The reconstruction of complicated defects with 3-dimensional deficits remains challenging. The reconstruction of these defects requires not only coverage of surface but also appropriate obliteration of dead space, and muscle-chimeric perforator flaps can be a valuable option. Here, we present our experience with free latissimus dorsi (LD) muscle-chimeric thoracodorsal artery perforator (TDAP) flaps for the treatment of complicated defects.