Question: I've been wanting to post on this for some time, but don't want to post something just to have it shut down as a duplicate because it talks about disabilities and someone else has already posted about disabilities.

Autism Spectrum has some fairly unique problems specific to the workplace that other disabilities do not, because we seem relatively normal, especially on the high end, but our communication skills and behaviors can cause trouble for us. In short, we can come across as jerks when we don't intend to, and that's something that other disabilities don't have to face. You don't consider someone who is deaf to be rude for not hearing you for example.

I would like to pose a question or two asking for advice on how to deal with AS in the workplace, but would like to ensure it's on topic. What is the best way to do so?

Answer: 
Just post the question(s), either we can deal with them or we can't. But there's a host of keen, intelligent and observant people here with a lot of experience in all sorts of things, I reckon someone will be able to answer you.

Just not me, because I never even heard of it before coming here except some maths wizard guy in a movie. Who I would hire like a shot and treat like he's made of gold.
Handling disabilities on workplace is a real matter nowadays, they're laws to enforce that they're provided an adequate environment to work and to not get discriminated. So I can't see why this won't be on-topic as long as it is related to problems that affect the workplace.

However I guess that in some specific issues you might have an hard time to get an answer, because not a lof of people on the site will know how exactly to deal with, possibly neither your manager or a RH.

Finnaly some people here could ask questions about a coworker being rude when they don't know he's in the AS either because he's didn't check it with a doctor or he won't reveal it. This is probably the hardest part about it. Probably the best answer there would be just for peoples to try to figure out if he meant to be jerk or if he's just like this "naturally", which can be a problem when this look like unprofessional. Having differents answer for two apparent similar problems, when one is caused by an (possibly not known) AS and one is not is really tricky.