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<title>GLP-1
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<!-- Slide 1: Title Slide -->
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<div class="max-w-4xl">
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<h1 class="text-5xl md:text-7xl font-bold text-blue-800 mb-6">GLP-1 Plasticity</h1>
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<p class="text-xl md:text-2xl text-gray-700 mb-10">Exploring the Neuroplastic Effects of Glucagon-Like Peptide-1</p>
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<p class="text-gray-600">Neuroscience Presentation</p>
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<h2 class="text-4xl font-bold text-teal-800 mb-4">What is GLP-1?</h2>
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<span>Glucagon-like peptide-1 (GLP-1) is an incretin hormone</span>
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<span>Produced in intestinal L-cells and brainstem neurons</span>
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<span>Primarily known for glucose regulation and incretin effects</span>
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<span>Emerging evidence for neuroprotective and neurotrophic effects</span>
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<h3 class="font-semibold text-lg mb-2">Synaptic Plasticity</h3>
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<p class="text-gray-600">Enhances LTP and modulates synaptic strength</p>
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<h3 class="font-semibold text-lg mb-2">Neurogenesis</h3>
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<p class="text-gray-600">Promotes neuronal proliferation and differentiation</p>
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<h3 class="font-semibold text-lg mb-2">Neuroprotection</h3>
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<p class="text-gray-600">Reduces oxidative stress and inflammation</p>
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<p class="text-indigo-800"><i class="fas fa-info-circle mr-2"></i> GLP-1 receptors are widely expressed in the brain, including hippocampus and cortex - key areas for learning and memory.</p>
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<span>CREB phosphorylation and gene transcription</span>
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<p class="text-xs font-semibold text-pink-700">Neuronal Plasticity</p>
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<p class="text-gray-700">Neuroprotective effects may help preserve dopaminergic neurons and motor function.</p>
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<p class="text-amber-900"><i class="fas fa-flask mr-2"></i> Several clinical trials are currently investigating GLP-1 analogs (e.g., exenatide, liraglutide) for neurodegenerative disorders.</p>
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<p class="text-gray-700">GLP-1 analogs enhance LTP in hippocampal slices and improve spatial memory in rodents.</p>
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<p class="text-gray-700">Upregulation of synaptic proteins (PSD-95, synaptophysin) and BDNF in treated animals.</p>
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<p class="text-gray-700">Reduced neuronal loss in models of stroke, Alzheimer's, and Parkinson's disease.</p>
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<p class="text-gray-700">Increased proliferation of neural progenitor cells in the subventricular zone and dentate gyrus.</p>
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<td class="py-3 px-4">Exenatide-PD</td>
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<td class="py-3 px-4">Parkinson's patients</td>
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<td class="py-3 px-4">Improved motor scores (UPDRS) after 12 months</td>
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<td class="py-3 px-4">Early Alzheimer's</td>
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<td class="py-3 px-4">Slowed cognitive decline vs placebo</td>
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<td class="py-3 px-4">Liraglutide-AD</td>
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<td class="py-3 px-4">Alzheimer's patients</td>
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<td class="py-3 px-4">Reduced brain atrophy on MRI</td>
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<td class="py-3 px-4">Meta-analysis</td>
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<td class="py-3 px-4">Type 2 Diabetes</td>
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<td class="py-3 px-4">Lower dementia incidence in GLP-1 users</td>
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<p class="text-emerald-800"><i class="fas fa-stethoscope mr-2"></i> While promising, larger phase 3 trials are needed to confirm efficacy in neurodegenerative diseases.</p>
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<h2 class="text-4xl font-bold text-gray-800 mb-8">Current Limitations</h2>
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<h3 class="text-xl font-semibold text-violet-800">Next-Gen Analogs</h3>
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</div>
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<p class="text-gray-700">Developing GLP-1 analogs with enhanced BBB penetration and CNS selectivity could improve efficacy for neurodegenerative disorders.</p>
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<h3 class="text-xl font-semibold text-violet-800">Combination Therapies</h3>
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<p class="text-gray-700">Exploring synergistic effects with other neuroprotective agents (e.g., BDNF mimetics, anti-inflammatories) may enhance plasticity.</p>
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<h3 class="text-xl font-semibold text-violet-800">Biomarkers</h3>
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</div>
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<p class="text-gray-700">Identifying reliable biomarkers of GLP-1-mediated neuroplasticity could help personalize treatment approaches.</p>
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</div>
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<h3 class="text-xl font-semibold text-violet-800">Rehabilitation</h3>
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</div>
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<p class="text-gray-700">Investigating how GLP-1 analogs can augment the effects of cognitive rehabilitation and physical therapy.</p>
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<i class="fas fa-check"></i>
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</div>
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<p class="text-xl">Preclinical evidence strongly supports neuroprotective and plasticity-enhancing properties</p>
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</div>
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<p class="text-xl">Early clinical trials show promise for neurodegenerative disorders</p>
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| 442 |
</div>
|
| 443 |
-
<p class="text-xl">GLP-1-based therapies may represent a novel approach to enhance brain plasticity</p>
|
| 444 |
</div>
|
| 445 |
</div>
|
| 446 |
-
<div class="mt-8 pt-6 border-t border-blue-300">
|
| 447 |
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<p class="text-blue-200">Thank you for your attention!</p>
|
| 448 |
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<p class="text-blue-300 mt-2">Questions?</p>
|
| 449 |
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</div>
|
| 450 |
</div>
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| 451 |
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| 454 |
<script>
|
| 455 |
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| 456 |
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const
|
| 458 |
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| 459 |
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| 475 |
-
// Previous button click handler
|
| 476 |
-
prevBtn.addEventListener('click', function() {
|
| 477 |
-
if (currentSlide > 0) {
|
| 478 |
-
currentSlide--;
|
| 479 |
-
showSlide(currentSlide);
|
| 480 |
-
}
|
| 481 |
-
});
|
| 482 |
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|
| 483 |
-
// Indicator click handler
|
| 484 |
-
indicators.forEach((indicator, index) => {
|
| 485 |
-
indicator.addEventListener('click', function() {
|
| 486 |
-
currentSlide = index;
|
| 487 |
-
showSlide(currentSlide);
|
| 488 |
-
});
|
| 489 |
});
|
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| 502 |
}
|
| 503 |
}
|
| 504 |
});
|
| 505 |
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|
| 506 |
-
// Show specific slide
|
| 507 |
-
function showSlide(index) {
|
| 508 |
-
// Hide all slides
|
| 509 |
-
slides.forEach(slide => {
|
| 510 |
-
slide.classList.remove('active');
|
| 511 |
-
});
|
| 512 |
-
|
| 513 |
-
// Show current slide
|
| 514 |
-
slides[index].classList.add('active');
|
| 515 |
-
|
| 516 |
-
// Update progress bar
|
| 517 |
-
const progress = ((index + 1) / totalSlides) * 100;
|
| 518 |
-
progressBar.style.width = `${progress}%`;
|
| 519 |
-
|
| 520 |
-
// Update indicators
|
| 521 |
-
indicators.forEach((indicator, i) => {
|
| 522 |
-
if (i === index) {
|
| 523 |
-
indicator.classList.remove('bg-gray-300');
|
| 524 |
-
indicator.classList.add('bg-blue-500');
|
| 525 |
-
} else {
|
| 526 |
-
indicator.classList.remove('bg-blue-500');
|
| 527 |
-
indicator.classList.add('bg-gray-300');
|
| 528 |
-
}
|
| 529 |
-
});
|
| 530 |
-
|
| 531 |
-
// Disable/enable navigation buttons
|
| 532 |
-
prevBtn.disabled = index === 0;
|
| 533 |
-
nextBtn.disabled = index === totalSlides - 1;
|
| 534 |
-
}
|
| 535 |
});
|
| 536 |
</script>
|
| 537 |
<p style="border-radius: 8px; text-align: center; font-size: 12px; color: #fff; margin-top: 16px;position: fixed; left: 8px; bottom: 8px; z-index: 10; background: rgba(0, 0, 0, 0.8); padding: 4px 8px;">Made with <img src="https://enzostvs-deepsite.hf.space/logo.svg" alt="DeepSite Logo" style="width: 16px; height: 16px; vertical-align: middle;display:inline-block;margin-right:3px;filter:brightness(0) invert(1);"><a href="https://enzostvs-deepsite.hf.space" style="color: #fff;text-decoration: underline;" target="_blank" >DeepSite</a> - 馃К <a href="https://enzostvs-deepsite.hf.space?remix=venezianof/ricercheaa" style="color: #fff;text-decoration: underline;" target="_blank" >Remix</a></p></body>
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| 1 |
<!DOCTYPE html>
|
| 2 |
+
<html lang="es">
|
| 3 |
<head>
|
| 4 |
<meta charset="UTF-8">
|
| 5 |
<meta name="viewport" content="width=device-width, initial-scale=1.0">
|
| 6 |
+
<title>GLP-1 Prote铆na: La Hormona Clave en el Metabolismo</title>
|
| 7 |
<script src="https://cdn.tailwindcss.com"></script>
|
| 8 |
+
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/6.0.0/css/all.min.css">
|
| 9 |
<style>
|
| 10 |
+
@keyframes float {
|
| 11 |
+
0% { transform: translateY(0px); }
|
| 12 |
+
50% { transform: translateY(-10px); }
|
| 13 |
+
100% { transform: translateY(0px); }
|
| 14 |
}
|
| 15 |
+
.floating {
|
| 16 |
+
animation: float 6s ease-in-out infinite;
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|
| 17 |
}
|
| 18 |
+
.gradient-bg {
|
| 19 |
+
background: linear-gradient(135deg, #a5b4fc 0%, #818cf8 50%, #6366f1 100%);
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| 20 |
}
|
| 21 |
+
.card-hover {
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| 22 |
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transition: all 0.3s ease;
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| 23 |
}
|
| 24 |
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.card-hover:hover {
|
| 25 |
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transform: translateY(-5px);
|
| 26 |
+
box-shadow: 0 20px 25px -5px rgba(0, 0, 0, 0.1), 0 10px 10px -5px rgba(0, 0, 0, 0.04);
|
| 27 |
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}
|
| 28 |
+
.smooth-scroll {
|
| 29 |
+
scroll-behavior: smooth;
|
| 30 |
+
}
|
| 31 |
+
.molecule {
|
| 32 |
+
filter: drop-shadow(0 0 5px rgba(99, 102, 241, 0.5));
|
| 33 |
}
|
| 34 |
</style>
|
| 35 |
</head>
|
| 36 |
+
<body class="smooth-scroll bg-gray-50 font-sans antialiased">
|
| 37 |
+
<!-- Navigation -->
|
| 38 |
+
<nav class="bg-white shadow-lg sticky top-0 z-50">
|
| 39 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 40 |
+
<div class="flex justify-between h-16">
|
| 41 |
+
<div class="flex items-center">
|
| 42 |
+
<div class="flex-shrink-0 flex items-center">
|
| 43 |
+
<i class="fas fa-dna text-indigo-500 text-2xl mr-2"></i>
|
| 44 |
+
<span class="text-xl font-bold text-indigo-600">GLP-1</span>
|
| 45 |
+
</div>
|
| 46 |
+
<div class="hidden sm:ml-6 sm:flex sm:space-x-8">
|
| 47 |
+
<a href="#about" class="border-indigo-500 text-gray-900 inline-flex items-center px-1 pt-1 border-b-2 text-sm font-medium">Inicio</a>
|
| 48 |
+
<a href="#functions" class="border-transparent text-gray-500 hover:border-gray-300 hover:text-gray-700 inline-flex items-center px-1 pt-1 border-b-2 text-sm font-medium">Funciones</a>
|
| 49 |
+
<a href="#research" class="border-transparent text-gray-500 hover:border-gray-300 hover:text-gray-700 inline-flex items-center px-1 pt-1 border-b-2 text-sm font-medium">Investigaci贸n</a>
|
| 50 |
+
<a href="#applications" class="border-transparent text-gray-500 hover:border-gray-300 hover:text-gray-700 inline-flex items-center px-1 pt-1 border-b-2 text-sm font-medium">Aplicaciones</a>
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| 51 |
</div>
|
| 52 |
</div>
|
| 53 |
+
<div class="hidden sm:ml-6 sm:flex sm:items-center">
|
| 54 |
+
<button class="bg-indigo-600 hover:bg-indigo-700 text-white px-4 py-2 rounded-md text-sm font-medium transition duration-300">
|
| 55 |
+
M谩s informaci贸n
|
| 56 |
+
</button>
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| 57 |
</div>
|
| 58 |
+
<div class="-mr-2 flex items-center sm:hidden">
|
| 59 |
+
<button type="button" id="mobile-menu-button" class="inline-flex items-center justify-center p-2 rounded-md text-gray-400 hover:text-gray-500 hover:bg-gray-100 focus:outline-none focus:ring-2 focus:ring-inset focus:ring-indigo-500">
|
| 60 |
+
<i class="fas fa-bars"></i>
|
| 61 |
+
</button>
|
| 62 |
</div>
|
| 63 |
</div>
|
| 64 |
</div>
|
| 65 |
+
<!-- Mobile menu -->
|
| 66 |
+
<div class="hidden sm:hidden" id="mobile-menu">
|
| 67 |
+
<div class="pt-2 pb-3 space-y-1">
|
| 68 |
+
<a href="#about" class="bg-indigo-50 border-indigo-500 text-indigo-700 block pl-3 pr-4 py-2 border-l-4 text-base font-medium">Inicio</a>
|
| 69 |
+
<a href="#functions" class="border-transparent text-gray-600 hover:bg-gray-50 hover:border-gray-300 hover:text-gray-800 block pl-3 pr-4 py-2 border-l-4 text-base font-medium">Funciones</a>
|
| 70 |
+
<a href="#research" class="border-transparent text-gray-600 hover:bg-gray-50 hover:border-gray-300 hover:text-gray-800 block pl-3 pr-4 py-2 border-l-4 text-base font-medium">Investigaci贸n</a>
|
| 71 |
+
<a href="#applications" class="border-transparent text-gray-600 hover:bg-gray-50 hover:border-gray-300 hover:text-gray-800 block pl-3 pr-4 py-2 border-l-4 text-base font-medium">Aplicaciones</a>
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|
| 72 |
</div>
|
| 73 |
</div>
|
| 74 |
+
</nav>
|
| 75 |
|
| 76 |
+
<!-- Hero Section -->
|
| 77 |
+
<div id="about" class="gradient-bg text-white py-20 relative overflow-hidden">
|
| 78 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 79 |
+
<div class="relative z-10">
|
| 80 |
+
<div class="text-center">
|
| 81 |
+
<h1 class="text-4xl md:text-6xl font-extrabold tracking-tight mb-6">
|
| 82 |
+
<span class="block">GLP-1</span>
|
| 83 |
+
<span class="block text-2xl md:text-3xl font-medium mt-2">P茅ptido Similar al Glucag贸n 1</span>
|
| 84 |
+
</h1>
|
| 85 |
+
<p class="mt-6 max-w-lg mx-auto text-lg md:text-xl">
|
| 86 |
+
La hormona incretina clave en el metabolismo de la glucosa y el control del apetito.
|
| 87 |
+
</p>
|
| 88 |
+
<div class="mt-10 flex justify-center space-x-4">
|
| 89 |
+
<a href="#functions" class="inline-flex items-center px-6 py-3 border border-transparent text-base font-medium rounded-md text-indigo-600 bg-white hover:bg-gray-100 transition duration-300">
|
| 90 |
+
Explorar funciones <i class="fas fa-arrow-down ml-2"></i>
|
| 91 |
+
</a>
|
| 92 |
+
<a href="#research" class="inline-flex items-center px-6 py-3 border border-transparent text-base font-medium rounded-md text-white bg-indigo-700 hover:bg-indigo-800 transition duration-300">
|
| 93 |
+
Investigaci贸n <i class="fas fa-flask ml-2"></i>
|
| 94 |
+
</a>
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|
| 95 |
</div>
|
| 96 |
</div>
|
| 97 |
</div>
|
| 98 |
</div>
|
| 99 |
+
<div class="absolute top-1/4 left-1/4 w-32 h-32 rounded-full bg-white opacity-10"></div>
|
| 100 |
+
<div class="absolute bottom-20 right-20 w-24 h-24 rounded-full bg-white opacity-10"></div>
|
| 101 |
+
<div class="absolute top-1/3 right-1/3 w-16 h-16 rounded-full bg-white opacity-10"></div>
|
| 102 |
+
|
| 103 |
+
<!-- Floating molecule animation -->
|
| 104 |
+
<div class="absolute top-1/3 right-20 molecule floating hidden md:block">
|
| 105 |
+
<!-- Simple molecule structure using font awesome -->
|
| 106 |
+
<div class="text-white opacity-70 text-6xl">
|
| 107 |
+
<i class="fas fa-atom"></i>
|
| 108 |
+
</div>
|
| 109 |
+
</div>
|
| 110 |
+
</div>
|
| 111 |
|
| 112 |
+
<!-- Quick Facts -->
|
| 113 |
+
<div class="bg-white py-12">
|
| 114 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 115 |
+
<div class="lg:text-center">
|
| 116 |
+
<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Datos clave</h2>
|
| 117 |
+
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
|
| 118 |
+
驴Qu茅 es GLP-1?
|
| 119 |
+
</p>
|
| 120 |
+
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
|
| 121 |
+
El p茅ptido similar al glucag贸n 1 (GLP-1) es una incretina producida en el intestino que juega un papel crucial en el metabolismo.
|
| 122 |
+
</p>
|
| 123 |
+
</div>
|
| 124 |
+
|
| 125 |
+
<div class="mt-10">
|
| 126 |
+
<div class="grid grid-cols-1 gap-10 sm:grid-cols-2 lg:grid-cols-4">
|
| 127 |
+
<div class="bg-indigo-50 rounded-lg p-6 card-hover">
|
| 128 |
+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mb-4">
|
| 129 |
+
<i class="fas fa-clock"></i>
|
| 130 |
</div>
|
| 131 |
+
<h3 class="text-lg font-medium text-gray-900 mb-2">Hormona intestinal</h3>
|
| 132 |
+
<p class="text-gray-500">
|
| 133 |
+
Secretada por las c茅lulas L del intestino en respuesta a la ingesti贸n de alimentos.
|
| 134 |
+
</p>
|
| 135 |
</div>
|
| 136 |
+
|
| 137 |
+
<div class="bg-indigo-50 rounded-lg p-6 card-hover">
|
| 138 |
+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mb-4">
|
| 139 |
+
<i class="fas fa-seedling"></i>
|
|
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|
|
|
|
| 140 |
</div>
|
| 141 |
+
<h3 class="text-lg font-medium text-gray-900 mb-2">Vida media corta</h3>
|
| 142 |
+
<p class="text-gray-500">
|
| 143 |
+
Degradada r谩pidamente por la enzima DPP-4 con una vida media de solo 1-2 minutos.
|
| 144 |
+
</p>
|
| 145 |
</div>
|
| 146 |
+
|
| 147 |
+
<div class="bg-indigo-50 rounded-lg p-6 card-hover">
|
| 148 |
+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mb-4">
|
| 149 |
+
<i class="fas fa-brain"></i>
|
| 150 |
</div>
|
| 151 |
+
<h3 class="text-lg font-medium text-gray-900 mb-2">Acciones m煤ltiples</h3>
|
| 152 |
+
<p class="text-gray-500">
|
| 153 |
+
Act煤a sobre p谩ncreas, cerebro, est贸mago, h铆gado y sistema cardiovascular.
|
| 154 |
+
</p>
|
| 155 |
+
</div>
|
| 156 |
+
|
| 157 |
+
<div class="bg-indigo-50 rounded-lg p-6 card-hover">
|
| 158 |
+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mb-4">
|
| 159 |
+
<i class="fas fa-pills"></i>
|
| 160 |
</div>
|
| 161 |
+
<h3 class="text-lg font-medium text-gray-900 mb-2">Blanco terap茅utico</h3>
|
| 162 |
+
<p class="text-gray-500">
|
| 163 |
+
Base para f谩rmacos contra diabetes tipo 2 y obesidad como exenatida y liraglutida.
|
| 164 |
+
</p>
|
| 165 |
</div>
|
| 166 |
</div>
|
|
|
|
|
|
|
|
|
|
| 167 |
</div>
|
| 168 |
</div>
|
| 169 |
+
</div>
|
| 170 |
+
|
| 171 |
+
<!-- Functions Section -->
|
| 172 |
+
<div id="functions" class="bg-gray-50 py-16">
|
| 173 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 174 |
+
<div class="lg:text-center mb-12">
|
| 175 |
+
<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Roles fisiol贸gicos</h2>
|
| 176 |
+
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
|
| 177 |
+
Funciones clave de GLP-1
|
| 178 |
+
</p>
|
| 179 |
+
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
|
| 180 |
+
El GLP-1 ejerce m煤ltiples efectos en diferentes 贸rganos del cuerpo humano.
|
| 181 |
+
</p>
|
| 182 |
+
</div>
|
| 183 |
|
| 184 |
+
<div class="mt-10">
|
| 185 |
+
<div class="space-y-10 md:space-y-0 md:grid md:grid-cols-2 md:gap-x-8 md:gap-y-12">
|
| 186 |
+
<!-- Function 1 -->
|
| 187 |
+
<div class="relative group">
|
| 188 |
+
<div class="absolute -inset-1 bg-gradient-to-r from-indigo-500 to-indigo-300 rounded-lg blur opacity-25 group-hover:opacity-100 transition duration-500"></div>
|
| 189 |
+
<div class="relative bg-white rounded-lg p-6 h-full card-hover">
|
| 190 |
+
<div class="flex items-center">
|
| 191 |
+
<div class="flex-shrink-0 bg-indigo-500 rounded-md p-3 text-white">
|
| 192 |
+
<i class="fas fa-syringe text-xl"></i>
|
|
|
|
| 193 |
</div>
|
| 194 |
+
<div class="ml-4">
|
| 195 |
+
<h3 class="text-lg font-medium text-gray-900">P谩ncreas</h3>
|
|
|
|
| 196 |
</div>
|
| 197 |
</div>
|
| 198 |
+
<div class="mt-4">
|
| 199 |
+
<p class="text-gray-600">
|
| 200 |
+
- Estimula la secreci贸n de insulina dependiente de glucosa<br>
|
| 201 |
+
- Inhibe la liberaci贸n de glucag贸n<br>
|
| 202 |
+
- Promueve la proliferaci贸n de c茅lulas 尾<br>
|
| 203 |
+
- Reduce la apoptosis de c茅lulas 尾
|
| 204 |
+
</p>
|
| 205 |
+
</div>
|
| 206 |
</div>
|
| 207 |
+
</div>
|
| 208 |
+
|
| 209 |
+
<!-- Function 2 -->
|
| 210 |
+
<div class="relative group">
|
| 211 |
+
<div class="absolute -inset-1 bg-gradient-to-r from-amber-500 to-amber-300 rounded-lg blur opacity-25 group-hover:opacity-100 transition duration-500"></div>
|
| 212 |
+
<div class="relative bg-white rounded-lg p-6 h-full card-hover">
|
| 213 |
+
<div class="flex items-center">
|
| 214 |
+
<div class="flex-shrink-0 bg-amber-500 rounded-md p-3 text-white">
|
| 215 |
+
<i class="fas fa-weight text-xl"></i>
|
| 216 |
</div>
|
| 217 |
+
<div class="ml-4">
|
| 218 |
+
<h3 class="text-lg font-medium text-gray-900">Sistema nervioso</h3>
|
|
|
|
| 219 |
</div>
|
| 220 |
</div>
|
| 221 |
+
<div class="mt-4">
|
| 222 |
+
<p class="text-gray-600">
|
| 223 |
+
- Suprime el apetito al actuar sobre n煤cleos hipotal谩micos<br>
|
| 224 |
+
- Induce saciedad<br>
|
| 225 |
+
- Regula preferencias alimentarias<br>
|
| 226 |
+
- Reducel consumo de alimentos
|
| 227 |
+
</p>
|
| 228 |
+
</div>
|
| 229 |
</div>
|
| 230 |
</div>
|
| 231 |
+
|
| 232 |
+
<!-- Function 3 -->
|
| 233 |
+
<div class="relative group">
|
| 234 |
+
<div class="absolute -inset-1 bg-gradient-to-r from-emerald-500 to-emerald-300 rounded-lg blur opacity-25 group-hover:opacity-100 transition duration-500"></div>
|
| 235 |
+
<div class="relative bg-white rounded-lg p-6 h-full card-hover">
|
| 236 |
+
<div class="flex items-center">
|
| 237 |
+
<div class="flex-shrink-0 bg-emerald-500 rounded-md p-3 text-white">
|
| 238 |
+
<i class="fas fa-heart text-xl"></i>
|
| 239 |
</div>
|
| 240 |
+
<div class="ml-4">
|
| 241 |
+
<h3 class="text-lg font-medium text-gray-900">Tracto gastrointestinal</h3>
|
|
|
|
| 242 |
</div>
|
| 243 |
</div>
|
| 244 |
+
<div class="mt-4">
|
| 245 |
+
<p class="text-gray-600">
|
| 246 |
+
- Retrasa el vaciamiento g谩strico<br>
|
| 247 |
+
- Reduce la motilidad intestinal<br>
|
| 248 |
+
- Disminuye la absorci贸n de nutrientes<br>
|
| 249 |
+
- Puede tener efectos protectores sobre la mucosa
|
| 250 |
+
</p>
|
| 251 |
+
</div>
|
| 252 |
</div>
|
| 253 |
+
</div>
|
| 254 |
+
|
| 255 |
+
<!-- Function 4 -->
|
| 256 |
+
<div class="relative group">
|
| 257 |
+
<div class="absolute -inset-1 bg-gradient-to-r from-purple-500 to-purple-300 rounded-lg blur opacity-25 group-hover:opacity-100 transition duration-500"></div>
|
| 258 |
+
<div class="relative bg-white rounded-lg p-6 h-full card-hover">
|
| 259 |
+
<div class="flex items-center">
|
| 260 |
+
<div class="flex-shrink-0 bg-purple-500 rounded-md p-3 text-white">
|
| 261 |
+
<i class="fas fa-heartbeat text-xl"></i>
|
| 262 |
</div>
|
| 263 |
+
<div class="ml-4">
|
| 264 |
+
<h3 class="text-lg font-medium text-gray-900">Sistema cardiovascular</h3>
|
|
|
|
| 265 |
</div>
|
| 266 |
</div>
|
| 267 |
+
<div class="mt-4">
|
| 268 |
+
<p class="text-gray-600">
|
| 269 |
+
- Mejora la funci贸n endotelial<br>
|
| 270 |
+
- Efectos cardioprotectores<br>
|
| 271 |
+
- Reduce la presi贸n arterial<br>
|
| 272 |
+
- Disminuye la inflamaci贸n vascular
|
| 273 |
+
</p>
|
| 274 |
+
</div>
|
| 275 |
</div>
|
| 276 |
</div>
|
| 277 |
</div>
|
| 278 |
</div>
|
| 279 |
</div>
|
| 280 |
+
</div>
|
| 281 |
|
| 282 |
+
<!-- Research Section -->
|
| 283 |
+
<div id="research" class="bg-white py-16">
|
| 284 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 285 |
+
<div class="lg:text-center">
|
| 286 |
+
<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Avances cient铆ficos</h2>
|
| 287 |
+
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
|
| 288 |
+
Investigaci贸n sobre GLP-1
|
| 289 |
+
</p>
|
| 290 |
+
<p class="mt-4 max-w-2xl text-xl text-gray-500 lg:mx-auto">
|
| 291 |
+
Descubrimientos recientes y direcciones futuras de investigaci贸n.
|
| 292 |
+
</p>
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
|
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|
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|
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|
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|
|
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|
|
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|
|
|
|
|
|
|
|
|
|
| 293 |
</div>
|
|
|
|
| 294 |
|
| 295 |
+
<div class="mt-12">
|
| 296 |
+
<div class="bg-gray-50 rounded-xl p-8 md:p-12 shadow-inner">
|
| 297 |
+
<div class="grid grid-cols-1 md:grid-cols-2 gap-8">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 298 |
<div>
|
| 299 |
+
<h3 class="text-lg font-medium text-indigo-600 mb-4">Mecanismos de acci贸n</h3>
|
| 300 |
+
<ul class="space-y-4">
|
| 301 |
+
<li class="flex items-start">
|
| 302 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 303 |
+
<i class="fas fa-check text-xs"></i>
|
| 304 |
+
</span>
|
| 305 |
+
<p class="ml-3 text-gray-600">Receptor GLP-1 acoplado a prote铆na G (GLP-1R) distribuido en m煤ltiples 贸rganos</p>
|
| 306 |
+
</li>
|
| 307 |
+
<li class="flex items-start">
|
| 308 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 309 |
+
<i class="fas fa-check text-xs"></i>
|
| 310 |
+
</span>
|
| 311 |
+
<p class="ml-3 text-gray-600">Activaci贸n de AMPK y otras v铆as intracelulares</p>
|
| 312 |
+
</li>
|
| 313 |
+
<li class="flex items-start">
|
| 314 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 315 |
+
<i class="fas fa-check text-xs"></i>
|
| 316 |
+
</span>
|
| 317 |
+
<p class="ml-3 text-gray-600">Influencia en la plasticidad sin谩ptica neuronal</p>
|
| 318 |
+
</li>
|
| 319 |
+
</ul>
|
| 320 |
</div>
|
| 321 |
<div>
|
| 322 |
+
<h3 class="text-lg font-medium text-indigo-600 mb-4">脕reas prometedoras</h3>
|
| 323 |
+
<ul class="space-y-4">
|
| 324 |
+
<li class="flex items-start">
|
| 325 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 326 |
+
<i class="fas fa-brain text-xs"></i>
|
| 327 |
+
</span>
|
| 328 |
+
<p class="ml-3 text-gray-600">Potencial en enfermedades neurodegenerativas</p>
|
| 329 |
+
</li>
|
| 330 |
+
<li class="flex items-start">
|
| 331 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 332 |
+
<i class="fas fa-heart text-xs"></i>
|
| 333 |
+
</span>
|
| 334 |
+
<p class="ml-3 text-gray-600">Efectos cardioprotectores en insuficiencia card铆aca</p>
|
| 335 |
+
</li>
|
| 336 |
+
<li class="flex items-start">
|
| 337 |
+
<span class="flex-shrink-0 h-6 w-6 bg-indigo-100 rounded-full flex items-center justify-center text-indigo-600">
|
| 338 |
+
<i class="fas fa-weight text-xs"></i>
|
| 339 |
+
</span>
|
| 340 |
+
<p class="ml-3 text-gray-600">Nuevos an谩logos con mayor duraci贸n de acci贸n</p>
|
| 341 |
+
</li>
|
| 342 |
+
</ul>
|
| 343 |
</div>
|
| 344 |
</div>
|
| 345 |
+
|
| 346 |
+
<div class="mt-10 bg-white p-6 rounded-lg shadow-sm border border-gray-100">
|
| 347 |
+
<div class="flex">
|
| 348 |
+
<div class="flex-shrink-0">
|
| 349 |
+
<i class="fas fa-flask text-indigo-500 text-2xl"></i>
|
| 350 |
+
</div>
|
| 351 |
+
<div class="ml-4">
|
| 352 |
+
<h4 class="text-lg font-medium text-gray-900">Impacto en diabetes tipo 2</h4>
|
| 353 |
+
<p class="mt-2 text-gray-600">
|
| 354 |
+
Los an谩logos de GLP-1 han revolucionado el tratamiento de la diabetes tipo 2, no solo mejorando el control gluc茅mico sino tambi茅n promoviendo la p茅rdida de peso y mostrando efectos protectores cardiovasculares en ensayos cl铆nicos.
|
| 355 |
+
</p>
|
| 356 |
+
</div>
|
| 357 |
</div>
|
| 358 |
</div>
|
| 359 |
</div>
|
| 360 |
</div>
|
| 361 |
</div>
|
| 362 |
+
</div>
|
| 363 |
+
|
| 364 |
+
<!-- Applications Section -->
|
| 365 |
+
<div id="applications" class="bg-indigo-50 py-16">
|
| 366 |
+
<div class="max-w-7xl mx-auto px-4 sm:px-6 lg:px-8">
|
| 367 |
+
<div class="text-center">
|
| 368 |
+
<h2 class="text-base text-indigo-600 font-semibold tracking-wide uppercase">Usos terap茅uticos</h2>
|
| 369 |
+
<p class="mt-2 text-3xl leading-8 font-extrabold tracking-tight text-gray-900 sm:text-4xl">
|
| 370 |
+
Aplicaciones cl铆nicas de GLP-1
|
| 371 |
+
</p>
|
| 372 |
+
<p class="mt-4 max-w-2xl text-xl text-gray-500 mx-auto">
|
| 373 |
+
Terapias basadas en GLP-1 para diversas condiciones m茅dicas.
|
| 374 |
+
</p>
|
| 375 |
+
</div>
|
| 376 |
|
| 377 |
+
<div class="mt-12">
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| 378 |
+
<div class="grid grid-cols-1 gap-8 sm:grid-cols-2 lg:grid-cols-3">
|
| 379 |
+
<!-- App 1 -->
|
| 380 |
+
<div class="pt-6">
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| 381 |
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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<div class="-mt-6">
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| 383 |
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<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
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| 384 |
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<i class="fas fa-vial text-xl"></i>
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| 385 |
+
</div>
|
| 386 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Diabetes Mellitus Tipo 2</h3>
|
| 387 |
+
<p class="mt-5 text-base text-gray-500">
|
| 388 |
+
An谩logos de GLP-1 como exenatida, liraglutida, dulaglutida, y semaglutida mejoran el control gluc茅mico con bajo riesgo de hipoglucemia.
|
| 389 |
+
</p>
|
| 390 |
</div>
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</div>
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<!-- App 2 -->
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<div class="pt-6">
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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<div class="-mt-6">
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<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
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<i class="fas fa-weight text-xl"></i>
|
| 400 |
+
</div>
|
| 401 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Obesidad</h3>
|
| 402 |
+
<p class="mt-5 text-base text-gray-500">
|
| 403 |
+
Liraglutida y semaglutida en dosis m谩s altas est谩n aprobadas para el tratamiento de la obesidad, mostrando reducciones significativas de peso.
|
| 404 |
+
</p>
|
| 405 |
</div>
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</div>
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</div>
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+
|
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+
<!-- App 3 -->
|
| 410 |
+
<div class="pt-6">
|
| 411 |
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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<div class="-mt-6">
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+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
|
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+
<i class="fas fa-brain text-xl"></i>
|
| 415 |
+
</div>
|
| 416 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Enfermedades Neurodegenerativas</h3>
|
| 417 |
+
<p class="mt-5 text-base text-gray-500">
|
| 418 |
+
En investigaci贸n para enfermedades como Alzheimer y Parkinson, mostrando potencial neuroprotector en modelos animales.
|
| 419 |
+
</p>
|
| 420 |
</div>
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+
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<!-- App 4 -->
|
| 425 |
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<div class="pt-6">
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| 426 |
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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+
<div class="-mt-6">
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| 428 |
+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
|
| 429 |
+
<i class="fas fa-heart text-xl"></i>
|
| 430 |
+
</div>
|
| 431 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">Enfermedad Cardiovascular</h3>
|
| 432 |
+
<p class="mt-5 text-base text-gray-500">
|
| 433 |
+
Algunos an谩logos han demostrado reducir eventos cardiovasculares mayores en pacientes con diabetes y enfermedad cardiovascular establecida.
|
| 434 |
+
</p>
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<!-- App 5 -->
|
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<div class="pt-6">
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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+
<div class="-mt-6">
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+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
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<i class="fas fa-pills text-xl"></i>
|
| 445 |
+
</div>
|
| 446 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">S铆ndrome Metab贸lico</h3>
|
| 447 |
+
<p class="mt-5 text-base text-gray-500">
|
| 448 |
+
Beneficios sobre m煤ltiples componentes del s铆ndrome metab贸lico, incluyendo resistencia a la insulina, obesidad abdominal y dislipidemia.
|
| 449 |
+
</p>
|
| 450 |
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<!-- App 6 -->
|
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<div class="pt-6">
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<div class="flow-root bg-white rounded-lg px-6 pb-8 h-full shadow-sm card-hover">
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+
<div class="-mt-6">
|
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+
<div class="flex items-center justify-center h-12 w-12 rounded-md bg-indigo-500 text-white mx-auto">
|
| 459 |
+
<i class="fas fa-liver text-xl"></i>
|
| 460 |
+
</div>
|
| 461 |
+
<h3 class="mt-8 text-lg font-medium text-gray-900 tracking-tight">EHNA (Esteatohepatitis No Alcoh贸lica)</h3>
|
| 462 |
+
<p class="mt-5 text-base text-gray-500">
|
| 463 |
+
Estudios en curso analizan su potencial para reducir la inflamaci贸n y fibrosis hep谩tica en pacientes con EHNA.
|
| 464 |
+
</p>
|
| 465 |
+
</div>
|
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</div>
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</div>
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</div>
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|
| 473 |
+
<!-- Comparison Table -->
|
| 474 |
+
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| 475 |
+
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| 476 |
+
<div class="sm:flex sm:items-center">
|
| 477 |
+
<div class="sm:flex-auto">
|
| 478 |
+
<h2 class="text-xl font-semibold text-gray-900">Comparaci贸n de an谩logos de GLP-1</h2>
|
| 479 |
+
<p class="mt-2 text-sm text-gray-600">
|
| 480 |
+
Principales caracter铆sticas de los f谩rmacos basados en GLP-1 disponibles actualmente.
|
| 481 |
+
</p>
|
| 482 |
+
</div>
|
| 483 |
+
</div>
|
| 484 |
+
<div class="mt-8 flex flex-col">
|
| 485 |
+
<div class="-my-2 -mx-4 overflow-x-auto sm:-mx-6 lg:-mx-8">
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| 486 |
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<div class="inline-block min-w-full py-2 align-middle md:px-6 lg:px-8">
|
| 487 |
+
<div class="overflow-hidden shadow ring-1 ring-black ring-opacity-5 md:rounded-lg">
|
| 488 |
+
<table class="min-w-full divide-y divide-gray-300">
|
| 489 |
+
<thead class="bg-gray-50">
|
| 490 |
+
<tr>
|
| 491 |
+
<th scope="col" class="py-3.5 pl-4 pr-3 text-left text-sm font-semibold text-gray-900 sm:pl-6">F谩rmaco</th>
|
| 492 |
+
<th scope="col" class="px-3 py-3.5 text-left text-sm font-semibold text-gray-900">Frecuencia</th>
|
| 493 |
+
<th scope="col" class="px-3 py-3.5 text-left text-sm font-semibold text-gray-900">Aprobaci贸n</th>
|
| 494 |
+
<th scope="col" class="px-3 py-3.5 text-left text-sm font-semibold text-gray-900">Efecto HbA1c</th>
|
| 495 |
+
<th scope="col" class="px-3 py-3.5 text-left text-sm font-semibold text-gray-900">P茅rdida de peso</th>
|
| 496 |
+
</tr>
|
| 497 |
+
</thead>
|
| 498 |
+
<tbody class="divide-y divide-gray-200 bg-white">
|
| 499 |
+
<tr>
|
| 500 |
+
<td class="whitespace-nowrap py-4 pl-4 pr-3 text-sm font-medium text-gray-900 sm:pl-6">Exenatida</td>
|
| 501 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2x/d铆a o 1x/semana</td>
|
| 502 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2005</td>
|
| 503 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-0.7 a -1.3%</td>
|
| 504 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2-3 kg</td>
|
| 505 |
+
</tr>
|
| 506 |
+
<tr>
|
| 507 |
+
<td class="whitespace-nowrap py-4 pl-4 pr-3 text-sm font-medium text-gray-900 sm:pl-6">Liraglutida</td>
|
| 508 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">1x/d铆a</td>
|
| 509 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2009</td>
|
| 510 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-0.8 a -1.5%</td>
|
| 511 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2-4 kg (4.5 kg en obesidad)</td>
|
| 512 |
+
</tr>
|
| 513 |
+
<tr>
|
| 514 |
+
<td class="whitespace-nowrap py-4 pl-4 pr-3 text-sm font-medium text-gray-900 sm:pl-6">Dulaglutida</td>
|
| 515 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">1x/semana</td>
|
| 516 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">2014</td>
|
| 517 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">-1.0 a -1.6%</td>
|
| 518 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-gray-500">1-3 kg</td>
|
| 519 |
+
</tr>
|
| 520 |
+
<tr>
|
| 521 |
+
<td class="whitespace-nowrap py-4 pl-4 pr-3 text-sm font-medium text-indigo-600 sm:pl-6">Semaglutida</td>
|
| 522 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">1x/semana</td>
|
| 523 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">2017</td>
|
| 524 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">-1.5 a -2.0%</td>
|
| 525 |
+
<td class="whitespace-nowrap px-3 py-4 text-sm text-indigo-600">5-10 kg (15% en obesidad)</td>
|
| 526 |
+
</tr>
|
| 527 |
+
</tbody>
|
| 528 |
+
</table>
|
| 529 |
</div>
|
|
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|
| 530 |
</div>
|
| 531 |
</div>
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|
| 532 |
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|
| 533 |
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|
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+
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| 647 |
+
});
|
| 648 |
+
|
| 649 |
+
// Smooth scrolling for anchor links
|
| 650 |
+
document.querySelectorAll('a[href^="#"]').forEach(anchor => {
|
| 651 |
+
anchor.addEventListener('click', function (e) {
|
| 652 |
+
e.preventDefault();
|
| 653 |
+
const targetId = this.getAttribute('href');
|
| 654 |
+
if (targetId === '#') return;
|
| 655 |
+
|
| 656 |
+
const targetElement = document.querySelector(targetId);
|
| 657 |
+
if (targetElement) {
|
| 658 |
+
targetElement.scrollIntoView({
|
| 659 |
+
behavior: 'smooth'
|
| 660 |
+
});
|
| 661 |
+
|
| 662 |
+
// Close mobile menu if open
|
| 663 |
+
const mobileMenu = document.getElementById('mobile-menu');
|
| 664 |
+
if (!mobileMenu.classList.contains('hidden')) {
|
| 665 |
+
mobileMenu.classList.add('hidden');
|
| 666 |
}
|
| 667 |
}
|
| 668 |
});
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|
| 669 |
});
|
| 670 |
</script>
|
| 671 |
<p style="border-radius: 8px; text-align: center; font-size: 12px; color: #fff; margin-top: 16px;position: fixed; left: 8px; bottom: 8px; z-index: 10; background: rgba(0, 0, 0, 0.8); padding: 4px 8px;">Made with <img src="https://enzostvs-deepsite.hf.space/logo.svg" alt="DeepSite Logo" style="width: 16px; height: 16px; vertical-align: middle;display:inline-block;margin-right:3px;filter:brightness(0) invert(1);"><a href="https://enzostvs-deepsite.hf.space" style="color: #fff;text-decoration: underline;" target="_blank" >DeepSite</a> - 馃К <a href="https://enzostvs-deepsite.hf.space?remix=venezianof/ricercheaa" style="color: #fff;text-decoration: underline;" target="_blank" >Remix</a></p></body>
|
prompts.txt
CHANGED
|
@@ -1 +1,3 @@
|
|
| 1 |
-
glp1 plasticita 10slides
|
|
|
|
|
|
|
|
|
| 1 |
+
glp1 plasticita 10slides
|
| 2 |
+
glp1 proteina g
|
| 3 |
+
glp1 proteina g
|