This study was carried out on 60 patients and 24 sex- and age-matched healthy controls. Serum osteocalcin (OK) and bone specific alkaline phosphatase (BALP), which are bone formation markers and urine deoxipyridinolin (DOP) levels that is bone resorption marker were evaluated in patient and controls groups. Serum IL-1 and TNF-alpha levels were measured in both groups. BMD was measured with dual X-ray absorptiometry (DEXA) at the lumbar spine and left femur.