Question: I purchased a Prius many years ago, but many of my friends have put forth claims that the batteries are very toxic and thus I may in fact be creating more harm than good in using a hybrid and that hybrid's are a less sustainable solution than non-hybrids?

How can one objectively measure the total footprint of a hybrid vehicle to determine whether the use of a hybrid over a traditional non-hybrid gasoline powered vehicle is lesser or greater? Has much research gone into the entire picture? For example, when the car reaches the end of its useful life, what happens to the batteries, can they be recycled or are they thrown away? What about the manufacture of the batteries, what negative effects come into play during manufacture? Are there other externalities that I've missed?

Answer: 
I find the site [CarbonCounter.com](http://carboncounter.com), developed by MIT, useful in approaching this question. You can play around with some of the assumptions on e.g electricity supply, battery manufacture emissions and vehicle lifetime. Under most reasonable assumptions, for vehicles of comparable size, hybrids are better than pure ICE, and EVs better than hybrids (unless the electricity is mainly coal). So while yes 'it depends', after playing with the options for a bit, a rough rule of thumb for US average electricity is that hybrids are around 2/3 the lifecycle co2 of an ICE, and full electric are around 50% lifecycle co2 of an ICE. (Very roughly)
In this case [Life Cycle Assessment](https://www.thinkstep.com/life-cycle-assessment) is indeed the way to go. A Life Cycle Assessment is the systematic analysis of the environmental impact of a product during its entire life cycle. So to determine whether hybrid cars are more sustainable than traditional cars, one would have to collect and assess all inputs and outputs during the entire life cycle of a hybrid car.