In the first intraoperative frozen section analysis, 26 patients were positive for adenoma or borderline lesion, 10 for carcinoma in situ, 2 for cancer cells floating in the duct, and 6 for invasive cancer. Twenty-nine patients underwent additional resection, and 105 patients finally achieved a negative pancreatic margin. Among 18 patients with a positive pancreatic margin for adenoma or borderline lesion, only 1 had a recurrence