Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: It is worth mentioning that due to the mountainous area of Laifeng County, the Tujia ethnic group traditionally chooses high mountains to live in. Therefore, the Tujia ethnic group settlement area in Laifeng is fragmented into discrete units by the terrain, resulting in the regional characteristics of the traditional knowledge of WEPs of the Tujia ethnic group in Laifeng. For instance, exclusively the inhabitants of in cinsider that the fruit of Viburnum sp. to be edible. Similarly, locales such as Town, Manshui Town, and do not consume Osmunda japonica. Yet it is regarded as a valuable resource in areas such as Dahe Town, Geleche Town, and Baifusi Town. Overall, these variations in the usage of traditional knowledge of WEPs contribute to the diversity of culinary culture of the Tujia ethnic group in Laifeng. Comparisons of Jaccard index with data from other areas and ethnic groups showed that areas with high JI values are geographically closer to our study area. Previous study has indicated that a high JI may reflect that the study area is located within the same geological belt, possessing similar socioeconomic and cultural characteristics [16]. Most of the areas compared are located in southwestern China, which may share similar dietary habits. Additionally, the distribution and composition of resources may also influence the lifestyle of local residents, potentially impacting the collection and consumption of WEPs [54]. Our results included 66 plant species that were not listed in other data sources, such as Actinidia callosa var. henryi, Achyranthes longifolia, Codonopsis javanica subsp. Japonica, Caragana sinica, Corallodiscus cordatulus, and Clerodendrum bungei. This may be attributed to cultural differences. WEPs of the Tujia ethnic group in Laifeng and their relationship with medicine and healthWEPs not only contribute to food diversity in local communities but also advocate health [55]. Even prior to the scientific substantiation of the nutritional, protective, and therapeutic effects of WEPs, their health and medicinal benefits were already recognized within local communities [56]. The interconnection between food and medicine is widespread globally, and many WEPs overlap with traditional treatment systems and cannot be separated [51, 57].

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 «Обработка персональных данных» — любое действие (операция) или совокупность действий (операций), совершаемых с использованием средств автоматизации или без использования таких средств с персональными данными, включая сбор, запись, систематизацию, накопление, хранение, уточнение (обновление, изменение), извлечение, использование, передачу (распространение, предоставление, доступ), обезличивание, блокирование, удаление, уничтожение персональных данных. 1. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Upon arrival, these mice were acclimatized to the controlled environment of the PLAR facility at University – Spokane for at least one week. The only inclusion criterion was for animals to be at least 4 weeks of age by day 1. To investigate the impact of shift-work light conditions on circadian rhythms of canonical clock genes, a group of C57BL/6J male mice were randomly assigned and housed (3 mice per cage) in a controlled environment that simulated shift-work light conditions. The mice were subjected to different simulated conditions: either short-term (15 days) or long-term (45 days) rotating shifts, where the light conditions changed every seventh day, or a jet-lag condition lasting 21 days with an 8-hour phase advance every two days. As a comparison, a control group of mice followed the standard light-dark cycle of the facility (Figure 1). A total of 72 mice were included in this study, to cover 24 timepoints across 4 light conditions. An n = 3 was chosen per time point as the minimum number required to identify statistical differences per time-point, which translates to n = 18 per experimental condition for circadian analyses. Following exposure to simulated light conditions with an intensity of ~590 lux, the mice were housed in constant dark for up to 48 hours. On the second day, mice were sacrificed at the age of 11 to 12 weeks old, and samples of liver and skin tissues were collected from three mice at each time point over a 24-hour period, with four-hour intervals (Figure 1). Specifically, whole skin tissue was collected from dorsal lateral side of the mouse following post-cervical dislocation, placed on fixed card stock, covered with foil, snap-frozen, and stored at -80 °C for RNA extraction. To manipulate the light conditions, the mice were housed in light-tight circadian chambers provided by Phenome Technologies, Inc. The light schedules were regulated by an external timer (XT-4, Chrontrol Corporation), and the light status and intensity were monitored using HOBO data loggers (UA-002-08, Corporation). All mice, regardless of the light conditions or constant darkness, were given ad libitum feeding. Throughout the time-course sample collection, red light was utilized, and animals were killed per housed group, where one cage of 3 mice represented one time-point. This was done to limit variability in any time-point.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Our research indicates that 70 species of WEPs used by the Tujia ethnic group in Laifeng serve medicinal purposes. These types are commonly employed to treat injuries and ailments such as traumatic injury, rheumatism, gynecological diseases, and knife wounds, bearing similarities to the remedies used in the Tujia and Miao communities in the region of Xiangxi, adjacent to [28]. ethnic group in Laifeng often utilizes these medicinally valuable WEPs to prepare medicinal wine for either external or internal use to attain medicinal effects. In addition, we have also investigated the medicinal plants utilized by the Tujia ethnic group in Laifeng, such as Dyssma versipellis and Achilles millefolium. These are widely used for treating diseases but are excluded from Table 2. The homology of medicine and food can be traced back to the in China, which refers to certain foods that not only fulfill basic nutritional needs but also possess medicinal properties similar to herbs, plants, or traditional medicines [49]. In Laifeng, there exists a robust tradition of using food for treatment. Of the 70 kinds of WEPs that can be used for medicine, 23 types are considered as homologous plants of medicine and food by the Tujia people in Laifeng, or as part of a tonic diet. These plants are typically used for stewing with meat, bones, and other foods, playing a role in tonifying deficiency, strengthening muscles and bones, and enhancing eyesight. Stewing is the preferred method of consumption for its health benefits, a conclusion that aligns with research findings in other regions [49, 58]. It is worth mentioning that the potential toxicity of WEPs also needs to be taken seriously. Studies have shown that certain types of WEPs contain oxalates and other potentially toxic compounds, which often exert toxic effects on the human body [59, 60]. The fruit of Illicium henryi is documented in the Flora of China as highly toxic. However, during the investigation, it was found that the Tujia ethnic group in Laifeng use their fruits as spices, and their consumption knowledge deserves further research. In addition, further toxicology research on WEPs should be conducted to identify specific toxic components and ensure consumer safety.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 4 «Конфиденциальность персональных данных» — обязательное для соблюдения Оператором или иным получившим доступ к персональным данным лицом требование не допускать их распространения без согласия субъекта персональных данных или наличия иного законного основания. 1. 1. 5 «Пользователь сайта (далее Пользователь, Субъект персональных данных)» — лицо, имеющее доступ к сайту, посредством сети Интернет и использующее сайт. 1. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: ResultsCircadian analysis of canonical clock genes in the liver after exposure to simulated shift- work light conditionsTo investigate the impact of shift-work light conditions on the liver clock, we examined the circadian rhythms of canonical clock genes (Arntl, Npas2, Per1, Per2, Per3, Cry1, Cry2, and Dbp) in the liver samples of mice exposed to simulated shift-work light conditions. Rhythmic gene expression and its significance was determined at p < 0. 05 of CircaCompare. Our findings revealed significant rhythmic patterns in all analyzed clock genes, both in the control group and in the mice exposed to the simulated shift-work light conditions. However, Cry1 did not show significant rhythmicity in the long-term rotating shift scenario and Cry2 did not exhibit significant rhythmicity in the chronic jet-lag scenario (Figure 2, Table 154). This suggests that these genes may be more sensitive to prolonged disruption of light-dark cycles. Furthermore, we examined various circadian properties such as phase, amplitude, and MESOR and compared differences between conditions (Figures 2 and 4A, Table 154). In the short-term rotating shift and chronic jet-lag scenarios, we did not observe any discernible phase differences compared to the control condition. However, in the long-term rotating shift scenario, significant phase advance of at least four hours were detected in five out of eight clock genes: Npas2, Per1, Per2, Per3, and Cry2. Regarding amplitude, we did not find significant differences in the rotating shift conditions. However, we did observe a significant decrease in amplitude of Per1 and Dbp among mice exposed to chronic jet-lag compared to the control group. This indicates that chronic disruption of light-dark cycles may affect the robustness of circadian rhythms in these genes. We did not find any significant changes in MESOR with short-term rotating shift. However, we observed a significant increase in MESOR with the genes Arntl, Per2, Per3, and Cry2 in the long-term rotating shift condition. Conversely, we found a significant decrease in MESOR with the genes Per1 and Dbp in the chronic jet-lag scenario. Overall, these results suggest that the circadian clock in the liver is highly impacted in mice exposed to the long-term rotating shift condition with a clear but less dramatic impact in mice exposed to chronic jet-lag.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Protection and utilization of WEPs of the Tujia ethnic group in LaifengThe mastery of knowledge about WEPs by informants is significantly positively correlated with their age, implying that older informants possess more extensive knowledge [16]. With the development of the economy and society, the continuous trend of migrant workers has led to a high degree of hollowing out and aging within rural communities [61]. The majority of residents in the surveyed villages are elderly, with 68. 7% of the respondents being over 60 years old. Similar to most local residents in the region, the traditional knowledge of using WEPs among the Tujia ethnic group in Laifeng is mainly transmitted orally [62]. However, the knowledge is fading away due to the aging of the informants, raising the possibility that no one with inherit it. Due to the improvement of living standards, an increasing number of local residents, especially the younger generation, opt to cultivate a single species or purchase food to fulfill their daily consumption needs, thereby presenting a challenge to the traditional utilization knowledge of WEPs. In addition, factors such as climate change, land use changes, and the impact of human activities on the environment pose a serious threat to the habitat of WEPs. Concurrently, with the increasing emphasis placed on health preservation and dietary diversity by modern individuals, the opportunities for the development and utilization of WEPs have also increased. Through the application of modern food science methods to analyze the nutritional components, medicinal value, and functions of WEPs, the scientific validity of traditional knowledge of using WEPs is examined, thereby providing a foundation for their development and utilization. The nutritional, phytochemical, and pharmacological studies of some representative WEPs of the Tujia ethnic group in Laifeng have demonstrated the rationality of local people’s use of WEPs and revealed their potential development and utilization value. The fruits of Elaeagnus sp. are rich in nutrients such as VC, VB1, phosphorus, and calcium, making them very suitable for processing and making fruit juice, fruit wine, and other products [63]. The main nutritional components of Castanea henryi are starch, sugars, and being rich in protein, fat, fiber, vitamin C, and mineral elements [64].

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 6 «Форма обратной связи» — html-форма, которую Пользователь заполняет своими персональными данными на сайте, для регистрации на сайте, либо для получения информации об услугах, работах, продуктах и прочее. 1. 1. 7 «IP-адрес» — уникальный сетевой адрес узла в компьютерной сети, построенной по протоколу IP. 1. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Four genes (Arntl, Per2, Per3, and Dbp) exhibited significant phase differences following the long-term rotating shift condition, and one gene (Arntl) showed a significant phase difference following chronic jet-lag. Notably, most of these genes displayed a phase advance following simulated shift-work conditions compared to the control group. Arntl consistently exhibited dysregulation across all simulated shift conditions, particularly showing a phase delay in the long-term rotating shift scenario. Moreover, we observed alterations in amplitude: Cry2 and Arntl exhibited reduced amplitude following short-term and long-term rotating shift conditions, respectively. Per2 displayed reduced amplitude in both rotating shift conditions, while no significant differences in amplitude were noted with chronic jet-lag. two out of eight genes analyzed in each shift condition exhibited MESOR differences compared to the control group. Arntl displayed a significant increase in MESOR following exposure to short-term rotating shift and chronic jet-lag conditions, while Per1 showed a significant increase following long-term rotating shift and chronic jet-lag. Additionally, Cry2 and Per2 exhibited a significant decrease in MESOR following exposure to the short-term and long-term rotating shift conditions, respectively. Overall, these results indicate that the circadian clock in the skin is impacted by all three simulated shift conditions and suggest that the skin clock is more sensitive to shift-work light conditions compared to the liver clock. Similar to our observations in the liver, the circadian clock in the skin is highly impacted in mice exposed to long-term rotating shift conditions. Figure 3. Circadian rhythms of canonical clock genes in the skin following exposure to simulated shift-work light conditions. The graphs in the figure illustrate the 24-hour expression (Mean ± SE) of Arntl, Npas2, Per1, Per2, Per3, Cry1, Cry2, and Dbp in the skin under constant darkness following exposure to simulated shift-work light conditions. The figure enables a comparison between the control group and three experimental conditions: short-term rotating shift (left), long-term rotating shift (middle), and control vs chronic jet-lag (right) were represented in the figure. To ensure precise analysis, the mRNA expression throughout the entire time course was normalized against the geometric mean expression of housekeeping genes Actb and Ppib.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: The fruit of Pyracantha fortuneana is rich in various vitamins, amino acids, anthocyanins, polysaccharides, and flavonoids, which have good in vitro antioxidant, antibacterial, whitening, lipid-lowering, blood coagulation promoting, antiaging, anti-inflammatory, and other effects [65]. Indeed, some species of WEPs of the Tujia ethnic group in Laifeng have also been developed into healthy, ecological products, contributing to the local economy, such as Nekemias grossedentata, Rosa roxburghii f. normalis, and Litsea mollis. Combining the development of WEPs with local industries is a beneficial strategy to address the challenges of hollowing out local villages and aging populations [66]. Furthermore, the local homegarden management plays a protective role for WEPs, with the homegarden serving as an important gene pool for WEPs [54, 67]. In the survey, it was found that some WEPs were introduced and cultivated by the Tujia ethnic group in Laifeng from the wild in their own homegardens for ornamental, edible, and medicinal purposes, such as Taxus wallichiana var. mairei, Caragana sinica, and Diuranthera major. In addition, Polygonatum sibiricum is widely planted in the homegardens of the Tujia ethnic group in Laifeng due to its economic value. This practice, to some extent, protects the distribution and sustainable utilization of WEPs, while also making the homegardens of the Tujia ethnic group in Laifeng full of wildness and beautifying the living environment. Meanwhile, it is worth further studying how homegarden management affects WEPs in the future. ConclusionThe study conducted an ethnobotanical survey of WEPs across 26 villages in Laifeng, recording 163 species of WEPs from 64 families and 118 genera, along with corresponding traditional knowledge from the Tujia ethnic group in Laifeng. The traditional utilization of WEPs by the Tujia ethnic group in Laifeng is rich in knowledge, with local individuals displaying unique and rich insights into the collection, processing, and consumption of WEPs, which has become a part of the local food culture.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 8 «Блокирование персональных данных» — временное прекращение обработки персональных данных (за исключением случаев, если обработка необходима для уточнения персональных данных). 1. 1. 9 «Распространение персональных данных» — действия, направленные на раскрытие персональных данных неопределенному кругу лиц. 1. 1. 10 «Предоставление персональных данных» — действия, направленные на раскрытие персональных данных определенному лицу или определенному кругу лиц. 1. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: The statistical significance of the circadian rhythms and the variations in circadian characteristics between the control group and the simulated shift-work conditions were evaluated using CircaCompare, with a significance level set at p < 0. 05. In the figure, genes that exhibit a significant rhythmic pattern are depicted by continuous lines, while genes lack a rhythmic pattern are represented by dotted lines. Figure 4. Differential circadian properties of canonical clock genes in the liver and skin following exposure to simulated shift-work light conditions. The figure represents differences in phase (left), amplitude (middle), and MESOR (right) of canonical clock genes in the liver (top) and skin (bottom) of mice subjected to short-term, long-term rotating shift, and chronic jet-lag conditions, in comparison to a control condition. Significance testing was performed using CircaCompare with a threshold of p < 0. 05, and the corresponding p-values can be found in Table 1. 54DiscussionOur study aimed to fill a significant knowledge gap regarding the effects of different durations and types of shift conditions on the circadian system. Shift-work has been hypothesized to disrupt the synchronization between the central and peripheral circadian machinery. 36 Previous studies in humans have only examined the impact of mistimed sleep on molecular rhythms for about a week,6–8 limiting our understanding of the long-term consequences. We conducted a study using a well-established C57BL/6J mouse model to investigate the consequences of various durations and types of shift-work light conditions on the circadian system. By simulating shift-work light conditions, we were able to observe changes in the circadian expression of canonical clock genes in both the liver and the skin. Light is widely recognized as the primary synchronizer for maintaining the mammalian circadian system. Two photoreceptors, melanopsin (OPN4) and neuropsin (OPN5), have been identified as mediators of light entrainment from the retinal ganglion cells to the suprachiasmatic nucleus (SCN),37,38 which serves as the central pacemaker of the circadian system. Interestingly, recent studies have shown that OPN5 in murine melanocytes is involved in circadian photoentrainment and the expression of clock genes, a phenomenon not observed in the liver. 39 On the other hand, the liver, being a metabolically active organ, can directly entrain its clock through feeding-fasting cycles.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Türk Doğa ve Araştırma ütüphaneme Ekle × Araştırma Oluştur öster Research on for in Bigadiç (Balıkesir-Turkey) Yıl 2022, Cilt: 11 Sayı: 4, 142 - 147, 28. 12. 2022 Gökhan Tanaydın Fatih Satıl Uğur Çakılcıoğlu Cited By: 1 Öz In this study, the ethnobotanical properties of the plants used by the local people for food in Bigadiç province were investigated. The study was carried out in fifteen rural neighborhoods and two district markets. A total of 104 resource persons, 76 men and 28 women, were interviewed. These plants, which are used among the people, were also identified and collected in their natural environments and their herbariums were made. As a result of the research, it was determined that a total of 51 taxa belonging to 26 families in the region were used for food purposes. The first five families of plants used as food are as follows: Rosaceae (18%), Lamiaceae (12%), Cucurbitaceae (7%), Fabaceae (7%), Moraceae (7%) and others (%41). The first five genera, which are most commonly used by the public, are listed as follows: Triticum (21), Sesamum (19), Origanum (17), Portulaca (14) and Vitis (14). Mostly fruit/seed (32), leaf (17) and root/stem (3) parts of these plants are used by the public. In the study, the plants that people use as food mostly; eating in the kitchen (22), fruit and fruit juice (21), spice (7), medicinal tea (5), oil (4) and molasses/jam (3). As a result of the study, more diversity was observed in the use of wild plants as food, especially in rural. Balıkesir, Bigadiç, Ethnobotany, Food plants, Traditional use Kaynakça [1]. 2 and COVID 19: The most important research questions. Cell Biosci. 2020;10:1-5. [2] Kawarty AMAM. , Behçet L, Çakılcıoğlu U.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 11 «Трансграничная передача персональных данных» — передача персональных данных на территорию иностранного государства органу власти иностранного государства, иностранному физическому лицу или иностранному юридическому лицу. 2. ОБЩИЕ ПОЛОЖЕНИЯ 2.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 40–42 Prior research has demonstrated this ability, indicating that the liver is more influenced by metabolic cues compared to the skin. Therefore, in the current study, we examined the impact of simulated shift-work light conditions on the circadian gene expression of canonical clock genes in two different tissues: the liver and the skin. Unlike the skin, which directly senses external light stimuli,39 the entrainment of liver clocks by light serves as a secondary event. In addition to synchronization from the central clock, feeding has been well demonstrated as a mechanism to reset liver clocks. 40–42 In our study, we provided mice with unrestricted access to food, allowing us to primarily observe changes arising from shift-work light conditions. The data from our study indicated that short-term exposure to rotating shift-light conditions did not significantly affect the circadian rhythms of liver clock genes. However, long-term exposure to rotating shifts resulted in circadian dysregulation, as evidence by loss of rhythmicity or significant differences in phase, amplitude, or MESOR in 7 out of 8 tested clock genes, and the jet-lag condition affected 3 out of 8 of the genes tested. These results suggest that liver clocks exhibit adaptability under less aggressive shift-work light conditions, possibly due to input from multiple environmental cues. Moreover, recent research has demonstrated that restricted feeding not only entrains liver clocks but also influences skin clocks in a distinct manner, highlighting an interesting interplay wherein a single stimulus can impact multiple systems. 31In our investigation, we observed significant disturbances in the circadian rhythm of canonical clock genes in the skin under various shift-work light conditions. Short-term exposure to rotating shift schedules and chronic jet-lag led to the disruption of circadian rhythmicity in 4 out of 8 tested canonical clock genes, while long-term exposure to rotating shifts affected 6 out of 8 of the genes, with most of these changes attributed to phase differences. Notably, unlike the liver, the circadian clock in the skin exhibited significant dysregulation across all shift-work light conditions examined in our study. This suggests that the skin’s circadian clock is more susceptible to the impact of shift-work light conditions compared to the clock in the liver. One potential explanation for this susceptibility is the involvement of opsins-mediated signaling. Opsins are a class of light sensing G protein-coupled receptors that trigger signaling cascades upon photosensation.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Traditional information on wild food crops of Ballakaati (Erbil-Northern Iraq). . 2021;21(3):520-531. [3]. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J Ethnopharmacol. 2011;137(1):469-486. [4] Kayabaşı Poyraz, N, Tümen G, Polat R. Ethnobotanical studies on useful plants in Manyas (Balıkesir/ Turkey) region. Conser. 2016;9(3):58-63. [5] Polat R, Cakilcioglu U, Satıl F. Traditional uses of medicinal plants in Solhan (Bingöl-Turkey). J Ethnopharmacol. 2013;148(3):951-963. [6] Sağıroğlu M, Arslantürk. (An ethnobotanical survey from Hayrat (Trabzon) and Kalkandere (Rize/ Turkey). Conser. 2012;5(1):31-43. [7] Satıl F, Tümen G, Dirmenci T, Çelik A, Arı Y, Malyer H. Balıkesir Study in and Around Kazdağı 2004-2006. TÜBA-. 2007;(5):171-199. [8] Selvi S, Polat R, Çakılcıoğlu ğ ZF. An ethnobotanical review on medicinal plants of the Lamiaceae family in Turkey. Bot. 2022;46(4):283-332. [9] Yalçın S, Akan H. Çakılcıoğlu U. Traditional uses of some medicinal plants in Suruç (Şanlıurfa-Turkey). Nature Sci. 2021;10(1):236-244. [10] Selvi S, Satıl F, Polat R, Çakılcıoğlu U. A research on medicinal plants collected from Kazdağları (Balıkesir-Edremit) and sold in herbalists in the region, Kazdağları III. National Symposium. 2012;24(26):505-513. [11] Ertug F.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Акцепт Пользователем оферты на сайте означает согласие Пользователя на обработку персональных данных, а также согласие с настоящей Политикой конфиденциальности и условиями обработки персональных данных Пользователя, а также на трансграничную передачу. Оформление отдельного согласия на обработку персональных данных Пользователя не требуется. 2.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Previous studies have identified the expression of various opsins in different models, including murine melanocytes,39 human melanocytes, keratinocytes, and dermal fibroblasts, and hair follicle stem cells. 43 The presence of opsins within the skin cells indicates the possibility of light-sensing capabilities in the skin tissue and the potential influence of environmental light cues on core clock regulation. However, experimental verification of this hypothesis is still required. At the level of independent clock genes, we found that the circadian rhythms of cryptochrome genes (Cry1 and/or Cry2), which are the primary repressors of the molecular clock and also involved in maintaining genome integrity of cells,44,45 were significantly disrupted under simulated shift conditions in both tissues. However, in the case of short-term rotating shift specifically affecting the liver, the rhythmicity of these genes remained intact. Cryptochromes (CRYs), found across various species from plants to animals, conserved evolutionarily, function in photoreception and signal transduction. 46 Their precise roles in mammalian circadian rhythm and light perception are complex, yet evidence suggests that CRYs may act as circadian photopigments, a possibility supported by experiments involving vitamin A depletion and mutations. 47,48 Our findings align with this research, indicating that Cry genes could be more sensitive to altered light shifts than other clock genes. Consequently, their rhythms may be uniquely susceptible to disruption under simulated shift conditions. Moreover, our findings are consistent with existing literature in humans, which has associated disrupted rhythms of Cry1 and Cry2 with circadian dysregulation of DNA repair and increased DNA damage following exposure to simulated night shift conditions. 49 Additionally, we observed consistent dysregulation of the circadian transcription factor Arntl, which is involved in protecting skin cells and regulating UVB associated DNA repair response and melanin pigmentation. 23,50,51 This dysregulation occurred following exposure to all different types of simulated shift-work light conditions utilized in this study. Our study has few limitations that should be considered when interpreting the findings. First, the use of a mouse model may limit the generalizability of the results to humans. Second, the simulation of shift-work light conditions may not fully capture the complexity of real-world shift schedules. Third, we only studied male mice under these conditions, and outcomes could be different for female mice. Fourth, the sample size was relatively small, potentially affecting the statistical power.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Contemporary plant Gathering in Central Anatolia: and ethnobotanical study. In this work: Öztürk, M. , Seçmen, Ö. , Görk G. (edlr. ). Proceedings of the 4. in Symposium, 945-962, Izmir; Press; 1996. [12] Koçyiğit M. An ethnobotanical research in Yalova province. Institute of Health Sciences, Master Thesis. Istanbul; 2005. [13] Yücel E, Güney F, Şengün İY. Wild plants consumed as food in Mihalıççık district, Eskişehir/Turkey, and consumption patterns of these plants. Conser. 2010;(3):158-175. [14] Aktan T, Altan Y. Natural ornamental plants of new City (Bursa) cemeteries. Univ. J Sci. 2011;7(2):31-39. [15] Ekren E, Chorbaci OL. A study on ethnobotanical uses: the example of Rize urban open green spaces. J of Animal Sci. 2021;6(4):487-497. [16] Kincal S, Ceylan O, Görk G. Ethnobotanical features of Ula (Mugla/ Turkey) district. Conser. 2021;14(1):69-81. [17] Korkmaz M, Karakurt E. Traditional uses of natural food plants in Kelkit (Gümüşhane) district. J Res. 2015;8(2):31-39. [18] Onar S. Ethnobotany of Bandırma (A1 (A) Balıkesir) and its surroundings, Master Thesis, Çanakkale Çanakkale; 2006. [19] Polat R, Satıl F. Balıkesir ethnobotanical studies in Havran and Burhaniye. TÜBA-KED of Cult Invent. 2010:8:65-100. [20] Nath EO. Natural dye plants in Kepsut (Balıkesir, Turkey). Biol. 2015;74(2):25-32.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 В случае несогласия с условиями Политики конфиденциальности Пользователь должен прекратить использование сайта. 2. 3 Настоящая Политика конфиденциальности применяется только к сайту Оператор не контролирует и не несет ответственность за сайты третьих лиц, на которые Пользователь может перейти по ссылкам, доступным на сайте. 2. 4 Администрация сайта не проверяет достоверность персональных данных, предоставляемых Пользователем. 3.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Lastly, the duration of exposure in our study may not fully reflect the long-term consequences of shift-work in humans. Despite these limitations, our study highlights the heightened susceptibility of the skin to circadian misalignment under shift-work light conditions, in comparison to the liver. Furthermore, we emphasize the significance of tissue-specific responses and the role of light regulating circadian rhythms, specifically focusing on canonical clock genes during shift-work. While many rodent studies employ jet-lag as an analog for shift-work, in our study, we used a rotating shift model, which is more reflective of actual shift-work conditions and offers different results than the jet-lag model. Our findings emphasize the necessity of recognizing and addressing the distinct impacts of various light conditions in circadian research. These findings offer valuable insights that can guide future research, potentially leading to the discovery of novel mechanisms and more effective treatment strategies for shift-work associated diseases. Author contributionsBala S. C. Koritala: Conceptualization, Data curation, Formal analysis, – original draft preparation, Writing – review & editing. Panshak P. Dakup: – original draft preparation, Writing – review & editing. Kenneth I. Porter: Investigation, Methodology, Resources, Validation, Writing – review & editing. Shobhan Gaddameedhi: Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing. Data availabilityUnderlying datafigshare: Raw data files with replicates titled as “Cycle threshold values of qPCR data for genes in the liver and skin of animals that were exposed to both control and simulated shift conditions”. 53 Extended datafigshare: Table 1. CircaCompare analysis of canonical clock genes in the mouse liver and skin following exposure to simulated shift-work light conditions. 54 Data are available under the terms of the Attribution 4. 0 International license (CC-BY 4. 0). Reporting guidelinesfigshare: checklist for ‘The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study’. 55 1. : Entrainment of the human circadian clock to the natural light-dark cycle. Curr. Biol. 2013 Aug 19; 23(16): 1554–1558. Pub| Text | Text 2.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: [21] Alkac, S. Some plants with economic importance and ethnobotanical features in the Bigadiç District of Alaçam Mountains (Balıkesir), Balıkesir Univ, Inst Sci, Department of Biology, Master's Thesis; 2013. [22] Satıl F, Akçiçek E, Selvi S. An ethnobotanical study in and around (Balıkesir/İzmir). Biol Sci. 2008;1:31-36. [23] Duran A, Satıl F, Tumen G. Wild fruits eaten in Balıkesir region and their ethnobotanical properties. J Bot. 2001;8:87-94. [24] İnci Aladı H, Satil F, Selvi S. Wild fruits left in the public bazaars of (Balıkesir) and their medicinal uses. Conser. 2019;12(1):89-99. [25] Davis, PH. Flora of Turkey and the Islands. Vol. 1-9. Edinburgh: Press: 1965-1985. [26] Güner A, Özhatay N, Ekim T, Başer KHC Flora of Turkey and the Islands. Vol. 11. Edinburgh; Press; 2000. [27] Nath EO, Kultur S. Natural dye plants in Savaştepe (Balıkesir, Turkey). J Istanbul Univ. 2016;46(2):89-95. Research on for in Bigadiç (Balıkesir-Turkey) Yıl 2022, Cilt: 11 Sayı: 4, 142 - 147, 28. 12. 2022 Gökhan Tanaydın Fatih Satıl Uğur Çakılcıoğlu Cited By: 1 Öz In this study, the ethnobotanical properties of the plants used by the local people for food in Bigadiç province were investigated. The study was carried out in fifteen rural neighborhoods and two district markets. A total of 104 resource persons, 76 men and 28 women, were interviewed. These plants, which are used among the people, were also identified and collected in their natural environments and their herbariums were made.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: ПРЕДМЕТ ПОЛИТИКИ КОНФИДЕНЦИАЛЬНОСТИ 3. 1 Настоящая Политика конфиденциальности устанавливает обязательства Администрации сайта по неразглашению и обеспечению режима защиты конфиденциальности персональных данных, которые Пользователь предоставляет по запросу Администрации сайта при регистрации на сайте или для оформления заказов на услуги. 3.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Roenneberg T, Merrow M: Clock and Human Health. Curr. Biol. 2016 May 23; 26(10): R432–R443. Pub| Text 3. Costa G: Shift work and health: current problems and preventive actions. Saf. Health Work. 2010 Dec; 1(2): 112–123. Pub| Text | Text 4. : Health consequences of electric lighting practices in the modern world: A report on the Program’s workshop on shift work at night, artificial light at night, and circadian disruption. Sci. Total Environ. 2017 Dec 31; 607-608: 1073–1084. Pub| Text | Text 5. : Shift Work: Rhythms and Sleep-Implications for Health and Well-Being. Curr. Sleep Med. Rep. 2017 Jun; 3(2): 104–112. Pub| Text | Text 6. : Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome. Proc. Natl. Acad. Sci. U. S. A. 2018 May 22; 115(21): 5540–5545. Pub| Text | Text 7. : Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLoS Biol. 2019 Jun; 17(6): e3000303. Epub 2019/06/19. Pub| Text | Text 8. : Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism. Proc. Natl. Acad. Sci. U. S. A. 2018 Jul 24; 115(30): 7825–7830. Pub| Text | Text 9. Adams KL, Castanon-Cervantes O, Evans JA, et al. : Environmental circadian disruption elevates the IL-6 response to lipopolysaccharide in blood. J. Biol. Rhythm. 2013 Aug; 28(4): 272–277. Pub| Text | Text 10. : G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biol. 2019 Apr; 17(4): e3000228. Epub 2019/05/01. Pub| Text | Text 11.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: As a result of the research, it was determined that a total of 51 taxa belonging to 26 families in the region were used for food purposes. The first five families of plants used as food are as follows: Rosaceae (18%), Lamiaceae (12%), Cucurbitaceae (7%), Fabaceae (7%), Moraceae (7%) and others (%41). The first five genera, which are most commonly used by the public, are listed as follows: Triticum (21), Sesamum (19), Origanum (17), Portulaca (14) and Vitis (14). Mostly fruit/seed (32), leaf (17) and root/stem (3) parts of these plants are used by the public. In the study, the plants that people use as food mostly; eating in the kitchen (22), fruit and fruit juice (21), spice (7), medicinal tea (5), oil (4) and molasses/jam (3). As a result of the study, more diversity was observed in the use of wild plants as food, especially in rural. Balıkesir, Bigadiç, Ethnobotany, Food plants, Traditional use Kaynakça [1]. 2 and COVID 19: The most important research questions. Cell Biosci. 2020;10:1-5. [2] Kawarty AMAM. , Behçet L, Çakılcıoğlu U. Traditional information on wild food crops of Ballakaati (Erbil-Northern Iraq). . 2021;21(3):520-531. [3]. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J Ethnopharmacol. 2011;137(1):469-486. [4] Kayabaşı Poyraz, N, Tümen G, Polat R. Ethnobotanical studies on useful plants in Manyas (Balıkesir/ Turkey) region. Conser. 2016;9(3):58-63. [5] Polat R, Cakilcioglu U, Satıl F. Traditional uses of medicinal plants in Solhan (Bingöl-Turkey). J Ethnopharmacol. 2013;148(3):951-963. [6] Sağıroğlu M, Arslantürk.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Персональные данные, разрешённые к обработке в рамках настоящей Политики конфиденциальности, предоставляются Пользователем путём заполнения формы на сайте в соответствующих разделах и включают в себя следующую информацию: 3. 2. 1 фамилию, имя, отчество Пользователя; 3. 2. 2 адрес электронной почты (e-mail); 3. 2. 3 место жительство Пользователя; 3. 2. 4 платежные реквизиты Пользователя; 3. 2. 5 домашний, рабочий, мобильный телефоны. 3.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: : Circadian and behavioural responses to shift work-like schedules of light/dark in the mouse. J. Mol. Psychiatry. 2013; 1(1): 7. Epub 2013/01/01. Pub| Text | Text 12. van Oostrom CT et al. : in Mice. Curr. Biol. 2015 Jul 20; 25(14): 1932–1937. Pub| Text 13. Davidson AJ, Castanon-Cervantes O, Leise TL, et al. : Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system. Eur. J. Neurosci. 2009 Jan; 29(1): 171–180. Pub| Text 14. : Light-and Lesion Phenotypes. J. Am. Heart Assoc. 2021 Jan 19; 10(2): e018151. Epub 2021/01/07. Pub| Text | Text 15. :. Cell Metab. 2016 Aug 9; 24(2): 324–331. Pub| Text | Text 16. : Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One. 2010 Jun 7; 5(6): e10995. Epub 2010/06/12. Pub| Text | Text 17. : of Suppresses Hepatocarcinogenesis. Cancer Cell. 2016 Dec 12; 30(6): 909–924. Pub| Text | Text 18. : Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci. Adv. 2020 Oct; 6(42). Epub 2020/10/16. Pub| Text | Text 19. : Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014 Oct 23; 159(3): 514–529. Pub| Text 20. : Glucose tolerance in mice exposed to light-dark stimulus patterns mirroring dayshift and rotating shift schedules. Sci. Rep. 2017 Jan 12; 7: 40661. Epub 2017/01/13. Pub| Text | Text 21. : A rotating light cycle promotes weight gain and hepatic lipid storage in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2018 Dec 1; 315(6): G932–G942. Pub| Text 22.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: (An ethnobotanical survey from Hayrat (Trabzon) and Kalkandere (Rize/ Turkey). Conser. 2012;5(1):31-43. [7] Satıl F, Tümen G, Dirmenci T, Çelik A, Arı Y, Malyer H. Balıkesir Study in and Around Kazdağı 2004-2006. TÜBA-. 2007;(5):171-199. [8] Selvi S, Polat R, Çakılcıoğlu ğ ZF. An ethnobotanical review on medicinal plants of the Lamiaceae family in Turkey. Bot. 2022;46(4):283-332. [9] Yalçın S, Akan H. Çakılcıoğlu U. Traditional uses of some medicinal plants in Suruç (Şanlıurfa-Turkey). Nature Sci. 2021;10(1):236-244. [10] Selvi S, Satıl F, Polat R, Çakılcıoğlu U. A research on medicinal plants collected from Kazdağları (Balıkesir-Edremit) and sold in herbalists in the region, Kazdağları III. National Symposium. 2012;24(26):505-513. [11] Ertug F. Contemporary plant Gathering in Central Anatolia: and ethnobotanical study. In this work: Öztürk, M. , Seçmen, Ö. , Görk G. (edlr. ). Proceedings of the 4. in Symposium, 945-962, Izmir; Press; 1996. [12] Koçyiğit M. An ethnobotanical research in Yalova province. Institute of Health Sciences, Master Thesis. Istanbul; 2005. [13] Yücel E, Güney F, Şengün İY. Wild plants consumed as food in Mihalıççık district, Eskişehir/Turkey, and consumption patterns of these plants. Conser. 2010;(3):158-175. [14] Aktan T, Altan Y.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 Администрация сайта осуществляет сбор статистики об IP-адресах своих посетителей. Данная информация используется с целью выявления и решения технических проблем. 3. 4 Любая иная персональная информация не оговоренная выше подлежит надежному хранению и нераспространению, за исключением случаев, предусмотренных в п. п. 5. 2. и 5. 3. настоящей Политики конфиденциальности. 4. ЦЕЛИ СБОРА ПЕРСОНАЛЬНОЙ ИНФОРМАЦИИ ПОЛЬЗОВАТЕЛЯ 4.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2020 Sep; 36(5): 329–338. Pub| Text | Text 44. : DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. elife. 2015 Mar 10; 4. Epub 20150310. Pub| Text | Text 45. : Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes Dev. 2014 Sep 15; 28(18): 1989–1998. Pub| Text | Text 46. Sancar A: Regulation of the mammalian circadian clock by cryptochrome. J. Biol. Chem. 2004 Aug 13; 279(33): 34079–34082. Pub| Text 47. : Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 11708–11713. Pub| Text | Text 48. : Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J. Biol. Rhythms. 2004; 19: 504–517. Pub| Text 49. : Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans. J. Pineal Res. 2021 Apr; 70(3): e12726. Epub 20210314. Pub| Text | Text 50. : Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc. Natl. Acad. Sci. U. S. A. 2012 Jul 17; 109(29): 11758–11763. Pub| Text | Text 51. : Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells. Melanoma Res. 2021 Sep; 34(5): 955–965. Pub| Text | Text 52. : Determination of reference genes for circadian studies in different tissues and mouse strains. BMC Mol. Biol. 2010 Aug 16; 11: 60. Pub| Text | Text 53. : Cycle threshold values of qPCR data for genes in the liver and skin of animals that were exposed to both control and simulated shift conditions. [Dataset]. figshare. 2023. Text 54.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Natural ornamental plants of new City (Bursa) cemeteries. Univ. J Sci. 2011;7(2):31-39. [15] Ekren E, Chorbaci OL. A study on ethnobotanical uses: the example of Rize urban open green spaces. J of Animal Sci. 2021;6(4):487-497. [16] Kincal S, Ceylan O, Görk G. Ethnobotanical features of Ula (Mugla/ Turkey) district. Conser. 2021;14(1):69-81. [17] Korkmaz M, Karakurt E. Traditional uses of natural food plants in Kelkit (Gümüşhane) district. J Res. 2015;8(2):31-39. [18] Onar S. Ethnobotany of Bandırma (A1 (A) Balıkesir) and its surroundings, Master Thesis, Çanakkale Çanakkale; 2006. [19] Polat R, Satıl F. Balıkesir ethnobotanical studies in Havran and Burhaniye. TÜBA-KED of Cult Invent. 2010:8:65-100. [20] Nath EO. Natural dye plants in Kepsut (Balıkesir, Turkey). Biol. 2015;74(2):25-32. [21] Alkac, S. Some plants with economic importance and ethnobotanical features in the Bigadiç District of Alaçam Mountains (Balıkesir), Balıkesir Univ, Inst Sci, Department of Biology, Master's Thesis; 2013. [22] Satıl F, Akçiçek E, Selvi S. An ethnobotanical study in and around (Balıkesir/İzmir). Biol Sci. 2008;1:31-36. [23] Duran A, Satıl F, Tumen G. Wild fruits eaten in Balıkesir region and their ethnobotanical properties. J Bot. 2001;8:87-94. [24] İnci Aladı H, Satil F, Selvi S.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Персональные данные Пользователя Администрация сайта может использовать в целях: 4. 1. 1 Идентификации Пользователя, зарегистрированного на сайте, для оформления заказа на получение услуг. 4. 1. 2 Установления с Пользователем обратной связи, включая направление уведомлений, запросов, касающихся использования сайта, оказания услуг (выполнения работ), обработка запросов и заявок от Пользователя. 4. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: : CircaCompare analysis of canonical clock genes in the mouse liver and skin following exposure to simulated shift-work light conditions. [Dataset]. figshare. 2023. Text 55. : - F1000 Research. pdf. figshare. 2023. on this 10. 12688/f1000research. 136998. 3 version 2 Revised Published: 02 Aug 2023, 12:762 version 1 Published: 28 Jun 2023, 12:762 Copyright © 2023 Koritala BSC et al. This is an open access 10. 12688/f1000research. 136998. 3) NOTE: it is important to ensure the information in square brackets after the title is included in all 10. 5256/f1000research. 154609. r197687) The direct URL for this report is: I approve of all changes. . . Continue reading approve of all changes made to the revised manuscript. Competing Interests: No competing interests were disclosed. Reviewer Expertise: circadian rhythms, cancer I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: The direct URL for this report is: Authors have. . . Continue reading have responded my comments. Competing Interests: No competing interests were disclosed. Reviewer Expertise: Circadian clock and metabolism I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: The direct URL for this report is: In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal. . .

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Wild fruits left in the public bazaars of (Balıkesir) and their medicinal uses. Conser. 2019;12(1):89-99. [25] Davis, PH. Flora of Turkey and the Islands. Vol. 1-9. Edinburgh: Press: 1965-1985. [26] Güner A, Özhatay N, Ekim T, Başer KHC Flora of Turkey and the Islands. Vol. 11. Edinburgh; Press; 2000. [27] Nath EO, Kultur S. Natural dye plants in Savaştepe (Balıkesir, Turkey). J Istanbul Univ. 2016;46(2):89-95. Tüm Kaynakçayı Göster Kaynakça Göster Toplam 27 adet kaynakça vardır. Ayrıntılar Türkçe Bölüm Gökhan Tanaydın 0000-0002-7222-1270 Türkiye Fatih Satıl 0000-0002-4938-1161 Türkiye Uğur Çakılcıoğlu Genç MYO 0000-0002-3627-3604 Türkiye Yayımlanma Tarihi 28 Aralık 2022 Yayımlandığı Sayı Yıl 2022 Cilt: 11 Sayı: 4 Kaynak Göster APA Tanaydın, G. , Satıl, F. , & Çakılcıoğlu, U. (2022). Research on for in Bigadiç (Balıkesir-Turkey). Türk Doğa Dergisi, 11(4), 142-147. AMA Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. Aralık 2022;11(4):142-147. doi:10. 46810/tdfd. 1172635 Chicago Tanaydın, Gökhan, Fatih Satıl, ve Uğur Çakılcıoğlu. “Research on for in Bigadiç (Balıkesir-Turkey)”.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 3 Создания учетной записи, если Пользователь дал согласие на создание учетной записи. 4. 1. 4 Обработки и получения платежей, оспаривания платежа. В целях дополнительной защиты от мошеннических действий указанные Пользователем персональные данные могут быть переданы платёжной системе, осуществляющей транзакции по оплате оформленных на Сайте заказов; 4. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Continue reading “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Is the work clearly and accurately presented and does it cite the current literature?

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Türk Doğa Dergisi 11, sy. 4 (Aralık 2022): 142-47. EndNote Tanaydın G, Satıl F, Çakılcıoğlu U (01 Aralık 2022) Research on for in Bigadiç (Balıkesir-Turkey). Türk Doğa ve 11 4 142–147. IEEE G. Tanaydın, F. Satıl, ve U. Çakılcıoğlu, “Research on for in Bigadiç (Balıkesir-Turkey)”, TDFD, c. 11, sy. 4, ss. 142–147, 2022, doi: 10. 46810/tdfd. 1172635. ın, Gökhan vd. “Research on for in Bigadiç (Balıkesir-Turkey)”. Türk Doğa ve 11/4 (Aralık 2022), 142-147. JAMA Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. 2022;11:142–147. MLA Tanaydın, Gökhan vd. “Research on for in Bigadiç (Balıkesir-Turkey)”. Türk Doğa Dergisi, c. 11, sy. 4, 2022, ss. 142-7, doi:10. 46810/tdfd. 1172635. Vancouver Tanaydın G, Satıl F, Çakılcıoğlu U. Research on for in Bigadiç (Balıkesir-Turkey). TDFD. 2022;11(4):142-7.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 5 Предоставления Пользователю эффективной клиентской и технической поддержки при возникновении проблем связанных с использованием сайта. 4. 1. 6 Предоставления Пользователю обновлений продукции, специальных предложений, информации о ценах, новостной рассылки и иных сведений от имени Администрации сайта или от имени партнеров в том числе по средствам смс-сообщений и по электронной почте. 4. 1. 7 Осуществления рекламной деятельности. 4. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: : 2573-4555 Journal of & -in-for Manuscript 10. 4172/2573-4555. 1000271 Ethnobotany of Used to in Ethiopia: A Yibeltal Aschale1, Muluken Wubetu2* and Haimanot Reta31Department of Medical Parasitology, College of Medicine and 2Department of Pharmacy, College of 3Department of Biology and Botanical Science, College of Natural and Computational Science, Debre Markos, Ethiopia *Corresponding Author: Muluken Wubetu, Department of Pharmacy, College of : mulukenwubetu1986@gmail. com Received: 21-Feb-2018 Accepted Date: 06-Mar-2018 Published Date: 12-Mar-2018 DOI: 10. 4172/2573-4555. 1000271 Abstract Background: Leishmaniasis is an infectious tropical vector born disease imposing high burden in developing countries including Ethiopia. Its treatment is still using pentavalent antimonial which have been used for several years and prone to drug resistance. Other alternative drugs like amphotericin B also have horrible side effects. Therefore, new drugs are urgently needed and drug screening efforts should be encouraged. No review has been done that broadly indicates medicinal plants used to treat leishmaniasis. The aim of this review was to provide an overview of the Ethnobotany of medicinal plants used to treat leishmaniasis in Ethiopia. Materials and methods: Databases (Pub Med, 53. 6% were herbs and the common plant part used was leaf (44. 8%) followed by latex (20. 7%). Majority of the plant remedies were given topically (75. 7%). Cutaneous leishmaniasis comprises high percentage of leishmania infection treated by traditional medicinal plants. Conclusion: Varity of medicinal plants have been used by Ethiopian people of different cultures to treat leishmaniasis. Most of the plants were herbs and the commonly used plant part was leaf. Majority of prepared remedies were applied externally to the affected part. There is an urgent need to conduct clinical trials on such plants to support traditional claims and to analyze molecular and cellular mechanisms involved. : Ethnobotany; Leishmaniasis; Medicinal plants; Review; Leishmaniasis is a tropical disease caused by protozoan parasites of the genus leishmania [1].

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 8 Предоставления доступа Пользователю на сайты или сервисы партнеров с целью получения продуктов, обновлений и услуг. 5. СПОСОБЫ И СРОКИ ОБРАБОТКИ ПЕРСОНАЛЬНОЙ ИНФОРМАЦИИ 5.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. Competing Interests: No conflicts of Report a concern Respond or 29 Aug 2023 of 29 Aug 2023 In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the. . . Continue reading In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver. In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: It is one of neglected disease and even not include in the list of tropical disease priorities in Ethiopia [2]. Leishmaniasis has a focal distribution and it is common to remote areas like other neglected tropical disease [3]. Visceral leishmaniasis specially is recognized as serious public health problem as it causes death if left untreated having high case fatality rate [4]. Lack of simple and easily applied tools for its management and complex ecoepidemiology contribute for the difficulty in prevention and control of the disease [3,5]. Plants remain to be the source for majority of people in developing countries to treat various health problems [6]. They are a rich source of many natural products most of which have been extensively used for human welfare, and treatment of various diseases [7,8]. a variety of medicinal plants are used as natural medicines without scientific base. Plant extracts or plant derived compounds provide important source of new medicinal agents [9,10]. A high diversity of secondary metabolites with interesting biological activities can be produced from plant extracts [11]. About eighty (80%) percent of the Ethiopia people and ninety percent (90% ) of livestock depend on traditional medicine for their health care and more than 95 percent of traditional medicine preparations are made from plant origin. Similarly, there has been a continuous growth of demand for traditional medicines globally and in many developing countries health care system [12]. Urgent need for alternative drug formulation leads to screening of natural products for potential use in leishmaniasis treatment. Different studies have been conducted on Ethnobotany of medicinal plants used to treat various human diseases in different parts of Ethiopia. However, there has not been any review conducted on Ethnobotany of plants used to treat Leishmaniasis. Therefore, there is an urgent need to assess the overall traditional preparation techniques and types of plants used in the management of leishmaniasis. This review is complementary of various medicinal plants that have been directed towards plants having leishmanicidal activity. It gives a comprehensive information on the scientific name of plants, method of preparation, route of administration, plant part used and the habit of the plant used. This review will also give new force for obtaining synthetic compounds. Materials and methods Search strategy Databases (Pub Med, 53. 6%) followed by shrubs (28. 6%) (Figure 2). The commonly used plant parts were leaves (44. 8 %) followed by latex (20. 7%). Root account 17.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 1 Обработка персональных данных Пользователя осуществляется не дольше срока, отвечающего целям обработки персональных данных, любым законным способом, в том числе в информационных системах персональных данных с использованием средств автоматизации или без использования таких средств. 5.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion. We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. In “The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study”, Koritala, Dakup, and colleagues explore the outcome of short- and long-term exposure to rotating shift work compared to normal conditions and jet lag in circadian rhythms of the skin and liver in mice. This aims to fill a knowledge gap where only short-term shift work experiments have been conducted on humans in laboratory settings, whereas human shift workers tend to engage in rotating shift work for many years. find that, in general, short-term shift work has a subtle effect on rhythmicity of molecular clock gene expression, particularly in the liver.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: According to this review, herbs constitute the highest percentage of the plants identified to have medicinal value in the treatment of leishmaniasis followed by shrubs. Similarly, other studies conducted elsewhere in Ethiopia indicated the dominance of herbs [29-34]. Herbs are seasonal which indicates that they are not accessible throughout the year which needs storage but can be easily cultivated in a limited area. However, Shrubs are known to be non-seasonal in nature which implies that they are accessible throughout a year and no need to store. In this review, leaf was the most commonly used plant part in the preparation of remedies as compared to other parts. Studies conducted in Nigeria [28] and Israel [35] also showed the dominance of leaves in the preparation of remedies. However, the use of plants leaf for medicinal purposes has its own limitations unless the plant is evergreen. Because leaves are seasonal this implies that they are not available throughout a year which needs storage if non-fresh leaves are required. There is no threat to the mother plant when leaves are harvested for medicinal purpose instead the highest threat to the mother plant comes with root, bark and stem harvest. Medicinal plants were formulated in various forms using different solvents and additives. Traditional medicinal Practitioners prepare remedies in such a simple manner without need of advanced techniques and further processing. This may be due to lack of formal education and processing instruments. Practitioners used butter, porridge, sugar, and honey as additives to increase the medicinal value/potency of the remedies. This is agreed with a study conducted in Israel [35] and Hawassa [36]. This review also revealed that high proportions of remedies were given topically. The reason for this is, traditional medicinal practitioners prefer simple routes like topical and oral that do not require special skill due to lack of ability to administer remedies in other complex routes like intravenous and intramuscular. As leishmania parasite is found in the affected area and medicines are applied to the affected area, topical routes allow rapid interaction between the prepared medicines and the parasite increasing its potency. Another study conducted in Sheko ethnic group of revealed that the most medicinal plant preparations were administered cutaneously [37]. Even though unspecified Leishmania infections were reported, in this review cutaneous and visceral leishmaniasis were the common Leishmania infections that can be treated traditionally when encountered in human using medicinal plants.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Пользователь соглашается с тем, что Администрация сайта вправе предоставить персональные данные третьим лицам, в частности, курьерским службам, организациями почтовой связи, операторам электросвязи, партнерам исключительно в целях оказания услуг. 5. 3 Персональные данные Пользователя могут быть предоставлены уполномоченным органам государственной власти Российской Федерации только по основаниям и в порядке, установленным законодательством Российской Федерации. 5.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: In longer-term shift work and jet lag, the Cry genes were the most sensitive to disruption; however, long-term shift work and jet lag both dramatically affected the oscillatory characteristics of many circadian genes, often in a disparate fashion. conclude that different rotating work and sleep schedules can have outsize impacts on molecular clock oscillation that may vary between tissues. Overall, this is a well-designed and executed study with clear outcomes and interpretable results. I have several minor suggestions and comments that I believe will enhance the quality of the final manuscript. Authors' response: We appreciate the reviewer’s constructive and positive feedback on our manuscript. 1. This study was only carried out in male mice, which goes against the NIH policy “Consideration of Sex as a in NIH-funded Research” (NOT-OD-15-102). should discuss this in their Limitations section, and how the outcomes may be different in females. Authors' response: We thank the reviewer for highlighting this. We concur and have addressed the exclusive use of male mice in the limitations section, including potential differences in female outcomes. 2. 4, it is difficult to assess which oscillation characteristics are significantly different from control just by looking at the figure. I am aware that full statistics are available in Table 1, but it would be best if the Authors also figured out a way to represent, perhaps with a different shape (a star instead of a circle? ) which datapoints were significantly different in Figure 4. Authors' response: Great suggestion. We revised Figure 4 to visually highlight the significantly different datapoints. 3. In the Discussion, the Authors mainly focus on the observed differences between short-term and long-term rotating shift work, which is indeed important. Equally important is the fact that many papers and groups use the jet lag protocol as a proxy for shift work, and the Authors demonstrate here that the outcomes of jet lag can be quite different from either short-term or long-term rotating shift work. This is a very important finding that should be addressed in the Discussion. Authors' response: Thank you for highlighting this. We've updated our Discussion section to emphasize the differences between jet lag outcomes and the effects of both short-term and long-term rotating shift work. Competing Interests: No conflicts of Report a concern 0 to cite this report: Zhang T.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: The mechanism of action of Plant extracts and isolated secondary metabolites like flavonoids is often by interfering with central targets of Leishmania parasites (intercalation with DNA, alkylation of DNA), membrane integrity, microtubules and neuronal signal transduction [11]. the present review, a total of twenty eight medicinal plants have been identified and recorded for their use for the treatment of leishmaniasis in Ethiopia. Most of the plants were herbs and the commonly used plant part was leaf. Even though most of these medicinal plants are widely utilized in different provinces of Ethiopia, information on their safety and efficacy are not scientifically proofed by using animal models. Therefore, it is advisable for researchers to conduct the safety and efficacy studies of the traditionally claimed medicinal plants in more detail in animal models and if possible in clinical trials. approval and consent to participate Not applicable Consent for applicable Availability of Data and additional data are required; all information is clearly stated in the main manuscript. The authors have declared that there is no competing interest. funding was obtained for this study. Authors’ Contribution MW, YA conceive the review, YA involved in data extraction, data analysis, interpretation and drafting of the manuscript. HR involved in data analysis and quality assessment. MW Critically reviewed the manuscript. All authors reviewed and approved the manuscript. applicable 250. (2004) Combating tropical infectious diseases: report of the Priorities in Project. Dis 6: 871-878 (2008) Complexities of assessing the disease burden attributable to leishmaniasis. 10: e313 (2005) Risk factors for kala-azar in Bangladesh. Dis 5: 655 (2006) Leishmaniasis and poverty. 12: 552-557. Birhanu A, (2017) of Used for the Treatment of Human and in District of Bale Zone, Southeast Ethiopia. 4: 5043-5055 (2015) An ethnomedicinal investigation of plants used by traditional healers of Gondar town, North-Western Ethiopia. J Res 2: 36-43 (2013) Traditional medicinal plants: a source of phytotherapeutic modality in resource-constrained health care settings. 1: 67-74 (2001) Leishmaniasis phytotherapy. Nature's leadership against an ancient disease.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 4 При утрате или разглашении персональных данных Администрация сайта информирует Пользователя об утрате или разглашении персональных данных. 5. 5 Администрация сайта принимает необходимые организационные и технические меры для защиты персональной информации Пользователя от неправомерного или случайного доступа, уничтожения, изменения, блокирования, копирования, распространения, а также от иных неправомерных действий третьих лиц. 5.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where. . . Continue reading this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Why use two housekeeping genes in the same tissue for clock gene relative quantification? The author should discuss why Cry genes are preferentially altered under three light conditions. Is the work clearly and accurately presented and does it cite the current literature? the study design appropriate and is the work technically sound? sufficient details of methods and analysis provided to allow replication by others? applicable, is the statistical analysis and its interpretation appropriate? all the source data underlying the results available to ensure full reproducibility? the conclusions drawn adequately supported by the results? Yes 1. Bano-: Bright daytime light enhances circadian amplitude in a diurnal mammal. . 2021; 118 (22). Pub| Text 2. Alves-: Effects of type of light on mouse circadian behaviour and stress levels. Lab Anim. 2016; 50 (1): 21-9 Pub| Text 3. : Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice. Metab.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Fitoterapia 6: 599-618 Kayser O, Kiderlen AF (2001) In vitro leishmanicidal activity of naturally occurring chalcones. 2: 148-52 (2012) Medicinal plants: a source of anti-parasitic secondary metabolites. Molecules 11: 12771-91 (2017) A survey on medicinal plants used by traditional healers in Harari regional State, East Ethiopia. J Res1: 85-90 Flora of Ethiopia and Eritrea. Edited by Hedberg I, Edwards S. Addis Ababa, Ethiopia and Uppsala, Sweden: Uppsala University; 2009: Vol. 8. (1994) Usersâ€™ guides to the medical literature II: how to use an 22. (2013) An ethnobotanical study of medicinal plants used in District, of Ethiopia. J 1: 65 Suleman S, (2012) A survey on utilization of ethnomedicinal plants in Nekemte town, (Oromia), Ethiopia. J 1: 34-57 (2014) An ethnobotanical study of medicinal plants in Amaro woreda, Ethiopia. (2007) Knowledge and use of medicinal plants by people around monastery in Ethiopia. J Ethnopharmacol 2: 271-83 (2009) Ethnobotanical study of knowledge and medicinal plants use by the people in in Ethiopia. J Ethnopharmacol 1: 69-78 (2009) Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study. J Ethnopharmacol 3: 513-21 (2005) Survey of medicinal plants used to treat human diseases in Seka Chekorsa, Jimma Zone, Ethiopia. 2 (2007) Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia. J Ethnopharmacol 3: 516-25 (2013) Medicinal plants traditionally used in the northwest Spain. J Ethnopharmacol 4: 01-22. Mi-(2013) Ethno pharmacological survey of medicinal plants in Jeju Island, Korea. J 9: 48. (2007) The perception and practice of traditional medicine in the treatment of cancers and inflammations by the Hausa and Fulani tribes of Northern Nigeria.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 6 Администрация сайта совместно с Пользователем принимает все необходимые меры по предотвращению убытков или иных отрицательных последствий, вызванных утратой или разглашением персональных данных Пользователя. 6. ОБЯЗАТЕЛЬСТВА СТОРОН 6. 1 Пользователь обязан: 6. 1. 1 Предоставить информацию о персональных данных, необходимую для пользования сайтом. 6. 1.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2022; 322 (1): E1-E9 Pub| Interests: No competing interests were disclosed. Reviewer Expertise: circadian clock and metabolism I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. . For: The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 3; peer review: 2 approved]. F1000Research 2023, 12:762 ( The direct URL for this report is: Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol. 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: HomeBIJEthnobotany of medicinal plants used to treat malaria by traditional healers from ten indigenous colombian communities located in waupes medio Submit manuscript. . . eISSN: 2575-906X 167. DOI: 10. 15406/bij. 2017. 01. 00022 indigenous communities from possess knowledge in the use of plants to treat their illnesses. This knowledge has been transmitted orally from generation to generation. The present 3. 2billion people remain at risk of malaria. Annually, it produces between 149-303million clinical cases and kills more than 400,000 people. Among those killed, 90% are children under 5years old. 1 America, the transmission of paludism is found in nine countries sharing the amazon forest region and in 8 countries representing the Caribbean and Central America. 2 in 2016, 83 356 cases of malaria were reported to the Institute (INS) through the (Sivigila), and the distribution by species corresponded to 47 497 cases (57%) by P. falciparum, followed by P. vivax with 33 055 cases (39. 7%) and 2 804 cases (3. 3%) of mixed infections (P. falciparum and P. vivax). In addition, 19 deaths were confirmed because of this disease in Colombian territory. 3 These data show the importance of this disease in the panorama of morbidity and mortality at local and global level. Natural or vector borne infection in humans is by six species from the genus Plasmodium: P. falciparum, P. vivax, P. ovale, P. malariae, P. knowlesi,1 and recently P. cynomolgi. 4 This parasite is transmitted to humans by the bite of the Anopheles mosquito. Once inside the organism, the parasite causes clinical symptoms that can range from mild to grave, or even lead to fatal. 5,6 Traditional medicine uses plants to treat different illnesses, and their use is so efficient that the Organization (WHO) estimates that 80% of the world population uses plants as alternative therapy. 7 Since 1670, medical plants like Quina have been used to treat paludic feavers. It was not until 1820 that two French chemists, isolated a metabolite called quinina from this plant.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Обновить, дополнить предоставленную информацию о персональных данных в случае изменения данной информации. 6. 1. 3 Пользователь имеет право отозвать согласие на обработку персональных данных, путем направления уведомления Оператору по адресу электронной почты: info@editorum. ru. 6. 2 Администрация сайта обязана: 6. 2. 1 Использовать полученную информацию исключительно для целей, указанных в п. 4 настоящей Политики конфиденциальности. 6. 2.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). Thus, the utilization of more than one housekeeping gene minimizes this variability. 5. The author should discuss why Cry genes are preferentially altered under three light conditions. Authors' response: In the discussion section of the revised manuscript, we covered the response of Cry genes to simulated shift conditions. In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3. More information should be provided on Circadian rhythm analysis, especially the setting of parameters. Authors' response: In response to the reviewer’s suggestion, we have clarified our use of the standard parameters of the Circapackage (as per Parsons et al. , Bioinformatics, 2020, PMID: 31588519). This approach includes a fixed period of 24 hours. 4. Why use two housekeeping genes in the same tissue for clock gene relative quantification? Authors' response: Vandesompele et al. (Genome Biol.

Output: corroborate


Input: Claim: Plants studied in ethnobotany are never used for ceremonial or spiritual purposes. [SEP] Text: Quinina served as a template for the synthesis of the aminochinolines such as cloroquine, which was used as a first-line medicine until 1971 when the first cases of P. falciparum resistance appeared. 8 This stimulated the search for new antimalarial agents. In 1972 Chinese scientists isolated artemisinin from the Artemisa anua plant. This permitted the synthesis of the artemisinin derivatives artesunate, arteheter, artemether, constituting a new pilar of antimalarial therapy. 9,10 is a region both endemic to malaria and to some of the most diverse ecosystems in the world. One third of the worlds species are found in tropical rain forests. 11 Concurrenty, there exists a wide cultural diversity linked to traditional knowledge from different ethnic groups. This diversity has been affected and threatened by colonization which began in the 15th century and advanced in the 20th century. 12 In the case of Vaupes medio, it was due to the bonanaza of rubber, coca farming, and the sale of animal skins. These processes led to deforestation and an alteration in social structure, bringing about a loss of plant diversity and of the knowledge associated with it. 13 Among the indigenous and mestizo communities located in the of the southeastern part of Colombia, the population is 85% indigenous representing 27 ethnic groups. Among those groups, the most numerous are: Cubeo, Tucano, Desano and Guanano. 14 These communities are effected by malaria, above all, those which are located in the Vaupés Alto, Vaupés Medio, Papunahua, Apaporis river, and at the Querarí river head. In this zone, malaria has been treated by diverse traditional healers from the region using medicinal plants (for preventing it or curing it). Nevertheless, these practices are disappearing due to the social phenomena explained previously. The purpose of this study is to contribute to and preserve the ancestral knowledge related to medicinal use of plants among the communities located in the Vaupés Medio. More specifically, information was collected about medicinal plants used to cure malaria from 33 indigenous traditional healers from this zone. In the presence of the healers, plants were identified and collected. They were later studied taxonomically and the greater frequency of use was determined by the Friedman’s index. Materials and methods Study area An area of 10,901.

Output: contrast


Input: Claim: Sea turtles navigate using the Earth’s magnetic field. [SEP] Text: 2 Обеспечить хранение конфиденциальной информации в тайне, не разглашать без предварительного письменного разрешения Пользователя, а также не осуществлять продажу, обмен, опубликование, либо разглашение иными возможными способами переданных персональных данных Пользователя, за исключением п. п. 5. 2. и 5. 3. настоящей Политики Конфиденциальности. 6. 2.

Output: pass


Input: Claim: Shift work can adversely affect health due to misalignment of circadian rhythms. [SEP] Text: 2002, PMID: 12184808) showed that normalizing with the geometric mean of carefully chosen control genes improves qPCR accuracy. Using a single universal control gene is less effective due to variations across different cells or tissues. Moreover, fluctuations within standard housekeeping genes depending on the time of day have been recognized in studies (Kosir et al. , BMC Mol Biol. 2010; PMID: 20712867). Thus, the utilization of more than one housekeeping gene minimizes this variability. 5. The author should discuss why Cry genes are preferentially altered under three light conditions. Authors' response: In the discussion section of the revised manuscript, we covered the response of Cry genes to simulated shift conditions. Competing Interests: No conflicts of Report a concern Respond or 29 Aug 2023 of 29 Aug 2023 In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the. . . Continue reading In this manuscript, Koritala et al. report that shift-work light affects the circadian rhythms of canonical clock genes in the liver and skin of mice. Although the authors have utilized multiple approaches to test their hypothesis, there remain areas where the methods section should also provide detailed information. Please refer to the following comments for more details. 1. Describe in detail the process for collecting skin, which part of the skin tissue was collected? Authors' response: As per the suggestion of the reviewer, we have elaborated on the procedure of skin tissue collection within the '' section in our methods. 2. Is the selection of light intensity reasonable in the experiment? Multiple studies have shown that bright light can affect the circadian rhythm of activity, metabolism and clock gene expression (Bano-Otalora et al. , 20211; Alves-Simoes et al. , 20162; Fan et al. , 20223). Meanwhile, the light intensity also affects the impact of chronic jet-lag. Authors' response: Our study maintained similar light intensities across control and shift simulation groups to focus on shift impacts, thereby reducing potential variation from light intensity differences. However, recognizing the significance of light intensity on chronic jet-lag, we will consider incorporating this factor into future experimental designs, perhaps by comparing the effects of different light intensities on chronic jet-lag. 3.

Output: corroborate