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12
https://data.codatta.io/eb00cbed-63c4-4d47-9b6a-9dde1306b8cd
eb00cbed-63c4-4d47-9b6a-9dde1306b8cd
TCGA-KK-A7B2-01Z-00-DX1.3E779031-6FE4-4BD0-838C-D9ED49E1B9A7.svs
Gleason Score 5+4
This slide contains predominately Gleason Grade 5 tumor, characterized by the absence of glandular differentiation, alongside Gleason Grade 4 tumor, characterized by glandular fusion or colloid structure or cribriform structure.
4
https://data.codatta.io/cfe0818a-1baf-407f-a43d-373725e3e581
cfe0818a-1baf-407f-a43d-373725e3e581
TCGA-G9-6342-01Z-00-DX1.5ea9bcc5-b2ce-4aef-a89d-c02eb3fd8910.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by Discrete and well-formed glands, alongside Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure.
2
https://data.codatta.io/c6754722-a9ca-49c6-bd71-3188fd5068d6
c6754722-a9ca-49c6-bd71-3188fd5068d6
TCGA-J4-A67N-01Z-00-DX1.3253614F-8B3D-4337-96C5-BF842DCAA35C.svs
null
labeled regions has more glands fusing than individual glands, qualifying for G4+3
5
https://data.codatta.io/9f8bf716-57fa-40aa-b003-c2410796b92a
9f8bf716-57fa-40aa-b003-c2410796b92a
TCGA-XK-AAJ3-01Z-00-DX1.48C36FDF-232A-49BC-AAB5-4B8BFB215743.svs
null
Although this slide is mostly G4, there is more than 5% of G3 found and labeled indicating this slide is GS 4+3
5
https://data.codatta.io/363957ce-7840-4c54-9905-3a71ef7b8b54
363957ce-7840-4c54-9905-3a71ef7b8b54
TCGA-HC-7742-01Z-00-DX1.59cf7b97-16a4-4c83-b4e0-6ee292326500.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
5
https://data.codatta.io/4cef7f53-70a1-44d0-8796-73d8abc3c92a
4cef7f53-70a1-44d0-8796-73d8abc3c92a
TCGA-G9-A9S0-01Z-00-DX1.790729D2-1AF4-4ACF-A470-A9ADC786298E.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason grade tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor area of Gleason Grade 5 tumor was found, exhibiting Cord-like structure, or appear as individual nuclei, both absence of glandular differentiation.
5
https://data.codatta.io/202e9943-0192-434f-b2c0-96ef8a75ca4f
202e9943-0192-434f-b2c0-96ef8a75ca4f
TCGA-V1-A9Z9-01Z-00-DX1.CB27F8C0-FADF-4010-904D-125FE17AE8B3.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands that lacks a basal cell layer. Minor regions of Gleason Grade 5 were found, where glandular difference is absent.
9
https://data.codatta.io/842d2efb-a768-480d-bebb-a526eae100df
842d2efb-a768-480d-bebb-a526eae100df
TCGA-G9-6494-01Z-00-DX1.023d173a-85dc-4814-9c1e-449f491eb444.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands that lacks a basal cell layer, alongside Gleason Grade 4 tumor, characterized by glandular fusion.
4
https://data.codatta.io/9fb7166a-c901-421e-b48f-daae8851e5b8
9fb7166a-c901-421e-b48f-daae8851e5b8
TCGA-XK-AAIV-01Z-00-DX1.50BEF025-FAD6-404F-9385-D58C97FC03CC.svs
Gleason Score 5+4
This slide contains predominately Gleason Grade 5 tumor, where glandular differentiation is absent, alongside Gleason Grade 3 tumor with discrete and well-formed glands. However, there is more than 5% of Grade 4 glands, characterized by glandular fusion, which makes the slide Grade 5+4.
7
https://data.codatta.io/27a351b7-1866-4a65-8af9-90aad0cc207b
27a351b7-1866-4a65-8af9-90aad0cc207b
TCGA-YL-A9WJ-01Z-00-DX1.ECE31D79-8A8E-45DB-8BC4-97B303D38B1B.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
5
https://data.codatta.io/400fea7d-8200-47f5-9df2-5c4e73f8251e
400fea7d-8200-47f5-9df2-5c4e73f8251e
TCGA-V1-A9OQ-01Z-00-DX1.6B57FA2E-B1D8-4CA4-B0E7-401A33ED93B4.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands that lacks a layer of basal cell. Minor Gleason Grade 4 tumor was also found, exhibiting glandular fusion.
3
https://data.codatta.io/fb2eeab4-3788-4a21-8673-620c4827e7c3
fb2eeab4-3788-4a21-8673-620c4827e7c3
TCGA-HC-A76X-01Z-00-DX1.DBB52520-F96D-45AD-9228-BA81B7553824.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor mixed with benign glands, Gleason Grade 3 tumor can be characterized by discrete and well-formed glands that lacks a layer of basal cell.
1
https://data.codatta.io/b5d322a2-461f-4549-9e4c-c272b8188c3e
b5d322a2-461f-4549-9e4c-c272b8188c3e
TCGA-EJ-A46B-01Z-00-DX1.16F1652C-010D-4CDA-A4D7-B32FF09F22B0.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was found, identified by the absence of glandular differentiation.
5
https://data.codatta.io/3b57f43a-44ec-4632-b673-e5104f2ddea1
3b57f43a-44ec-4632-b673-e5104f2ddea1
TCGA-VP-A879-01Z-00-DX1.FC957319-7D9E-4480-B279-D42D5FFD2A4B.svs
Gleason Score 5+4
This slide contains predominately Gleason Grade 5 tumor, characterized by the absence of glandular differentiation, alongside Gleason Grade 4 tumor characterized by glandular fusion.
1
https://data.codatta.io/8c39e52d-b850-4d72-986f-85aa7bb14052
8c39e52d-b850-4d72-986f-85aa7bb14052
TCGA-HI-7169-01Z-00-DX1.ac873262-34a1-4a47-8178-6a2a279c02e5.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, that lacks a layer of basal cell.
1
https://data.codatta.io/7981b5a9-eb12-422e-aafb-2488339e7340
7981b5a9-eb12-422e-aafb-2488339e7340
TCGA-G9-6378-01Z-00-DX1.c06b70ec-64ee-4db0-8682-72c1cc0e97bc.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
12
https://data.codatta.io/e0b6ea1b-a814-4414-8755-a0ef38c7cceb
e0b6ea1b-a814-4414-8755-a0ef38c7cceb
TCGA-V1-A9OX-01Z-00-DX1.E4FD5D9C-6634-4410-943F-3F389141183E.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor, Gleason Grade 5 tumor was found mixed with Grade 4 tumor in Grade 4+5 region, where Grade 5 tumor can be identified by the absence of glandular differentiation.
4
https://data.codatta.io/9e562bf3-1cb4-48e1-a2d2-ea43cd496c86
9e562bf3-1cb4-48e1-a2d2-ea43cd496c86
TCGA-YL-A8SK-01Z-00-DX1.806C30FC-7C27-46A5-8EF7-BBCC5D8738DC.svs
Gleason Score 5+3
This slide contains predominately Gleason Grade 5 tumor, characterized by the absence of glandular differentiation, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
6
https://data.codatta.io/f63e797f-621e-4618-bb92-82c5a5197a59
f63e797f-621e-4618-bb92-82c5a5197a59
TCGA-YL-A8SK-01Z-00-DX3.6DB3959A-555D-433E-94D2-58E7C37CA01B.svs
Gleason Score 5+3
This slide contains predominately Gleason Grade 5 tumor, characterized by the lack of glandular differentiation, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
3
https://data.codatta.io/d444e3bf-7756-464a-90b5-cecd132d94a8
d444e3bf-7756-464a-90b5-cecd132d94a8
TCGA-YL-A8SK-01Z-00-DX2.AFB7A0C8-33A5-4D5F-AA0F-428E79FD03F6.svs
Gleason Score 5+4
This slide contains predominately Gleason Grade 5 tumor, characterized by the absence of glandular differentiation, alongside Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure.
2
https://data.codatta.io/61250bf7-16a6-4f16-b127-9030f1e6b829
61250bf7-16a6-4f16-b127-9030f1e6b829
TCGA-VP-A87B-01Z-00-DX1.E11AE7F4-676D-4A0E-A184-5BAE01ABD432.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
2
https://data.codatta.io/e896c268-b9a7-42e7-b958-c9f894d30a25
e896c268-b9a7-42e7-b958-c9f894d30a25
TCGA-EJ-5515-01Z-00-DX1.4cfd0e05-b10c-4193-a488-9277cd60f0ea.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was found, identified by the absence of glandular differentiation.
4
https://data.codatta.io/bd9345b3-50c3-4d89-8b34-45ca11cfed13
bd9345b3-50c3-4d89-8b34-45ca11cfed13
TCGA-YL-A9WH-01Z-00-DX1.7240AB29-F661-4456-A68D-B0FF40F553B8.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by the discrete and well-formed glands.
1
https://data.codatta.io/9bf676b1-c3ec-45cc-8f19-20332cb52871
9bf676b1-c3ec-45cc-8f19-20332cb52871
TCGA-KK-A8IG-01Z-00-DX1.57499D3B-8589-4A1A-A295-A17B48704A54.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was found in cord-like structure or as individual nuclei, both lacking glandular differentiation.
6
https://data.codatta.io/c506cd50-9892-4b04-8f59-57bb9d7f705d
c506cd50-9892-4b04-8f59-57bb9d7f705d
TCGA-EJ-5505-01Z-00-DX1.8e43f020-053f-47d9-842d-4d30a776ffd2.svs
Gleason Score 3+4 with Minor 5
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor, characterized by glandular fusion. Minor Gleason Grade 5 was found, identified by small clusters of tumor nuclei that lacks glandular differentiation completely.
4
https://data.codatta.io/8afc3e55-fcaf-4328-9b5a-a01bcee181cc
8afc3e55-fcaf-4328-9b5a-a01bcee181cc
TCGA-EJ-7789-01Z-00-DX1.1fe607cd-e166-4c16-8fc0-74bcca9b5975.svs
Gleason Score 4+4 with Minor 5
The only area containing Grade 3 is the Grade 3+4 area on the top, where it also contains Grade 4 glands that's fusing and missing lumen. This slide is Graded as 4+4 because not enough Grade 3 was found. Also, minor clusters of Grade 5 lacking glandular formation were found.
3
https://data.codatta.io/47af7248-92f4-4111-a215-15dc28148585
47af7248-92f4-4111-a215-15dc28148585
TCGA-EJ-5516-01Z-00-DX1.50003728-b68b-4e22-96d8-8fce43a03274.svs
Gleason Score 4+3
This slide contains predominately, Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
1
https://data.codatta.io/6dbcf931-fe34-41e6-8731-93518818a5a2
6dbcf931-fe34-41e6-8731-93518818a5a2
TCGA-XK-AAIW-01Z-00-DX1.31B98849-4AA9-4AC1-A697-A0C4165976B5.svs
Gleason Score 5+5
This slide contains predominately Gleason Grade 5 tumor, characterized by solid sheet structure, or comedonecrosis pattern, or in some regions Grade 5 with minimal glandular difference.
1
https://data.codatta.io/b01f25f2-871f-4c5b-952a-3cd3f2299022
b01f25f2-871f-4c5b-952a-3cd3f2299022
TCGA-HC-7741-01Z-00-DX1.77D97B8B-ECAB-4BB3-97F3-67BFE05E7F54.svs
Gleason Score 5+4
This slide contains predominately Gleason Grade 5 tumor, characterized by the absence of glandular difference, or nest form structure, alongside Gleason Grade 4 tumor, characterized by glandular fusion.
2
https://data.codatta.io/bec39ffa-a8b7-4b85-85c4-3d917dcee907
bec39ffa-a8b7-4b85-85c4-3d917dcee907
TCGA-YL-A8SL-01Z-00-DX1.6758D124-1154-4D76-8569-72A1C148F64C.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor characterized by cribriform structure.
2
https://data.codatta.io/28adf83e-1fb4-4dad-b0d2-95940886ebee
28adf83e-1fb4-4dad-b0d2-95940886ebee
TCGA-YL-A8SL-01Z-00-DX3.D85D40A5-172E-4A33-97BE-54EF0FC01A75.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor characterized by glandular fusion.
1
https://data.codatta.io/c999d84e-149a-435e-8c9e-0ee10ee26947
c999d84e-149a-435e-8c9e-0ee10ee26947
TCGA-VP-A87K-01Z-00-DX1.A1BED19B-7C83-4B88-A869-B138713A2292.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
2
https://data.codatta.io/0ce3b88b-e903-4b4d-8ca9-af4b2ea132d1
0ce3b88b-e903-4b4d-8ca9-af4b2ea132d1
TCGA-KK-A6E7-01Z-00-DX1.00AF21EA-5532-4BE7-8269-18027B019865.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 5 tumor characterized by the complete lack of glandular differentiation.
2
https://data.codatta.io/cae927fc-4ac9-4318-85f0-0684044661a2
cae927fc-4ac9-4318-85f0-0684044661a2
TCGA-KK-A8I9-01Z-00-DX1.8DD81B98-3C5B-4F54-A1E9-0966E12205E3.svs
Gleason Score 4+4 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen. Minor Grade 5 tumor was found, where glandular differentiation is absent.
3
https://data.codatta.io/3b42fbec-0d4b-4283-a424-28df04d825e0
3b42fbec-0d4b-4283-a424-28df04d825e0
TCGA-HC-8257-01Z-00-DX1.f11b1c83-b2d6-4e96-af6f-672bcf6719f4.svs
Gleason Score 4+4 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen. There is also a mixture of Gleason Grade 5 tumor nuclei and lymphocytes, where Gleason Grade 5 tumor cells exhibit large, pleomorphic nuclei, which lack glandular differentiation.
2
https://data.codatta.io/c38c17ab-f53a-4772-a99e-5126bbc52fa2
c38c17ab-f53a-4772-a99e-5126bbc52fa2
TCGA-G9-A9S7-01Z-00-DX1.E46D2A59-1B23-4841-B327-C9AAE176AD2D.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside denser regions of Gleason Grade 5 tumor, where glandular differentiation is absent.
2
https://data.codatta.io/3dc0e394-dd06-4e7d-b85b-dac258c1ed95
3dc0e394-dd06-4e7d-b85b-dac258c1ed95
TCGA-YL-A8SA-01Z-00-DX1.B246D547-9875-42DB-8BD9-206C449EF089.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was found, identified by the absence of glandular differentiation.
3
https://data.codatta.io/0fa45562-ad26-4758-b417-cb4f906ccd96
0fa45562-ad26-4758-b417-cb4f906ccd96
TCGA-KK-A8IL-01Z-00-DX1.C91F74AC-39D4-44BB-A48B-F4AACA135007.svs
Gleason Score 3+4 with Minor 5
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor, characterized by glandular fusion. Minor Gleason Grade 5 tumor was found, where glandular differentiation is absent.
4
https://data.codatta.io/407bbca8-12b2-422e-94d5-f481cb3f8bd4
407bbca8-12b2-422e-94d5-f481cb3f8bd4
TCGA-EJ-7315-01Z-00-DX1.6e08c383-ca90-45ad-8a26-de89823c333f.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was found, identified by small clusters of tumor nuclei lacking glandular differentiation.
3
https://data.codatta.io/54b06bd5-207a-4f71-8797-c3654ee797fb
54b06bd5-207a-4f71-8797-c3654ee797fb
TCGA-HC-7750-01Z-00-DX1.a1457c89-5f31-4863-99e4-5675dfb9fef1.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
1
https://data.codatta.io/a1ab0837-d779-4921-b48f-bd387ada12b2
a1ab0837-d779-4921-b48f-bd387ada12b2
TCGA-YL-A9WI-01Z-00-DX4.DD0313AF-7339-45F1-B3CF-AE9C20679E7F.svs
Gleason Score 3+4
This slide contains predominately Grade 3 tumor with discrete and well-formed glands, alongside Gleason Grade 4 tumor characterized by glandular fusion or cribriform structure.
3
https://data.codatta.io/9ef5628e-a9d9-430a-9391-a34c1db0fb3c
9ef5628e-a9d9-430a-9391-a34c1db0fb3c
TCGA-YL-A9WI-01Z-00-DX3.51D0394E-FB44-4878-B761-9460D3833207.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion, alongside areas of Gleason Grade 3 tumor, where glands remain discrete and well-formed.
3
https://data.codatta.io/ac6d620c-bfb4-40a1-90da-931ab51bcbab
ac6d620c-bfb4-40a1-90da-931ab51bcbab
TCGA-YL-A9WI-01Z-00-DX2.33951B3A-6591-471C-9F4F-EAAEF761CBEE.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor near the top left, where glands are discrete and well-formed. Minor Grade 5 tumor was also found, identified by the absence of glandular differentiation.
4
https://data.codatta.io/7555ba36-2f12-4669-b942-3b377ffa22b6
7555ba36-2f12-4669-b942-3b377ffa22b6
TCGA-YL-A9WI-01Z-00-DX1.7BEF88F1-9093-41C0-834C-7DD4A332455E.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Grade 5 tumor was also found, identified by the absence of glandular differentiation.
4
https://data.codatta.io/79d50e2b-0068-4e11-ab35-eeb1f102b51a
79d50e2b-0068-4e11-ab35-eeb1f102b51a
TCGA-V1-A8MG-01Z-00-DX1.E141371C-B88D-4EE9-B65E-9C9DEC4EAA70.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 5 tumor, characterized by the absence of glandular differentiation.
4
https://data.codatta.io/d691fafd-8c5f-46c8-bffb-8f1185f055b7
d691fafd-8c5f-46c8-bffb-8f1185f055b7
TCGA-FC-A4JI-01Z-00-DX1.05793978-083B-4332-91D3-8843E5115808.svs
Gleason Score 4+4
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure.
1
https://data.codatta.io/a8ddc76c-36cf-4b28-a546-9d60ea292cd6
a8ddc76c-36cf-4b28-a546-9d60ea292cd6
TCGA-KK-A8I8-01Z-00-DX1.9C138C77-7DD7-4EE0-A34C-D4B629E18087.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was also found mixed with Grade 3, identified by tumor nuclei that exists individually, lacking glandular differentiation completely.
3
https://data.codatta.io/dbda78ed-68ba-4c84-80d8-04f8e422672b
dbda78ed-68ba-4c84-80d8-04f8e422672b
TCGA-V1-A9ZR-01Z-00-DX1.09668B8E-0AFA-4252-ABF1-BA7BD5D301B6.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 5 tumor near the top left, characterized by the absence of glandular differentiation.
3
https://data.codatta.io/03868640-990b-43d7-8d2f-bc96d9b903ae
03868640-990b-43d7-8d2f-bc96d9b903ae
TCGA-YL-A8HK-01Z-00-DX1.9A095D1F-A8CA-4BE4-9B42-83BC45FE54D7.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Grade 5 tumor was also found, identified by the absence of glandular differentiation.
3
https://data.codatta.io/b6a5843f-0c71-4345-b2a8-fead77cb5378
b6a5843f-0c71-4345-b2a8-fead77cb5378
TCGA-G9-6343-01Z-00-DX1.e5756f91-d1a7-4cb4-8140-e93bb92bf194.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure.
3
https://data.codatta.io/4b125ddc-f635-4c50-a212-39ce031204ee
4b125ddc-f635-4c50-a212-39ce031204ee
TCGA-KK-A7AU-01Z-00-DX1.5DA62B04-B06C-4EBB-9512-F96D3A83D549.svs
Gleason Score 4+4
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure.
1
https://data.codatta.io/0230931b-6450-4f4e-97a2-b31184527132
0230931b-6450-4f4e-97a2-b31184527132
TCGA-H9-A6BX-01Z-00-DX1.B73DC319-AE9E-4B6E-8540-8A870B0246D2.svs
Benign
This slide contains only benign glands, as evidenced by the presence of an intact layer of basal cells.
2
https://data.codatta.io/fffd0cf9-8343-421c-9f0b-9cd3f904f1b8
fffd0cf9-8343-421c-9f0b-9cd3f904f1b8
TCGA-HC-A6HY-01Z-00-DX1.9753A5EC-6068-4502-ACBB-4C6F1EA77AF9.svs
Gleason Score 3+3
This slide contains Gleason Grade 3 tumor, characterized by the absence of basal cells and the presence of enlarged nuclei.
1
https://data.codatta.io/5d146801-e68f-40c4-b4f4-02c7e882d6c6
5d146801-e68f-40c4-b4f4-02c7e882d6c6
TCGA-HC-8265-01Z-00-DX1.f0d35c7c-697c-4589-8783-ba258ed0155d.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by fused glands or absent lumen, alongside small amount of Gleason Grade 3 tumor where glands are discrete, and lumens are still intact.
1
https://data.codatta.io/9f7fbd02-67ea-4b15-a3ed-98c51daecaa4
9f7fbd02-67ea-4b15-a3ed-98c51daecaa4
TCGA-KK-A8IF-01Z-00-DX1.D89CE36A-8166-4CA5-82DE-A937ABBF14D0.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Grade 5 tumor with no glandular differentiation was also found near the bottom right.
5
https://data.codatta.io/9513e463-f98c-4366-952e-e3554329093a
9513e463-f98c-4366-952e-e3554329093a
TCGA-M7-A722-01Z-00-DX1.92921857-7A4A-4BE7-BF3E-8805C6397713.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by fused gland and cribriform structure. Right side of the slide also contains Gleason Grade 5 tumor where tumor nuclei is denser and missing glandular differentiation.
2
https://data.codatta.io/292a0413-2ccb-40d1-89ee-6666c6495311
292a0413-2ccb-40d1-89ee-6666c6495311
TCGA-HC-A6AQ-01Z-00-DX1.23957370-CCE3-49C2-AE21-4591DCE47E86.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
1
https://data.codatta.io/1f7623b7-fe59-422c-8376-a040c2bdc656
1f7623b7-fe59-422c-8376-a040c2bdc656
TCGA-EJ-7328-01Z-00-DX1.577d603f-8bab-4fa5-801b-d7e999edca25.svs
Gleason Score 3+4
This slide contains predominantly Gleason Grade 3 tumor where glands are discrete and well separated, alongside Gleason Grade 4 tumor, where glands are fusing or missing lumen.
1
https://data.codatta.io/4d62c71b-6eb0-4ef1-aba5-acdd7e82d630
4d62c71b-6eb0-4ef1-aba5-acdd7e82d630
TCGA-J4-A67T-01Z-00-DX1.CF24F5B1-8583-4DEB-BDE8-45786116488E.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 4 tumor was found, where glands are fusing or missing lumen.
4
https://data.codatta.io/4c27ee52-ab9d-4929-83a3-685b5c534f7f
4c27ee52-ab9d-4929-83a3-685b5c534f7f
TCGA-HC-A9TH-01Z-00-DX1.13526861-B926-4CF5-9E99-D4A8FFFBBE7C.svs
Gleason Score 4+4
This slide contains predominately Gleason Grade 4 tumor, exhibiting glandular fusion or cribriform structure.
1
https://data.codatta.io/aa4b83ea-9bd9-4015-9974-990d8f4e61b4
aa4b83ea-9bd9-4015-9974-990d8f4e61b4
TCGA-EJ-5502-01Z-00-DX1.9caa4792-06a2-431d-bec3-8b17f41453fe.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, where glands are discrete and well-formed while lacking the layer of basal cell.
3
https://data.codatta.io/79cb6370-59fa-47c0-88a8-3f5953dbac12
79cb6370-59fa-47c0-88a8-3f5953dbac12
TCGA-2A-AAYF-01Z-00-DX1.D0ADEB9A-37A4-451C-B91C-4AB014A6857A.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, where glands are discrete and well-formed while lacking the layer of basal cell.
1
https://data.codatta.io/7d71dc8e-8c6b-47ff-8ccc-c940a9bf1490
7d71dc8e-8c6b-47ff-8ccc-c940a9bf1490
TCGA-2A-A8VL-01Z-00-DX1.2C2BD6EF-EC17-4117-AE89-A22B67AFB233.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands that lacks the layer of basal cell. Minor Gleason Grade 4 tumor was found, where glands are fusing or missing lumen.
4
https://data.codatta.io/5de618ba-ec07-4661-a5d3-32143a074530
5de618ba-ec07-4661-a5d3-32143a074530
TCGA-EJ-5510-01Z-00-DX1.ab391b79-7b8f-4ad8-b5bd-c868effa75f8.svs
Gleason Score 4+3 with Minor 5
This slide contains predominantly Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structures. Minor Grade 5 tumor was also found, where glandular differentiation is absent.
2
https://data.codatta.io/588da864-d90c-4d80-86fa-b0cc9ece2e42
588da864-d90c-4d80-86fa-b0cc9ece2e42
TCGA-EJ-5517-01Z-00-DX1.7df66a54-404a-4b7d-a316-4ae6383c3afd.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside some Gleason Grade 4 tumor, characterized by glandular fusion.
2
https://data.codatta.io/62f367f9-6d6d-443b-afb2-cde807eeafe9
62f367f9-6d6d-443b-afb2-cde807eeafe9
TCGA-EJ-7784-01Z-00-DX1.9accc8f4-1b74-4e0f-8197-47a043c56dc0.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor near the top, characterized by glandular fusion or cribriform structure.
2
https://data.codatta.io/f3e3395e-7463-4ab8-a040-fffe791a57b5
f3e3395e-7463-4ab8-a040-fffe791a57b5
TCGA-KK-A59Y-01Z-00-DX1.0DB9AF4D-4879-4295-A321-CBEE0FE6B2A0.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by cribriform structure and glandular fusion, alongside Gleason Grade 3 tumor characterized by discrete gland. Minor Gleason Grade 5 tumor that lacks glandular differentiation was also found.
3
https://data.codatta.io/f4d3a4e0-65c9-4022-a39f-2901ccd11ced
f4d3a4e0-65c9-4022-a39f-2901ccd11ced
TCGA-V1-A9Z7-01Z-00-DX1.25193852-0015-4D15-A0EB-50DAA2F83686.svs
Gleason Score 4+5
The bottom side of the slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands. The top side of the slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion, and also Gleason Grade 5 tumor in denser area where glandular differentiation is absent.
2
https://data.codatta.io/8cf3978a-0dd4-4019-bf6c-a039387fd426
8cf3978a-0dd4-4019-bf6c-a039387fd426
TCGA-EJ-5519-01Z-00-DX1.5450fb44-4da5-44e3-bba1-52b978163469.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by cribriform structure. Some areas of the slide are Gleason Grade 5 tumor, characterized by closely packed nuclei and the absence of glandular differentiation.
2
https://data.codatta.io/fde30dbf-5b59-472b-b826-9c42e70b241c
fde30dbf-5b59-472b-b826-9c42e70b241c
TCGA-KK-A7B4-01Z-00-DX1.DAC07B4A-C8C5-4DFE-963A-502FB264E205.svs
Gleason Score 5+4
This slide contains predominantly Gleason Grade 5 tumor, characterized by the loss of glandular differentiation, with tumor cells forming solid sheets, irregular clusters, or single cells. Additionally, there are areas of Gleason Grade 4 and Grade 3 tumor observed near the center of the slide, where glandular differentiation is present.
4
https://data.codatta.io/acc12df5-78e2-4c4b-a7aa-f7adb065c056
acc12df5-78e2-4c4b-a7aa-f7adb065c056
TCGA-X4-A8KQ-01Z-00-DX1.A9466A6A-9474-4F93-88EB-D21CC1CCD47C.svs
Gleason Score 4+3
This slide contain predominately Gleason Grade 4 tumor, characterized by glandular fusion and the absence of luminal structures, alongside Gleason Grade 3 tumor where glands are discrete and well-formed.
1
https://data.codatta.io/bc158466-d0f8-48c9-986b-a43ee41048d3
bc158466-d0f8-48c9-986b-a43ee41048d3
TCGA-X4-A8KQ-01Z-00-DX3.31ACC93B-288F-4278-8C1D-D0BC3806CD44.svs
Gleason Score 4+3 with Minor 5
This slide contain predominately Gleason Grade 4 tumor, characterized by glandular fusion and the absence of luminal structures, alongside Gleason Grade 3 tumor where glands are discrete and well-formed. Additionally, minor Gleason Grade 5 tumor, characterized by scattered individual tumor nuclei lacking glandular differentiation.
2
https://data.codatta.io/9788bfe0-f860-4579-ac3f-be194015557c
9788bfe0-f860-4579-ac3f-be194015557c
TCGA-X4-A8KS-01Z-00-DX4.34C5D87E-7598-49A7-B937-6CD2D7D64811.svs
Gleason Score 3+3
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
1
https://data.codatta.io/26e7dced-7241-4591-8827-6fc5eca650ae
26e7dced-7241-4591-8827-6fc5eca650ae
TCGA-KK-A6E2-01Z-00-DX1.6FD46FC9-EE08-41C0-A11E-B4AEF7AA4B38.svs
Gleason Score 3+5
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Additionally, the denser area of the tumor is Gleason Grade 5, characterized by a complete absence of glandular differentiation.
3
https://data.codatta.io/48e3c5cf-2a8e-4993-b65c-106337013383
48e3c5cf-2a8e-4993-b65c-106337013383
TCGA-V1-A8MF-01Z-00-DX1.1216504B-8729-458D-A976-3C33DC34423E.svs
Gleason Score 4+3
The tissue in the middle contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands. The tissue on the top and bottom contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or the absence of lumen.
3
https://data.codatta.io/bb88dcbb-3468-40b9-8fe8-45ba00f7746f
bb88dcbb-3468-40b9-8fe8-45ba00f7746f
TCGA-QU-A6IO-01Z-00-DX1.9D16B516-872C-4916-A683-7A7C0CCC5176.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed Glands. Some areas where Gleason Grade 3 glands have fused are classified as Gleason Grade 4 due to the loss of glandular separation and the formation of irregular, fused structures.
2
https://data.codatta.io/5559ba78-47af-49bc-beb8-27692e781892
5559ba78-47af-49bc-beb8-27692e781892
TCGA-HC-8212-01Z-00-DX1.d63209dd-5d1b-4362-aa86-f676123bc22a.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure, alongside some Gleason Grade 3 tumor where glands are still discrete and well-formed.
3
https://data.codatta.io/7f5333c9-6ec4-4f38-9622-345a74b93afb
7f5333c9-6ec4-4f38-9622-345a74b93afb
TCGA-HC-7209-01Z-00-DX1.ccf1d3c8-0351-4b7e-8539-0817ce3b8364.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed gland, alongside Gleason Grade 4 tumor, which exhibit glandular fusion and loss of luminal structures.
2
https://data.codatta.io/1b87f2f3-1710-456a-9835-590feadf546e
1b87f2f3-1710-456a-9835-590feadf546e
TCGA-G9-6336-01Z-00-DX1.ec538aa0-4ecf-412c-9a5f-4babd4201307.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well formed glands. There is also minor Gleason Grade 4 tumor, which exhibit glandular fusion and cribriform architecture.
4
https://data.codatta.io/9ec44dab-9479-46c0-9b5e-e3e620f7e51d
9ec44dab-9479-46c0-9b5e-e3e620f7e51d
TCGA-2A-A8W3-01Z-00-DX1.CC00522F-8A47-4C63-B9CC-F215F9EAAFBA.svs
Gleason Score 4+4 with Minor 5
This slide contain predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure, alongside Gleason Grade 3 tumor on the right side of the slide, characterized by discrete glands. Minor Gleason Grade 5 tumor was also observed, identified by the absence of glandular differentiation.
3
https://data.codatta.io/913a22b8-2566-45bf-886e-46861f12deab
913a22b8-2566-45bf-886e-46861f12deab
TCGA-XJ-A9DQ-01Z-00-DX1.8B133659-B177-4D12-A81E-4EDDACB3D05B.svs
Gleason Score 3+4
This slide contains mostly Gleason Grade 3 tumor, characterized by discrete and well-formed glands, alongside Gleason Grade 4 glands, characterized by glandular fusion and cribriform structure.
3
https://data.codatta.io/a500ee1e-af83-40d2-9e36-35c39afcfbec
a500ee1e-af83-40d2-9e36-35c39afcfbec
TCGA-HC-7075-01Z-00-DX1.38ecaf2d-62ed-4d1c-8e88-0e757cffe77c.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-form glands, alongside minor Gleason Grade 4 tumor, which exhibits glandular fusion.
2
https://data.codatta.io/62a95c2f-e40a-45af-9f10-3313dc90fd53
62a95c2f-e40a-45af-9f10-3313dc90fd53
TCGA-XA-A8JR-01Z-00-DX1.E31C544F-F56B-4331-8024-132BB6FA11E2.svs
Gleason Score 3+3
This slide contains benign atrophic glands, characterized by reduced gland size and cytoplasmic volume, alongside Gleason Grade 3 glands, which exhibit dense intraluminal secretions and well-formed, discrete architecture.
4
https://data.codatta.io/4055456b-0ac2-4962-82a8-d0a684e89b39
4055456b-0ac2-4962-82a8-d0a684e89b39
TCGA-HC-A76W-01Z-00-DX1.A39A1BAD-9D0E-4818-8EFC-1ED5C4891E29.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor that has minimal glandular differentiation, alongside scattered Gleason Grade 5 tumor that lost glandular differentiation completely.
1
https://data.codatta.io/7cf6f52c-6488-4ba0-b2b8-fa1664de74f2
7cf6f52c-6488-4ba0-b2b8-fa1664de74f2
TCGA-KK-A59X-01Z-00-DX1.8F30C2E2-BBA2-4857-B020-E548C4D7C359.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure, alongside Gleason Grade 5 tumor in some area, which lost glandular differentiation.
3
https://data.codatta.io/0138c086-0d7e-4fce-a1e9-8c272173e5b1
0138c086-0d7e-4fce-a1e9-8c272173e5b1
TCGA-HI-7170-01Z-00-DX1.a823f5e3-3285-4fa5-846e-aaa0d0ac0698.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 glands, characterized by discrete and well-formed glands, alongside Gleason Grade 4 glands that exhibit glandular fusion
2
https://data.codatta.io/70ecd528-a5c8-45ab-8b75-32137fc59367
70ecd528-a5c8-45ab-8b75-32137fc59367
TCGA-M7-A721-01Z-00-DX1.DB6F590D-95C4-4FA1-8476-944D21EEB65D.svs
Gleason Score 3+4 with Minor 5
This slide contains predominately Gleason Grade 3 tumor, characterized by discrete and well-formed glands that lack basal cell layer, alongside Gleason Grade 4 tumor, characterized by glandular fusion and the absence of lumen. Minor Gleason Grade 5 tumor was also observed on the left side of the tumor, identified by loss of glandular differentiation.
2
https://data.codatta.io/91efd4cf-e8f0-4f53-8b60-c9a79fa09745
91efd4cf-e8f0-4f53-8b60-c9a79fa09745
TCGA-HC-7745-01Z-00-DX1.50e87666-fdf5-4a68-a679-6fb3c770513e.svs
Gleason Score 3+4
This slide contains predominately Gleason Grade 3 glands, characterized by discrete and well-formed glands, alongside Gleason Grade 4 tumor which exhibit glandular fusion and loss of luminal structure.
1
https://data.codatta.io/3f6995e8-fd89-483f-807f-4e03318a5e4d
3f6995e8-fd89-483f-807f-4e03318a5e4d
TCGA-G9-6365-01Z-00-DX1.58e1ed37-d7bb-4f41-b5a1-ad92af2b0ac8.svs
Gleason Score 3+3 with Minor 4
This slide contains predominately Gleason Grade 3 tumor, characterized by well formed and well separated glands, alongside minor Gleason Grade 4 glands which exhibit glandular fusion, or cribriform structure, or loss of lumen.
3
https://data.codatta.io/c04ebd48-8a9b-44b0-bce1-725f4c0aae5f
c04ebd48-8a9b-44b0-bce1-725f4c0aae5f
TCGA-V1-A8ML-01Z-00-DX1.BEE27AFB-3331-464F-BB9D-69C1AE1865CA.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or loss of lumen, alongside Gleason Grade 3 tumor where glands are discrete and well-formed. More Grade 4 than Grade 3, because the Grade 3+4 regions has lots of Grade 4 too.
3
https://data.codatta.io/82e12aab-10c2-4205-875c-5a206c4c9cde
82e12aab-10c2-4205-875c-5a206c4c9cde
TCGA-HC-7738-01Z-00-DX1.CB18FC7E-9960-4639-9D95-B1EA15D1E8E1.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands.
3
https://data.codatta.io/d32ab88a-b591-4f2c-a48e-1cc2ea37344c
d32ab88a-b591-4f2c-a48e-1cc2ea37344c
TCGA-V1-A9OY-01Z-00-DX1.95F6F791-F14D-4C88-8343-F0375D89D140.svs
Gleason Score 4+5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and loss of lumen. There is significant amount of Gleason Grade 5 tumor, characterized by loss of glandular differentiation. This slide demonstrates a significant presence of Gleason Grade 5 tumor. In areas with numerous Grade 3 glands, scattered Grade 5 nuclei can be observed interspersed among the Grade 3 glands.
1
https://data.codatta.io/7ab7078a-2209-4f98-a236-14f1fef17150
7ab7078a-2209-4f98-a236-14f1fef17150
TCGA-HC-7210-01Z-00-DX1.07b41e7b-3097-4a56-a8db-249b9fb0553b.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 glands, characterized by glandular fusion and cribriform structure, alongside Gleason Grade 3 tumor characterized by discrete glands that lacks the layer of basal cell.
1
https://data.codatta.io/7b6c2f87-67dc-4237-9c5a-fc95f9d972b9
7b6c2f87-67dc-4237-9c5a-fc95f9d972b9
TCGA-HC-A6AS-01Z-00-DX1.1E5AB965-7B24-4C19-BFEA-91FF7D08DD1D.svs
Benign
This slide contains benign glands, characterized by the presence of basal cell layer.
1
https://data.codatta.io/6073885a-d340-4842-8311-9baac72414b4
6073885a-d340-4842-8311-9baac72414b4
TCGA-KK-A8I6-01Z-00-DX1.C81CEF74-FDE6-4D01-BA09-AEF6F9C6A3D7.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete gland and lack of basal cell layer. Minor Gleason Grade 5 tumor is also present, appearing either as cord-like structures or as scattered individual tumor nuclei, both lacking glandular differentiation.
2
https://data.codatta.io/4ab1dd75-d83e-4bd5-a6ab-a364e9ebad42
4ab1dd75-d83e-4bd5-a6ab-a364e9ebad42
TCGA-V1-A9OH-01Z-00-DX1.E4CD8354-A5F2-4582-9CED-F81F3AB6BD75.svs
Gleason Score 5+3
This slide contains predominately Gleason Grade 5 tumor near the bottom, characterized by the absence of glandular differentiation, alongside Gleason Grade 3 tumor near the top, characterized by discrete and well-formed glands that lacks a layer of basal cell.
2
https://data.codatta.io/c46eccf2-6802-4858-8cfd-8a78bb51e091
c46eccf2-6802-4858-8cfd-8a78bb51e091
TCGA-TP-A8TV-01Z-00-DX1.16CEB4D6-1E14-4211-A9E8-D94EA0FBC2EE.svs
Gleason Score 4+3 with Minor 5
This slide contains predominately Gleason Grade 4 tumor, characterized by fused glands or cribriform structure, alongside Gleason Grade 3 tumor, characterized by discrete and well-formed glands. Minor Gleason Grade 5 tumor was also found near the top of the slide, mixed with Gleason Grade 4 tumor, identified by absence of glandular differentiation.
2
https://data.codatta.io/b8c468ef-48ae-4abd-8590-2c25233c08a7
b8c468ef-48ae-4abd-8590-2c25233c08a7
TCGA-H9-A6BY-01Z-00-DX1.304BEB19-3F0A-4676-B077-A4650F5C84A5.svs
Gleason Score 4+3
The tissue on the left demonstrates a higher proportion of Gleason Grade 4 tumor, characterized by glandular fusion and loss of luminal structures, while the tissue on the right contains predominantly Gleason Grade 3 tumor with well-formed, discrete glands. Overall, Gleason Grade 4 tumor is more prevalent across both tissues.
2
https://data.codatta.io/99906aa4-c049-4ddc-8a22-ac6d37f66fdb
99906aa4-c049-4ddc-8a22-ac6d37f66fdb
TCGA-XK-AAJP-01Z-00-DX1.D61D88E0-5514-46C0-A197-8DC04A47A82D.svs
Gleason Score 4+4
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure.
1
https://data.codatta.io/12ae7e62-184d-4b6a-832b-48c38d3a0010
12ae7e62-184d-4b6a-832b-48c38d3a0010
TCGA-J4-AATZ-01Z-00-DX1.E9BDB060-C38C-4315-B1CE-FB23FA2DEE8D.svs
Gleason Score 4+3
This slide contains predominately Gleason Grade 4 tumor, characterized by glandular fusion and cribriform structure, alongside Gleason Grade 3 tumor, which exhibit discrete and well-formed glands.
1

Note: Our 245 TCGA cases are ones we identified as having potential for improvement. We plan to upload them in two phases: the first batch of 138 cases, and the second batch of 107 cases in the quality review pipeline, we plan to upload them around early of January, 2025.

Dataset: A Second Opinion on TCGA PRAD Prostate Dataset Labels with ROI-Level Annotations

Overview

Exmaple of Annotated WSI This dataset provides enhanced Gleason grading annotations for the TCGA PRAD prostate cancer dataset, supported by Region of Interest (ROI)-level spatial annotations. Developed in collaboration with Codatta and DPath.ai, where DPath.ai launched a dedicated community via Codatta to assemble a network of pathologists, this dataset improved accuracies and granularity of information in the original TCGA-PRAD slide-level labels. The collaborative effort enabled pathologists worldwide to contribute annotations, improving label reliability for AI model training and advancing pathology research. Unlike traditional labeling marketplaces, collaborators a.k.a pathologists retain ownership of the dataset, ensuring their contributions remain recognized, potentially rewarded and valuable within the community. Please cite the dataset in any publication or work to acknowledge the collaborative efforts of Codatta, DPath.ai, and the contributing pathologists.

Motivation

We discovered significant opportunities for data improvement in the diagnostic labels of the TCGA PRAD dataset, where:

  • Some labels could be enhanced with additional diagnostic labels a.k.a opinions.
  • Some labels lacked granular descriptions of the Gleason patterns.

This presents a challenge for AI pathology models, as reported high accuracy might reflect learning from improved labels. To address this:

  • Pathologists re-annotated slides to improve label quality.
  • ROI annotations were introduced to clearly differentiate Gleason tumor grades.
  • Each annotation is supported by detailed reasoning, providing transparency and justification for corrections.

Dataset Contents

This dataset includes two primary files:

  1. Slide-Level Labels (PRAD.csv)

    • Contains comprehensive metadata and diagnostic details:
      • data_profile_uri: A URI that links to Codatta's web application, offering a detailed view of the slide's metadata and its associated data lineage.
      • slide_id: Unique slide identifier.
      • slide_name: TCGA Whole Slide Image (WSI) name.
      • label: Corrected Gleason grade (e.g., 4+3, 5+4).
      • diagnosis: Pathologist-provided reasoning for the label.
      • num_rois: Number of labeled Regions of Interest (ROIs) per slide.
  2. ROI-Level Annotations (.geojson)

    • Provides spatial coordinates for tumor regions:
      • Each ROI corresponds to specific Gleason grades (e.g., Grade 3, Grade 4).
      • Compatible with tools like QuPath for interactive visualization.

Key Statistics

Type Counts
TCGA WSI Total 435
Agree with TCGA's label 190
Refined label and ROI 245

We are currently in the process of uploading data files to meet the quantities mentioned above. This is an ongoing effort to balance community impact and data quality.

Re-Annotation and Labeling Process

workflow of re-annotation and labelingt

  1. Curation of Cases for Enhancement: An expert committee identified slides requiring review.
  2. Annotation: Junior pathologists performed initial ROI-level annotations.
  3. Expert Review: Senior pathologists validated and refined the annotations.
  4. Enhancements:
    • Granular ROI labeling for tumor regions.
    • GIntroduction of Minor Grades: For example, Minor Grade 5 indicates <5% of Gleason Grade 5 tumor presence.
    • GPathologist Reasoning: Each label includes a detailed explanation of the annotation process. Some labels can be improved by adding alternative opinions to enhance the labels further.

Improvements Over TCGA Labels

  • Accuracy: Enhanced slide-level Gleason labels with additional opinions and improved granularity.
  • Granularity: Clear ROI-level annotations for primary, secondary, and minor tumor grades.
  • Transparency: Pathologist-provided reasoning ensures a chain of thought for label decisions.

Example:

  • Original TCGA label: Gleason Grade 4+3.
  • Enhanced label: Gleason Grade 4+3 + Minor Grade 5.

Usage

For AI Training Pipelines

Combine Whole Slide Images (WSI) from TCGA PRAD with this dataset's slide-level labels (PRAD.csv) and ROI annotations (.geojson) to generate high-quality [X, y] pairs.

For Pathology Research

Use the ROI annotations in Whole Slide Images (WSIs) to interactively visualize labeled tumor regions. The slides can be viewed through Codatta's data profile (e.g., https://data.codatta.io/[slide_id]) or other compatible viewers like QuPath. Additionally, explore detailed reasoning behind Gleason grade decisions to gain insights into tumor composition.

How to Load the Dataset

  1. CSV File Use pandas to explore slide-level metadata:
import pandas as pd
df = pd.read_csv("PRAD.csv")
print(df.head())
  1. GeoJSON File Load ROIs using tools like QuPath or GeoPandas:
import geopandas as gpd
roi_data = gpd.read_file("annotations.geojson")
roi_data.plot()
  1. TCGA Whole Slide Images Original WSI files can be downloaded from the GDC Portal. Match WSI filenames with the slide_name column in PRAD.csv for integration.

Example Steps

  1. Download TCGA PRAD slides from the GDC Portal.
  2. Load PRAD.csv to access corrected labels and reasoning.
  3. Visualize ROI annotations using the .geojson files.
  4. Train AI models with X = WSI images, y = ROI annotations + slide-level labels.

Licensing

This dataset is licensed under OpenRAIL-M for non-commercial use. Commercial use requires obtaining a separate license. Please contact [email protected] for licensing inquiries.

Credits

This dataset is a collaboration between:

  • Codatta: A platform that brings together a community of anonymous pathologists to collaborate on annotation and labeling tasks.
  • DPath.ai: The initiator of the project, responsible for defining the task scope, data requirements, quality assurance workflows, and recruiting the initial cohort of expert pathologists.

Contact

For questions, suggestions, or collaborations (launch custom data sourcing and labeling tasks), please reach out via:

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