Question: I have a page I have to update, it has 3 frames (top bar, side bar and main content. If i click something in the main content frame i want to update a list in the side bar frame. how do i do this (i use jquery or javascript for button clicks).

Answer: 
Trying to state the answers above more precisely (and correct some parts)...

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> *multiplexing allows to reduce overhead of creating new connections to FCGI clients effectively interweaving requests chunks*
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In opposite to keep-alive it reduces new connections drastically, especially on high-load servers or if micro-servicing (a lot of micro requests) in usage. Futhermore it is almost required in case of balancing across network (so one cannot use unix-sockets anymore and the connection buildup process gaining more and more priority).

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> *and at the same time enabling "keep-alive" model to connection*
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Although the multiplexing is not required for keep-alive, but keep-alive is almost required for multiplexing (otherwise it would make little sense).

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> *I've found there's no server that implements FCGI multiplexing*
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There is few servers that supports multiplexing out of the box, but...  

I saw already several modules of other devs and I have own fcgi-module for nginx (as replacement) that supports FastCGI multiplex requests.
It can show the real performance increase in the practice, especially if the upstreams are connected over the network.
If someone needs it, I will try to find time and make it available on github etc.

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> [*from answer above*] FastCGI multiplexing is generally a bad idea, because FastCGI doesn't support flow control. That means: If a FastCGI backend sends data, but the http client can't receive data fast enough, the web server has to save all those data, until they can be sent to the client.
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This is not true. Normally the FastCGI handlers are fully asynchronous, pool of workers is separated from the delivering workers, etc.
So each chunk gets a request-id, so if two or more upstream workers write to single connection simultaneously, the chunks that nginx will get are just smaller. That is the single cons.
As regards the "the web server has to save all those data", it does this in any case (regardless multiplexing used or not), because otherwise one can get out-of-memory situation if too many pending data available for response. So either the backend should produce fewer data (or be thwarted) or the web-server should receive it as soon as possible and transmit it to client or save it to some interim storage (and for example nginx does this if pending data size exceeds the values configured with *fastcgi\_buffer\_size* and *fastcgi\_buffers* directives).

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> [*from answer above*] When using multiplexing the web server needs to read all data from the fastcgi backend, even though one of the clients isn't receiving data fast enough.
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Also this is false. The web-server has to read only the single chunk of response to the end, and good worker pools have "intelligent" handling, so automatically sends the chunks to the web-server as soon as possible (means if it gets available), so if multiple content-providers write to so-called "reflected" channels of the same real connection, the pending packets will be separated and chunks received from nginx as soon as the response data is available.
Thereby almost only the throughput of the connection is crucial, and it does not matter at all how fast the clients will receive the data.
And again, multiplexing saves vastly the time of the connection buildup, so reduces number of pending requests as well as the common request execution time (transaction rate).
I don't know if some server implement FASTCGI multiplexing (which I believe you understood correctly, but the details are in the FASTCTI protocol specifications), and I would not bother.

You will very probably use FASTCGI thru an [existing FASTCGI library](http://www.fastcgi.com/drupal/node/5) (e.g. [Ocamlnet](http://projects.camlcity.org/projects/ocamlnet.html) if you code in Ocaml, etc.). And that library would do the multiplexing, if it does it. From your point of view (of that library user) you should not really care, unless you are coding such a library yourself.

If FASTCGI multiplexing bothers you, you might use the [SCGI](http://en.wikipedia.org/wiki/Simple_Common_Gateway_Interface) protocol, which offers similar functionality, but is simpler, a bit less efficient, and non-multiplexing.