Question: Can "[antithesis](http://www.ldoceonline.com/dictionary/antithesis)" be used with the preposition "to" as in the following example sentence?

> 
> ...We human beings have a tendency to demand without giving much in
>  return to the Earth. However, this is an antithesis **to** how the
>  biosphere works...
> 
> 
>

Answer: 
Your use of "to" is correct. However, one would take issue with your use of the article, 'an'.

The word 'antithesis' is to mean the *exact* opposite of something. Meaning, there can be only one exact opposite. So if you're going to use antithesis in a sentence, it should be written as '**the** antithesis' rather than '**an** antithesis', as there shouldn't exist more than one antithesis.
Why not replace the noun with an adjective, which seems much more natural to me?

> 
> ...We human beings have a tendency to demand without giving much in return to the Earth. However, this is *antithetical* to how the biosphere works...
> 
> 
>