Question: I have a moveable and closable jquery pop-up notification box. It works well aside from the fact that it pops up every time the page is loaded. What method would I need to implement to allow a user to permanently (or at least semi permanently) close the pop-up box?

If I need to use cookies how would I tie a cookie to a specific action like closing the div?

Answer: 
yes you can use cookies. when user click on the close button you can write it to the cookies. and when page load, if cookie is not available display the popup
session would be another candidate and its secure than cookies. And you don't have to do anything else than setting a variable on loading popup on first time and check afterwards if that variable is set or not.