Question: I'm moving some files around on the server (Windows Server 2003), and there's a locked file that no one seems to have open. How do I delete this file?

Answer: 
SysInternals has a tool called MoveFile that will do move or delete the file upon reboot of the machine.

[MoveFile link](http://technet.microsoft.com/en-us/sysinternals/bb897556.aspx)
As a last resort you can try booting up in "Safe Mode" or "Command Prompt" mode and deleting the file that way.

We see this a lot with viruses, spyware, etc. Booting up in safe mode usually does the trick.

Good luck!