Under certain conditions, such as homogeneous population, sufficient subject number, sufficient sampling times and acceptable accuracy (CV<20%) for the concentrations, it is possible to get valuable and more reliable kinetic information by using concentrations obtained with a poor precision (CV>20%). This is especially true for the parameters associated with the terminal phase, such as t1/2 beta and AUC, but also for parameters depending to a lesser extent on the terminal phase, such as t1/2 alpha and AUCm