Question: I have a moveable and closable jquery pop-up notification box. It works well aside from the fact that it pops up every time the page is loaded. What method would I need to implement to allow a user to permanently (or at least semi permanently) close the pop-up box?

If I need to use cookies how would I tie a cookie to a specific action like closing the div?

Answer: 
yes you can use cookies. when user click on the close button you can write it to the cookies. and when page load, if cookie is not available display the popup
Yes you can use cookies to do the trick, basically you're checking to see if the variable in the cookie is set, if not update the variable:

<http://www.w3schools.com/js/js_cookies.asp>

Don't forget that on close, you should update the cookie variable.