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  license: bsd-3-clause
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  license: bsd-3-clause
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+ tags:
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+ - Confocal Fluorescence Microscopy
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+ - Image Super-resolution
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+ - Deep Learning
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+ - Benchmark
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+ ---
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+
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+ # [SR-CACO-2: A Dataset for Confocal Fluorescence Microscopy Image Super-Resolution](https://arxiv.org/pdf/xxxx.xxxxx.pdf)
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+
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+
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+ by **Soufiane Belharbi<sup>1</sup>, Mara KM Whitford<sup>2,3</sup>,
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+ Phuong Hoang<sup>2</sup>, Shakeeb Murtaza<sup>1</sup>, Luke McCaffrey<sup>2,3,4</sup> Eric Granger<sup>1</sup>**
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+
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+
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+ <sup>1</sup> LIVIA, Dept. of Systems Engineering, ETS Montreal, Canada
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+ <br/>
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+ <sup>2</sup> Goodman Cancer Institute, McGill University, Montreal, Canada
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+ <br/>
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+ <sup>3</sup> Dept. of Biochemistry, McGill University, Montreal, Canada
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+ <br/>
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+ <sup>4</sup> Gerald Bronfman Dept. of Oncology, McGill University, Montreal,
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+ Canada
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+
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+ <p align="center"><img src="patch-demo.png" alt="outline" width="80%"></p>
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+
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+ ## ArXiv: [2402.00281](https://arxiv.org/pdf/2402.00281.pdf)
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+
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+ ## Abstract
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+ Confocal fluorescence microscopy is one of the most accessible and widely used
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+ imaging techniques for the study of biological processes at the cellular and
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+ subcellular levels. Scanning confocal microscopy allows the capture of
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+ high-quality images from thick three-dimensional (3D) samples, yet suffers from
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+ well-known limitations such as photobleaching and phototoxicity of specimens
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+ caused by intense light exposure, which limits its use in some applications,
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+ especially for living cells. Cellular damage can be alleviated by changing
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+ imaging parameters to reduce light exposure, often at the expense of image
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+ quality. Machine/deep learning methods for single-image super-resolution (SISR)
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+ can be applied to restore image quality by upscaling lower-resolution (LR)
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+ images to produce high-resolution images (HR). These SISR methods have been
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+ successfully applied to photo-realistic images due partly to the abundance of
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+ publicly available data. In contrast, the lack of publicly available data
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+ partly limits their application and success in scanning confocal microscopy.
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+ In this paper, we introduce a large scanning confocal microscopy dataset named
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+ SR-CACO-2 that is comprised of low- and high-resolution image pairs marked for
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+ three different fluorescent markers. It allows the evaluation of performance of
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+ SISR methods on three different upscaling levels (X2, X4, X8). SR-CACO-2
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+ contains the human epithelial cell line Caco-2 (ATCC HTB-37), and it is
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+ composed of 22 tiles that have been translated in the form of 9,937 image
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+ patches for experiments with SISR methods. Given the new SR-CACO-2 dataset,
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+ we also provide benchmarking results for 15 state-of-the-art methods that are
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+ representative of the main SISR families. Results show that these methods have
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+ limited success in producing high-resolution textures, indicating that SR-CACO-2
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+ represents a challenging problem. Our dataset, code and pretrained weights are
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+ available: https://github.com/sbelharbi/sr-caco-2.
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+
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+ **Code: Pytorch 2.0.0**
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+
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+ ## Citation:
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+ ```
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+ @article{belharbi24-sr-caco-2,
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+ title={SR-CACO-2: A Dataset for Confocal Fluorescence Microscopy Image Super-Resolution},
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+ author={Belharbi, S. and Hoang, P. and Whitford, M. and Murtaza, M. and
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+ McCaffrey, L. and Granger, E.},
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+ journal={CoRR},
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+ volume={abs/xxxx.xxxxx},
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+ year={2024}
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+ }
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+ ```
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+
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+
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+
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+ ## <a name="weights"> Pretrained weights (evaluation) </a>:
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+ We provide the weights for all the models (135 models: 15 methods x 3 cells
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+ x 3 scales). Weights can be found at [Hugging Face](https://huggingface.co/sbelharbi/sr-caco-2) in the file [shared-trained-models.tar.gz](https://huggingface.co/sbelharbi/sr-caco-2/resolve/main/shared-trained-models.tar.gz?download=true).
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+
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+
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+ The provided weights can be used to reproduce the reported results in the
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+ paper in the paper:
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+ <p align="center"><img src="roi-perf.png" alt="roi performance"
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+ width="80%"></p>
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+ <p align="center"><img src="full-img-perf.png" alt="full image performance"
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+ width="80%"></p>
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+