Question: For some reason I am getting a "Cannot initialize ActiveScript" error when I try to run tsc. Any ideas how to fix it?

I did read the other question in here, but I am already running IE11, så installing IE10 does not sound like a solution. Also I am not looking for the workaround of running it through node.

Answer: 
I know this is an older issue but I had the same issue a few weeks back.
In my case there where two version in the following directory (0.9 and 1.0): C:\Program Files (x86)\Microsoft SDKs\TypeScript#

I resolved it by removing the older version and everything started working again!
I started to get this error when I accidentally deleted tschost.dll, which had been next to tsc.exe (we are way back on version 1.6.2, lucky us.) Replacing tschost.dll corrected the error.