Question: we have a partial html:

```
<ul>
    <li class="class1">AFFECTED</li>
    <li class="class1 class2">NOT</li>
    <li class="class1">NOT</li>
</ul>

<ul>
    <li class="class1 class2">NOT</li>
    <li class="class1">AFFECTED</li>
    <li class="class1">NOT</li>
</ul>

<ul>
    <li>NOT</li>  
    <li class="class1">AFFECTED</li>
    <li class="class1">NOT</li>
</ul>

```

I need a ***universal* css-selector** for the first li's of any list with only class1.

* li's with extra classes (class2) MUST NOT be affected.
* only first li with class1 should be selected (to change the
appearance of A.
* no JS/jQuery.
* li's are float, so no hard coded nth-child.
* code is generated automatically, so no way add/remove custom classes.

I've tried to use :not(class2), [class2] :first-child & :first-of-type but with no avail.

Thanks!

Solution: <http://jsfiddle.net/6hxZa/3/>

Answer: 
If you want to specifically exclude `class2` from the selector, use: 

```
li.class1:first-child:not(.class2) { }

```

If you want to exclude any additional classes other than `class1` use:

```
li[class=class1]:first-child { }

```

I would recommend the first if you know which class(es) you're excluding as it will interfere less with other/future styles.

jsFiddle of #1: <http://jsfiddle.net/Cmypc/>
jsFiddle of #2: <http://jsfiddle.net/Cmypc/1/>

**EDIT** If you're looking for a `:first-of-class` selector, there isn't one (see [this thread](https://stackoverflow.com/questions/2717480/css-selector-for-first-element-with-class)). A future solution may be the `:nth-match` selector but you'll have to wait for CSS4. Alternatively, you can use a more elaborate clearing selector to undo the styles applied (see BoltClock's answer) as a workaround.
Try this

```
li:first-child
{
...
}

```

this is only for class 1

```
li.class1:first-child
{
color:#ff0000;
}

```

and here is a [fiddle](http://jsfiddle.net/x7Ezh/)

and if you dont want the list with class2 to be affected 
maybe this can work for you

```
    li.class1.class2:first-child
    {
        ...
        code that will reset
    }

```