Question: There doesn't seem to be any difference between how [bioinformatics](https://biology.stackexchange.com/questions/tagged/bioinformatics "show questions tagged 'bioinformatics'") and [computational-biology](https://biology.stackexchange.com/questions/tagged/computational-biology "show questions tagged 'computational-biology'") are used, I would propose to merge those tags.

* Is there any argument against this?
* Which one should be the main tag?

Answer: 
I'm in favor of merging them. There is no single definition for either, nor a clear delineation between them. Compared to other areas of biology their overlap is so large that the tags should be merged. 

I'm less sure about the main tag, but I guess bioinformatics is more popular (and succinct).
Both "bioinformatics" and "computational-biology" are different as aptly answered here:
[Is "computational biology" different from "bioinformatics"?](https://biology.stackexchange.com/questions/3192/how-computational-biology-differs-from-bioinformatics-or-does-it#comment4783_3192)