data/GDPa1_v1.2_sequences.csv

antibody_id,antibody_name,vh_protein_sequence,vl_protein_sequence,light_aligned_aho,heavy_aligned_aho,hc_subtype,lc_subtype,hierarchical_cluster_IgG_isotype_stratified_fold
GDPa1-001,abagovomab,QVKLQESGAELARPGASVKLSCKASGYTFTNYWMQWVKQRPGQGLDWIGAIYPGDGNTRYTHKFKGKATLTADKSSSTAYMQLSSLASEDSGVYYCARGEGNYAWFAYWGQGTTVTVSS,DIELTQSPASLSASVGETVTITCQASENIYSYLAWHQQKQGKSPQLLVYNAKTLAGGVSSRFSGSGSGTHFSLKIKSLQPEDFGIYYCQHHYGILPTFGGGTKLEIK,DIELTQSPASLSASVGETVTITCQAS--ENIY------SYLAWHQQKQGKSPQLLVYN--------AKTLAGGVSSRFSGSGSG--THFSLKIKSLQPEDFGIYYCQHHYG-----------------------ILPTFGGGTKLEIK-,QVKLQES-GAELARPGASVKLSCKASG-YTFTN-----YWMQWVKQRPGQGLDWIGAIYPG---DGNTRYTHKFKGKATLTADKSSSTAYMQLSSLASEDSGVYYCARGEGNY--------------------AWFAYWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-002,abituzumab,QVQLQQSGGELAKPGASVKVSCKASGYTFSSFWMHWVRQAPGQGLEWIGYINPRSGYTEYNEIFRDKATMTTDTSTSTAYMELSSLRSEDTAVYYCASFLGRGAMDYWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDISNYLAWYQQKPGKAPKLLIYYTSKIHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQGNTFPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDIS------NYLAWYQQKPGKAPKLLIYY--------TSKIHSGVPSRFSGSGSG--TDYTFTISSLQPEDIATYYCQQGNT-----------------------FPYTFGQGTKVEIK-,QVQLQQS-GGELAKPGASVKVSCKASG-YTFSS-----FWMHWVRQAPGQGLEWIGYINPR---SGYTEYNEIFRDKATMTTDTSTSTAYMELSSLRSEDTAVYYCASFLGR---------------------GAMDYWGQGTTVTVSS,IgG2,Kappa,0
GDPa1-003,abrezekimab,QVTLKESGPVLVKPTETLTLTCTVSGFSLTNYHVQWIRQPPGKALEWLGVMWSDGDTSFNSVLKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARDGTIAAMDYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCLASEDISNYLAWYQQKPGKAPKLLIYHTSRLQDGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYRFPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCLAS--EDIS------NYLAWYQQKPGKAPKLLIYH--------TSRLQDGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQGYR-----------------------FPLTFGGGTKVEIK-,QVTLKES-GPVLVKPTETLTLTCTVSG-FSLTN-----YHVQWIRQPPGKALEWLGVMWS----DGDTSFNSVLKSRLTISRDTSKSQVVLTMTNMDPVDTATYYCARDGTIAA------------------MDYFDYWGQGTLVTVSS,IgG4,Kappa,2
GDPa1-004,abrilumab,QVQLVQSGAEVKKPGASVKVSCKVSGYTLSDLSIHWVRQAPGKGLEWMGGFDPQDGETIYAQKFQGRVTMTEDTSTDTAYMELSSLKSEDTAVYYCATGSSSSWFDPWGQGTLVTVSS,DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQANSFPWTFGQGTKVEIK,DIQMTQSPSSVSASVGDRVTITCRAS--QGIS------SWLAWYQQKPGKAPKLLIYG--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFANYYCQQANS-----------------------FPWTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKVSG-YTLSD-----LSIHWVRQAPGKGLEWMGGFDPQ---DGETIYAQKFQGRVTMTEDTSTDTAYMELSSLKSEDTAVYYCATGSSS---------------------SWFDPWGQGTLVTVSS,IgG2,Kappa,0
GDPa1-005,adalimumab,EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIR------NYLAWYQQKPGKAPKLLIYA--------ASTLQSGVPSRFSGSGSG--TDFTLTISSLQPEDVATYYCQRYNR-----------------------APYTFGQGTKVEIK-,EVQLVES-GGGLVQPGRSLRLSCAASG-FTFDD-----YAMHWVRQAPGKGLEWVSAITWN---SGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLST------------------ASSLDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-006,aducanumab,QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QSIS------SYLNWYQQKPGKAPKLLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSYS-----------------------TPLTFGGGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FAFSS-----YGMHWVRQAPGKGLEWVAVIWFD---GTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGAR---------------RGPYYMDVWGKGTTVTVSS,IgG1,Kappa,0
GDPa1-007,alemtuzumab,QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QNID------KYLNWYQQKPGKAPKLLIYN--------TNNLQTGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCLQHIS-----------------------RPRTFGQGTKVEIK-,QVQLQES-GPGLVRPSQTLSLTCTVSG-FTFTD-----FYMNWVRQPPGRGLEWIGFIRDKA-KGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTA--------------------APFDYWGQGSLVTVSS,IgG1,Kappa,3
GDPa1-008,alirocumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFNNYAMNWVRQAPGKGLDWVSTISGSGGTTNYADSVKGRFIISRDSSKHTLYLQMNSLRAEDTAVYYCAKDSNWGNFDLWGRGTLVTVSS,DIVMTQSPDSLAVSLGERATINCKSSQSVLYRSNNRNFLGWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTPYTFGQGTKLEIK,DIVMTQSPDSLAVSLGERATINCKSS--QSVLYRSNNRNFLGWYQQKPGQPPNLLIYW--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQQYYT-----------------------TPYTFGQGTKLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFNN-----YAMNWVRQAPGKGLDWVSTISGS---GGTTNYADSVKGRFIISRDSSKHTLYLQMNSLRAEDTAVYYCAKDSNW---------------------GNFDLWGRGTLVTVSS,IgG1,Kappa,2
GDPa1-009,amatuximab,QVQLQQSGPELEKPGASVKISCKASGYSFTGYTMNWVKQSHGKSLEWIGLITPYNGASSYNQKFRGKATLTVDKSSSTAYMDLLSLTSEDSAVYFCARGGYDGRGFDYWGSGTPVTVSS,DIELTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDTSKLASGVPGRFSGSGSGNSYSLTISSVEAEDDATYYCQQWSKHPLTFGSGTKVEIK,DIELTQSPAIMSASPGEKVTMTCSAS--SSVS-------YMHWYQQKSGTSPKRWIYD--------TSKLASGVPGRFSGSGSG--NSYSLTISSVEAEDDATYYCQQWSK-----------------------HPLTFGSGTKVEIK-,QVQLQQS-GPELEKPGASVKISCKASG-YSFTG-----YTMNWVKQSHGKSLEWIGLITPY---NGASSYNQKFRGKATLTVDKSSSTAYMDLLSLTSEDSAVYFCARGGYDG--------------------RGFDYWGSGTPVTVSS,IgG1,Kappa,2
GDPa1-010,andecaliximab,QVQLQESGPGLVKPSETLSLTCTVSGFSLLSYGVHWVRQPPGKGLEWLGVIWTGGTTNYNSALMSRFTISKDDSKNTVYLKMNSLKTEDTAIYYCARYYYGMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVRNTVAWYQQKPGKAPKLLIYSSSYRNTGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQHYITPYTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVR------NTVAWYQQKPGKAPKLLIYS--------SSYRNTGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQQHYI-----------------------TPYTFGGGTKVEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-FSLLS-----YGVHWVRQPPGKGLEWLGVIWT----GGTTNYNSALMSRFTISKDDSKNTVYLKMNSLKTEDTAIYYCARYYY-----------------------GMDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-011,anetumab,QVELVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQAPGKGLEWMGIIDPGDSRTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGQLYGGTYMDGWGQGTLVTVSS,DIALTQPASVSGSPGQSITISCTGTSSDIGGYNSVSWYQQHPGKAPKLMIYGVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYDIESATPVFGGGTKLTVL,DIALTQP-ASVSGSPGQSITISCTGTS-SDIGG----YNSVSWYQQHPGKAPKLMIYG--------VNNRPSGVSNRFSGSKSG--NTASLTISGLQAEDEADYYCSSYDIE---------------------SATPVFGGGTKLTVL-,QVELVQS-GAEVKKPGESLKISCKGSG-YSFTS-----YWIGWVRQAPGKGLEWMGIIDPG---DSRTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGQLYG-------------------GTYMDGWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-012,anifrolumab,EVQLVQSGAEVKKPGESLKISCKGSGYIFTNYWIAWVRQMPGKGLESMGIIYPGDSDIRYSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHDIEGFDYWGRGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFFAWYQQKPGQAPRLLIYGASSRATGIPDRLSGSGSGTDFTLTITRLEPEDFAVYYCQQYDSSAITFGQGTRLEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SFFAWYQQKPGQAPRLLIYG--------ASSRATGIPDRLSGSGSG--TDFTLTITRLEPEDFAVYYCQQYDS-----------------------SAITFGQGTRLEIK-,EVQLVQS-GAEVKKPGESLKISCKGSG-YIFTN-----YWIAWVRQMPGKGLESMGIIYPG---DSDIRYSPSFQGQVTISADKSITTAYLQWSSLKASDTAMYYCARHDIE----------------------GFDYWGRGTLVTVSS,IgG1,Kappa,3
GDPa1-013,anrukinzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFISYAMSWVRQAPGKGLEWVASISSGGNTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLDGYYFGFAYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASESVDNYGKSLMHWYQQKPGKAPKLLIYRASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPWTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--ESVDNY--GKSLMHWYQQKPGKAPKLLIYR--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSNE-----------------------DPWTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFIS-----YAMSWVRQAPGKGLEWVASISS----GGNTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLDGYY--------------------FGFAYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-014,atezolizumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDVS------TAVAWYQQKPGKAPKLLIYS--------ASFLYSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYLY-----------------------HPATFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSD-----SWIHWVRQAPGKGLEWVAWISPY---GGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWP---------------------GGFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-015,avelumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSS,QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVL,QSALTQP-ASVSGSPGQSITISCTGTS-SDVGG----YNYVSWYQQHPGKAPKLMIYD--------VSNRPSGVSNRFSGSKSG--NTASLTISGLQAEDEADYYCSSYTSS----------------------STRVFGTGTKVTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YIMMWVRQAPGKGLEWVSSIYPS---GGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGT-------------------VTTVDYWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-016,bapineuzumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCVRYDHYSGSSDYWGQGTLVTVSS,DVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIK,DVVMTQSPLSLPVTPGEPASISCKSS--QSLLDSD-GKTYLNWLLQKPGQSPQRLIYL--------VSKLDSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCWQGTH-----------------------FPRTFGQGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSN-----YGMSWVRQAPGKGLEWVASIRSG---GGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCVRYDHYS--------------------GSSDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-017,basiliximab,QVQLQQSGTVLARPGASVKMSCKASGYSFTRYWMHWIKQRPGQGLEWIGAIYPGNSDTSYNQKFEGKAKLTAVTSASTAYMELSSLTHEDSAVYYCSRDYGYYFDFWGQGTTLTVSS,QIVSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCHQRSSYTFGGGTKLEIK,QIVSTQSPAIMSASPGEKVTMTCSAS--SSRS-------YMQWYQQKPGTSPKRWIYD--------TSKLASGVPARFSGSGSG--TSYSLTISSMEAEDAATYYCHQRS-------------------------SYTFGGGTKLEIK-,QVQLQQS-GTVLARPGASVKMSCKASG-YSFTR-----YWMHWIKQRPGQGLEWIGAIYPG---NSDTSYNQKFEGKAKLTAVTSASTAYMELSSLTHEDSAVYYCSRDYGY----------------------YFDFWGQGTTLTVSS,IgG1,Kappa,2
GDPa1-018,bavituximab,EVQLQQSGPELEKPGASVKLSCKASGYSFTGYNMNWVKQSHGKSLEWIGHIDPYYGDTSYNQKFRGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCVKGGYYGHWYFDVWGAGTTVTVSS,DIQMTQSPSSLSASLGERVSLTCRASQDIGSSLNWLQQGPDGTIKRLIYATSSLDSGVPKRFSGSRSGSDYSLTISSLESEDFVDYYCLQYVSSPPTFGAGTKLELK,DIQMTQSPSSLSASLGERVSLTCRAS--QDIG------SSLNWLQQGPDGTIKRLIYA--------TSSLDSGVPKRFSGSRSG--SDYSLTISSLESEDFVDYYCLQYVS-----------------------SPPTFGAGTKLELK-,EVQLQQS-GPELEKPGASVKLSCKASG-YSFTG-----YNMNWVKQSHGKSLEWIGHIDPY---YGDTSYNQKFRGKATLTVDKSSSTAYMQLKSLTSEDSAVYYCVKGGYYG-------------------HWYFDVWGAGTTVTVSS,IgG1,Kappa,2
GDPa1-019,belantamab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYWMHWVRQAPGQGLEWMGATYRGHSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDGYDVLDNWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKLLIYYTSNLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYRKLPWTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCSAS--QDIS------NYLNWYQQKPGKAPKLLIYY--------TSNLHSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYRK-----------------------LPWTFGQGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSN-----YWMHWVRQAPGQGLEWMGATYRG---HSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDG------------------YDVLDNWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-020,belimumab,QVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSS,SSELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVL,SSELTQD-PAVSVALGQTVRVTCQGD---SLRS-----YYASWYQQKPGQAPVLVIYG--------KNNRPSGIPDRFSGSSSG--NTASLTITGAQAEDEADYYCSSRDSS---------------------GNHWVFGGGTELTVL-,QVQLQQS-GAEVKKPGSSVRVSCKASG-GTFNN-----NAINWVRQAPGQGLEWMGGIIPM---FGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLF----------------PHHALSPWGRGTMVTVSS,IgG1,Lambda,4
GDPa1-021,bemarituzumab,QVQLVQSGAEVKKPGSSVKVSCKASGYIFTTYNVHWVRQAPGQGLEWIGSIYPDNGDTSYNQNFKGRATITADKSTSTAYMELSSLRSEDTAVYYCARGDFAYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQGVSNDVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHSTTPYTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QGVS------NDVAWYQQKPGKAPKLLIYS--------ASYRYTGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCQQHST-----------------------TPYTFGQGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YIFTT-----YNVHWVRQAPGQGLEWIGSIYPD---NGDTSYNQNFKGRATITADKSTSTAYMELSSLRSEDTAVYYCARGD-------------------------FAYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-022,benralizumab,EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYVIHWVRQRPGQGLAWMGYINPYNDGTKYNERFKGKVTITSDRSTSTVYMELSSLRSEDTAVYLCGREGIRYYGLLGDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCGTSEDIINYLNWYQQKPGKAPKLLIYHTSRLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYTLPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCGTS--EDII------NYLNWYQQKPGKAPKLLIYH--------TSRLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQGYT-----------------------LPYTFGQGTKVEIK-,EVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YVIHWVRQRPGQGLAWMGYINPY---NDGTKYNERFKGKVTITSDRSTSTVYMELSSLRSEDTAVYLCGREGIRYY------------------GLLGDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-023,bevacizumab,EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCSAS--QDIS------NYLNWYQQKPGKAPKVLIYF--------TSSLHSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYST-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YTFTN-----YGMNWVRQAPGKGLEWVGWINTY---TGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGS----------------SHWYFDVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-024,bezlotoxumab,EVQLVQSGAEVKKSGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIFYPGDSSTRYSPSFQGQVTISADKSVNTAYLQWSSLKASDTAMYYCARRRNWGNAFDIWGQGTMVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSTWTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------STWTFGQGTKVEIK-,EVQLVQS-GAEVKKSGESLKISCKGSG-YSFTS-----YWIGWVRQMPGKGLEWMGIFYPG---DSSTRYSPSFQGQVTISADKSVNTAYLQWSSLKASDTAMYYCARRRNWG--------------------NAFDIWGQGTMVTVSS,IgG1,Kappa,3
GDPa1-025,bimagrumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSSYINWVRQAPGQGLEWMGTINPVSGSTSYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGWFDYWGQGTLVTVSS,QSALTQPASVSGSPGQSITISCTGTSSDVGSYNYVNWYQQHPGKAPKLMIYGVSKRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCGTFAGGSYYGVFGGGTKLTVL,QSALTQP-ASVSGSPGQSITISCTGTS-SDVGS----YNYVNWYQQHPGKAPKLMIYG--------VSKRPSGVSNRFSGSKSG--NTASLTISGLQAEDEADYYCGTFAGG---------------------SYYGVFGGGTKLTVL-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----SYINWVRQAPGQGLEWMGTINPV---SGSTSYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGGW------------------------FDYWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-026,bimekizumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSS,AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIK,AIQLTQSPSSLSASVGDRVTITCRAD--ESVR------TLMHWYQQKPGKAPKLLIYL--------VSNSEIGVPDRFSGSGSG--TDFRLTISSLQPEDFATYYCQQTWS-----------------------DPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSD-----YNMAWVRQAPGKGLEWVATITYE---GRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGS--------------IYRLWFAHWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-027,bleselumab,QLQLQESGPGLLKPSETLSLTCTVSGGSISSPGYYGGWIRQPPGKGLEWIGSIYKSGSTYHNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCTRPVVRYFGWFDPWGQGTLVTVSS,AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPTFGQGTKVEIK,AIQLTQSPSSLSASVGDRVTITCRAS--QGIS------SALAWYQQKPGKAPKLLIYD--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQFNS------------------------YPTFGQGTKVEIK-,QLQLQES-GPGLLKPSETLSLTCTVSG-GSISSP---GYYGGWIRQPPGKGLEWIGSIYK----SGSTYHNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCTRPVVRY-------------------FGWFDPWGQGTLVTVSS,IgG4,Kappa,2
GDPa1-028,blosozumab,QVQLVQSGAEVKKPGASVKVSCKVSGFPIKDTFQHWVRQAPGKGLEWMGWSDPEIGDTEYASKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGDTTYKFDFWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVHTAVAWYQQKPGKAPKLLIYWASTRWTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSDYPWTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVH------TAVAWYQQKPGKAPKLLIYW--------ASTRWTGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYSD-----------------------YPWTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKVSG-FPIKD-----TFQHWVRQAPGKGLEWMGWSDPE---IGDTEYASKFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCATGDTT---------------------YKFDFWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-029,bococizumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGEISPFGGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPLYASDLWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQRYSLWRTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIS------SALAWYQQKPGKAPKLLIYS--------ASYRYTGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCQQRYS-----------------------LWRTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YYMHWVRQAPGQGLEWMGEISPF---GGRTNYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARERPL---------------------YASDLWGQGTTVTVSS,IgG2,Kappa,0
GDPa1-030,brazikumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNEYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGYTSSWYPDAFDIWGQGTMVTVSS,QSVLTQPPSVSGAPGQRVTISCTGSSSNTGAGYDVHWYQQVPGTAPKLLIYGSGNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVL,QSVLTQP-PSVSGAPGQRVTISCTGSS-SNTGA----GYDVHWYQQVPGTAPKLLIYG--------SGNRPSGVPDRFSGSKSG--TSASLAITGLQAEDEADYYCQSYDSS---------------------LSGWVFGGGTRLTVL-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAVIWYD---GSNEYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGYTSS---------------WYPDAFDIWGQGTMVTVSS,IgG1,Lambda,4
GDPa1-031,brentuximab,QIQLQQSGPEVVKPGASVKISCKASGYTFTDYYITWVKQKPGQGLEWIGWIYPGSGNTKYNEKFKGKATLTVDTSSSTAFMQLSSLTSEDTAVYFCANYGNYWFAYWGQGTQVTVSA,DIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKVLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPWTFGGGTKLEIK,DIVLTQSPASLAVSLGQRATISCKAS--QSVDFD--GDSYMNWYQQKPGQPPKVLIYA--------ASNLESGIPARFSGSGSG--TDFTLNIHPVEEEDAATYYCQQSNE-----------------------DPWTFGGGTKLEIK-,QIQLQQS-GPEVVKPGASVKISCKASG-YTFTD-----YYITWVKQKPGQGLEWIGWIYPG---SGNTKYNEKFKGKATLTVDTSSSTAFMQLSSLTSEDTAVYFCANYGNY----------------------WFAYWGQGTQVTVSA,IgG1,Kappa,4
GDPa1-032,briakinumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIRYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCKTHGSHDNWGQGTMVTVSS,QSVLTQPPSVSGAPGQRVTISCSGSRSNIGSNTVKWYQQLPGTAPKLLIYYNDQRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDRYTHPALLFGTGTKVTVL,QSVLTQP-PSVSGAPGQRVTISCSGSR-SNIGS-----NTVKWYQQLPGTAPKLLIYY--------NDQRPSGVPDRFSGSKSG--TSASLAITGLQAEDEADYYCQSYDRYT--------------------HPALLFGTGTKVTVL-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAFIRYD---GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCKTHGS------------------------HDNWGQGTMVTVSS,IgG1,Lambda,4
GDPa1-033,brodalumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYGISWVRQAPGQGLEWMGWISTYSGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARRQLYFDYWGQGTLVTVSS,EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWFQQKPGQAPRPLIYDASTRATGVPARFSGSGSGTDFTLTISSLQSEDFAVYYCQQYDNWPLTFGGGTKVEIK,EIVMTQSPATLSVSPGERATLSCRAS--QSVS------SNLAWFQQKPGQAPRPLIYD--------ASTRATGVPARFSGSGSG--TDFTLTISSLQSEDFAVYYCQQYDN-----------------------WPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTR-----YGISWVRQAPGQGLEWMGWISTY---SGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARRQL-----------------------YFDYWGQGTLVTVSS,IgG2,Kappa,2
GDPa1-034,brontictuzumab,QVQLVQSGAEVKKPGASVKISCKVSGYTLRGYWIEWVRQAPGKGLEWIGQILPGTGRTNYNEKFKGRVTMTADTSTDTAYMELSSLRSEDTAVYYCARFDGNYGYYAMDYWGQGTTVTVSS,QAVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWFQQKPGQAPRTLIGGTNNRAPGVPARFSGSLLGGKAALTLSGAQPEDEAEYYCALWYSNHWVFGGGTKLTVL,QAVVTQE-PSLTVSPGGTVTLTCRSST-GAVTT----SNYANWFQQKPGQAPRTLIGG--------TNNRAPGVPARFSGSLLG--GKAALTLSGAQPEDEAEYYCALWYS-----------------------NHWVFGGGTKLTVL-,QVQLVQS-GAEVKKPGASVKISCKVSG-YTLRG-----YWIEWVRQAPGKGLEWIGQILPG---TGRTNYNEKFKGRVTMTADTSTDTAYMELSSLRSEDTAVYYCARFDGNYG------------------YYAMDYWGQGTTVTVSS,IgG2,Lambda,4
GDPa1-035,budigalimab,EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGWVNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGEGLGFGDWGQGTTVTVSS,DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIPVTFGQGTKLEIK,DVVMTQSPLSLPVTPGEPASISCRSS--QSIVHSH-GDTYLEWYLQKPGQSPQLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSH-----------------------IPVTFGQGTKLEIK-,EIQLVQS-GAEVKKPGSSVKVSCKASG-YTFTH-----YGMNWVRQAPGQGLEWVGWVNTY---TGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGEG---------------------LGFGDWGQGTTVTVSS,IgG1,Kappa,4
GDPa1-036,burosumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHYMHWVRQAPGQGLEWMGIINPISGSTSNAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARDIVDAFDFWGQGTMVTVSS,AIQLTQSPSSLSASVGDRVTITCRASQGISSALVWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNDYFTFGPGTKVDIK,AIQLTQSPSSLSASVGDRVTITCRAS--QGIS------SALVWYQQKPGKAPKLLIYD--------ASSLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQFND------------------------YFTFGPGTKVDIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----HYMHWVRQAPGQGLEWMGIINPI---SGSTSNAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARDIVD----------------------AFDFWGQGTMVTVSS,IgG1,Kappa,1
GDPa1-037,cabiralizumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDNYMIWVRQAPGQGLEWMGDINPYNGGTTFNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARESPYFSNLYVMDYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCKASQSVDYDGDNYMNWYQQKPGQAPRLLIYAASNLESGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHLSNEDLSTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCKAS--QSVDYD--GDNYMNWYQQKPGQAPRLLIYA--------ASNLESGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCHLSNE-----------------------DLSTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFTD-----NYMIWVRQAPGQGLEWMGDINPY---NGGTTFNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARESPYFS-----------------NLYVMDYWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-038,camidanlumab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSRYIINWVRQAPGQGLEWMGRIIPILGVENYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARKDWFDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------SPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSR-----YIINWVRQAPGQGLEWMGRIIPI---LGVENYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARKDW------------------------FDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-039,camrelizumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYMMSWVRQAPGKGLEWVATISGGGANTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLYYFDYWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCLASQTIGTWLTWYQQKPGKAPKLLIYTATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVYSIPWTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCLAS--QTIG------TWLTWYQQKPGKAPKLLIYT--------ATSLADGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQVYS-----------------------IPWTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YMMSWVRQAPGKGLEWVATISGG---GANTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLY-----------------------YFDYWGQGTTVTVSS,IgG4,Kappa,1
GDPa1-040,carlumab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYGISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDGIYGELDFWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSDAYLAWYQQKPGQAPRLLIYDASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYIQLHSFTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVSD-----AYLAWYQQKPGQAPRLLIYD--------ASSRATGVPARFSGSGSG--TDFTLTISSLEPEDFAVYYCHQYIQL----------------------HSFTFGQGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSS-----YGISWVRQAPGQGLEWMGGIIPI---FGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDGIY--------------------GELDFWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-041,cemiplimab,EVQLLESGGVLVQPGGSLRLSCAASGFTFSNFGMTWVRQAPGKGLEWVSGISGGGRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNIYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDSITITCRASLSINTFLNWYQQKPGKAPNLLIYAASSLHGGVPSRFSGSGSGTDFTLTIRTLQPEDFATYYCQQSSNTPFTFGPGTVVDFR,DIQMTQSPSSLSASVGDSITITCRAS--LSIN------TFLNWYQQKPGKAPNLLIYA--------ASSLHGGVPSRFSGSGSG--TDFTLTIRTLQPEDFATYYCQQSSN-----------------------TPFTFGPGTVVDFR-,EVQLLES-GGVLVQPGGSLRLSCAASG-FTFSN-----FGMTWVRQAPGKGLEWVSGISGG---GRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNI----------------------YFDYWGQGTLVTVSS,IgG4,Kappa,1
GDPa1-042,certolizumab,EVQLVESGGGLVQPGGSLRLSCAASGYVFTDYGMNWVRQAPGKGLEWMGWINTYIGEPIYADSVKGRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCARGYRSYAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQNVGTNVAWYQQKPGKAPKALIYSASFLYSGVPYRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPLTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QNVG------TNVAWYQQKPGKAPKALIYS--------ASFLYSGVPYRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYNI-----------------------YPLTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YVFTD-----YGMNWVRQAPGKGLEWMGWINTY---IGEPIYADSVKGRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCARGYRS---------------------YAMDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-043,cetrelimab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFDTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARPGLAAAYDTGSLDYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRNYWPLTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVR------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRNY-----------------------WPLTFGQGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSS-----YAISWVRQAPGQGLEWMGGIIPI---FDTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARPGLAAAY----------------DTGSLDYWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-044,cetuximab,QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSA,DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELK,DILLTQSPVILSVSPGERVSFSCRAS--QSIG------TNIHWYQQRTNGSPRLLIKY--------ASESISGIPSRFSGSGSG--TDFTLSINSVESEDIADYYCQQNNN-----------------------WPTTFGAGTKLELK-,QVQLKQS-GPGLVQPSQSLSITCTVSG-FSLTN-----YGVHWVRQSPGKGLEWLGVIWS----GGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYY-------------------DYEFAYWGQGTLVTVSA,IgG1,Kappa,1
GDPa1-045,cixutumumab,EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARAPLRFLEWSTQDHYYYYYMDVWGKGTTVTVSS,SSELTQDPAVSVALGQTVRITCQGDSLRSYYATWYQQKPGQAPILVIYGENKRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCKSRDGSGQHLVFGGGTKLTVL,SSELTQD-PAVSVALGQTVRITCQGD---SLRS-----YYATWYQQKPGQAPILVIYG--------ENKRPSGIPDRFSGSSSG--NTASLTITGAQAEDEADYYCKSRDGS---------------------GQHLVFGGGTKLTVL-,EVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSS-----YAISWVRQAPGQGLEWMGGIIPI---FGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARAPLRFLEWST---------QDHYYYYYMDVWGKGTTVTVSS,IgG1,Lambda,4
GDPa1-046,clazakizumab,EVQLVESGGGLVQPGGSLRLSCAASGFSLSNYYVTWVRQAPGKGLEWVGIIYGSDETAYATSAIGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDDSSDWDAKFNLWGQGTLVTVSS,AIQMTQSPSSLSASVGDRVTITCQASQSINNELSWYQQKPGKAPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQGYSLRNIDNAFGGGTKVEIK,AIQMTQSPSSLSASVGDRVTITCQAS--QSIN------NELSWYQQKPGKAPKLLIYR--------ASTLASGVPSRFSGSGSG--TDFTLTISSLQPDDFATYYCQQGYSLR--------------------NIDNAFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FSLSN-----YYVTWVRQAPGKGLEWVGIIYG----SDETAYATSAIGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDDSSDW------------------DAKFNLWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-047,codrituzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPGQGLEWMGALDPKTGDTAYSQKFKGRVTLTADKSTSTAYMELSSLTSEDTAVYYCTRFYSYTYWGQGTLVTVSS,DVVMTQSPLSLPVTPGEPASISCRSSQSLVHSNRNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQNTHVPPTFGQGTKLEIK,DVVMTQSPLSLPVTPGEPASISCRSS--QSLVHSN-RNTYLHWYLQKPGQSPQLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCSQNTH-----------------------VPPTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTD-----YEMHWVRQAPGQGLEWMGALDPK---TGDTAYSQKFKGRVTLTADKSTSTAYMELSSLTSEDTAVYYCTRFYS------------------------YTYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-048,coltuximab,QVQLVQPGAEVVKPGASVKLSCKTSGYTFTSNWMHWVKQAPGQGLEWIGEIDPSDSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPYYYAMDYWGQGTSVTVSS,EIVLTQSPAIMSASPGERVTMTCSASSGVNYMHWYQQKPGTSPRRWIYDTSKLASGVPARFSGSGSGTDYSLTISSMEPEDAATYYCHQRGSYTFGGGTKLEIK,EIVLTQSPAIMSASPGERVTMTCSAS--SGVN-------YMHWYQQKPGTSPRRWIYD--------TSKLASGVPARFSGSGSG--TDYSLTISSMEPEDAATYYCHQRG-------------------------SYTFGGGTKLEIK-,QVQLVQP-GAEVVKPGASVKLSCKTSG-YTFTS-----NWMHWVKQAPGQGLEWIGEIDPS---DSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPY-------------------YYAMDYWGQGTSVTVSS,IgG1,Kappa,2
GDPa1-049,concizumab,EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISRSGSYSYFPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGGYDEGDAMDSWGQGTTVTVSS,DIVMTQTPLSLSVTPGQPASISCKSSQSLLESDGKTYLNWYLQKPGQSPQLLIYLVSILDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQATHFPQTFGGGTKVEIK,DIVMTQTPLSLSVTPGQPASISCKSS--QSLLESD-GKTYLNWYLQKPGQSPQLLIYL--------VSILDSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCLQATH-----------------------FPQTFGGGTKVEIK-,EVQLVES-GGGLVKPGGSLRLSCAASG-FTFSN-----YAMSWVRQTPEKRLEWVATISRS---GSYSYFPDSVQGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGGYDE------------------GDAMDSWGQGTTVTVSS,IgG4,Kappa,4
GDPa1-050,crenezumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKGLELVASINSNGGSTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASGDYWGQGTTVTVSS,DIVMTQSPLSLPVTPGEPASISCRSSQSLVYSNGDTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIK,DIVMTQSPLSLPVTPGEPASISCRSS--QSLVYSN-GDTYLHWYLQKPGQSPQLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCSQSTH-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YGMSWVRQAPGKGLELVASINSN---GGSTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASG---------------------------DYWGQGTTVTVSS,IgG4,Kappa,4
GDPa1-051,crizanlizumab,QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYDINWVRQAPGKGLEWMGWIYPGDGSIKYNEKFKGRVTMTVDKSTDTAYMELSSLRSEDTAVYYCARRGEYGNYEGAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQSVDYDGHSYMNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSDENPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QSVDYD--GHSYMNWYQQKPGKAPKLLIYA--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSDE-----------------------NPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKVSG-YTFTS-----YDINWVRQAPGKGLEWMGWIYPG---DGSIKYNEKFKGRVTMTVDKSTDTAYMELSSLRSEDTAVYYCARRGEYGN-----------------YEGAMDYWGQGTLVTVSS,IgG2,Kappa,0
GDPa1-052,cusatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSVYYMNWVRQAPGKGLEWVSDINNEGGTTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCARDAGYSNHVPIFDSWGQGTLVTVSS,QAVVTQEPSLTVSPGGTVTLTCGLKSGSVTSDNFPTWYQQTPGQAPRLLIYNTNTRHSGVPDRFSGSILGNKAALTITGAQADDEAEYFCALFISNPSVEFGGGTQLTVL,QAVVTQE-PSLTVSPGGTVTLTCGLKS-GSVTS----DNFPTWYQQTPGQAPRLLIYN--------TNTRHSGVPDRFSGSILG--NKAALTITGAQADDEAEYFCALFISN----------------------PSVEFGGGTQLTVL-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSV-----YYMNWVRQAPGKGLEWVSDINNE---GGTTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAVYYCARDAGYSN-----------------HVPIFDSWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-053,dacetuzumab,EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYYIHWVRQAPGKGLEWVARVIPNAGGTSYNQKFKGRFTLSVDNSKNTAYLQMNSLRAEDTAVYYCAREGIYWWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRSSQSLVHSNGNTFLHWYQQKPGKAPKLLIYTVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCSQTTHVPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRSS--QSLVHSN-GNTFLHWYQQKPGKAPKLLIYT--------VSNRFSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYFCSQTTH-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YSFTG-----YYIHWVRQAPGKGLEWVARVIPN---AGGTSYNQKFKGRFTLSVDNSKNTAYLQMNSLRAEDTAVYYCAREG-------------------------IYWWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-054,daclizumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYRMHWVRQAPGQGLEWIGYINPSTGYTEYNQKFKDKATITADESTNTAYMELSSLRSEDTAVYYCARGGGVFDYWGQGTLVTVSS,DIQMTQSPSTLSASVGDRVTITCSASSSISYMHWYQQKPGKAPKLLIYTTSNLASGVPARFSGSGSGTEFTLTISSLQPDDFATYYCHQRSTYPLTFGQGTKVEVK,DIQMTQSPSTLSASVGDRVTITCSAS--SSIS-------YMHWYQQKPGKAPKLLIYT--------TSNLASGVPARFSGSGSG--TEFTLTISSLQPDDFATYYCHQRST-----------------------YPLTFGQGTKVEVK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFTS-----YRMHWVRQAPGQGLEWIGYINPS---TGYTEYNQKFKDKATITADESTNTAYMELSSLRSEDTAVYYCARGGG-----------------------VFDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-055,dalotuzumab,QVQLQESGPGLVKPSETLSLTCTVSGYSITGGYLWNWIRQPPGKGLEWIGYISYDGTNNYKPSLKDRVTISRDTSKNQFSLKLSSVTAADTAVYYCARYGRVFFDYWGQGTLVTVSS,DIVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRLYGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIK,DIVMTQSPLSLPVTPGEPASISCRSS--QSIVHSN-GNTYLQWYLQKPGQSPQLLIYK--------VSNRLYGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSH-----------------------VPWTFGQGTKVEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-YSITG----GYLWNWIRQPPGKGLEWIGYISY----DGTNNYKPSLKDRVTISRDTSKNQFSLKLSSVTAADTAVYYCARYGRV----------------------FFDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-056,daratumumab,EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WPPTFGQGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAVSG-FTFNS-----FAMSWVRQAPGKGLEWVSAISGS---GGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWF-----------------GEPVFDYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-057,denosumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVRGRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVFYCQQYGSSPRTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVRG-----RYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVFYCQQYGS-----------------------SPRTFGQGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YAMSWVRQAPGKGLEWVSGITGS---GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTV-----------------IMSWFDPWGQGTLVTVSS,IgG2,Kappa,4
GDPa1-058,depatuxizumab,QVQLQESGPGLVKPSQTLSLTCTVSGYSISSDFAWNWIRQPPGKGLEWMGYISYSGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTAGRGFPYWGQGTLVTVSS,DIQMTQSPSSMSVSVGDRVTITCHSSQDINSNIGWLQQKPGKSFKGLIYHGTNLDDGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCVQYAQFPWTFGGGTKLEIK,DIQMTQSPSSMSVSVGDRVTITCHSS--QDIN------SNIGWLQQKPGKSFKGLIYH--------GTNLDDGVPSRFSGSGSG--TDYTLTISSLQPEDFATYYCVQYAQ-----------------------FPWTFGGGTKLEIK-,QVQLQES-GPGLVKPSQTLSLTCTVSG-YSISS----DFAWNWIRQPPGKGLEWMGYISY----SGNTRYQPSLKSRITISRDTSKNQFFLKLNSVTAADTATYYCVTAGR-----------------------GFPYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-059,dinutuximab,EVQLLQSGPELEKPGASVMISCKASGSSFTGYNMNWVRQNIGKSLEWIGAIDPYYGGTSYNQKFKGRATLTVDKSSSTAYMHLKSLTSEDSAVYYCVSGMEYWGQGTSVTVSS,EIVMTQSPATLSVSPGERATLSCRSSQSLVHRNGNTYLHWYLQKPGQSPKLLIHKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPLTFGAGTKLELK,EIVMTQSPATLSVSPGERATLSCRSS--QSLVHRN-GNTYLHWYLQKPGQSPKLLIHK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDLGVYFCSQSTHV----------------------PPLTFGAGTKLELK-,EVQLLQS-GPELEKPGASVMISCKASG-SSFTG-----YNMNWVRQNIGKSLEWIGAIDPY---YGGTSYNQKFKGRATLTVDKSSSTAYMHLKSLTSEDSAVYYCVSGM--------------------------EYWGQGTSVTVSS,IgG1,Kappa,4
GDPa1-060,domagrozumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSTISSGGSYTSYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKQDYAMNYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHYSTPWTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVS------TAVAWYQQKPGKAPKLLIYS--------ASYRYTGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQHYS-----------------------TPWTFGGGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YAMSWVRQAPGKGLEWVSTISSG---GSYTSYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKQDY-----------------------AMNYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-061,dostarlimab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSS,DIQLTQSPSFLSAYVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTLHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQHYSSYPWTFGQGTKLEIK,DIQLTQSPSFLSAYVGDRVTITCKAS--QDVG------TAVAWYQQKPGKAPKLLIYW--------ASTLHTGVPSRFSGSGSG--TEFTLTISSLQPEDFATYYCQHYSS-----------------------YPWTFGQGTKLEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YDMSWVRQAPGKGLEWVSTISGG---GSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYY-----------------------AMDYWGQGTTVTVSS,IgG4,Kappa,1
GDPa1-062,duligotuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTLSGDWIHWVRQAPGKGLEWVGEISAAGGYTDYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARESRVSFEAAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQNIATDVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSEPEPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QNIA------TDVAWYQQKPGKAPKLLIYS--------ASFLYSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSEP-----------------------EPYTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTLSG-----DWIHWVRQAPGKGLEWVGEISAA---GGYTDYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARESRVSF------------------EAAMDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-063,dupilumab,EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVSS,DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGFYYCMQALQTPYTFGQGTKLEIK,DIVMTQSPLSLPVTPGEPASISCRSS--QSLLYSI-GYNYLDWYLQKSGQSPQLLIYL--------GSNRASGVPDRFSGSGSG--TDFTLKISRVEAEDVGFYYCMQALQ-----------------------TPYTFGQGTKLEIK-,EVQLVES-GGGLEQPGGSLRLSCAGSG-FTFRD-----YAMTWVRQAPGKGLEWVSSISGS---GGNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLSITIR--------------PRYYGLDVWGQGTTVTVSS,IgG4,Kappa,4
GDPa1-064,durvalumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QRVSS-----SYLAWYQQKPGQAPRLLIYD--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------LPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSR-----YWMSWVRQAPGKGLEWVANIKQD---GSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFG------------------ELAFDYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-065,eculizumab,QVQLVQSGAEVKKPGASVKVSCKASGYIFSNYWIQWVRQAPGQGLEWMGEILPGSGSTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSSPNWYFDVWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCGASENIYGALNWYQQKPGKAPKLLIYGATNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQNVLNTPLTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCGAS--ENIY------GALNWYQQKPGKAPKLLIYG--------ATNLADGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQNVLN-----------------------TPLTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YIFSN-----YWIQWVRQAPGQGLEWMGEILPG---SGSTEYTENFKDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARYFFGSS-----------------PNWYFDVWGQGTLVTVSS,IgG2,Kappa,0
GDPa1-066,efalizumab,EVQLVESGGGLVQPGGSLRLSCAASGYSFTGHWMNWVRQAPGKGLEWVGMIHPSDSETRYNQKFKDRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARGIYFYGTTYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASKTISKYLAWYQQKPGKAPKLLIYSGSTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHNEYPLTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--KTIS------KYLAWYQQKPGKAPKLLIYS--------GSTLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQHNE-----------------------YPLTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YSFTG-----HWMNWVRQAPGKGLEWVGMIHPS---DSETRYNQKFKDRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARGIYFYG------------------TTYFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-067,eldelumab,QMQLVESGGGVVQPGRSLRLSCTASGFTFSNNGMHWVRQAPGKGLEWVAVIWFDGMNKFYVDSVKGRFTISRDNSKNTLYLEMNSLRAEDTAIYYCAREGDGSGIYYYYGMDVWGQGTTVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPIFTFGPGTKVDIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGSS----------------------PIFTFGPGTKVDIK-,QMQLVES-GGGVVQPGRSLRLSCTASG-FTFSN-----NGMHWVRQAPGKGLEWVAVIWFD---GMNKFYVDSVKGRFTISRDNSKNTLYLEMNSLRAEDTAIYYCAREGDGSGI---------------YYYYGMDVWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-068,elezanumab,EVQLVQSGAEVKKPGASVKVSCKASGYTFTSHGISWVRQAPGQGLDWMGWISPYSGNTNYAQKLQGRVTMTTDTSTSTAYMELSSLRSEDTAVYYCARVGSGPYYYMDVWGQGTLVTVSS,QSALTQPRSVSGSPGQSVTISCTGTSSSVGDSIYVSWYQQHPGKAPKLMLYDVTKRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCYSYAGTDTLFGGGTKVTVL,QSALTQP-RSVSGSPGQSVTISCTGTS-SSVGD----SIYVSWYQQHPGKAPKLMLYD--------VTKRPSGVPDRFSGSKSG--NTASLTISGLQAEDEADYYCYSYAG-----------------------TDTLFGGGTKVTVL-,EVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----HGISWVRQAPGQGLDWMGWISPY---SGNTNYAQKLQGRVTMTTDTSTSTAYMELSSLRSEDTAVYYCARVGSGP-------------------YYYMDVWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-069,elotuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFDFSRYWMSWVRQAPGKGLEWIGEINPDSSTINYAPSLKDKFIISRDNAKNSLYLQMNSLRAEDTAVYYCARPDGNYWYFDVWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVGIAVAWYQQKPGKVPKLLIYWASTRHTGVPDRFSGSGSGTDFTLTISSLQPEDVATYYCQQYSSYPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVG------IAVAWYQQKPGKVPKLLIYW--------ASTRHTGVPDRFSGSGSG--TDFTLTISSLQPEDVATYYCQQYSS-----------------------YPYTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FDFSR-----YWMSWVRQAPGKGLEWIGEINPD---SSTINYAPSLKDKFIISRDNAKNSLYLQMNSLRAEDTAVYYCARPDGNY--------------------WYFDVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-070,emactuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYDISWVRQAPGQGLEWMGVIWTDGGTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDQRLYFDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASEDVNTYVSWYQQKPGKAPKLLIYAASNRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSFSYPTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--EDVN------TYVSWYQQKPGKAPKLLIYA--------ASNRYTGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSFS------------------------YPTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YDISWVRQAPGQGLEWMGVIWT----DGGTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDQRL----------------------YFDVWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-071,emapalumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDGSSGWYVPHWFDPWGQGTLVTVSS,NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSNRWMFGGGTKLTVL,NFMLTQP-HSVSESPGKTVTISCTRSS-GSIAS-----NYVQWYQQRPGSSPTTVIYE--------DNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGS----------------------NRWMFGGGTKLTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YAMSWVRQAPGKGLEWVSAISGS---GGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDGSSGWY----------------VPHWFDPWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-072,emibetuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGRVNPNRRGTTYNQKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARANWLDYWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCSVSSSVSSIYLHWYQQKPGKAPKLLIYSTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQVYSGYPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCSVS--SSVSS-----IYLHWYQQKPGKAPKLLIYS--------TSNLASGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQVYSG-----------------------YPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTD-----YYMHWVRQAPGQGLEWMGRVNPN---RRGTTYNQKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARANW------------------------LDYWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-073,enavatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAEIRLKSDNYATHYAESVKGRFTISRDDSKNSLYLQMNSLRAEDTAVYYCTGYYADAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKLLIKYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWEIPYTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QSVSTS--SYSYMHWYQQKPGKAPKLLIKY--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQHSWE-----------------------IPYTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YWMSWVRQAPGKGLEWVAEIRLKS-DNYATHYAESVKGRFTISRDDSKNSLYLQMNSLRAEDTAVYYCTGYYAD----------------------AMDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-074,enokizumab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSYYWIEWVRQAPGQGLEWMGEILPGSGTTNPNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARADYYGSDYVKFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQHVITHVTWYQQKPGKAPKLLIYGTSYSYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFYEYPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QHVI------THVTWYQQKPGKAPKLLIYG--------TSYSYSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQFYE-----------------------YPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSY-----YWIEWVRQAPGQGLEWMGEILPG---SGTTNPNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARADYYGS-----------------DYVKFDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-075,epratuzumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFTSYWLHWVRQAPGQGLEWIGYINPRNDYTEYNQNFKDKATITADESTNTAYMELSSLRSEDTAFYFCARRDITTFYWGQGTTVTVSS,DIQLTQSPSSLSASVGDRVTMSCKSSQSVLYSANHKNYLAWYQQKPGKAPKLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCHQYLSSWTFGGGTKLEIK,DIQLTQSPSSLSASVGDRVTMSCKSS--QSVLYSANHKNYLAWYQQKPGKAPKLLIYW--------ASTRESGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCHQYLS------------------------SWTFGGGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFTS-----YWLHWVRQAPGQGLEWIGYINPR---NDYTEYNQNFKDKATITADESTNTAYMELSSLRSEDTAFYFCARRDI-----------------------TTFYWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-076,eptinezumab,EVQLVESGGGLVQPGGSLRLSCAVSGIDLSGYYMNWVRQAPGKGLEWVGVIGINGATYYASWAKGRFTISRDNSKTTVYLQMNSLRAEDTAVYFCARGDIWGQGTLVTVSS,QVLTQSPSSLSASVGDRVTINCQASQSVYHNTYLAWYQQKPGKVPKQLIYDASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLGSYDCTNGDCFVFGGGTKVEIK,-QVLTQSPSSLSASVGDRVTINCQAS--QSVYH----NTYLAWYQQKPGKVPKQLIYD--------ASTLASGVPSRFSGSGSG--TDFTLTISSLQPEDVATYYCLGSYDCT-------------------NGDCFVFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAVSG-IDLSG-----YYMNWVRQAPGKGLEWVGVIGI----NGATYYASWAKGRFTISRDNSKTTVYLQMNSLRAEDTAVYFCARG---------------------------DIWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-077,erenumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAVISFDGSIKYSVDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARDRLNYYDSSGYYHYKYYGMAVWGQGTTVTVSS,QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSTTLGITGLQTGDEADYYCGTWDSRLSAVVFGGGTKLTVL,QSVLTQP-PSVSAAPGQKVTISCSGSS-SNIGN-----NYVSWYQQLPGTAPKLLIYD--------NNKRPSGIPDRFSGSKSG--TSTTLGITGLQTGDEADYYCGTWDSR---------------------LSAVVFGGGTKLTVL-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----FGMHWVRQAPGKGLEWVAVISFD---GSIKYSVDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARDRLNYYDSSG---------YYHYKYYGMAVWGQGTTVTVSS,IgG2,Lambda,3
GDPa1-078,etaracizumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVAKVSSGGGSTYYLDTVQGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARHLHGSFASWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCQASQSISNFLHWYQQRPGQAPRLLIRYRSQSISGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSGSWPLTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCQAS--QSIS------NFLHWYQQRPGQAPRLLIRY--------RSQSISGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQSGS-----------------------WPLTFGGGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YDMSWVRQAPGKGLEWVAKVSSG---GGSTYYLDTVQGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARHLHG----------------------SFASWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-079,etrolizumab,EVQLVESGGGLVQPGGSLRLSCAASGFFITNNYWGWVRQAPGKGLEWVGYISYSGSTSYNPSLKSRFTISRDTSKNTFYLQMNSLRAEDTAVYYCARTGSSGYFDFWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASESVDDLLHWYQQKPGKAPKLLIKYASQSISGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGNSLPNTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--ESVD------DLLHWYQQKPGKAPKLLIKY--------ASQSISGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQGNS-----------------------LPNTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FFITN-----NYWGWVRQAPGKGLEWVGYISY----SGSTSYNPSLKSRFTISRDTSKNTFYLQMNSLRAEDTAVYYCARTGSS---------------------GYFDFWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-080,evinacumab,EVQLVESGGGVIQPGGSLRLSCAASGFTFDDYAMNWVRQGPGKGLEWVSAISGDGGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAFFYCAKDLRNTIFGVVIPDAFDIWGQGTMVTVSS,DIQMTQSPSTLSASVGDRVTITCRASQSIRSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYSYTFGQGTKLEIK,DIQMTQSPSTLSASVGDRVTITCRAS--QSIR------SWLAWYQQKPGKAPKLLIYK--------ASSLESGVPSRFSGSGSG--TEFTLTISSLQPDDFATYYCQQYNS-----------------------YSYTFGQGTKLEIK-,EVQLVES-GGGVIQPGGSLRLSCAASG-FTFDD-----YAMNWVRQGPGKGLEWVSAISGD---GGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRAEDTAFFYCAKDLRNTIFG-------------VVIPDAFDIWGQGTMVTVSS,IgG4,Kappa,1
GDPa1-081,evolocumab,EVQLVQSGAEVKKPGASVKVSCKASGYTLTSYGISWVRQAPGQGLEWMGWVSFYNGNTNYAQKLQGRGTMTTDPSTSTAYMELRSLRSDDTAVYYCARGYGMDVWGQGTTVTVSS,ESALTQPASVSGSPGQSITISCTGTSSDVGGYNSVSWYQQHPGKAPKLMIYEVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCNSYTSTSMVFGGGTKLTVL,ESALTQP-ASVSGSPGQSITISCTGTS-SDVGG----YNSVSWYQQHPGKAPKLMIYE--------VSNRPSGVSNRFSGSKSG--NTASLTISGLQAEDEADYYCNSYTS-----------------------TSMVFGGGTKLTVL-,EVQLVQS-GAEVKKPGASVKVSCKASG-YTLTS-----YGISWVRQAPGQGLEWMGWVSFY---NGNTNYAQKLQGRGTMTTDPSTSTAYMELRSLRSDDTAVYYCARGYG------------------------MDVWGQGTTVTVSS,IgG2,Lambda,3
GDPa1-082,farletuzumab,EVQLVESGGGVVQPGRSLRLSCSASGFTFSGYGLSWVRQAPGKGLEWVAMISSGGSYTYYADSVKGRFAISRDNAKNTLFLQMDSLRPEDTGVYFCARHGDDPAWFAYWGQGTPVTVSS,DIQLTQSPSSLSASVGDRVTITCSVSSSISSNNLHWYQQKPGKAPKPWIYGTSNLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSYPYMYTFGQGTKVEIK,DIQLTQSPSSLSASVGDRVTITCSVS--SSISS-----NNLHWYQQKPGKAPKPWIYG--------TSNLASGVPSRFSGSGSG--TDYTFTISSLQPEDIATYYCQQWSSY---------------------PYMYTFGQGTKVEIK-,EVQLVES-GGGVVQPGRSLRLSCSASG-FTFSG-----YGLSWVRQAPGKGLEWVAMISSG---GSYTYYADSVKGRFAISRDNAKNTLFLQMDSLRPEDTGVYFCARHGDDP--------------------AWFAYWGQGTPVTVSS,IgG1,Kappa,1
GDPa1-083,fasinumab,QVQLVQSGAEVKKPGASVKVSCKVSGFTLTELSIHWVRQAPGKGLEWMGGFDPEDGETIYAQKFQGRVTMTEDTSTDTAYMELTSLRSEDTAVYYCSTIFGVVTNFDNWGQGTLVTVSS,DIQMTQSPSSLSASAGDRVTITCRASQAIRNDLGWYQQKPGKAPKRLIYAAFNLQSGVPSRFSGSGSGTEFTLTISSLQPEDLASYYCQQYNRYPWTFGQGTKVEIK,DIQMTQSPSSLSASAGDRVTITCRAS--QAIR------NDLGWYQQKPGKAPKRLIYA--------AFNLQSGVPSRFSGSGSG--TEFTLTISSLQPEDLASYYCQQYNR-----------------------YPWTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKVSG-FTLTE-----LSIHWVRQAPGKGLEWMGGFDPE---DGETIYAQKFQGRVTMTEDTSTDTAYMELTSLRSEDTAVYYCSTIFGVV--------------------TNFDNWGQGTLVTVSS,IgG4,Kappa,0
GDPa1-084,fezakinumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMHWVRQAPGQGLEWVGWINPYTGSAFYAQKFRGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAREPEKFDSDDSDVWGRGTLVTVSS,QAVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYGVHWYQQLPGTAPKLLIYGDSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDNSLSGYVFGGGTQLTVL,QAVLTQP-PSVSGAPGQRVTISCTGSS-SNIGA----GYGVHWYQQLPGTAPKLLIYG--------DSNRPSGVPDRFSGSKSG--TSASLAITGLQAEDEADYYCQSYDNS---------------------LSGYVFGGGTQLTVL-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----YYMHWVRQAPGQGLEWVGWINPY---TGSAFYAQKFRGRVTMTRDTSISTAYMELSRLRSDDTAVYYCAREPEKFD------------------SDDSDVWGRGTLVTVSS,IgG1,Lambda,4
GDPa1-085,ficlatuzumab,QVQLVQPGAEVKKPGTSVKLSCKASGYTFTTYWMHWVRQAPGQGLEWIGEINPTNGHTNYNQKFQGRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNYVGSIFDYWGQGTLLTVSS,DIVMTQSPDSLAMSLGERVTLNCKASENVVSYVSWYQQKPGQSPKLLIYGASNRESGVPDRFSGSGSATDFTLTISSVQAEDVADYHCGQSYNYPYTFGQGTKLEIK,DIVMTQSPDSLAMSLGERVTLNCKAS--ENVV------SYVSWYQQKPGQSPKLLIYG--------ASNRESGVPDRFSGSGSA--TDFTLTISSVQAEDVADYHCGQSYN-----------------------YPYTFGQGTKLEIK-,QVQLVQP-GAEVKKPGTSVKLSCKASG-YTFTT-----YWMHWVRQAPGQGLEWIGEINPT---NGHTNYNQKFQGRATLTVDKSTSTAYMELSSLRSEDTAVYYCARNYVG---------------------SIFDYWGQGTLLTVSS,IgG1,Kappa,4
GDPa1-086,figitumumab,EVQLLESGGGLVQPGGSLRLSCTASGFTFSSYAMNWVRQAPGKGLEWVSAISGSGGTTFYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDLGWSDSYYYYYGMDVWGQGTTVTVSS,DIQMTQFPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASRLHRGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPCSFGQGTKLEIK,DIQMTQFPSSLSASVGDRVTITCRAS--QGIR------NDLGWYQQKPGKAPKRLIYA--------ASRLHRGVPSRFSGSGSG--TEFTLTISSLQPEDFATYYCLQHNS-----------------------YPCSFGQGTKLEIK-,EVQLLES-GGGLVQPGGSLRLSCTASG-FTFSS-----YAMNWVRQAPGKGLEWVSAISGS---GGTTFYADSVKGRFTISRDNSRTTLYLQMNSLRAEDTAVYYCAKDLGWSDSY--------------YYYYGMDVWGQGTTVTVSS,IgG2,Kappa,2
GDPa1-087,fletikumab,QVQLVQSGAEVKRPGASVKVSCKASGYTFTNDIIHWVRQAPGQRLEWMGWINAGYGNTQYSQNFQDRVSITRDTSASTAYMELISLRSEDTAVYYCAREPLWFGESSPHDYYGMDVWGQGTTVTVSS,AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIK,AIQLTQSPSSLSASVGDRVTITCRAS--QGIS------SALAWYQQKPGKAPKLLIYD--------ASSLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQFNS-----------------------YPLTFGGGTKVEIK-,QVQLVQS-GAEVKRPGASVKVSCKASG-YTFTN-----DIIHWVRQAPGQRLEWMGWINAG---YGNTQYSQNFQDRVSITRDTSASTAYMELISLRSEDTAVYYCAREPLWFGESS------------PHDYYGMDVWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-088,foralumab,QVQLVESGGGVVQPGRSLRLSCAASGFKFSGYGMHWVRQAPGKGLEWVAVIWYDGSKKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQMGYWHFDLWGRGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPLTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSNW----------------------PPLTFGGGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FKFSG-----YGMHWVRQAPGKGLEWVAVIWYD---GSKKYYVDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQMGY---------------------WHFDLWGRGTLVTVSS,IgG1,Kappa,2
GDPa1-089,fremanezumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWISWVRQAPGKGLEWVAEIRSESDASATHYAEAVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCLAYFDYGLAIQNYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCKASKRVTTYVSWYQQKPGQAPRLLIYGASNRYLGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCSQSYNYPYTFGQGTKLEIK,EIVLTQSPATLSLSPGERATLSCKAS--KRVT------TYVSWYQQKPGQAPRLLIYG--------ASNRYLGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCSQSYN-----------------------YPYTFGQGTKLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSN-----YWISWVRQAPGKGLEWVAEIRSES-DASATHYAEAVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCLAYFDYG-------------------LAIQNYWGQGTLVTVSS,IgG2,Kappa,4
GDPa1-090,fresolimumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSNVISWVRQAPGQGLEWMGGVIPIVDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLVLDAMDYWGQGTLVTVSS,ETVLTQSPGTLSLSPGERATLSCRASQSLGSSYLAWYQQKPGQAPRLLIYGASSRAPGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYADSPITFGQGTRLEIK,ETVLTQSPGTLSLSPGERATLSCRAS--QSLGS-----SYLAWYQQKPGQAPRLLIYG--------ASSRAPGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYAD-----------------------SPITFGQGTRLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFSS-----NVISWVRQAPGQGLEWMGGVIPI---VDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLV-------------------LDAMDYWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-091,fulranumab,EVQLVESGGGLVQPGGSLRLSCAASGFTLRSYSMNWVRQAPGKGLEWVSYISRSSHTIFYADSVKGRFTISRDNAKNSLYLQMDSLRDEDTAMYYCARVYSSGWHVSDYFDYWGQGILVTVSS,AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIK,AIQLTQSPSSLSASVGDRVTITCRAS--QGIS------SALAWYQQKPGKAPKLLIYD--------ASSLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQFNS-----------------------YPLTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTLRS-----YSMNWVRQAPGKGLEWVSYISRS---SHTIFYADSVKGRFTISRDNAKNSLYLQMDSLRDEDTAMYYCARVYSSGWH----------------VSDYFDYWGQGILVTVSS,IgG2,Kappa,2
GDPa1-092,galcanezumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFGNYWMQWVRQAPGQGLEWMGAIYEGTGKTVYIQKFADRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSDYVSGFGYWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASKDISKYLNWYQQKPGKAPKLLIYYTSGYHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDALPPTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--KDIS------KYLNWYQQKPGKAPKLLIYY--------TSGYHSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQGDA-----------------------LPPTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFGN-----YWMQWVRQAPGQGLEWMGAIYEG---TGKTVYIQKFADRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSDYV--------------------SGFGYWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-093,galiximab,QVQLQESGPGLVKPSETLSLTCAVSGGSISGGYGWGWIRQPPGKGLEWIGSFYSSSGNTYYNPSLKSQVTISTDTSKNQFSLKLNSMTAADTAVYYCVRDRLFSVVGMVYNNWFDVWGPGVLVTVSS,ESALTQPPSVSGAPGQKVTISCTGSTSNIGGYDLHWYQQLPGTAPKLLIYDINKRPSGISDRFSGSKSGTAASLAITGLQTEDEADYYCQSYDSSLNAQVFGGGTRLTVL,ESALTQP-PSVSGAPGQKVTISCTGST-SNIGG-----YDLHWYQQLPGTAPKLLIYD--------INKRPSGISDRFSGSKSG--TAASLAITGLQTEDEADYYCQSYDSS---------------------LNAQVFGGGTRLTVL-,QVQLQES-GPGLVKPSETLSLTCAVSG-GSISG----GYGWGWIRQPPGKGLEWIGSFYSS---SGNTYYNPSLKSQVTISTDTSKNQFSLKLNSMTAADTAVYYCVRDRLFSVVG-------------MVYNNWFDVWGPGVLVTVSS,IgG1,Lambda,4
GDPa1-094,ganitumab,QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRTDAFDIWGQGTMVTVSS,DVVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGQGTKVEIK,DVVMTQSPLSLPVTPGEPASISCRSS--QSLLHSN-GYNYLDWYLQKPGQSPQLLIYL--------GSNRASGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCMQGTH-----------------------WPLTFGQGTKVEIK-,QVQLQES-GPGLVKPSGTLSLTCAVSG-GSISS----SNWWSWVRQPPGKGLEWIGEIYH----SGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARWTGRT--------------------DAFDIWGQGTMVTVSS,IgG1,Kappa,3
GDPa1-095,gantenerumab,QVELVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINASGTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGKGNTHKPYGYVRYFDVWGQGTLVTVSS,DIVLTQSPATLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFATYYCLQIYNMPITFGQGTKVEIK,DIVLTQSPATLSLSPGERATLSCRAS--QSVSS-----SYLAWYQQKPGQAPRLLIYG--------ASSRATGVPARFSGSGSG--TDFTLTISSLEPEDFATYYCLQIYN-----------------------MPITFGQGTKVEIK-,QVELVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YAMSWVRQAPGKGLEWVSAINAS---GTRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGKGNTHKP-------------YGYVRYFDVWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-096,gatipotuzumab,EVQLVESGGGLVQPGGSMRLSCVASGFPFSNYWMNWVRQAPGKGLEWVGEIRLKSNNYTTHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTRHYYFDYWGQGTLVTVSS,DIVMTQSPLSNPVTPGEPASISCRSSKSLLHSNGITYFFWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFGQGTKVEIK,DIVMTQSPLSNPVTPGEPASISCRSS--KSLLHSN-GITYFFWYLQKPGQSPQLLIYQ--------MSNLASGVPDRFSGSGSG--TDFTLRISRVEAEDVGVYYCAQNLE-----------------------LPPTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSMRLSCVASG-FPFSN-----YWMNWVRQAPGKGLEWVGEIRLKS-NNYTTHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTRHYY------------------------FDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-097,gemtuzumab,EVQLVQSGAEVKKPGSSVKVSCKASGYTITDSNIHWVRQAPGQSLEWIGYIYPYNGGTDYNQKFKNRATLTVDNPTNTAYMELSSLRSEDTAFYYCVNGNPWLAYWGQGTLVTVSS,DIQLTQSPSTLSASVGDRVTITCRASESLDNYGIRFLTWFQQKPGKAPKLLMYAASNQGSGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQTKEVPWSFGQGTKVEVK,DIQLTQSPSTLSASVGDRVTITCRAS--ESLDNY--GIRFLTWFQQKPGKAPKLLMYA--------ASNQGSGVPSRFSGSGSG--TEFTLTISSLQPDDFATYYCQQTKE-----------------------VPWSFGQGTKVEVK-,EVQLVQS-GAEVKKPGSSVKVSCKASG-YTITD-----SNIHWVRQAPGQSLEWIGYIYPY---NGGTDYNQKFKNRATLTVDNPTNTAYMELSSLRSEDTAFYYCVNGNP-----------------------WLAYWGQGTLVTVSS,IgG4,Kappa,0
GDPa1-098,gevokizumab,QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSS,DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIK,DIQMTQSTSSLSASVGDRVTITCRAS--QDIS------NYLSWYQQKPGKAVKLLIYY--------TSKLHSGVPSRFSGSGSG--TDYTLTISSLQQEDFATYFCLQGKM-----------------------LPWTFGQGTKLEIK-,QVQLQES-GPGLVKPSQTLSLTCSFSG-FSLSTS---GMGVGWIRQPSGKGLEWLAHIWW----DGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDP--------------------PWFVDWGQGTLVTVSS,IgG2,Kappa,1
GDPa1-099,gimsilumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSRHWMHWLRQVPGKGPVWVSRINGAGTSITYADSVRGRFTISRDNANNTLFLQMNSLRADDTALYFCARANSVWFRGLFDYWGQGTPVTVSS,EIVLTQSPVTLSVSPGERVTLSCRASQSVSTNLAWYQQKLGQGPRLLIYGASTRATDIPARFSGSGSETEFTLTISSLQSEDFAVYYCQQYDKWPDTFGQGTKLEIK,EIVLTQSPVTLSVSPGERVTLSCRAS--QSVS------TNLAWYQQKLGQGPRLLIYG--------ASTRATDIPARFSGSGSE--TEFTLTISSLQSEDFAVYYCQQYDK-----------------------WPDTFGQGTKLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSR-----HWMHWLRQVPGKGPVWVSRINGA---GTSITYADSVRGRFTISRDNANNTLFLQMNSLRADDTALYFCARANSVWF------------------RGLFDYWGQGTPVTVSS,IgG1,Kappa,2
GDPa1-100,girentuximab,DVKLVESGGGLVKLGGSLKLSCAASGFTFSNYYMSWVRQTPEKRLELVAAINSDGGITYYLDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALFYCARHRSGYFSMDYWGQGTSVTVSS,DIVMTQSQRFMSTTVGDRVSITCKASQNVVSAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADFFCQQYSNYPWTFGGGTKLEIK,DIVMTQSQRFMSTTVGDRVSITCKAS--QNVV------SAVAWYQQKPGQSPKLLIYS--------ASNRYTGVPDRFTGSGSG--TDFTLTISNMQSEDLADFFCQQYSN-----------------------YPWTFGGGTKLEIK-,DVKLVES-GGGLVKLGGSLKLSCAASG-FTFSN-----YYMSWVRQTPEKRLELVAAINSD---GGITYYLDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALFYCARHRSGY--------------------FSMDYWGQGTSVTVSS,IgG1,Kappa,3
GDPa1-101,glembatumumab,QVQLQESGPGLVKPSQTLSLTCTVSGGSISSFNYYWSWIRHHPGKGLEWIGYIYYSGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNWNYFDYWGQGTLVTVSS,EIVMTQSPATLSVSPGERATLSCRASQSVDNNLVWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPWTFGQGTKVEIK,EIVMTQSPATLSVSPGERATLSCRAS--QSVD------NNLVWYQQKPGQAPRLLIYG--------ASTRATGIPARFSGSGSG--TEFTLTISSLQSEDFAVYYCQQYNNW----------------------PPWTFGQGTKVEIK-,QVQLQES-GPGLVKPSQTLSLTCTVSG-GSISSF---NYYWSWIRHHPGKGLEWIGYIYY----SGSTYSNPSLKSRVTISVDTSKNQFSLTLSSVTAADTAVYYCARGYNW---------------------NYFDYWGQGTLVTVSS,IgG2,Kappa,1
GDPa1-102,golimumab,QVQLVESGGGVVQPGRSLRLSCAASGFIFSSYAMHWVRQAPGNGLEWVAFMSYDGSNKKYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGIAAGGNYYYYGMDVWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVYSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPFTFGPGTKVDIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVY------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSNW----------------------PPFTFGPGTKVDIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FIFSS-----YAMHWVRQAPGNGLEWVAFMSYD---GSNKKYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRGIAAGG-------------NYYYYGMDVWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-103,guselkumab,EVQLVQSGAEVKKPGESLKISCKGSGYSFSNYWIGWVRQMPGKGLEWMGIIDPSNSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARWYYKPFDVWGQGTLVTVSS,QSVLTQPPSVSGAPGQRVTISCTGSSSNIGSGYDVHWYQQLPGTAPKLLIYGNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCASWTDGLSLVVFGGGTKLTVL,QSVLTQP-PSVSGAPGQRVTISCTGSS-SNIGS----GYDVHWYQQLPGTAPKLLIYG--------NSKRPSGVPDRFSGSKSG--TSASLAITGLQSEDEADYYCASWTDG---------------------LSLVVFGGGTKLTVL-,EVQLVQS-GAEVKKPGESLKISCKGSG-YSFSN-----YWIGWVRQMPGKGLEWMGIIDPS---NSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARWYYK----------------------PFDVWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-104,ianalumab,QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWGWIRQSPGRGLEWLGRIYYRSKWYNSYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARYQWVPKIGVFDSWGQGTLVTVSS,DIVLTQSPATLSLSPGERATLSCRASQFILPEYLSWYQQKPGQAPRLLIYGSSSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQFYSSPLTFGQGTKVEIK,DIVLTQSPATLSLSPGERATLSCRAS--QFILP-----EYLSWYQQKPGQAPRLLIYG--------SSSRATGVPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQFYS-----------------------SPLTFGQGTKVEIK-,QVQLQQS-GPGLVKPSQTLSLTCAISG-DSVSSN---SAAWGWIRQSPGRGLEWLGRIYYR--SKWYNSYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARYQWVPK------------------IGVFDSWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-105,ibalizumab,QVQLQQSGPEVVKPGASVKMSCKASGYTFTSYVIHWVRQKPGQGLDWIGYINPYNDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYATGAWFAYWGQGTLVTVSS,DIVMTQSPDSLAVSLGERVTMNCKSSQSLLYSTNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSVQAEDVAVYYCQQYYSYRTFGGGTKLEIK,DIVMTQSPDSLAVSLGERVTMNCKSS--QSLLYSTNQKNYLAWYQQKPGQSPKLLIYW--------ASTRESGVPDRFSGSGSG--TDFTLTISSVQAEDVAVYYCQQYYS------------------------YRTFGGGTKLEIK-,QVQLQQS-GPEVVKPGASVKMSCKASG-YTFTS-----YVIHWVRQKPGQGLDWIGYINPY---NDGTDYDEKFKGKATLTSDTSTSTAYMELSSLRSEDTAVYYCAREKDNYA-----------------TGAWFAYWGQGTLVTVSS,IgG4,Kappa,4
GDPa1-106,icrucumab,QAQVVESGGGVVQSGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARDHYGSGVHHYFYYGLDVWGQGTTVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------SPLTFGGGTKVEIK-,QAQVVES-GGGVVQSGRSLRLSCAASG-FAFSS-----YGMHWVRQAPGKGLEWVAVIWYD---GSNKYYADSVRGRFTISRDNSENTLYLQMNSLRAEDTAVYYCARDHYGSGVH-------------HYFYYGLDVWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-107,imgatuzumab,QVQLVQSGAEVKKPGSSVKVSCKASGFTFTDYKIHWVRQAPGQGLEWMGYFNPNSGYSTYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSPGGYYVMDAWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGINNYLNWYQQKPGKAPKRLIYNTNNLQTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSFPTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIN------NYLNWYQQKPGKAPKRLIYN--------TNNLQTGVPSRFSGSGSG--TEFTLTISSLQPEDFATYYCLQHNS------------------------FPTFGQGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-FTFTD-----YKIHWVRQAPGQGLEWMGYFNPN---SGYSTYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARLSPGG-------------------YYVMDAWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-108,inclacumab,EVQLVESGGGLVRPGGSLRLSCAASGFTFSNYDMHWVRQATGKGLEWVSAITAAGDIYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGRYSGSGSYYNDWFDPWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WPLTFGGGTKVEIK-,EVQLVES-GGGLVRPGGSLRLSCAASG-FTFSN-----YDMHWVRQATGKGLEWVSAITA----AGDIYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGRYSGSGS--------------YYNDWFDPWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-109,inebilizumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSWMNWVRQAPGKGLEWVGRIYPGDGDTNYNVKFKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARSGFITTVRDFDYWGQGTLVTVSS,EIVLTQSPDFQSVTPKEKVTITCRASESVDTFGISFMNWFQQKPDQSPKLLIHEASNQGSGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQSKEVPFTFGGGTKVEIK,EIVLTQSPDFQSVTPKEKVTITCRAS--ESVDTF--GISFMNWFQQKPDQSPKLLIHE--------ASNQGSGVPSRFSGSGSG--TDFTLTINSLEAEDAATYYCQQSKE-----------------------VPFTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----SWMNWVRQAPGKGLEWVGRIYPG---DGDTNYNVKFKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARSGFITT------------------VRDFDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-110,infliximab,EVKLEESGGGLVQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSS,DILLTQSPAILSVSPGERVSFSCRASQFVGSSIHWYQQRTNGSPRLLIKYASESMSGIPSRFSGSGSGTDFTLSINTVESEDIADYYCQQSHSWPFTFGSGTNLEVK,DILLTQSPAILSVSPGERVSFSCRAS--QFVG------SSIHWYQQRTNGSPRLLIKY--------ASESMSGIPSRFSGSGSG--TDFTLSINTVESEDIADYYCQQSHS-----------------------WPFTFGSGTNLEVK-,EVKLEES-GGGLVQPGGSMKLSCVASG-FIFSN-----HWMNWVRQSPEKGLEWVAEIRSKS-INSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYG---------------------STYDYWGQGTTLTVSS,IgG1,Kappa,1
GDPa1-111,inotuzumab,EVQLVQSGAEVKKPGASVKVSCKASGYRFTNYWIHWVRQAPGQGLEWIGGINPGNNYATYRRKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTREGYGNYGAWFAYWGQGTLVTVSS,DVQVTQSPSSLSASVGDRVTITCRSSQSLANSYGNTFLSWYLHKPGKAPQLLIYGISNRFSGVPDRFSGSGSGTDFTLTISSLQPEDFATYYCLQGTHQPYTFGQGTKVEIK,DVQVTQSPSSLSASVGDRVTITCRSS--QSLANSY-GNTFLSWYLHKPGKAPQLLIYG--------ISNRFSGVPDRFSGSGSG--TDFTLTISSLQPEDFATYYCLQGTH-----------------------QPYTFGQGTKVEIK-,EVQLVQS-GAEVKKPGASVKVSCKASG-YRFTN-----YWIHWVRQAPGQGLEWIGGINPG---NNYATYRRKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTREGYGNY------------------GAWFAYWGQGTLVTVSS,IgG4,Kappa,0
GDPa1-112,intetumumab,QVQLVESGGGVVQPGRSRRLSCAASGFTFSRYTMHWVRQAPGKGLEWVAVISFDGSNKYYVDSVKGRFTISRDNSENTLYLQVNILRAEDTAVYYCAREARGSYAFDIWGQGTMVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPFTFGPGTKVDIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSNW----------------------PPFTFGPGTKVDIK-,QVQLVES-GGGVVQPGRSRRLSCAASG-FTFSR-----YTMHWVRQAPGKGLEWVAVISFD---GSNKYYVDSVKGRFTISRDNSENTLYLQVNILRAEDTAVYYCAREARGS--------------------YAFDIWGQGTMVTVSS,IgG1,Kappa,2
GDPa1-113,ipilimumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVGS-----SYLAWYQQKPGQAPRLLIYG--------AFSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------SPWTFGQGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YTMHWVRQAPGKGLEWVTFISYD---GNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWL---------------------GPFDYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-114,isatuximab,QVQLVQSGAEVAKPGTSVKLSCKASGYTFTDYWMQWVKQRPGQGLEWIGTIYPGDGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYGSNSLDYWGQGTSVTVSS,DIVMTQSHLSMSTSLGDPVSITCKASQDVSTVVAWYQQKPGQSPRRLIYSASYRYIGVPDRFTGSGAGTDFTFTISSVQAEDLAVYYCQQHYSPPYTFGGGTKLEIK,DIVMTQSHLSMSTSLGDPVSITCKAS--QDVS------TVVAWYQQKPGQSPRRLIYS--------ASYRYIGVPDRFTGSGAG--TDFTFTISSVQAEDLAVYYCQQHYS-----------------------PPYTFGGGTKLEIK-,QVQLVQS-GAEVAKPGTSVKLSCKASG-YTFTD-----YWMQWVKQRPGQGLEWIGTIYPG---DGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYG-------------------SNSLDYWGQGTSVTVSS,IgG1,Kappa,2
GDPa1-115,iscalimab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSS,DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIR,DIVMTQSPLSLTVTPGEPASISCRSS--QSLLYSN-GYNYLDWYLQKPGQSPQVLISL--------GSNRASGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCMQARQ-----------------------TPFTFGPGTKVDIR-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAVISYE---ESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIA-------------------APGPDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-116,itolizumab,EVQLVESGGGLVKPGGSLKLSCAASGFKFSRYAMSWVRQAPGKRLEWVATISSGGSYIYYPDSVKGRFTISRDNVKNTLYLQMSSLRSEDTAMYYCARRDYDLDYFDSWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASRDIRSYLTWYQQKPGKAPKTLIYYATSLADGVPSRFSGSGSGQDYSLTISSLESDDTATYYCLQHGESPFTLGSGTKLEIK,DIQMTQSPSSLSASVGDRVTITCKAS--RDIR------SYLTWYQQKPGKAPKTLIYY--------ATSLADGVPSRFSGSGSG--QDYSLTISSLESDDTATYYCLQHGE-----------------------SPFTLGSGTKLEIK-,EVQLVES-GGGLVKPGGSLKLSCAASG-FKFSR-----YAMSWVRQAPGKRLEWVATISSG---GSYIYYPDSVKGRFTISRDNVKNTLYLQMSSLRSEDTAMYYCARRDYDL--------------------DYFDSWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-117,ixekizumab,QVQLVQSGAEVKKPGSSVKVSCKASGYSFTDYHIHWVRQAPGQGLEWMGVINPMYGTTDYNQRFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDYFTGTGVYWGQGTLVTVSS,DIVMTQTPLSLSVTPGQPASISCRSSRSLVHSRGNTYLHWYLQKPGQSPQLLIYKVSNRFIGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHLPFTFGQGTKLEIK,DIVMTQTPLSLSVTPGQPASISCRSS--RSLVHSR-GNTYLHWYLQKPGQSPQLLIYK--------VSNRFIGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCSQSTH-----------------------LPFTFGQGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YSFTD-----YHIHWVRQAPGQGLEWMGVINPM---YGTTDYNQRFKGRVTITADESTSTAYMELSSLRSEDTAVYYCARYDYFT--------------------GTGVYWGQGTLVTVSS,IgG4,Kappa,4
GDPa1-118,ladiratuzumab,QVQLVQSGAEVKKPGASVKVSCKASGLTIEDYYMHWVRQAPGQGLEWMGWIDPENGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHYGTWFAYWGQGTLVTVSS,DVVMTQSPLSLPVTLGQPASISCRSSQSLLHSSGNTYLEWYQQRPGQSPRPLIYKISTRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPYTFGGGTKVEIK,DVVMTQSPLSLPVTLGQPASISCRSS--QSLLHSS-GNTYLEWYQQRPGQSPRPLIYK--------ISTRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSH-----------------------VPYTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-LTIED-----YYMHWVRQAPGQGLEWMGWIDPE---NGDTEYGPKFQGRVTMTRDTSINTAYMELSRLRSDDTAVYYCAVHNAHY-------------------GTWFAYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-119,lampalizumab,EVQLVQSGPELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGGVNNWGQGTLVTVSS,DIQVTQSPSSLSASVGDRVTITCITSTDIDDDMNWYQQKPGKVPKLLISGGNTLRPGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCLQSDSLPYTFGQGTKVEIK,DIQVTQSPSSLSASVGDRVTITCITS--TDID------DDMNWYQQKPGKVPKLLISG--------GNTLRPGVPSRFSGSGSG--TDFTLTISSLQPEDVATYYCLQSDS-----------------------LPYTFGQGTKVEIK-,EVQLVQS-GPELKKPGASVKVSCKASG-YTFTN-----YGMNWVRQAPGQGLEWMGWINTY---TGETTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCEREGG------------------------VNNWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-120,lanadelumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSS,DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNTYWTFGQGTKVEIK,DIQMTQSPSTLSASVGDRVTITCRAS--QSIS------SWLAWYQQKPGKAPKLLIYK--------ASTLESGVPSRFSGSGSG--TEFTLTISSLQPDDFATYYCQQYNT------------------------YWTFGQGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSH-----YIMMWVRQAPGKGLEWVSGIYSS---GGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVP-----------------RRDEFDIWGQGTMVTVSS,IgG1,Kappa,0
GDPa1-121,landogrozumab,EVQLVESGGGLVQPGGSLRLSCAASGLTFSRYPMSWVRQAPGKGLVWVSAITSSGGSTYYSDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARLPDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASSSVSSSYLHWYQQKPGQAPRLLIYSTSNLVAGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHHSGYHFTFGGGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--SSVSS-----SYLHWYQQKPGQAPRLLIYS--------TSNLVAGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQHHSG-----------------------YHFTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-LTFSR-----YPMSWVRQAPGKGLVWVSAITSS---GGSTYYSDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARLP--------------------------DYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-122,lebrikizumab,QVTLRESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSS,DIVMTQSPDSLSVSLGERATINCRASKSVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPRTFGGGTKVEIK,DIVMTQSPDSLSVSLGERATINCRAS--KSVDSY--GNSFMHWYQQKPGQPPKLLIYL--------ASNLESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQQNNE-----------------------DPRTFGGGTKVEIK-,QVTLRES-GPALVKPTQTLTLTCTVSG-FSLSA-----YSVNWIRQPPGKALEWLAMIWG----DGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYP--------------------YAMDNWGQGSLVTVSS,IgG4,Kappa,2
GDPa1-123,lenzilumab,QVQLVQSGAEVKKPGASVKVSCKASGYSFTNYYIHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCVRRQRFPYYFDYWGQGTLVTVSS,EIVLTQSPATLSVSPGERATLSCRASQSVGTNVAWYQQKPGQAPRVLIYSTSSRATGITDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFNKSPLTFGGGTKVEIK,EIVLTQSPATLSVSPGERATLSCRAS--QSVG------TNVAWYQQKPGQAPRVLIYS--------TSSRATGITDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQFNK-----------------------SPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YSFTN-----YYIHWVRQAPGQRLEWMGWINAG---NGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCVRRQRFP--------------------YYFDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-124,lexatumumab,EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEWVSGINWNGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDLWGKGTTVTVSS,SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHVVFGGGTKLTVL,SSELTQD-PAVSVALGQTVRITCQGD---SLRS-----YYASWYQQKPGQAPVLVIYG--------KNNRPSGIPDRFSGSSSG--NTASLTITGAQAEDEADYYCNSRDSS---------------------GNHVVFGGGTKLTVL-,EVQLVQS-GGGVERPGGSLRLSCAASG-FTFDD-----YGMSWVRQAPGKGLEWVSGINWN---GGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGR------------------GWYFDLWGKGTTVTVSS,IgG1,Lambda,4
GDPa1-125,ligelizumab,QVQLVQSGAEVMKPGSSVKVSCKASGYTFSWYWLEWVRQAPGHGLEWMGEIDPGTFTTNYNEKFKARVTFTADTSTSTAYMELSSLRSEDTAVYYCARFSHFSGSNYDYFDYWGQGTLVTVSS,EIVMTQSPATLSVSPGERATLSCRASQSIGTNIHWYQQKPGQAPRLLIYYASESISGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQSWSWPTTFGGGTKVEIK,EIVMTQSPATLSVSPGERATLSCRAS--QSIG------TNIHWYQQKPGQAPRLLIYY--------ASESISGIPARFSGSGSG--TEFTLTISSLQSEDFAVYYCQQSWS-----------------------WPTTFGGGTKVEIK-,QVQLVQS-GAEVMKPGSSVKVSCKASG-YTFSW-----YWLEWVRQAPGHGLEWMGEIDPG---TFTTNYNEKFKARVTFTADTSTSTAYMELSSLRSEDTAVYYCARFSHFSGS----------------NYDYFDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-126,lintuzumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDYNMHWVRQAPGQGLEWIGYIYPYNGGTGYNQKFKSKATITADESTNTAYMELSSLRSEDTAVYYCARGRPAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASESVDNYGISFMNWFQQKPGKAPKLLIYAASNQGSGVPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQSKEVPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--ESVDNY--GISFMNWFQQKPGKAPKLLIYA--------ASNQGSGVPSRFSGSGSG--TDFTLTISSLQPDDFATYYCQQSKE-----------------------VPWTFGQGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFTD-----YNMHWVRQAPGQGLEWIGYIYPY---NGGTGYNQKFKSKATITADESTNTAYMELSSLRSEDTAVYYCARGRP-----------------------AMDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-127,lirilumab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSFYAISWVRQAPGQGLEWMGGFIPIFGAANYAQKFQGRVTITADESTSTAYMELSSLRSDDTAVYYCARIPSGSYYYDYDMDVWGQGTTVTVSS,EIVLTQSPVTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWMYTFGQGTKLEIK,EIVLTQSPVTLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WMYTFGQGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSF-----YAISWVRQAPGQGLEWMGGFIPI---FGAANYAQKFQGRVTITADESTSTAYMELSSLRSDDTAVYYCARIPSGSYY----------------YDYDMDVWGQGTTVTVSS,IgG4,Kappa,3
GDPa1-128,loncastuximab,QVQLVQPGAEVVKPGASVKLSCKTSGYTFTSNWMHWVKQAPGQGLEWIGEIDPSDSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPYYYAMDYWGQGTSVTVSS,EIVLTQSPAIMSASPGERVTMTCSASSGVNYMHWYQQKPGTSPRRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEPEDAATYYCHQRGSYTFGGGTKLEIK,EIVLTQSPAIMSASPGERVTMTCSAS--SGVN-------YMHWYQQKPGTSPRRWIYD--------TSKLASGVPARFSGSGSG--TSYSLTISSMEPEDAATYYCHQRG-------------------------SYTFGGGTKLEIK-,QVQLVQP-GAEVVKPGASVKLSCKTSG-YTFTS-----NWMHWVKQAPGQGLEWIGEIDPS---DSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPY-------------------YYAMDYWGQGTSVTVSS,IgG1,Kappa,2
GDPa1-129,lorvotuzumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAYISSGSFTIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARMRKGYAMDYWGQGTLVTVSS,DVVMTQSPLSLPVTLGQPASISCRSSQIIIHSDGNTYLEWFQQRPGQSPRRLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPHTFGQGTKVEIK,DVVMTQSPLSLPVTLGQPASISCRSS--QIIIHSD-GNTYLEWFQQRPGQSPRRLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSH-----------------------VPHTFGQGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----FGMHWVRQAPGKGLEWVAYISSG---SFTIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARMRKG---------------------YAMDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-130,lucatumumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYEESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIAAPGPDYWGQGTLVTVSS,DIVMTQSPLSLTVTPGEPASISCRSSQSLLYSNGYNYLDWYLQKPGQSPQVLISLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQARQTPFTFGPGTKVDIR,DIVMTQSPLSLTVTPGEPASISCRSS--QSLLYSN-GYNYLDWYLQKPGQSPQVLISL--------GSNRASGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCMQARQ-----------------------TPFTFGPGTKVDIR-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAVISYE---ESNRYHADSVKGRFTISRDNSKITLYLQMNSLRTEDTAVYYCARDGGIA-------------------APGPDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-131,lumiliximab,EVQLVESGGGLAKPGGSLRLSCAASGFRFTFNNYYMDWVRQAPGQGLEWVSRISSSGDPTWYADSVKGRFTISRENANNTLFLQMNSLRAEDTAVYYCASLTTGSDSWGQGVLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDIRYYLNWYQQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTEFTLTVSSLQPEDFATYYCLQVYSTPRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDIR------YYLNWYQQKPGKAPKLLIYV--------ASSLQSGVPSRFSGSGSG--TEFTLTVSSLQPEDFATYYCLQVYS-----------------------TPRTFGQGTKVEIK-,EVQLVES-GGGLAKPGGSLRLSCAASG-FRFTFN---NYYMDWVRQAPGQGLEWVSRISSS---GDPTWYADSVKGRFTISRENANNTLFLQMNSLRAEDTAVYYCASLTT-----------------------GSDSWGQGVLVTVSS,IgG1,Kappa,0
GDPa1-132,lumretuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFRSSYISWVRQAPGQGLEWMGWIYAGTGSPSYNQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARHRDYYSNSLTYWGQGTLVTVSS,DIVMTQSPDSLAVSLGERATINCKSSQSVLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQSDYSYPYTFGQGTKLEIK,DIVMTQSPDSLAVSLGERATINCKSS--QSVLNSGNQKNYLTWYQQKPGQPPKLLIYW--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQSDYS-----------------------YPYTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFRS-----SYISWVRQAPGQGLEWMGWIYAG---TGSPSYNQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARHRDYY-------------------SNSLTYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-133,margetuximab,QVQLQQSGPELVKPGASLKLSCTASGFNIKDTYIHWVKQRPEQGLEWIGRIYPTNGYTRYDPKFQDKATITADTSSNTAYLQVSRLTSEDTAVYYCSRWGGDGFYAMDYWGQGASVTVSS,DIVMTQSHKFMSTSVGDRVSITCKASQDVNTAVAWYQQKPGHSPKLLIYSASFRYTGVPDRFTGSRSGTDFTFTISSVQAEDLAVYYCQQHYTTPPTFGGGTKVEIK,DIVMTQSHKFMSTSVGDRVSITCKAS--QDVN------TAVAWYQQKPGHSPKLLIYS--------ASFRYTGVPDRFTGSRSG--TDFTFTISSVQAEDLAVYYCQQHYT-----------------------TPPTFGGGTKVEIK-,QVQLQQS-GPELVKPGASLKLSCTASG-FNIKD-----TYIHWVKQRPEQGLEWIGRIYPT---NGYTRYDPKFQDKATITADTSSNTAYLQVSRLTSEDTAVYYCSRWGGDG-------------------FYAMDYWGQGASVTVSS,IgG1,Kappa,2
GDPa1-134,matuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSHWMHWVRQAPGQGLEWIGEFNPSNGRTNYNEKFKSKATMTVDTSTNTAYMELSSLRSEDTAVYYCASRDYDYDGRYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCSASSSVTYMYWYQQKPGKAPKLLIYDTSNLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSHIFTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCSAS--SSVT-------YMYWYQQKPGKAPKLLIYD--------TSNLASGVPSRFSGSGSG--TDYTFTISSLQPEDIATYYCQQWSS-----------------------HIFTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----HWMHWVRQAPGQGLEWIGEFNPS---NGRTNYNEKFKSKATMTVDTSTNTAYMELSSLRSEDTAVYYCASRDYDYD------------------GRYFDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-135,mavrilimumab,QVQLVQSGAEVKKPGASVKVSCKVSGYTLTELSIHWVRQAPGKGLEWMGGFDPEENEIVYAQRFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAIVGSFSPLTLGLWGQGTMVTVSS,QSVLTQPPSVSGAPGQRVTISCTGSGSNIGAPYDVSWYQQLPGTAPKLLIYHNNKRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCATVEAGLSGSVFGGGTKLTVL,QSVLTQP-PSVSGAPGQRVTISCTGSG-SNIGA----PYDVSWYQQLPGTAPKLLIYH--------NNKRPSGVPDRFSGSKSG--TSASLAITGLQAEDEADYYCATVEAG---------------------LSGSVFGGGTKLTVL-,QVQLVQS-GAEVKKPGASVKVSCKVSG-YTLTE-----LSIHWVRQAPGKGLEWMGGFDPE---ENEIVYAQRFQGRVTMTEDTSTDTAYMELSSLRSEDTAVYYCAIVGSFS-------------------PLTLGLWGQGTMVTVSS,IgG4,Lambda,2
GDPa1-136,mepolizumab,QVTLRESGPALVKPTQTLTLTCTVSGFSLTSYSVHWVRQPPGKGLEWLGVIWASGGTDYNSALMSRLSISKDTSRNQVVLTMTNMDPVDTATYYCARDPPSSLLRLDYWGRGTPVTVSS,DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLAWYQQKPGQPPKLLIYGASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNVHSFPFTFGGGTKLEIK,DIVMTQSPDSLAVSLGERATINCKSS--QSLLNSGNQKNYLAWYQQKPGQPPKLLIYG--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQNVHS-----------------------FPFTFGGGTKLEIK-,QVTLRES-GPALVKPTQTLTLTCTVSG-FSLTS-----YSVHWVRQPPGKGLEWLGVIWA----SGGTDYNSALMSRLSISKDTSRNQVVLTMTNMDPVDTATYYCARDPPSS-------------------LLRLDYWGRGTPVTVSS,IgG1,Kappa,3
GDPa1-137,milatuzumab,QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGVNWIKQAPGQGLQWMGWINPNTGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKNEAWFAYWGQGTLVTVSS,DIQLTQSPLSLPVTLGQPASISCRSSQSLVHRNGNTYLHWFQQRPGQSPRLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSSHVPPTFGAGTRLEIK,DIQLTQSPLSLPVTLGQPASISCRSS--QSLVHRN-GNTYLHWFQQRPGQSPRLLIYT--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYFCSQSSH-----------------------VPPTFGAGTRLEIK-,QVQLQQS-GSELKKPGASVKVSCKASG-YTFTN-----YGVNWIKQAPGQGLQWMGWINPN---TGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKN-------------------EAWFAYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-138,mirikizumab,QVQLVQSGAEVKKPGSSVKVSCKASGYKFTRYVMHWVRQAPGQGLEWMGYINPYNDGTNYNEKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNWDTGLWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCKASDHILKFLTWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQMYWSTPFTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--DHIL------KFLTWYQQKPGKAPKLLIYG--------ATSLETGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQMYWS-----------------------TPFTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YKFTR-----YVMHWVRQAPGQGLEWMGYINPY---NDGTNYNEKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNWD------------------------TGLWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-139,mirvetuximab,QVQLVQSGAEVVKPGASVKISCKASGYTFTGYFMNWVKQSPGQSLEWIGRIHPYDGDTFYNQKFQGKATLTVDKSSNTAHMELLSLTSEDFAVYYCTRYDGSRAMDYWGQGTTVTVSS,DIVLTQSPLSLAVSLGQPAIISCKASQSVSFAGTSLMHWYHQKPGQQPRLLIYRASNLEAGVPDRFSGSGSKTDFTLTISPVEAEDAATYYCQQSREYPYTFGGGTKLEIK,DIVLTQSPLSLAVSLGQPAIISCKAS--QSVSFA--GTSLMHWYHQKPGQQPRLLIYR--------ASNLEAGVPDRFSGSGSK--TDFTLTISPVEAEDAATYYCQQSRE-----------------------YPYTFGGGTKLEIK-,QVQLVQS-GAEVVKPGASVKISCKASG-YTFTG-----YFMNWVKQSPGQSLEWIGRIHPY---DGDTFYNQKFQGKATLTVDKSSNTAHMELLSLTSEDFAVYYCTRYDGS---------------------RAMDYWGQGTTVTVSS,IgG1,Kappa,4
GDPa1-140,mitazalimab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYGMHWVRQAPGKGLEWLSYISGGSSYIFYADSVRGRFTISRDNSENALYLQMNSLRAEDTAVYYCARILRGGSGMDLWGQGTLVTVSS,QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYNVYWYQQLPGTAPKLLIYGNINRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDKSISGLVFGGGTKLTVL,QSVLTQP-PSASGTPGQRVTISCTGSS-SNIGA----GYNVYWYQQLPGTAPKLLIYG--------NINRPSGVPDRFSGSKSG--TSASLAISGLRSEDEADYYCAAWDKS---------------------ISGLVFGGGTKLTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFST-----YGMHWVRQAPGKGLEWLSYISGG---SSYIFYADSVRGRFTISRDNSENALYLQMNSLRAEDTAVYYCARILRGG--------------------SGMDLWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-141,mogamulizumab,EVQLVESGGDLVQPGRSLRLSCAASGFIFSNYGMSWVRQAPGKGLEWVATISSASTYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRVEDTALYYCGRHSDGNFAFGYWGQGTLVTVSS,DVLMTQSPLSLPVTPGEPASISCRSSRNIVHINGDTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSLLPWTFGQGTKVEIK,DVLMTQSPLSLPVTPGEPASISCRSS--RNIVHIN-GDTYLEWYLQKPGQSPQLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSL-----------------------LPWTFGQGTKVEIK-,EVQLVES-GGDLVQPGRSLRLSCAASG-FIFSN-----YGMSWVRQAPGKGLEWVATISSA---STYSYYPDSVKGRFTISRDNAKNSLYLQMNSLRVEDTALYYCGRHSDGN--------------------FAFGYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-142,monalizumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMNWVRQAPGQGLEWMGRIDPYDSETHYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGYDFDVGTLYWFFDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGTPRTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--ENIY------SYLAWYQQKPGKAPKLLIYN--------AKTLAEGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQHHYG-----------------------TPRTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YWMNWVRQAPGQGLEWMGRIDPY---DSETHYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGYDFDVG--------------TLYWFFDVWGQGTTVTVSS,IgG4,Kappa,0
GDPa1-143,mosunetuzumab,EVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYIHWVRQAPGQGLEWIGWIYPGDGNTKYNEKFKGRATLTADTSTSTAYLELSSLRSEDTAVYYCARDSYSNYYFDYWGQGTLVTVSS,DIVMTQSPDSLAVSLGERATINCKSSQSLLNSRTRKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCTQSFILRTFGQGTKVEIK,DIVMTQSPDSLAVSLGERATINCKSS--QSLLNSRTRKNYLAWYQQKPGQPPKLLIYW--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCTQSFI------------------------LRTFGQGTKVEIK-,EVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----YYIHWVRQAPGQGLEWIGWIYPG---DGNTKYNEKFKGRATLTADTSTSTAYLELSSLRSEDTAVYYCARDSYSN--------------------YYFDYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-144,motavizumab,QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSS,DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIK,DIQMTQSPSTLSASVGDRVTITCSAS--SRVG-------YMHWYQQKPGKAPKLLIYD--------TSKLASGVPSRFSGSGSG--TEFTLTISSLQPDDFATYYCFQGSG-----------------------YPFTFGGGTKVEIK-,QVTLRES-GPALVKPTQTLTLTCTFSG-FSLSTA---GMSVGWIRQPPGKALEWLADIWW----DDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFN--------------------FYFDVWGQGTTVTVSS,IgG1,Kappa,3
GDPa1-145,muromonab,QVQLQQSGAELARPGASVKMSCKASGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLTVSS,QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMNWYQQKSGTSPKRWIYDTSKLASGVPAHFRGSGSGTSYSLTISGMEAEDAATYYCQQWSSNPFTFGSGTKLEIK,QIVLTQSPAIMSASPGEKVTMTCSAS--SSVS-------YMNWYQQKSGTSPKRWIYD--------TSKLASGVPAHFRGSGSG--TSYSLTISGMEAEDAATYYCQQWSS-----------------------NPFTFGSGTKLEIK-,QVQLQQS-GAELARPGASVKMSCKASG-YTFTR-----YTMHWVKQRPGQGLEWIGYINPS---RGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDH--------------------YCLDYWGQGTTLTVSS,IgG2,Kappa,4
GDPa1-146,natalizumab,QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTYIHWVRQAPGQRLEWMGRIDPANGYTKYDPKFQGRVTITADTSASTAYMELSSLRSEDTAVYYCAREGYYGNYGVYAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKTSQDINKYMAWYQQTPGKAPRLLIHYTSALQPGIPSRFSGSGSGRDYTFTISSLQPEDIATYYCLQYDNLWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKTS--QDIN------KYMAWYQQTPGKAPRLLIHY--------TSALQPGIPSRFSGSGSG--RDYTFTISSLQPEDIATYYCLQYDN------------------------LWTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-FNIKD-----TYIHWVRQAPGQRLEWMGRIDPA---NGYTKYDPKFQGRVTITADTSASTAYMELSSLRSEDTAVYYCAREGYYGNY----------------GVYAMDYWGQGTLVTVSS,IgG4,Kappa,0
GDPa1-147,necitumumab,QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYYWSWIRQPPGKGLEWIGYIYYSGSTDYNPSLKSRVTMSVDTSKNQFSLKVNSVTAADTAVYYCARVSIFGVGTFDYWGQGTLVTVSS,EIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYGSTPLTFGGGTKAEIK,EIVMTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCHQYGS-----------------------TPLTFGGGTKAEIK-,QVQLQES-GPGLVKPSQTLSLTCTVSG-GSISSG---DYYWSWIRQPPGKGLEWIGYIYY----SGSTDYNPSLKSRVTMSVDTSKNQFSLKVNSVTAADTAVYYCARVSIFG-------------------VGTFDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-148,nesvacumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYDIHWVRQATGKGLEWVSAIGPAGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGLITFGGLIAPFDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYDNSQTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----TYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQHYDN------------------------SQTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YDIHWVRQATGKGLEWVSAIGP----AGDTYYPGSVKGRFTISRENAKNSLYLQMNSLRAGDTAVYYCARGLITFGG----------------LIAPFDYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-149,nimotuzumab,QVQLQQSGAEVKKPGSSVKVSCKASGYTFTNYYIYWVRQAPGQGLEWIGGINPTSGGSNFNEKFKTRVTITADESSTTAYMELSSLRSEDTAFYFCTRQGLWFDSDGRGFDFWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRSSQNIVHSNGNTYLDWYQQTPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCFQYSHVPWTFGQGTKLQIT,DIQMTQSPSSLSASVGDRVTITCRSS--QNIVHSN-GNTYLDWYQQTPGKAPKLLIYK--------VSNRFSGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCFQYSH-----------------------VPWTFGQGTKLQIT-,QVQLQQS-GAEVKKPGSSVKVSCKASG-YTFTN-----YYIYWVRQAPGQGLEWIGGINPT---SGGSNFNEKFKTRVTITADESSTTAYMELSSLRSEDTAFYFCTRQGLWFDS----------------DGRGFDFWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-150,nivolumab,QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQSSN-----------------------WPRTFGQGTKVEIK-,QVQLVES-GGGVVQPGRSLRLDCKASG-ITFSN-----SGMHWVRQAPGKGLEWVAVIWYD---GSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATND--------------------------DYWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-151,obexelimab,EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVSS,DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLNSGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIK,DIVMTQSPATLSLSPGERATLSCRSS--KSLQNVN-GNTYLYWFQQKPGQSPQLLIYR--------MSNLNSGVPDRFSGSGSG--TEFTLTISSLEPEDFAVYYCMQHLE-----------------------YPITFGAGTKLEIK-,EVQLVES-GGGLVKPGGSLKLSCAASG-YTFTS-----YVMHWVRQAPGKGLEWIGYINPY---NDGTKYNEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYG------------------TRVFDYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-152,obiltoxaximab,QVQLQQSGPELKKPGASVKVSCKDSGYAFSSSWMNWVRQAPGQGLEWIGRIYPGDGDTNYNGKFQGRVTITADKSSSTAYMELSSLRSEDTAVYFCARSGLLRYAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAVKLLIYYTSRLLPGVPSRFSGSGSGTDYSLTISSQEQEDIGTYFCQQGNTLPWTFGQGTKVEIR,DIQMTQSPSSLSASVGDRVTITCRAS--QDIR------NYLNWYQQKPGKAVKLLIYY--------TSRLLPGVPSRFSGSGSG--TDYSLTISSQEQEDIGTYFCQQGNT-----------------------LPWTFGQGTKVEIR-,QVQLQQS-GPELKKPGASVKVSCKDSG-YAFSS-----SWMNWVRQAPGQGLEWIGRIYPG---DGDTNYNGKFQGRVTITADKSSSTAYMELSSLRSEDTAVYFCARSGLLR--------------------YAMDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-153,obinutuzumab,QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSS,DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIK,DIVMTQTPLSLPVTPGEPASISCRSS--KSLLHSN-GITYLYWYLQKPGQSPQLLIYQ--------MSNLVSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCAQNLE-----------------------LPYTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YAFSY-----SWINWVRQAPGQGLEWMGRIFPG---DGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDG--------------------YWLVYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-154,ocrelizumab,EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYNMHWVRQAPGKGLEWVGAIYPGNGDTSYNQKFKGRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARVVYYSNSYWYFDVWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASSSVSYMHWYQQKPGKAPKPLIYAPSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSFNPPTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--SSVS-------YMHWYQQKPGKAPKPLIYA--------PSNLASGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQWSF-----------------------NPPTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YTFTS-----YNMHWVRQAPGKGLEWVGAIYPG---NGDTSYNQKFKGRFTISVDKSKNTLYLQMNSLRAEDTAVYYCARVVYYSN-----------------SYWYFDVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-155,ofatumumab,EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WPITFGQGTRLEIK-,EVQLVES-GGGLVQPGRSLRLSCAASG-FTFND-----YAMHWVRQAPGKGLEWVSTISWN---SGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGN-----------------YYYGMDVWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-156,olaratumab,QLQLQESGPGLVKPSETLSLTCTVSGGSINSSSYYWGWLRQSPGKGLEWIGSFFYTGSTYYNPSLRSRLTISVDTSKNQFSLMLSSVTAADTAVYYCARQSTYYYGSGNYYGWFDRWDQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPAFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WPPAFGQGTKVEIK-,QLQLQES-GPGLVKPSETLSLTCTVSG-GSINSS---SYYWGWLRQSPGKGLEWIGSFFY----TGSTYYNPSLRSRLTISVDTSKNQFSLMLSSVTAADTAVYYCARQSTYYYGS-------------GNYYGWFDRWDQGTLVTVSS,IgG1,Kappa,3
GDPa1-157,oleclumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAYSWVRQAPGKGLEWVSAISGSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLGYGRVDEWGRGTLVTVSS,QSVLTQPPSASGTPGQRVTISCSGSLSNIGRNPVNWYQQLPGTAPKLLIYLDNLRLSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSHPGWTFGGGTKLTVL,QSVLTQP-PSASGTPGQRVTISCSGSL-SNIGR-----NPVNWYQQLPGTAPKLLIYL--------DNLRLSGVPDRFSGSKSG--TSASLAISGLQSEDEADYYCATWDDS---------------------HPGWTFGGGTKLTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----YAYSWVRQAPGKGLEWVSAISGS---GGRTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLGYG----------------------RVDEWGRGTLVTVSS,IgG1,Lambda,4
GDPa1-158,olokizumab,EVQLVESGGGLVQPGGSLRLSCAASGFNFNDYFMNWVRQAPGKGLEWVAQMRNKNYQYGTYYAESLEGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARESYYGFTSYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCQASQDIGISLSWYQQKPGKAPKLLIYNANNLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCLQHNSAPYTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCQAS--QDIG------ISLSWYQQKPGKAPKLLIYN--------ANNLADGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCLQHNS-----------------------APYTFGQGTKLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FNFND-----YFMNWVRQAPGKGLEWVAQMRNKN-YQYGTYYAESLEGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARESYY---------------------GFTSYWGQGTLVTVSS,IgG4,Kappa,1
GDPa1-159,omalizumab,EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYNPSLKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSS,DIQLTQSPSSLSASVGDRVTITCRASQSVDYDGDSYMNWYQQKPGKAPKLLIYAASYLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSHEDPYTFGQGTKVEIK,DIQLTQSPSSLSASVGDRVTITCRAS--QSVDYD--GDSYMNWYQQKPGKAPKLLIYA--------ASYLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSHE-----------------------DPYTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAVSG-YSITS----GYSWNWIRQAPGKGLEWVASITY----DGSTNYNPSLKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFG------------------HWHFAVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-160,omburtamab,QVQLQQSGAELVKPGASVKLSCKASGYTFTNYDINWVRQRPEQGLEWIGWIFPGDGSTQYNEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTATWFAYWGQGTLVTVSA,DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFGAGTKLELK,DIVMTQSPATLSVTPGDRVSLSCRAS--QSIS------DYLHWYQQKSHESPRLLIKY--------ASQSISGIPSRFSGSGSG--SDFTLSINSVEPEDVGVYYCQNGHS-----------------------FPLTFGAGTKLELK-,QVQLQQS-GAELVKPGASVKLSCKASG-YTFTN-----YDINWVRQRPEQGLEWIGWIFPG---DGSTQYNEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTA---------------------TWFAYWGQGTLVTVSA,IgG1,Kappa,2
GDPa1-161,onartuzumab,EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYWLHWVRQAPGKGLEWVGMIDPSNSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYVTPLDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKSSQSLLYTSSQKNYLAWYQQKPGKAPKLLIYWASTRESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYAYPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKSS--QSLLYTSSQKNYLAWYQQKPGKAPKLLIYW--------ASTRESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYYA-----------------------YPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YTFTS-----YWLHWVRQAPGKGLEWVGMIDPS---NSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYV--------------------TPLDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-162,opicinumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSAYEMKWVRQAPGKGLEWVSVIGPSGGFTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATEGDNDAFDIWGQGTTVTVSS,DIQMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPMYTFGQGTKLEIK,DIQMTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSNW----------------------PMYTFGQGTKLEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSA-----YEMKWVRQAPGKGLEWVSVIGPS---GGFTFYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATEGDN---------------------DAFDIWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-163,orticumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSNAWMSWVRQAPGKGLEWVSSISVGGHRTYYADSVKGRSTISRDNSKNTLYLQMNSLRAEDTAVYYCARIRVGPSGGAFDYWGQGTLVTVSS,QSVLTQPPSASGTPGQRVTISCSGSNTNIGKNYVSWYQQLPGTAPKLLIYANSNRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCASWDASLNGWVFGGGTKLTVL,QSVLTQP-PSASGTPGQRVTISCSGSN-TNIGK-----NYVSWYQQLPGTAPKLLIYA--------NSNRPSGVPDRFSGSKSG--TSASLAISGLRSEDEADYYCASWDAS---------------------LNGWVFGGGTKLTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSN-----AWMSWVRQAPGKGLEWVSSISVG---GHRTYYADSVKGRSTISRDNSKNTLYLQMNSLRAEDTAVYYCARIRVGPS------------------GGAFDYWGQGTLVTVSS,IgG2,Lambda,3
GDPa1-164,osocimab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSQYGMDWVRQAPGKGLEWVSGIGPSGGSTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGGPYYYYGMDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQADSFPVTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCQAS--QDIS------NYLNWYQQKPGKAPKLLIYD--------ASNLETGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCQQADS-----------------------FPVTFGGGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSQ-----YGMDWVRQAPGKGLEWVSGIGPS---GGSTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGGPYY-------------------YYGMDVWGQGTTVTVSS,IgG4,Kappa,1
GDPa1-165,otelixizumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFPMAWVRQAPGKGLEWVSTISTSGGRTYYRDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKFRQYSGGFDYWGQGTLVTVSS,DIQLTQPNSVSTSLGSTVKLSCTLSSGNIENNYVHWYQLYEGRSPTTMIYDDDKRPDGVPDRFSGSIDRSSNSAFLTIHNVAIEDEAIYFCHSYVSSFNVFGGGTKLTVL,DIQLTQP-NSVSTSLGSTVKLSCTLSS-GNIEN-----NYVHWYQLYEGRSPTTMIYD--------DDKRPDGVPDRFSGSIDRSSNSAFLTIHNVAIEDEAIYFCHSYVS-----------------------SFNVFGGGTKLTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----FPMAWVRQAPGKGLEWVSTISTS---GGRTYYRDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKFRQYS--------------------GGFDYWGQGTLVTVSS,IgG1,Lambda,1
GDPa1-166,otlertuzumab,EVQLVQSGAEVKKPGESLKISCKGSGYSFTGYNMNWVRQMPGKGLEWMGNIDPYYGGTTYNRKFKGQVTISADKSISTAYLQWSSLKASDTAMYYCARSVGPFDSWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASENVYSYLAWYQQKPGQAPRLLIYFAKTLAEGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHHSDNPWTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--ENVY------SYLAWYQQKPGQAPRLLIYF--------AKTLAEGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQHHSD-----------------------NPWTFGQGTKVEIK-,EVQLVQS-GAEVKKPGESLKISCKGSG-YSFTG-----YNMNWVRQMPGKGLEWMGNIDPY---YGGTTYNRKFKGQVTISADKSISTAYLQWSSLKASDTAMYYCARSVG-----------------------PFDSWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-167,ozanezumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWIGNINPSNGGTNYNEKFKSKATMTRDTSTSTAYMELSSLRSEDTAVYYCELMQGYWGQGTLVTVSS,DIVMTQSPLSNPVTLGQPVSISCRSSKSLLYKDGKTYLNWFLQRPGQSPQLLIYLMSTRASGVPDRFSGGGSGTDFTLKISRVEAEDVGVYYCQQLVEYPLTFGQGTKLEIK,DIVMTQSPLSNPVTLGQPVSISCRSS--KSLLYKD-GKTYLNWFLQRPGQSPQLLIYL--------MSTRASGVPDRFSGGGSG--TDFTLKISRVEAEDVGVYYCQQLVE-----------------------YPLTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YWMHWVRQAPGQGLEWIGNINPS---NGGTNYNEKFKSKATMTRDTSTSTAYMELSSLRSEDTAVYYCELMQ--------------------------GYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-168,palivizumab,QVTLRESGPALVKPTQTLTLTCTFSGFSLSTSGMSVGWIRQPPGKALEWLADIWWDDKKDYNPSLKSRLTISKDTSKNQVVLKVTNMDPADTATYYCARSMITNWYFDVWGAGTTVTVSS,DIQMTQSPSTLSASVGDRVTITCKCQLSVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKLEIK,DIQMTQSPSTLSASVGDRVTITCKCQ--LSVG-------YMHWYQQKPGKAPKLLIYD--------TSKLASGVPSRFSGSGSG--TEFTLTISSLQPDDFATYYCFQGSG-----------------------YPFTFGGGTKLEIK-,QVTLRES-GPALVKPTQTLTLTCTFSG-FSLSTS---GMSVGWIRQPPGKALEWLADIWW----DDKKDYNPSLKSRLTISKDTSKNQVVLKVTNMDPADTATYYCARSMITN--------------------WYFDVWGAGTTVTVSS,IgG1,Kappa,3
GDPa1-169,pamrevlumab,EGQLVQSGGGLVHPGGSLRLSCAGSGFTFSSYGMHWVRQAPGKGLEWVSGIGTGGGTYSTDSVKGRFTISRDNAKNSLYLQMNSLRAEDMAVYYCARGDYYGSGSFFDCWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIS------SWLAWYQQKPEKAPKSLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYNS-----------------------YPPTFGQGTKLEIK-,EGQLVQS-GGGLVHPGGSLRLSCAGSG-FTFSS-----YGMHWVRQAPGKGLEWVSGIGT----GGGTYSTDSVKGRFTISRDNAKNSLYLQMNSLRAEDMAVYYCARGDYYGS------------------GSFFDCWGQGTLVTVSS,IgG4,Kappa,1
GDPa1-170,panitumumab,QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSS,DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCQAS--QDIS------NYLNWYQQKPGKAPKLLIYD--------ASNLETGVPSRFSGSGSG--TDFTFTISSLQPEDIATYFCQHFDH-----------------------LPLAFGGGTKVEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-GSVSSG---DYYWTWIRQSPGKGLEWIGHIYY----SGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVT---------------------GAFDIWGQGTMVTVSS,IgG2,Kappa,1
GDPa1-171,panobacumab,EEQVVESGGGFVQPGGSLRLSCAASGFTFSPYWMHWVRQAPGKGLVWVSRINSDGSTYYADSVKGRFTISRDNARNTLYLQMNSLRAEDTAVYYCARDRYYGPEMWGQGTMVTVSS,DVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWPLTFGGGTKVEIK,DVVMTQSPLSLPVTLGQPASISCRSS--QSLVYSD-GNTYLNWFQQRPGQSPRRLIYK--------VSNRDSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCMQGTH-----------------------WPLTFGGGTKVEIK-,EEQVVES-GGGFVQPGGSLRLSCAASG-FTFSP-----YWMHWVRQAPGKGLVWVSRINS----DGSTYYADSVKGRFTISRDNARNTLYLQMNSLRAEDTAVYYCARDRYY----------------------GPEMWGQGTMVTVSS,IgG1,Kappa,1
GDPa1-172,parsatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGYTFIDYYMNWVRQAPGKGLEWVGDINLDNSGTHYNQKFKGRFTISRDKSKNTAYLQMNSLRAEDTAVYYCAREGVYHDYDDYAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRTSQSLVHINAITYLHWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCGQSTHVPLTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRTS--QSLVHIN-AITYLHWYQQKPGKAPKLLIYR--------VSNRFSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCGQSTH-----------------------VPLTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YTFID-----YYMNWVRQAPGKGLEWVGDINLD---NSGTHYNQKFKGRFTISRDKSKNTAYLQMNSLRAEDTAVYYCAREGVYHDY----------------DDYAMDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-173,patritumab,QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWTWYFDLWGRGTLVTVSS,DIEMTQSPDSLAVSLGERATINCRSSQSVLYSSSNRNYLAWYQQNPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPRTFGQGTKVEIK,DIEMTQSPDSLAVSLGERATINCRSS--QSVLYSSSNRNYLAWYQQNPGQPPKLLIYW--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQQYYS-----------------------TPRTFGQGTKVEIK-,QVQLQQW-GAGLLKPSETLSLTCAVYG-GSFSG-----YYWSWIRQPPGKGLEWIGEINH----SGSTNYNPSLKSRVTISVETSKNQFSLKLSSVTAADTAVYYCARDKWT---------------------WYFDLWGRGTLVTVSS,IgG1,Kappa,3
GDPa1-174,pembrolizumab,QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--KGVSTS--GYSYLHWYQQKPGQAPRLLIYL--------ASYLESGVPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQHSRD-----------------------LPLTFGGGTKVEIK-,QVQLVQS-GVEVKKPGASVKVSCKASG-YTFTN-----YYMYWVRQAPGQGLEWMGGINPS---NGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRF-------------------DMGFDYWGQGTTVTVSS,IgG4,Kappa,3
GDPa1-175,pertuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVS------IGVAWYQQKPGKAPKLLIYS--------ASYRYTGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYYI-----------------------YPYTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFTD-----YTMDWVRQAPGKGLEWVADVNPN---SGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPS--------------------FYFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-176,pidilizumab,QVQLVQSGSELKKPGASVKISCKASGYTFTNYGMNWVRQAPGQGLQWMGWINTDSGESTYAEEFKGRFVFSLDTSVNTAYLQITSLTAEDTGMYFCVRVGYDALDYWGQGTLVTVSS,EIVLTQSPSSLSASVGDRVTITCSARSSVSYMHWFQQKPGKAPKLWIYRTSNLASGVPSRFSGSGSGTSYCLTINSLQPEDFATYYCQQRSSFPLTFGGGTKLEIK,EIVLTQSPSSLSASVGDRVTITCSAR--SSVS-------YMHWFQQKPGKAPKLWIYR--------TSNLASGVPSRFSGSGSG--TSYCLTINSLQPEDFATYYCQQRSS-----------------------FPLTFGGGTKLEIK-,QVQLVQS-GSELKKPGASVKISCKASG-YTFTN-----YGMNWVRQAPGQGLQWMGWINTD---SGESTYAEEFKGRFVFSLDTSVNTAYLQITSLTAEDTGMYFCVRVGYD----------------------ALDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-177,pinatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGYEFSRSWMNWVRQAPGKGLEWVGRIYPGDGDTNYSGKFKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARDGSSWDWYFDVWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRSSQSIVHSVGNTFLEWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCFQGSQFPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRSS--QSIVHSV-GNTFLEWYQQKPGKAPKLLIYK--------VSNRFSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCFQGSQ-----------------------FPYTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YEFSR-----SWMNWVRQAPGKGLEWVGRIYPG---DGDTNYSGKFKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARDGSSW-------------------DWYFDVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-178,plozalizumab,EVQLVESGGGLVKPGGSLRLSCAASGFTFSAYAMNWVRQAPGKGLEWVGRIRTKNNNYATYYADSVKDRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTFYGNGVWGQGTLVTVSS,DVVMTQSPLSLPVTLGQPASISCKSSQSLLDSDGKTFLNWFQQRPGQSPRRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPYTFGQGTRLEIK,DVVMTQSPLSLPVTLGQPASISCKSS--QSLLDSD-GKTFLNWFQQRPGQSPRRLIYL--------VSKLDSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCWQGTH-----------------------FPYTFGQGTRLEIK-,EVQLVES-GGGLVKPGGSLRLSCAASG-FTFSA-----YAMNWVRQAPGKGLEWVGRIRTKN-NNYATYYADSVKDRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTFYG------------------------NGVWGQGTLVTVSS,IgG4,Kappa,4
GDPa1-179,polatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSS,DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIK,DIQLTQSPSSLSASVGDRVTITCKAS--QSVDYE--GDSFLNWYQQKPGKAPKLLIYA--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQSNE-----------------------DPLTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YTFSS-----YWIEWVRQAPGKGLEWIGEILPG---GGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPI----------------------RLDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-180,ponezumab,QVQLVQSGAEVKKPGASVKVSCKASGYYTEAYYIHWVRQAPGQGLEWMGRIDPATGNTKYAPRLQDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASLYSLPVYWGQGTTVTVSS,DVVMTQSPLSLPVTLGQPASISCKSSQSLLYSDAKTYLNWFQQRPGQSPRRLIYQISRLDPGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHYPVLFGQGTRLEIK,DVVMTQSPLSLPVTLGQPASISCKSS--QSLLYSD-AKTYLNWFQQRPGQSPRRLIYQ--------ISRLDPGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCLQGTH-----------------------YPVLFGQGTRLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YYTEA-----YYIHWVRQAPGQGLEWMGRIDPA---TGNTKYAPRLQDRVTMTRDTSTSTVYMELSSLRSEDTAVYYCASLYS-----------------------LPVYWGQGTTVTVSS,IgG2,Kappa,4
GDPa1-181,prasinezumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASISSGGGSTYYPDNVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARGGAGIDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKSIQTLLYSSNQKNYLAWFQQKPGKAPKLLIYWASIRKSGVPSRFSGSGSGTDFTLTISSLQPEDLATYYCQQYYSYPLTFGGGTKLEIK,DIQMTQSPSSLSASVGDRVTITCKSI--QTLLYSSNQKNYLAWFQQKPGKAPKLLIYW--------ASIRKSGVPSRFSGSGSG--TDFTLTISSLQPEDLATYYCQQYYS-----------------------YPLTFGGGTKLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSN-----YGMSWVRQAPGKGLEWVASISSG---GGSTYYPDNVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARGGA-----------------------GIDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-182,prezalumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVAYIKQDGNEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGILWFGDLPTFWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGISNWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYDSYPRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIS------NWLAWYQQKPEKAPKSLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYDS-----------------------YPRTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YWMSWVRQAPGKGLEWVAYIKQD---GNEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGILWF------------------GDLPTFWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-183,prolgolimab,QVQLVQSGGGLVQPGGSLRLSCAASGFTFSSYWMYWVRQVPGKGLEWVSAIDTGGGRTYYADSVKGRFAISRVNAKNTMYLQMNSLRAEDTAVYYCARDEGGGTGWGVLKDWPYGLDAWGQGTLVTVSS,QPVLTQPLSVSVALGQTARITCGGNNIGSKNVHWYQQKPGQAPVLVIYRDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQVWDSSTAVFGTGTKLTVL,QPVLTQP-LSVSVALGQTARITCGGN---NIGS-----KNVHWYQQKPGQAPVLVIYR--------DSNRPSGIPERFSGSNSG--NTATLTISRAQAGDEADYYCQVWDS-----------------------STAVFGTGTKLTVL-,QVQLVQS-GGGLVQPGGSLRLSCAASG-FTFSS-----YWMYWVRQVPGKGLEWVSAIDTG---GGRTYYADSVKGRFAISRVNAKNTMYLQMNSLRAEDTAVYYCARDEGGGTGWGV----------LKDWPYGLDAWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-184,quilizumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYGIAWVRQAPGKGLEWVAFISDLAYTIYYADTVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDNWDAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRSSQSLVHNNANTYLHWYQQKPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCSQNTLVPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRSS--QSLVHNN-ANTYLHWYQQKPGKAPKLLIYK--------VSNRFSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCSQNTL-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSD-----YGIAWVRQAPGKGLEWVAFISDL---AYTIYYADTVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDNWD----------------------AMDYWGQGTLVTVSS,IgG2,Kappa,2
GDPa1-185,racotumomab,QVQLQQSGAELVKPGASVKLSCKASGYTFTSYDINWVRQRPEQGLEWIGWIFPGDGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCAREDYYDNSYYFDYWGQGTTLTVSS,DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIK,DIQMTQTTSSLSASLGDRVTISCRAS--QDIS------NYLNWYQQKPDGTVKLLIYY--------TSRLHSGVPSRFSGSGSG--TDYSLTISNLEQEDIATYFCQQGNT-----------------------LPWTFGGGTKLEIK-,QVQLQQS-GAELVKPGASVKLSCKASG-YTFTS-----YDINWVRQRPEQGLEWIGWIFPG---DGSTKYNEKFKGKATLTTDKSSSTAYMQLSRLTSEDSAVYFCAREDYYDN------------------SYYFDYWGQGTTLTVSS,IgG1,Kappa,1
GDPa1-186,radretumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFSMSWVRQAPGKGLEWVSSISGSSGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPFPYFDYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIYYASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQTGRIPPTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SFLAWYQQKPGQAPRLLIYY--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQTGR-----------------------IPPTFGQGTKVEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSS-----FSMSWVRQAPGKGLEWVSSISGS---SGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPFP-----------------------YFDYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-187,ramucirumab,EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTDAFDIWGQGTMVTVSS,DIQMTQSPSSVSASIGDRVTITCRASQGIDNWLGWYQQKPGKAPKLLIYDASNLDTGVPSRFSGSGSGTYFTLTISSLQAEDFAVYFCQQAKAFPPTFGGGTKVDIK,DIQMTQSPSSVSASIGDRVTITCRAS--QGID------NWLGWYQQKPGKAPKLLIYD--------ASNLDTGVPSRFSGSGSG--TYFTLTISSLQAEDFAVYFCQQAKA-----------------------FPPTFGGGTKVDIK-,EVQLVQS-GGGLVKPGGSLRLSCAASG-FTFSS-----YSMNWVRQAPGKGLEWVSSISSS---SSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVTD-----------------------AFDIWGQGTMVTVSS,IgG1,Kappa,0
GDPa1-188,ranibizumab,EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSS,DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIK,DIQLTQSPSSLSASVGDRVTITCSAS--QDIS------NYLNWYQQKPGKAPKVLIYF--------TSSLHSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYST-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-YDFTH-----YGMNWVRQAPGKGLEWVGWINTY---TGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGT----------------SHWYFDVWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-189,relatlimab,QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSIS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSN-----------------------WPLTFGQGTNLEIK-,QVQLQQW-GAGLLKPSETLSLTCAVYG-GSFSD-----YYWNWIRQPPGKGLEWIGEINH----RGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYE------------------YNWFDPWGQGTLVTVSS,IgG4,Kappa,2
GDPa1-190,reslizumab,EVQLVESGGGLVQPGGSLRLSCAVSGLSLTSNSVNWIRQAPGKGLEWVGLIWSNGDTDYNSAIKSRFTISRDTSKSTVYLQMNSLRAEDTAVYYCAREYYGYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCLASEGISSYLAWYQQKPGKAPKLLIYGANSLQTGVPSRFSGSGSATDYTLTISSLQPEDFATYYCQQSYKFPNTFGQGTKVEVK,DIQMTQSPSSLSASVGDRVTITCLAS--EGIS------SYLAWYQQKPGKAPKLLIYG--------ANSLQTGVPSRFSGSGSA--TDYTLTISSLQPEDFATYYCQQSYK-----------------------FPNTFGQGTKVEVK-,EVQLVES-GGGLVQPGGSLRLSCAVSG-LSLTS-----NSVNWIRQAPGKGLEWVGLIWS----NGDTDYNSAIKSRFTISRDTSKSTVYLQMNSLRAEDTAVYYCAREYYG----------------------YFDYWGQGTLVTVSS,IgG4,Kappa,1
GDPa1-191,rilotumumab,QVQLQESGPGLVKPSETLSLTCTVSGGSISIYYWSWIRQPPGKGLEWIGYVYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCARGGYDFWSGYFDYWGQGTLVTVSS,EIVMTQSPATLSVSPGERATLSCRASQSVDSNLAWYRQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYINWPPITFGQGTRLEIK,EIVMTQSPATLSVSPGERATLSCRAS--QSVD------SNLAWYRQKPGQAPRLLIYG--------ASTRATGIPARFSGSGSG--TEFTLTISSLQSEDFAVYYCQQYINW----------------------PPITFGQGTRLEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-GSISI-----YYWSWIRQPPGKGLEWIGYVYY----SGSTNYNPSLKSRVTISVDTSKNQFSLKLNSVTAADTAVYYCARGGYDFW------------------SGYFDYWGQGTLVTVSS,IgG2,Kappa,1
GDPa1-192,rinucumab,QLQLQESGPGLVKPSETLSLTCTVSGGSITSSSYYWGWIRQPPGKGLEWIGSIYYRGSTNYNPSLKSRVTISVDSSKNQFYLKVSSVTAVDTAVYYCARQNGAARPSWFDPWGQGTLVTVSS,EIVLTQSPDTISLSPGERATLSCRASQSISSIYLAWYQQKPGQAPRLLIYGASSRVTGIPDRFSVSGSGTDFTLTISRLEPEDFAVYYCQHYGISPFTFGPGTKVDIR,EIVLTQSPDTISLSPGERATLSCRAS--QSISS-----IYLAWYQQKPGQAPRLLIYG--------ASSRVTGIPDRFSVSGSG--TDFTLTISRLEPEDFAVYYCQHYGI-----------------------SPFTFGPGTKVDIR-,QLQLQES-GPGLVKPSETLSLTCTVSG-GSITSS---SYYWGWIRQPPGKGLEWIGSIYY----RGSTNYNPSLKSRVTISVDSSKNQFYLKVSSVTAVDTAVYYCARQNGAAR------------------PSWFDPWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-193,risankizumab,QVQLVQSGAEVKKPGSSVKVSCKASGYTFTDQTIHWMRQAPGQGLEWIGYIYPRDDSPKYNENFKGKVTITADKSTSTAYMELSSLRSEDTAVYYCAIPDRSGYAWFIYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASRDVAIAVAWYQQKPGKVPKLLIYWASTRHTGVPSRFSGSGSRTDFTLTISSLQPEDVADYFCHQYSSYPFTFGSGTKLEIK,DIQMTQSPSSLSASVGDRVTITCKAS--RDVA------IAVAWYQQKPGKVPKLLIYW--------ASTRHTGVPSRFSGSGSR--TDFTLTISSLQPEDVADYFCHQYSS-----------------------YPFTFGSGTKLEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-YTFTD-----QTIHWMRQAPGQGLEWIGYIYPR---DDSPKYNENFKGKVTITADKSTSTAYMELSSLRSEDTAVYYCAIPDRSG-------------------YAWFIYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-194,rituximab,QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSA,QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIK,QIVLSQSPAILSASPGEKVTMTCRAS--SSVS-------YIHWFQQKPGSSPKPWIYA--------TSNLASGVPVRFSGSGSG--TSYSLTISRVEAEDAATYYCQQWTS-----------------------NPPTFGGGTKLEIK-,QVQLQQP-GAELVKPGASVKMSCKASG-YTFTS-----YNMHWVKQTPGRGLEWIGAIYPG---NGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGG------------------DWYFNVWGAGTTVTVSA,IgG1,Kappa,2
GDPa1-195,robatumumab,EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSFAMHWVRQAPGKGLEWISVIDTRGATYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGNFYYGMDVWGQGTTVTVSS,EIVLTQSPGTLSVSPGERATLSCRASQSIGSSLHWYQQKPGQAPRLLIKYASQSLSGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCHQSSRLPHTFGQGTKVEIK,EIVLTQSPGTLSVSPGERATLSCRAS--QSIG------SSLHWYQQKPGQAPRLLIKY--------ASQSLSGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCHQSSR-----------------------LPHTFGQGTKVEIK-,EVQLVQS-GGGLVKPGGSLRLSCAASG-FTFSS-----FAMHWVRQAPGKGLEWISVIDT----RGATYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARLGNFY--------------------YGMDVWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-196,romosozumab,EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMHWVRQAPGQGLEWMGEINPNSGGAGYNQKFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARLGYDDIYDDWYFDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGDTLPYTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDIS------NYLNWYQQKPGKAPKLLIYY--------TSRLLSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQGDT-----------------------LPYTFGGGTKVEIK-,EVQLVQS-GAEVKKPGASVKVSCKASG-YTFTD-----YNMHWVRQAPGQGLEWMGEINPN---SGGAGYNQKFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARLGYDDIY----------------DDWYFDVWGQGTTVTVSS,IgG2,Kappa,0
GDPa1-197,rontalizumab,EVQLVESGGGLVQPGGSLRLSCATSGYTFTEYIIHWVRQAPGKGLEWVASINPDYDITNYNQRFKGRFTISLDKSKRTAYLQMNSLRAEDTAVYYCASWISDFFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKVLISYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWGIPRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QSVSTS--SYSYMHWYQQKPGKAPKVLISY--------ASNLESGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQHSWG-----------------------IPRTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCATSG-YTFTE-----YIIHWVRQAPGKGLEWVASINPD---YDITNYNQRFKGRFTISLDKSKRTAYLQMNSLRAEDTAVYYCASWISD----------------------FFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-198,rovalpituzumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARIGDSSPSDYWGQGTLVTVSS,EIVMTQSPATLSVSPGERATLSCKASQSVSNDVVWYQQKPGQAPRLLIYYASNRYTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQDYTSPWTFGQGTKLEIK,EIVMTQSPATLSVSPGERATLSCKAS--QSVS------NDVVWYQQKPGQAPRLLIYY--------ASNRYTGIPARFSGSGSG--TEFTLTISSLQSEDFAVYYCQQDYT-----------------------SPWTFGQGTKLEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----YGMNWVRQAPGQGLEWMGWINTY---TGEPTYADDFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARIGDS---------------------SPSDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-199,rozanolixizumab,EVPLVESGGGLVQPGGSLRLSCAVSGFTFSNYGMVWVRQAPGKGLEWVAYIDSDGDNTYYRDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCTTGIVRPFLYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKSSQSLVGASGKTYLYWLFQKPGKAPKRLIYLVSTLDSGIPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQGTHFPHTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCKSS--QSLVGAS-GKTYLYWLFQKPGKAPKRLIYL--------VSTLDSGIPSRFSGSGSG--TEFTLTISSLQPEDFATYYCLQGTH-----------------------FPHTFGQGTKLEIK-,EVPLVES-GGGLVQPGGSLRLSCAVSG-FTFSN-----YGMVWVRQAPGKGLEWVAYIDSD---GDNTYYRDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCTTGIVR----------------------PFLYWGQGTLVTVSS,IgG4,Kappa,1
GDPa1-200,sarilumab,EVQLVESGGGLVQPGRSLRLSCAASRFTFDDYAMHWVRQAPGKGLEWVSGISWNSGRIGYADSVKGRFTISRDNAENSLFLQMNGLRAEDTALYYCAKGRDSFDIWGQGTMVTVSS,DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYGASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFASYYCQQANSFPYTFGQGTKLEIK,DIQMTQSPSSVSASVGDRVTITCRAS--QGIS------SWLAWYQQKPGKAPKLLIYG--------ASSLESGVPSRFSGSGSG--TDFTLTISSLQPEDFASYYCQQANS-----------------------FPYTFGQGTKLEIK-,EVQLVES-GGGLVQPGRSLRLSCAASR-FTFDD-----YAMHWVRQAPGKGLEWVSGISWN---SGRIGYADSVKGRFTISRDNAENSLFLQMNGLRAEDTALYYCAKGRD-----------------------SFDIWGQGTMVTVSS,IgG1,Kappa,0
GDPa1-201,satralizumab,QVQLQESGPGLVKPSETLSLTCAVSGHSISHDHAWSWVRQPPGEGLEWIGFISYSGITNYNPSLQGRVTISRDNSKNTLYLQMNSLRAEDTAVYYCARSLARTTAMDYWGEGTLVTVSS,DIQMTQSPSSLSASVGDSVTITCQASTDISSHLNWYQQKPGKAPELLIYYGSHLLSGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCGQGNRLPYTFGQGTKVEIE,DIQMTQSPSSLSASVGDSVTITCQAS--TDIS------SHLNWYQQKPGKAPELLIYY--------GSHLLSGVPSRFSGSGSG--TDFTFTISSLEAEDAATYYCGQGNR-----------------------LPYTFGQGTKVEIE-,QVQLQES-GPGLVKPSETLSLTCAVSG-HSISH----DHAWSWVRQPPGEGLEWIGFISY----SGITNYNPSLQGRVTISRDNSKNTLYLQMNSLRAEDTAVYYCARSLART--------------------TAMDYWGEGTLVTVSS,IgG2,Kappa,1
GDPa1-202,secukinumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPCTFGQGTRLEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----SYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------SPCTFGQGTRLEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSN-----YWMNWVRQAPGKGLEWVAAINQD---GSEKYYVGSVKGRFTISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDY------------YIHYWYFDLWGRGTLVTVSS,IgG1,Kappa,2
GDPa1-203,selicrelumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPDSGGTNYAQKFQGRVTMTRDTSISTAYMELNRLRSDDTAVYYCARDQPLGYCTNGVCSYFDYWGQGTLVTVSS,DIQMTQSPSSVSASVGDRVTITCRASQGIYSWLAWYQQKPGKAPNLLIYTASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANIFPLTFGGGTKVEIK,DIQMTQSPSSVSASVGDRVTITCRAS--QGIY------SWLAWYQQKPGKAPNLLIYT--------ASTLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQANI-----------------------FPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTG-----YYMHWVRQAPGQGLEWMGWINPD---SGGTNYAQKFQGRVTMTRDTSISTAYMELNRLRSDDTAVYYCARDQPLGYCT-------------NGVCSYFDYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-204,seribantumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYVMAWVRQAPGKGLEWVSSISSSGGWTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMATIFDYWGQGTLVTVSS,QSALTQPASVSGSPGQSITISCTGTSSDVGSYNVVSWYQQHPGKAPKLIIYEVSQRPSGVSNRFSGSKSGNTASLTISGLQTEDEADYYCCSYAGSSIFVIFGGGTKVTVL,QSALTQP-ASVSGSPGQSITISCTGTS-SDVGS----YNVVSWYQQHPGKAPKLIIYE--------VSQRPSGVSNRFSGSKSG--NTASLTISGLQTEDEADYYCCSYAGS---------------------SIFVIFGGGTKVTVL-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSH-----YVMAWVRQAPGKGLEWVSSISSS---GGWTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMA--------------------TIFDYWGQGTLVTVSS,IgG2,Lambda,3
GDPa1-205,setrusumab,QVQLVESGGGLVQPGGSLRLSCAASGFTFRSHWLSWVRQAPGKGLEWVSNINYDGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYLHFDYWGQGTLVTVSS,DIALTQPASVSGSPGQSITISCTGTSSDVGDINDVSWYQQHPGKAPKLMIYDVNNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCQSYAGSYLSEVFGGGTKLTVL,DIALTQP-ASVSGSPGQSITISCTGTS-SDVGD----INDVSWYQQHPGKAPKLMIYD--------VNNRPSGVSNRFSGSKSG--NTASLTISGLQAEDEADYYCQSYAGS---------------------YLSEVFGGGTKLTVL-,QVQLVES-GGGLVQPGGSLRLSCAASG-FTFRS-----HWLSWVRQAPGKGLEWVSNINYD---GSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDTYL----------------------HFDYWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-206,sifalimumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYSISWVRQAPGQGLEWMGWISVYNGNTNYAQKFQGRVTMTTDTSTSTAYLELRSLRSDDTAVYYCARDPIAAGYWGQGTLVTVSS,EIVLTQSPGTLSLSPGERATLSCRASQSVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPRTFGQGTKVEIK,EIVLTQSPGTLSLSPGERATLSCRAS--QSVSS-----TYLAWYQQKPGQAPRLLIYG--------ASSRATGIPDRFSGSGSG--TDFTLTISRLEPEDFAVYYCQQYGS-----------------------SPRTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTS-----YSISWVRQAPGQGLEWMGWISVY---NGNTNYAQKFQGRVTMTTDTSTSTAYLELRSLRSDDTAVYYCARDPI-----------------------AAGYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-207,siltuximab,EVQLVESGGKLLKPGGSLKLSCAASGFTFSSFAMSWFRQSPEKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGYYALDYWGQGTSVTVSS,QIVLIQSPAIMSASPGEKVTMTCSASSSVSYMYWYQQKPGSSPRLLIYDTSNLASGVPVRFSGSGSGTSYSLTISRMEAEDAATYYCQQWSGYPYTFGGGTKLEIK,QIVLIQSPAIMSASPGEKVTMTCSAS--SSVS-------YMYWYQQKPGSSPRLLIYD--------TSNLASGVPVRFSGSGSG--TSYSLTISRMEAEDAATYYCQQWSG-----------------------YPYTFGGGTKLEIK-,EVQLVES-GGKLLKPGGSLKLSCAASG-FTFSS-----FAMSWFRQSPEKRLEWVAEISSG---GSYTYYPDTVTGRFTISRDNAKNTLYLEMSSLRSEDTAMYYCARGLWGY--------------------YALDYWGQGTSVTVSS,IgG1,Kappa,3
GDPa1-208,simtuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYAFTYYLIEWVRQAPGQGLEWIGVINPGSGGTNYNEKFKGRATITADKSTSTAYMELSSLRSEDTAVYFCARNWMNFDYWGQGTTVTVSS,DIVMTQTPLSLSVTPGQPASISCRSSKSLLHSNGNTYLYWFLQKPGQSPQFLIYRMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQHLEYPYTFGGGTKVEIK,DIVMTQTPLSLSVTPGQPASISCRSS--KSLLHSN-GNTYLYWFLQKPGQSPQFLIYR--------MSNLASGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCMQHLE-----------------------YPYTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YAFTY-----YLIEWVRQAPGQGLEWIGVINPG---SGGTNYNEKFKGRATITADKSTSTAYMELSSLRSEDTAVYFCARNWM-----------------------NFDYWGQGTTVTVSS,IgG4,Kappa,4
GDPa1-209,sintilimab,QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGLIIPMFDTAGYAQKFQGRVAITVDESTSTAYMELSSLRSEDTAVYYCARAEHSSTGTFDYWGQGTLVTVSS,DIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLISAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANHLPFTFGGGTKVEIK,DIQMTQSPSSVSASVGDRVTITCRAS--QGIS------SWLAWYQQKPGKAPKLLISA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQANH-----------------------LPFTFGGGTKVEIK-,QVQLVQS-GAEVKKPGSSVKVSCKASG-GTFSS-----YAISWVRQAPGQGLEWMGLIIPM---FDTAGYAQKFQGRVAITVDESTSTAYMELSSLRSEDTAVYYCARAEHSS-------------------TGTFDYWGQGTLVTVSS,IgG4,Kappa,0
GDPa1-210,sirukumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSPFAMSWVRQAPGKGLEWVAKISPGGSWTYYSDTVTGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLWGYYALDIWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCSASISVSYMYWYQQKPGQAPRLLIYDMSNLASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCMQWSGYPYTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCSAS--ISVS-------YMYWYQQKPGQAPRLLIYD--------MSNLASGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCMQWSG-----------------------YPYTFGGGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSP-----FAMSWVRQAPGKGLEWVAKISPG---GSWTYYSDTVTGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQLWGY--------------------YALDIWGQGTTVTVSS,IgG1,Kappa,2
GDPa1-211,solanezumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYSMSWVRQAPGKGLELVAQINSVGNSTYYPDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCASGDYWGQGTLVTVSS,DVVMTQSPLSLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKPGQSPRLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIK,DVVMTQSPLSLPVTLGQPASISCRSS--QSLIYSD-GNAYLHWFLQKPGQSPRLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCSQSTH-----------------------VPWTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSR-----YSMSWVRQAPGKGLELVAQINSV---GNSTYYPDTVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCASG---------------------------DYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-212,spartalizumab,EVQLVQSGAEVKKPGESLRISCKGSGYTFTTYWMHWVRQATGQGLEWMGNIYPGTGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTGTGAYWGQGTTVTVSS,EIVLTQSPATLSLSPGERATLSCKSSQSLLDSGNQKNFLTWYQQKPGQAPRLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQNDYSYPYTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCKSS--QSLLDSGNQKNFLTWYQQKPGQAPRLLIYW--------ASTRESGVPSRFSGSGSG--TDFTFTISSLEAEDAATYYCQNDYS-----------------------YPYTFGQGTKVEIK-,EVQLVQS-GAEVKKPGESLRISCKGSG-YTFTT-----YWMHWVRQATGQGLEWMGNIYPG---TGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTG----------------------TGAYWGQGTTVTVSS,IgG4,Kappa,3
GDPa1-213,sutimlimab,EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVATISSGGSHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTALYYCARLFTGYAMDYWGQGTLVTVSS,QIVLTQSPATLSLSPGERATMSCTASSSVSSSYLHWYQQKPGKAPKLWIYSTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCHQYYRLPPITFGQGTKLEIK,QIVLTQSPATLSLSPGERATMSCTAS--SSVSS-----SYLHWYQQKPGKAPKLWIYS--------TSNLASGVPSRFSGSGSG--TDYTLTISSLQPEDFATYYCHQYYRL----------------------PPITFGQGTKLEIK-,EVQLVES-GGGLVKPGGSLRLSCAASG-FTFSN-----YAMSWVRQAPGKGLEWVATISSG---GSHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTALYYCARLFTG---------------------YAMDYWGQGTLVTVSS,IgG4,Kappa,3
GDPa1-214,tabalumab,QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGYYDILTGYYYYFDYWGQGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSRYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDSTLTISSLEPEDFAVYYCQQRSNWPRTFGQGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------RYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDSTLTISSLEPEDFAVYYCQQRSN-----------------------WPRTFGQGTKVEIK-,QVQLQQW-GAGLLKPSETLSLTCAVYG-GSFSG-----YYWSWIRQPPGKGLEWIGEINH----SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGYYDILT---------------GYYYYFDYWGQGTLVTVSS,IgG4,Kappa,2
GDPa1-215,tanezumab,QVQLQESGPGLVKPSETLSLTCTVSGFSLIGYDLNWIRQPPGKGLEWIGIIWGDGTTDYNSAVKSRVTISKDTSKNQFSLKLSSVTAADTAVYYCARGGYWYATSYYFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQSISNNLNWYQQKPGKAPKLLIYYTSRFHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQEHTLPYTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QSIS------NNLNWYQQKPGKAPKLLIYY--------TSRFHSGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCQQEHT-----------------------LPYTFGQGTKLEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-FSLIG-----YDLNWIRQPPGKGLEWIGIIWG----DGTTDYNSAVKSRVTISKDTSKNQFSLKLSSVTAADTAVYYCARGGYWYA-----------------TSYYFDYWGQGTLVTVSS,IgG2,Kappa,1
GDPa1-216,tarextumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSGMSWVRQAPGKGLEWVSVIASSGSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSIFYTTWGQGTLVTVSS,DIVLTQSPATLSLSPGERATLSCRASQSVRSNYLAWYQQKPGQAPRLLIYGASSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNFPITFGQGTKVEIK,DIVLTQSPATLSLSPGERATLSCRAS--QSVRS-----NYLAWYQQKPGQAPRLLIYG--------ASSRATGVPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQYSN-----------------------FPITFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----SGMSWVRQAPGKGLEWVSVIASS---GSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSIF------------------------YTTWGQGTLVTVSS,IgG2,Kappa,4
GDPa1-217,tavolimab,QVQLQESGPGLVKPSQTLSLTCAVYGGSFSSGYWNWIRKHPGKGLEYIGYISYNGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYDGGHAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGSALPWTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDIS------NYLNWYQQKPGKAPKLLIYY--------TSKLHSGVPSRFSGSGSG--TDYTLTISSLQPEDFATYYCQQGSA-----------------------LPWTFGQGTKVEIK-,QVQLQES-GPGLVKPSQTLSLTCAVYG-GSFSS-----GYWNWIRKHPGKGLEYIGYISY----NGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYD-----------------GGHAMDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-218,telisotuzumab,QVQLVQSGAEVKKPGASVKVSCKASGYIFTAYTMHWVRQAPGQGLEWMGWIKPNNGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEITTEFDYWGQGTLVTVSS,DIVMTQSPDSLAVSLGERATINCKSSESVDSYANSFLHWYQQKPGQPPKLLIYRASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEDPLTFGGGTKVEIK,DIVMTQSPDSLAVSLGERATINCKSS--ESVDSY--ANSFLHWYQQKPGQPPKLLIYR--------ASTRESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQQSKE-----------------------DPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YIFTA-----YTMHWVRQAPGQGLEWMGWIKPN---NGLANYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARSEIT---------------------TEFDYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-219,teplizumab,QVQLVQSGGGVVQPGRSLRLSCKASGYTFTRYTMHWVRQAPGKGLEWIGYINPSRGYTNYNQKVKDRFTISRDNSKNTAFLQMDSLRPEDTGVYFCARYYDDHYCLDYWGQGTPVTVSS,DIQMTQSPSSLSASVGDRVTITCSASSSVSYMNWYQQTPGKAPKRWIYDTSKLASGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQWSSNPFTFGQGTKLQIT,DIQMTQSPSSLSASVGDRVTITCSAS--SSVS-------YMNWYQQTPGKAPKRWIYD--------TSKLASGVPSRFSGSGSG--TDYTFTISSLQPEDIATYYCQQWSS-----------------------NPFTFGQGTKLQIT-,QVQLVQS-GGGVVQPGRSLRLSCKASG-YTFTR-----YTMHWVRQAPGKGLEWIGYINPS---RGYTNYNQKVKDRFTISRDNSKNTAFLQMDSLRPEDTGVYFCARYYDDH--------------------YCLDYWGQGTPVTVSS,IgG1,Kappa,1
GDPa1-220,teprotumumab,QVELVESGGGVVQPGRSQRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAIIWFDGSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGRRYFDLWGRGTLVSVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSKWPPWTFGQGTKVESK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASKRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSKW----------------------PPWTFGQGTKVESK-,QVELVES-GGGVVQPGRSQRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAIIWFD---GSSTYYADSVRGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCARELGR---------------------RYFDLWGRGTLVSVSS,IgG1,Kappa,2
GDPa1-221,tezepelumab,QMQLVESGGGVVQPGRSLRLSCAASGFTFRTYGMHWVRQAPGKGLEWVAVIWYDGSNKHYADSVKGRFTITRDNSKNTLNLQMNSLRAEDTAVYYCARAPQWELVHEAFDIWGQGTMVTVSS,SYVLTQPPSVSVAPGQTARITCGGNNLGSKSVHWYQQKPGQAPVLVVYDDSDRPSWIPERFSGSNSGNTATLTISRGEAGDEADYYCQVWDSSSDHVVFGGGTKLTVL,SYVLTQP-PSVSVAPGQTARITCGGN---NLGS-----KSVHWYQQKPGQAPVLVVYD--------DSDRPSWIPERFSGSNSG--NTATLTISRGEAGDEADYYCQVWDSS---------------------SDHVVFGGGTKLTVL-,QMQLVES-GGGVVQPGRSLRLSCAASG-FTFRT-----YGMHWVRQAPGKGLEWVAVIWYD---GSNKHYADSVKGRFTITRDNSKNTLNLQMNSLRAEDTAVYYCARAPQWEL-----------------VHEAFDIWGQGTMVTVSS,IgG2,Lambda,3
GDPa1-222,tigatuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYVMSWVRQAPGKGLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARRGDSMITTDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSSYRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCKAS--QDVG------TAVAWYQQKPGKAPKLLIYW--------ASTRHTGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYSS------------------------YRTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FTFSS-----YVMSWVRQAPGKGLEWVATISSG---GSYTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARRGDSM--------------------ITTDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-223,tildrakizumab,QVQLVQSGAEVKKPGASVKVSCKASGYIFITYWMTWVRQAPGQGLEWMGQIFPASGSADYNEKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGGGFAYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRTSENIYSYLAWYQQKPGKAPKLLIYNAKTLAEGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYGIPFTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRTS--ENIY------SYLAWYQQKPGKAPKLLIYN--------AKTLAEGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQHHYG-----------------------IPFTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YIFIT-----YWMTWVRQAPGQGLEWMGQIFPA---SGSADYNEKFEGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARGGG-----------------------GFAYWGQGTLVTVSS,IgG1,Kappa,1
GDPa1-224,tislelizumab,QVQLQESGPGLVKPSETLSLTCTVSGFSLTSYGVHWIRQPPGKGLEWIGVIYADGSTNYNPSLKSRVTISKDTSKNQVSLKLSSVTAADTAVYYCARAYGNYWYIDVWGQGTTVTVSS,DIVMTQSPDSLAVSLGERATINCKSSESVSNDVAWYQQKPGQPPKLLINYAFHRFTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYYCHQAYSSPYTFGQGTKLEIK,DIVMTQSPDSLAVSLGERATINCKSS--ESVS------NDVAWYQQKPGQPPKLLINY--------AFHRFTGVPDRFSGSGYG--TDFTLTISSLQAEDVAVYYCHQAYS-----------------------SPYTFGQGTKLEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-FSLTS-----YGVHWIRQPPGKGLEWIGVIYA----DGSTNYNPSLKSRVTISKDTSKNQVSLKLSSVTAADTAVYYCARAYGNY--------------------WYIDVWGQGTTVTVSS,IgG4,Kappa,2
GDPa1-225,tisotumab,EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSSISGSGDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWGYYLDSWGQGTLVTVSS,DIQMTQSPPSLSASAGDRVTITCRASQGISSRLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPYTFGQGTKLEIK,DIQMTQSPPSLSASAGDRVTITCRAS--QGIS------SRLAWYQQKPEKAPKSLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYNS-----------------------YPYTFGQGTKLEIK-,EVQLLES-GGGLVQPGGSLRLSCAASG-FTFSN-----YAMSWVRQAPGKGLEWVSSISGS---GDYTYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSPWG---------------------YYLDSWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-226,tocilizumab,QVQLQESGPGLVRPSQTLSLTCTVSGYSITSDHAWSWVRQPPGRGLEWIGYISYSGITTYNPSLKSRVTMLRDTSKNQFSLRLSSVTAADTAVYYCARSLARTTAMDYWGQGSLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDISSYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQGNTLPYTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDIS------SYLNWYQQKPGKAPKLLIYY--------TSRLHSGVPSRFSGSGSG--TDFTFTISSLQPEDIATYYCQQGNT-----------------------LPYTFGQGTKVEIK-,QVQLQES-GPGLVRPSQTLSLTCTVSG-YSITS----DHAWSWVRQPPGRGLEWIGYISY----SGITTYNPSLKSRVTMLRDTSKNQFSLRLSSVTAADTAVYYCARSLART--------------------TAMDYWGQGSLVTVSS,IgG1,Kappa,3
GDPa1-227,toripalimab,QGQLVQSGAEVKKPGASVKVSCKASGYTFTDYEMHWVRQAPIHGLEWIGVIESETGGTAYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCAREGITTVATTYYWYFDVWGQGTTVTVSS,DVVMTQSPLSLPVTLGQPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPLTFGQGTKLEIK,DVVMTQSPLSLPVTLGQPASISCRSS--QSIVHSN-GNTYLEWYLQKPGQSPQLLIYK--------VSNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCFQGSH-----------------------VPLTFGQGTKLEIK-,QGQLVQS-GAEVKKPGASVKVSCKASG-YTFTD-----YEMHWVRQAPIHGLEWIGVIESE---TGGTAYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCAREGITTVAT--------------TYYWYFDVWGQGTTVTVSS,IgG4,Kappa,4
GDPa1-228,tovetumab,QVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMNWIRQAPGKGLEWVSYISSSGSIIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGRIAARGMDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVSITCRPSQSFSRYINWYQQKPGKAPKLLIHAASSLVGGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQTYSNPPITFGQGTRLEMK,DIQMTQSPSSLSASVGDRVSITCRPS--QSFS------RYINWYQQKPGKAPKLLIHA--------ASSLVGGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQTYSN----------------------PPITFGQGTRLEMK-,QVQLVES-GGGLVKPGGSLRLSCAASG-FTFSD-----YYMNWIRQAPGKGLEWVSYISSS---GSIIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGRIA-------------------ARGMDVWGQGTTVTVSS,IgG2,Kappa,2
GDPa1-229,tralokinumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGLSWVRQAPGQGLEWMGWISANNGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSWARWFFDLWGRGTLVTVSS,SYVLTQPPSVSVAPGKTARITCGGNIIGSKLVHWYQQKPGQAPVLVIYDDGDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDTGSDPVVFGGGTKLTVL,SYVLTQP-PSVSVAPGKTARITCGGN---IIGS-----KLVHWYQQKPGQAPVLVIYD--------DGDRPSGIPERFSGSNSG--NTATLTISRVEAGDEADYYCQVWDTG---------------------SDPVVFGGGTKLTVL-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----YGLSWVRQAPGQGLEWMGWISAN---NGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSW-----------------ARWFFDLWGRGTLVTVSS,IgG4,Lambda,2
GDPa1-230,trastuzumab,EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QDVN------TAVAWYQQKPGKAPKLLIYS--------ASFLYSGVPSRFSGSRSG--TDFTLTISSLQPEDFATYYCQQHYT-----------------------TPPTFGQGTKVEIK-,EVQLVES-GGGLVQPGGSLRLSCAASG-FNIKD-----TYIHWVRQAPGKGLEWVARIYPT---NGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDG-------------------FYAMDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-231,tregalizumab,EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGVISVKSENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYDVGAWFAYWGQGTLVTVSS,DIVMTQSPDSLAVSLGERATINCRASKSVSTSGYSYIYWYQQKPGQPPKLLIYLASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPWTFGQGTKVEIK,DIVMTQSPDSLAVSLGERATINCRAS--KSVSTS--GYSYIYWYQQKPGQPPKLLIYL--------ASILESGVPDRFSGSGSG--TDFTLTISSLQAEDVAVYYCQHSRE-----------------------LPWTFGQGTKVEIK-,EEQLVES-GGGLVKPGGSLRLSCAASG-FSFSD-----CRMYWLRQAPGKGLEWIGVISVKS-ENYGANYAESVRGRFTISRDDSKNTVYLQMNSLKTEDTAVYYCSASYYRYD-----------------VGAWFAYWGQGTLVTVSS,IgG1,Kappa,2
GDPa1-232,tremelimumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QSIN------SYLDWYQQKPGKAPKLLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYYS-----------------------TPFTFGPGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YGMHWVRQAPGKGLEWVAVIWYD---GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLY--------------YYYYGMDVWGQGTTVTVSS,IgG2,Kappa,2
GDPa1-233,ublituximab,QAYLQQSGAELVRPGASVKMSCKASGYTFTSYNMHWVKQTPRQGLEWIGGIYPGNGDTSYNQKFKGKATLTVGKSSSTAYMQLSSLTSEDSAVYFCARYDYNYAMDYWGQGTSVTVSS,QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSFTISRVEAEDAATYYCQQWTFNPPTFGGGTRLEIK,QIVLSQSPAILSASPGEKVTMTCRAS--SSVS-------YMHWYQQKPGSSPKPWIYA--------TSNLASGVPARFSGSGSG--TSYSFTISRVEAEDAATYYCQQWTF-----------------------NPPTFGGGTRLEIK-,QAYLQQS-GAELVRPGASVKMSCKASG-YTFTS-----YNMHWVKQTPRQGLEWIGGIYPG---NGDTSYNQKFKGKATLTVGKSSSTAYMQLSSLTSEDSAVYFCARYDYN---------------------YAMDYWGQGTSVTVSS,IgG1,Kappa,2
GDPa1-234,urelumab,QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSS,EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFGGGTKVEIK,EIVLTQSPATLSLSPGERATLSCRAS--QSVS------SYLAWYQQKPGQAPRLLIYD--------ASNRATGIPARFSGSGSG--TDFTLTISSLEPEDFAVYYCQQRSNW---------------------PPALTFGGGTKVEIK-,QVQLQQW-GAGLLKPSETLSLTCAVYG-GSFSG-----YYWSWIRQSPEKGLEWIGEINH----GGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGN-----------------YDWYFDLWGRGTLVTVSS,IgG4,Kappa,2
GDPa1-235,ustekinumab,EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPYTFGQGTKLEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIS------SWLAWYQQKPEKAPKSLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYNI-----------------------YPYTFGQGTKLEIK-,EVQLVQS-GAEVKKPGESLKISCKGSG-YSFTT-----YWLGWVRQMPGKGLDWIGIMSPV---DSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQ--------------------GYFDFWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-236,utomilumab,EVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSS,SYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVL,SYELTQP-PSVSVSPGQTASITCSGD---NIGD-----QYAHWYQQKPGQSPVLVIYQ--------DKNRPSGIPERFSGSNSG--NTATLTISGTQAMDEADYYCATYTGF---------------------GSLAVFGGGTKLTVL-,EVQLVQS-GAEVKKPGESLRISCKGSG-YSFST-----YWISWVRQMPGKGLEWMGKIYPG---DSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYG-----------------------IFDYWGQGTLVTVSS,IgG2,Lambda,3
GDPa1-237,vadastuximab,QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYDINWVRQAPGQGLEWIGWIYPGDGSTKYNEKFKAKATLTADTSTSTAYMELRSLRSDDTAVYYCASGYEDAMDYWGQGTTVTVSS,DIQMTQSPSSLSASVGDRVTINCKASQDINSYLSWFQQKPGKAPKTLIYRANRLVDGVPSRFSGSGSGQDYTLTISSLQPEDFATYYCLQYDEFPLTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTINCKAS--QDIN------SYLSWFQQKPGKAPKTLIYR--------ANRLVDGVPSRFSGSGSG--QDYTLTISSLQPEDFATYYCLQYDE-----------------------FPLTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFTN-----YDINWVRQAPGQGLEWIGWIYPG---DGSTKYNEKFKAKATLTADTSTSTAYMELRSLRSDDTAVYYCASGYED----------------------AMDYWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-238,varlilumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSGNWGFFDYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCRASQGISRWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPRTFGQGTKVEIK,DIQMTQSPSSLSASVGDRVTITCRAS--QGIS------RWLAWYQQKPEKAPKSLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQYNT-----------------------YPRTFGQGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFSS-----YDMHWVRQAPGKGLEWVAVIWYD---GSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGSGNW--------------------GFFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-239,vatelizumab,QVQLQESGPGLVKPSETLSLTCTVSGFSLTNYGIHWIRQPPGKGLEWLGVIWARGFTNYNSALMSRLTISKDNSKNQVSLKLSSVTAADTAVYYCARANDGVYYAMDYWGQGTLVTVSS,DFVMTQSPAFLSVTPGEKVTITCSAQSSVNYIHWYQQKPDQAPKKLIYDTSKLASGVPSRFSGSGSGTDYTFTISSLEAEDAATYYCQQWTTNPLTFGQGTKVEIK,DFVMTQSPAFLSVTPGEKVTITCSAQ--SSVN-------YIHWYQQKPDQAPKKLIYD--------TSKLASGVPSRFSGSGSG--TDYTFTISSLEAEDAATYYCQQWTT-----------------------NPLTFGQGTKVEIK-,QVQLQES-GPGLVKPSETLSLTCTVSG-FSLTN-----YGIHWIRQPPGKGLEWLGVIWA----RGFTNYNSALMSRLTISKDNSKNQVSLKLSSVTAADTAVYYCARANDGV-------------------YYAMDYWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-240,vedolizumab,QVQLVQSGAEVKKPGASVKVSCKGSGYTFTSYWMHWVRQAPGQRLEWIGEIDPSESNTNYNQKFKGRVTLTVDISASTAYMELSSLRSEDTAVYYCARGGYDGWDYAIDYWGQGTLVTVSS,DVVMTQSPLSLPVTPGEPASISCRSSQSLAKSYGNTYLSWYLQKPGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCLQGTHQPYTFGQGTKVEIK,DVVMTQSPLSLPVTPGEPASISCRSS--QSLAKSY-GNTYLSWYLQKPGQSPQLLIYG--------ISNRFSGVPDRFSGSGSG--TDFTLKISRVEAEDVGVYYCLQGTH-----------------------QPYTFGQGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKGSG-YTFTS-----YWMHWVRQAPGQRLEWIGEIDPS---ESNTNYNQKFKGRVTLTVDISASTAYMELSSLRSEDTAVYYCARGGYDGW------------------DYAIDYWGQGTLVTVSS,IgG1,Kappa,4
GDPa1-241,veltuzumab,QVQLQQSGAEVKKPGSSVKVSCKASGYTFTSYNMHWVKQAPGQGLEWIGAIYPGMGDTSYNQKFKGKATLTADESTNTAYMELSSLRSEDTAFYYCARSTYYGGDWYFDVWGQGTTVTVSS,DIQLTQSPSSLSASVGDRVTMTCRASSSVSYIHWFQQKPGKAPKPWIYATSNLASGVPVRFSGSGSGTDYTFTISSLQPEDIATYYCQQWTSNPPTFGGGTKLEIK,DIQLTQSPSSLSASVGDRVTMTCRAS--SSVS-------YIHWFQQKPGKAPKPWIYA--------TSNLASGVPVRFSGSGSG--TDYTFTISSLQPEDIATYYCQQWTS-----------------------NPPTFGGGTKLEIK-,QVQLQQS-GAEVKKPGSSVKVSCKASG-YTFTS-----YNMHWVKQAPGQGLEWIGAIYPG---MGDTSYNQKFKGKATLTADESTNTAYMELSSLRSEDTAFYYCARSTYYGG------------------DWYFDVWGQGTTVTVSS,IgG1,Kappa,1
GDPa1-242,visilizumab,QVQLVQSGAEVKKPGASVKVSCKASGYTFISYTMHWVRQAPGQGLEWMGYINPRSGYTHYNQKLKDKATLTADKSASTAYMELSSLRSEDTAVYYCARSAYYDYDGFAYWGQGTLVTVSS,DIQMTQSPSSLSASVGDRVTITCSASSSVSYMNWYQQKPGKAPKRLIYDTSKLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSNPPTFGGGTKVEIK,DIQMTQSPSSLSASVGDRVTITCSAS--SSVS-------YMNWYQQKPGKAPKRLIYD--------TSKLASGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQWSS-----------------------NPPTFGGGTKVEIK-,QVQLVQS-GAEVKKPGASVKVSCKASG-YTFIS-----YTMHWVRQAPGQGLEWMGYINPR---SGYTHYNQKLKDKATLTADKSASTAYMELSSLRSEDTAVYYCARSAYYD-------------------YDGFAYWGQGTLVTVSS,IgG2,Kappa,0
GDPa1-243,xentuzumab,QVELVESGGGLVQPGGSLRLSCAASGFTFTSYWMSWVRQAPGKGLELVSSITSYGSFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNMYTHFDSWGQGTLVTVSS,DIVLTQPPSVSGAPGQRVTISCSGSSSNIGSNSVSWYQQLPGTAPKLLIYDNSKRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCQSRDTYGYYWVFGGGTKLTVL,DIVLTQP-PSVSGAPGQRVTISCSGSS-SNIGS-----NSVSWYQQLPGTAPKLLIYD--------NSKRPSGVPDRFSGSKSG--TSASLAITGLQSEDEADYYCQSRDTY---------------------GYYWVFGGGTKLTVL-,QVELVES-GGGLVQPGGSLRLSCAASG-FTFTS-----YWMSWVRQAPGKGLELVSSITSY---GSFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARNMYT----------------------HFDSWGQGTLVTVSS,IgG1,Lambda,4
GDPa1-244,zalutumumab,QVQLVESGGGVVQPGRSLRLSCAASGFTFSTYGMHWVRQAPGKGLEWVAVIWDDGSYKYYGDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGITMVRGVMKDYFDYWGQGTLVTVSS,AIQLTQSPSSLSASVGDRVTITCRASQDISSALVWYQQKPGKAPKLLIYDASSLESGVPSRFSGSESGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIK,AIQLTQSPSSLSASVGDRVTITCRAS--QDIS------SALVWYQQKPGKAPKLLIYD--------ASSLESGVPSRFSGSESG--TDFTLTISSLQPEDFATYYCQQFNS-----------------------YPLTFGGGTKVEIK-,QVQLVES-GGGVVQPGRSLRLSCAASG-FTFST-----YGMHWVRQAPGKGLEWVAVIWDD---GSYKYYGDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGITMVRG--------------VMKDYFDYWGQGTLVTVSS,IgG1,Kappa,0
GDPa1-245,zanolimumab,QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARVINWFDPWGQGTLVTVSS,DIQMTQSPSSVSASVGDRVTITCRASQDISSWLAWYQHKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPYTFGQGTKLEIK,DIQMTQSPSSVSASVGDRVTITCRAS--QDIS------SWLAWYQHKPGKAPKLLIYA--------ASSLQSGVPSRFSGSGSG--TDFTLTISSLQPEDFATYYCQQANS-----------------------FPYTFGQGTKLEIK-,QVQLQQW-GAGLLKPSETLSLTCAVYG-GSFSG-----YYWSWIRQPPGKGLEWIGEINH----SGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARVIN-----------------------WFDPWGQGTLVTVSS,IgG1,Kappa,3
GDPa1-246,zolbetuximab,QVQLQQPGAELVRPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPSDSYTNYNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYCTRSWRGNSFDYWGQGTTLTVSS,DIVMTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSYPFTFGSGTKLEIK,DIVMTQSPSSLTVTAGEKVTMSCKSS--QSLLNSGNQKNYLTWYQQKPGQPPKLLIYW--------ASTRESGVPDRFTGSGSG--TDFTLTISSVQAEDLAVYYCQNDYS-----------------------YPFTFGSGTKLEIK-,QVQLQQP-GAELVRPGASVKLSCKASG-YTFTS-----YWINWVKQRPGQGLEWIGNIYPS---DSYTNYNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYCTRSWRG---------------------NSFDYWGQGTTLTVSS,IgG1,Kappa,4