Question: There doesn't seem to be any difference between how [bioinformatics](https://biology.stackexchange.com/questions/tagged/bioinformatics "show questions tagged 'bioinformatics'") and [computational-biology](https://biology.stackexchange.com/questions/tagged/computational-biology "show questions tagged 'computational-biology'") are used, I would propose to merge those tags.

* Is there any argument against this?
* Which one should be the main tag?

Answer: 
I guess there isn't much point to comment on status-complete, but for posterity I disagree with this decision.

Bioinformatics and computational-biology have distinct communities, there is a lot of overlap but there are many researchers whould identify with only one of those groups. The arguments given in the other answers of "there hasn't been a distinguishing question, yet" is not a valid one. From the little I've read of bio.SE there are almost no mathematical or computational questions in general. You should not judge on the criteria of existing questions as much as on the criteria of possible future questions.

For instance, I recently asked a question:

[Computational/mathematical models for predicting phenotype from genotype](https://biology.stackexchange.com/q/2982/500)

Which I think fits under computational-biology, but in my opinion definitely does not fit under bioinformatics. Since the tags have been synonymized and I didn't want bioinfo as a tag, I could not tag this question as computational. But I did find other tags (like mathematical-models; although I maybe should have created a computational-models tag) that worked.
Both "bioinformatics" and "computational-biology" are different as aptly answered here:
[Is "computational biology" different from "bioinformatics"?](https://biology.stackexchange.com/questions/3192/how-computational-biology-differs-from-bioinformatics-or-does-it#comment4783_3192)