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<title>GLP-1 Proteína: La Hormona Clave en el Metabolismo</title>
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<span class="text-xl font-bold text-indigo-600">GLP-1</span>
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<span class="block">GLP-1</span>
<span class="block text-2xl md:text-3xl font-medium mt-2">Péptido Similar al Glucagón 1</span>
</h1>
<p class="mt-6 max-w-lg mx-auto text-lg md:text-xl">
La hormona incretina clave en el metabolismo de la glucosa y el control del apetito.
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<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Datos clave</h2>
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
¿Qué es GLP-1?
</p>
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
El péptido similar al glucagón 1 (GLP-1) es una incretina producida en el intestino que juega un papel crucial en el metabolismo.
</p>
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<h3 class="text-lg font-medium text-gray-900 mb-2">Hormona intestinal</h3>
<p class="text-gray-500">
Secretada por las células L del intestino en respuesta a la ingestión de alimentos.
</p>
</div>
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<h3 class="text-lg font-medium text-gray-900 mb-2">Vida media corta</h3>
<p class="text-gray-500">
Degradada rápidamente por la enzima DPP-4 con una vida media de solo 1-2 minutos.
</p>
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<h3 class="text-lg font-medium text-gray-900 mb-2">Acciones múltiples</h3>
<p class="text-gray-500">
Actúa sobre páncreas, cerebro, estómago, hígado y sistema cardiovascular.
</p>
</div>
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<i class="fas fa-pills"></i>
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<h3 class="text-lg font-medium text-gray-900 mb-2">Blanco terapéutico</h3>
<p class="text-gray-500">
Base para fármacos contra diabetes tipo 2 y obesidad como exenatida y liraglutida.
</p>
</div>
</div>
</div>
</div>
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<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Roles fisiológicos</h2>
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
Funciones clave de GLP-1
</p>
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
El GLP-1 ejerce múltiples efectos en diferentes órganos del cuerpo humano.
</p>
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<!-- Function 1 -->
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<h3 class="text-lg font-medium text-gray-900">Páncreas</h3>
</div>
</div>
<div class="mt-4">
<p class="text-gray-600">
- Estimula la secreción de insulina dependiente de glucosa<br>
- Inhibe la liberación de glucagón<br>
- Promueve la proliferación de células β<br>
- Reduce la apoptosis de células β
</p>
</div>
</div>
</div>
<!-- Function 2 -->
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<h3 class="text-lg font-medium text-gray-900">Sistema nervioso</h3>
</div>
</div>
<div class="mt-4">
<p class="text-gray-600">
- Suprime el apetito al actuar sobre núcleos hipotalámicos<br>
- Induce saciedad<br>
- Regula preferencias alimentarias<br>
- Reducel consumo de alimentos
</p>
</div>
</div>
</div>
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<h3 class="text-lg font-medium text-gray-900">Tracto gastrointestinal</h3>
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<p class="text-gray-600">
- Retrasa el vaciamiento gástrico<br>
- Reduce la motilidad intestinal<br>
- Disminuye la absorción de nutrientes<br>
- Puede tener efectos protectores sobre la mucosa
</p>
</div>
</div>
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<h3 class="text-lg font-medium text-gray-900">Sistema cardiovascular</h3>
</div>
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<p class="text-gray-600">
- Mejora la función endotelial<br>
- Efectos cardioprotectores<br>
- Reduce la presión arterial<br>
- Disminuye la inflamación vascular
</p>
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</div>
</div>
</div>
</div>
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Investigación sobre GLP-1
</p>
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
Descubrimientos recientes y direcciones futuras de investigación.
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<h3 class="text-lg font-medium text-indigo-600 mb-4">Mecanismos de acción</h3>
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<p class="ml-3 text-gray-600">Receptor GLP-1 acoplado a proteína G (GLP-1R) distribuido en múltiples órganos</p>
</li>
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<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
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<p class="ml-3 text-gray-600">Activación de AMPK y otras vías intracelulares</p>
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<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
<i class="fas fa-check text-xs"></i>
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<p class="ml-3 text-gray-600">Influencia en la plasticidad sináptica neuronal</p>
</li>
</ul>
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<h3 class="text-lg font-medium text-indigo-600 mb-4">Áreas prometedoras</h3>
<ul class="space-y-4">
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<p class="ml-3 text-gray-600">Potencial en enfermedades neurodegenerativas</p>
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<i class="fas fa-heart text-xs"></i>
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<p class="ml-3 text-gray-600">Efectos cardioprotectores en insuficiencia cardíaca</p>
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<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
<i class="fas fa-weight text-xs"></i>
</span>
<p class="ml-3 text-gray-600">Nuevos análogos con mayor duración de acción</p>
</li>
</ul>
</div>
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</div>
<div class="ml-4">
<h4 class="text-lg font-medium text-gray-900">Impacto en diabetes tipo 2</h4>
<p class="mt-2 text-gray-600">
Los análogos de GLP-1 han revolucionado el tratamiento de la diabetes tipo 2, no solo mejorando el control glucémico sino también promoviendo la pérdida de peso y mostrando efectos protectores cardiovasculares en ensayos clínicos.
</p>
</div>
</div>
</div>
</div>
</div>
</div>
</div>
<!-- Applications Section -->
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<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Usos terapéuticos</h2>
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
Aplicaciones clínicas de GLP-1
</p>
<p class="mt-4 max-w-2xl text-xl text-gray-500 mx-auto">
Terapias basadas en GLP-1 para diversas condiciones médicas.
</p>
</div>
<div class="mt-12">
<div class="grid grid-cols-1 gap-8 sm:grid-cols-2 lg:grid-cols-3">
<!-- App 1 -->
<div class="pt-6">
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<div class="-mt-6">
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
<i class="fas fa-vial text-xl"></i>
</div>
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Diabetes Mellitus Tipo 2</h3>
<p class="mt-5 text-base text-gray-500">
Análogos de GLP-1 como exenatida, liraglutida, dulaglutida, y semaglutida mejoran el control glucémico con bajo riesgo de hipoglucemia.
</p>
</div>
</div>
</div>
<!-- App 2 -->
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<div class="-mt-6">
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<i class="fas fa-weight text-xl"></i>
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<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Obesidad</h3>
<p class="mt-5 text-base text-gray-500">
Liraglutida y semaglutida en dosis más altas están aprobadas para el tratamiento de la obesidad, mostrando reducciones significativas de peso.
</p>
</div>
</div>
</div>
<!-- App 3 -->
<div class="pt-6">
<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
<div class="-mt-6">
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
<i class="fas fa-brain text-xl"></i>
</div>
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Enfermedades Neurodegenerativas</h3>
<p class="mt-5 text-base text-gray-500">
En investigación para enfermedades como Alzheimer y Parkinson, mostrando potencial neuroprotector en modelos animales.
</p>
</div>
</div>
</div>
<!-- App 4 -->
<div class="pt-6">
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<i class="fas fa-heart text-xl"></i>
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<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Enfermedad Cardiovascular</h3>
<p class="mt-5 text-base text-gray-500">
Algunos análogos han demostrado reducir eventos cardiovasculares mayores en pacientes con diabetes y enfermedad cardiovascular establecida.
</p>
</div>
</div>
</div>
<!-- App 5 -->
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<i class="fas fa-pills text-xl"></i>
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<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Síndrome Metabólico</h3>
<p class="mt-5 text-base text-gray-500">
Beneficios sobre múltiples componentes del síndrome metabólico, incluyendo resistencia a la insulina, obesidad abdominal y dislipidemia.
</p>
</div>
</div>
</div>
<!-- App 6 -->
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<i class="fas fa-liver text-xl"></i>
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<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">EHNA (Esteatohepatitis No Alcohólica)</h3>
<p class="mt-5 text-base text-gray-500">
Estudios en curso analizan su potencial para reducir la inflamación y fibrosis hepática en pacientes con EHNA.
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<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2005</td>
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-0.7 a -1.3%</td>
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2-3 kg</td>
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<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-0.8 a -1.5%</td>
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<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-1.0 a -1.6%</td>
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">1-3 kg</td>
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<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">-1.5 a -2.0%</td>
<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">5-10 kg (15% en obesidad)</td>
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