Anti-hepatitis A virus antibodies, liver histopathology and alanine aminotransferase activity were determined in 82 patients with chronic hepatitis C. The liver biopsy specimen of each patient was examined according to Scheuer's classification to indicate the severity of the inflammatory cell infiltration in the portal/periportal and parenchymal area (grading) in a 0-4 scale and fibrous stage (staging) in a 0-4 scale.