Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: The crystal structure of Nsp9 (PDB ID: 6W4B) was downloaded from the protein data bank (PDB) of for (RCSB). The crystal structure of the protein was determined at 2. 95 Å resolution [16]. The ligands are first drawn in Chem16. 0, followed by MM2 minimization using Chem3D and saved as SDF files. Subsequently, the SDF files were converted PDB files for each ligand using GUI software. Both protein and the ligands were prepared for the molecular docking experiments using Auto(ADT) 1. 5. 6 [17]. In the protein preparation process, water molecules were deleted, polar hydrogen atoms and Kollmans charges were added. For ligands, Gasteiger charges were added, aromatic carbon and rotatable bonds were detected, torsion number was automatically set, and non-polar hydrogens were merged. Then, protein and ligand files were saved as PDBQT files. Druggable pockets of the protein was predicted using online CavityPlus platform ( Based on the predicted most druggable pockets, the grid boxes were determined using ADT software. The grid box for pocket 1 was centered at x = 39. 82, y = –19. 72 and z = 24. 30 with sizes of 22. 28, 22. 17 and 24. 69 Å. For the pocket 2, grid box was centered at x = 56. 88, y = –0. 77 and z = 23. 96 with the sizes of 25. 97, 26. 32 and 26. 86 Å. Finally, the prepared flexible ligands were docked against the fixed rigid 6W4B protein using in Windows command line window after preparing config files with necessary information (receptor, grid box coordinates, number of modes: 10, energy range: 8 and exhaustiveness: 16) [18]. Pymol version 2. 4. 1 and 2020 Client software were used for the visualization and protein-ligand interactions, respectively. analysis of the naphthoquinones incubated with chassis cells. Our previous research has revealed that supplement of different nutrients into the fermentation broth of engineered E. coli resulted into the biosynthesis of unexpected by-products [19], suggesting the enzymes of host microorganisms may modify the structures of final products.

Output: pass


Input: Claim: Teacher quality significantly impacts student academic achievement. [SEP] Text: 교사-학생관계의 변화가 중학생의 학업성취도 향상에 미치는영향 : 패널자료분석(panel data analysis)을 사용하여 교사교육연구 [Internet]. 2015; 54(1), : 59 - 73. Available from: doi:10. 15812/ter. 54. 1. 201503. 59 김근진 이현철. “교사-학생관계의 변화가 중학생의 학업성취도 향상에 미치는영향 : 패널자료분석(panel data analysis)을 사용하여“ 교사교육연구 54, no. 1, (2015): 59 - 73. doi: :10. 15812/ter. 54. 1. 201503. 59 텍스트 파일로 저장 피인용 논문 (우)305-754 대전광역시 유성구 가정로 201 한국연구재단 TEL: 042-869-6674, 1544-6118 E-mail: kciadmin@nrf. re. kr 2024 NRF. .

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Deepfake detection [11]: Generally, it refers to digital assets in the form of audio, image, or video (often containing people) where artificial intelligence techniques are used to change the content. Shallowfakes and cheapfakes are variations of the latter where either the techniques could be more efficient or when they are not based on artificial intelligence. However, the objective of the manipulation is the same. Artificial intelligence can also be used to detect such manipulations through training with examples. However, these techniques only work on transformed digital assets rather than the ones generated from scratch. 2. 2 TrendsWith the growing reliance on multimedia content in the daily lives of citizens, both professionally and in their private lives, media security is becoming an essential technology to include in many applications. The following presents some of the immediate challenges and trends: Privacy protection in pictures and video, particularly for video surveillance and social networks and especially in the context of GDPR [12]. Countermeasures to fight the growing use of deepfakes to spread misinformation. Media security standardization to create interoperable, secure ecosystems, particularly those developed by International Standardization Organizations such as JPEG [13]. 3 Consequences for SwitzerlandHistorically, Switzerland has been considered a country of stability, trust, and security. Several standard-setting organizations dealing with information and communication technologies, including those defining security mechanisms, are also based in Switzerland, and it is easier for Swiss actors in media security to play an essential role in the definition of media security standards that will be the backbone of information and communication technologies in the new world order. Furthermore, like any other country, Switzerland is also vulnerable to misinformation which can result in unrest and instability and hurt its so-far impeccable image. 3. 1 Implementation Possibilities: Make or BuyIt is only possible to decide abstractly and by knowing the precise application and context, if media security tools should be made, tailored, or bought from third parties. However, some guidelines can provide help to find the answer on a case-by-case basis: Proprietary and closed solutions in media security should be avoided. In a security context, it has been demonstrated multiple times that security tools and systems whose specifications are kept secret are weaker and more vulnerable to attacks when compared to open and publicly accessible specifications [14]. Media security tools and solutions based on international standards where multiple suppliers can be identified as providers of tools and solutions are mainly preferable.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Comparison of 1H NMR data of 9 with that of the substrate 1,4-naphthoquinone (Fig. S3 and S22) revealed 4 aromatic proton signals (δ 8. 00, 7. 94, 7. 84, and 7. 75) and a CH singlet (δ 5. 68) indicating the presence of naphthoquinone moiety and the substitution of one proton for quinone ring. The additional proton signals, including an overlapped signal corresponding to 2 carboxyl protons (δ 12. 67), NH doublet belonging to NH-1' (δ 7. 32), CH multiplet belonging to H-2' (δ 4. 05-4. 20), CH2 triplet belonging to H-5' (δ 2. 35) and CH2 quartet belonging to H-4' (δ 2. 09), established the presence of Glu residue based on the 1H -1H COSY correlations among NH-1', H-2', H-4' and H-5' (Fig. 3 and S24). Consistently, the 13C NMR spectrum of 9 exhibited signals attributable to a naphthoquinone, 2 carboxyl groups (δ 174. 54 and 172. 51), a methine group (δ 54. 73) and 2 methylene groups (δ 30. 63 and 26. 26) (Fig. S23). Although the carbon signal at δ 172. 51 was weak, we identified it through the heteronuclear multiple-bond correlation (HMBC) spectrum (Fig. S26). These findings suggested that Glu group was introduced to the quinone ring of 1,4-naphthoquinone at C-2. This was confirmed by the HMBC spectrum. As shown in Fig. 3, the HMBC correlations of NH-1' at δ 7. 32 to C-1, C-3, C-2', C-3' and C-4', H-2' at δ 4. 05-4. 20 to C-4', H-4' at δ 2. 09 to C-2', C-3', C-5' and C-6', and H-5' at δ 2.

Output: pass


Input: Claim: Video games negatively impact academic performance. [SEP] Text: 10 Issue 5 2023 2023 IJRSM – Vol. 11 Issue 1 IJRSP 2012 2012 IJRSP – Vol. 1 Issue 1 2012 IJRSP – Vol. 1 Issue 2 2012 IJRSP – Vol. 1 Issue 3 2013 2013 IJRSP – Vol. 2 Issue 1 2013 IJRSP – Vol. 2 Issue 2 2013 IJRSP – Vol. 2 Issue 3 2013 IJRSP – Vol. 2 Issue 4 2014 2014 IJRSP – Vol. 3 Issue 1 2014 IJRSP – Vol. 3 Issue 2 2014 IJRSP – Vol. 3 Issue 3 2014 IJRSP – Vol. 3 Issue 4 2014 IJRSP – Vol. 3 Issue 5 2015 2015 IJRSP – Vol. 4 Issue 1 2015 IJRSP – Vol. 4 Issue 2 2015 IJRSP – Vol. 4 Issue 3 2015 IJRSP – Vol. 4 Issue 4 2016 2016 IJRSP – Vol. 5 Issue 1 2016 IJRSP – Vol. 5 Issue 2 2016 IJRSP – Vol. 5 Issue 3 2016 IJRSP – Vol. 5 Issue 4 2017 2017 IJRSP – Vol. 6 Issue 1 2017 IJRSP – Vol. 6 Issue 2 2018 2018 IJRSP – Vol. 7 Issue 1 2018 IJRSP – Vol. 7 Issue 2 2019 2019 IJRSP – Vol. 8 Issue 1 2019 IJRSP – Vol. 8 Issue 2 Contact Mobile-games: Impact on the academic performance among hospitality management students in University 2023 IJRSE – Available Online: 15 March 2023 Author/s: Marcelo, Jefferson* University, Philippines (Jeffersonmarcelo119@gmail. com) : Online gaming can negatively impact students’ academic performance. Playing mobile games should be a fun activity for all to enjoy. But like everything else, the amount of time one spends playing needs to be balanced with academic responsibility. Furthermore, this study sought answers on number of hours spent in mobile games, commonly played online mobile games, the attitude of respondents on playing mobile games, and the reasons for playing mobile games, and find out the impact of mobile games to the academic performance among hospitality management students. The researchers collected, analyzed, and interpreted the data using a descriptive design approach and a quantitative form of survey questionnaire distributed to University’s students.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: In mission-sensitive contexts, including in applications relevant to national security, design, and validation, in particular, the security analysis of tools and solutions should be performed internally and externally by relying on trusted third parties. 3. 2 Variations and RecommendationMedia security is no longer a niche; many applications need media security tools and solutions in addition to more general security tools and solutions such as symmetric or asymmetric encryption. Therefore, Switzerland needs to strengthen its skills and know-how in media security through initiatives to encourage education and public-private collaborations. In most cases, media security tools and solutions can result in successful business opportunities for those involved. 4 ConclusionMedia security refers to a large spectrum of tools and solutions that often need to be sufficiently and optimally addressed through generic information security tools and solutions. At the same time, media security tools and solutions are increasingly essential elements in many professional and private applications that have become multimedia-rich. Breach of security in applications where multimedia information is used can have devastating and irreversible consequences. This can go from impact on the privacy of citizens to manipulation of public opinion through misinformation, which is particularly dangerous in the Swiss context where direct democracy is a foundational principle, requiring well-informed citizens who need to depend on reliable information. Because of these reasons, media security must have a prominent position in the Swiss strategy in cybersecurity in the years to come.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: 35 to C-2', C-4' and C-6' confirmed the connection of the Glu group with 1,4-naphthoquinone at C-2. Thus, compound 9 was identified as (1,4-dioxo-1,4-dihydronaphthalen-2-yl)glutamic acid. The assigned carbon and proton signals are listed in Table 2. Fig. 3. Selected 1H-1H COSY and HMBC correlations for 9–12, 16 and 17. Full size imageCompound 10 was isolated as a purple powder with determined the molecular formula as C15H12N2O5S according to its data [M + H]+, m/z 333. 0542. This was 57 mass units larger than compound 6, which possessed identical UV-vis spectra with it (Fig. S1). Similar to that of 6, the 1H NMR and 1H -1H COSY spectra of 10 (Fig. S13, S15, S27 and S29) also showed the presence of a naphthoquinone core (δ 7. 98, 7. 90, 7. 78, and 7. 73) and Cys moiety bridging C-2 and C-3 of the quinone ring (δ 7. 93, 4. 54, 2. 79, and 3. 23), excepting 3 additional proton signals, including NH triplet at δ 8. 08 and 2 vicinal CH doublet of doublets at δ 3. 55 and δ 3. 78, respectively. Besides, 2 additional carbon signals were found in the 13C NMR spectrum, δ 42. 04 and 171. 41 (Fig. S14 and S28). According to the heteronuclear single quantum coherence (HSQC) spectrum, both of the two CH protons (δ 3. 55 and 3. 78) were directly attached to the carbon at δ 42. 04 (Fig. S30). All of these data suggested that 10 was a derivative of 6 and may contain an additional Gly residue connected to the Cys via an amide bond. It was confirmed by the HMBC correlations shown in Fig. 3. The HMBC correlations of NH-1' at δ 7.

Output: pass


Input: Claim: The Renaissance influenced art, science, and thought across Europe. [SEP] Text: theory and practice of proffering consolation commanded a prominent place in humanist moral thought and literature. Reviving and furthering the tradition of the ancient consolatio, Renaissance writers formulated solace for such problems as bereavement, the fear of death, illness, despair, and misfortune. In the Trecento and Quattrocento there appeared many consolatory letters and funeral orations as well as numerous consolatory dialogues and treatises. The coherence and importance of this consolatory tradition in Renaissance culture have not been fully recognized. By studying this tradition more closely we can learn much about the psychological functions of rhetoric and philosophy in Renaissance thought. Equally important, we can begin to see more clearly how the history of ideas has sometimes been changed and enriched by its quiet counterpart, the “history of emotions. ” 10. 2307/2862039 [Opens in a new window] © of America 1986 Access options Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access. ) 11. bis zum 16. Jahrhundert, Beiträge zur Geschichte der Philosophic und Theologie des 1-2 (Münster, 1928); B. Langston, “of Consolation,” Diss. University of North Carolina, 1940. For more recent scholarship see Diekstra, F. N. M. , “Introduction,” in his A Reason and Adversity: A of Petrarch's De remediis (Assen, 1968), 1981. I would like to thank for reading the above manuscript, from which much of this present 968. 3 3 As for the general literary tradition concerning the loss of a son, see Quintilian's discussion of the death of his son in the Prooemium to Book VI of his Institutiones oratoriae. In the thirteenth century Vincent of Beauvais wrote a lengthy Tractatus consolatorius ad Ludovkum IX regem de ohitu filii. The loss of sons was a category in Boncompagno da Signa's discussion of consolation in his antiqua. I, 284. For other Renaissance writings on the loss of sons see Banker, 361.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: �α παραχωρούν τα προσωπικά τους δεδομένα σε εταιρείες και φορείς, χωρίς να γνωρίζουν πώς αυτά θα χρησιμοποιηθούν στην συνέχεια.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: 93 to C-1, C-3, C-2' and C-4', H-2' at δ 4. 54 to C-2, C-3' and C-4', and H-4' at δ 2. 79 and 3. 23 to C-3, C-2' and C-3' confirmed the connection of the Cys residue group with 1,4-naphthoquinone at C-2 and C-3. The linkage of Gly residue to Cys group and the peptide bond were determined based on the HMBC correlations of NH-5' at δ 8. 08 to C-3' and C-6', and H-6' at δ 3. 55 and 3. 78 to C-3' and C-7'. Therefore, 10 was identified as (5,10-dioxo-3,4,5,10-tetrahydro-2H-naphtho[2,3-b] [1, 4]thiazine-3-carbonyl)glycine. All the carbon and proton signals were assigned and are listed in Table 2. Compound 11 was isolated as an orange powder, exhibiting the molecular formula C25H22N2O4 as established by ([M + H]+, m/z 415. 1659). It was clearly a symmetric structure as judged by its 1H and 13C NMR spectra (Fig. S32 and S33), which showed 11 protons and 13 carbons. In the 1H NMR spectrum, 4 aromatic proton signals (δ 8. 10, 8. 04, 7. 73, and 7. 62), a NH multiplet (δ 5. 86–5. 93) and a CH singlet (δ 5. 73) observed in the low field showed the presence of a naphthoquinone core and the substitution of H-2 by an amino group. Consistently, the 13C NMR spectrum revealed that there were 2 ketone groups (δ 182. 99 and 181. 90), suggesting that the naphthoquinone moiety is still present. Three additional aliphatic proton signals were found in the high field (δ 3. 23, 1. 77, and 1. 48–1.

Output: pass


Input: Claim: The Silk Road facilitated cultural exchange between East and West. [SEP] Text: 북위시대를 거쳐 이후에 축조된 왕성에서 이와 같은 형태를 찾아볼 수 없다는 점은 북위시대 불교문화형성이 다른 지역의 것이 이식된 사실 즉, 실크로드와의 끊임없는 교류를 통해 직접적인 연관성을 지닌다는 것으로 풀이될 수 있다. 또한 실크로드를 비롯한 동아시아에서의 불교와 민간신앙과의 습합이 왕성 축조에도 영향을 미쳤다는 점을 볼 수 있다. The ancient oasis nations located at the dessert area of the southern route of the Silk Road, the era of the Southern and of China and the era of the of Korea had Buddhism, which spread rapidly and developed, as a common point. The construction of King’s castle was another precondition for the foundation and existence of a nation with the religion.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η ψηφιοποίηση πολλών δραστηριοτήτων της καθημερινότητας του σύγχρονου ατόμου, οι αυξημένες δυνατότητες αποθήκευσης μεγάλου όγκου δεδομένων και τα ισχυρά μέσα επεξεργασίας που υπάρχουν διαθέσιμα σήμερα, καθιστούν τη διαρροή προσωπικών δεδομένων σημαντική απειλή για την ασφάλεια και την ευημερία των πολιτών.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: 59), which belonged to H-2', H-3' and H-4'. The 1H-1H COSY spectrum confirmed the connections among them, and between NH-1' and H‑2' (Fig. 3). The position of the aliphatic chain was determined by the HMBC correlation of NH-1' to C-1, C-3 and C-2', and H-2' to C-2 (Fig. 3). Thus, the structure of compound 11 was elucidated as 2,2'-(pentane-1,5-diylbis(azanediyl))bis(naphthalene-1,4-dione). The assigned carbon and proton signals are listed in Table 2. Compound 12 was obtained as a purple powder, and its molecular formula was determined to be C13H9NO5S by which gave a m/z 292. 0276 for [M + H]+. The 1H NMR spectrum showed 3 aromatic protons (δ 7. 58, 7. 51, and 7. 25) and a chelating phenolic hydroxyl group (δ 12. 61), while the 13C NMR spectrum exhibited 2 ketone groups (δ 184. 20 and 177. 39) and an aromatic quaternary carbon signal belonged to C-5 at δ 160. 61 (Fig. S37 and S38). They established the 5-hydroxy-1,4-naphthoquinone core of 12 by a comparison of the NMR data with the substrate juglone (Fig. S4), [20] and it was further supported by the HMBC correlations shown in Fig. 3. The other additional proton signals were similar to those of 6 and 10, including a broad singlet at δ 8. 08 belonged to NH-1', a CH multiplet at δ 4. 44-4. 61 belonged to H-2', and 2 vicinal CH doublet of doublets both belonged to H-4' (δ 3. 18 and 3. 05). The 1H-1H COSY correlations among them were shown in Fig. 3. Besides, similar to the 1H NMR spectrum of 6 and 10, no signal for H-2 or H-3 was found.

Output: pass


Input: Claim: The Silk Road facilitated cultural exchange between East and West. [SEP] Text: On the Silk Road, which had been the route of Buddhist spread to the East, the construction of the king’s castle was done in a very narrow space due to local geographic characteristics,and it seemed Buddhist temples were placed inside the castles naturally as it was recognized as the national religion. The remains of ancient tomb land are found in the northernmost of the ancient castles while it has been identified that the Buddhist pagodas and temples were formed in adjacent southern region. The relation between the tomb lands and the Buddhist pagodas cannot be confirmed using only these two cases, however it is possible to interpret that the ideas of death and the afterlife were accepted in religious perspectives when constructing the ancient kings’ castles. The locations of Buddhist temples had been identified to have relationship not only with the tomb lands but also with the king’s castle. The temples were built on the northwest of the castles. The tombs, Buddhist structures and the king’s castle were built in order from the north. This may imply that there had been relationship established between the afterlife and Buddhism. Also the royal family had connections with the religion for its and nation’s prosperities. The style of the king’s castle was also affected by the religious idea about the present and the future. In this way, it was identified that the way to construct the castle as revealed along the had a direct impact on the era of the Southern and of China, in particular, the so that the locations of intra-castle temples after moving the capital to were mostly concentrated to the northwestward direction of the palace. Considering the fact that such characteristics could be found in the castles built after the Northern Wei, the cultures from other regions must have been spread into the Northern Wei’s Buddhist culture. This means that the ceaseless cultural exchange through the had affected the construct of the king’s castle in many ways. Moreover, not only the culture from the but Buddhism and folklore impacted the building of king’s castles.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η έλλειψη προστασίας της ιδιωτικότητας και οι αρνητικές συνέπειες που προκύπτουν από την καταχρηστική εκμετάλλευση των προσωπικών δεδομένων, απασχολεί όλο και περισσότερο τους σύγχρονους πολίτες, οι οποίοι νιώθουν ανίκανοι να ελέγξουν πού διακινούνται και με ποιόν τρόπο χρησιμοποιούνται τα προσωπικά τους δεδομένα. Το γεγονός αυτό έχε. .

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Those indicated that there was Cys moiety bridging C-2 and C-3 of the quinone ring. It was obvious that 12 was an additional product of Cys to juglone. The position of the Cys moiety was determined by the HMBC correlation of NH-1' to C-1, and H-4' to C-3 (Fig. 3). Thus, 12 was identified as 9-hydroxy-5,10-dioxo-3,4,5,10-tetrahydro-2H-naphtho[2,3-b] [1, 4]thiazine-3-carboxylic acid. All the carbon and proton signals were assigned and listed in Table 2. Biosynthesis of naphthoquinone derivatives supplemented with amino acids. Analyzing the structures of 1–15, most of the products seem to be the direct additions of amino acids to naphthoquinones. To confirm this, we added L-Glu into the fermentation broth of S. cerevisiae INVSc1 with supplemented 1,4-naphthoquinone to observe whether the yield of 9 increased. As a result, the content of 9 significantly increased, but we also detected it in substrate control (Fig. 4a). These suggested that these compounds were the additional products of amino acids with naphthoquinones. However, this fact alone was not enough to explain the formation of compound 6, 7, 10, 11, 12, 14 and 15. Among these compounds, 6, 10 and 12 had similar structures and 6 was the simplest one. The directed biosynthesis of 6 was carried out to explore the form of the dihydro-thiazine ring in their structure. Therefore, L-Cys was fed into the fermentation broth of S. cerevisiae INVSc1 with supplemented 1,4-naphthoquinone. After 7 days, the cultures were extracted and subjected to HPLC analysis. As shown in Fig. 4b, the production of 6 significantly increased as expected, compared to the fermentation broth without L-Cys (trace i and ii). However, 6 was also detected in substrate control (trace iii). This result explained the formation of dihydro-thiazine ring in 6, 10 and 12.

Output: pass


Input: Claim: The Silk Road facilitated cultural exchange between East and West. [SEP] Text: 북위시대를 거쳐 이후에 축조된 왕성에서 이와 같은 형태를 찾아볼 수 없다는 점은 북위시대 불교문화형성이 다른 지역의 것이 이식된 사실 즉, 실크로드와의 끊임없는 교류를 통해 직접적인 연관성을 지닌다는 것으로 풀이될 수 있다. 또한 실크로드를 비롯한 동아시아에서의 불교와 민간신앙과의 습합이 왕성 축조에도 영향을 미쳤다는 점을 볼 수 있다. KW - 실크로드, 호탄, 왕성, 비사문천, 니야, 누란 DO - 10. 21482/jbs. 33. . 201212. 199 UR - ER - 한지연 (2012).

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Ο τρόπος που διεξάγονται οι ηλεκτρονικές συναλλαγές σήμερα αναγκάζει τους πολίτες να παραχωρούν τα προσωπικά τους δεδομένα σε εταιρείες και φορείς, χωρίς να γνωρίζουν πώς αυτά θα χρησιμοποιηθούν στην συνέχεια. Περιστατικά σκόπιμης ή μη διαρροής προσωπικών δεδομένων έρχονται στο φως της δημοσιότητας καθημερινά, προκαλώντας την έντονη ανησυχία των πολιτών.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Compounds 7, 14 and 15 may be the decarboxylation products after Ser molecule attached to 1,4-naphthoquinone or juglone. Considering 7 is the simplest compound among them and produced both by S. cerevisiae INVSc1 and E. coli BL21(DE3), we next tested whether supplement of L-Ser in the fermentation broth with 1,4-naphthoquinone can increase the production of 7. Meanwhile, 11 is most likely biosynthesized by decarboxylation after Lys attached to two 1,4-naphthoquinones, so we also added L-Lys monohydrochloride into the fermentation broth of E. coli BL21(DE3) with supplemented 1,4-naphthoquinone to confirm this. The experiments were carried out for 7 days and the results were shown in Figs. 4c–4e. Unexpectedly, the productions of 7 and 11 not significantly increased as that of 6. Instead, 2 additional products, 16 and 17, were produced in significant amount. Besides, we also detected them in substrate control. Thus, 16 and 17 might be Ser and Lys attached to 1,4-naphthoquinone on the C-2 position, respectively. To confirm this, we purified them for structural characterization. Fig. 4. HPLC (336 nm) analysis after incubation of 1,4-naphthoquinone and Glu, Cys or Ser with chassis cells. (a): i—S. cerevisiae INVSc1 + 1,4-naphthoquinone; ii—S. cerevisiae INVSc1 + 1,4-naphthoquinone + Glu; iii—1,4-naphthoquinone + Glu. (b): i—S. cerevisiae INVSc1 + 1,4-naphthoquinone; ii—S. cerevisiae INVSc1 + 1,4-naphthoquinone + Cys; iii—1,4-naphthoquinone + Cys. (c): i—S. cerevisiae INVSc1 + 1,4-naphthoquinone; ii—S.

Output: pass


Input: Claim: World War II significantly reshaped global politics and alliances. [SEP] Text: [단행본] 테일러, A. J. P. / 2003 제2차 세계대전의 기원 지식의 풍경 18. [단행본] 파슨스, 티머시 2012 제국의 지배: 제국은 왜 항상 몰락하는가 까치 19. [단행본] 파월, 자크 2017 좋은 전쟁이라는 신화: 미국의 제2차 세계대전, 전쟁의 추악한 진실 오월의봄 20. [단행본] 히틀러, 아돌프 2014 나의 투쟁 동서문화사 21. [단행본] Black, Jeremy 2015 War Two: and its Legacy Bloomsbury 22. [단행본] Bosworth, Richard 2015 History of the War Vol. I: Fighting the War Press 23. [단행본] Diefendorf, Jeffrey M. / 2004 Lessons and Legacies VI: in Press 24. [단행본] Dower, John 1986 War without Mercy: Race and the Power in the W. W. Norton & Company 25. [단행본] Earle, Edward 1943 Makers of Modern Strategy: from Machiavelli to Hitler Press 26.

Output: pass


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η ψηφιοποίηση πολλών δραστηριοτήτων της καθημερινότητας του σύγχρονου ατόμου, οι αυξημένες δυνατότητες αποθήκευσης μεγάλου όγκου δεδομένων και τα ισχυρά μέσα επεξεργασίας που υπάρχουν διαθέσιμα σήμερα, καθιστούν τη διαρροή προσωπικών δεδομένων σημαντική απειλή για την ασφάλεια και την ευημερία των πολιτών.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: cerevisiae INVSc1 + 1,4-naphthoquinone + Ser; iii—1,4-naphthoquinone + Ser. (d): i—E. coli BL21(DE3) + 1,4-naphthoquinone; ii—E. coli BL21(DE3) + 1,4-naphthoquinone + Ser; iii—1,4-naphthoquinone + Ser. (e): i—E. coli BL21(DE3) + 1,4-naphthoquinone; ii—E. coli BL21(DE3) + 1,4-naphthoquinone + Lys; iii—1,4-naphthoquinone + Lys. Samples were analyzed using linear gradient of 10–90% (vol/vol) acetonitrile-water (containing 0. 1% formic acid) for 30 min at a flow rate of 1 mL/min. Full size imageStructural characterization of 16 and 17. Compound 16 was isolated as an orange powder, exhibiting the molecular formula C13H11NO5 as established by [M + H]+, m/z 262. 0711, which is one CHO2 unit longer than 7. Consistently, the 13C NMR spectrum of 16 revealed that there was an additional carboxyl carbon signal at δ 171. 44 (Fig. S47). These indicated that 16 may be Ser attached to 1,4-naphthoquinone on the C-2 positions. The 1H NMR spectrum of 16 showed several proton signals in the low field, including 4 aromatic proton signals (δ 8. 03, 7. 95, 7. 85, and 7. 76), NH doublet (δ 6. 98) and CH singlet (δ 5. 74) (Fig. S46), which indicated the presence of a naphthoquinone moiety with NH at C-2. CH multiplet at δ 4. 18–4. 26 and CH2 doublet at δ 3. 83 that belong to H-2' and H-4′ were observed in the high field. The 1H-1H COSY spectrum confirmed the connectivities among them and NH-1' (Fig. 3).

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: . . . . . . . . . . ٠ kt a/k 898 ٠٠ 45 45. . . . . . . . . . . . . . 1/1 kt a/k 898 wardum 45 shekels of silver 90 shekels of silver 1/2 (if wardum pays his price) 110. 11 child 33 shekels of silver 45 " "" 1/1,35 kt v/k 125 family - 60 " The texts contain interesting information institution of slavery which we summarize. on slave sales and the Conditions for regaining freedom In kt a/k 898 (Sever, no. 2) Istar-baSti bought Sikuwa for 45 shekels of silver from Subili, son of Hanuwa. If the creditor or somebody else claims Sikuwa back, he shall pay the original purchase price. If the slave himself wants to become free, he has to pay its double, 90 shekels. In kt v/k 65 (Sever, no. 7) the native Inar, sold for 37,5 shekels of silver, can redeeme himself by paying the same amount. In kt v/k 125 (Sever, no. 8), where the native woman Labarsa sold Subianika and her daughter to an Assyrian, ASSur-bel-awatim, for an unstated amount those sold, have to pay Labarsa 1 mina of silver if they raise a claim in order become to free. Other examples are Kienast, nos. 11 and 12. Conditional sales In kt v/k 65, it is stated that the child Inar was sold for the price of 37. 5 shekels of silver by his elder brother, Ha؛ui and his mother, Kudida under the condition that if he did not behave well in the house of Tarmana who had bought him, he would be taken back at the same price or otherwise would say as a chattel slave of Tarmana. In kt a/k 933 (Sever, no. 3), it is stated that Etar-malak was sold to Enlil-bani by Imdilum for 1 mina of refined silver for two years.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η έλλειψη προστασίας της ιδιωτικότητας και οι αρνητικές συνέπειες που προκύπτουν από την καταχρηστική εκμετάλλευση των προσωπικών δεδομένων, απασχολεί όλο και περισσότερο τους σύγχρονους πολίτες, οι οποίοι νιώθουν ανίκανοι να ελέγξουν πού διακινούνται και με ποιόν τρόπο χρησιμοποιούνται τα προσωπικά τους δεδομένα.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Only one proton signal for H-2' was found, suggesting the substitution of a proton by a carboxyl group at this position, which was determined by the HMBC correlation of NH-1' to C-1, C-3 and C-3' (Fig. 3). Thus, the structure of 16 was elucidated as 2-(1,4-dioxo-1,4-dihydronaphthalen-2-ylamino)-3-hydroxypropanoic acid. All the carbon and proton signals were assigned and are listed in Table 2. Compound 17 was obtained as a red powder, determined the molecular formula as C26H22N2O6 according to its data ([M + H]+, m/z 459. 1561, calculated for C26H23N2O6, 459. 1556). 17 is one CHO2 unit longer than 11, suggesting that it may a derivative of 11 and contain a carboxyl group. Analysis of the 1H NMR spectrum showed a carboxyl proton signal (δ 13. 15), 8 aromatic proton signals (δ 8. 00 – 7. 88, 7. 82, and 7. 71), 2 NH proton signals (δ 7. 56 and 7. 25) and 2 CH singlets (δ 5. 69 and 5. 67) in the low field (Fig. S51), indicating the presence of a carboxyl group and 2 amino naphthoquinone moieties. In the high field of 1H NMR spectrum, a methine multiplet (δ 4. 11–4. 19) and 4 methylene groups (δ 3. 19, 1. 96, 1. 63 and 1. 42) that belong to H-2', H-7', H-4', H-6' and H-5' were observed. The 1H -1H COSY correlations among them and 2 NH groups were shown in Fig. 3, suggesting that a long side chain is connected to 2 naphthoquinones via 2 NH groups. Consistently, the 13C NMR and HSQC spectra of 17 exhibited signals attributable to 2 naphthoquinone moieties, a carboxyl group (δ 173. 04), a methine carbon (δ 55.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: At the end of this period Enlil-bani would pay back the same amount to Imdilum in order to get his slave back, otherwise the slave become Imdilum's property. Kienast, no. 37 is another example of a conditional sale. Slaves taken as pledges There are many examples of the taking of male or female slaves or senants as pledges for debts. For example, in kt 88/k 306, which is a legal document concerning a conflict bet١veen two Ass١٦ ians, it is recorded that as security for his unstated claim Su-Suen took from his debtor, A5Sur-nada his two donkeys, a female slave and a servant as pledges. It is also stated that Su- Suen would take these in case he suffered damage. Kt a/k 1163 records that for the 43 shekels of refined silver which Ela gave to Ili-emuqi as be'ulatum in Ashur, Umrm-tabat, the female slave of the latter, was taken as a pledge. In kt a/k 1224 it is recorded that since Usur-؛a-A5؛ur has a claim of 36 shekels of refined silver on Ennam-ili, Ili-iddin was taken as pledge. When the debtor pays the money, the slave will be returned. Other published examples of taking slaves as pledges are Kienast p. 93, 3 fig and p. 99, 2 y. Slaves as part of be'ulatum Our text no. 5 records that among the goods belonging to Basa, the daughter of Idna-AAsur, given to Adad-rabi, the son of Kikazu, as be'ulatum[4], also a slave girl figures. It is for the first time that a slave is part of a be'ulatum. Sale of one of its members by a family There are some documents indicating that, presumably because of financial problems, families had to sell some of its members. In our text no. l 1 the native child IlaliSkan was sold to Tep٠ala for 33 shekels of silver by his mother Wanialka and by Kanakana, daughter of Sezur, whose relation to IlaliSkan is unknown.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Για τους παραπάνω λόγους, καθίσταται κρίσιμη η ανάπτυξη σύγχρονων συστημάτων προστασίας της ιδιωτικότητας, τα οποία θα ενισχύουν την σωστότερη και αποδοτικότερη αξιοποίηση των προσωπικών δεδομένων, μειώνοντας τις πιθανότητες διαρροής και των κινδύνων που αυτή ενέχει. Η οικονομική διάσταση της ιδιωτικότητας (Economics of Privacy) αποτελεί ένα σύγχρονο και ιδιαίτερα επίκαιρο αντικείμενο έρευνας.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: 13) and 4 methylene groups (δ 42. 06, 30. 40, 27. 25, and 23. 31) (Fig. S52 and S54). The carboxyl group was located at C-3′ based on the HMBC correlations of NH-1', H-2' and H-4' to C-3'. The linkages of the long side chain to 2 naphthoquinones were determined based on the HMBC correlations of NH-1' at δ 7. 25 to C-1, C-3, C-2', C-3' and C-4', H-2' at δ 4. 11 – 4. 19 to C-2, H-7' at δ 3. 19 to C-12, and NH-8' at δ 7. 56 to C-11, C-13, C-6' and C-7' (Fig. 3). Therefore, 17 was identified as 2,6-bis(1,4-dioxo-1,4-dihydronaphthalen-2-ylamino)hexanoic acid. The assigned carbon and proton signals are listed in Table 2. Biosynthesis of amino sidechains for novel naphthoquinones derivatives. In order to confirm that 10 was biosynthesized from 6 and Gly, 7 was the decarboxylation product of 16, and 11 was the decarboxylation product of 17, we added the products as substrates into the fermentation broths of microorganisms. Since 10 was a derivative of 6 that contains an additional Gly residue connected to the Cys via an amide bond, 6 and Gly were fed into the fermentation broth of S. cerevisiae INVSc1 to produce 10. However, the peak for 10 was undetectable (Fig. 5a, iii). Compound 7 can be detected in both fermentation broths of S. cerevisiae INVSc1 and E. coli BL21(DE3), thus, we added 16 into these fermentation broths. The result was shown in Figs. 5b, 5c. As a result, 7 was produced, but the production was low. This result indicated that 7 was indeed converted from 16, but the low titer suggested that 7 might be mainly produced through other pathways.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: ta-as-a-am su-ma ma-ma-na-a a-na am-tim[10]û ma-ri-äa[11]i-tù-wa-ar 2/3 ma-na 5 GIN KU. 15. a-na Ab-sa-1 im ur؛-٩al IGI E-na-A-a؛-i DUMU Dan-i-li IGI Me-ra-li <DUMU> En-um-A-sur ٦Nuh(u)satum gave his female slave Kurubana, <the slave> of Nuh(u)؛atum, Nuh(u)satum sold (her). 6And (Mrs. ) Ab-sallim paid 45 shekels of silver, and Ab-sallim bought the female slave Kurubana and her child. 12If anyone claims the female slave and her child, he shall pay 45 shekels of silver to Ab-؛allim. 16Before Ennam-Assur, son of Dan-ili, before Merali, <son of> Ennum-Assur. L. 1,3,4: Nu-hu-sa-tum must be the name of a male person according to the text. But Nu-uh-Sa-tim in BIN 6,104:2 is female. The name must be derived from nuhsu: p. 320b; AHw p. 801b. L. 2,9: Ku-ru-ba-na could be an Akkadian name and be analysed as Kurub-Anna, but it may as well be native. L. 10,13: The word mer'um,"son", rarely occurs as mar'um in Old Assyrian. L. 12: mammana is a variant of mamman"somebody, anybody", cf. CAD M I p. 200b; AHw p. 601a. No. 2: kt 88/k 990 This is a document about the sale of a native woman by Peruwa to the wife of an Assyrian. Whoever (re)claims the slave girl shall pay the fourfold of the purchase price to the new owner. Obv. 1. 1 ma-na KU.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η επεξεργασία προσωπικών δεδομένων επιφέρει σημαντικά κέρδη στην αγορά σήμερα, αλλά ταυτόχρονα κρύβει σημαντικούς κινδύνους για την ιδιωτικότητα των πολιτών, με σημαντικά κόστη, σχετικά τόσο με την ασφάλεια όσο και με την οικονομία. Ταυτόχρονα, ο πολίτης δεν λαμβάνει κανένα μέρος από τα κέρδη των εταιρειών από την εκμετάλλευση των προσωπικών του δεδομένων.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: In addition, we also observed 1 in the blank control of 16, suggesting that 1 may be the degradation product of these amino acid naphthoquinones. Compound 11 similarly seemed to be biosynthesized by the decarboxylation of 17, and next we tested the biotransformation of 17 by E. coli BL21(DE3). As shown in Fig. 5d, no peak for 11 was detected, indicating that 11 was not the decarboxylation product of 17. Fig. 5. HPLC analysis after incubation of 1,4-naphthoquinone derivatives and Gly with chassis cells. (a; 524 nm): i—6 + Gly as the blank control; ii—10 in pure form; iii - S. cerevisiae INVSc1 + 6 + Gly. (b; 457 nm): i—16 as the blank control; ii—7 in pure form; iii—S. cerevisiae INVSc1 + 16. (c; 457 nm): i—16 as the blank control; ii—7 in pure form; iii—E. coli BL21(DE3) + 16. (d; 456 nm): i—17 as the blank control; ii—11 in pure form; iii—E. coli BL21(DE3) + 17. Samples were analyzed using linear gradient of 10–90% (vol/vol) acetonitrile-water (containing 0. 1% formic acid) for 30 min at a flow rate of 1 mL/min. Full size imageProposed biosynthetic pathway for the biosynthesis of naphthoquinone derivatives. In this work, we studied the modification of 1,4-naphthoquinone and juglone with the metabolites generated by S. cerevisiae or E. coli chassis cells. Seventeen products, including 6 novel compounds, were identified. As demonstrated in Fig. 7, we proposed the synthetic pathways for products 1–17. Some compounds, including 2–5, 8 and 9, were derived from naphthoquinones and contained an amino acid residue connected to C-2 of the quinone ring. 2 was formed from Val, 3 from β-Ala, 4 from γ-aminobutyric acid, 5 from Ala, 8 from Gly and 9 from Glu.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: si-i[m] Za-pi-za-pi A-na-na a-sa-at E-na-ah-is-ti Pe-ru-wa 5. GAL re-i-im DUMU Ta-pu-sa ta-as-a-am-؛i lu Pè-ru-wa E. 10. lu ma-ma-an Re١٦ a-na Zi-pi-zi-pi i-tu-wa-ar 4 ma-na KÙ. <a-na> L. E. 15. A-na-na i-sa-qal 11 niina of silver is the price of Zapizapi, Anana the wife of Enah-ili bought her (for it) from Peruwa, the chief of the shepherds, the son of Tapusa. 8If anyone, either Peruwa or anybody else, reclaims Zipizipi he shall pay 4 minas of silver <to> Anana. 15? L. 2,11: The text makes it clear that Zapizapi and Zipizipi refer to the same person. One might compare Zi-BE-zi-BE, the wife of Assur-amaram, daughter of AAsur-beli in EL no. 276. L. 2,14: The name Anana occurs also in BIN 4,165:1,2,3; Liv. 8:14; CCT 5,216:6 and AKT 1,76:2 (tablet), 8 (case) as the wife of Idi-Adad. L. 15: There are traces of erased writing on the reverse, but they offer no clue for the interpretation of this line. Nr. 3: kt n/k 1772 This document refers to the sale of a slave-girl belonging to an Assyrian household. It is a kind of quittance stating that a third person, Idi-Assur, has received the sale price in Kanis in the name of a daughter of the previous owner and seller, from the buyer, Kura. She hence promises not to raise any future claims. Obv. 5. -kà-nim DUMU Su-Sti-en،؛ sa 1/3 ma-na KÙ.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Η παρούσα διδακτορική έρευνα περιλαμβάνει τη διερεύνηση των τρόπων αξιοποίησης και προστασίας προσωπικών δεδομένων προς όφελος των κατόχων τους, προσφέροντάς τους τον έλεγχο της διακίνησης των προσωπικών τους πληροφοριών, καθώς και οφέλη από την χρήση τους στις συναλλαγές τους.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: It was confirmed that compound 9 was generated by the incubation of Glu with 1,4-naphthoquinone. Compounds 6, 10 and 12 share a similar structure, which have Cys moiety bridging C-2 and C-3 of the quinone ring through the amino and sulfhydryl groups to form a dihydro-thiazine ring. The incubation of 6 with Gly did not give 10, yet it was proposed that 10 was derived from the Cys-Gly dipeptide attached to 1,4-naphthoquinone on C-2 position because Cys-Gly dipeptide is generated from the glutathione S-transferase degradation pathway endogenous in S. cerevisiae [21]. Ethanolamine can be generated from the decarboxylation of Ser [22]. Compound 7 is derived from the attachment of ethanolamine to the C-2 position of 1,4-naphthoquinone, whereas 14 and 15 were generated by the attachment of ethanolamine to the C-2 or C-3 position of juglone. The incubation of Ser with 1,4-naphthoquinone gave 16, which was further decarboxylated into 7 by both S. cerevisiae INVSc1 and E. coli BL21(DE3) chassis cells. 16 was nonenzymatically converted to 1, suggesting that 13 was also the degradation product of juglone derivatives, such as 14 or 15. Compound 17 was generated by 2 units of 1,4-naphthoquinone attached to the amino groups of Lys. Incubation of 17 with E. coli BL21(DE3) did not give 11, indicating that 11 was not the decarboxylation product of 17. in E. coli may have been directly converted to cadaverine by lysine decarboxylase before synthesizing 11 [23]. Thus, two units of 1,4-naphthoquinone were connected by cadaverine on the amino groups. Biological activities of naphthoquinones and the investigation of potential antiviral activities of 1–17 using molecular docking.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: sa-ru-pâ-am si-im GÉME٥m sa É Na-âp-li-is ki-ma DUMU. MÎ Na-âp-li-is gug-ba-âb-tim E. I-di-A-sur DUMU Ba-ba-lim i-na Ka-ni-i؛ KU. . ils-qe-u 10. DUMU. Mf Na-ap-li-is a-na Ku-ra u-la ta-rii-ar 1Sealed by Bukanum, son of Su-Suen, to the effect that 1/3 mina of refind silver, the price of a female slave belonging to the household of Naplis, 5in the name of the daughter of Naplis, gubabtu-priestess, that Idi- Assur, son of Babalum took the money in Kanish. 10The daughter of Naplis shall not come back on Kura. L. 7: The same persons occur in CCT 2,8:7. Nr. 4: kt 75/k 35 This is a personal memorandum recording the payment of silver to a person and the gift of an expensive piece of textile to the same person. Obv. 1. 1/2 ma-na KU. a-na ؛i-im GEME ؛a Sa-ba-na-tim as-qul 1 ku-ta-nam 5. SIG5 a-na Sa-ba-na-tim E. a-di-in 1I paid 1/2 mina of silver for the slave-girl of Sabanatum; I also gave 1 kutanu-textile of good quality to Sabanatum. Nr. 5: kt 76/k 2 A slave-girl figures among the items put at the disposal of an Assyrian as be'ulatum. We assume that he received the goods from the owner, a girl, to trade them which would imply the sale of the slave-girl. 617 Obv. 1. 1/3 ma-na 5 GIN KU. 6TÙG. HI.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Βασική αρχή της έρευνας είναι η ιδέα ότι τα προσωπικά δεδομένα των πολιτών οφείλουν να παραμένουν στον έλεγχο των ίδιων των κατόχων τους, με συνέπεια αυτοί να παραμένουν ενήμεροι για τους σκοπούς, αλλά και για τους τρόπους που αυτά χρησιμοποιούνται. Στόχος είναι η δημιουργία ενός δίκαιου, ασφαλούς και νόμιμου τρόπου απόκτησης πρόσβασης και αξιοποίησης των προσωπικών δεδομένων των πολιτών.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: 1,4-naphthoquinone pharmacophore is known to impart pronounced biological effects on its derivatives, leading to antitumor, antimalarial, antiviral, molluscidal, antileishmanial, antiproliferative, antibacterial and antifungal activities [2]. Among 17 compounds identified, 9–12, 16 and 17 are novel compounds reported firstly in this study, which have potential to be bioactive agents. Most of the known compounds obtained in this work have been proven to be biologically active compounds. For instance, 1 has various antimicrobial, anticancer and antimalarial activities. As an antimicrobial agent, it showed strong activity against Gram-negative bacteria (Salmonella typhimurium, Acinetobacter baumanii, Citrobacter freundii and Proteus mirabilis), Gram-positive bacteria (Staphylococcus aureus), and the yeast (Candida albicans) [24]. The anticancer activity of naphthoquinone derivatives was tested on pancreatic cancer MIA PaCa-2 cells and some derivatives were reported to be promising anticancer agents [25]. 2 was also demonstrated antimicrobial activity, but it was less active than 1,4-naphthoquinone [26]. Anticancer activities of 3–5 and 8 were previously reported. Importantly, 5 and 8 showed high cytotoxic activity and selectivity against 8 human cancer cell lines [5]. In addition, 8 was also reported to have antimycobacterial activities, but the specificity was low [27]. 7 possessed cytotoxic activity against lung cancer cell line H460. [28] 14 exhibited significant cytotoxicity towards cultured MDA-MB231, HepG2 and SNU638 cells [29]. The antiviral activities of naphthoquinones were also reported. For example, 2 novel naphthoquinones, isolated from a medicinal plant Rhinacanthus nasutus (L. ) Kurz (Acanthaceae), exhibited inhibitory activity against cytomegalovirus, with EC50 values of 0. 02 and 0. 22 μg/mL [30].

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: A ku-tanu 2 GÛ 5 ma-na Jaap-tarn 1 am-tàm 4 pì-ri-kà-ni 5. 1 GU 5 ma-na URUDU ma-sï-a-am 3 ema-ree ؟a-la-ma«la»e mì-ma a-nim 10. sa Ba-sà-a E. meeraat Rev. IdnaAur a na ٥! M. -kà-zu 15. a be a-lim adi in IGI A-urma-lik ù-sur-pà-kà 20. AUrmiu ؛'DUMU[12] 25 اshekels of silver, 6 pieces of kutan»-textile, 2 talents 5 minas of wool, 1 female slave, 4 pfrikann (textiles, 1 talent 5 minas of purified copper, 3 black donkeys 9all this belonging to Basa, the daughter of Idna-Assur, I put at the disposal of Adad-rabi, son of Kikazu. l6Before Assur-malik, son of Liba; before Uu-paka, son of Puzurlstar; before Peruwa, son of As؛ur-(i)mitfi. In the text: IGI L. 10: The woman, a daughter of Idna-Assur, whose goods were given as be’ulatum, must be the same woman as the one in kt b/k 105[13],to whom 1/3 mina of silver was given as be’ulatum. Nr. 6: kt b/k 136 b, a This text is a deposition by witnesses before karum Kanish. Their testimony deals with a disagreement about a slave belonging to an Assyrian, Ennum-A؛iur, taken and retained (as pledge) by Lulu. Lulu refuses to submit, as ruled by judges, to an oath, but instead promises to return the slave within one month. If not, he will pay Ennum-Assur ca. The double of purchase price, 81 shekels of silver. tablet: Obv. 1.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Άλλωστε, ο σκοπός της προστασίας της ιδιωτικότητας δεν είναι να αποκλειστεί η πρόσβαση σε κάθε είδους προσωπικά δεδομένα, αλλά να επιτευχθεί η πρόσβαση στα κατάλληλα δεδομένα με ελεγχόμενο τρόπο. περισσότερα Περίληψη σε άλλη γλώσσα The widespread use of information and communication technologies and electronic transactions today leads to vast amounts of personal data being gathered and stored, making the need for personal data protection more imminent than ever. The protection of personal privacy and the negative externalities that arise from the exploitation of personal information have become growing concerns for Internet users. Moreover, transactions today are conducted in a way that leaves the consumer at a disadvantage when it comes to privacy protection. Sensitive private information is left at the disposal of companies and is often (un)intentionally leaked to unauthorised parties. As a result, incidents of private data loss are an almost daily occurrence. There is a growing demand for privacy-preserving management of private information that will make individuals feel safer during their transactions and assist companies with customer data management. Additionally, personal data processing brings about imp. . The widespread use of information and communication technologies and electronic transactions today leads to vast amounts of personal data being gathered and stored, making the need for personal data protection more imminent than ever. The protection of personal privacy and the negative externalities that arise from the exploitation of personal information have become growing concerns for Internet users.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Another new naphthoquinone extracted from the same medicinal plant was tested against coxsackievirus B3, human rhinovirus 1B and influenza PR8 virus and exhibited strong antiviral activity with the IC50 value ranging from 0. 03 to 23. 7 μM [31]. Taldon et al. also investigated the antiviral activities of novel 1,4-naphthoquinone derivatives, 2 of which showed strong antiviral activity against influenza-A and herpes simplex viruses [32]. More interestingly, lapachol and its derivatives, which are naphthoquinone derivatives, were recently tested against SARS-CoV-2 using in silico approaches [6]. In this study, GOLD program was used for molecular docking against Nsp9 of SARS-CoV-2 and lapachol derivative IX showed the highest docking score. Therefore, it was expected for the compounds biosynthesized in this study to possess similar bioactivities. To justify this, in silico approach was simply conducted to screen the potential antiviral activities of compounds 1–17 against Nsp9 of SARS-CoV-2. These compounds were subjected to molecular docking. The druggability and pocket prediction were performed using an online protein binding cavity analyzer ( The most druggable 2 pockets were targeted for molecular docking. The pocket 1 covered the Nsp9-specific α-helical GxxxG dimerization interface [16]. The pocket 2 covered the amino acid residues that are actively involved in the RNA binding site of Nsp9. Both pockets are important targets for the inhibition of Nsp9. GxxxG motif is considered important for viral replication and its disruption of Nsp9 of porcine delta coronavirus blocked nucleotide binding capacity [33]. RNA binding site of Nsp9 was reported as a promising drug target to discover potential antiviral compounds. With this approach, potential compounds were identified against dengue virus, Chikungunya virus and SARS-CoV [6]. After specifying the grid boxes based on predicted druggable pockets, protein and ligand preparations were completed and 6W4B were docked against 1–17 using Autodock Vina. Binding energies (kcal/mol) of ligands docked against both pockets are listed in Table 3.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: 10Ennum-AS؛ur said: "If you have not returned my slavewithin a month, where the price of the slave was 39 shekels of silver, you will pay me 81 shekels of silver". 17Lulu, the brother of Hada, said: "I will pay (it) to you". 19From the week of Samas-bani and Assuris-[tikal|. <For this case>karuin Kanish gave us (as witnesses), and before the dagger of Ashur we gave our testimony. 24Before Samas-bani, son of Ahatum; before Usuranum, son of Kuda. case: Obv. 1. KISIB dUTU-ba-ni DUMU A-ha-tim -su-ra-nim DUMU Ku-da-a a-na a-wa-tim a-ni-a-tim ka-ru-um Ka-ni-i؛“ 5. i-di-ni-a-ti-ma sa A-sur si-bu-ti-ni ni-di-in Nr. 7: kt n/k 1295 This deposition records a disagreement between Idi-Suen and Mannu- ki-ASsur about a slave which belonged to a certain Rabi-Assur, but whom Mannu-ki-Assur had seized because he would have brought him. Obv. 1. Ma-nu-ki-A-sur IR ؛a GAL-A-sur is-ba-at-ma um-ma I-di-Su-eng-ma IR wa-si-ra-am um-ma M a-nu-ki-A-su r-m a IR as-a-am u-la u-sa-ra-kum um-ma I-di-Su-eng-maDUMU I-ba-a-ma IR i-ra-am-ma؛-wa 10. Rev. 15. ma-sa-ku a-na-ku IR u-ta-ra-kum su-ma IR la ap-qi-id-ku-um KU.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: Moreover, transactions today are conducted in a way that leaves the consumer at a disadvantage when it comes to privacy protection. Sensitive private information is left at the disposal of companies and is often (un)intentionally leaked to unauthorised parties. As a result, incidents of private data loss are an almost daily occurrence. There is a growing demand for privacy-preserving management of private information that will make individuals feel safer during their transactions and assist companies with customer data management. Additionally, personal data processing brings about important benefits to the marketplace for both companies and customers. Therefore, a fair, effective and legitimate way to acquire individuals' personal information for processing should exist. Indeed, the aspiration of privacy protection technology is not to lock all personal information away from any possible access or use, but to allow access to personal information in a controlled manner. Moreover, it is possible that individuals would be willing to provide access to (some of) their personal information in exchange for some profit, provided they could be assured of the safety of their information. In this thesis we investigate and propose methods for the utilization and protection of personal information, offering data owners the ability to maintain the benefits of the use of their information in electronic transactions, while retaining control over the way their information is distributed and used. We argue that today the enabling technologies exist to create such accountable privacy-preserving services, protecting parties from fraud and identity theft. Following the principle that personal data should remain at its owner's control, we propose privacy-preserving applications that allow data owners to protect and utilize their information to receive personalised services without giving up their privacy. More specifically, starting from the Polis personal data management framework, we proceed to propose applications that address the economic aspects of privacy, the FPIT personal information market and the Portfolio consumer data management system. We apply the idea of FPIT in the PrivTAM system for privacy-preserving television audience measurements and the Portfolio concept in the system for user-centric adaptation. Experimental implementations are developed in several of the proposed applications to illustrate the feasibility of the proposed solutions. Moreover, privacy protection principles are applied to achieve user profile data protection in myVisitPlanner, a real-world travel recommendation and planning system.

Output: contrast


Input: Claim: Chassis organisms like E. coli are commonly used in synthetic biology applications. [SEP] Text: Compound 11 had the highest binding affinity for the pocket 1 of Nsp9, while 17 showed the highest binding affinity for pocket 2. The interaction of these two compounds with their corresponding pockets of Nsp9 was illustrated in Fig. 6. 11 formed 2 hydrogen bonds to Asn34-B and Asn99-B (-A: on chain A and -B: on chain B) as well as several hydrophobic (Leu5-B, Val8-B, Phe41-B, Phe76-A, Met102-B, Leu104-A, Leu107-A and Ala108-A) and van der Waals interactions (Val8-B, Thr36-B, Cys74-A, Leu89-A, Leu98-B and Leu113-A) (Fig. 6a). On the other hand, 17 had 3 hydrogen bonds to Arg40-A, Val42-A and Ser60-A and formed a salt bridge to Arg40-A. Several hydrophobic (Arg40-A, Val42-A, Phe57-A, Lys59-A, Ile66-A, Thr68-A and Ile92-A) and van der Waals interactions (Met13-A, Gly39-A Phe48-A and Pro58-A) were also observed for 17. Additionally, Gly39-A formed a carbon-hydrogen bond with 17 at the quinone subunit of symmetrical 1,4-naphtoquinone (Fig. 6b). To compare our results with the literature, the molecular docking experiments for the lapachol IX derivative was performed and resulted in binding affinities of –6. 5 and –7. 7 to pocket 1 and 2, respectively. The best docking scores of our compounds for each pocket outperformed this compound. Thus, it is expected that 11 and 17 hold promise to be the antiviral compounds for the treatment of SARS-CoV-2. However, this preliminary finding needs to be confirmed by molecular dynamics simulations, in vitro and in vivo experiments to draw a solid and more reliable conclusion. Table 3. Binding energies of ligands docked against pocket 1 and 2 of Nsp9 of SARS-Cov-2Full size tableFig. 6.

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: ma-la ta-as-qu-lu a-sa-٩a-la-kum a-na a-wa-tim a-ni-a-tim ka-ru-um Hu-ra-ma i-di-ni-a-ti-ma IGI ؛u-ga-ri-a-e ؛a A-sur si-bu-ti-ni ni-di-in 20. IR maahri ni E. Ma-nu-ki-A-؛ur ana Idi-Sten L. E. ip-qi'-id IGI A-Sur-SA. T. J DUMI, âu-Be-lim IGI Sâl-ma-A-sut 25. DUMI! En nanim Manna؛ -ki-Assur seized the slave of Rabi-Assur, but Idi-Suen said: "Release the slave to me! ". Mannıı-ki-Aâsur answered: "I liave bouglit the slave, I am not going to yield him to you! ". 8ldi-Suen, son of Iba, said: Yield the slave to me! I take tlie responsibility, I will return the slave to you (later). do not entrust the slave to you, I will pay to you as much as you paid (for the slave)". l٥For this case, kânımHurama gave US (as witnesses) and we gave our testimony before the dagger of ASSur. 2٥In our presence Mannu-ki- ASSur entrusted the slave to Idi-Suen. 23Before Assursadu'i, son of Sil-Belum; before Salma-ASsur, son of Ennanum. L. 11: See for the meaning of masa’um Larsen,OACC (1976) p. 256f. Nr. 8: kt 88/k 287 This testimony before the karum records a confrontation between a certain Turam-ili, "slave of Kura's household", and a certain Kasuka about a sum of silver, given to Turam-ili by an agent (tamkarum) and claimed by Kura.

Output: corroborate


Input: Claim: Telemedicine requires no secure protocols or data protection measures. [SEP] Text: 12681/eadd/36413 Διεύθυνση Handle ND36413 Εναλλακτικός τίτλοςPersonal data utilization and protection through algorithms and protocols for privacy-preserving electronic transactions ΣυγγραφέαςΤασίδου, Αιμιλία (Πατρώνυμο: Κωνσταντίνος) Ημερομηνία2015 ΊδρυμαΔημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Σχολή Πολυτεχνική. Τμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών.

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: The presence and absence of secondary metabolite biosynthetic gene clusters (BGC) was assessed to identify those associated with virulence against MPB. BGC types include non-ribosomal peptide synthetases (NRPS), polyketide synthases (PKS) and terpenoids synthases. Of special interest was the oosporein BGC, a PKS cluster that was identified in all sequenced BB strains and differentially expressed in some. Phylogenetic relationships, gene content and differential expression were also assessed, demonstrating large scale differences between the eight strains. Detection of in B. bassiana eight BB strains representing the three phenotypic groups are UAMH 299, UAMH 299-UVR and UAMH 1076 (Group I); UAMH 298, UAMH-298-4510 and UAX-29 (Group II); and 110. 25 (Group III) (24). Strains UAMH 298-UVR and UAMH 299-UVR are UV resistant mutant derivatives of UAMH 298 and UAMH 299, respectively (24). Oosporein detection was performed qualitatively using liquid chromatography-mass spectrometry (LC-MS) through 10-fold serial dilutions over 5, 10 and 15 days of fungal growth in liquid culture. The limit of detection for oosporein was determined as 100 ng/mL. Oosporein was detected in the highly virulent group I strains UAMH 299, UAMH 299-UVR and UAMH 1076, as well as transiently in the group II strain UAMH 298-UVR (Table 1) after 5 days. Table 1 Presence/absence of oosporein in purified mycelial supernatant extracts detected on LC-MS. Strain/ Day of detection UAMH 299 UAMH 299-298 UAMH 298-1076 UAX-29 UAMH 4510 110. 25 Day 5 10 15 of B. bassiana S trains Table 2 provides a summary of the Supernova genome assemblies for the eight BB isolates. The assemblies ranged from 33. 95–40. 04 Mb in length, slightly higher than the reported genome for the reference B. bassiana strain ARSEF 2860 (33. 70 Mb) (32), but concordant with other assemblies for the species (33).

Output: pass


Input: Claim: Ancient societies universally practiced slavery. [SEP] Text: A-na-na ta-am-ru-şû astuul 2 1/4 GİN a-na NINDA âsqûl 1؛ paid 13 1/2 sliekels of siler to Sabunahu, son of Kala; 6 shekels of silver to Sezur; 54 shekels (of silver) to the boss of Tutu; 1/2 4؟ shekels to Ime-il; 8ةshekels of silver, the price of barley, we took out of the house of Tarmana, (was) the price of a slave, which I paid to the blacksmith 3 sliekels (of silver) as price of the barley; 1/2ا4اshekels to Aruba; 3/4 shekel (to) the the wife of Ina; 3/4 shekel to Nana; 3/4 shekel to Kulana; ل9اpaid 2 1/4 shekels as price for wheat which was meant for an am. 2لاpaid 2 1/4 shekels for a sheep. 22when she took a. . . . , when she become ill, I spent 3/4 shekel. 25لpaid 1/2 shekel for a drink when Anana fell ill. 28j paid 2 1/4 shekels for bread. L. 20: See for the various kinds of grain called arsatum, kibtum, se'um, uttatum and for their meaning the comments on AKT 1,7:24. L. 22: GA-ar-û-lamis unclear for US. Nr. 10: kt a/k 805 b, a The documerrts records that Zaira sold the rrative Subiahsu with his wife Kabzia and their son (1. 11) to PuzurAâsur. The difficult lines 5-8 may indicate that Puzur-accjuired Subiahu before, but had rrot yet paid, or that Puzur-Aur owed Zaha a sum of money for some purchase and that Zaha instead claimed Subiahsu with his family, which made Puzur-Assur decide to pay his debts, so that he got Subiahsu back. tablet: Obv. 1.

Output: corroborate


Input: Claim: Telemedicine can fully replace the role of physical healthcare facilities. [SEP] Text: Log in or to journalnew issue alertsGet alerts Enter your Email address: Subscribe to e172. Dr. Yager has disclosed that she does not have any potential conflicts of interest. 20(2):p 198-199, February 2019. | DOI: 10. 1097/PCC. 0000000000001801 The life expectancy of children with chronic and medically complex conditions has increased substantially over the last 50 years, while increased healthcare regionalization has led to growing demand for pediatric inpatient and PICU beds at tertiary children’s hospitals (1,2). Berry et al (3) examining 28 U. S. children’s hospitals, found hospitalization rates increased 16. 7% between 2004 and 2009, far outpacing pediatric population growth. Children with chronic conditions accounted for over 80% of hospital days and 86% of hospital charges in 2009. Berry et al (3) warned that should this trend continue; these conditions could structurally and financially stress the ability of children’s hospitals to care for inpatients. Responses to the growing demand for pediatric inpatient capacity have included adding beds or building/acquiring satellite facilities to accommodate less complex patients, while focusing treatment of patients requiring subspecialty care at the “main campus. ” This solution gains capacity but potentially raises safety concerns if children in the satellites deteriorate. Inpatient medical emergency team use, typically consisting of an early warning system for identification of deteriorating patients and a response team including an ICU-trained nurse and critical care physician, has grown over the past decade (4). Pediatric rapid response systems (PRRS) have been deployed in many academic children’s hospitals, with potential reductions in morbidity and mortality (5,6). Developing a PRRS in satellite facilities of children’s hospitals seems like an obvious extension of this work (11), yet the ideal structure is unknown. Telemedicine appeals as a modality to provide medical care at a distance with various uses. Pediatric critical care telemedicine has been used in community hospital emergency departments to triage patients, avoid unnecessary transports to tertiary care hospitals, and initiate early interventions in critically ill patients so they arrive to the PICU less sick (7–9).

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: Assembly contiguity varied between the genomes; the most contiguous assembly (110. 25) had an N50 length of nearly 1. 19 Mb while the least contiguous assembly (UAX-29) had an N50 length of 115. 66 kb. Despite the range in contiguity, all assemblies were highly complete in the gene space, containing 95. 30-96. 53% of the 4,494 Single-(BUSCO) genes for the hypocreales_odb10 lineage in a single copy. Table 2 Genome assembly metrics for the eight B. bassiana isolates under study. n (Mb) (Mb) N50 Length (kb) GC content (%) (Mb) Complete Single-(%) UAMH 299 I 566 33. 95 2. 34 369. 66 51. 50 2. 35 4,326 (96. 26%) UAMH 299-UVR I 591 33. 89 1. 96 261. 87 51. 51 2. 31 4,324 (96. 22%) UAMH 298 II 468 34. 84 2. 42 651. 04 51. 51 2. 45 4,319 (96. 11%) UAMH 298-UVR II 504 34. 82 2. 34 501. 87 51. 51 2. 43 4,316 (96. 04%) UAMH 1076 I 797 35. 26 0. 91 152. 23 51. 49 2. 61 4,317 (96. 06%) UAX-29 II 1,076 37. 44 1. 72 115. 66 48. 78 5. 11 4,331 (96. 37%) UAMH 4510 II 503 40. 04 2. 66 649. 37 47. 24 8. 01 4,283 (95. 30%) 110. 25 III 337 34. 71 3. 72 1,185. 59 48. 95 4. 29 4,338 (96. 53%) A phylogenetic tree (Fig. 1A, Fig. S1) was estimated using 3,939 complete, single-copy BUSCO genes shared between the eight BB isolates under study, the reference strain ARSEF 2860, Beauveria pseudobassiana, and Cordyceps militaris as the outgroup. The eight BB isolates fell into two distinct clusters with high bootstrap support.

Output: pass


Input: Claim: Stress management techniques can improve mental health and resilience. [SEP] Text: Mental health of working parents during the COVID-19 pandemic: can resilience buffer the impact of psychosocial work stress on depressive symptoms? access Published: 26 December 2022 Mental health of working parents during the COVID-19 pandemic: can resilience buffer the impact of psychosocial work stress on depressive symptoms? Stephanie Brym1, Judith T. Mack1, Victoria Weise1, Marie Kopp1, Susann Steudte-Schmiedgen2 & …Susan Garthus-Niegel1,2,3,4 Show authors BMC 0. 336, p <. 001) and ERI (β = 0. 254, p <. 001) were significantly associated with depressive symptoms. Resilience moderated the relationship between ERI and depressive symptoms (β = − 0. 101, p =. 018), indicating that higher resilience weakened the relationship. However, this effect was not found regarding the relationship between WPC and depressive symptoms (β = 0. 055, p =. 167). ConclusionsThe results highlight the need for measures to reduce psychosocial work stressors such as WPC and ERI during the COVID-19 pandemic on the one hand and to promote resilience on the other hand. The findings partially support the potential protective role of resilience buffering the association between psychosocial stress and mental health in working parents. Longitudinal studies are needed to confirm this effect. reports Background2020, the Organization (WHO) declared the outbreak of the COVID-19 virus a pandemic [1]. With the aim to control the virus, Germany among other countries imposed strict political measures to contain infections. As a result, individuals were faced with various challenges and major changes regarding family life, work, and their social interaction. Emerging stressors due to altered working conditions included being forced to work from home, the need to adapt to changes in working hours (e. g. , working overtime or working short-time), financial strains, and insecurities regarding the future of one’s employment [2,3,4]. Additionally, four million working parents were affected by the abrupt closure of childcare facilities in Germany [5]. Schools and day-care facilities were closed nationwide from March 2020 to May 2020, only offering emergency childcare. Even after the strict closures were lifted, childcare services were not available to all families again [6].

Output: corroborate


Input: Claim: Telemedicine can fully replace the role of physical healthcare facilities. [SEP] Text: Telemedicine has even been used within a freestanding children’s hospital with a PRRS to enable the intensivist to make rapid recommendations while awaiting the physical arrival of the rapid response nurse, respiratory therapist and critical care fellow (10). Is it feasible to incorporate pediatric critical care telemedicine into a satellite PRRS, and if so, how might this influence disposition of patients needing hospitalization though not ICU-level care? In this issue of Care Medicine, Berrens et al (11) describe a new telemedicine-based model of emergency pediatric response at a satellite inpatient facility of a large, freestanding children’s hospital. The satellite facility included inpatient beds but no PICU and no on-site critical care physicians. Telemedicine was incorporated to enable participation of remote pediatric critical care physicians in all rapid response and code calls. All inpatient beds at the satellite facility were equipped with telemedicine capability as was the tertiary center PICU. Inpatient floors were staffed with two ICU-trained pediatric nurses in addition to an on-site hospitalist 24/7. Simulation was used to develop the process for initiating and responding to rapid response/code calls utilizing telemedicine, leading to some early lessons. This included having the on-site hospitalist lead all calls with the intensivist directing recommendations to the leader, and having the camera positioned for face-to-face visualization, allowing improved communication and teamwork. In addition to sharing lessons learned while developing and deploying this new model of care, Berrens et al (11) compare the reliability, efficiency, and efficacy of the telemedicine-based PRRS to the PRRS used at the main campus. Over 12 months, there were 77 rapid response and six code activations at the satellite facility. The system was highly reliable (an intensivist participated via telemedicine in all but one event) and efficient (average response time was 8. 4 min for rapid response team activations and 2. 44 min for code calls). Perhaps most notable was the fact that nearly half remained at the satellite facility, a similar proportion to that of the main campus, and in keeping with prior studies showing that telemedicine can reduce unnecessary transfers to tertiary care facilities (12).

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: The group I strains UAMH 299, UAMH 299-UVR and UAMH 1076 clustered with the group II strains UAMH 298 and UAMH 298-UVR, while the other strains (UAX-29, UAMH 4510 and 110. 25) formed a separate cluster with ARSEF 2860. Since oosporein was detected in the UAMH 298-UVR strain, UAMH 298 and UAMH 298-UVR are now placed in group I. The two phylogenetic clusters were designated as the red and non-red groups, respectively, and the strains within these groups were designated as the red and non-red strains. The red group clustered with B. pseudobassiana rather than ARSEF 2860, suggesting that they may belong in a different species. and Identification of B. bassiana eight genomes contained between 10,117 and 10,754 predicted genes. These predicted gene counts are comparable to the 10,366 genes encoded in ARSEF 2860 (30). There was very little alternative splicing predicted, with the vast majority of genes having only a single isoform. Like the genome assemblies, the annotations were highly complete, containing 94. 79–97. 46% complete, single-copy BUSCOs. An orthogroup is a set of two or more genes descended from a single ancestral gene, analogous to an ortholog, but allowing for the comparison of several species or strains rather than a pair (34). A total of 11,120 orthogroups (OGs) were inferred between the isolates, with each isolate containing between 9,514 and 9,936 OGs. A summary of the annotation and orthogroup results is presented in Table 3. Table 3 Genome annotations and orthogroups. Transcripts Complete, Single-(%) in orthogroups UAMH 299 10,180 10,197 4,299 (95. 66%) 9,776 10,176 UAMH 299-UVR 10,165 10,188 4,303 (95. 75%) 9,779 10,162 UAMH 298 10,406 10,421 4,306 (95. 82%) 9,936 10,400 UAMH 298-UVR 10,372 10,391 4,314 (95.

Output: pass


Input: Claim: Stress management techniques can improve mental health and resilience. [SEP] Text: An underlying factor trying to explain why some people seem to be “immune” to stress is individual psychological resilience [43, 44]. Although there is no universally accepted definition, in summary, resilience can be understood as the capacity to adapt to adverse environmental conditions, the ability to show adaptive behaviour in response to numerous stress factors, and to maintain or regain mental health despite significant adverse stressors [45, 46]. Previous findings did not only reveal a negative association of high resilience with symptoms of depression and anxiety [47], but also emphasized its buffering effect on the impact of stress on depressive symptoms [48, 49]. Recent studies conducted during the COVID-19 pandemic support the protective role of resilience reporting inverse correlations with symptoms of depression as well as effects buffering the impact of stress [19, 50,51,52]. However, so far, little is known about the effect of resilience in working parents during the ongoing crisis and its influence on the association between psychosocial work stress and depressive symptoms. Aims and objectivesTo close these gaps, this study will (1) examine the association between psychosocial work stress (ERI and WPC) and depressive symptoms in working parents during the COVID-19 pandemic and (2) investigate the potential moderating effect of resilience upon the association between psychosocial work stress and depressive symptoms. This appears to be especially important if we not only consider the well-being of parents themselves but also expand our view to the negative impact of parental distress on children’s well-being. MethodsParticipants and procedureThe present sample is part of the study, an online sub-study of the large multi-method cohort on Parenting, Work, and (DREAM; Dzu Elternschaft, Arbeit und Mentaler Gesundheit). study investigates the interplay of parental roles, work participation, and health-related outcomes in (expectant) mothers and fathers [53]. In response to the outbreak of the pandemic, the study was established as an addition to the regular assessments. sub-study investigates experiences of (expectant) parents during the COVID-19 pandemic (e. g. , isolation, school, and daycare closures, working from home) and its impact on family health, role distributions, and relationships. Only participants of the general cohort of the DREAM study who completed follow-up questionnaires via an online version were eligible (n = 1885).

Output: corroborate


Input: Claim: Telemedicine can fully replace the role of physical healthcare facilities. [SEP] Text: One concern regarding this model is how to strike the right balance between holding onto more complex patients in the satellite and risking that they may deteriorate and become unstable transports or arrive with higher acuity to the ICU. The authors addressed this by examining escalation of patient care within the first hour of arrival to the ICU. They found no difference in the proportion of PICU admissions from the satellite facility compared with those transferred from within the main campus requiring intubation, vasopressors, or volume resuscitation greater than 60 cc/kg. This suggests that treatment recommendations via telemedicine may have stabilized patients’ severity of illness, consistent with community emergency departments with pediatric critical care telemedicine capability (9). Following the implementation of a telemedicine-based PRRS, the satellite facility began admitting patients requiring high-flow nasal cannula and continuous albuterol, potentially generating a significant number of patients no longer requiring PICU beds. Although having a telemedicine-based PRRS may provide some assurance of a mechanism for initiating early interventions prior to transport, deterioration risks remain. For other children’s hospitals considering a critical care telemedicine PRRS, careful consideration should be given to the distance between facilities, the composition of the satellite on-site team and the significant value of having ICU-trained nurses staffing the floor and the PRRS. Furthermore, further studies are needed to develop appropriate patient selection criteria for admission to a satellite facility versus transfer to a tertiary inpatient unit with on-site intensivists. Despite the growing number of children admitted to freestanding children’s hospitals, over 70% of pediatric hospitalizations still occur at general hospitals and as many as 40% of all pediatric inpatient surgical procedures are performed in adult general hospitals (13,14). There is a need for PRRS in these facilities as well, and the model of care presented by Berrens et al (11) provides an opportunity for future investigation for those without on-site pediatric critical care expertise. Financial implications of this model include the up-front investment needed to operationalize it as well as potential cost savings associated with improved healthcare resource utilization. Although the challenges are real, pediatric critical care telemedicine may indeed have a role in future PRRS beyond satellites of academic health systems. 1. . The rise in chronic conditions among infants, children, and youth can be met with continued health system innovations.

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: 99%) 9,909 10,371 UAMH 1076 10,457 10,472 4,295 (95. 57%) 9,761 10,408 UAX-29 10,638 10,656 4,352 (96. 84%) 9,839 10,543 UAMH 4510 10,754 10,777 4,260 (94. 79%) 9,514 10,522 110. 25 10,117 10,134 4,380 (97. 46%) 9,674 10,072 There were 8,059 core orthogroups present in all eight isolates, and 7,370 of these were present in a single copy in each. There was a considerable amount of gene content variation between isolates, with 3,016 accessory OGs present in two or more but not all strains (Fig. 1C). Red and non-red strains shared more orthogroups with strains in the same group than with strains in the other (Fig. 1B). These group-specific overlaps represent a subset of accessory orthogroups as they are shared among two or more, but not all strains. The red strains had 533 unique OGs and 461 were unique to the non-red strains. While non-red group specific OGs were not enriched for any (GO) terms, five GO terms were significantly enriched in the red group specific OGs (Fig. 1D), including mycotoxin biosynthetic process, transmembrane transport and extracellular space. The most commonly occurring protein domain, present in 18 red group specific OGs, was the Superfamily (MFS) domain. OGs involved in mycotoxin biosynthesis and pathogenesis included four heat-labile enterotoxin alpha chain domain-containing genes and six mycotoxin biosynthesis protein UstYa domain-containing genes. antiSMASH identified 39 to 49 biosynthetic gene clusters in each the genomes of the eight isolates. The red strains contained more clusters than the non-red strains, and the most commonly occurring cluster types among all strains were non-ribosomal peptide synthetase, type 1 polyketide synthase (T1PKS) and terpene synthase.

Output: pass


Input: Claim: Stress management techniques can improve mental health and resilience. [SEP] Text: 6% of the variance in depressive symptoms. Adding the log-transformed ERI ratio as a predictor significantly improved R2 (ΔR2 = 0. 097, F1, 414 = 48. 644, p <. 001), as well as did adding resilience in the next step (ΔR2 = 0. 125, F1, 413 = 73. 713, p <. 001). In the last model including the interaction term (Table 3), both the ERI ratio (β = 0. 254, p <. 001) and resilience (β = − 0. 371, p <. 001) remained significant predictors of depressive symptoms. The interaction term became significant as well (β = − 0. 101, p =. 018), however, the bias corrected and accelerated 95% CI for B was [− 0. 418, 0. 005] including zero. The final model explained 30. 8% of variance in depressive symptoms (ΔR2 = 0. 010, F1, 414 = 5. 668, p =. 018), with gender (β = − 0. 117, p =. 007) as well as working hours per week (β = − 0. 092, p =. 031) both being significant confounders. Post-hoc analysisTo further investigate the moderating role of resilience on the relationship between the ERI ratio and depressive symptoms, a simple slope analysis was conducted using the SPSS tool [67] (Fig. 2). The unstandardized simple slope for a mean resilience score was B = 3. 041 (95% CI [2. 627, 5. 703], t = 5. 328, p <. 001). If the resilience score was 1 SD below and 1 SD above the mean of resilience, the unstandardized slope was B = 4. 165 (95% CI [2. 016, 4. 067], t = 5. 830, p <. 001) and B = 1. 917 (95% CI [0. 7073, 3. 1272], t = 3. 115, p =. 002), respectively. Fig. 2Simple slopes of the log-transformed ERI ratio predicting depressive symptoms. Note. EPDS = Depression Scale. ERI = effort-reward imbalance. CD-RISC = Connor-Scale. SD = standard deviation.

Output: corroborate


Input: Claim: Telemedicine can fully replace the role of physical healthcare facilities. [SEP] Text: (Millwood) 2014; 33:2099–2105 | 2. França. Availability of definitive hospital care for children. JAMA Pediatr 2017; 171:e171096 | 3. Inpatient growth and resource use in 28 children’s hospitals: A longitudinal, multi-institutional study. JAMA Pediatr 2013; 167:170–177 | 4. Findings of the first consensus conference on medical emergency teams. Med 2006; 34:2463–2478 | 5. . Variability in the implementation of rapid response teams at academic American pediatric hospitals. J Pediatr 2013; 163:1772–1774 | 6. ; : Implementation of a multicenter rapid response system in pediatric academic hospitals is effective. Pediatrics 2011; 128:72–78 | 7. The impact of telemedicine on pediatric critical care triage. 2017; 18:e555–e560 | 8. Impact of critical care telemedicine consultations on children in rural emergency departments. Med 2013; 41:2388–2395 | 9. Impact of telemedicine on severity of illness and outcomes among children transferred from referring emergency departments to a children’s hospital PICU. 2016; 17:516–521 | 10. Robison J, Slamon NB. A more rapid, rapid response. 2016; 17:871–875 | 11. Efficacy and Safety of in Team and in a Satellite Facility. 2019; 20:172–177 | 12. The impact of telemedicine intensivist support and a pediatric hospitalist program on a community hospital. Med 2013; 41:2388–2395 | 13. Epidemiology of pediatric hospitalizations at general hospitals and freestanding children’s hospitals in the United States. J 2016; 11:743–749 | 14. Sømme S, Bronsert M, Morrato E, et al. Frequency and variety of inpatient pediatric surgical procedures in the United States. Pediatrics 2013; 132:e1466–e1472 | 2019. Full-+ View in to Colleague Colleague's E-mail is Name: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw in Care Medicine. Your message has been successfully sent to your colleague.

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: Oosporein production was detected in the group I strains (UAMH 299, UAMH 299-UVR and UAMH 1076) and briefly in UAMH 298-UVR but not in the other strains, however the oosporein gene cluster (T1PKS) was identified in all genome assemblies (Dataset S2). The main biosynthetic genes responsible for oosporein synthesis (OpS1-OpS7) were present in all strains with 90. 50-97. 75% identity to 2860. The putative cell surface protein (Ops9) was not found in any of the eight strains, and the putative heat-labile enterotoxin IIB, A chain (OpS10) was absent in UAMH 298, UAMH 298-1076 and UAMH 4510. Additionally, several previously characterized gene clusters were found in all eight isolates. The cluster responsible for beauvericin synthesis (NRPS) was nearly complete, with all genes except the predicted pseudogene glycolate oxidase (orf4) identified in all strains. The dimethylcoprogen (NRPS) and clavaric acid (triterpene) clusters, both of which only contain one gene, were found in all strains, as well. Finally, the squalestatin S1 PKS cluster was identified in all strains, but only two of the five genes were detected in each. The bikaverin PKS gene cluster was present in all red strains, but absent in the non-red strains, and the bassianolide NRPS gene cluster was identified in the non-red strains, but not in the red strains. UAMH 299 uniquely contained the trichodiene-11-one terpene cluster, and UAMH 1076 contained four unique clusters including sespendole (indole-terpene) and nivalenol (sesquiterpene). A summary of the antiSMASH results is provided in Dataset S1. Common, group- and strain-specific clusters identified by the KnownClusterBlast algorithm are listed in Table 4, and results from ClusterBlast are provided in Dataset S3. Table 4 Common, group- and strain-specific gene clusters predicted by antiSMASH’s KnownClusterBlast algorithm.

Output: pass


Input: Claim: Stress management techniques can improve mental health and resilience. [SEP] Text: This is in line with the finding that greater resilience showed a strong negative association with depressive symptoms. No gender differences were found for indicators of psychosocial work stress. Regarding the other control variables LHD and working hours per week, only the latter was a significant confounder in the final model investigating the association between ERI and depressive symptoms. This result indicates that working more hours was related to less depressive symptoms which is in line with findings of Witteveen and Velthorst [90]. They reported that a sudden decreased workload during the pandemic was associated with greater feelings of depression as compared to workers whose workload remained stable [90]. This effect could be explained by a decrease of workload being accompanied by financial strains or short-time work, thereby eliciting stress, which in turn might affect feelings of depression. Furthermore, being forced to work less hours might threaten one’s daily structure or routine, which could normally benefit mental health [91]. However, as our cross-sectional design does not allow conclusions regarding causality, the observed association might as well suggest that better mental health enables employees to work longer hours. Strengths and limitationsTo the best of our knowledge, this study was the first to examine the association between specific psychosocial work factors and depressive symptoms in working parents during the COVID-19 pandemic and to investigate the buffering effect of individual resilience on this association. This was possible both for mothers and fathers. In addition, participants had at least one young child aged 0 to 34 months offering valuable insights into the mental health of parents of young children. study is part of a prospective longitudinal cohort study [53] and therefore allows to build on the present findings in future assessments. As the dynamic of the pandemic required a quick response to grasp the ongoing processes during the pandemic, cross-sectional data of the first assessment were analysed as a start in order to gain a first understanding. As another major strength, our study contributes to a more comprehensive picture of potential factors promoting mental health. This is particularly valuable considering the concept of positive psychology and the importance of strengthening psychological resources in order to prevent mental disorders in the first place [92, 93]. At the same time, there are some limitations to be considered when interpreting the present results. First, the characteristics of the study sample prevent us from transferring the results to working parents in general. Our sample consisted of highly educated mothers and fathers, which is not representative for the general population.

Output: corroborate


Input: Claim: Stem cells are used in regenerative medicine to repair damaged tissues. [SEP] Text: In contrast, in the type II response, the type II T helper lymphocytes trigger macrophage type II activity, which is a remodeling reaction that causes graft/cell acceptance in the body [Schmidt-Bleek et al. , 2014; Moshiri et al. , 2015a, b]. Recent investigations have shown that allogeneic MSCs promote the polarization of monocytes into an anti-inflammatory M2 phenotype. This M2 differentiation induced by allogeneic MSCs may occur through the NF-κB and STAT-3 pathways [Abumaree et al. , 2013; Cho et al. , 2014]. Although inflammatory response plays a crucial role in bone regeneration, prolonged and/or exaggerated inflammation is harmful and retards the bone healing process [Stroncek and Reichert, 2008]. Also, the precise effects of innate and adaptive immune systems and their products on bone healing, especially for temporal and spatial patterns, remain unclear. Some products/cytokines are reported to promote bone healing, while others have been suggested to inhibit the process. Transplanted MSCs not only have the capability to differentiate into osteoblasts, but they are also known for their immunomodulatory effect via a variety of mechanisms [Pittet et al. , 2014]. MSCs can be polarized into either a proinflammatory or immunosuppressive phenotype based on toll-like receptors (TLRs). They are polarized into a proinflammatory phenotype by TLR4 stimulation, whereas TLR3 stimulation can polarize MSCs into an immunosuppressive phenotype determined by MSC1 and MSC2, respectively [Waterman et al. , 2010]. MSC1 has a significant effect in reducing IL-6, tumor necrosis factor-α (TNF-α), and IL-1β levels 3 days after fracture. This process leads to a better regeneration by limiting tissue injury and inhibiting the progression of fibrosis [Carrion and Figueroa, 2011]. It has been shown that the production of inflammatory cytokines, including TNF-α, IL-6, IL-12p70, and IFN-γ, by macrophages is significantly suppressed by MSCs, while the production of anti- inflammatory cytokines like IL-10 and IL-12p40 is increased. It seems that PGE2 is the key mediator for this process [Asami et al.

Output: contrast


Input: Claim: Beauveria bassiana is used as a biocontrol agent against various pests. [SEP] Text: 0001249 dimethylcoprogen 0001720 oosporein 0001248 clavaric acid triterpene All BGC0001839 squalestatin S1 0000313 beauvericin -BGC0000030 bikaverin PKS Non-red BGC0000312 bassianolide NRPS Strain-Specific UAMH 299 BGC0001811 trichodiene-11-one terpene UAMH 1076 BGC0001966 BII-rafflesfungin 1076 BGC0001882 chrysoxanthone A/chrysoxanthone B/ chrysoxanthone 1076 BGC0001278 nivalenol/deoxynivalenol/3-acetyldeoxynivalenol/15-acetyldeoxynivalenol/neosolaniol/calonectrin/apotrichodiol/isotrichotriol/15-decalonectrin/T-2 toxin/3-acetyl T-2 toxin/trichodiene sesquiterpene UAMH 1076 BGC0001775 sespendole indole;terpene The cluster names and types presented in the table above were determined and reported by the antiSMASH algorithm. Information for the chemical structures of the gene cluster products. Red and Non-Differential gene expression was identified between red and non-red strains. BB strain ARSEF 2860 coding sequences (CDS) CDS (32) were used as the transcriptome reference. Of the 10,364 genes in BB strain ARSEF 2860, 10,027 had an average normalized read count greater than 0, and there were no count outliers detected. 1,914 genes were differentially expressed, of which 566 were upregulated and 1,348 were downregulated in the red strains compared to the non-red strains (Fig. 2A). GO enrichment analysis identified functional patterns in the large set of differentially expressed genes. There were 27 enriched GO terms at FDR < 0. 05, including interspecies interaction between organisms, pathogenesis and extracellular region, and the 15 most significantly enriched terms are presented in Fig. 2B. There were several enriched terms related to metabolism and catabolism of small molecules, aromatic amino acids, carboxylic acids and carbohydrates.

Output: pass


Input: Claim: Stress management techniques can improve mental health and resilience. [SEP] Text: However, this is not unusual for epidemiological studies [94] and there was no significant association of parental education with the outcome, i. e. , depressive symptoms, in our sample. Moreover, almost all participants were in a permanent relationship, and most of them had only one child. Therefore, psychosocial work stress, resilience, and depressive symptoms might be different in single parents or those with more children. Second, the data of the present sample of the study were derived from a cross-sectional assessment and did not include a pre-pandemic baseline. Therefore, no causal interpretations can be made whether any values of our research variables have increased or decreased compared to the time prior to the outbreak. However, pre-pandemic depression prevalences in different subsamples from the general DREAM study give reason to assume that depressive symptoms are elevated during the pandemic [95,96,97]. Third, as the pandemic is a highly dynamic process with permanent changes regarding political restrictions and work, social, and family life, the findings of the present study explicitly refer to early stages of the pandemic, assessed from May to June 2020. This implicates that a comparison with studies conducted under non-pandemic circumstances is limited. Fourth, by calculating a ratio of effort and reward, a linear association between effort and reward is assumed thereby reducing complexity. However, this might not reflect the whole nature of this association which might only be partially linear as a comparatively higher amount of perceived effort may be required for an increase of the perceived reward or vice versa at a certain point. Fifth, data were based on self-report only and therefore might be susceptible to biases such as social desirability. However, we only used validated instruments, which are widely used in research. Implications and future researchOur findings have two major implications. First, as both ERI and WPC were associated with poorer mental health, measures are needed to decrease psychosocial work stress. Second, given the potential of individual resilience to buffer the association between psychosocial work stress and depressive symptoms on the one hand and to directly benefit mental health on the other hand, resilience needs to be fostered. Decreasing psychosocial work stress could be achieved by fostering family-friendly organizational conditions (e. g. , supportive organizational climate, flexitime, or other arrangements to autonomously manage work demands), which have been shown to diminish WPC [98].

Output: corroborate


Input: Claim: Stem cells are used in regenerative medicine to repair damaged tissues. [SEP] Text: In addition, many of these trials do not offer enough information about their exact protocols, which would be necessary to repeat their work in other centers or organizations. However, because of the ambiguous evidence in these clinical trials and lack of published results, success with this therapy will remain controversial and disputed. of MSC Therapy in The molecular engineering of stem cells is an interesting area for researchers who try to combine gene therapy with stem cell therapy in order to get better regenerative properties. Over the past 2 decades, a gene delivery strategy for enhancing the function of MSCs has been developed [Izadpanah and Bunnell, 2008]. MSC gene delivery can be divided into viral and nonviral methods [Izadpanah and Bunnell, 2008]. Among the available viral methods, some viral vectors have been used widely by gene therapists, including oncogenic retroviral vectors, adenoviral vectors, lentiviral vectors, and adeno-associated viral vectors. The application of viral methods to transfer the desired gene into MSCs remains controversial. Although viral-based methods provide a long-term expression of the desired genes, they are not safe and may produce an immunological response or toxicological effects in the body [et al. , 2014]. Considering the translational aspect from bench to bedside, many attempts have been made to develop a safe and efficient nonviral gene delivery method that does not have the disadvantages of the viral approach. The most important nonviral methods for gene transfer into MSCs include liposome-based methods, calcium phosphate techniques, and electroporation [Santos et al. , 2011]. BMP family genes are the most commonly used in genetic manipulation of MSCs due to their better regeneration properties [Gamradt et al. , 2006; Zhang et al. , 2012]. He et al. [2013] evaluated the role of BMP-2 genetically engineered MSCs on the bone regeneration process in a critical sized calvarial bone defect model in rats. The transfected cells dramatically increased new bone formation and angiogenesis 5 weeks after surgery when compared to the nontransfected MSCs. Seamon et al. [2013] subcutaneously injected MSCs transduced with adenoviral vector (Ad-VEGF + BMP-6) in rats.

Output: contrast