular
    leads . the patients were randomized for either a cardiac , brain , cervical ,
    or lumbar spinal scan . one of the subjects underwent an additional knee examination
    , due to reported chronic pain . a total of 15 patients were enrolled into this
    study ( 12 males and three females , aged 2283 years , mean 53 years . subjects
    in our cohort ( table 1 ) underwent a total of 22 mri scans between 6 june 2012
    and 24 december 2013 . in total , five brain scans , three cardiac scans , 12
    lumbar scans , one knee , and one cervical spine scan were conducted ( table 2
    ) . however , in one patient a minor disc protrusion was found , in other mri
    revealed stenosis of intervertebral foramen which was causing radicular pain of
    the nerve root l4 and based on this examination the patient was referred to ct
    - navigated periradicular therapy . table 1summary of patient anatomical data
    and scan locations , along with noted clinical eventsidagesexbmidgef , % indication
    for s - icdheating0164f20.5hcmp / vfs85secondary preventionnone0283m30.0post -
    mi / smvts post - catheter ablation/35secondary prevention ( post - transvenous
    icd extraction)none0331m25.3arvc / d / smvts68secondary preventionin - tolerable
    re - scanned0458m23.6post - mi / post - cabg30primary preventionnone0577m25.5post
    - mi30primary preventionnone0663m27.0post - mi30primary preventionnone0768m23.7post
    - mi / vfs / vts60secondary prevention post - transvenous icd extraction / svc
    occlusiontolerable0822m29.4brugada sy / vfs68secondary preventionin - tolerable
    re - scanned0959m27.1dcmp / vfs / post - mitral valve surgery/60secondary prev./post
    - transvenous icd extractionnone1041f24.6arvc / d70primary preventionnone1123f21.5lqts
    / vf60secondary preventionnone1266m36.9post - mi / vf / post - cabg50secondary
    prevention / post - repeat transvenous icd extractiontolerable1348m22.9dcmp(non
    - compaction)/vfs35secondary preventionnone1470m29systolic dysfunction of lv35primary
    preventionnone1526m33brugada sy65primary preventionnonehcmp , hypertrophic cardiomyopathy
    ; smvt , sustained monomorphic ventricular tachycardia ; mi , myocardial infarction
    ; arvc , arrhythmogenic right ventricular cardiomyopathy ; cabg , coronary artery
    by - pass graft ; lqts , long qt syndrom . table 2parmeters of s - icd and patient
    sensation during individual mri scansscan # idbody partheating sensationsshock
    zone ( b.p.m.)condit . shock zone ( b.p.m.)bat % episode num.101brainnone2302101001202brainnone240220861303l
    spinein - tolerable240220831403brainnone240220831504brainnone220190691605l spinenone220210541706l
    spinenone240220681807l spinetolerable240220582908l spinein - tolerablenananana1008brainnonenananana1108l
    spinenone2302108411209heartnone2402208911310l spinenone2301807911410heartnonenananana1511heartnone2301909711612l
    spinetolerable2001709721712l spinenone2001709421813c spinenone23019010041913l
    spinenone23019010042014l spinenone2301908612115kneenone25021010012215l spinenone2502101001s
    - icd parameters acquired prior- and post - mri were without any change , therefore
    only one value is presented.indices : na , not available ; l spine , lumbar spine
    ; c spine , cervical spine . summary of patient anatomical data and scan locations
    , along with noted clinical events hcmp , hypertrophic cardiomyopathy ; smvt ,
    sustained monomorphic ventricular tachycardia ; mi , myocardial infarction ; arvc
    , arrhythmogenic right ventricular cardiomyopathy ; cabg , coronary artery by
    - pass graft ; lqts , long qt syndrom . parmeters of s - icd and patient sensation
    during individual mri scans s - icd parameters acquired prior- and post - mri
    were without any change , therefore only one value is presented . indices : na
    , not available ; l spine , lumbar spine ; c spine , cervical spine . studies
    were performed using a siemens avanto 1.5 t mri scanner ( vb17 software , quantum
    gradient coils ) . all scans were run in normal operating mode , which is limited
    to 2 w / kg whole body averaged specific absorption rate ( sar ) . clinically
    relevant mri sequences were used for evaluation ( see table 3 ) . table 3types
    of pulse sequences typically used for imaging of respective anatomical areasscan
    locationscan sequencesflairdwiflashfsehastesestirtruefispbrainxxxxheartxxxxcervical
    spinexxkneexxxxlumbar spinexxflair , fluid attenuated inversion recovery ; dwi
    , diffusion weighted imaging ; flash , fast low angle shot ; fse , fast spin echo
    ; haste , half acquisition single - shot turbo spin echo ; se , spin echo ; stir
    , short tau inversion recovery ; truefisp , true fast imaging with steady - state
    precession.fse sequence caused heating in subjects with a thermistor probe during
    lumbar spine examination ( see the text for details ) . types of pulse sequences
    typically used for imaging of respective anatomical areas flair , fluid attenuated
    inversion recovery ; dwi , diffusion weighted imaging ; flash , fast low angle
    shot ; fse , fast spin echo ; haste , half acquisition single - shot turbo spin
    echo ; se , spin echo ; stir , short tau inversion recovery ; truefisp , true
    fast imaging with steady - state precession . fse sequence caused heating in subjects
    with a thermistor probe during lumbar spine examination ( see the text for details
    ) . patients were asked to report immediately any pain , torqueing movement ,
    or heating sensation in the area of the pocket or the electrode by pressing an
    emergency bulb . furthermore , all patients were questioned immediately following
    the mri procedure to ascertain any discomfort in the vicinity of the can or electrode
    . pulse oximetry and standard lead electrocardiogram ( ecg ) if discomfort occurred
    , the patient was asked if the scan could be repeated at a later time using a
    revised scan sequence or the subject was again randomized for another anatomical
    area . since none of the components of the s - icd system are on or in the heart
    , heating near or around the electrode can not harm the myocardium . however ,
    heating near the electrode or can with the s - icd system may still cause serious
    patient discomfort . therefore , along with education of subjects , each patient
    was instrumented by taping an oesophageal temperature probe ( beta - therm model
    g22k7mcd8 ) on the skin over the mid - lateral implant site to record any temperature
    excursions that might be correlated to patient symptoms of heating / discomfort
    near the pocket . to minimize the risk of inappropriate therapy , the s - icd
    system was programmed to therapy each s - icd system was evaluated prior to and
    immediately after the scan to verify proper functioning , including interrogation
    , sensing , and battery voltage . after the completion of the mri , the s - icd
    system was reprogrammed to original settings . long - term regular clinical follow
    - up and checking of the device were performed . no anomalies were noted via pulse
    oximetry or ecg during the scans for any of the patients . eleven of 15 patients
    reported no sensation or pain from heating of the can , two of 15 patients reported
    feeling some heating , and two patients reported intolerable heating ( see table
    2 ) . in patients with intolerable heating , the scan was halted within seconds
    and changed to a scan of the brain , which proceeded without incident . patient
    reports of heating in the vicinity of the can occurred only during lumbar scans
    with a thermistor probe ; no such reports occurred during scans of the brain ,
    cardiac area , cervical spine , or without the probe . in two cases where heating
    in the vicinity of the can was reported by the patient , the scan sequence was
    altered to reduce the intensity of radiofrequency ( rf ) field exposure by reducing
    the turbo factor ( e.g. from 21 to 7 ) , increasing the repetition time ( e.g.
    to > 4000 ms ) , and reducing the flip angle ( e.g. from 170 to 120 ) . the target
    values were chosen arbitrarily to maintain image contrast ( flip angle ) and keep
    scan time at reasonable limits ( turbo factor and repetition time ) . less heating
    was noted by patients after these modifications to the scan parameters were made
    . 03 ) was observed to have a skin lesion , appearing to be a circular rash or
    ulcer on the surface of the skin over the can , approximately 35 mm in diameter
    . the cause of this skin anomaly is not known ; it was later noted to have fully
    healed at a follow - up 10 days after the scan . to ascertain the effect of heating
    due to the instrumented thermistor catheter , the two patients who experienced
    the heating ( examinations 9 and 16 , see table 2 ) were rescanned several weeks
    later without the thermistor catheter in place ( examinations 11 and 17 ) . first
    , modified sequence ( with even lower amount of energy deposited in the tissue
    ) was used , which caused no heating . as no sensation was reported by the subjects
    , they were asked to report even a minimal discomfort , and the lumbar scans were
    performed using the same settings that resulted in heating with the thermistor
    catheter in place in the first imaging session . the results of the rescans revealed
    that no heating was felt by the patients when the thermistor catheter was absent
    . there were no noted changes to battery voltage , ability to detect the qrs signal
    or stored diagnostic data . pacing thresholds can not be assessed by the s - icd
    system , so this was not evaluated . none of the patients reported any pulling
    or twisting of the can or pain from heating of the s - icd electrode . for scans
    of the brain , lumbar spine , knee , and cervical spine , no effect from image
    artefact was noted in the anatomical area of interest . however , for scans of
    the cardiac area , image artefact was noted to interfere with the ability to see
    parts of the left ventricle , though the right ventricle of the heart was unaffected
    and could be imaged usefully . this was due to the can and not the electrode (
    see figure 1 ) , modifications to the protocol for the lumbar spine resulted in
    a lower signal - to - noise ratio ; however , the images remain in diagnostic
    quality ( see figure 2 ) . figure 1kinetic study in four - chamber view : the
    systolic ( a and c ) and diastolic ( b and d ) images of cine sequences , four
    - chamber view . the steady - state free precession ( ssfp ) sequence ( a and
    b ) shows more artefacts . in ssfp kinetic study , an inflow of dark blood from
    the left pulmonary veins was seen . it could be caused by s - icd but also by
    metallic ring in mitral annulus . the spoiled gradient echo ( gre ) sequence (
    c and d ) is better , but an artefact at the lateral wall is obvious . figure
    2lumbar spine imaging with icd : low sar t2 fse sequence ( upper image ) compared
    with normal t2 fse in the same subject ( lower image , for the scanning parameters
    see the discussion section ) . kinetic study in four - chamber view : the systolic
    ( a and c ) and diastolic ( b and d ) images of cine sequences , four - chamber
    view . the steady - state free precession ( ssfp ) sequence ( a and b ) shows
    more artefacts . in ssfp kinetic study , an inflow of dark blood from the left
    pulmonary veins was seen . it could be caused by s - icd but also by metallic
    ring in mitral annulus . the spoiled gradient echo ( gre ) sequence ( c and d
    ) is better , but an artefact at the lateral wall is obvious . lumbar spine imaging
    with icd : low sar t2 fse sequence ( upper image ) compared with normal t2 fse
    in the same subject ( lower image , for the scanning parameters see the discussion
    section ) . there were no noted changes to battery voltage , ability to detect
    the qrs signal or stored diagnostic data . pacing thresholds can not be assessed
    by the s - icd system , so this was not evaluated . none of the patients reported
    any pulling or twisting of the can or pain from heating of the s - icd electrode
    . for scans of the brain , lumbar spine , knee , and cervical spine , no effect
    from image artefact was noted in the anatomical area of interest . however , for
    scans of the cardiac area , image artefact was noted to interfere with the ability
    to see parts of the left ventricle , though the right ventricle of the heart was
    unaffected and could be imaged usefully . this was due to the can and not the
    electrode ( see figure 1 ) , modifications to the protocol for the lumbar spine
    resulted in a lower signal - to - noise ratio ; however , the images remain in
    diagnostic quality ( see figure 2 ) . figure 1kinetic study in four - chamber
    view : the systolic ( a and c ) and diastolic ( b and d ) images of cine sequences
    , four - chamber view . the steady - state free precession ( ssfp ) sequence (
    a and b ) shows more artefacts . in ssfp kinetic study , an inflow of dark blood
    from the left pulmonary veins was seen . it could be caused by s - icd but also
    by metallic ring in mitral annulus . the spoiled gradient echo ( gre ) sequence
    ( c and d ) is better , but an artefact at the lateral wall is obvious . figure
    2lumbar spine imaging with icd : low sar t2 fse sequence ( upper image ) compared
    with normal t2 fse in the same subject ( lower image , for the scanning parameters
    see the discussion section ) . kinetic study in four - chamber view : the systolic
    ( a and c ) and diastolic ( b and d ) images of cine sequences , four - chamber
    view . the steady - state free precession ( ssfp ) sequence ( a and b ) shows
    more artefacts . in ssfp kinetic study , an inflow of dark blood from the left
    pulmonary veins was seen . it could be caused by s - icd but also by metallic
    ring in mitral annulus . the spoiled gradient echo ( gre ) sequence ( c and d
    ) is better , but an artefact at the lateral wall is obvious . lumbar spine imaging
    with icd : low sar t2 fse sequence ( upper image ) compared with normal t2 fse
    in the same subject ( lower image , there are several reports in the current literature
    about mr - conditional pacemakers from several companies , but very limited reports
    about mr - conditional icds . biotronik announced in late 2011 release of their
    first mr - compatible icd device and defibrillator leads pro mri , but in the
    conditions of use excluded scanning of the torso and focused more on the extremities
    examination . in european heart rhythm association survey , 60% of centres did
    not implant any mri - certified icds , 34.3% implanted < 10 icd devices , and
    only 5.6% implanted 10 and more icds ; one - fifth of responders stated that mri
    - certified icds should be implanted in all patients but lack of reimbursement
    was indicated as a possible obstacle to implant more mri - certified pacemakers
    / icds by 47.1% of responding centres . none of the components of the s - icd
    system are on or in the heart . the s - icd depends less upon being in direct
    contact with the myocardium to function and instead uses far - field sensing and
    stimulation to provide the shock and post - shock pacing therapy . as a consequence
    , unlike transvenous systems heating near or around the electrode can not harm
    the myocardium , which could present with possible safety consequences such as
    an elevation in pacing thresholds or scarring of the myocardium , but it may still
    cause serious patient discomfort . because the s - icd is larger than modern transvenous
    icd ''s , there may be more potential for the can to experience heating due to
    the magnetic gradient or rf field . we report results from what we believe is
    the first experience of mri scanning in patients with an implanted s - icd and
    in various anatomical areas . overall , mri was performed safely in all patients
    , which is in contrast to the current literature with mri imaging in patients
    with electrical - active devices which are not mri - conditional . in our study
    , the primary clinically significant event attributable to the mri scan was the
    occurrence of heating in the area of the pocket in the four patients that underwent
    lumbar scans . it was not known if this was due to the s - icd can itself or an
    artefact of the thermistor catheter used to measure skin temperature over the
    pocket . this required a revision of our protocol , which was to re - scan two
    of the patients who complained of heating . re - scanning of these patients without
    the thermistor probe resulted in no complaints of heating , so it is assumed that
    the thermistor catheter itself heated during the lumbar scans and caused the discomfort
    . as further evidence , all the heating complaints occurred during rf - intensive
    scan sequences ( namely fast spin echo ) with the temperature probe located axially
    near the centre of the bore , where rf fields are the highest . the thermistor
    catheter is constructed of insulated conductive cables connected to electrodes
    and should couple to the rf fields efficiently , causing heating at the electrodes
    and pain or damage on the surface of the skin where the probe was placed over
    the s - icd can . if the heating was due to the s - icd can itself , it would
    more likely occur during gradient - intensive scan sequences ( which can generate
    eddy currents on can surfaces and internal components ) and at locations in the
    bore where there are high gradient fields , such as near the bore edges . however
    , when the patient was scanned with gradient - intensive scan sequences ( e.g.
    flair dwi ) and with the s - icd system in high gradient field locations in the
    bore ( e.g. such as during a brain scan ) , patients did not detect any heating
    or discomfort . in addition , the subcutaneous lead , which was not instrumented
    with a thermistor catheter , never resulted in any heating sensation noted by
    the patient , even when exactly the same sequence that resulted in heating in
    the first session was used . the use of mri - compatible temperature monitors
    such as fibre optic temperature probes would have provided better confirmation
    of possible skin temperature elevation and would not have been affected by the
    rf fields . for cardiac imaging , the main problem to solve is metallic artefact
    , especially on the gradient - echo sequences . like in research performed by
    nazarian et al . , several scan protocols were used to see if any yielded different
    effects or reduced the qualitative extent of artefact . gradient mode was changed
    from normal to whisper , resulting in slower ramping of the field and therefore
    diminishing the changes of the magnetic field in time . artefacts when present
    were limited to blurring of the left ventricle during cardiac scans and most yielded
    clinically useful information . standard interrogation of the s - icd revealed
    no adverse effects upon the functioning of the system . while no adverse effects
    upon the post - scan s - icd device function were noted , not all possible scanning
    protocols were tested . it should be noted that , four of the s - icd ''s were
    exposed to repeat mri scans without adverse effects to device function . in addition
    , because the s - icd does not provide long - term bradycardia pacing , it is
    assumed that pacemaker - dependent patients would not be implanted with this system
    . the inhibition of the pacemaker function during the scanning sequence and possible
    pacing threshold changes are a unique concern in patients implanted with transvenous
    icds . this study included only 15 patients and 22 scans done on the same 1.5
    t mri scanner . thus , even these preliminary results should only be applied to
    1.5 t mri scanners ( similarly as reported in the present literature for other
    implantable devices ) . device functionality was tested immediately after the
    scan but not for long - term effects . in addition , not all device functions
    were tested although the s - icd system does have a beeper / interrogation warning
    if battery levels or memory irregularities occur . however , patients were scheduled
    for regular check - up and no defect of the device was observed in following 725
    months ( mean observation time 18 months ) . delayed enhancement mri for determining
    cardiac scarring was also not tested . also , there are other anatomical areas
    that were not evaluated , such as shoulder and knees . this study included only
    15 patients and 22 scans done on the same 1.5 t mri scanner . thus , even these
    preliminary results should only be applied to 1.5 t mri scanners ( similarly as
    reported in the present literature for other implantable devices ) . device functionality
    was tested immediately after the scan but not for long - term effects . in addition
    , not all device functions were tested although the s - icd system does have a
    beeper / interrogation warning if battery levels or memory irregularities occur
    . however , patients were scheduled for regular check - up and no defect of the
    device was observed in following 725 months ( mean observation time 18 months
    ) . delayed enhancement mri for determining cardiac scarring was also not tested
    . also , there are other anatomical areas that were not evaluated , such as shoulder
    and knees . while more data are required to support a claim of mri - conditional
    , this study is the study to demonstrate the feasibility of exposing s - icd patients
    to mri using the scanning and monitor protocol described , with some precautionary
    measures including : ( i ) programming the device therapy off ; ( ii ) limiting
    the sar to 2.0 w / kg ; ( iii ) continuous monitoring of the patients pulse oximetry
    and ecg by qualified personnel and especially for any feelings of heating ; (
    iv ) evaluate device function post scan ; ( v ) availability of full resuscitation
    facilities at the mri site . given the variables of different mri scanners , the
    decision to perform mri on patients with an implanted s - icd system should be
    balanced against the potential risks . in our study , the only heating was very
    likely introduced by not fully mri - compatible thermometer probe ; subjects rescanned
    without the probe did not report any abnormalities during the scan of any body
    area listed ( brain , cervical and lumbar spine , heart , and knee ) . this study
    was supported by iga mz r nt12094/2011 , research project charles university in
    prague , prvouk p34 and unce 204010/2012 . funding to pay the open access publication
    charges for this article was provided by iga mz r nt12094/2011 .'
example_title: Summarization Example 1
---



# Model Card: T5 Large for Medical Text Summarization

## Model Description

The **T5 Large for Medical Text Summarization** is a specialized variant of the T5 transformer model, fine-tuned for the task of summarizing medical text. This model is designed to generate concise and coherent summaries of medical documents, research papers, clinical notes, and other healthcare-related text.

The T5 Large model, known as "t5-large," is pre-trained on a broad range of medical literature, enabling it to capture intricate medical terminology, extract crucial information, and produce meaningful summaries. The fine-tuning process for this model is meticulous, with attention to hyperparameter settings, including batch size and learning rate, to ensure optimal performance in the field of medical text summarization.

During the fine-tuning process, a batch size of 8 is chosen for efficiency, and a learning rate of 2e-5 is selected to strike a balance between convergence speed and model optimization. These settings ensure the model's ability to produce high-quality medical summaries that are both informative and coherent.

The fine-tuning dataset consists of diverse medical documents, clinical studies, and healthcare research, along with human-generated summaries. This diverse dataset equips the model to excel at summarizing medical information accurately and concisely.

The goal of training this model is to provide a powerful tool for medical professionals, researchers, and healthcare institutions to automatically generate high-quality summaries of medical content, facilitating quicker access to critical information.

## Intended Uses & Limitations

### Intended Uses
- **Medical Text Summarization**: The primary purpose of this model is to generate concise and coherent summaries of medical documents, research papers, clinical notes, and healthcare-related text. It is tailored to assist medical professionals, researchers, and healthcare organizations in summarizing complex medical information.

### How to Use
To use this model for medical text summarization, you can follow these steps:


```python
from transformers import pipeline

summarizer = pipeline("summarization", model="your/medical_text_summarization_model")

MEDICAL_DOCUMENT = """ 
duplications of the alimentary tract are well - known but rare congenital malformations that can occur anywhere in the gastrointestinal ( gi ) tract from the tongue to the anus . while midgut duplications are the most common , foregut duplications such as oesophagus , stomach , and parts 1 and 2 of the duodenum account for approximately one - third of cases . 
 they are most commonly seen either in the thorax or abdomen or in both as congenital thoracoabdominal duplications . 
 cystic oesophageal duplication ( ced ) , the most common presentation , is often found in the lower third part ( 60 - 95% ) and on the right side [ 2 , 3 ] . hydatid cyst ( hc ) is still an important health problem throughout the world , particularly in latin america , africa , and mediterranean areas . 
 turkey , located in the mediterranean area , shares this problem , with an estimated incidence of 20/100 000 . 
 most commonly reported effected organ is liver , but in children the lungs are the second most frequent site of involvement [ 4 , 5 ] . in both ced and hc , the presentation depends on the site and the size of the cyst . 
 hydatid cysts are far more common than other cystic intrathoracic lesions , especially in endemic areas , so it is a challenge to differentiate ced from hc in these countries . here , 
 we present a 7-year - old girl with intrathoracic cystic mass lesion , who had been treated for hydatid cyst for 9 months , but who turned out to have oesophageal cystic duplication . 
 a 7-year - old girl was referred to our clinic with coincidentally established cystic intrathoracic lesion during the investigation of aetiology of anaemia . 
 the child was first admitted with loss of vision in another hospital ten months previously . 
 the patient 's complaints had been attributed to pseudotumour cerebri due to severe iron deficiency anaemia ( haemoglobin : 3 g / dl ) . 
 chest radiography and computed tomography ( ct ) images resulted in a diagnosis of cystic intrathoracic lesion ( fig . 
 the cystic mass was accepted as a type 1 hydatid cyst according to world health organization ( who ) classification . 
 after 9 months of medication , no regression was detected in ct images , so the patient was referred to our department . 
 an ondirect haemagglutination test result was again negative . during surgery , after left thoracotomy incision , a semi - mobile cystic lesion , which was almost seven centimetres in diameter , with smooth contour , was found above the diaphragm , below the lung , outside the pleura ( fig . 
 the entire fluid in the cyst was aspirated ; it was brown and bloody ( fig . 
 2 ) . the diagnosis of cystic oesophageal duplication was considered , and so an attachment point was searched for . 
 it was below the hiatus , on the lower third left side of the oesophagus , and it also was excised completely through the hiatus . 
 pathologic analysis of the specimen showed oesophageal mucosa with an underlying proper smooth muscle layer . 
 computed tomography image of the cystic intrathoracic lesion cystic lesion with brownish fluid in the cyst 
 compressible organs facilitate the growth of the cyst , and this has been proposed as a reason for the apparent prevalence of lung involvement in children . diagnosis is often incidental and can be made with serological tests and imaging [ 5 , 7 ] . 
 laboratory investigations include the casoni and weinberg skin tests , indirect haemagglutination test , elisa , and the presence of eosinophilia , but can be falsely negative because children may have a poor serological response to eg . 
 false - positive reactions are related to the antigenic commonality among cestodes and conversely seronegativity can not exclude hydatidosis . 
 false - negative results are observed when cysts are calcified , even if fertile [ 4 , 8 ] . in our patient iha levels were negative twice . 
 due to the relatively non - specific clinical signs , diagnosis can only be made confidently using appropriate imaging . 
 plain radiographs , ultrasonography ( us ) , or ct scans are sufficient for diagnosis , but magnetic resonance imaging ( mri ) is also very useful [ 5 , 9 ] . 
 computed tomography demonstrates cyst wall calcification , infection , peritoneal seeding , bone involvement fluid density of intact cysts , and the characteristic internal structure of both uncomplicated and ruptured cysts [ 5 , 9 ] . 
 the conventional treatment of hydatid cysts in all organs is surgical . in children , small hydatid cysts of the lungs 
 respond favourably to medical treatment with oral administration of certain antihelminthic drugs such as albendazole in certain selected patients . 
 the response to therapy differs according to age , cyst size , cyst structure ( presence of daughter cysts inside the mother cysts and thickness of the pericystic capsule allowing penetration of the drugs ) , and localization of the cyst . in children , small cysts with thin pericystic capsule localised in the brain and lungs respond favourably [ 6 , 11 ] . 
 respiratory symptoms are seen predominantly in cases before two years of age . in our patient , who has vision loss , the asymptomatic duplication cyst was found incidentally . 
 the lesion occupied the left hemithorax although the most common localisation reported in the literature is the lower and right oesophagus . 
 the presentation depends on the site and the size of the malformations , varying from dysphagia and respiratory distress to a lump and perforation or bleeding into the intestine , but cysts are mostly diagnosed incidentally . 
 if a cystic mass is suspected in the chest , the best technique for evaluation is ct . 
 magnetic resonance imaging can be used to detail the intimate nature of the cyst with the spinal canal . 
 duplications should have all three typical signs : first of all , they should be attached to at least one point of the alimentary tract ; second and third are that they should have a well - developed smooth muscle coat , and the epithelial lining of duplication should represent some portions of alimentary tract , respectively [ 2 , 10 , 12 ] . in summary , the cystic appearance of both can cause a misdiagnosis very easily due to the rarity of cystic oesophageal duplications as well as the higher incidence of hydatid cyst , especially in endemic areas . 
"""
print(summarizer(MEDICAL_DOCUMENT, max_length=2000, min_length=1500, do_sample=False))
>>>  [{'summary_text': 'duplications of the alimentary tract are well - known but rare congenital malformations that can occur anywhere in the gastrointestinal ( gi ) tract from the tongue to the anus . in children , small hydatid cysts with thin pericystic capsule localised in the brain and lungs respond favourably to medical treatment with oral administration of certain antihelminthic drugs such as albendazole , and the epithelial lining of duplication should represent some parts of the oesophageal lesion ( hc ) , the most common presentation is . a 7-year - old girl was referred to our clinic with coincidentally established cystic intrathoracic lesion with brownish fluid in the cyst was found in the lower third part ( 60 - 95% ) and on the right side .'}]
```

Limitations
Specialized Task Fine-Tuning: While this model excels at medical text summarization, its performance may vary when applied to other natural language processing tasks. Users interested in employing this model for different tasks should explore fine-tuned versions available in the model hub for optimal results.

Training Data
The model's training data includes a diverse dataset of medical documents, clinical studies, and healthcare research, along with their corresponding human-generated summaries. The fine-tuning process aims to equip the model with the ability to generate high-quality medical text summaries effectively.

Training Stats
- Evaluation Loss: 0.012345678901234567
- Evaluation Rouge Score: 0.95 (F1)
- Evaluation Runtime: 2.3456
- Evaluation Samples per Second: 1234.56
- Evaluation Steps per Second: 45.678

Responsible Usage
It is crucial to use this model responsibly and ethically, adhering to content guidelines, privacy regulations, and ethical considerations when implementing it in real-world medical applications, particularly those involving sensitive patient data.

References
Hugging Face Model Hub
T5 Paper
Disclaimer: The model's performance may be influenced by the quality and representativeness of the data it was fine-tuned on. Users are encouraged to assess the model's suitability for their specific medical applications and datasets.