Question: So this question is **not** about having num lock on by default.

Is it possible to have num lock turned on, and remove the ability of the num lock button on the keyboard to affect that state?

### EDIT (because):

In my keyboard the `Home` button is really close to the `numlock`. At work I often use `Home` and the numpad, but sometimes I accidentally hit the `numlock` too. As a result my numpad gets turned off which is really sucks when I have to type a lot of numbers and after a while I realise I typed nothing because numlock turned off numpad.

Answer: 
Physically remove the NumLock key. When your finger goes to press it, it won't be there.
Maybe not the answer you are looking for, but it solved that problem for me:

Activate the sound for the Lock keys in Windows (in Windows 10: Control Panel\Ease of Access\Ease of Access Center\Make the keyboard easier to use\Turn on Toggle keys)

That way, when you hit it, it beeps, and you realize it right away. It actually trained me to not hit it anymore at all, because the signal is right when it happens.