Administration of enalapril resulted in preserved UF (-0.2 +/- 0.7 mL vs 1.7 +/- 0.3 mL, p<0.05), protein loss (2.3 +/- 0.5 g/L vs 1.6 +/- 0.2 g/L, p>0.05), and peritoneal thickness (77 +/- 7 microns vs 38 +/- 5 microns, p<0.001). D/P urea increased significantly in the Dx group (p<0.05). Both higher levels of TGFbeta1 (undetectable vs 298 +/- 43 pg/mL, p<0.001) and lower levels of CA125 in dialysate effluent (0.94 +/- 0.5 U/L vs 0.11 +/- 0.1 U/L, p>0.05) were determined in the Dx group.