BMD (measured by osteo C.T. of the lumbar spine) and bone resorption (deoxypyridinoline) and formation (alkaline phosphatase bone isoenzyme) markers were measured in 40 female postmenopausal patients with NIDDM and in 40 non-diabetic females of the same age. The same investigations were carried out in 20 males with NIDDM and in 20 normal non-diabetic males.