separately to the Securities and Exchange Commission. 18 IN WITNESS WHEREOF, the parties, each by its duly authorized signatory, have caused this Agreement to be executed as of the date first above- mentioned. /s/ Gal Cohen /s/ Ching-Kuan Lin MediWound Ltd. Challenge Bioproducts Corporation Ltd. By: Gal Cohen By: Ching-Kuan Lin Its: Chief Executive Officer Its: President MediWound Ltd. Challenge Bioproducts Co., Ltd. *** Confidential treatment has been requested for redacted portions of this exhibit. This copy omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete version of this exhibit has been provided separately to the Securities and Exchange Commission. 19 List of Exhibits Exhibit 1.13 - Current Bromelain SP Specifications Exhibit 4.2 - Price list per annual quantity Exhibit A - a copy of this Supply Agreement as originally signed on 11/1/2001 *** Confidential treatment has been requested for redacted portions of this exhibit. This copy omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete version of this exhibit has been provided separately to the Securities and Exchange Commission. 20 Exhibit 1.13 — Current Bromelain SP Specifications [***] *** Confidential treatment has been requested for redacted portions of this exhibit. This copy omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete version of this exhibit has been provided separately to the Securities and Exchange Commission. Exhibit 4.2 — Price list per annual quantity MediWound Ltd. 42 Hayarkon Street, Yavne, Israel Tel: 972-8-9324010 www.mediwound.com Supply Agreement as amended on Feb 28 2010. Exhibit 4.2 — Price list per annual quantity The price of [***]Kg of released BSP below an annual ordered quantity of [***] Kg shall be USD[***]/Kg [***]. The price of [***]Kg of released BSP above an annual ordered quantity of