Question: Whenever I run `sudo rm -rf /Applications/iTunes.app`, it is deleted, but after some time it's automatically restored. How can I get rid of iTunes forever without any chance of it coming back?

Answer: 
If you just want to prevent it from launching, running

```
sudo chmod 000 /Applications/iTunes.app

```

should do the trick. Needs to be repeated after every OS X/iTunes update, but this also applies for any solutions involving removal of standard applications.

PS: Just to put things into perspective as far as disk space is concerned:

```
root@Mithos:/Applications$ du -sm iTunes.app Chess.app Game\ Center.app Stickies.app Photo\ Booth.app Photos.app 
191 iTunes.app
5   Chess.app
3   Game Center.app
5   Stickies.app
5   Photo Booth.app
31  Photos.app

```

Even on a system with just a 128 GB SSD, squeezing out 200 MB doesn't give you much.
Uninstalling iTunes is not supported by Apple. Dragging it into the trash and trying to delete the trash will give you a "iTunes can't be modified or deleted because it's required by OS X" message.

Even if you do it manually, it will come back with operating system updates; and you may break certain things like some file associations and iPhone connecting/syncing abilities.

Your best bet is probably just to let it sit there and ignore it.