. We compared GI and II values in non-diabetic subjects with fasting-serum-insulin (FSI)<40 pmol/l (healthy control) or with FSI ≥ 40 pmol/l (hyper[I]) and subjects with type 2 diabetes (T2DM), and to see whether GI and II were related to the serum-glucose concentrations, insulin sensitivity, β-cell function and hepatic insulin extraction (HIE) of the subjects.SUBJECTS/