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glp1 plasticita 10slides - Initial Deployment

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Files changed (3) hide show
  1. README.md +7 -5
  2. index.html +538 -19
  3. prompts.txt +1 -0
README.md CHANGED
@@ -1,10 +1,12 @@
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  ---
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- title: Ricercheaa
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- emoji: 💻
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- colorFrom: green
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- colorTo: purple
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  sdk: static
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  pinned: false
 
 
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  ---
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- Check out the configuration reference at https://huggingface.co/docs/hub/spaces-config-reference
 
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  ---
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+ title: ricercheaa
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+ emoji: 🐳
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+ colorFrom: gray
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+ colorTo: green
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  sdk: static
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  pinned: false
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+ tags:
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+ - deepsite
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  ---
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+ Check out the configuration reference at https://huggingface.co/docs/hub/spaces-config-reference
index.html CHANGED
@@ -1,19 +1,538 @@
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- <!doctype html>
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- <html>
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- <head>
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- <meta charset="utf-8" />
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- <meta name="viewport" content="width=device-width" />
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- <title>My static Space</title>
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- <link rel="stylesheet" href="style.css" />
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- </head>
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- <body>
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- <div class="card">
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- <h1>Welcome to your static Space!</h1>
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- <p>You can modify this app directly by editing <i>index.html</i> in the Files and versions tab.</p>
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- <p>
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- Also don't forget to check the
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- <a href="https://huggingface.co/docs/hub/spaces" target="_blank">Spaces documentation</a>.
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- </p>
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- </div>
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- </body>
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- </html>
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ <!DOCTYPE html>
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+ <html lang="en">
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+ <head>
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+ <meta charset="UTF-8">
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+ <meta name="viewport" content="width=device-width, initial-scale=1.0">
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+ <title>GLP-1 Plasticity</title>
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+ <script src="https://cdn.tailwindcss.com"></script>
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+ <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/6.4.0/css/all.min.css">
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+ <style>
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+ .slide {
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+ display: none;
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+ opacity: 0;
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+ transition: opacity 0.5s ease;
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+ }
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+ .slide.active {
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+ display: block;
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+ opacity: 1;
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+ }
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+ .progress-bar {
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+ height: 5px;
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+ background-color: #3b82f6;
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+ transition: width 0.3s ease;
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+ }
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+ @keyframes pulse {
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+ 0% { transform: scale(1); }
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+ 50% { transform: scale(1.05); }
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+ 100% { transform: scale(1); }
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+ }
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+ .pulse {
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+ animation: pulse 2s infinite;
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+ }
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+ </style>
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+ </head>
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+ <body class="font-sans bg-gray-100">
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+ <!-- Navigation Controls -->
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+ <div class="fixed bottom-6 left-0 right-0 flex justify-center z-50">
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+ <button id="prevBtn" class="mx-2 p-3 bg-blue-600 text-white rounded-full shadow-lg hover:bg-blue-700 transition">
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+ <i class="fas fa-arrow-left"></i>
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+ </button>
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+ <button id="nextBtn" class="mx-2 p-3 bg-blue-600 text-white rounded-full shadow-lg hover:bg-blue-700 transition">
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+ <i class="fas fa-arrow-right"></i>
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+ </button>
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+ </div>
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+
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+ <!-- Progress Bar -->
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+ <div class="fixed top-0 left-0 right-0 h-1 bg-gray-200 z-50">
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+ <div id="progressBar" class="progress-bar h-full"></div>
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+ </div>
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+
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+ <!-- Slide Indicators -->
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+ <div class="fixed top-4 right-4 flex z-50">
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+ <div class="flex space-x-2">
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="0"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="1"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="2"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="3"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="4"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="5"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="6"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="7"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="8"></div>
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+ <div class="w-3 h-3 rounded-full bg-gray-300 slide-indicator" data-slide="9"></div>
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+ </div>
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+ </div>
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+
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+ <!-- Slide Container -->
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+ <div class="relative h-screen w-full overflow-hidden">
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+ <!-- Slide 1: Title Slide -->
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+ <div class="slide active h-full w-full flex flex-col justify-center items-center p-8 text-center bg-gradient-to-br from-blue-50 to-indigo-100">
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+ <div class="max-w-4xl">
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+ <h1 class="text-5xl md:text-7xl font-bold text-blue-800 mb-6">GLP-1 Plasticity</h1>
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+ <p class="text-xl md:text-2xl text-gray-700 mb-10">Exploring the Neuroplastic Effects of Glucagon-Like Peptide-1</p>
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+ <div class="flex justify-center">
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+ <div class="p-4 bg-white rounded-lg shadow-md inline-block">
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+ <i class="fas fa-brain text-4xl text-indigo-600 mb-2"></i>
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+ <p class="text-gray-600">Neuroscience Presentation</p>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+
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+ <!-- Slide 2: GLP-1 Overview -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-green-50 to-teal-100">
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+ <div class="max-w-6xl mx-auto grid md:grid-cols-2 gap-10 items-center">
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+ <div>
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+ <h2 class="text-4xl font-bold text-teal-800 mb-4">What is GLP-1?</h2>
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+ <ul class="space-y-4 text-lg text-gray-700">
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+ <li class="flex items-start">
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+ <i class="fas fa-check-circle text-teal-500 mt-1 mr-2"></i>
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+ <span>Glucagon-like peptide-1 (GLP-1) is an incretin hormone</span>
91
+ </li>
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+ <li class="flex items-start">
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+ <i class="fas fa-check-circle text-teal-500 mt-1 mr-2"></i>
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+ <span>Produced in intestinal L-cells and brainstem neurons</span>
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+ </li>
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+ <li class="flex items-start">
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+ <i class="fas fa-check-circle text-teal-500 mt-1 mr-2"></i>
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+ <span>Primarily known for glucose regulation and incretin effects</span>
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+ </li>
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+ <li class="flex items-start">
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+ <i class="fas fa-check-circle text-teal-500 mt-1 mr-2"></i>
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+ <span>Emerging evidence for neuroprotective and neurotrophic effects</span>
103
+ </li>
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+ </ul>
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+ </div>
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+ <div class="bg-white p-6 rounded-xl shadow-lg">
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+ <img src="https://upload.wikimedia.org/wikipedia/commons/thumb/b/b2/GLP-1_physiology2.svg/1200px-GLP-1_physiology2.svg.png" alt="GLP-1 Physiology" class="rounded-lg w-full h-auto">
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+ </div>
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+ </div>
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+ </div>
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+
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+ <!-- Slide 3: GLP-1 and Neuroplasticity -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-purple-50 to-indigo-100">
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+ <div class="max-w-4xl mx-auto">
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+ <h2 class="text-4xl font-bold text-indigo-800 mb-6">GLP-1 and Neuroplasticity</h2>
116
+ <div class="grid md:grid-cols-3 gap-6 mb-10">
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+ <div class="bg-white p-5 rounded-lg shadow-md text-center pulse">
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+ <i class="fas fa-seedling text-4xl text-green-500 mb-3"></i>
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+ <h3 class="font-semibold text-lg mb-2">Synaptic Plasticity</h3>
120
+ <p class="text-gray-600">Enhances LTP and modulates synaptic strength</p>
121
+ </div>
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+ <div class="bg-white p-5 rounded-lg shadow-md text-center pulse">
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+ <i class="fas fa-network-wired text-4xl text-blue-500 mb-3"></i>
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+ <h3 class="font-semibold text-lg mb-2">Neurogenesis</h3>
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+ <p class="text-gray-600">Promotes neuronal proliferation and differentiation</p>
126
+ </div>
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+ <div class="bg-white p-5 rounded-lg shadow-md text-center pulse">
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+ <i class="fas fa-shield-alt text-4xl text-purple-500 mb-3"></i>
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+ <h3 class="font-semibold text-lg mb-2">Neuroprotection</h3>
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+ <p class="text-gray-600">Reduces oxidative stress and inflammation</p>
131
+ </div>
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+ </div>
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+ <div class="bg-indigo-100 p-4 rounded-lg border-l-4 border-indigo-500">
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+ <p class="text-indigo-800"><i class="fas fa-info-circle mr-2"></i> GLP-1 receptors are widely expressed in the brain, including hippocampus and cortex - key areas for learning and memory.</p>
135
+ </div>
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+ </div>
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+ </div>
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+
139
+ <!-- Slide 4: Molecular Mechanisms -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-red-50 to-pink-100">
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+ <div class="max-w-6xl mx-auto">
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+ <h2 class="text-4xl font-bold text-pink-800 mb-8">Molecular Mechanisms</h2>
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+ <div class="grid md:grid-cols-2 gap-10">
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+ <div>
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+ <h3 class="text-2xl font-semibold text-pink-700 mb-4">Signaling Pathways</h3>
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+ <ul class="space-y-4 text-gray-700">
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+ <li class="flex">
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+ <span class="bg-pink-600 text-white rounded-full w-6 h-6 flex items-center justify-center mr-3 flex-shrink-0">1</span>
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+ <span>Activation of GLP-1R (G-protein coupled receptor)</span>
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+ </li>
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+ <li class="flex">
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+ <span class="bg-pink-600 text-white rounded-full w-6 h-6 flex items-center justify-center mr-3 flex-shrink-0">2</span>
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+ <span>cAMP/PKA and PI3K/Akt pathway activation</span>
154
+ </li>
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+ <li class="flex">
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+ <span class="bg-pink-600 text-white rounded-full w-6 h-6 flex items-center justify-center mr-3 flex-shrink-0">3</span>
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+ <span>BDNF upregulation and TrkB signaling</span>
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+ </li>
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+ <li class="flex">
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+ <span class="bg-pink-600 text-white rounded-full w-6 h-6 flex items-center justify-center mr-3 flex-shrink-0">4</span>
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+ <span>CREB phosphorylation and gene transcription</span>
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+ </li>
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+ </ul>
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+ </div>
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+ <div class="bg-white p-4 rounded-lg shadow-lg">
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+ <div class="relative h-full w-full">
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+ <div class="absolute inset-0 flex items-center justify-center">
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+ <i class="fas fa-atom text-6xl text-pink-300 opacity-50"></i>
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+ </div>
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+ <div class="relative flex flex-col items-center">
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+ <div class="w-16 h-16 rounded-full bg-pink-500 flex items-center justify-center text-white mb-3">
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+ <i class="fas fa-dna"></i>
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+ </div>
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+ <div class="w-32 h-32 rounded-full border-4 border-pink-300 flex items-center justify-center text-pink-500 mb-3">
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+ <i class="fas fa-project-diagram text-3xl"></i>
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+ </div>
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+ <div class="w-48 h-48 rounded-full border-8 border-pink-200 flex items-center justify-center">
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+ <div class="text-center">
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+ <i class="fas fa-brain text-4xl text-pink-600 mb-2"></i>
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+ <p class="text-xs font-semibold text-pink-700">Neuronal Plasticity</p>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+
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+ <!-- Slide 5: Therapeutic Implications -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-yellow-50 to-amber-100">
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+ <div class="max-w-5xl mx-auto">
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+ <h2 class="text-4xl font-bold text-amber-800 mb-8">Therapeutic Implications</h2>
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+ <div class="grid md:grid-cols-3 gap-6">
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+ <div class="bg-white rounded-xl shadow-md overflow-hidden">
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+ <div class="bg-amber-500 p-4 text-white font-semibold">
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+ <i class="fas fa-brain mr-2"></i> Alzheimer's Disease
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+ </div>
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+ <div class="p-4">
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+ <p class="text-gray-700">GLP-1 analogs show potential in reducing amyloid-β plaques and improving cognitive function.</p>
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+ </div>
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+ </div>
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+ <div class="bg-white rounded-xl shadow-md overflow-hidden">
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+ <div class="bg-amber-600 p-4 text-white font-semibold">
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+ <i class="fas fa-parking mr-2"></i> Parkinson's Disease
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+ </div>
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+ <div class="p-4">
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+ <p class="text-gray-700">Neuroprotective effects may help preserve dopaminergic neurons and motor function.</p>
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+ </div>
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+ </div>
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+ <div class="bg-white rounded-xl shadow-md overflow-hidden">
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+ <div class="bg-amber-700 p-4 text-white font-semibold">
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+ <i class="fas fa-bolt mr-2"></i> Stroke Recovery
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+ </div>
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+ <div class="p-4">
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+ <p class="text-gray-700">Enhances neuroplasticity during rehabilitation and reduces infarct volume.</p>
217
+ </div>
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+ </div>
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+ </div>
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+ <div class="mt-8 bg-amber-100 p-4 rounded-lg border-l-4 border-amber-400">
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+ <p class="text-amber-900"><i class="fas fa-flask mr-2"></i> Several clinical trials are currently investigating GLP-1 analogs (e.g., exenatide, liraglutide) for neurodegenerative disorders.</p>
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+ </div>
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+ </div>
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+ </div>
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+
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+ <!-- Slide 6: Animal Studies -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-blue-50 to-cyan-100">
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+ <div class="max-w-6xl mx-auto">
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+ <h2 class="text-4xl font-bold text-cyan-800 mb-8">Evidence from Animal Studies</h2>
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+ <div class="grid md:grid-cols-2 gap-8">
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+ <div>
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+ <div class="bg-white p-5 rounded-lg shadow-lg mb-6">
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+ <div class="flex items-start">
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+ <div class="bg-cyan-100 p-3 rounded-full mr-4">
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+ <i class="fas fa-microscope text-cyan-600"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg mb-2">Hippocampal Plasticity</h3>
239
+ <p class="text-gray-700">GLP-1 analogs enhance LTP in hippocampal slices and improve spatial memory in rodents.</p>
240
+ </div>
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+ </div>
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+ </div>
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+ <div class="bg-white p-5 rounded-lg shadow-lg">
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+ <div class="flex items-start">
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+ <div class="bg-cyan-100 p-3 rounded-full mr-4">
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+ <i class="fas fa-dna text-cyan-600"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg mb-2">Molecular Changes</h3>
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+ <p class="text-gray-700">Upregulation of synaptic proteins (PSD-95, synaptophysin) and BDNF in treated animals.</p>
251
+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ <div>
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+ <div class="bg-white p-5 rounded-lg shadow-lg mb-6">
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+ <div class="flex items-start">
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+ <div class="bg-cyan-100 p-3 rounded-full mr-4">
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+ <i class="fas fa-brain text-cyan-600"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg mb-2">Neuroprotection</h3>
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+ <p class="text-gray-700">Reduced neuronal loss in models of stroke, Alzheimer's, and Parkinson's disease.</p>
264
+ </div>
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+ </div>
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+ </div>
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+ <div class="bg-white p-5 rounded-lg shadow-lg">
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+ <div class="flex items-start">
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+ <div class="bg-cyan-100 p-3 rounded-full mr-4">
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+ <i class="fas fa-seedling text-cyan-600"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg mb-2">Neurogenesis</h3>
274
+ <p class="text-gray-700">Increased proliferation of neural progenitor cells in the subventricular zone and dentate gyrus.</p>
275
+ </div>
276
+ </div>
277
+ </div>
278
+ </div>
279
+ </div>
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+ </div>
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+ </div>
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+
283
+ <!-- Slide 7: Clinical Evidence -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-green-50 to-emerald-100">
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+ <div class="max-w-5xl mx-auto">
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+ <h2 class="text-4xl font-bold text-emerald-800 mb-8">Clinical Evidence</h2>
287
+ <div class="overflow-hidden rounded-xl shadow-lg bg-white">
288
+ <table class="min-w-full">
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+ <thead class="bg-emerald-600 text-white">
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+ <tr>
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+ <th class="py-3 px-4 text-left">Study</th>
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+ <th class="py-3 px-4 text-left">Population</th>
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+ <th class="py-3 px-4 text-left">Findings</th>
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+ </tr>
295
+ </thead>
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+ <tbody class="divide-y divide-gray-200">
297
+ <tr>
298
+ <td class="py-3 px-4">Exenatide-PD</td>
299
+ <td class="py-3 px-4">Parkinson's patients</td>
300
+ <td class="py-3 px-4">Improved motor scores (UPDRS) after 12 months</td>
301
+ </tr>
302
+ <tr class="bg-emerald-50">
303
+ <td class="py-3 px-4">ELAD Trial</td>
304
+ <td class="py-3 px-4">Early Alzheimer's</td>
305
+ <td class="py-3 px-4">Slowed cognitive decline vs placebo</td>
306
+ </tr>
307
+ <tr>
308
+ <td class="py-3 px-4">Liraglutide-AD</td>
309
+ <td class="py-3 px-4">Alzheimer's patients</td>
310
+ <td class="py-3 px-4">Reduced brain atrophy on MRI</td>
311
+ </tr>
312
+ <tr class="bg-emerald-50">
313
+ <td class="py-3 px-4">Meta-analysis</td>
314
+ <td class="py-3 px-4">Type 2 Diabetes</td>
315
+ <td class="py-3 px-4">Lower dementia incidence in GLP-1 users</td>
316
+ </tr>
317
+ </tbody>
318
+ </table>
319
+ </div>
320
+ <div class="mt-6 p-4 bg-emerald-100 rounded-lg">
321
+ <p class="text-emerald-800"><i class="fas fa-stethoscope mr-2"></i> While promising, larger phase 3 trials are needed to confirm efficacy in neurodegenerative diseases.</p>
322
+ </div>
323
+ </div>
324
+ </div>
325
+
326
+ <!-- Slide 8: Current Limitations -->
327
+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-gray-50 to-blue-gray-100">
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+ <div class="max-w-4xl mx-auto">
329
+ <h2 class="text-4xl font-bold text-gray-800 mb-8">Current Limitations</h2>
330
+ <div class="space-y-6">
331
+ <div class="flex items-start">
332
+ <div class="bg-gray-200 p-3 rounded-full mr-4">
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+ <i class="fas fa-question text-gray-700"></i>
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+ </div>
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+ <div>
336
+ <h3 class="font-semibold text-lg text-gray-800">Blood-Brain Barrier Penetration</h3>
337
+ <p class="text-gray-600">Most GLP-1 analogs have limited ability to cross the BBB in therapeutic concentrations</p>
338
+ </div>
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+ </div>
340
+ <div class="flex items-start">
341
+ <div class="bg-gray-200 p-3 rounded-full mr-4">
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+ <i class="fas fa-clock text-gray-700"></i>
343
+ </div>
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+ <div>
345
+ <h3 class="font-semibold text-lg text-gray-800">Long-term Effects Unknown</h3>
346
+ <p class="text-gray-600">Neuroplasticity changes may require sustained treatment over years</p>
347
+ </div>
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+ </div>
349
+ <div class="flex items-start">
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+ <div class="bg-gray-200 p-3 rounded-full mr-4">
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+ <i class="fas fa-puzzle-piece text-gray-700"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg text-gray-800">Mechanistic Complexity</h3>
355
+ <p class="text-gray-600">Precise pathways mediating neuroplastic effects not fully elucidated</p>
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+ </div>
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+ </div>
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+ <div class="flex items-start">
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+ <div class="bg-gray-200 p-3 rounded-full mr-4">
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+ <i class="fas fa-tablets text-gray-700"></i>
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+ </div>
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+ <div>
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+ <h3 class="font-semibold text-lg text-gray-800">Side Effects</h3>
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+ <p class="text-gray-600">Gastrointestinal effects may limit tolerability in some patients</p>
365
+ </div>
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+ </div>
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+ </div>
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+ </div>
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+ </div>
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+
371
+ <!-- Slide 9: Future Directions -->
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+ <div class="slide h-full w-full flex items-center p-8 bg-gradient-to-br from-indigo-50 to-violet-100">
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+ <div class="max-w-6xl mx-auto">
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+ <h2 class="text-4xl font-bold text-violet-800 mb-8">Future Directions</h2>
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+ <div class="grid md:grid-cols-2 gap-8">
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+ <div class="bg-white p-6 rounded-xl shadow-md">
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+ <div class="flex items-center mb-4">
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+ <div class="bg-violet-600 p-3 rounded-full text-white mr-4">
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+ <i class="fas fa-rocket"></i>
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+ </div>
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+ <h3 class="text-xl font-semibold text-violet-800">Next-Gen Analogs</h3>
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+ </div>
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+ <p class="text-gray-700">Developing GLP-1 analogs with enhanced BBB penetration and CNS selectivity could improve efficacy for neurodegenerative disorders.</p>
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+ </div>
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+ <div class="bg-white p-6 rounded-xl shadow-md">
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+ <div class="flex items-center mb-4">
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+ <div class="bg-violet-500 p-3 rounded-full text-white mr-4">
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+ <i class="fas fa-cogs"></i>
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+ </div>
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+ <h3 class="text-xl font-semibold text-violet-800">Combination Therapies</h3>
391
+ </div>
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+ <p class="text-gray-700">Exploring synergistic effects with other neuroprotective agents (e.g., BDNF mimetics, anti-inflammatories) may enhance plasticity.</p>
393
+ </div>
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+ <div class="bg-white p-6 rounded-xl shadow-md">
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+ <div class="flex items-center mb-4">
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+ <div class="bg-violet-400 p-3 rounded-full text-white mr-4">
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+ <i class="fas fa-chart-line"></i>
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+ </div>
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+ <h3 class="text-xl font-semibold text-violet-800">Biomarkers</h3>
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+ </div>
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+ <p class="text-gray-700">Identifying reliable biomarkers of GLP-1-mediated neuroplasticity could help personalize treatment approaches.</p>
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+ </div>
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+ <div class="bg-white p-6 rounded-xl shadow-md">
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+ <div class="flex items-center mb-4">
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+ <div class="bg-violet-300 p-3 rounded-full text-white mr-4">
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+ <i class="fas fa-recycle"></i>
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+ </div>
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+ <h3 class="text-xl font-semibold text-violet-800">Rehabilitation</h3>
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+ </div>
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+ <p class="text-gray-700">Investigating how GLP-1 analogs can augment the effects of cognitive rehabilitation and physical therapy.</p>
411
+ </div>
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+ </div>
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+ </div>
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+ </div>
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+
416
+ <!-- Slide 10: Conclusion -->
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+ <div class="slide h-full w-full flex flex-col items-center justify-center p-8 bg-gradient-to-br from-blue-900 to-indigo-900 text-white text-center">
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+ <div class="max-w-3xl">
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+ <h2 class="text-5xl font-bold mb-8">Key Takeaways</h2>
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+ <div class="space-y-6 mb-10 text-left">
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+ <div class="flex items-start">
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+ <div class="bg-blue-600 p-2 rounded-full mr-4">
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+ <i class="fas fa-check"></i>
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+ </div>
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+ <p class="text-xl">GLP-1 exhibits neuroplastic effects through multiple molecular mechanisms</p>
426
+ </div>
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+ <div class="flex items-start">
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+ <div class="bg-blue-600 p-2 rounded-full mr-4">
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+ <i class="fas fa-check"></i>
430
+ </div>
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+ <p class="text-xl">Preclinical evidence strongly supports neuroprotective and plasticity-enhancing properties</p>
432
+ </div>
433
+ <div class="flex items-start">
434
+ <div class="bg-blue-600 p-2 rounded-full mr-4">
435
+ <i class="fas fa-check"></i>
436
+ </div>
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+ <p class="text-xl">Early clinical trials show promise for neurodegenerative disorders</p>
438
+ </div>
439
+ <div class="flex items-start">
440
+ <div class="bg-blue-600 p-2 rounded-full mr-4">
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+ <i class="fas fa-check"></i>
442
+ </div>
443
+ <p class="text-xl">GLP-1-based therapies may represent a novel approach to enhance brain plasticity</p>
444
+ </div>
445
+ </div>
446
+ <div class="mt-8 pt-6 border-t border-blue-300">
447
+ <p class="text-blue-200">Thank you for your attention!</p>
448
+ <p class="text-blue-300 mt-2">Questions?</p>
449
+ </div>
450
+ </div>
451
+ </div>
452
+ </div>
453
+
454
+ <script>
455
+ document.addEventListener('DOMContentLoaded', function() {
456
+ const slides = document.querySelectorAll('.slide');
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+ const prevBtn = document.getElementById('prevBtn');
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+ const nextBtn = document.getElementById('nextBtn');
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+ const progressBar = document.getElementById('progressBar');
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+ const indicators = document.querySelectorAll('.slide-indicator');
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+ let currentSlide = 0;
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+ const totalSlides = slides.length;
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+
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+ // Initialize first slide
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+ showSlide(currentSlide);
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+
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+ // Next button click handler
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+ nextBtn.addEventListener('click', function() {
469
+ if (currentSlide < totalSlides - 1) {
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+ currentSlide++;
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+ showSlide(currentSlide);
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+ }
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+ });
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+
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+ // Previous button click handler
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+ prevBtn.addEventListener('click', function() {
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+ if (currentSlide > 0) {
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+ currentSlide--;
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+ showSlide(currentSlide);
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+ }
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+ // Indicator click handler
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+ indicators.forEach((indicator, index) => {
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+ indicator.addEventListener('click', function() {
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+ currentSlide = index;
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+ showSlide(currentSlide);
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+ });
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+ });
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+
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+ // Keyboard navigation
492
+ document.addEventListener('keydown', function(e) {
493
+ if (e.key === 'ArrowRight') {
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+ if (currentSlide < totalSlides - 1) {
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+ currentSlide++;
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+ showSlide(currentSlide);
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+ }
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+ } else if (e.key === 'ArrowLeft') {
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+ if (currentSlide > 0) {
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+ currentSlide--;
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+ showSlide(currentSlide);
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+ }
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+ }
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+
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+ // Show specific slide
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+ function showSlide(index) {
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+ // Hide all slides
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+ slides.forEach(slide => {
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+ slide.classList.remove('active');
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+ });
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+
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+ // Show current slide
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+ slides[index].classList.add('active');
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+
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+ // Update progress bar
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+ const progress = ((index + 1) / totalSlides) * 100;
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+ progressBar.style.width = `${progress}%`;
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+
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+ // Update indicators
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+ indicators.forEach((indicator, i) => {
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+ if (i === index) {
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+ indicator.classList.remove('bg-gray-300');
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+ indicator.classList.add('bg-blue-500');
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+ } else {
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+ indicator.classList.remove('bg-blue-500');
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+ indicator.classList.add('bg-gray-300');
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+
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+ // Disable/enable navigation buttons
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+ prevBtn.disabled = index === 0;
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+ nextBtn.disabled = index === totalSlides - 1;
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+ }
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+ });
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+ </script>
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+ <p style="border-radius: 8px; text-align: center; font-size: 12px; color: #fff; margin-top: 16px;position: fixed; left: 8px; bottom: 8px; z-index: 10; background: rgba(0, 0, 0, 0.8); padding: 4px 8px;">Made with <img src="https://enzostvs-deepsite.hf.space/logo.svg" alt="DeepSite Logo" style="width: 16px; height: 16px; vertical-align: middle;display:inline-block;margin-right:3px;filter:brightness(0) invert(1);"><a href="https://enzostvs-deepsite.hf.space" style="color: #fff;text-decoration: underline;" target="_blank" >DeepSite</a> - 🧬 <a href="https://enzostvs-deepsite.hf.space?remix=venezianof/ricercheaa" style="color: #fff;text-decoration: underline;" target="_blank" >Remix</a></p></body>
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+ </html>
prompts.txt ADDED
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+ glp1 plasticita 10slides