Question: Is it possible to get an 'S' rank in Resident Evil 6? If so, what are the general requirements? I know some will probably be subjective to the level (time and enemies) but what about accuracy and deaths? is there a set rule for an 'S' rank? (assuming it is even possible)

This was the case in most of previous games. So far my best is an A rank, and I suppose the closest I have to knowing if an 'S' rank is possible is that my number of deaths was at 1 (which gave me an 'A' rank) and I wonder if 0 deaths would be an 'S' rank.

Anybody got anything better than an A?

Answer: 
While I do not own the game, someone took the time to upload a set of videos where they play through chapter 1 on professional (so they have a bunch of things unlocked, making everything much easier).

If you look at [these](http://www.youtube.com/watch?v=2nGwPZpcCmU) [three](http://www.youtube.com/watch?v=XZLkjhXphkk) [videos](http://www.youtube.com/watch?v=j8JUn4dVN8g), you can see them attain an S rank on that chapter, with relevant tips.

The important bit, though, is probably this:
![Criteria?](https://i.stack.imgur.com/rutI5.jpg)

While the above aren't necessarily the minimum criteria for an S rank, you will definitely attain one if you are at least that good (on that specific chapter, it obviously makes sense that the criteria are different for different chapters).
I don't think the time matters that much. The most important factors are how many enemies are killed and especially the accuracy; how well you aim at the enemies. You shouldn't do "straight bullet"... missing shots will definitely decrease your chance to get an "S". Try to kill them with no misses; critical hits are good, but the upper body is better for a novice!