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.gitattributes

@@ -33,3 +33,9 @@ saved_model/**/* filter=lfs diff=lfs merge=lfs -text
 *.zip filter=lfs diff=lfs merge=lfs -text
 *.zst filter=lfs diff=lfs merge=lfs -text
 *tfevents* filter=lfs diff=lfs merge=lfs -text
+clinical_evidence_data/tahoe_drugs_clinical_trials.csv filter=lfs diff=lfs merge=lfs -text
+data/tahoe_drugs_clinical_trials.csv filter=lfs diff=lfs merge=lfs -text
+data_for_classifier/ldvae_embeddings.tsv filter=lfs diff=lfs merge=lfs -text
+data_for_classifier/ldvae_raw_embeddings.tsv filter=lfs diff=lfs merge=lfs -text
+data_for_classifier/tahoe_pseudobulk_z-space_by_sample.csv filter=lfs diff=lfs merge=lfs -text
+representations/ldvae/ldvae_cellline_drug_aggr.h5ad filter=lfs diff=lfs merge=lfs -text

.gitignore

@@ -0,0 +1,174 @@
+# Byte-compiled / optimized / DLL files
+__pycache__/
+*.py[cod]
+*$py.class
+
+# C extensions
+*.so
+
+# Distribution / packaging
+.Python
+build/
+develop-eggs/
+dist/
+downloads/
+eggs/
+.eggs/
+lib/
+lib64/
+parts/
+sdist/
+var/
+wheels/
+share/python-wheels/
+*.egg-info/
+.installed.cfg
+*.egg
+MANIFEST
+
+# PyInstaller
+#  Usually these files are written by a python script from a template
+#  before PyInstaller builds the exe, so as to inject date/other infos into it.
+*.manifest
+*.spec
+
+# Installer logs
+pip-log.txt
+pip-delete-this-directory.txt
+
+# Unit test / coverage reports
+htmlcov/
+.tox/
+.nox/
+.coverage
+.coverage.*
+.cache
+nosetests.xml
+coverage.xml
+*.cover
+*.py,cover
+.hypothesis/
+.pytest_cache/
+cover/
+
+# Translations
+*.mo
+*.pot
+
+# Django stuff:
+*.log
+local_settings.py
+db.sqlite3
+db.sqlite3-journal
+
+# Flask stuff:
+instance/
+.webassets-cache
+
+# Scrapy stuff:
+.scrapy
+
+# Sphinx documentation
+docs/_build/
+
+# PyBuilder
+.pybuilder/
+target/
+
+# Jupyter Notebook
+.ipynb_checkpoints
+
+# IPython
+profile_default/
+ipython_config.py
+
+# pyenv
+#   For a library or package, you might want to ignore these files since the code is
+#   intended to run in multiple environments; otherwise, check them in:
+# .python-version
+
+# pipenv
+#   According to pypa/pipenv#598, it is recommended to include Pipfile.lock in version control.
+#   However, in case of collaboration, if having platform-specific dependencies or dependencies
+#   having no cross-platform support, pipenv may install dependencies that don't work, or not
+#   install all needed dependencies.
+#Pipfile.lock
+
+# UV
+#   Similar to Pipfile.lock, it is generally recommended to include uv.lock in version control.
+#   This is especially recommended for binary packages to ensure reproducibility, and is more
+#   commonly ignored for libraries.
+#uv.lock
+
+# poetry
+#   Similar to Pipfile.lock, it is generally recommended to include poetry.lock in version control.
+#   This is especially recommended for binary packages to ensure reproducibility, and is more
+#   commonly ignored for libraries.
+#   https://python-poetry.org/docs/basic-usage/#commit-your-poetrylock-file-to-version-control
+#poetry.lock
+
+# pdm
+#   Similar to Pipfile.lock, it is generally recommended to include pdm.lock in version control.
+#pdm.lock
+#   pdm stores project-wide configurations in .pdm.toml, but it is recommended to not include it
+#   in version control.
+#   https://pdm.fming.dev/latest/usage/project/#working-with-version-control
+.pdm.toml
+.pdm-python
+.pdm-build/
+
+# PEP 582; used by e.g. github.com/David-OConnor/pyflow and github.com/pdm-project/pdm
+__pypackages__/
+
+# Celery stuff
+celerybeat-schedule
+celerybeat.pid
+
+# SageMath parsed files
+*.sage.py
+
+# Environments
+.env
+.venv
+env/
+venv/
+ENV/
+env.bak/
+venv.bak/
+
+# Spyder project settings
+.spyderproject
+.spyproject
+
+# Rope project settings
+.ropeproject
+
+# mkdocs documentation
+/site
+
+# mypy
+.mypy_cache/
+.dmypy.json
+dmypy.json
+
+# Pyre type checker
+.pyre/
+
+# pytype static type analyzer
+.pytype/
+
+# Cython debug symbols
+cython_debug/
+
+# PyCharm
+#  JetBrains specific template is maintained in a separate JetBrains.gitignore that can
+#  be found at https://github.com/github/gitignore/blob/main/Global/JetBrains.gitignore
+#  and can be added to the global gitignore or merged into this file.  For a more nuclear
+#  option (not recommended) you can uncomment the following to ignore the entire idea folder.
+#.idea/
+
+# Ruff stuff:
+.ruff_cache/
+
+# PyPI configuration file
+.pypirc

LICENSE

@@ -0,0 +1,674 @@
+                    GNU GENERAL PUBLIC LICENSE
+                       Version 3, 29 June 2007
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+free software which everyone can redistribute and change under these terms.
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+to attach them to the start of each source file to most effectively
+state the exclusion of warranty; and each file should have at least
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+    it under the terms of the GNU General Public License as published by
+    the Free Software Foundation, either version 3 of the License, or
+    (at your option) any later version.
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+    but WITHOUT ANY WARRANTY; without even the implied warranty of
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+
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+if any, to sign a "copyright disclaimer" for the program, if necessary.
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+<https://www.gnu.org/licenses/>.
+
+  The GNU General Public License does not permit incorporating your program
+into proprietary programs.  If your program is a subroutine library, you
+may consider it more useful to permit linking proprietary applications with
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+Public License instead of this License.  But first, please read
+<https://www.gnu.org/licenses/why-not-lgpl.html>.

README.md

@@ -0,0 +1,14 @@
+# clinOracle team - tahoe-hack-2025
+
+Predicting clinical outcomes from _in vitro_ transcriptional responses.
+
+## Code
+- `representations/` - scripts to train and transcriptome effect representations on Tahoe-100M 
+- `clinical_data_curation/` - scripts to curate clinical trial data
+- `approval_prediction_benchmark.ipynb` - benchmark on clinical approval prediction
+- `classifier.py` - Benchmarking classifier implementation
+
+## Data
+- `clinical_evidence_data/` - Curated clinical evidence data on Tahoe drugs
+- `data_for_classifier/` - input data for benchmarks
+- `data/` - misc processed data

_misc/depmap.ipynb

@@ -0,0 +1,107 @@
+{
+ "cells": [
+  {
+   "cell_type": "code",
+   "execution_count": 1,
+   "metadata": {},
+   "outputs": [
+    {
+     "name": "stderr",
+     "output_type": "stream",
+     "text": [
+      "/home/ubuntu/miniconda3/envs/rapids_singlecell/lib/python3.12/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n",
+      "  from .autonotebook import tqdm as notebook_tqdm\n"
+     ]
+    }
+   ],
+   "source": [
+    "from datasets import load_dataset\n",
+    "import pandas as pd"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 3,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "drug_metadata = pd.DataFrame(load_dataset(\"tahoebio/Tahoe-100M\",\"drug_metadata\", split=\"train\"))\n",
+    "drug_metadata = drug_metadata.loc[drug_metadata[\"targets\"].notna()]\n",
+    "target_to_drug = dict(zip(drug_metadata[\"targets\"], drug_metadata[\"drug\"]))\n",
+    "cell_metadata = pd.DataFrame(load_dataset(\"tahoebio/Tahoe-100M\",\"cell_line_metadata\", split=\"train\"))\n",
+    "depmap = pd.read_csv(\"../CRISPRGeneDependency.csv\", index_col=0)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 4,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "depmap_to_tahoe = dict(zip(cell_metadata[\"Cell_ID_DepMap\"], cell_metadata[\"Cell_ID_Cellosaur\"]))\n",
+    "depmap.index = depmap.index.map(depmap_to_tahoe)\n",
+    "depmap = depmap.loc[depmap.index.notna()]\n",
+    "depmap.columns = depmap.columns.map(lambda x: x.split(\" \")[0])"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 5,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "depmap = depmap.reset_index().melt(id_vars='index')\n",
+    "depmap[\"drug\"] = depmap[\"variable\"].map(target_to_drug)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 6,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "depmap = depmap.dropna(subset=[\"drug\"])\n",
+    "depmap[\"drug_cellline\"] = depmap[\"drug\"] + \"_\" + depmap[\"index\"]"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 9,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "depmap.index = depmap[\"drug_cellline\"]\n",
+    "depmap[\"depmap_dependency_score\"] = depmap[\"value\"]\n",
+    "depmap[[\"depmap_dependency_score\"]].to_csv(\"data_for_classifier/depmap_dependency_scores.tsv\", index=True, sep='\\t')"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "metadata": {},
+   "outputs": [],
+   "source": []
+  }
+ ],
+ "metadata": {
+  "kernelspec": {
+   "display_name": "Python 3",
+   "language": "python",
+   "name": "python3"
+  },
+  "language_info": {
+   "codemirror_mode": {
+    "name": "ipython",
+    "version": 3
+   },
+   "file_extension": ".py",
+   "mimetype": "text/x-python",
+   "name": "python",
+   "nbconvert_exporter": "python",
+   "pygments_lexer": "ipython3",
+   "version": "3.12.10"
+  }
+ },
+ "nbformat": 4,
+ "nbformat_minor": 2
+}

_misc/genedisease_to_drugtrait.ipynb

@@ -0,0 +1,199 @@
+{
+ "cells": [
+  {
+   "cell_type": "code",
+   "execution_count": 48,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "from datasets import load_dataset\n",
+    "import pandas as pd"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 49,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "# import json\n",
+    "# import os\n",
+    "\n",
+    "# # Read in the organ to conditions mapping JSON file\n",
+    "# with open(\"clin-oracle-tahoe-hack-2025/data/organ_to_conditions_mapping.json\", \"r\") as f:\n",
+    "#     organ_to_conditions = json.load(f)\n",
+    "    \n",
+    "# # Display basic information about the mapping\n",
+    "# print(f\"Loaded organ to conditions mapping with {len(organ_to_conditions)} organs\")\n",
+    "# print(f\"Sample organ: {list(organ_to_conditions.keys())[0]}\")\n",
+    "# print(f\"Sample conditions: {organ_to_conditions[list(organ_to_conditions.keys())[0]][:3]}...\")\n"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 55,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "drug_metadata = pd.DataFrame(load_dataset(\"tahoebio/Tahoe-100M\",\"drug_metadata\", split=\"train\"))\n",
+    "drug_metadata = drug_metadata.loc[drug_metadata[\"targets\"].notna()]\n",
+    "target_to_drug = dict(zip(drug_metadata[\"targets\"], drug_metadata[\"drug\"]))"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 57,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "df = pd.read_csv(\"/home/ubuntu/tahoe/clin-oracle-tahoe-hack-2025/indication_to_organ_mapping_confident.tsv\", sep='\\t')"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 58,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "indic = pd.read_csv(\"genetic_support/data/indic.tsv\", sep='\\t')\n",
+    "assoc = pd.read_csv(\"genetic_support/data/assoc.tsv.gz\", sep='\\t')"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 59,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "assoc = assoc.merge(df, left_on=\"mesh_term\", right_on=\"indication_mesh_term\")"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 61,
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "189"
+      ]
+     },
+     "execution_count": 61,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "len(target_to_drug)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 62,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "assoc[\"drug\"] = assoc[\"gene\"].map(target_to_drug)\n",
+    "assoc[\"drug_organ\"] = assoc[\"drug\"] + \"_\" + assoc[\"organ\"]"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 63,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "assoc = assoc.loc[assoc[\"drug_organ\"].notna()]"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "assoc[[\"drug_organ\",]]"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 66,
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "arow                                                                 3885\n",
+       "gene                                                                 ABL1\n",
+       "mesh_id                                                           D014012\n",
+       "source                                                                OTG\n",
+       "original_trait          Tinnitus / tiniitis | non-cancer illness code,...\n",
+       "original_link           https://genetics.opentargets.org/study/NEALE2_...\n",
+       "extra_info                                                            NaN\n",
+       "l2g_rank                                                              4.0\n",
+       "l2g_share                                                            0.12\n",
+       "pval                                                                  0.0\n",
+       "year                                                               2018.0\n",
+       "beta                                                                  NaN\n",
+       "odds_ratio                                                       4.072184\n",
+       "pic_qtl_pval                                                          NaN\n",
+       "pic_h4                                                                NaN\n",
+       "af_gnomad_nfe                                                     0.02489\n",
+       "mesh_term                                                        Tinnitus\n",
+       "indication_mesh_term                                             Tinnitus\n",
+       "organ                                                           CNS/Brain\n",
+       "drug                                                Flumatinib (mesylate)\n",
+       "drug_organ                                Flumatinib (mesylate)_CNS/Brain\n",
+       "Name: 234, dtype: object"
+      ]
+     },
+     "execution_count": 66,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "assoc.iloc[0]"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 67,
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "assoc[\"is_associated_with_indication\"] = 1\n",
+    "assoc[[\"drug_organ\",\"is_associated_with_indication\"]].to_csv(\"/home/ubuntu/tahoe/clin-oracle-tahoe-hack-2025/data_for_classifier/assoc_drug_organ_label.tsv\", sep='\\t', index=False)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "metadata": {},
+   "outputs": [],
+   "source": []
+  }
+ ],
+ "metadata": {
+  "kernelspec": {
+   "display_name": "Python 3",
+   "language": "python",
+   "name": "python3"
+  },
+  "language_info": {
+   "codemirror_mode": {
+    "name": "ipython",
+    "version": 3
+   },
+   "file_extension": ".py",
+   "mimetype": "text/x-python",
+   "name": "python",
+   "nbconvert_exporter": "python",
+   "pygments_lexer": "ipython3",
+   "version": "3.12.10"
+  }
+ },
+ "nbformat": 4,
+ "nbformat_minor": 2
+}

_misc/harmonize_genetic_data.py

@@ -0,0 +1,344 @@
+import pandas as pd
+import re
+
+def load_indications(file_path):
+    """
+    Load indications from a TSV file.
+    """
+    try:
+        # Read the TSV file
+        df = pd.read_csv(file_path, sep='\t', na_values=['', 'NA', 'N/A'])
+        return df
+    except Exception as e:
+        print(f"Error loading file: {e}")
+        return None
+
+def map_indication_to_organ(indication, areas=None):
+    """
+    Map a medical indication to an organ.
+    Returns the organ name if a confident mapping exists, otherwise None.
+    """
+    # List of target organs
+    target_organs = [
+        'Bowel', 'Lung', 'Esophagus/Stomach', 'Pancreas', 'Skin', 
+        'Uterus', 'Breast', 'Ovary/Fallopian Tube', 'Cervix', 
+        'CNS/Brain', 'Liver', 'Kidney', 'Peripheral Nervous System', 
+        'Vulva/Vagina', 'Bladder/Urinary Tract'
+    ]
+    
+    # Dictionary mapping indication keywords to organs
+    keyword_to_organ = {
+        # Bowel related
+        'bowel': 'Bowel',
+        'intestinal': 'Bowel',
+        'colon': 'Bowel',
+        'colorectal': 'Bowel',
+        'rectal': 'Bowel',
+        'anus': 'Bowel',
+        'colitis': 'Bowel',
+        'crohn': 'Bowel',
+        'inflammatory bowel': 'Bowel',
+        'diverticulitis': 'Bowel',
+        'ileus': 'Bowel',
+        'short bowel': 'Bowel',
+        
+        # Lung related
+        'lung': 'Lung',
+        'pulmonary': 'Lung',
+        'respiratory': 'Lung',
+        'bronch': 'Lung',
+        'pneumonia': 'Lung',
+        'emphysema': 'Lung',
+        'asthma': 'Lung',
+        'chronic obstructive pulmonary': 'Lung',
+        'idiopathic pulmonary fibrosis': 'Lung',
+        
+        # Esophagus/Stomach related
+        'esophag': 'Esophagus/Stomach',
+        'stomach': 'Esophagus/Stomach',
+        'gastric': 'Esophagus/Stomach',
+        'gastroesophageal': 'Esophagus/Stomach',
+        'duodenal': 'Esophagus/Stomach',
+        'peptic ulcer': 'Esophagus/Stomach',
+        'gastritis': 'Esophagus/Stomach',
+        'barrett': 'Esophagus/Stomach',
+        
+        # Pancreas related
+        'pancrea': 'Pancreas',
+        'exocrine pancreatic': 'Pancreas',
+        
+        # Skin related
+        'skin': 'Skin',
+        'dermat': 'Skin',
+        'cutaneous': 'Skin',
+        'melanoma': 'Skin',
+        'psoriasis': 'Skin',
+        'eczema': 'Skin',
+        'acne': 'Skin',
+        'rosacea': 'Skin',
+        'alopecia': 'Skin',
+        'vitiligo': 'Skin',
+        'keratosis': 'Skin',
+        'keloid': 'Skin',
+        'ichthyosis': 'Skin',
+        'pruritus': 'Skin',
+        'urticaria': 'Skin',
+        'pemphigus': 'Skin',
+        'pemphigoid': 'Skin',
+        'scleroderma': 'Skin',
+        
+        # Uterus related
+        'uter': 'Uterus',
+        'endometri': 'Uterus',
+        'myometri': 'Uterus',
+        'leiomyoma': 'Uterus',
+        
+        # Breast related
+        'breast': 'Breast',
+        'mammary': 'Breast',
+        
+        # Ovary/Fallopian tube related
+        'ovar': 'Ovary/Fallopian Tube',
+        'fallopian': 'Ovary/Fallopian Tube',
+        'polycystic ovary': 'Ovary/Fallopian Tube',
+        
+        # Cervix related
+        'cervix': 'Cervix',
+        'cervical': 'Cervix',
+        
+        # CNS/Brain related
+        'brain': 'CNS/Brain',
+        'central nervous': 'CNS/Brain',
+        'cns': 'CNS/Brain',
+        'cerebr': 'CNS/Brain',
+        'alzheimer': 'CNS/Brain',
+        'parkinson': 'CNS/Brain',
+        'glioma': 'CNS/Brain',
+        'glioblastoma': 'CNS/Brain',
+        'medulloblastoma': 'CNS/Brain',
+        'meningioma': 'CNS/Brain',
+        'epilepsy': 'CNS/Brain',
+        'dementia': 'CNS/Brain',
+        'encephalitis': 'CNS/Brain',
+        'encephalopathy': 'CNS/Brain',
+        'huntington': 'CNS/Brain',
+        'multiple sclerosis': 'CNS/Brain',
+        'stroke': 'CNS/Brain',
+        
+        # Liver related
+        'liver': 'Liver',
+        'hepat': 'Liver',
+        'biliary': 'Liver',
+        'cholang': 'Liver',
+        'cirrhosis': 'Liver',
+        'fatty liver': 'Liver',
+        
+        # Kidney related
+        'kidney': 'Kidney',
+        'renal': 'Kidney',
+        'nephro': 'Kidney',
+        'nephri': 'Kidney',
+        'glomerulo': 'Kidney',
+        'polycystic kidney': 'Kidney',
+        
+        # Peripheral Nervous System related
+        'peripheral nervous': 'Peripheral Nervous System',
+        'neuropathy': 'Peripheral Nervous System',
+        'neuralgia': 'Peripheral Nervous System',
+        
+        # Vulva/Vagina related
+        'vulva': 'Vulva/Vagina',
+        'vagina': 'Vulva/Vagina',
+        'vulvar': 'Vulva/Vagina',
+        'vaginal': 'Vulva/Vagina',
+        'vaginitis': 'Vulva/Vagina',
+        
+        # Bladder/Urinary Tract related
+        'bladder': 'Bladder/Urinary Tract',
+        'urinary': 'Bladder/Urinary Tract',
+        'urethral': 'Bladder/Urinary Tract',
+        'urethra': 'Bladder/Urinary Tract',
+        'cystitis': 'Bladder/Urinary Tract',
+    }
+    
+    # Indications that are too general or affect multiple systems
+    too_general = [
+        'Neoplasms', 'Inflammation', 'Pain', 'Infection', 'Fever', 
+        'Autoimmune Diseases', 'Immune System Diseases', 
+        'Nervous System Diseases', 'Metabolic Diseases', 
+        'Arthritis', 'Diabetes Mellitus', 'Hypertension',
+        'Depression', 'Anxiety Disorders', 'HIV Infections',
+        'Sepsis', 'Wound Healing', 'Cachexia', 'Fatigue',
+        'Nausea', 'Vomiting', 'Multiple Myeloma', 'Leukemia', 'Lymphoma'
+    ]
+    
+    # Specific disease to organ mapping
+    specific_disease_mapping = {
+        'Ulcerative Colitis': 'Bowel',
+        'Crohn Disease': 'Bowel',
+        'Asthma': 'Lung',
+        'Psoriasis': 'Skin',
+        'Lupus Erythematosus, Cutaneous': 'Skin',
+        'Lupus Nephritis': 'Kidney',
+        'Alzheimer Disease': 'CNS/Brain',
+        'Parkinson Disease': 'CNS/Brain',
+        'Amyotrophic Lateral Sclerosis': 'CNS/Brain',
+        'Huntington Disease': 'CNS/Brain',
+        'Non-alcoholic Fatty Liver Disease': 'Liver',
+        'Carcinoma, Non-Small-Cell Lung': 'Lung',
+        'Small Cell Lung Carcinoma': 'Lung',
+        'Liver Cirrhosis': 'Liver',
+        'Liver Neoplasms': 'Liver',
+        'Liver Cirrhosis, Biliary': 'Liver',
+        'Breast Neoplasms': 'Breast',
+        'Ovarian Neoplasms': 'Ovary/Fallopian Tube',
+        'Brain Neoplasms': 'CNS/Brain',
+        'Brain Injuries': 'CNS/Brain',
+        'Brain Injuries, Traumatic': 'CNS/Brain',
+        'Brain Ischemia': 'CNS/Brain',
+        'Pancreatic Neoplasms': 'Pancreas',
+        'Urinary Bladder Neoplasms': 'Bladder/Urinary Tract',
+        'Stomach Neoplasms': 'Esophagus/Stomach',
+        'Uterine Cervical Neoplasms': 'Cervix',
+        'Endometrial Neoplasms': 'Uterus',
+        'Kidney Neoplasms': 'Kidney',
+        'Colorectal Neoplasms': 'Bowel',
+        'Inflammatory Bowel Diseases': 'Bowel',
+        'COVID-19': 'Lung',
+        'Severe Acute Respiratory Syndrome': 'Lung',
+        'Pulmonary Disease, Chronic Obstructive': 'Lung',
+        'Idiopathic Pulmonary Fibrosis': 'Lung',
+        'Respiratory Distress Syndrome': 'Lung',
+        'Esophageal Neoplasms': 'Esophagus/Stomach',
+        'Acne Vulgaris': 'Skin',
+        'Psoriatic Arthritis': 'Skin',
+        'Alopecia': 'Skin',
+        'Alopecia Areata': 'Skin',
+        'Vitiligo': 'Skin',
+        'Rosacea': 'Skin',
+        'Hidradenitis Suppurativa': 'Skin',
+        'Pemphigus': 'Skin',
+        'Pemphigoid, Bullous': 'Skin',
+        'Scleroderma, Systemic': 'Skin',
+        'Scleroderma, Diffuse': 'Skin',
+        'Scleroderma, Limited': 'Skin',
+        'Fallopian Tube Neoplasms': 'Ovary/Fallopian Tube',
+        'Polycystic Ovary Syndrome': 'Ovary/Fallopian Tube',
+        'Endometriosis': 'Uterus',
+        'Leiomyoma': 'Uterus',
+        'Carcinoma, Squamous Cell': 'Skin',
+        'Neoplasms, Basal Cell': 'Skin',
+        'Melanoma': 'Skin',
+        'Glioblastoma': 'CNS/Brain',
+        'Medulloblastoma': 'CNS/Brain',
+        'Irritable Bowel Syndrome': 'Bowel',
+        'Diabetic Nephropathies': 'Kidney',
+        'Diabetic Neuropathies': 'Peripheral Nervous System',
+        'Multiple Sclerosis': 'CNS/Brain',
+    }
+    
+    # First, check if the indication is too general
+    if indication in too_general:
+        return None
+        
+    # Check if the indication is in our specific disease mapping
+    if indication in specific_disease_mapping:
+        return specific_disease_mapping[indication]
+    
+    # Check for keyword matches
+    indication_lower = indication.lower()
+    for keyword, organ in keyword_to_organ.items():
+        if keyword in indication_lower:
+            return organ
+            
+    # Use the 'areas' context for additional mapping
+    if areas:
+        areas_lower = str(areas).lower()
+        if 'digestive' in areas_lower:
+            if any(term in indication_lower for term in ['bowel', 'colon', 'rectal', 'intestin']):
+                return 'Bowel'
+            elif any(term in indication_lower for term in ['liver', 'hepat', 'biliary']):
+                return 'Liver'
+            elif 'pancrea' in indication_lower:
+                return 'Pancreas'
+            elif any(term in indication_lower for term in ['stomach', 'gastric', 'esophag']):
+                return 'Esophagus/Stomach'
+        elif 'respiratory' in areas_lower:
+            return 'Lung'
+        elif 'neurology' in areas_lower:
+            if 'peripheral' in indication_lower:
+                return 'Peripheral Nervous System'
+            else:
+                return 'CNS/Brain'
+        elif 'dermatology' in areas_lower:
+            return 'Skin'
+        elif 'oncology' in areas_lower:
+            # For oncology, need more specific organ information
+            if any(term in indication_lower for term in ['lung', 'pulmonary', 'bronch']):
+                return 'Lung'
+            elif any(term in indication_lower for term in ['brain', 'glioma', 'cerebr']):
+                return 'CNS/Brain'
+            elif any(term in indication_lower for term in ['liver', 'hepatic']):
+                return 'Liver'
+            elif any(term in indication_lower for term in ['skin', 'melanoma', 'basal cell']):
+                return 'Skin'
+            elif any(term in indication_lower for term in ['breast', 'mammary']):
+                return 'Breast'
+            elif any(term in indication_lower for term in ['colon', 'rectal', 'colorectal']):
+                return 'Bowel'
+            elif any(term in indication_lower for term in ['pancreas', 'pancreatic']):
+                return 'Pancreas'
+            elif any(term in indication_lower for term in ['kidney', 'renal']):
+                return 'Kidney'
+            elif any(term in indication_lower for term in ['bladder', 'urinary']):
+                return 'Bladder/Urinary Tract'
+            elif any(term in indication_lower for term in ['cervix', 'cervical']):
+                return 'Cervix'
+            elif any(term in indication_lower for term in ['uterus', 'uterine', 'endometri']):
+                return 'Uterus'
+            elif any(term in indication_lower for term in ['ovary', 'ovarian', 'fallopian']):
+                return 'Ovary/Fallopian Tube'
+            
+    # If no confident mapping is found, return None
+    return None
+
+def main():
+    # Load indications from TSV file
+    file_path = '../genetic_support/data/indic.tsv'  # Update this path if necessary
+    indications_df = load_indications(file_path)
+    indications_df = indications_df.dropna(subset=['indication_mesh_term'])
+    
+    if indications_df is not None:
+        # Add a new column for organ mapping
+        indications_df['organ'] = indications_df.apply(
+            lambda row: map_indication_to_organ(row['indication_mesh_term'], row.get('areas')), 
+            axis=1
+        )
+        
+        # Display indications with their mapped organs
+        mapped_df = indications_df[['indication_mesh_term', 'organ']]
+        all_mappings = mapped_df.copy()  # Save all mappings for reference
+        
+        # Show only confident mappings
+        mapped_df = mapped_df[mapped_df['organ'].notnull()]
+        
+        print(f"Successfully mapped {len(mapped_df)} out of {len(indications_df)} indications to organs.")
+        print(mapped_df.head(20))  # Display first 20 mappings
+        
+        # Save the results to CSV files
+        mapped_df.to_csv('indication_to_organ_mapping_confident.tsv', index=False, sep='\t')
+        all_mappings.to_csv('indication_to_organ_mapping_all.tsv', index=False, sep='\t')
+        print("Mappings saved to 'indication_to_organ_mapping_confident.tsv'")
+        
+        # Summary of organ distribution
+        if not mapped_df.empty:
+            organ_counts = mapped_df['organ'].value_counts()
+            print("\nDistribution of indications across organs:")
+            print(organ_counts)
+            
+            # Indications that couldn't be confidently mapped
+            unmapped = indications_df[indications_df['organ'].isnull()]
+            print(f"\nNumber of indications that couldn't be confidently mapped: {len(unmapped)}")
+
+if __name__ == "__main__":
+    main()

classifier.py

@@ -0,0 +1,293 @@
+import os
+import argparse
+import numpy as np
+import pandas as pd
+import matplotlib.pyplot as plt
+import seaborn as sns
+from sklearn.model_selection import train_test_split
+from sklearn.preprocessing import OneHotEncoder, StandardScaler
+from sklearn.metrics import roc_curve, auc, precision_recall_curve
+import statsmodels.api as sm
+# import warnings
+# warnings.filterwarnings('ignore')
+
+def load_data(file_path):
+    df = pd.read_csv(file_path, index_col=0)
+    return df
+
+def explore_data(df):
+    print("Dataset shape:", df.shape)
+    print("\nFeature data types:")
+    print(df.dtypes)
+    print("\nCheck for missing values:")
+    print(df.isnull().sum())
+    
+    # Check class balance for target variable
+    print("\nTarget variable distribution:")
+    target_dist = df['is_effective'].value_counts(normalize=True) * 100
+    print(target_dist)
+    
+    return df
+
+def analyze_feature_correlations(df):
+    numeric_cols = df.select_dtypes(include=['int64', 'float64']).columns.tolist()    
+    corr_matrix = df[numeric_cols].corr(method='spearman')
+    
+    #plt.figure(figsize=(5,5))
+    sns.heatmap(corr_matrix, annot=True, cmap='coolwarm', linewidths=0.5, fmt='.2f', annot_kws={"size": 8})
+    plt.title('Feature Correlation Matrix')
+    plt.tight_layout()
+    plt.savefig('feature_correlation_matrix.png', dpi=300, bbox_inches='tight')
+    plt.close()
+
+    # Show correlations with target variable
+    target_corr = corr_matrix['is_effective'].sort_values(ascending=False)
+    print("Correlations with target variable 'is_effective':")
+    print(target_corr)
+    
+    return corr_matrix
+
+def prepare_data(X, y, split_seed=42):
+    """
+    Prepare data for model training by scaling numeric features and encoding categorical features.
+    
+    Args:
+        X: DataFrame containing features. Expects indices to be drug-cell_line.
+        y: Series containing target variable
+        
+    Returns:
+        X_train, X_test, y_train, y_test: Train-test split of prepared data
+    """
+    
+    # Assert that indices of X and y are the same
+    assert X.index.equals(y.index), "X and y must have the same indices"
+    
+    # Extract drug and cell line info
+    drug_name = X.index.str.split('_CVCL_').str[0]
+    cell_line_name = 'CVCL_' + X.index.str.split('_CVCL_').str[1]
+    
+    cat_cols = X.select_dtypes(include=['object', 'category']).columns.tolist()
+    num_cols = X.select_dtypes(include=['int64', 'float64']).columns.tolist()
+    # Create a copy of X to avoid modifying the original
+    X_processed = X.copy()
+    
+    scaler = StandardScaler()
+    if num_cols:
+        X_processed[num_cols] = scaler.fit_transform(X_processed[num_cols])
+    
+    if cat_cols:
+        encoder = OneHotEncoder(sparse_output=False, handle_unknown='ignore', drop='first')
+        encoded_cats = encoder.fit_transform(X_processed[cat_cols])
+        feature_names = encoder.get_feature_names_out(cat_cols)
+        
+        encoded_df = pd.DataFrame(
+            encoded_cats, 
+            columns=feature_names,
+            index=X_processed.index
+        )
+        
+        X_processed = X_processed.drop(cat_cols, axis=1)
+        X_processed = pd.concat([X_processed, encoded_df], axis=1)
+    
+    # Split based on unique drugs to prevent data leakage
+    unique_drugs = drug_name.unique()
+    train_drugs, test_drugs = train_test_split(
+        unique_drugs, test_size=0.8, random_state=split_seed
+    )
+    
+    # Create train/test masks based on drug splits
+    train_mask = drug_name.isin(train_drugs)
+    test_mask = drug_name.isin(test_drugs)
+    
+    # Split the data
+    X_train, X_test = X_processed.loc[train_mask], X_processed.loc[test_mask]
+    y_train, y_test = y.loc[train_mask], y.loc[test_mask]
+    
+    # # Verify stratification is reasonable
+    # print(f"Train set positive rate: {y_train.mean():.4f}")
+    # print(f"Test set positive rate: {y_test.mean():.4f}")
+    
+    # print(f"Training set: {X_train.shape}")
+    # print(f"Testing set: {X_test.shape}")
+    
+    return X_train, X_test, y_train, y_test
+
+def evaluate_model(model, X_test, y_test):
+    """Evaluate model performance and return PR AUC score."""
+    X_test_const = sm.add_constant(X_test)    
+    y_prob = model.predict(X_test_const)
+    y_pred = (y_prob > 0.5).astype(int)    
+    
+    # Calculate ROC AUC for model
+    fpr, tpr, _ = roc_curve(y_test, y_prob)
+    roc_auc = auc(fpr, tpr)
+    print(f"\nROC AUC: {roc_auc:.4f}")
+    
+    # Calculate baseline ROC AUC (random classifier)
+    no_skill_prob = np.ones(len(y_test)) * np.mean(y_test)
+    fpr_baseline, tpr_baseline, _ = roc_curve(y_test, no_skill_prob)
+    roc_auc_baseline = auc(fpr_baseline, tpr_baseline)
+    print(f"Baseline ROC AUC: {roc_auc_baseline:.4f}")
+    
+    # Calculate PR AUC for model
+    precision, recall, _ = precision_recall_curve(y_test, y_prob)
+    pr_auc = auc(recall, precision)
+    print(f"PR AUC: {pr_auc:.4f}")
+    
+    # Calculate baseline PR AUC
+    no_skill = (y_test.sum()/y_test.shape[0])[0]
+    precision_baseline = np.ones_like(recall) * no_skill
+    pr_auc_baseline = auc(recall, precision_baseline)
+    print(f"Baseline PR AUC: {pr_auc_baseline:.4f}")
+    
+    # # ROC curve with baseline comparison
+    # plt.figure(figsize=(5,5))
+    # plt.plot(fpr, tpr, color='darkorange', lw=2, label=f'Model ROC (AUC = {roc_auc:.2f})')
+    # plt.plot(fpr_baseline, tpr_baseline, color='green', lw=2, linestyle='--', 
+    #          label=f'Baseline ROC (AUC = {roc_auc_baseline:.2f})')
+    # plt.plot([0, 1], [0, 1], color='navy', lw=2, linestyle='--')
+    # plt.xlim([0.0, 1.0])
+    # plt.ylim([0.0, 1.05])
+    # plt.xlabel('False Positive Rate')
+    # plt.ylabel('True Positive Rate')
+    # plt.title('Receiver Operating Characteristic')
+    # plt.legend(loc='lower right')
+    # plt.tight_layout()
+    # plt.savefig('roc_curve.png')
+    
+    # Plot Precision-Recall curve with baseline
+    plt.figure(figsize=(5,5))
+    plt.plot(recall, precision, color='blue', lw=2, 
+             label=f'Model (AUC = {pr_auc:.2f})')
+    plt.plot([0, 1], [no_skill, no_skill], linestyle='--', color='red', 
+             label=f'No Skill ({no_skill:.2f})')
+    plt.xlabel('Recall')
+    plt.ylabel('Precision')
+    plt.title('Precision-Recall Curve')
+    plt.legend()
+    plt.tight_layout()
+    plt.savefig('precision_recall_curve.png')
+ 
+    return y_pred, y_prob, pr_auc, pr_auc_baseline
+
+def train_linear_model(X_train, y_train, alpha=0.01):
+    X_train_const = sm.add_constant(X_train)    
+    final_logit = sm.Logit(y_train, X_train_const)
+    # Train model with L1 regularization (Lasso) and robust standard errors
+    final_model = final_logit.fit_regularized(
+        method='l1',
+        alpha=alpha,
+        cov_type='HC3',
+        trim_mode='auto',
+        maxiter=10_000
+    )
+    # Try L2 regularization (Ridge) if L1 fails to converge
+    if not hasattr(final_model, 'params'):
+        print("L1 regularization did not converge, trying L2...")
+        final_model = final_logit.fit_regularized(
+            method='l2',
+            alpha=alpha,
+            cov_type='HC3',
+            trim_mode='auto',
+            maxiter=10_000
+        )
+    train_pred_proba = final_model.predict(X_train_const)
+    train_precision, train_recall, _ = precision_recall_curve(y_train, train_pred_proba)
+    train_pr_auc = auc(train_recall, train_precision)
+    print(f"Model training Precision-Recall AUC: {train_pr_auc:.4f}")
+    fpr, tpr, _ = roc_curve(y_train, train_pred_proba)
+    train_roc_auc = auc(fpr, tpr)
+    print(f"Model training ROC AUC: {train_roc_auc:.4f}")
+    print(f"Regularization: alpha={alpha}")
+    return final_model
+
+def analyze_coefficients(model, feature_names):
+    feature_names = ['const'] + feature_names.tolist()
+    coefficients = model.params    
+    odds_ratios = np.exp(coefficients)
+    coef_df = pd.DataFrame({
+        'Feature': feature_names,
+        'Coefficient': coefficients,
+        'Odds_Ratio': odds_ratios,
+        'HC_Std_Error': model.bse,
+        'z_value': model.tvalues,
+        'p_value': model.pvalues,
+        'CI_Lower_95': model.conf_int(alpha=0.05).iloc[:, 0],
+        'CI_Upper_95': model.conf_int(alpha=0.05).iloc[:, 1]
+    })
+    
+    # Sort by absolute coefficient value (excluding constant)
+    coef_df['Abs_Coefficient'] = np.abs(coef_df['Coefficient'])
+    coef_df = coef_df.sort_values('Abs_Coefficient', ascending=False).drop('Abs_Coefficient', axis=1)
+    
+    # Add significance indicator
+    coef_df['Significant'] = coef_df['p_value'] < 0.05
+    
+    # Print top significant coefficients (excluding constant)
+    print("\nTop significant features (p < 0.05):")
+    sig_features = coef_df[coef_df['Significant'] & (coef_df['Feature'] != 'const')]
+    if len(sig_features) > 0:
+        print(sig_features.head(10)[['Feature', 'Coefficient', 'p_value', 'Odds_Ratio', 'CI_Lower_95', 'CI_Upper_95']])
+    else:
+        print("No statistically significant features found.")
+ 
+    # Count significant coefficients (excluding constant)
+    n_significant = sum(coef_df['Significant'] & (coef_df['Feature'] != 'const'))
+    n_features = sum(coef_df['Feature'] != 'const')
+    print(f"\nNumber of significant coefficients (p < 0.05): {n_significant} out of {n_features}")
+    
+    # Plot top coefficients with confidence intervals (excluding constant)
+    plt.figure(figsize=(5,5))
+    # Get top 15 features by absolute coefficient value (excluding constant)
+    top_coefs = coef_df[coef_df['Feature'] != 'const'].head(15)
+    # Plot coefficients with confidence intervals
+    colors = ['blue' if sig else 'gray' for sig in top_coefs['Significant']]
+    for i, (coef, ci_lower, ci_upper, color) in enumerate(zip(
+            top_coefs['Coefficient'], 
+            top_coefs['CI_Lower_95'], 
+            top_coefs['CI_Upper_95'],
+            colors)):
+        plt.errorbar(
+            x=coef,
+            y=i,
+            xerr=[[coef - ci_lower], [ci_upper - coef]],
+            fmt='o',
+            capsize=5,
+            color=color
+        )
+    # Add feature names as y-tick labels
+    plt.yticks(range(len(top_coefs)), top_coefs['Feature'])
+    plt.axvline(x=0, color='black', linestyle='-', alpha=0.3)
+    plt.title('Top Logistic Regression Coefficients with 95% CIs')
+    plt.xlabel('Coefficient Value')
+    plt.tight_layout()
+    plt.savefig('top_coefficients.png', dpi=300, bbox_inches='tight')
+    
+    return coef_df
+
+# def main():
+#     parser = argparse.ArgumentParser()
+#     parser.add_argument('--file_path', type=str, help='Path to the input CSV file')
+#     parser.add_argument('--output_dir', type=str, default='results', help='Directory to save results')
+#     args = parser.parse_args()
+
+#     if not os.path.exists(args.output_dir):
+#         os.makedirs(args.output_dir)
+    
+#     df = load_data(args.file_path)
+#     df = explore_data(df)    
+#     corr_matrix = analyze_feature_correlations(df)    
+#     X_train, X_test, y_train, y_test = prepare_data(df)    
+#     lr_model = train_linear_model(X_train, y_train)    
+#     lr_pred, lr_prob = evaluate_model(lr_model, X_test, y_test)    
+#     coef_df = analyze_coefficients(lr_model, X_train.columns)    
+    
+#     results = {
+#         'logistic_regression': lr_model,
+#         'lr_coefficients': coef_df,
+#     }
+    
+#     return results, df
+
+# if __name__ == "__main__":
+#     results, df = main()

clinical_data_curation/adverse_events_drug.py

@@ -0,0 +1,137 @@
+from typing import List
+import requests
+import pandas as pd
+import time
+
+from datasets import load_dataset
+from requests.adapters import HTTPAdapter
+from urllib3.util.retry import Retry
+
+# if getting bad gateway errors, try:
+# Retry session setup
+session = requests.Session()
+retries = Retry(
+    total=5,  # Retry up to 5 times
+    backoff_factor=1,  # Wait 1s, then 2s, then 4s...
+    status_forcelist=[502, 503, 504],
+    allowed_methods=["GET"],
+)
+session.mount("https://", HTTPAdapter(max_retries=retries))
+
+
+def get_faers_adverse_events(drug_name: str, limit: int = 100) -> List:
+    """
+    Fetch and parse adverse event reports for a drug from openFDA FAERS.
+    Adds serious outcome flags and event context fields.
+    Args:
+        drug_name (str): The name of the drug to search for.
+        limit (int): The maximum number of records to fetch.
+    Returns:
+        List: A list of dictionaries containing adverse event data.
+    """
+    print(f"Fetching FAERS data for: {drug_name}")
+    url = "https://api.fda.gov/drug/event.json"
+    params = {"search": f'patient.drug.medicinalproduct:"{drug_name}"', "limit": limit}
+
+    try:
+        response = requests.get(url, params=params, timeout=10)
+        response.raise_for_status()
+        results = response.json().get("results", [])
+
+        # Extract detailed adverse event fields
+        events = []
+        for entry in results:
+            patient = entry.get("patient", {})
+            reactions = [r.get("reactionmeddrapt") for r in patient.get("reaction", [])]
+
+            event = {
+                "drug_name": drug_name,
+                "safetyreportid": entry.get("safetyreportid"),
+                "serious": entry.get("serious"),
+                "seriousnessdeath": entry.get("seriousnessdeath"),
+                "seriousnesshospitalization": entry.get("seriousnesshospitalization"),
+                "seriousnessdisabling": entry.get("seriousnessdisabling"),
+                "seriousnesslifethreatening": entry.get("seriousnesslifethreatening"),
+                "seriousnesscongenitalanomali": entry.get("seriousnesscongenitalanomali"),
+                "reactions": reactions,
+                "receivedate": entry.get("receivedate"),
+                "occurcountry": entry.get("occurcountry"),
+            }
+            events.append(event)
+        print(f"Fetched {len(events)} events for {drug_name}")
+
+        return events
+
+    except requests.exceptions.RequestException as e:
+        print(f"Failed to fetch data for {drug_name}: {e}")
+        return []
+
+
+def pull_faers_data(drug_list: List[str], output_filename_prefix: str) -> pd.DataFrame:
+    """
+    Pull FAERS data for a list of drugs and save to CSV.
+    Args:
+        drug_list (List[str]): List of drug names to fetch data for.
+    """
+    all_events = []
+    for drug in drug_list:
+        events = get_faers_adverse_events(drug, limit=100)
+        all_events.extend(events)
+        time.sleep(1)  # be polite to openFDA rate limits
+
+    # Convert to DataFrame and show or save
+    df = pd.DataFrame(all_events)
+    df.to_csv(f"{output_filename_prefix}_faers_adverse_events.csv", index=False)
+    print(df.head(), df.shape)
+    return df
+
+
+# example drug list
+drug_list = ["pembrolizumab", "nivolumab", "ipilimumab"]
+
+# test out fx
+pull_faers_data(drug_list=drug_list, output_filename_prefix="test")
+
+
+# load tahoe drug data metadata, gather the AEs for each unique drug
+ds = load_dataset("tahoebio/Tahoe-100M", "drug_metadata")
+drug_metadata = ds["train"].to_pandas()
+
+# get adverse events for each unique drug in the tahoe dataset
+tahoe_drug_list = drug_metadata["drug"].unique().tolist()
+adverse_events = pull_faers_data(drug_list=tahoe_drug_list, output_filename_prefix="tahoe_drugs")
+# adverse_events = pd.read_csv("tahoe_drugs_faers_adverse_events.csv")
+
+# summarize the adverse events for each drug so we can try to predict the severity of a drug
+def compute_severity_score(df: pd.DataFrame) -> float:
+    weights = {
+        "seriousnessdeath": 5,
+        "seriousnesslifethreatening": 4,
+        "seriousnesshospitalization": 3,
+        "seriousnessdisabling": 2,
+        "seriousnesscongenitalanomali": 1,
+    }
+    score = 0
+    for k, w in weights.items():
+        score += df[k].fillna("0").astype(int).sum() * w
+    return score
+
+
+def compute_seriousness_ratio(df: pd.DataFrame) -> float:
+    """
+    Compute the ratio of serious to non-serious adverse events.
+    """
+    seriousness_ae_ratio = (
+        df.groupby("drug_name")["serious"]
+        .apply(lambda x: x.fillna("0").astype(int).mean())
+        .reset_index(name="mean_serious_flag")
+    )
+    return seriousness_ae_ratio
+
+
+ae_score_df = adverse_events.groupby("drug_name").apply(compute_severity_score).reset_index(name="ae_severity_score")
+seriousness_ratio = compute_seriousness_ratio(adverse_events)
+
+# write out outputs
+ae_score_df.to_csv("tahoe_drug_ae_severity_score.csv", index=False)
+seriousness_ratio.to_csv("tahoe_drug_ae_seriousness_ratio.csv", index=False)

clinical_data_curation/drug_trials_extractor.py

@@ -0,0 +1,707 @@
+import os
+import requests
+import pandas as pd
+import json
+import time
+import re
+from typing import List, Dict, Any, Union, Optional
+
+import anthropic
+
+class DrugTrialExtractor:
+    """
+    A class to extract information about which drugs are in clinical trials and their indications
+    using PubChem IDs and clinical trials data sources.
+    """
+    
+    def __init__(self):
+        # Base URLs for APIs
+        self.pubchem_base_url = "https://pubchem.ncbi.nlm.nih.gov/rest/pug"
+        self.pubchem_view_url = "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound"
+        self.clinicaltrials_api_url = "https://clinicaltrials.gov/api/v2/studies"
+        
+        # For rate limiting
+        self.request_delay = 0.5  # seconds between API requests
+    
+    def get_drug_info_from_pubchem(self, pubchem_id: str) -> Dict[str, Any]:
+        """
+        Get basic drug information from PubChem using a PubChem ID (CID)
+        
+        Parameters:
+        -----------
+        pubchem_id : str
+            The PubChem Compound ID (CID)
+            
+        Returns:
+        --------
+        Dict[str, Any]
+            Dictionary with drug information
+        """
+        try:
+            # Validate the PubChem ID format
+            try:
+                # Ensure it's numeric and can be converted to integer
+                int(pubchem_id)
+            except ValueError:
+                return {
+                    "pubchem_id": pubchem_id, 
+                    "error": "Invalid PubChem ID format - must be numeric"
+                }
+            
+            # First check if the compound exists with a simple request
+            check_url = f"{self.pubchem_base_url}/compound/cid/{pubchem_id}/cids/JSON"
+            check_response = requests.get(check_url)
+            
+            if check_response.status_code != 200:
+                error_msg = f"Error code {check_response.status_code}"
+                if check_response.status_code == 400:
+                    error_msg = "PubChem ID doesn't exist or has been deprecated"
+                elif check_response.status_code == 404:
+                    error_msg = "PubChem ID not found"
+                elif check_response.status_code == 429:
+                    error_msg = "Rate limit exceeded - try again later"
+                    
+                return {"pubchem_id": pubchem_id, "error": error_msg}
+            
+            # Get drug properties (name, formula, etc.)
+            property_url = f"{self.pubchem_base_url}/compound/cid/{pubchem_id}/property/IUPACName,MolecularFormula,MolecularWeight,CanonicalSMILES/JSON"
+            property_response = requests.get(property_url)
+            
+            if property_response.status_code != 200:
+                print(f"Error retrieving properties for PubChem ID {pubchem_id}: {property_response.status_code}")
+                print(f"Response: {property_response.text}")
+                return {"pubchem_id": pubchem_id, "error": "Failed to retrieve properties"}
+            
+            property_data = property_response.json()
+            
+            # Add delay to respect rate limits
+            time.sleep(self.request_delay)
+            
+            # Get synonyms to find common drug names
+            synonyms_url = f"{self.pubchem_base_url}/compound/cid/{pubchem_id}/synonyms/JSON"
+            synonyms_response = requests.get(synonyms_url)
+            
+            if synonyms_response.status_code != 200:
+                print(f"Error retrieving synonyms for PubChem ID {pubchem_id}: {synonyms_response.status_code}")
+                synonyms = []
+            else:
+                synonyms_data = synonyms_response.json()
+                synonyms = synonyms_data.get("InformationList", {}).get("Information", [{}])[0].get("Synonym", [])
+            
+            # Add delay to respect rate limits
+            time.sleep(self.request_delay)
+            
+            # Compile the drug information
+            props = property_data.get("PropertyTable", {}).get("Properties", [{}])[0]
+            
+            # Find the common name (usually a drug name) from synonyms
+            # This is heuristic-based and prioritizes known drug name patterns
+            common_name = None
+            drug_name_candidates = []
+            
+            if synonyms:
+                for syn in synonyms:
+                    # Skip very long names and suspected CAS numbers or identifiers
+                    if len(syn) > 50 or bool(re.match(r'^\d+-\d+-\d+$', syn)):
+                        continue
+                        
+                    # Prioritize names that look like drug names (no special chars, not too long)
+                    if len(syn) < 20 and syn.isalpha() and syn[0].isupper():
+                        drug_name_candidates.append(syn)
+                
+                # Sort by length (shorter names first)
+                drug_name_candidates.sort(key=len)
+                
+                if drug_name_candidates:
+                    common_name = drug_name_candidates[0]
+                else:
+                    # Fallback to any reasonable synonym
+                    sorted_synonyms = sorted([s for s in synonyms if len(s) < 30], key=len)
+                    if sorted_synonyms:
+                        common_name = sorted_synonyms[0]
+            
+            drug_info = {
+                "pubchem_id": pubchem_id,
+                "iupac_name": props.get("IUPACName", ""),
+                "common_name": common_name,
+                "molecular_formula": props.get("MolecularFormula", ""),
+                "molecular_weight": props.get("MolecularWeight", ""),
+                "canonical_smiles": props.get("CanonicalSMILES", ""),
+                "synonyms": synonyms[:10] if len(synonyms) > 10 else synonyms  # Limit to 10 synonyms
+            }
+            
+            return drug_info
+            
+        except Exception as e:
+            print(f"Error in get_drug_info_from_pubchem for ID {pubchem_id}: {str(e)}")
+            return {"pubchem_id": pubchem_id, "error": str(e)}
+    
+    def get_clinical_trials_sections(self, pubchem_id: str) -> Optional[Dict[str, Any]]:
+        """
+        Get the clinical trials sections from PubChem for a given compound
+        
+        Parameters:
+        -----------
+        pubchem_id : str
+            The PubChem Compound ID (CID)
+            
+        Returns:
+        --------
+        Optional[Dict[str, Any]]
+            Dictionary with clinical trials sections or None if not found
+        """
+        try:
+            # Using PUG-View to get the clinical trials sections
+            url = f"{self.pubchem_view_url}/{pubchem_id}/JSON?response_type=display"
+            response = requests.get(url)
+            
+            if response.status_code != 200:
+                print(f"Error retrieving clinical trials sections for PubChem ID {pubchem_id}: {response.status_code}")
+                return None
+            
+            data = response.json()
+            
+            # Navigate through the JSON to find the clinical trials section
+            record = data.get("Record", {})
+            section = record.get("Section", [])
+            
+            clinical_trials_data = None
+            
+            # Look for "Drug and Medication Information" section
+            for s in section:
+                if s.get("TOCHeading") == "Drug and Medication Information":
+                    drug_section = s.get("Section", [])
+                    for ds in drug_section:
+                        if ds.get("TOCHeading") == "Clinical Trials":
+                            clinical_trials_data = ds
+                            break
+                    break
+            
+            return clinical_trials_data
+            
+        except Exception as e:
+            print(f"Error in get_clinical_trials_sections for ID {pubchem_id}: {str(e)}")
+            return None
+    
+    def extract_trials_from_pubchem(self, pubchem_id: str) -> List[Dict[str, Any]]:
+        """
+        Extract clinical trials information from PubChem for a given compound ID
+        
+        Parameters:
+        -----------
+        pubchem_id : str
+            The PubChem Compound ID (CID)
+            
+        Returns:
+        --------
+        List[Dict[str, Any]]
+            List of dictionaries with clinical trial information
+        """
+        clinical_trials_section = self.get_clinical_trials_sections(pubchem_id)
+        
+        if not clinical_trials_section:
+            return []
+        
+        trial_list = []
+        
+        # Process the clinical trials section to extract trials information
+        try:
+            section_list = clinical_trials_section.get("Section", [])
+            
+            for section in section_list:
+                source_name = section.get("TOCHeading", "Unknown Source")
+                
+                # Look for information about trials in this source
+                info_list = section.get("Information", [])
+                
+                for info in info_list:
+                    if "ExternalTableName" in info.get("Value", {}):
+                        # This means there are trials in this source
+                        trial_list.append({
+                            "pubchem_id": pubchem_id,
+                            "source": source_name,
+                            "has_trials": True,
+                            "trial_count": info.get("Value", {}).get("ExternalTableNumRows", "Unknown")
+                        })
+        
+        except Exception as e:
+            print(f"Error extracting trials from PubChem for ID {pubchem_id}: {str(e)}")
+        
+        return trial_list
+        
+    def search_clinicaltrials_gov(self, drug_name: str, max_results: int = 100) -> List[Dict[str, Any]]:
+        """
+        Search ClinicalTrials.gov for trials involving a specific drug
+        
+        Parameters:
+        -----------
+        drug_name : str
+            The name of the drug to search for
+        max_results : int, optional
+            Maximum number of results to return (default 100)
+            
+        Returns:
+        --------
+        List[Dict[str, Any]]
+            List of dictionaries with clinical trial information
+        """
+        try:
+            # Skip names that are too long or complex as they'll likely cause a 400 error
+            if len(drug_name) > 150 or drug_name.count('[') > 2:
+                print(f"Skipping search for complex name: {drug_name}")
+                return []
+                
+            # Using the new ClinicalTrials.gov API v2
+            params = {
+                "query.term": drug_name,
+                "pageSize": min(max_results, 100)  # API limits to 1000 per request
+            }
+            
+            trials = []
+            
+            # Make initial request
+            response = requests.get(self.clinicaltrials_api_url, params=params)
+            
+            if response.status_code != 200:
+                print(f"Error searching ClinicalTrials.gov for {drug_name}: {response.status_code}")
+                if response.status_code == 400:
+                    # If it's a 400 Bad Request, the drug name is likely invalid for the API
+                    print(f"Drug name '{drug_name}' is not valid for the ClinicalTrials.gov API.")
+                return []
+            
+            data = response.json()
+            studies = data.get('studies', [])
+            
+            # Process all studies from the first page
+            for study in studies:
+                try:
+                    # Extract the protocol section which contains most of the important information
+                    protocol = study.get("protocolSection", {})
+                    
+                    # Extract identification information
+                    identification = protocol.get("identificationModule", {})
+                    nct_id = identification.get("nctId", "Unknown")
+                    brief_title = identification.get("briefTitle", "Unknown")
+                    
+                    # Extract status information
+                    status_module = protocol.get("statusModule", {})
+                    overall_status = status_module.get("overallStatus", "Unknown")
+                    
+                    # FIXED: Extract phase information from designModule.phases array
+                    design_module = protocol.get("designModule", {})
+                    phases = design_module.get("phases", [])
+                    phase = phases[0] if phases else "Unknown"
+                    
+                    # Extract conditions
+                    conditions_module = protocol.get("conditionsModule", {})
+                    conditions = conditions_module.get("conditions", [])
+                    
+                    # Extract interventions (drugs, etc.)
+                    interventions = []
+                    intervention_module = protocol.get("armsInterventionsModule", {})
+                    intervention_list = intervention_module.get("interventions", [])
+                    
+                    for intervention in intervention_list:
+                        intervention_name = intervention.get("name", "")
+                        intervention_type = intervention.get("type", "")
+                        intervention_description = intervention.get("description", "")
+                        
+                        interventions.append({
+                            "name": intervention_name,
+                            "type": intervention_type,
+                            "description": intervention_description
+                        })
+                    
+                    # Create a dictionary for this trial
+                    trial_info = {
+                        "nct_id": nct_id,
+                        "title": brief_title,
+                        "status": overall_status,
+                        "phase": phase,
+                        "conditions": conditions,
+                        "interventions": interventions
+                    }
+                    
+                    trials.append(trial_info)
+                    
+                except Exception as e:
+                    print(f"Error processing study {study.get('protocolSection', {}).get('identificationModule', {}).get('nctId', 'Unknown')}: {str(e)}")
+            
+            # Check if there are more pages
+            next_page_token = data.get("nextPageToken")
+            
+            # Continue getting data if there's a next page and we haven't reached max_results
+            while next_page_token and len(trials) < max_results:
+                # Add delay to respect rate limits
+                time.sleep(self.request_delay)
+                
+                # Update parameters with the next page token
+                params["pageToken"] = next_page_token
+                
+                # Make the request for the next page
+                response = requests.get(self.clinicaltrials_api_url, params=params)
+                
+                if response.status_code != 200:
+                    print(f"Error retrieving next page for {drug_name}: {response.status_code}")
+                    break
+                
+                data = response.json()
+                studies = data.get("studies", [])
+                
+                # Process all studies from this page
+                for study in studies:
+                    if len(trials) >= max_results:
+                        break
+                        
+                    try:
+                        # Extract the protocol section
+                        protocol = study.get("protocolSection", {})
+                        
+                        # Extract identification information
+                        identification = protocol.get("identificationModule", {})
+                        nct_id = identification.get("nctId", "Unknown")
+                        brief_title = identification.get("briefTitle", "Unknown")
+                        
+                        # Extract status information
+                        status_module = protocol.get("statusModule", {})
+                        overall_status = status_module.get("overallStatus", "Unknown")
+                        
+                        # FIXED: Extract phase information from designModule.phases array
+                        design_module = protocol.get("designModule", {})
+                        phases = design_module.get("phases", [])
+                        phase = phases[0] if phases else "Unknown"
+                        
+                        # Extract conditions
+                        conditions_module = protocol.get("conditionsModule", {})
+                        conditions = conditions_module.get("conditions", [])
+                        
+                        # Extract interventions (drugs, etc.)
+                        interventions = []
+                        intervention_module = protocol.get("armsInterventionsModule", {})
+                        intervention_list = intervention_module.get("interventions", [])
+                        
+                        for intervention in intervention_list:
+                            intervention_name = intervention.get("name", "")
+                            intervention_type = intervention.get("type", "")
+                            intervention_description = intervention.get("description", "")
+                            
+                            interventions.append({
+                                "name": intervention_name,
+                                "type": intervention_type,
+                                "description": intervention_description
+                            })
+                        
+                        # Create a dictionary for this trial
+                        trial_info = {
+                            "nct_id": nct_id,
+                            "title": brief_title,
+                            "status": overall_status,
+                            "phase": phase,
+                            "conditions": conditions,
+                            "interventions": interventions
+                        }
+                        
+                        trials.append(trial_info)
+                        
+                    except Exception as e:
+                        print(f"Error processing study {study.get('protocolSection', {}).get('identificationModule', {}).get('nctId', 'Unknown')}: {str(e)}")
+                
+                # Update the next page token for the next iteration
+                next_page_token = data.get("nextPageToken")
+            
+            return trials
+            
+        except Exception as e:
+            print(f"Error in search_clinicaltrials_gov for drug {drug_name}: {str(e)}")
+            return []
+    
+    def get_trials_for_drug(self, pubchem_id: str, max_results: int = 100) -> Dict[str, Any]:
+        """
+        Get complete clinical trial information for a drug with the given PubChem ID
+        
+        Parameters:
+        -----------
+        pubchem_id : str
+            The PubChem Compound ID (CID)
+        max_results : int, optional
+            Maximum number of clinical trials to retrieve per drug (default 100)
+            
+        Returns:
+        --------
+        Dict[str, Any]
+            Dictionary with drug information and associated clinical trials
+        """
+        # Get drug information
+        drug_info = self.get_drug_info_from_pubchem(pubchem_id)
+        
+        # Check if PubChem has clinical trials information
+        pubchem_trials_info = self.extract_trials_from_pubchem(pubchem_id)
+        
+        # Search ClinicalTrials.gov using drug names
+        trials = []
+        
+        # Try with common name first as it's most likely to work
+        if drug_info.get("common_name"):
+            print(f"Searching ClinicalTrials.gov for common name: {drug_info['common_name']}")
+            trials.extend(self.search_clinicaltrials_gov(drug_info["common_name"], max_results))
+        
+        # Try with a filtered list of synonyms (prioritizing drug names over chemical identifiers)
+        if len(trials) < max_results and drug_info.get("synonyms"):
+            drug_synonyms = []
+            for synonym in drug_info.get("synonyms", []):
+                # Skip long and complex names, molecular identifiers, and registry numbers
+                if (len(synonym) < 30 and 
+                    not any(char in synonym for char in "[](){}-=") and
+                    not synonym.isdigit() and
+                    not bool(re.match(r'^\d+-\d+-\d+$', synonym))):  # Skip CAS registry numbers
+                    drug_synonyms.append(synonym)
+            
+            # Prioritize shorter names as they're more likely to be common drug names
+            drug_synonyms.sort(key=len)
+            
+            # Try up to 3 prioritized synonyms
+            for synonym in drug_synonyms[:3]:
+                if len(trials) >= max_results:
+                    break
+                
+                print(f"Searching ClinicalTrials.gov for synonym: {synonym}")
+                try:
+                    more_trials = self.search_clinicaltrials_gov(synonym, max_results - len(trials))
+                    
+                    # Filter to avoid duplicates
+                    existing_nct_ids = {t["nct_id"] for t in trials}
+                    for trial in more_trials:
+                        if trial["nct_id"] not in existing_nct_ids:
+                            trials.append(trial)
+                            existing_nct_ids.add(trial["nct_id"])
+                except Exception as e:
+                    print(f"Error searching for synonym {synonym}: {str(e)}")
+        
+        # As a last resort, try with IUPAC name (least likely to work with clinical trials API)
+        if len(trials) < max_results and len(trials) == 0 and drug_info.get("iupac_name"):
+            # Only use IUPAC name if it's reasonably short
+            if len(drug_info["iupac_name"]) < 100:  # Avoid extremely long IUPAC names
+                print(f"Searching ClinicalTrials.gov for IUPAC name: {drug_info['iupac_name']}")
+                try:
+                    more_trials = self.search_clinicaltrials_gov(drug_info["iupac_name"], max_results - len(trials))
+                    
+                    # Filter to avoid duplicates
+                    existing_nct_ids = {t["nct_id"] for t in trials}
+                    for trial in more_trials:
+                        if trial["nct_id"] not in existing_nct_ids:
+                            trials.append(trial)
+                            existing_nct_ids.add(trial["nct_id"])
+                except Exception as e:
+                    print(f"Error searching for IUPAC name: {str(e)}")
+        
+        # Compile results
+        result = {
+            "drug_info": drug_info,
+            "pubchem_trials_info": pubchem_trials_info,
+            "clinicaltrials_gov_trials": trials,
+        }
+        
+        return result
+    
+    def process_multiple_drugs(self, pubchem_ids: List[str], max_results_per_drug: int = 100) -> Dict[str, List[Dict[str, Any]]]:
+        """
+        Process multiple drugs and get their clinical trial information
+        
+        Parameters:
+        -----------
+        pubchem_ids : List[str]
+            List of PubChem Compound IDs (CIDs)
+        max_results_per_drug : int, optional
+            Maximum number of clinical trials to retrieve per drug (default 100)
+            
+        Returns:
+        --------
+        Dict[str, List[Dict[str, Any]]]
+            Dictionary with results for each drug
+        """
+        results = {}
+        
+        for pubchem_id in pubchem_ids:
+            print(f"Processing PubChem ID: {pubchem_id}")
+            drug_results = self.get_trials_for_drug(pubchem_id, max_results_per_drug)
+            results[pubchem_id] = drug_results
+            
+            # Add delay to respect rate limits
+            time.sleep(self.request_delay)
+        
+        return results
+    
+    def save_results_to_csv(self, results: Dict[str, Any], output_prefix: str = "drug_trials") -> Dict[str, str]:
+        """
+        Save the results to CSV files
+        
+        Parameters:
+        -----------
+        results : Dict[str, Any]
+            Results from process_multiple_drugs
+        output_prefix : str, optional
+            Prefix for output CSV files (default "drug_trials")
+            
+        Returns:
+        --------
+        Dict[str, str]
+            Dictionary with paths to the output files
+        """
+        # Create DataFrames
+        drug_info_rows = []
+        all_trials = []
+        pubchem_trials_rows = []
+        
+        for pubchem_id, drug_data in results.items():
+            # Add drug info
+            drug_info = drug_data.get("drug_info", {})
+            drug_info_rows.append(drug_info)
+            
+            # Add PubChem trials info
+            for trial_info in drug_data.get("pubchem_trials_info", []):
+                pubchem_trials_rows.append(trial_info)
+            
+            # Add ClinicalTrials.gov trials
+            for trial in drug_data.get("clinicaltrials_gov_trials", []):
+                trial_copy = trial.copy()
+                
+                # Add drug info to the trial
+                trial_copy["pubchem_id"] = pubchem_id
+                trial_copy["drug_name"] = drug_info.get("common_name", drug_info.get("iupac_name", ""))
+                
+                # Convert lists to strings for CSV
+                if "conditions" in trial_copy:
+                    trial_copy["conditions"] = "; ".join(trial_copy["conditions"])
+                
+                if "interventions" in trial_copy:
+                    interventions_list = trial_copy["interventions"]
+                    intervention_strings = []
+                    
+                    for intervention in interventions_list:
+                        int_str = f"{intervention.get('name', '')} ({intervention.get('type', '')})"
+                        intervention_strings.append(int_str)
+                    
+                    trial_copy["interventions"] = "; ".join(intervention_strings)
+                
+                all_trials.append(trial_copy)
+        
+        # Create DataFrames
+        drug_info_df = pd.DataFrame(drug_info_rows)
+        trials_df = pd.DataFrame(all_trials)
+        pubchem_trials_df = pd.DataFrame(pubchem_trials_rows)
+        
+        # Save to CSV
+        drug_info_path = f"{output_prefix}_drug_info.csv"
+        trials_path = f"{output_prefix}_clinical_trials.csv"
+        pubchem_trials_path = f"{output_prefix}_pubchem_trials_info.csv"
+        
+        drug_info_df.to_csv(drug_info_path, index=False)
+        trials_df.to_csv(trials_path, index=False)
+        pubchem_trials_df.to_csv(pubchem_trials_path, index=False)
+        
+        return {
+            "drug_info": drug_info_path,
+            "clinical_trials": trials_path,
+            "pubchem_trials_info": pubchem_trials_path
+        }
+
+# In your shared code:
+def get_anthropic_client():
+    # Get API key from environment variable
+    api_key = os.environ.get("ANTHROPIC_API_KEY")
+    
+    if not api_key:
+        raise ValueError("Missing ANTHROPIC_API_KEY environment variable")
+        
+    return anthropic.Anthropic(api_key=api_key)
+
+def standardize_medical_conditions(disease_list):
+    """
+    Standardizes a list of medical conditions using Claude API to identify and group similar conditions.
+    
+    Args:
+        disease_list (list): List of medical condition strings to standardize
+        api_key (str): Your Anthropic API key
+        
+    Returns:
+        pandas.DataFrame: DataFrame with original conditions and their standardized labels
+    """
+    # Initialize the Claude client
+    client = get_anthropic_client()
+    
+    # Create chunks if your list is very large (Claude has context limits)
+    chunk_size = 50  # Adjust based on your needs
+    all_groups = {}
+    
+    # Remove duplicates to reduce API costs while processing
+    unique_diseases = list(set(disease_list))
+    
+    for i in range(0, len(unique_diseases), chunk_size):
+        chunk = unique_diseases[i:i+chunk_size]
+        
+        # Format the prompt for Claude
+        formatted_diseases = "\n".join([f"- {d}" for d in chunk])
+        
+        prompt = f"""
+        Here's a list of medical conditions:
+        {formatted_diseases}
+        
+        Please group these conditions into standardized categories where entries refer to the same basic condition. 
+        For each group, select the most appropriate, specific, and concise label.
+        
+        IMPORTANT: Only group conditions when there's a clear case for doing so. When a condition is unique or 
+        doesn't clearly fit with others, keep it as its own separate category.
+        
+        Examples:
+        - "Prostate Cancer" and "Prostate Cancer; Prostate Adenocarcinoma" can be grouped as "Prostate Cancer"
+        - But "Small Cell Lung Cancer" should NOT be grouped with "Non-Small Cell Lung Cancer" as they are distinct conditions
+        - "Diabetes" and "Diabetes Mellitus Type 2" can be grouped, but should use the more specific "Diabetes Mellitus Type 2" as the label
+        
+        Format your response as a JSON dictionary where keys are the standardized labels and values are 
+        lists of all original terms that should map to that label. Include every term from the input list.
+        """
+        
+        # Call Claude API
+        message = client.messages.create(
+            model="claude-3-7-sonnet-20250219",
+            max_tokens=4000,
+            temperature=0,  # Keep it deterministic
+            system="You are a medical terminology expert. Follow instructions exactly.",
+            messages=[
+                {"role": "user", "content": prompt}
+            ]
+        )
+        
+        # Extract JSON from response
+        response_content = message.content[0].text
+        json_match = re.search(r'```(?:json)?\s*([\s\S]*?)\s*```', response_content)
+        
+        if json_match:
+            json_str = json_match.group(1)
+        else:
+            # If no code block, try to find JSON directly
+            json_str = response_content
+        
+        try:
+            chunk_groups = json.loads(json_str)
+            all_groups.update(chunk_groups)
+        except json.JSONDecodeError:
+            print(f"Warning: Could not parse JSON for chunk {i}. Skipping this chunk.")
+            continue
+    
+    # Convert to a mapping dictionary
+    condition_mapping = {}
+    for standard_label, variants in all_groups.items():
+        for variant in variants:
+            condition_mapping[variant] = standard_label
+    
+    # Apply mapping to original list (preserving order and duplicates)
+    mapped_diseases = [condition_mapping.get(disease, disease) for disease in disease_list]
+    
+    # Create a DataFrame with the results
+    result_df = pd.DataFrame({
+        "Original": disease_list,
+        "Standardized": mapped_diseases
+    })
+    
+    return result_df

clinical_data_curation/drugs_organs_approved.csv

@@ -0,0 +1,377 @@
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clinical_evidence_data/adverse_events_FDA_data/tahoe_drug_ae_seriousness_ratio.csv

@@ -0,0 +1,300 @@
+drug_name,mean_serious_flag
+5-Azacytidine,1.01
+5-Fluorouracil,1.13
+8-Hydroxyquinoline,1.1428571428571428
+9-ING-41,1.0
+Abemaciclib,1.34
+Abiraterone acetate,1.01
+Acetazolamide,1.09
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+Adenine,1.12
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+Allopurinol,1.62
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+Alpelisib,1.42
+Altretamine,1.1
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+Anastrozole,1.12
+Anethole trithione,1.02
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+Artemether,1.06
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+Asciminib,1.07
+Aspirin,1.34
+Ataluren,1.631578947368421
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+Auranofin,1.1237113402061856
+Azithromycin (hydrate),1.0169491525423728
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+Busulfan,1.01
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+Capivasertib,1.13
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+vincristine,1.01

clinical_evidence_data/adverse_events_FDA_data/tahoe_drug_ae_severity_score.csv

@@ -0,0 +1,300 @@
+drug_name,ae_severity_score
+5-Azacytidine,371
+5-Fluorouracil,285
+8-Hydroxyquinoline,54
+9-ING-41,8
+Abemaciclib,275
+Abiraterone acetate,250
+Acetazolamide,218
+Acetohexamide,11
+Adagrasib,2380
+Adenine,417
+Adenosine,257
+Afatinib,306
+Aliskiren,310
+Allantoin,1400
+Allopurinol,55
+Almonertinib (mesylate),57
+Alpelisib,341
+Altretamine,238
+Amsacrine,431
+Anastrozole,186
+Anethole trithione,478
+Apalutamide,301
+Aprepitant,320
+Arbutin,200
+Artemether,570
+Artesunate,289
+Asciminib,1653
+Aspirin,167
+Ataluren,273
+Atazanavir (sulfate),136
+Auranofin,326
+Azithromycin (hydrate),171
+Baicalin,34
+Belinostat,1895
+Belumosudil,2846
+Belumosudil (mesylate),2785
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+Bendamustine,340
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+Bestatin,151
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+Bexarotene,175
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+Binimetinib,416
+Bisoprolol (hemifumarate),270
+Bortezomib,208
+Bosentan (hydrate),117
+Brimonidine,6
+Brivudine,1301
+Budesonide,250
+Busulfan,242
+Cabozantinib (S-malate),1570
+Canagliflozin,183
+Canagliflozin (hemihydrate),144
+Capivasertib,2569
+Capmatinib,1138
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clinical_evidence_data/drugs_organs_approved.csv

@@ -0,0 +1,377 @@
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clinical_evidence_data/tahoe_drugs_clinical_trials.csv

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data/cell_line_metadata.csv

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+,cell_name,Cell_ID_DepMap,Cell_ID_Cellosaur,Organ,Driver_Gene_Symbol,Driver_VarZyg,Driver_VarType,Driver_ProtEffect_or_CdnaEffect,Driver_Mech_InferDM,Driver_GeneType_DM
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+1,A549,ACH-000681,CVCL_0023,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+2,A549,ACH-000681,CVCL_0023,Lung,KRAS,Hom,Missense,p.G12S,GoF,Oncogene
+3,A549,ACH-000681,CVCL_0023,Lung,SMARCA4,Hom,Frameshift,p.Q729fs,LoF,Suppressor
+4,A549,ACH-000681,CVCL_0023,Lung,STK11,Hom,Stopgain,p.Q37*,LoF,Suppressor
+5,A549,ACH-000681,CVCL_0023,Lung,ZFHX3,Het,Missense,p.L1473F,,Suppressor
+6,HOP-92,ACH-000825,CVCL_1286,Lung,ACVR2A,Het,Missense,p.K133M,LoF,Suppressor
+7,HOP-92,ACH-000825,CVCL_1286,Lung,GNAS,Het,Missense,p.V117M,,Oncogene
+8,HOP-92,ACH-000825,CVCL_1286,Lung,NF1,Het,Frameshift,p.M799fs,LoF,Suppressor
+9,HOP-92,ACH-000825,CVCL_1286,Lung,SOS1,Het,Missense,p.N233Y,GoF,Oncogene
+10,HOP-92,ACH-000825,CVCL_1286,Lung,TP53,Hom,Missense,p.R175L,LoF,Suppressor
+11,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,B2M,Hom,Deletion,DEL,LoF,Suppressor
+12,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,BRAF,Het,Missense,p.G469V,GoF,Oncogene
+13,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,BRCA2,Het,Missense,p.M784V,,Suppressor
+14,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+15,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,RB1,Het,Missense,p.L819V,,Suppressor
+16,HMVII,ACH-002040,CVCL_1282,Vulva/Vagina,TP53,Het,Missense,p.N268I,LoF,Suppressor
+17,Hs 936.T(C1),,CVCL_1034,Skin,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+18,MM485,ACH-001973,CVCL_2610,Skin,APC,Het,Missense,p.P2783S,LoF,Suppressor
+19,MM485,ACH-001973,CVCL_2610,Skin,CDKN2A,Hom,Stopgain,p.W59*,LoF,Suppressor
+20,MM485,ACH-001973,CVCL_2610,Skin,NRAS,Het,Missense,p.Q61R,GoF,Oncogene
+21,MM485,ACH-001973,CVCL_2610,Skin,SMARCB1,Het,Missense,p.W349L,LoF,Suppressor
+22,MM485,ACH-001973,CVCL_2610,Skin,TP53,Hom,Stopgain,p.R196*,LoF,Suppressor
+23,MM415,ACH-001569,CVCL_2608,Skin,KMT2D,Het,Missense,p.T680P,,Suppressor
+24,MM415,ACH-001569,CVCL_2608,Skin,MTOR,Het,Missense,p.L2185F,,Oncogene
+25,MM415,ACH-001569,CVCL_2608,Skin,NF1,Het,Stopgain,p.R1276*,LoF,Suppressor
+26,MM415,ACH-001569,CVCL_2608,Skin,NRAS,Het,Missense,p.Q61L,GoF,Oncogene
+27,MM415,ACH-001569,CVCL_2608,Skin,SMARCB1,Het,Missense,p.T214M,LoF,Suppressor
+28,MM415,ACH-001569,CVCL_2608,Skin,TP53,Hom,Missense,p.A347V,,Suppressor
+29,MCF-7,ACH-000019,CVCL_0031,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+30,MCF-7,ACH-000019,CVCL_0031,Breast,GNAS,,Gain,GAIN,GoF,Oncogene
+31,MCF-7,ACH-000019,CVCL_0031,Breast,NRAS,,Gain,GAIN,GoF,Oncogene
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+33,MCF-7,ACH-000019,CVCL_0031,Breast,SMAD3,Het,Splice_site,p.V90F,LoF,Suppressor
+34,MCF-7,ACH-000019,CVCL_0031,Breast,WNK2,Het,Missense,p.L312Q,,Suppressor
+35,SK-MEL-30,ACH-000810,CVCL_0039,Skin,APC,Het,Missense,p.G1339R,,Suppressor
+36,SK-MEL-30,ACH-000810,CVCL_0039,Skin,APC,Het,Stopgain,p.Q1406*,LoF,Suppressor
+37,SK-MEL-30,ACH-000810,CVCL_0039,Skin,BRAF,Het,Missense,p.E275K,,Oncogene
+38,SK-MEL-30,ACH-000810,CVCL_0039,Skin,CDKN2A,Hom,Missense,p.P63L,LoF,Suppressor
+39,SK-MEL-30,ACH-000810,CVCL_0039,Skin,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+40,SK-MEL-30,ACH-000810,CVCL_0039,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene
+41,SK-MEL-30,ACH-000810,CVCL_0039,Skin,TP53,Het,Missense,p.R273H,LoF,Suppressor
+42,SK-MEL-30,ACH-000810,CVCL_0039,Skin,TP53,Het,Frameshift,p.T284fs,LoF,Suppressor
+43,SW620,ACH-000651,CVCL_0547,Bowel,APC,Hom,Stopgain,p.Q1338*,LoF,Suppressor
+44,SW620,ACH-000651,CVCL_0547,Bowel,EGFR,Het,Missense,p.C186S,,Oncogene
+45,SW620,ACH-000651,CVCL_0547,Bowel,EP300,Het,Missense,p.P1440L,LoF,Suppressor
+46,SW620,ACH-000651,CVCL_0547,Bowel,KRAS,,Gain,GAIN,GoF,Oncogene
+47,SW620,ACH-000651,CVCL_0547,Bowel,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
+48,SW620,ACH-000651,CVCL_0547,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
+49,SW620,ACH-000651,CVCL_0547,Bowel,TP53,Hom,Missense,p.P309S,LoF,Suppressor
+50,SW620,ACH-000651,CVCL_0547,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
+51,COLO 205,ACH-001039,CVCL_0218,Bowel,APC,Hom,Frameshift,p.T1556fs,LoF,Suppressor
+52,COLO 205,ACH-001039,CVCL_0218,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+53,COLO 205,ACH-001039,CVCL_0218,Bowel,CTNNB1,Hom,Missense,p.N287S,,Oncogene
+54,COLO 205,ACH-001039,CVCL_0218,Bowel,GNAS,Het,Missense,p.S95I,,Oncogene
+55,COLO 205,ACH-001039,CVCL_0218,Bowel,MTOR,Het,Missense,p.P1193L,,Oncogene
+56,COLO 205,ACH-001039,CVCL_0218,Bowel,PMS2,Het,Missense,p.E504Q,,Suppressor
+57,COLO 205,ACH-001039,CVCL_0218,Bowel,TP53,Hom,Frameshift,p.Y103fs,LoF,Suppressor
+58,COLO 205,ACH-001039,CVCL_0218,Bowel,TP53,Hom,Frameshift,p.Y107fs,LoF,Suppressor
+59,HCC-2998,ACH-001081,CVCL_1266,Bowel,ACVR2A,Het,Stopgain,p.E112*,LoF,Suppressor
+60,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.I2167S,LoF,Suppressor
+61,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Stopgain,p.L665*,LoF,Suppressor
+62,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.N2720K,,Suppressor
+63,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
+64,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.R168I,LoF,Suppressor
+65,HCC-2998,ACH-001081,CVCL_1266,Bowel,APC,Het,Missense,p.S1864Y,LoF,Suppressor
+66,HCC-2998,ACH-001081,CVCL_1266,Bowel,ARID1A,Het,Stopgain,p.R1772*,LoF,Suppressor
+67,HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.E1133K,,Suppressor
+68,HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Stopgain,p.E277*,LoF,Suppressor
+69,HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.L1439I,,Suppressor
+70,HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Stopgain,p.R250*,LoF,Suppressor
+71,HCC-2998,ACH-001081,CVCL_1266,Bowel,ATM,Het,Missense,p.R337C,LoF,Suppressor
+72,HCC-2998,ACH-001081,CVCL_1266,Bowel,B2M,Het,Stopgain,p.E56*,LoF,Suppressor
+73,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.D1177N,,Suppressor
+74,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.E3342K,,Suppressor
+75,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.K817N,,Suppressor
+76,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.K981N,,Suppressor
+77,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.L2136V,,Suppressor
+78,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.P288S,,Suppressor
+79,HCC-2998,ACH-001081,CVCL_1266,Bowel,BRCA2,Het,Missense,p.R2896C,,Suppressor
+80,HCC-2998,ACH-001081,CVCL_1266,Bowel,CDKN2A,Het,Missense,p.A36G,LoF,Suppressor
+81,HCC-2998,ACH-001081,CVCL_1266,Bowel,EP300,Het,Stopgain,p.E465*,LoF,Suppressor
+82,HCC-2998,ACH-001081,CVCL_1266,Bowel,EP300,Het,Missense,p.L1584R,LoF,Suppressor
+83,HCC-2998,ACH-001081,CVCL_1266,Bowel,FBXW7,Het,Missense,p.R609W,LoF,Suppressor
+84,HCC-2998,ACH-001081,CVCL_1266,Bowel,JAK1,Het,Missense,p.R755Q,,Oncogene
+85,HCC-2998,ACH-001081,CVCL_1266,Bowel,KMT2D,Het,Missense,p.T2131P,,Suppressor
+86,HCC-2998,ACH-001081,CVCL_1266,Bowel,KRAS,Het,Missense,p.A146T,GoF,Oncogene
+87,HCC-2998,ACH-001081,CVCL_1266,Bowel,MSH6,Het,Missense,p.K885N,,Suppressor
+88,HCC-2998,ACH-001081,CVCL_1266,Bowel,MTOR,Het,Missense,p.I2500M,GoF,Oncogene
+89,HCC-2998,ACH-001081,CVCL_1266,Bowel,MYCL,Het,Missense,p.R357I,,Oncogene
+90,HCC-2998,ACH-001081,CVCL_1266,Bowel,NF1,Het,Missense,p.K609N,,Suppressor
+91,HCC-2998,ACH-001081,CVCL_1266,Bowel,NF2,Het,Missense,p.K99T,LoF,Suppressor
+92,HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3CB,Het,Missense,p.R149Q,,Oncogene
+93,HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3CB,Het,Missense,p.R562Q,,Oncogene
+94,HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3R1,Het,Stopgain,p.R98*,LoF,Suppressor
+95,HCC-2998,ACH-001081,CVCL_1266,Bowel,PIK3R1,Het,Splice_site,,LoF,Suppressor
+96,HCC-2998,ACH-001081,CVCL_1266,Bowel,PMS2,Het,Missense,p.A854T,,Suppressor
+97,HCC-2998,ACH-001081,CVCL_1266,Bowel,PMS2,Het,Missense,p.D286E,,Suppressor
+98,HCC-2998,ACH-001081,CVCL_1266,Bowel,POLE,Het,Missense,p.P286R,LoF,Suppressor
+99,HCC-2998,ACH-001081,CVCL_1266,Bowel,PRDM2,Het,Missense,p.L595V,,Suppressor
+100,HCC-2998,ACH-001081,CVCL_1266,Bowel,PRDM2,Het,Missense,p.S470Y,,Suppressor
+101,HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.F341V,LoF,Suppressor
+102,HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.R130Q,LoF,Suppressor
+103,HCC-2998,ACH-001081,CVCL_1266,Bowel,PTEN,Het,Missense,p.Y46C,LoF,Suppressor
+104,HCC-2998,ACH-001081,CVCL_1266,Bowel,PTPN11,Het,Missense,p.I54T,,Oncogene
+105,HCC-2998,ACH-001081,CVCL_1266,Bowel,RAF1,Het,Missense,p.S257L,GoF,Oncogene
+106,HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Stopgain,p.E137*,LoF,Suppressor
+107,HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Missense,p.F473C,LoF,Suppressor
+108,HCC-2998,ACH-001081,CVCL_1266,Bowel,RB1,Het,Missense,p.K80N,,Suppressor
+109,HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD2,Het,Missense,p.R321Q,LoF,Suppressor
+110,HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD2,Het,Missense,p.S276L,LoF,Suppressor
+111,HCC-2998,ACH-001081,CVCL_1266,Bowel,SMAD3,Het,Missense,p.S222L,LoF,Suppressor
+112,HCC-2998,ACH-001081,CVCL_1266,Bowel,SOS1,Het,Missense,p.I736R,,Oncogene
+113,HCC-2998,ACH-001081,CVCL_1266,Bowel,TP53,Het,Stopgain,p.R213*,LoF,Suppressor
+114,HCC-2998,ACH-001081,CVCL_1266,Bowel,XPO1,Het,Missense,p.E571K,GoF,Oncogene
+115,HCC-2998,ACH-001081,CVCL_1266,Bowel,XPO1,Het,Missense,p.R712I,,Oncogene
+116,NCI-H1385,ACH-000737,CVCL_1466,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+117,SW1463,ACH-000470,CVCL_1718,Bowel,APC,Hom,Frameshift,p.V452fs,LoF,Suppressor
+118,SW1463,ACH-000470,CVCL_1718,Bowel,ARID1A,Het,Missense,p.L2042V,,Suppressor
+119,SW1463,ACH-000470,CVCL_1718,Bowel,FBXW7,Het,Missense,p.R399Q,LoF,Suppressor
+120,SW1463,ACH-000470,CVCL_1718,Bowel,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
+121,SW1463,ACH-000470,CVCL_1718,Bowel,MTOR,Het,Missense,p.A1099G,,Oncogene
+122,SW1463,ACH-000470,CVCL_1718,Bowel,RNF43,Het,Missense,p.R223P,,Suppressor
+123,SW1463,ACH-000470,CVCL_1718,Bowel,SMAD4,Hom,Missense,p.R265G,LoF,Suppressor
+124,SW1463,ACH-000470,CVCL_1718,Bowel,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
+125,SW837,ACH-000421,CVCL_1729,Bowel,ACVR2A,Hom,Splice_site,,LoF,Suppressor
+126,SW837,ACH-000421,CVCL_1729,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
+127,SW837,ACH-000421,CVCL_1729,Bowel,APC,Het,Stopgain,p.R213*,LoF,Suppressor
+128,SW837,ACH-000421,CVCL_1729,Bowel,ATM,Het,Missense,p.H448R,,Suppressor
+129,SW837,ACH-000421,CVCL_1729,Bowel,EGFR,Het,Missense,p.C186S,,Oncogene
+130,SW837,ACH-000421,CVCL_1729,Bowel,EGFR,Het,Missense,p.R264G,,Oncogene
+131,SW837,ACH-000421,CVCL_1729,Bowel,FBXW7,Hom,Frameshift,p.L323fs,LoF,Suppressor
+132,SW837,ACH-000421,CVCL_1729,Bowel,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+133,SW837,ACH-000421,CVCL_1729,Bowel,TP53,Hom,Missense,p.R248W,LoF,Suppressor
+134,LU65,ACH-000438,CVCL_1392,Lung,CDKN2A,Het,Missense,p.D23P,,Suppressor
+135,LU65,ACH-000438,CVCL_1392,Lung,CDKN2A,Hom,Missense,p.H15R,LoF,Suppressor
+136,LU65,ACH-000438,CVCL_1392,Lung,EGFR,Het,Missense,p.L858R,,Oncogene
+137,LU65,ACH-000438,CVCL_1392,Lung,KRAS,,Gain,GAIN,GoF,Oncogene
+138,LU65,ACH-000438,CVCL_1392,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+139,LU65,ACH-000438,CVCL_1392,Lung,RB1,Hom,Stopgain,p.S82*,LoF,Suppressor
+140,LU65,ACH-000438,CVCL_1392,Lung,STK11,Hom,Splice_site,,LoF,Suppressor
+141,LU65,ACH-000438,CVCL_1392,Lung,TP53,Het,Missense,p.E11Q,,Suppressor
+142,LU65,ACH-000438,CVCL_1392,Lung,TP53,Hom,Splice_site,p.T125T,LoF,Suppressor
+143,LU65,ACH-000438,CVCL_1392,Lung,WNK2,Hom,Missense,p.V1821M,,Suppressor
+144,LU99,ACH-000444,CVCL_3015,Lung,BRCA2,Het,Missense,p.M784V,,Suppressor
+145,LU99,ACH-000444,CVCL_3015,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+146,LU99,ACH-000444,CVCL_3015,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+147,LU99,ACH-000444,CVCL_3015,Lung,EP300,Hom,Frameshift,p.I967fs,LoF,Suppressor
+148,LU99,ACH-000444,CVCL_3015,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+149,LU99,ACH-000444,CVCL_3015,Lung,NF2,Hom,Splice_site,,LoF,Suppressor
+150,LU99,ACH-000444,CVCL_3015,Lung,PIK3CA,Het,Missense,p.T1025A,GoF,Oncogene
+151,LU99,ACH-000444,CVCL_3015,Lung,POLE,Het,Missense,p.D535Y,LoF,Suppressor
+152,LU99,ACH-000444,CVCL_3015,Lung,ZFHX3,Hom,Missense,p.E1900A,,Suppressor
+153,HT-29,ACH-000552,CVCL_0320,Bowel,APC,Het,Stopgain,p.E853*,LoF,Suppressor
+154,HT-29,ACH-000552,CVCL_0320,Bowel,APC,Het,Frameshift,p.T1556fs,LoF,Suppressor
+155,HT-29,ACH-000552,CVCL_0320,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+156,HT-29,ACH-000552,CVCL_0320,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
+157,HT-29,ACH-000552,CVCL_0320,Bowel,PIK3CA,Het,Missense,p.P449T,,Oncogene
+158,HT-29,ACH-000552,CVCL_0320,Bowel,SMAD4,Hom,Stopgain,p.Q311*,LoF,Suppressor
+159,HT-29,ACH-000552,CVCL_0320,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
+160,HT-29,ACH-000552,CVCL_0320,Bowel,ZFHX3,Het,Missense,p.I1217M,,Suppressor
+161,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,APC,Het,Missense,p.D1810E,,Suppressor
+162,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,ATM,Het,Missense,p.R924W,,Suppressor
+163,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,CCND1,,Gain,GAIN,GoF,Oncogene
+164,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,ERBB2,,Gain,GAIN,GoF,Oncogene
+165,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,KMT2D,Het,Missense,p.Q3904H,,Suppressor
+166,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+167,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,SMARCA4,Het,Missense,p.V1207I,,Suppressor
+168,KYSE-410,ACH-000809,CVCL_1352,Esophagus/Stomach,TP53,Hom,Missense,p.R337C,LoF,Suppressor
+169,NCI-H358,ACH-000860,CVCL_1559,Lung,ERBB3,Het,Missense,p.R421K,,Oncogene
+170,NCI-H358,ACH-000860,CVCL_1559,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+171,NCI-H358,ACH-000860,CVCL_1559,Lung,POLE,Het,Missense,p.V1270F,,Suppressor
+172,NCI-H358,ACH-000860,CVCL_1559,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
+173,NCI-H358,ACH-000860,CVCL_1559,Lung,ZFHX3,Het,Missense,p.R1402C,LoF,Suppressor
+174,NCI-H1373,ACH-000845,CVCL_1465,Lung,ATM,Het,Stopgain,p.E2943*,LoF,Suppressor
+175,NCI-H1373,ACH-000845,CVCL_1465,Lung,CDKN2A,Hom,Stopgain,p.C21*,LoF,Suppressor
+176,NCI-H1373,ACH-000845,CVCL_1465,Lung,CHEK2,Het,Missense,p.D207Y,,Suppressor
+177,NCI-H1373,ACH-000845,CVCL_1465,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+178,NCI-H1373,ACH-000845,CVCL_1465,Lung,NF1,Het,Missense,p.I1806M,LoF,Suppressor
+179,NCI-H1373,ACH-000845,CVCL_1465,Lung,TP53,Hom,Stopgain,p.E339*,LoF,Suppressor
+180,NCI-H1373,ACH-000845,CVCL_1465,Lung,TP53,Hom,Missense,p.P47L,,Suppressor
+181,NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.G431R,,Suppressor
+182,NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.P1097S,,Suppressor
+183,NCI-H1373,ACH-000845,CVCL_1465,Lung,WNK2,Het,Missense,p.S1520I,,Suppressor
+184,Calu-1,ACH-000511,CVCL_0608,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+185,Calu-1,ACH-000511,CVCL_0608,Lung,SETD1B,Het,Missense,p.Q1589P,,Suppressor
+186,Calu-1,ACH-000511,CVCL_0608,Lung,TERT,,Promoter,1-124C>T,GoF,Oncogene
+187,Calu-1,ACH-000511,CVCL_0608,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
+188,DLD-1,ACH-001061,CVCL_0248,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+189,DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Hom,Frameshift,p.I1417fs,LoF,Suppressor
+190,DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Missense,p.K993N,,Suppressor
+191,DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Stopgain,p.R2166*,LoF,Suppressor
+192,DLD-1,ACH-001061,CVCL_0248,Bowel,APC,Het,Missense,p.R727M,LoF,Suppressor
+193,DLD-1,ACH-001061,CVCL_0248,Bowel,B2M,Het,Stopgain,p.Y30*,LoF,Suppressor
+194,DLD-1,ACH-001061,CVCL_0248,Bowel,B2M,Het,Splice_site,,LoF,Suppressor
+195,DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Missense,p.L1053S,,Suppressor
+196,DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
+197,DLD-1,ACH-001061,CVCL_0248,Bowel,BRCA2,Het,Missense,p.R2784Q,LoF,Suppressor
+198,DLD-1,ACH-001061,CVCL_0248,Bowel,CHEK2,Het,Missense,p.A247D,LoF,Suppressor
+199,DLD-1,ACH-001061,CVCL_0248,Bowel,CHEK2,Het,Missense,p.R145W,LoF,Suppressor
+200,DLD-1,ACH-001061,CVCL_0248,Bowel,EP300,Het,Stopgain,p.E1014*,LoF,Suppressor
+201,DLD-1,ACH-001061,CVCL_0248,Bowel,EP300,Het,Missense,p.R838C,,Suppressor
+202,DLD-1,ACH-001061,CVCL_0248,Bowel,ERBB3,Het,Missense,p.R667H,,Oncogene
+203,DLD-1,ACH-001061,CVCL_0248,Bowel,FBXW7,Het,Missense,p.P29S,,Suppressor
+204,DLD-1,ACH-001061,CVCL_0248,Bowel,GNAS,Het,Missense,p.K338N,,Oncogene
+205,DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.E1517D,,Suppressor
+206,DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.E1667D,,Suppressor
+207,DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.F5284L,,Suppressor
+208,DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.L2304M,,Suppressor
+209,DLD-1,ACH-001061,CVCL_0248,Bowel,KMT2D,Het,Missense,p.P1931H,,Suppressor
+210,DLD-1,ACH-001061,CVCL_0248,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
+211,DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Frameshift,p.D1171fs,LoF,Suppressor
+212,DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Frameshift,p.L290fs,LoF,Suppressor
+213,DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Missense,p.R1172del,,Suppressor
+214,DLD-1,ACH-001061,CVCL_0248,Bowel,MSH6,Het,Missense,p.Y469F,,Suppressor
+215,DLD-1,ACH-001061,CVCL_0248,Bowel,NF1,Het,Missense,p.A2596V,,Suppressor
+216,DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3CA,Het,Missense,p.D549N,GoF,Oncogene
+217,DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
+218,DLD-1,ACH-001061,CVCL_0248,Bowel,PIK3R1,Het,Missense,p.P312L,,Suppressor
+219,DLD-1,ACH-001061,CVCL_0248,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+220,DLD-1,ACH-001061,CVCL_0248,Bowel,RNF43,Het,Missense,p.L214M,,Suppressor
+221,DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Missense,p.D159N,,Suppressor
+222,DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
+223,DLD-1,ACH-001061,CVCL_0248,Bowel,SETD1B,Het,Missense,p.Q780H,LoF,Suppressor
+224,DLD-1,ACH-001061,CVCL_0248,Bowel,SMARCA4,Het,Missense,p.R885C,LoF,Suppressor
+225,DLD-1,ACH-001061,CVCL_0248,Bowel,TGFBR2,Het,Frameshift,p.K128fs,LoF,Suppressor
+226,DLD-1,ACH-001061,CVCL_0248,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
+227,DLD-1,ACH-001061,CVCL_0248,Bowel,TP53,Het,Missense,p.S241F,LoF,Suppressor
+228,DLD-1,ACH-001061,CVCL_0248,Bowel,TP53,Het,Splice_site,,LoF,Suppressor
+229,DLD-1,ACH-001061,CVCL_0248,Bowel,ZFHX3,Het,Missense,p.P1707H,,Suppressor
+230,DLD-1,ACH-001061,CVCL_0248,Bowel,ZFHX3,Het,Missense,p.P3069T,LoF,Suppressor
+231,LS123,ACH-000501,CVCL_1383,Bowel,ACVR2A,Het,Missense,p.R400H,LoF,Suppressor
+232,LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Missense,p.M431I,,Suppressor
+233,LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Stopgain,p.Q625*,LoF,Suppressor
+234,LS123,ACH-000501,CVCL_1383,Bowel,APC,Het,Stopgain,p.R1450*,LoF,Suppressor
+235,LS123,ACH-000501,CVCL_1383,Bowel,KRAS,Het,Missense,p.G12S,GoF,Oncogene
+236,LS123,ACH-000501,CVCL_1383,Bowel,MTOR,Het,Missense,p.A1099G,,Oncogene
+237,LS123,ACH-000501,CVCL_1383,Bowel,SMAD4,Hom,Stopgain,p.E234*,LoF,Suppressor
+238,LS123,ACH-000501,CVCL_1383,Bowel,TP53,Hom,Missense,p.R175H,LoF,Suppressor
+239,Caco-2,ACH-000003,CVCL_0025,Bowel,APC,Hom,Stopgain,p.Q1367*,LoF,Suppressor
+240,Caco-2,ACH-000003,CVCL_0025,Bowel,CHEK2,,Deletion,DEL,LoF,Suppressor
+241,Caco-2,ACH-000003,CVCL_0025,Bowel,CTNNB1,Het,Missense,p.G245A,,Oncogene
+242,Caco-2,ACH-000003,CVCL_0025,Bowel,EP300,,Deletion,DEL,LoF,Suppressor
+243,Caco-2,ACH-000003,CVCL_0025,Bowel,NF2,,Deletion,DEL,LoF,Suppressor
+244,Caco-2,ACH-000003,CVCL_0025,Bowel,SMAD4,Hom,Missense,p.D351H,,Suppressor
+245,Caco-2,ACH-000003,CVCL_0025,Bowel,SMARCB1,,Deletion,DEL,LoF,Suppressor
+246,Caco-2,ACH-000003,CVCL_0025,Bowel,TP53,Hom,Stopgain,p.E204*,LoF,Suppressor
+247,HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Frameshift,p.I1417fs,LoF,Suppressor
+248,HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Missense,p.K993N,,Suppressor
+249,HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Stopgain,p.R2166*,LoF,Suppressor
+250,HCT-8,ACH-001084,CVCL_2478,Bowel,APC,,Missense,p.R727M,LoF,Suppressor
+251,HCT-8,ACH-001084,CVCL_2478,Bowel,CTNNB1,,Missense,p.V79I,,Oncogene
+252,HCT-8,ACH-001084,CVCL_2478,Bowel,KRAS,,Missense,p.G13D,GoF,Oncogene
+253,HCT-8,ACH-001084,CVCL_2478,Bowel,PIK3CA,,Missense,p.D549N,GoF,Oncogene
+254,HCT-8,ACH-001084,CVCL_2478,Bowel,PIK3CA,,Missense,p.E545K,GoF,Oncogene
+255,HCT-8,ACH-001084,CVCL_2478,Bowel,SMAD2,,Frameshift,p.P164fs,LoF,Suppressor
+256,HCT-8,ACH-001084,CVCL_2478,Bowel,SMAD3,,Missense,p.V244I,,Suppressor
+257,SK-CO-1,ACH-000400,CVCL_0626,Bowel,APC,Het,Frameshift,p.F1089fs,LoF,Suppressor
+258,SK-CO-1,ACH-000400,CVCL_0626,Bowel,APC,Het,Frameshift,p.P1443fs,LoF,Suppressor
+259,SK-CO-1,ACH-000400,CVCL_0626,Bowel,EP300,Het,Missense,p.P842S,,Suppressor
+260,SK-CO-1,ACH-000400,CVCL_0626,Bowel,GNAS,Het,Missense,p.R201C,,Oncogene
+261,SK-CO-1,ACH-000400,CVCL_0626,Bowel,KRAS,Het,Missense,p.G12V,GoF,Oncogene
+262,SK-CO-1,ACH-000400,CVCL_0626,Bowel,SETD1B,Het,Missense,p.Q1589P,,Suppressor
+263,SW480,ACH-000842,CVCL_0546,Bowel,APC,Hom,Stopgain,p.Q1338*,LoF,Suppressor
+264,SW480,ACH-000842,CVCL_0546,Bowel,ATM,Het,Missense,p.R2461P,LoF,Suppressor
+265,SW480,ACH-000842,CVCL_0546,Bowel,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
+266,SW480,ACH-000842,CVCL_0546,Bowel,MYC,,Gain,GAIN,GoF,Oncogene
+267,SW480,ACH-000842,CVCL_0546,Bowel,TP53,Hom,Missense,p.P309S,LoF,Suppressor
+268,SW480,ACH-000842,CVCL_0546,Bowel,TP53,Hom,Missense,p.R273H,LoF,Suppressor
+269,SW 1573,ACH-000677,CVCL_1720,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+270,SW 1573,ACH-000677,CVCL_1720,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+271,SW 1573,ACH-000677,CVCL_1720,Lung,CTNNB1,Het,Missense,p.S33F,GoF,Oncogene
+272,SW 1573,ACH-000677,CVCL_1720,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
+273,SW 1573,ACH-000677,CVCL_1720,Lung,PIK3CA,Het,Missense,p.K111E,GoF,Oncogene
+274,SW 1573,ACH-000677,CVCL_1720,Lung,PRDM2,Hom,Missense,p.L824Q,,Suppressor
+275,SW 1573,ACH-000677,CVCL_1720,Lung,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
+276,SW 1573,ACH-000677,CVCL_1720,Lung,SMARCB1,Hom,Splice_site,,LoF,Suppressor
+277,HCC1143,ACH-000374,CVCL_1245,Breast,AKT1,,Gain,GAIN,GoF,Oncogene
+278,HCC1143,ACH-000374,CVCL_1245,Breast,CCND1,,Gain,GAIN,GoF,Oncogene
+279,HCC1143,ACH-000374,CVCL_1245,Breast,FGFR2,Het,Missense,p.R203C,,Oncogene
+280,HCC1143,ACH-000374,CVCL_1245,Breast,SMARCA4,Het,Missense,p.R1323H,LoF,Suppressor
+281,HCC1143,ACH-000374,CVCL_1245,Breast,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
+282,HS-578T,ACH-000148,CVCL_0332,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+283,HS-578T,ACH-000148,CVCL_0332,Breast,HNF1A,Het,Missense,p.K273E,LoF,Suppressor
+284,HS-578T,ACH-000148,CVCL_0332,Breast,HRAS,Het,Missense,p.G12D,GoF,Oncogene
+285,HS-578T,ACH-000148,CVCL_0332,Breast,NF1,Het,Missense,p.G2724R,,Suppressor
+286,HS-578T,ACH-000148,CVCL_0332,Breast,PIK3R1,Hom,Missense,p.89_90insN,,Suppressor
+287,HS-578T,ACH-000148,CVCL_0332,Breast,TP53,Hom,Missense,p.V157F,LoF,Suppressor
+288,SW1116,ACH-000489,CVCL_0544,Bowel,APC,Het,Frameshift,p.Q1429fs,LoF,Suppressor
+289,SW1116,ACH-000489,CVCL_0544,Bowel,APC,Het,Stopgain,p.Q264*,LoF,Suppressor
+290,SW1116,ACH-000489,CVCL_0544,Bowel,FBXW7,Het,Missense,p.H380Y,LoF,Suppressor
+291,SW1116,ACH-000489,CVCL_0544,Bowel,KRAS,Het,Missense,p.G12A,GoF,Oncogene
+292,SW1116,ACH-000489,CVCL_0544,Bowel,TP53,Hom,Missense,p.A159D,LoF,Suppressor
+293,SW1116,ACH-000489,CVCL_0544,Bowel,WNK2,Het,Missense,p.A1048G,,Suppressor
+294,SW1116,ACH-000489,CVCL_0544,Bowel,ZFHX3,Het,Missense,p.G918R,,Suppressor
+295,LoVo,ACH-000950,CVCL_0399,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+296,LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Frameshift,p.M1431fs,LoF,Suppressor
+297,LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Stopgain,p.R1114*,LoF,Suppressor
+298,LoVo,ACH-000950,CVCL_0399,Bowel,APC,Het,Missense,p.R2816Q,,Suppressor
+299,LoVo,ACH-000950,CVCL_0399,Bowel,ARID1A,Het,Frameshift,p.F1924fs,LoF,Suppressor
+300,LoVo,ACH-000950,CVCL_0399,Bowel,B2M,Hom,Frameshift,p.L15fs,LoF,Suppressor
+301,LoVo,ACH-000950,CVCL_0399,Bowel,CHEK2,Het,Frameshift,p.T389fs,LoF,Suppressor
+302,LoVo,ACH-000950,CVCL_0399,Bowel,FBXW7,Het,Missense,p.R425C,LoF,Suppressor
+303,LoVo,ACH-000950,CVCL_0399,Bowel,FGFR3,Het,Missense,p.I533V,,Oncogene
+304,LoVo,ACH-000950,CVCL_0399,Bowel,HNF1A,Het,Missense,p.V446M,LoF,Suppressor
+305,LoVo,ACH-000950,CVCL_0399,Bowel,KMT2D,Het,Frameshift,p.H77fs,LoF,Suppressor
+306,LoVo,ACH-000950,CVCL_0399,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
+307,LoVo,ACH-000950,CVCL_0399,Bowel,NF1,Het,Missense,p.R1674Q,,Suppressor
+308,LoVo,ACH-000950,CVCL_0399,Bowel,PIK3CB,Het,Missense,p.E1051K,,Oncogene
+309,LoVo,ACH-000950,CVCL_0399,Bowel,PRDM2,Het,Missense,p.S1618G,,Suppressor
+310,LoVo,ACH-000950,CVCL_0399,Bowel,PRDM2,Het,Frameshift,p.V1490fs,LoF,Suppressor
+311,LoVo,ACH-000950,CVCL_0399,Bowel,RAF1,Het,Missense,p.V98A,,Oncogene
+312,LoVo,ACH-000950,CVCL_0399,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
+313,LoVo,ACH-000950,CVCL_0399,Bowel,SETD1B,Het,Missense,p.V1447I,,Suppressor
+314,LoVo,ACH-000950,CVCL_0399,Bowel,SMAD2,Het,Missense,p.A292V,LoF,Suppressor
+315,LoVo,ACH-000950,CVCL_0399,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
+316,LoVo,ACH-000950,CVCL_0399,Bowel,WNK2,Het,Missense,p.R2073C,,Suppressor
+317,LoVo,ACH-000950,CVCL_0399,Bowel,WNK2,Het,Missense,p.V1544A,,Suppressor
+318,SW948,ACH-000680,CVCL_0632,Bowel,APC,Het,Stopgain,p.Q1429*,LoF,Suppressor
+319,SW948,ACH-000680,CVCL_0632,Bowel,APC,Het,Stopgain,p.R1114*,LoF,Suppressor
+320,SW948,ACH-000680,CVCL_0632,Bowel,ARID1A,Het,Missense,p.G701A,,Suppressor
+321,SW948,ACH-000680,CVCL_0632,Bowel,ATM,Het,Stopgain,p.Q2210*,LoF,Suppressor
+322,SW948,ACH-000680,CVCL_0632,Bowel,EP300,Het,Splice_site,,LoF,Suppressor
+323,SW948,ACH-000680,CVCL_0632,Bowel,KMT2D,Het,Missense,p.N2030H,,Suppressor
+324,SW948,ACH-000680,CVCL_0632,Bowel,KMT2D,Het,Missense,p.R5120C,LoF,Suppressor
+325,SW948,ACH-000680,CVCL_0632,Bowel,KRAS,Het,Missense,p.Q61L,GoF,Oncogene
+326,SW948,ACH-000680,CVCL_0632,Bowel,PIK3CA,Hom,Missense,p.E542K,GoF,Oncogene
+327,SW948,ACH-000680,CVCL_0632,Bowel,SMAD4,Hom,Missense,p.D441Y,LoF,Suppressor
+328,SW948,ACH-000680,CVCL_0632,Bowel,TP53,Hom,Frameshift,p.T118fs,LoF,Suppressor
+329,LS 174T,,CVCL_1384,Bowel,CTNNB1,Hom,Missense,p.S45F,GoF,Oncogene
+330,LS 174T,,CVCL_1384,Bowel,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+331,LS 174T,,CVCL_1384,Bowel,PIK3CA,,Missense,p.H1047R,GoF,Oncogene
+332,SW1417,ACH-000236,CVCL_1717,Bowel,APC,Hom,Stopgain,p.R1450*,LoF,Suppressor
+333,SW1417,ACH-000236,CVCL_1717,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+334,SW1417,ACH-000236,CVCL_1717,Bowel,PIK3R1,Hom,Deletion,DEL,LoF,Suppressor
+335,SW1417,ACH-000236,CVCL_1717,Bowel,TP53,Hom,Frameshift,p.C238fs,LoF,Suppressor
+336,RKO,ACH-000943,CVCL_0504,Bowel,ACVR2A,Het,Frameshift,p.K437fs,LoF,Suppressor
+337,RKO,ACH-000943,CVCL_0504,Bowel,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
+338,RKO,ACH-000943,CVCL_0504,Bowel,ARID1A,Het,Frameshift,p.P1115fs,LoF,Suppressor
+339,RKO,ACH-000943,CVCL_0504,Bowel,B2M,Het,Stopgain,p.R117*,LoF,Suppressor
+340,RKO,ACH-000943,CVCL_0504,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+341,RKO,ACH-000943,CVCL_0504,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
+342,RKO,ACH-000943,CVCL_0504,Bowel,EP300,Het,Frameshift,p.K292fs,LoF,Suppressor
+343,RKO,ACH-000943,CVCL_0504,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
+344,RKO,ACH-000943,CVCL_0504,Bowel,HNF1A,Het,Frameshift,p.P379fs,LoF,Suppressor
+345,RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Frameshift,p.G1960fs,LoF,Suppressor
+346,RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Stopgain,p.G3465*,LoF,Suppressor
+347,RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Missense,p.L1600P,LoF,Suppressor
+348,RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Missense,p.L5056P,LoF,Suppressor
+349,RKO,ACH-000943,CVCL_0504,Bowel,KMT2D,Het,Frameshift,p.P2550fs,LoF,Suppressor
+350,RKO,ACH-000943,CVCL_0504,Bowel,MSH6,Het,Frameshift,p.Y1066fs,LoF,Suppressor
+351,RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Frameshift,p.N2320fs,LoF,Suppressor
+352,RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Missense,p.V2184A,LoF,Suppressor
+353,RKO,ACH-000943,CVCL_0504,Bowel,NF1,Het,Frameshift,p.Y628fs,LoF,Suppressor
+354,RKO,ACH-000943,CVCL_0504,Bowel,NF2,Het,Frameshift,p.P275fs,LoF,Suppressor
+355,RKO,ACH-000943,CVCL_0504,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
+356,RKO,ACH-000943,CVCL_0504,Bowel,POLE,Het,Missense,p.K995E,,Suppressor
+357,RKO,ACH-000943,CVCL_0504,Bowel,PRDM2,Het,Missense,p.S876G,,Suppressor
+358,RKO,ACH-000943,CVCL_0504,Bowel,RNF43,Hom,Frameshift,p.G659fs,LoF,Suppressor
+359,RKO,ACH-000943,CVCL_0504,Bowel,RNF43,Het,Missense,p.H549N,,Suppressor
+360,RKO,ACH-000943,CVCL_0504,Bowel,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
+361,RKO,ACH-000943,CVCL_0504,Bowel,SETD1B,Het,Missense,p.T1700A,LoF,Suppressor
+362,RKO,ACH-000943,CVCL_0504,Bowel,SMAD3,Het,Missense,p.A13T,,Suppressor
+363,RKO,ACH-000943,CVCL_0504,Bowel,TGFBR2,Het,Frameshift,p.K128fs,LoF,Suppressor
+364,RKO,ACH-000943,CVCL_0504,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
+365,RKO,ACH-000943,CVCL_0504,Bowel,ZFHX3,Het,Frameshift,p.F1596fs,LoF,Suppressor
+366,RKO,ACH-000943,CVCL_0504,Bowel,ZFHX3,Het,Missense,p.S112N,,Suppressor
+367,T84,ACH-000381,CVCL_0555,Bowel,APC,Hom,Frameshift,p.L1488fs,LoF,Suppressor
+368,T84,ACH-000381,CVCL_0555,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
+369,T84,ACH-000381,CVCL_0555,Bowel,PIK3CA,Het,Missense,p.E542K,GoF,Oncogene
+370,T84,ACH-000381,CVCL_0555,Bowel,SMAD4,Hom,Missense,p.K244N,LoF,Suppressor
+371,T84,ACH-000381,CVCL_0555,Bowel,TP53,Hom,Splice_site,,LoF,Suppressor
+372,T84,ACH-000381,CVCL_0555,Bowel,ZFHX3,Het,Missense,p.A3398P,,Suppressor
+373,SHP-77,ACH-000790,CVCL_1693,Lung,ABL1,Het,Missense,p.V1128E,,Oncogene
+374,SHP-77,ACH-000790,CVCL_1693,Lung,ACVR2A,Hom,Missense,p.L147R,LoF,Suppressor
+375,SHP-77,ACH-000790,CVCL_1693,Lung,ARID1A,Het,Missense,p.P253S,,Suppressor
+376,SHP-77,ACH-000790,CVCL_1693,Lung,EGFR,Het,Missense,p.Q656R,,Oncogene
+377,SHP-77,ACH-000790,CVCL_1693,Lung,KMT2D,Hom,Missense,p.Q3950R,,Suppressor
+378,SHP-77,ACH-000790,CVCL_1693,Lung,KRAS,Hom,Missense,p.G12V,GoF,Oncogene
+379,SHP-77,ACH-000790,CVCL_1693,Lung,RAC1,Het,Missense,p.Y32C,,Oncogene
+380,SHP-77,ACH-000790,CVCL_1693,Lung,SETD1B,Het,Missense,p.T482M,,Suppressor
+381,SHP-77,ACH-000790,CVCL_1693,Lung,TP53,Hom,Missense,p.C176W,LoF,Suppressor
+382,SW 900,ACH-000669,CVCL_1731,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+383,SW 900,ACH-000669,CVCL_1731,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+384,SW 900,ACH-000669,CVCL_1731,Lung,KMT2D,Hom,Stopgain,p.K5522*,LoF,Suppressor
+385,SW 900,ACH-000669,CVCL_1731,Lung,KRAS,Het,Missense,p.G12V,GoF,Oncogene
+386,SW 900,ACH-000669,CVCL_1731,Lung,SMAD3,Hom,Missense,p.K334E,LoF,Suppressor
+387,SW 900,ACH-000669,CVCL_1731,Lung,TP53,Hom,Stopgain,p.Q167*,LoF,Suppressor
+388,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,ARID1A,Het,Missense,p.P1723L,,Suppressor
+389,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,ARID1A,Hom,Stopgain,p.Q321*,LoF,Suppressor
+390,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+391,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+392,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
+393,MIA PaCa-2,ACH-000601,CVCL_0428,Pancreas,TP53,Hom,Missense,p.R248W,LoF,Suppressor
+394,HCT15,ACH-000997,CVCL_0292,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+395,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.E2550Q,,Suppressor
+396,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Hom,Frameshift,p.I1417fs,LoF,Suppressor
+397,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.I1779M,,Suppressor
+398,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.K1561N,,Suppressor
+399,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.K993N,,Suppressor
+400,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Stopgain,p.R2166*,LoF,Suppressor
+401,HCT15,ACH-000997,CVCL_0292,Bowel,APC,Het,Missense,p.R727M,LoF,Suppressor
+402,HCT15,ACH-000997,CVCL_0292,Bowel,ARID1A,Het,Missense,p.R270H,,Suppressor
+403,HCT15,ACH-000997,CVCL_0292,Bowel,ATM,Het,Missense,p.E586D,,Suppressor
+404,HCT15,ACH-000997,CVCL_0292,Bowel,B2M,Het,Stopgain,p.Y30*,LoF,Suppressor
+405,HCT15,ACH-000997,CVCL_0292,Bowel,B2M,Het,Splice_site,,LoF,Suppressor
+406,HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Missense,p.A487V,,Suppressor
+407,HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
+408,HCT15,ACH-000997,CVCL_0292,Bowel,BRCA2,Het,Missense,p.R2784Q,LoF,Suppressor
+409,HCT15,ACH-000997,CVCL_0292,Bowel,CHEK2,Het,Missense,p.A247D,LoF,Suppressor
+410,HCT15,ACH-000997,CVCL_0292,Bowel,CHEK2,Het,Missense,p.R145W,LoF,Suppressor
+411,HCT15,ACH-000997,CVCL_0292,Bowel,EP300,Hom,Stopgain,p.E1014*,LoF,Suppressor
+412,HCT15,ACH-000997,CVCL_0292,Bowel,ERBB3,Het,Missense,p.R667H,,Oncogene
+413,HCT15,ACH-000997,CVCL_0292,Bowel,GNAS,Het,Missense,p.K338N,,Oncogene
+414,HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.E1517D,,Suppressor
+415,HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.P1152H,,Suppressor
+416,HCT15,ACH-000997,CVCL_0292,Bowel,KMT2D,Het,Missense,p.P1931H,,Suppressor
+417,HCT15,ACH-000997,CVCL_0292,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
+418,HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Frameshift,p.D1171fs,LoF,Suppressor
+419,HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Frameshift,p.L290fs,LoF,Suppressor
+420,HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Missense,p.R1172del,,Suppressor
+421,HCT15,ACH-000997,CVCL_0292,Bowel,MSH6,Het,Missense,p.T1189I,LoF,Suppressor
+422,HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.A2596V,,Suppressor
+423,HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.A74D,,Suppressor
+424,HCT15,ACH-000997,CVCL_0292,Bowel,NF1,Het,Missense,p.P2456S,,Suppressor
+425,HCT15,ACH-000997,CVCL_0292,Bowel,PIK3CA,Het,Missense,p.D549N,GoF,Oncogene
+426,HCT15,ACH-000997,CVCL_0292,Bowel,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
+427,HCT15,ACH-000997,CVCL_0292,Bowel,PIK3R1,Het,Missense,p.P312L,,Suppressor
+428,HCT15,ACH-000997,CVCL_0292,Bowel,POLE,Het,Missense,p.A1375V,,Suppressor
+429,HCT15,ACH-000997,CVCL_0292,Bowel,PRDM2,Het,Stopgain,p.E1259*,LoF,Suppressor
+430,HCT15,ACH-000997,CVCL_0292,Bowel,PRDM2,Het,Stopgain,p.Q1699*,LoF,Suppressor
+431,HCT15,ACH-000997,CVCL_0292,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+432,HCT15,ACH-000997,CVCL_0292,Bowel,RNF43,Het,Missense,p.L214M,,Suppressor
+433,HCT15,ACH-000997,CVCL_0292,Bowel,SETD1B,Het,Missense,p.D159N,,Suppressor
+434,HCT15,ACH-000997,CVCL_0292,Bowel,SETD1B,Het,Missense,p.Q780H,LoF,Suppressor
+435,HCT15,ACH-000997,CVCL_0292,Bowel,SMARCA4,Het,Missense,p.R885C,LoF,Suppressor
+436,HCT15,ACH-000997,CVCL_0292,Bowel,TGFBR2,Het,Missense,p.L452P,LoF,Suppressor
+437,HCT15,ACH-000997,CVCL_0292,Bowel,TP53,Het,Missense,p.S241F,LoF,Suppressor
+438,HCT15,ACH-000997,CVCL_0292,Bowel,TP53,Het,Splice_site,,LoF,Suppressor
+439,HCT15,ACH-000997,CVCL_0292,Bowel,WNK2,Het,Missense,p.V1971M,,Suppressor
+440,HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Frameshift,p.E763fs,LoF,Suppressor
+441,HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.P1707H,,Suppressor
+442,HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.P3069T,LoF,Suppressor
+443,HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.R1402C,LoF,Suppressor
+444,HCT15,ACH-000997,CVCL_0292,Bowel,ZFHX3,Het,Missense,p.S1180N,,Suppressor
+445,CFPAC-1,ACH-000138,CVCL_1119,Pancreas,KRAS,Het,Missense,p.G12V,GoF,Oncogene
+446,CFPAC-1,ACH-000138,CVCL_1119,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
+447,CFPAC-1,ACH-000138,CVCL_1119,Pancreas,TP53,Hom,Missense,p.C242R,LoF,Suppressor
+448,AsPC-1,ACH-000222,CVCL_0152,Pancreas,CDKN2A,Het,Frameshift,p.L27fs,LoF,Suppressor
+449,AsPC-1,ACH-000222,CVCL_0152,Pancreas,FBXW7,Het,Missense,p.R385C,LoF,Suppressor
+450,AsPC-1,ACH-000222,CVCL_0152,Pancreas,KRAS,Hom,Missense,p.G12D,GoF,Oncogene
+451,AsPC-1,ACH-000222,CVCL_0152,Pancreas,RNF43,Hom,Stopgain,p.S720*,LoF,Suppressor
+452,AsPC-1,ACH-000222,CVCL_0152,Pancreas,SMAD4,Hom,Missense,p.R100T,LoF,Suppressor
+453,AsPC-1,ACH-000222,CVCL_0152,Pancreas,TP53,Hom,Frameshift,p.C135fs,LoF,Suppressor
+454,Panc 02.13,ACH-000031,CVCL_1634,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+455,Panc 02.13,ACH-000031,CVCL_1634,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+456,Panc 02.13,ACH-000031,CVCL_1634,Pancreas,KRAS,Het,Missense,p.Q61R,GoF,Oncogene
+457,Panc 02.13,ACH-000031,CVCL_1634,Pancreas,SMARCA4,Het,Missense,p.T910M,LoF,Suppressor
+458,Panc 02.13,ACH-000031,CVCL_1634,Pancreas,TP53,Hom,Missense,p.R273C,LoF,Suppressor
+459,Hs 766T,ACH-000178,CVCL_0334,Pancreas,ARID1A,Het,Stopgain,p.Q538*,LoF,Suppressor
+460,Hs 766T,ACH-000178,CVCL_0334,Pancreas,CDKN2A,Hom,Splice_site,,LoF,Suppressor
+461,Hs 766T,ACH-000178,CVCL_0334,Pancreas,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
+462,Hs 766T,ACH-000178,CVCL_0334,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
+463,BxPC-3,ACH-000535,CVCL_0186,Pancreas,BRAF,Het,Missense,p.V487_492NA,,Oncogene
+464,BxPC-3,ACH-000535,CVCL_0186,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+465,BxPC-3,ACH-000535,CVCL_0186,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+466,BxPC-3,ACH-000535,CVCL_0186,Pancreas,EP300,Het,Stopgain,p.R397*,LoF,Suppressor
+467,BxPC-3,ACH-000535,CVCL_0186,Pancreas,RNF43,Hom,Missense,p.S495Y,,Suppressor
+468,BxPC-3,ACH-000535,CVCL_0186,Pancreas,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
+469,BxPC-3,ACH-000535,CVCL_0186,Pancreas,SMARCB1,Hom,Deletion,DEL,LoF,Suppressor
+470,BxPC-3,ACH-000535,CVCL_0186,Pancreas,TP53,Hom,Missense,p.Y220C,LoF,Suppressor
+471,PANC-1,ACH-000164,CVCL_0480,Pancreas,AKT2,,Gain,GAIN,GoF,Oncogene
+472,PANC-1,ACH-000164,CVCL_0480,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+473,PANC-1,ACH-000164,CVCL_0480,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+474,PANC-1,ACH-000164,CVCL_0480,Pancreas,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+475,PANC-1,ACH-000164,CVCL_0480,Pancreas,TP53,Hom,Missense,p.R273H,LoF,Suppressor
+476,KLE,ACH-000293,CVCL_1329,Uterus,AKT2,,Gain,GAIN,GoF,Oncogene
+477,KLE,ACH-000293,CVCL_1329,Uterus,CCNE1,,Gain,GAIN,GoF,Oncogene
+478,KLE,ACH-000293,CVCL_1329,Uterus,FBXW7,Het,Missense,p.R399Q,LoF,Suppressor
+479,KLE,ACH-000293,CVCL_1329,Uterus,KRAS,,Gain,GAIN,GoF,Oncogene
+480,KLE,ACH-000293,CVCL_1329,Uterus,TP53,Hom,Missense,p.R175H,LoF,Suppressor
+481,BT-474,ACH-000927,CVCL_0179,Breast,ACVR2A,Het,Missense,p.S17F,,Suppressor
+482,BT-474,ACH-000927,CVCL_0179,Breast,ATM,Het,Missense,p.E2468K,LoF,Suppressor
+483,BT-474,ACH-000927,CVCL_0179,Breast,BRCA2,Het,Stopgain,p.S3094*,LoF,Suppressor
+484,BT-474,ACH-000927,CVCL_0179,Breast,ERBB2,,Gain,GAIN,GoF,Oncogene
+485,BT-474,ACH-000927,CVCL_0179,Breast,HNF1A,Het,Stopgain,p.Q495*,LoF,Suppressor
+486,BT-474,ACH-000927,CVCL_0179,Breast,KMT2D,Het,Missense,p.E1623K,,Suppressor
+487,BT-474,ACH-000927,CVCL_0179,Breast,LASP1,,Gain,GAIN,GoF,Oncogene
+488,BT-474,ACH-000927,CVCL_0179,Breast,MAPK1,Het,Missense,p.H61Q,,Oncogene
+489,BT-474,ACH-000927,CVCL_0179,Breast,PIK3CA,Het,Missense,p.K111N,GoF,Oncogene
+490,BT-474,ACH-000927,CVCL_0179,Breast,TGFBR2,Het,Missense,p.M36I,,Suppressor
+491,BT-474,ACH-000927,CVCL_0179,Breast,TP53,Hom,Missense,p.E285K,LoF,Suppressor
+492,BT-474,ACH-000927,CVCL_0179,Breast,WNK2,Het,Missense,p.E398Q,,Suppressor
+493,SW48,ACH-000958,CVCL_1724,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+494,SW48,ACH-000958,CVCL_1724,Bowel,APC,Het,Missense,p.R2714C,,Suppressor
+495,SW48,ACH-000958,CVCL_1724,Bowel,ARID1A,Het,Frameshift,p.A339fs,LoF,Suppressor
+496,SW48,ACH-000958,CVCL_1724,Bowel,B2M,Het,Stopgain,p.Q22*,LoF,Suppressor
+497,SW48,ACH-000958,CVCL_1724,Bowel,B2M,Het,Frameshift,p.V69fs,LoF,Suppressor
+498,SW48,ACH-000958,CVCL_1724,Bowel,BRCA2,Het,Frameshift,p.K1691fs,LoF,Suppressor
+499,SW48,ACH-000958,CVCL_1724,Bowel,BRCA2,Het,Frameshift,p.N1784fs,LoF,Suppressor
+500,SW48,ACH-000958,CVCL_1724,Bowel,CTNNB1,Het,Missense,p.S33Y,GoF,Oncogene
+501,SW48,ACH-000958,CVCL_1724,Bowel,EGFR,Het,Missense,p.G674S,GoF,Oncogene
+502,SW48,ACH-000958,CVCL_1724,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
+503,SW48,ACH-000958,CVCL_1724,Bowel,EP300,Het,Missense,p.T594M,LoF,Suppressor
+504,SW48,ACH-000958,CVCL_1724,Bowel,FBXW7,Het,Frameshift,p.S588fs,LoF,Suppressor
+505,SW48,ACH-000958,CVCL_1724,Bowel,KMT2D,Het,Stopgain,p.R4904*,LoF,Suppressor
+506,SW48,ACH-000958,CVCL_1724,Bowel,KMT2D,Het,Frameshift,p.R755fs,LoF,Suppressor
+507,SW48,ACH-000958,CVCL_1724,Bowel,MAP2K1,Het,Missense,p.D175G,,Oncogene
+508,SW48,ACH-000958,CVCL_1724,Bowel,MAP2K1,Het,Missense,p.Q56P,GoF,Oncogene
+509,SW48,ACH-000958,CVCL_1724,Bowel,PIK3CA,Het,Missense,p.G914R,GoF,Oncogene
+510,SW48,ACH-000958,CVCL_1724,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+511,SW48,ACH-000958,CVCL_1724,Bowel,RNF43,Het,Frameshift,p.V299fs,LoF,Suppressor
+512,SW48,ACH-000958,CVCL_1724,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
+513,SW48,ACH-000958,CVCL_1724,Bowel,SMARCA4,Het,Missense,p.A703V,,Suppressor
+514,SW48,ACH-000958,CVCL_1724,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
+515,SW48,ACH-000958,CVCL_1724,Bowel,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
+516,LS411N,ACH-000985,CVCL_1385,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+517,LS411N,ACH-000985,CVCL_1385,Bowel,APC,Het,Stopgain,p.Q789*,LoF,Suppressor
+518,LS411N,ACH-000985,CVCL_1385,Bowel,APC,Het,Frameshift,p.T1556fs,LoF,Suppressor
+519,LS411N,ACH-000985,CVCL_1385,Bowel,ARID1A,Het,Frameshift,p.P1326fs,LoF,Suppressor
+520,LS411N,ACH-000985,CVCL_1385,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+521,LS411N,ACH-000985,CVCL_1385,Bowel,BRCA2,Het,Missense,p.E3111K,LoF,Suppressor
+522,LS411N,ACH-000985,CVCL_1385,Bowel,CHEK2,Het,Missense,p.P85H,,Suppressor
+523,LS411N,ACH-000985,CVCL_1385,Bowel,EP300,Het,Frameshift,p.H2324fs,LoF,Suppressor
+524,LS411N,ACH-000985,CVCL_1385,Bowel,ERBB2,Het,Missense,p.E744K,,Oncogene
+525,LS411N,ACH-000985,CVCL_1385,Bowel,FBXW7,Het,Missense,p.R425H,LoF,Suppressor
+526,LS411N,ACH-000985,CVCL_1385,Bowel,GNAS,Het,Missense,p.R160C,,Oncogene
+527,LS411N,ACH-000985,CVCL_1385,Bowel,GNAS,Het,Missense,p.R356C,,Oncogene
+528,LS411N,ACH-000985,CVCL_1385,Bowel,HNF1A,Het,Missense,p.L408I,LoF,Suppressor
+529,LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Missense,p.E1018D,,Suppressor
+530,LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Missense,p.G4437V,LoF,Suppressor
+531,LS411N,ACH-000985,CVCL_1385,Bowel,KMT2D,Het,Frameshift,p.P853fs,LoF,Suppressor
+532,LS411N,ACH-000985,CVCL_1385,Bowel,MAPK3,Het,Missense,p.S172C,,Oncogene
+533,LS411N,ACH-000985,CVCL_1385,Bowel,MET,Het,Missense,p.T86I,,Oncogene
+534,LS411N,ACH-000985,CVCL_1385,Bowel,NF1,Het,Missense,p.T2784I,,Suppressor
+535,LS411N,ACH-000985,CVCL_1385,Bowel,PTEN,Het,Frameshift,p.C105fs,LoF,Suppressor
+536,LS411N,ACH-000985,CVCL_1385,Bowel,PTEN,Het,Frameshift,p.K164fs,LoF,Suppressor
+537,LS411N,ACH-000985,CVCL_1385,Bowel,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+538,LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
+539,LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Frameshift,p.K42fs,LoF,Suppressor
+540,LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Missense,p.V65A,,Suppressor
+541,LS411N,ACH-000985,CVCL_1385,Bowel,SETD1B,Het,Missense,p.V723A,LoF,Suppressor
+542,LS411N,ACH-000985,CVCL_1385,Bowel,TP53,Hom,Stopgain,p.Y126*,LoF,Suppressor
+543,LS411N,ACH-000985,CVCL_1385,Bowel,WNK2,Het,Splice_site,p.S612S,LoF,Suppressor
+544,LS411N,ACH-000985,CVCL_1385,Bowel,WNK2,Het,Splice_site,,LoF,Suppressor
+545,LS411N,ACH-000985,CVCL_1385,Bowel,ZFHX3,Het,Missense,p.C3029Y,LoF,Suppressor
+546,LS411N,ACH-000985,CVCL_1385,Bowel,ZFHX3,Het,Missense,p.P802L,,Suppressor
+547,HOP62,ACH-000861,CVCL_1285,Lung,B2M,Het,Missense,p.E70Q,,Suppressor
+548,HOP62,ACH-000861,CVCL_1285,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+549,HOP62,ACH-000861,CVCL_1285,Lung,MSH6,Het,Missense,p.E221D,,Suppressor
+550,HOP62,ACH-000861,CVCL_1285,Lung,POLE,Het,Missense,p.K604N,,Suppressor
+551,HOP62,ACH-000861,CVCL_1285,Lung,RAF1,Het,Missense,p.R143Q,,Oncogene
+552,HOP62,ACH-000861,CVCL_1285,Lung,TERT,Het,Promoter,1-124C>T,GoF,Oncogene
+553,HOP62,ACH-000861,CVCL_1285,Lung,TP53,Hom,Splice_site,,LoF,Suppressor
+554,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,APC,Het,Missense,p.S770P,,Suppressor
+555,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,ERBB2,Het,Missense,p.R678Q,GoF,Oncogene
+556,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,FGFR3,Het,Missense,p.K651E,GoF,Oncogene
+557,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,PIK3CA,Het,Missense,p.P124L,,Oncogene
+558,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,PTEN,Hom,Frameshift,p.N212fs,LoF,Suppressor
+559,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,RB1,Hom,Splice_site,,LoF,Suppressor
+560,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TERT,,Promoter,1-124C>T,GoF,Oncogene
+561,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TP53,Het,Missense,p.E271K,LoF,Suppressor
+562,J82,ACH-000396,CVCL_0359,Bladder/Urinary Tract,TP53,Het,Missense,p.K320N,LoF,Suppressor
+563,CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,ARID1A,Het,Missense,p.P1144T,,Suppressor
+564,CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,PTEN,Hom,Missense,p.L112R,LoF,Suppressor
+565,CCF-STTG1,ACH-000329,CVCL_1118,CNS/Brain,PTPN11,Het,Missense,p.R498W,GoF,Oncogene
+566,BT-20,ACH-000536,CVCL_0178,Breast,BRCA2,Hom,Missense,p.T3357R,,Suppressor
+567,BT-20,ACH-000536,CVCL_0178,Breast,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+568,BT-20,ACH-000536,CVCL_0178,Breast,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+569,BT-20,ACH-000536,CVCL_0178,Breast,EGFR,,Gain,GAIN,GoF,Oncogene
+570,BT-20,ACH-000536,CVCL_0178,Breast,NRAS,,Gain,GAIN,GoF,Oncogene
+571,BT-20,ACH-000536,CVCL_0178,Breast,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
+572,BT-20,ACH-000536,CVCL_0178,Breast,PIK3CA,Het,Missense,p.P539R,GoF,Oncogene
+573,BT-20,ACH-000536,CVCL_0178,Breast,RB1,Hom,Missense,p.I388S,LoF,Suppressor
+574,BT-20,ACH-000536,CVCL_0178,Breast,RB1,Het,Missense,p.P515L,LoF,Suppressor
+575,BT-20,ACH-000536,CVCL_0178,Breast,TP53,Hom,Missense,p.K132Q,LoF,Suppressor
+576,DU4475,ACH-000258,CVCL_1183,Breast,APC,Hom,Stopgain,p.E1577*,LoF,Suppressor
+577,DU4475,ACH-000258,CVCL_1183,Breast,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+578,DU4475,ACH-000258,CVCL_1183,Breast,RB1,Hom,Deletion,DEL,LoF,Suppressor
+579,DU4475,ACH-000258,CVCL_1183,Breast,SETD1B,Het,Missense,p.Q1402R,,Suppressor
+580,DU4475,ACH-000258,CVCL_1183,Breast,ZFHX3,Het,Missense,p.A2398D,,Suppressor
+581,LS 180,ACH-000957,CVCL_0397,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+582,LS 180,ACH-000957,CVCL_0397,Bowel,APC,Het,Missense,p.R1788C,,Suppressor
+583,LS 180,ACH-000957,CVCL_0397,Bowel,ARID1A,Het,Frameshift,p.K1094fs,LoF,Suppressor
+584,LS 180,ACH-000957,CVCL_0397,Bowel,BRAF,Het,Missense,p.D211G,,Oncogene
+585,LS 180,ACH-000957,CVCL_0397,Bowel,BRCA2,Het,Frameshift,p.T3033fs,LoF,Suppressor
+586,LS 180,ACH-000957,CVCL_0397,Bowel,CTNNB1,Hom,Missense,p.S45F,GoF,Oncogene
+587,LS 180,ACH-000957,CVCL_0397,Bowel,EP300,Het,Missense,p.G30V,,Suppressor
+588,LS 180,ACH-000957,CVCL_0397,Bowel,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
+589,LS 180,ACH-000957,CVCL_0397,Bowel,JAK1,Het,Missense,p.R681W,,Oncogene
+590,LS 180,ACH-000957,CVCL_0397,Bowel,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+591,LS 180,ACH-000957,CVCL_0397,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
+592,LS 180,ACH-000957,CVCL_0397,Bowel,PRDM2,Het,Frameshift,p.V1490fs,LoF,Suppressor
+593,LS 180,ACH-000957,CVCL_0397,Bowel,PTEN,Het,Missense,p.I67K,LoF,Suppressor
+594,LS 180,ACH-000957,CVCL_0397,Bowel,RNF43,Het,Missense,p.K108E,,Suppressor
+595,LS 180,ACH-000957,CVCL_0397,Bowel,RNF43,Het,Missense,p.R389H,,Suppressor
+596,LS 180,ACH-000957,CVCL_0397,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
+597,LS 180,ACH-000957,CVCL_0397,Bowel,SETD1B,Het,Frameshift,p.Q1589fs,LoF,Suppressor
+598,LS 180,ACH-000957,CVCL_0397,Bowel,STK11,Het,Missense,p.I46T,LoF,Suppressor
+599,LS 180,ACH-000957,CVCL_0397,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
+600,LS 180,ACH-000957,CVCL_0397,Bowel,WNK2,Het,Missense,p.A1529T,,Suppressor
+601,LS 180,ACH-000957,CVCL_0397,Bowel,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
+602,LS 180,ACH-000957,CVCL_0397,Bowel,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
+603,LS 180,ACH-000957,CVCL_0397,Bowel,ZFHX3,Het,Missense,p.D3699G,LoF,Suppressor
+604,COLO 201,ACH-000253,CVCL_1987,Bowel,APC,Hom,Frameshift,p.T1556fs,LoF,Suppressor
+605,COLO 201,ACH-000253,CVCL_1987,Bowel,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+606,COLO 201,ACH-000253,CVCL_1987,Bowel,CTNNB1,Hom,Missense,p.N287S,,Oncogene
+607,COLO 201,ACH-000253,CVCL_1987,Bowel,GNAS,Het,Missense,p.S95I,,Oncogene
+608,COLO 201,ACH-000253,CVCL_1987,Bowel,MTOR,Het,Missense,p.P1193L,,Oncogene
+609,COLO 201,ACH-000253,CVCL_1987,Bowel,TP53,Hom,Frameshift,p.Y103fs,LoF,Suppressor
+610,COLO 201,ACH-000253,CVCL_1987,Bowel,TP53,Hom,Frameshift,p.Y107fs,LoF,Suppressor
+611,HepG2/C3A,ACH-001021,CVCL_1098,Liver,ATM,Het,Missense,p.V2906I,,Suppressor
+612,HepG2/C3A,ACH-001021,CVCL_1098,Liver,EGFR,Het,Missense,p.C186S,,Oncogene
+613,HepG2/C3A,ACH-001021,CVCL_1098,Liver,ERBB3,Het,Missense,p.R421K,,Oncogene
+614,HepG2/C3A,ACH-001021,CVCL_1098,Liver,NRAS,Het,Missense,p.Q61L,GoF,Oncogene
+615,HepG2/C3A,ACH-001021,CVCL_1098,Liver,TERT,,Promoter,1-124C>T,GoF,Oncogene
+616,RPMI-7951,ACH-000348,CVCL_1666,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+617,RPMI-7951,ACH-000348,CVCL_1666,Skin,CDKN2A,Hom,Missense,p.L16R,LoF,Suppressor
+618,RPMI-7951,ACH-000348,CVCL_1666,Skin,PTEN,Hom,Deletion,DEL,LoF,Suppressor
+619,RPMI-7951,ACH-000348,CVCL_1666,Skin,TERT,,Promoter,242_243CC>TT,,Oncogene
+620,RPMI-7951,ACH-000348,CVCL_1666,Skin,TP53,Hom,Stopgain,p.S166*,LoF,Suppressor
+621,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ACVR2A,Het,Frameshift,p.K437fs,LoF,Suppressor
+622,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ARID1A,Het,Frameshift,p.Y551fs,LoF,Suppressor
+623,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,CDKN2B,Het,Missense,p.A23V,,Suppressor
+624,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,FBXW7,Het,Missense,p.G104V,,Suppressor
+625,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KMT2D,Het,Missense,p.G4397V,,Suppressor
+626,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KMT2D,Het,Missense,p.P4209Q,,Suppressor
+627,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,KRAS,Het,Missense,p.G13C,GoF,Oncogene
+628,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,MSH6,Het,Missense,p.A35T,,Suppressor
+629,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,NF1,Het,Frameshift,p.P678fs,LoF,Suppressor
+630,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PIK3CA,Het,Missense,p.H1047Y,GoF,Oncogene
+631,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,POLE,Het,Missense,p.D2166N,,Suppressor
+632,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,POLE,Het,Missense,p.S828Y,LoF,Suppressor
+633,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PRDM2,Het,Missense,p.E278D,,Suppressor
+634,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,PTEN,Het,Frameshift,p.K267fs,LoF,Suppressor
+635,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,RNF43,Het,Missense,p.C298Y,LoF,Suppressor
+636,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+637,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,SETD1B,Het,Missense,p.E1078D,,Suppressor
+638,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,SMARCA4,Het,Stopgain,p.E419*,LoF,Suppressor
+639,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,STK11,Hom,Frameshift,p.P281fs,LoF,Suppressor
+640,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Stopgain,p.G1139*,LoF,Suppressor
+641,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Missense,p.L71P,,Suppressor
+642,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,WNK2,Het,Missense,p.S1520N,,Suppressor
+643,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ZFHX3,Het,Frameshift,p.A3407fs,LoF,Suppressor
+644,TOV-21G,ACH-000885,CVCL_3613,Ovary/Fallopian Tube,ZFHX3,Het,Missense,p.P2787L,,Suppressor
+645,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,EP300,Hom,Frameshift,p.K1488fs,LoF,Suppressor
+646,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+647,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,NF1,Het,Missense,p.G1417S,LoF,Suppressor
+648,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,RNF43,Hom,Frameshift,p.M18fs,LoF,Suppressor
+649,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,TGFBR2,Hom,Frameshift,p.S156fs,LoF,Suppressor
+650,Panc 10.05,ACH-000060,CVCL_1639,Pancreas,TP53,Hom,Missense,p.I255N,LoF,Suppressor
+651,HCT116,ACH-000971,CVCL_0291,Bowel,ABL1,Het,Missense,p.Y276C,,Oncogene
+652,HCT116,ACH-000971,CVCL_0291,Bowel,ACVR2A,Hom,Frameshift,p.K437fs,LoF,Suppressor
+653,HCT116,ACH-000971,CVCL_0291,Bowel,ATM,Het,Missense,p.A1127V,,Suppressor
+654,HCT116,ACH-000971,CVCL_0291,Bowel,BRCA2,Het,Frameshift,p.I2675fs,LoF,Suppressor
+655,HCT116,ACH-000971,CVCL_0291,Bowel,CDKN2A,Het,Frameshift,p.E33fs,LoF,Suppressor
+656,HCT116,ACH-000971,CVCL_0291,Bowel,CDKN2A,Het,Frameshift,p.R24fs,LoF,Suppressor
+657,HCT116,ACH-000971,CVCL_0291,Bowel,CHEK2,Het,Missense,p.L355P,LoF,Suppressor
+658,HCT116,ACH-000971,CVCL_0291,Bowel,CTNNB1,Het,Missense,p.S45NA,,Oncogene
+659,HCT116,ACH-000971,CVCL_0291,Bowel,EP300,Het,Frameshift,p.M1470fs,LoF,Suppressor
+660,HCT116,ACH-000971,CVCL_0291,Bowel,EP300,Het,Frameshift,p.N1700fs,LoF,Suppressor
+661,HCT116,ACH-000971,CVCL_0291,Bowel,GNAS,Het,Missense,p.Y318C,,Oncogene
+662,HCT116,ACH-000971,CVCL_0291,Bowel,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
+663,HCT116,ACH-000971,CVCL_0291,Bowel,KMT2D,Het,Frameshift,p.R2443fs,LoF,Suppressor
+664,HCT116,ACH-000971,CVCL_0291,Bowel,KMT2D,Het,Missense,p.V160M,LoF,Suppressor
+665,HCT116,ACH-000971,CVCL_0291,Bowel,KRAS,Het,Missense,p.G13D,GoF,Oncogene
+666,HCT116,ACH-000971,CVCL_0291,Bowel,NF1,Het,Missense,p.P388T,LoF,Suppressor
+667,HCT116,ACH-000971,CVCL_0291,Bowel,PIK3CA,Het,Missense,p.H1047R,GoF,Oncogene
+668,HCT116,ACH-000971,CVCL_0291,Bowel,PRDM2,Hom,Frameshift,p.V1490fs,LoF,Suppressor
+669,HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
+670,HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Het,Frameshift,p.R1623fs,LoF,Suppressor
+671,HCT116,ACH-000971,CVCL_0291,Bowel,SETD1B,Het,Frameshift,p.S1055fs,LoF,Suppressor
+672,HCT116,ACH-000971,CVCL_0291,Bowel,SMARCA4,Het,Missense,p.L1163P,LoF,Suppressor
+673,HCT116,ACH-000971,CVCL_0291,Bowel,SMARCA4,Het,Frameshift,p.S122fs,LoF,Suppressor
+674,HCT116,ACH-000971,CVCL_0291,Bowel,TGFBR2,Hom,Frameshift,p.K128fs,LoF,Suppressor
+675,HCT116,ACH-000971,CVCL_0291,Bowel,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
+676,HCT116,ACH-000971,CVCL_0291,Bowel,WNK2,Het,Frameshift,p.H758fs,LoF,Suppressor
+677,HCT116,ACH-000971,CVCL_0291,Bowel,ZFHX3,Het,Missense,p.G3519S,,Suppressor
+678,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,ATM,Het,Missense,p.E2351G,LoF,Suppressor
+679,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+680,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+681,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,KRAS,Het,Missense,p.G12V,GoF,Oncogene
+682,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,TP53,Hom,Splice_site,375+5G>T,LoF,Suppressor
+683,Panc 03.27,ACH-000139,CVCL_1635,Pancreas,ZFHX3,Hom,Missense,p.P802A,,Suppressor
+684,Hs 852.T,ACH-000274,CVCL_0950,Skin,CCND1,,Gain,GAIN,GoF,Oncogene
+685,Hs 852.T,ACH-000274,CVCL_0950,Skin,EGFR,,Gain,GAIN,GoF,Oncogene
+686,Hs 852.T,ACH-000274,CVCL_0950,Skin,FGFR3,,Gain,GAIN,GoF,Oncogene
+687,Hs 852.T,ACH-000274,CVCL_0950,Skin,NRAS,Het,Missense,p.G12V,GoF,Oncogene
+688,Hs 852.T,ACH-000274,CVCL_0950,Skin,POLE,Het,Missense,p.R2159H,,Suppressor
+689,Hs 852.T,ACH-000274,CVCL_0950,Skin,TERT,,Gain,GAIN,GoF,Oncogene
+690,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CDKN2A,Het,Missense,p.D23P,,Suppressor
+691,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CDKN2B,Het,Missense,p.D76A,LoF,Suppressor
+692,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,CTNNB1,Het,Missense,p.G34E,GoF,Oncogene
+693,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Stopgain,p.E1025*,LoF,Suppressor
+694,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Stopgain,p.E643*,LoF,Suppressor
+695,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,EP300,Het,Missense,p.K350R,LoF,Suppressor
+696,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,GNAS,Het,Missense,p.F219V,,Oncogene
+697,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+698,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,NF1,Het,Missense,p.E1438G,LoF,Suppressor
+699,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PIK3CA,Het,Missense,p.E453K,GoF,Oncogene
+700,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PIK3CA,Het,Missense,p.E545A,GoF,Oncogene
+701,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,PRDM2,Het,Missense,p.P1326S,,Suppressor
+702,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,SOS1,Het,Missense,p.E783G,,Oncogene
+703,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,XPO1,Het,Missense,p.C585F,,Oncogene
+704,AGS,ACH-000880,CVCL_0139,Esophagus/Stomach,ZFHX3,Het,Missense,p.F3474L,LoF,Suppressor
+705,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,ERBB2,,Gain,GAIN,GoF,Oncogene
+706,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,ERBB3,,Missense,p.T757K,,Oncogene
+707,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,KMT2D,Het,Missense,p.S537F,,Suppressor
+708,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,LASP1,,Gain,GAIN,GoF,Oncogene
+709,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,SETD1B,Het,Missense,p.Q1589P,,Suppressor
+710,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,SMAD4,Hom,Deletion,DEL,LoF,Suppressor
+711,NCI-N87,ACH-000427,CVCL_1603,Esophagus/Stomach,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
+712,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,ARID1A,Hom,Deletion,DEL,LoF,Suppressor
+713,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,BRCA2,Het,Missense,p.E2292A,LoF,Suppressor
+714,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,CDKN2A,Hom,Stopgain,p.R29*,LoF,Suppressor
+715,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,MET,,Gain,GAIN,GoF,Oncogene
+716,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,STK11,Het,Missense,p.P149L,LoF,Suppressor
+717,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,TP53,,Missense,p.G262_269NA,,Suppressor
+718,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,TP53,Het,Splice_site,,LoF,Suppressor
+719,SNU-5,ACH-000303,CVCL_0078,Esophagus/Stomach,ZFHX3,Hom,Missense,p.S1608G,,Suppressor
+720,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ACVR2A,Het,Missense,p.A349T,,Suppressor
+721,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ACVR2A,Het,Missense,p.L329M,LoF,Suppressor
+722,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Missense,p.G1544C,,Suppressor
+723,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Stopgain,p.Q1618*,LoF,Suppressor
+724,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Stopgain,p.Q1898*,LoF,Suppressor
+725,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ARID1A,Het,Missense,p.Q404H,,Suppressor
+726,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ATM,Het,Missense,p.P2353H,LoF,Suppressor
+727,HEC-1-A,ACH-000954,CVCL_0293,Uterus,BRAF,Het,Missense,p.R682Q,,Oncogene
+728,HEC-1-A,ACH-000954,CVCL_0293,Uterus,EP300,Het,Missense,p.D1399N,LoF,Suppressor
+729,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ERBB2,Het,Missense,p.T798I,GoF,Oncogene
+730,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ERBB2,Het,Missense,p.V842I,GoF,Oncogene
+731,HEC-1-A,ACH-000954,CVCL_0293,Uterus,KMT2D,Het,Missense,p.P2641H,,Suppressor
+732,HEC-1-A,ACH-000954,CVCL_0293,Uterus,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+733,HEC-1-A,ACH-000954,CVCL_0293,Uterus,MET,Het,Missense,p.V1350D,,Oncogene
+734,HEC-1-A,ACH-000954,CVCL_0293,Uterus,MSH6,Het,Frameshift,p.F1088fs,LoF,Suppressor
+735,HEC-1-A,ACH-000954,CVCL_0293,Uterus,MSH6,Het,Splice_site,,LoF,Suppressor
+736,HEC-1-A,ACH-000954,CVCL_0293,Uterus,MTOR,Het,Missense,p.R2254M,,Oncogene
+737,HEC-1-A,ACH-000954,CVCL_0293,Uterus,NF1,Het,Missense,p.L792I,,Suppressor
+738,HEC-1-A,ACH-000954,CVCL_0293,Uterus,PIK3CA,Het,Missense,p.G1049R,GoF,Oncogene
+739,HEC-1-A,ACH-000954,CVCL_0293,Uterus,PMS2,Hom,Stopgain,p.R802*,LoF,Suppressor
+740,HEC-1-A,ACH-000954,CVCL_0293,Uterus,PRDM2,Het,Missense,p.N1324I,,Suppressor
+741,HEC-1-A,ACH-000954,CVCL_0293,Uterus,RNF43,Het,Frameshift,p.G659fs,LoF,Suppressor
+742,HEC-1-A,ACH-000954,CVCL_0293,Uterus,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
+743,HEC-1-A,ACH-000954,CVCL_0293,Uterus,SETD1B,Het,Frameshift,p.P1361fs,LoF,Suppressor
+744,HEC-1-A,ACH-000954,CVCL_0293,Uterus,SMAD4,Het,Missense,p.L344S,LoF,Suppressor
+745,HEC-1-A,ACH-000954,CVCL_0293,Uterus,SMARCA4,Het,Frameshift,p.G271fs,LoF,Suppressor
+746,HEC-1-A,ACH-000954,CVCL_0293,Uterus,TP53,Hom,Missense,p.R248Q,LoF,Suppressor
+747,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ZFHX3,Het,Stopgain,p.R1114*,LoF,Suppressor
+748,HEC-1-A,ACH-000954,CVCL_0293,Uterus,ZFHX3,Het,Frameshift,p.S2505fs,LoF,Suppressor
+749,C-33 A,ACH-001333,CVCL_1094,Cervix,ARID1A,Het,Frameshift,p.Q758fs,LoF,Suppressor
+750,C-33 A,ACH-001333,CVCL_1094,Cervix,BRCA2,Het,Missense,p.A3029T,,Suppressor
+751,C-33 A,ACH-001333,CVCL_1094,Cervix,HNF1A,Het,Frameshift,p.P291fs,LoF,Suppressor
+752,C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Frameshift,p.A2119fs,LoF,Suppressor
+753,C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Missense,p.R1614W,LoF,Suppressor
+754,C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Missense,p.R1617W,LoF,Suppressor
+755,C-33 A,ACH-001333,CVCL_1094,Cervix,KMT2D,Het,Frameshift,p.V1244fs,LoF,Suppressor
+756,C-33 A,ACH-001333,CVCL_1094,Cervix,PIK3CA,Het,Missense,p.R88Q,GoF,Oncogene
+757,C-33 A,ACH-001333,CVCL_1094,Cervix,PTEN,Het,Stopgain,p.R130*,LoF,Suppressor
+758,C-33 A,ACH-001333,CVCL_1094,Cervix,PTEN,Het,Stopgain,p.R233*,LoF,Suppressor
+759,C-33 A,ACH-001333,CVCL_1094,Cervix,RB1,Hom,Splice_site,,LoF,Suppressor
+760,C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Frameshift,p.H8fs,LoF,Suppressor
+761,C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Missense,p.R980W,,Suppressor
+762,C-33 A,ACH-001333,CVCL_1094,Cervix,SETD1B,Het,Missense,p.T482M,,Suppressor
+763,C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Missense,p.M527T,LoF,Suppressor
+764,C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Missense,p.Q1248R,LoF,Suppressor
+765,C-33 A,ACH-001333,CVCL_1094,Cervix,SMARCA4,Het,Stopgain,p.Q1537*,LoF,Suppressor
+766,C-33 A,ACH-001333,CVCL_1094,Cervix,TP53,Hom,Missense,p.R273C,LoF,Suppressor
+767,C-33 A,ACH-001333,CVCL_1094,Cervix,WNK2,Het,Missense,p.A678T,,Suppressor
+768,C-33 A,ACH-001333,CVCL_1094,Cervix,WNK2,Het,Frameshift,p.D1638fs,LoF,Suppressor
+769,C-33 A,ACH-001333,CVCL_1094,Cervix,ZFHX3,Het,Frameshift,p.R1893fs,LoF,Suppressor
+770,SK-HEP-1,ACH-000361,CVCL_0525,Liver,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+771,SK-HEP-1,ACH-000361,CVCL_0525,Liver,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+772,SK-HEP-1,ACH-000361,CVCL_0525,Liver,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+773,SK-HEP-1,ACH-000361,CVCL_0525,Liver,NF2,Het,Missense,p.I264V,,Suppressor
+774,SK-HEP-1,ACH-000361,CVCL_0525,Liver,SMARCA4,Hom,Stopgain,p.E1582*,LoF,Suppressor
+775,NCI-H1573,ACH-000916,CVCL_1478,Lung,CDKN2A,Het,Missense,p.D23P,,Suppressor
+776,NCI-H1573,ACH-000916,CVCL_1478,Lung,EGFR,,Gain,GAIN,GoF,Oncogene
+777,NCI-H1573,ACH-000916,CVCL_1478,Lung,ERBB3,Het,Missense,p.E332K,GoF,Oncogene
+778,NCI-H1573,ACH-000916,CVCL_1478,Lung,FBXW7,Het,Missense,p.V619L,,Suppressor
+779,NCI-H1573,ACH-000916,CVCL_1478,Lung,FBXW7,Het,Stopgain,p.W593*,LoF,Suppressor
+780,NCI-H1573,ACH-000916,CVCL_1478,Lung,KMT2D,Het,Missense,p.L2398P,,Suppressor
+781,NCI-H1573,ACH-000916,CVCL_1478,Lung,KMT2D,Het,Missense,p.V361F,,Suppressor
+782,NCI-H1573,ACH-000916,CVCL_1478,Lung,KRAS,Het,Missense,p.G12A,GoF,Oncogene
+783,NCI-H1573,ACH-000916,CVCL_1478,Lung,MET,,Gain,GAIN,GoF,Oncogene
+784,NCI-H1573,ACH-000916,CVCL_1478,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+785,NCI-H1573,ACH-000916,CVCL_1478,Lung,PIK3R1,Het,Stopgain,p.G71*,LoF,Suppressor
+786,NCI-H1573,ACH-000916,CVCL_1478,Lung,PTPN11,Het,Stopgain,p.R351*,,Oncogene
+787,NCI-H1573,ACH-000916,CVCL_1478,Lung,RNF43,Het,Missense,p.A605G,,Suppressor
+788,NCI-H1573,ACH-000916,CVCL_1478,Lung,SMARCA4,Hom,Stopgain,p.E1399*,LoF,Suppressor
+789,NCI-H1573,ACH-000916,CVCL_1478,Lung,STK11,Het,Missense,p.S216F,LoF,Suppressor
+790,NCI-H1573,ACH-000916,CVCL_1478,Lung,TP53,Hom,Missense,p.R248L,LoF,Suppressor
+791,SK-MEL-2,ACH-001190,CVCL_0069,Skin,CCND1,,Gain,GAIN,GoF,Oncogene
+792,SK-MEL-2,ACH-001190,CVCL_0069,Skin,EP300,Het,Missense,p.P989S,,Suppressor
+793,SK-MEL-2,ACH-001190,CVCL_0069,Skin,NRAS,Het,Missense,p.Q61R,GoF,Oncogene
+794,SK-MEL-2,ACH-001190,CVCL_0069,Skin,POLE,Het,Missense,p.T1052A,,Suppressor
+795,SK-MEL-2,ACH-001190,CVCL_0069,Skin,SETD1B,Het,Frameshift,p.L1255fs,LoF,Suppressor
+796,SK-MEL-2,ACH-001190,CVCL_0069,Skin,TERT,,Promoter,1-146C>T,GoF,Oncogene
+797,SK-MEL-2,ACH-001190,CVCL_0069,Skin,TP53,Hom,Missense,p.G245S,LoF,Suppressor
+798,SK-MEL-2,ACH-001190,CVCL_0069,Skin,ZFHX3,Het,Frameshift,p.H3611fs,LoF,Suppressor
+799,NCI-H1155,ACH-000980,CVCL_1456,Lung,APC,Het,Stopgain,p.R232*,LoF,Suppressor
+800,NCI-H1155,ACH-000980,CVCL_1456,Lung,EGFR,Het,Missense,p.R264G,,Oncogene
+801,NCI-H1155,ACH-000980,CVCL_1456,Lung,EP300,Hom,Splice_site,,LoF,Suppressor
+802,NCI-H1155,ACH-000980,CVCL_1456,Lung,KMT2D,Het,Missense,p.A3561D,,Suppressor
+803,NCI-H1155,ACH-000980,CVCL_1456,Lung,KMT2D,Het,Missense,p.V38M,,Suppressor
+804,NCI-H1155,ACH-000980,CVCL_1456,Lung,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
+805,NCI-H1155,ACH-000980,CVCL_1456,Lung,LASP1,Het,Missense,p.A209V,,Oncogene
+806,NCI-H1155,ACH-000980,CVCL_1456,Lung,MSH6,Hom,Stopgain,p.R911*,LoF,Suppressor
+807,NCI-H1155,ACH-000980,CVCL_1456,Lung,NF2,Het,Missense,p.A403T,,Suppressor
+808,NCI-H1155,ACH-000980,CVCL_1456,Lung,PIK3CA,Het,Missense,p.D843E,,Oncogene
+809,NCI-H1155,ACH-000980,CVCL_1456,Lung,PTEN,Hom,Stopgain,p.R233*,LoF,Suppressor
+810,NCI-H1155,ACH-000980,CVCL_1456,Lung,RB1,Het,Stopgain,p.R467*,LoF,Suppressor
+811,NCI-H1155,ACH-000980,CVCL_1456,Lung,SMAD4,Het,Frameshift,p.R38fs,LoF,Suppressor
+812,NCI-H1155,ACH-000980,CVCL_1456,Lung,SMARCA4,Het,Missense,p.R466L,,Suppressor
+813,NCI-H1155,ACH-000980,CVCL_1456,Lung,SMARCA4,Het,Missense,p.S1238P,LoF,Suppressor
+814,NCI-H1155,ACH-000980,CVCL_1456,Lung,TP53,Hom,Missense,p.R273H,LoF,Suppressor
+815,NCI-H1155,ACH-000980,CVCL_1456,Lung,ZFHX3,Het,Missense,p.A896T,,Suppressor
+816,NCI-H460,ACH-000463,CVCL_0459,Lung,ARID1A,Hom,Missense,p.LI1917del,,Suppressor
+817,NCI-H460,ACH-000463,CVCL_0459,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+818,NCI-H460,ACH-000463,CVCL_0459,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+819,NCI-H460,ACH-000463,CVCL_0459,Lung,KRAS,Hom,Missense,p.Q61H,GoF,Oncogene
+820,NCI-H460,ACH-000463,CVCL_0459,Lung,MAP2K1,Het,Missense,p.Y134C,,Oncogene
+821,NCI-H460,ACH-000463,CVCL_0459,Lung,MYC,,Gain,GAIN,GoF,Oncogene
+822,NCI-H460,ACH-000463,CVCL_0459,Lung,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
+823,NCI-H460,ACH-000463,CVCL_0459,Lung,STK11,Hom,Stopgain,p.Q37*,LoF,Suppressor
+824,NCI-H460,ACH-000463,CVCL_0459,Lung,ZFHX3,Het,Missense,p.P3675Q,,Suppressor
+825,NCI-H1299,ACH-000510,CVCL_0060,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+826,NCI-H1299,ACH-000510,CVCL_0060,Lung,SMARCA4,Hom,Splice_site,,LoF,Suppressor
+827,NCI-H1299,ACH-000510,CVCL_0060,Lung,SOS1,Het,Missense,p.Y215H,,Oncogene
+828,NCI-H1299,ACH-000510,CVCL_0060,Lung,TP53,Hom,Deletion,DEL,LoF,Suppressor
+829,NCI-H1299,ACH-000510,CVCL_0060,Lung,ZFHX3,Het,Missense,p.F3044V,LoF,Suppressor
+830,NCI-H661,ACH-000853,CVCL_1577,Lung,BRCA2,Het,Missense,p.G2584V,LoF,Suppressor
+831,NCI-H661,ACH-000853,CVCL_1577,Lung,CDKN2A,Hom,Splice_site,,LoF,Suppressor
+832,NCI-H661,ACH-000853,CVCL_1577,Lung,LASP1,Het,Stopgain,p.E48*,,Oncogene
+833,NCI-H661,ACH-000853,CVCL_1577,Lung,PTPN11,Het,Missense,p.N58S,,Oncogene
+834,NCI-H661,ACH-000853,CVCL_1577,Lung,SMARCA4,Hom,Frameshift,p.L1161fs,LoF,Suppressor
+835,NCI-H661,ACH-000853,CVCL_1577,Lung,TP53,Het,Missense,p.R158L,LoF,Suppressor
+836,NCI-H661,ACH-000853,CVCL_1577,Lung,TP53,Het,Missense,p.S215I,LoF,Suppressor
+837,NCI-H661,ACH-000853,CVCL_1577,Lung,WNK2,Hom,Frameshift,p.G64fs,LoF,Suppressor
+838,NCI-H661,ACH-000853,CVCL_1577,Lung,ZFHX3,Het,Missense,p.H2506P,,Suppressor
+839,NCI-H596,ACH-000628,CVCL_1571,Lung,KMT2D,Het,Missense,p.M4058V,,Suppressor
+840,NCI-H596,ACH-000628,CVCL_1571,Lung,PIK3CA,Het,Missense,p.E545K,GoF,Oncogene
+841,NCI-H596,ACH-000628,CVCL_1571,Lung,RB1,Hom,Frameshift,p.S182fs,LoF,Suppressor
+842,NCI-H596,ACH-000628,CVCL_1571,Lung,TGFBR2,Hom,Frameshift,p.S75fs,LoF,Suppressor
+843,NCI-H596,ACH-000628,CVCL_1571,Lung,TP53,Hom,Missense,p.G245C,LoF,Suppressor
+844,A-427,ACH-000757,CVCL_1055,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+845,A-427,ACH-000757,CVCL_1055,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+846,A-427,ACH-000757,CVCL_1055,Lung,CTNNB1,Hom,Missense,p.T41A,GoF,Oncogene
+847,A-427,ACH-000757,CVCL_1055,Lung,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+848,A-427,ACH-000757,CVCL_1055,Lung,POLE,Hom,Missense,p.R37L,,Suppressor
+849,A-427,ACH-000757,CVCL_1055,Lung,SMARCA4,Het,Missense,p.A1307D,LoF,Suppressor
+850,Panc 08.13,ACH-000417,CVCL_1638,Pancreas,ATM,Het,Missense,p.F1234S,LoF,Suppressor
+851,Panc 08.13,ACH-000417,CVCL_1638,Pancreas,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+852,Panc 08.13,ACH-000417,CVCL_1638,Pancreas,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+853,Panc 08.13,ACH-000417,CVCL_1638,Pancreas,KRAS,Hom,Missense,p.G12D,GoF,Oncogene
+854,Panc 08.13,ACH-000417,CVCL_1638,Pancreas,SMAD4,Hom,Frameshift,p.C123fs,LoF,Suppressor
+855,CHP-212,ACH-000120,CVCL_1125,Peripheral Nervous System,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+856,H4,ACH-000389,CVCL_1239,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+857,H4,ACH-000389,CVCL_1239,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+858,H4,ACH-000389,CVCL_1239,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
+859,H4,ACH-000389,CVCL_1239,CNS/Brain,TERT,,Promoter,1-124C>T,GoF,Oncogene
+860,A498,ACH-000555,CVCL_1056,Kidney,APC,Het,Missense,p.C1270R,LoF,Suppressor
+861,A498,ACH-000555,CVCL_1056,Kidney,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+862,A498,ACH-000555,CVCL_1056,Kidney,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+863,A498,ACH-000555,CVCL_1056,Kidney,PIK3CB,Het,Missense,p.D1067V,GoF,Oncogene
+864,A498,ACH-000555,CVCL_1056,Kidney,SMARCA4,Het,Missense,p.A923P,LoF,Suppressor
+865,A498,ACH-000555,CVCL_1056,Kidney,VHL,Hom,Frameshift,p.G144fs,LoF,Suppressor
+866,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+867,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+868,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+869,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,POLE,Het,Missense,p.V1270F,,Suppressor
+870,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
+871,SW 1088,ACH-000437,CVCL_1715,CNS/Brain,TP53,Hom,Missense,p.R273C,LoF,Suppressor
+872,BT-483,ACH-000818,CVCL_2319,Breast,APC,Het,Missense,p.T1160K,LoF,Suppressor
+873,BT-483,ACH-000818,CVCL_2319,Breast,NF1,Het,Missense,p.R1204W,LoF,Suppressor
+874,BT-483,ACH-000818,CVCL_2319,Breast,PIK3CA,Het,Missense,p.E542K,GoF,Oncogene
+875,BT-483,ACH-000818,CVCL_2319,Breast,TP53,Het,Missense,p.M246I,LoF,Suppressor
+876,BT-483,ACH-000818,CVCL_2319,Breast,WNK2,Het,Missense,p.L1162P,,Suppressor
+877,SNU-423,ACH-000493,CVCL_0366,Liver,ARID1A,Hom,Stopgain,p.G623*,LoF,Suppressor
+878,SNU-423,ACH-000493,CVCL_0366,Liver,RNF43,Het,Missense,p.I485V,,Suppressor
+879,SNU-423,ACH-000493,CVCL_0366,Liver,TERT,,Promoter,1-124C>T,GoF,Oncogene
+880,SNU-423,ACH-000493,CVCL_0366,Liver,TP53,Hom,Splice_site,,LoF,Suppressor
+881,SW 1271,ACH-000890,CVCL_1716,Lung,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+882,SW 1271,ACH-000890,CVCL_1716,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+883,SW 1271,ACH-000890,CVCL_1716,Lung,NRAS,Hom,Missense,p.Q61R,GoF,Oncogene
+884,SW 1271,ACH-000890,CVCL_1716,Lung,PMS2,Het,Missense,p.H88Y,,Suppressor
+885,SW 1271,ACH-000890,CVCL_1716,Lung,SMARCA4,Hom,Missense,p.N774K,LoF,Suppressor
+886,SW 1271,ACH-000890,CVCL_1716,Lung,TP53,Hom,Missense,p.C277F,LoF,Suppressor
+887,Hs 695T,ACH-000799,CVCL_0851,Skin,ATM,Hom,Stopgain,p.Q1825*,LoF,Suppressor
+888,Hs 695T,ACH-000799,CVCL_0851,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+889,Hs 695T,ACH-000799,CVCL_0851,Skin,BRCA2,Het,Missense,p.K2950N,,Suppressor
+890,Hs 695T,ACH-000799,CVCL_0851,Skin,NF1,Het,Stopgain,p.Q959*,LoF,Suppressor
+891,Hs 695T,ACH-000799,CVCL_0851,Skin,POLE,Het,Missense,p.V1270F,,Suppressor
+892,Hs 695T,ACH-000799,CVCL_0851,Skin,TERT,,Promoter,1-146C>T,GoF,Oncogene
+893,C32,ACH-000580,CVCL_1097,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+894,C32,ACH-000580,CVCL_1097,Skin,CDKN2A,Hom,Stoploss,Ter157Serext*13,,Suppressor
+895,C32,ACH-000580,CVCL_1097,Skin,PTEN,Hom,Deletion,DEL,LoF,Suppressor
+896,C32,ACH-000580,CVCL_1097,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene
+897,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,ATM,Het,Missense,p.S2581I,,Suppressor
+898,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,BRCA2,Het,Missense,p.G2044V,,Suppressor
+899,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,CTNNB1,,Gain,GAIN,GoF,Oncogene
+900,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,FGFR2,,Gain,GAIN,GoF,Oncogene
+901,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,KMT2D,Het,Missense,p.A3242P,,Suppressor
+902,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,KMT2D,Het,Stopgain,p.E1747*,LoF,Suppressor
+903,KATO III,ACH-000793,CVCL_0371,Esophagus/Stomach,TP53,,Deletion,DEL,LoF,Suppressor
+904,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
+905,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Missense,p.P121S,,Suppressor
+906,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ARID1A,Het,Frameshift,p.Q372fs,LoF,Suppressor
+907,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,ATM,Het,Frameshift,p.L1154fs,LoF,Suppressor
+908,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,BRCA2,Het,Missense,p.R1190W,,Suppressor
+909,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,BRCA2,Het,Frameshift,p.S309fs,LoF,Suppressor
+910,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,JAK1,Het,Frameshift,p.K860fs,,Oncogene
+911,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Frameshift,p.A2119fs,LoF,Suppressor
+912,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Missense,p.P2363del,,Suppressor
+913,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KMT2D,Het,Missense,p.R5030C,LoF,Suppressor
+914,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,KRAS,Het,Missense,p.G12D,GoF,Oncogene
+915,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,PRDM2,Het,Missense,p.S67F,LoF,Suppressor
+916,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SETD1B,Hom,Frameshift,p.H8fs,LoF,Suppressor
+917,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SMAD3,Het,Frameshift,p.V380fs,LoF,Suppressor
+918,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,SMAD4,Het,Missense,p.R265H,LoF,Suppressor
+919,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,TGFBR2,Het,Frameshift,p.S409fs,LoF,Suppressor
+920,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,WNK2,Het,Missense,p.G1850C,,Suppressor
+921,SNU-1,ACH-000932,CVCL_0099,Esophagus/Stomach,WNK2,Het,Missense,p.W547C,,Suppressor
+922,AN3 CA,ACH-000940,CVCL_0028,Uterus,ARID1A,Het,Frameshift,p.D1633fs,LoF,Suppressor
+923,AN3 CA,ACH-000940,CVCL_0028,Uterus,ARID1A,Het,Missense,p.LEMLRENT1836del,,Suppressor
+924,AN3 CA,ACH-000940,CVCL_0028,Uterus,FBXW7,Het,Missense,p.R361W,LoF,Suppressor
+925,AN3 CA,ACH-000940,CVCL_0028,Uterus,FGFR2,Het,Missense,p.K82R,GoF,Oncogene
+926,AN3 CA,ACH-000940,CVCL_0028,Uterus,FGFR2,Hom,Missense,p.N321K,GoF,Oncogene
+927,AN3 CA,ACH-000940,CVCL_0028,Uterus,HRAS,Het,Missense,p.F82L,,Oncogene
+928,AN3 CA,ACH-000940,CVCL_0028,Uterus,KMT2D,Het,Frameshift,p.P2210fs,LoF,Suppressor
+929,AN3 CA,ACH-000940,CVCL_0028,Uterus,MAPK3,Het,Missense,p.P373S,,Oncogene
+930,AN3 CA,ACH-000940,CVCL_0028,Uterus,MET,Het,Missense,p.G344R,,Oncogene
+931,AN3 CA,ACH-000940,CVCL_0028,Uterus,PIK3R1,Het,Missense,p.R557_561NA,,Suppressor
+932,AN3 CA,ACH-000940,CVCL_0028,Uterus,POLE,Het,Missense,p.S30L,,Suppressor
+933,AN3 CA,ACH-000940,CVCL_0028,Uterus,PTEN,Hom,Frameshift,p.R130fs,LoF,Suppressor
+934,AN3 CA,ACH-000940,CVCL_0028,Uterus,SETD1B,Het,Frameshift,p.P749fs,LoF,Suppressor
+935,AN3 CA,ACH-000940,CVCL_0028,Uterus,SMARCA4,Het,Missense,p.P1456L,,Suppressor
+936,AN3 CA,ACH-000940,CVCL_0028,Uterus,TERT,Het,Missense,p.D848G,,Oncogene
+937,AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Missense,p.G389W,,Suppressor
+938,AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Missense,p.R213Q,LoF,Suppressor
+939,AN3 CA,ACH-000940,CVCL_0028,Uterus,TP53,Het,Frameshift,p.S90fs,LoF,Suppressor
+940,AN3 CA,ACH-000940,CVCL_0028,Uterus,WNK2,Het,Missense,p.P702S,,Suppressor
+941,AN3 CA,ACH-000940,CVCL_0028,Uterus,ZFHX3,Het,Frameshift,p.R1893fs,LoF,Suppressor
+942,NCI-H2347,ACH-000875,CVCL_1550,Lung,B2M,Hom,Stopgain,p.Q28*,LoF,Suppressor
+943,NCI-H2347,ACH-000875,CVCL_1550,Lung,EP300,Het,Missense,p.V5L,,Suppressor
+944,NCI-H2347,ACH-000875,CVCL_1550,Lung,KRAS,Het,Missense,p.L19F,GoF,Oncogene
+945,NCI-H2347,ACH-000875,CVCL_1550,Lung,NF1,Het,Missense,p.H31L,LoF,Suppressor
+946,NCI-H2347,ACH-000875,CVCL_1550,Lung,NRAS,Hom,Missense,p.Q61R,GoF,Oncogene
+947,NCI-H2347,ACH-000875,CVCL_1550,Lung,TP53,Hom,Splice_site,p.T125T,LoF,Suppressor
+948,NCI-H2347,ACH-000875,CVCL_1550,Lung,TP53,Hom,Synonymous_splicing,Thr125Thr,,Suppressor
+949,EKVX,ACH-000706,CVCL_1195,Lung,SMARCA4,Hom,Stopgain,p.Q418*,LoF,Suppressor
+950,EKVX,ACH-000706,CVCL_1195,Lung,STK11,Hom,Missense,p.S216F,LoF,Suppressor
+951,EKVX,ACH-000706,CVCL_1195,Lung,TP53,Hom,Stopgain,p.E204*,LoF,Suppressor
+952,EKVX,ACH-000706,CVCL_1195,Lung,VHL,Het,Missense,p.S111I,,Suppressor
+953,NCI-H2087,ACH-000841,CVCL_1524,Lung,ATM,Het,Missense,p.E848Q,,Suppressor
+954,NCI-H2087,ACH-000841,CVCL_1524,Lung,ATM,Het,Missense,p.L2965F,LoF,Suppressor
+955,NCI-H2087,ACH-000841,CVCL_1524,Lung,BRAF,Het,Missense,p.L597V,GoF,Oncogene
+956,NCI-H2087,ACH-000841,CVCL_1524,Lung,MYC,,Gain,GAIN,GoF,Oncogene
+957,NCI-H2087,ACH-000841,CVCL_1524,Lung,MYC,Het,Missense,p.E54K,,Oncogene
+958,NCI-H2087,ACH-000841,CVCL_1524,Lung,NRAS,Het,Missense,p.Q61K,GoF,Oncogene
+959,NCI-H2087,ACH-000841,CVCL_1524,Lung,PRDM2,Hom,Missense,p.P619S,,Suppressor
+960,NCI-H2087,ACH-000841,CVCL_1524,Lung,RB1,Het,Splice_site,,LoF,Suppressor
+961,NCI-H2087,ACH-000841,CVCL_1524,Lung,TP53,Hom,Missense,p.V157F,LoF,Suppressor
+962,A-172,ACH-000558,CVCL_0131,CNS/Brain,ABL1,,Fusion,ABL1-CBFB,,Oncogene
+963,A-172,ACH-000558,CVCL_0131,CNS/Brain,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+964,A-172,ACH-000558,CVCL_0131,CNS/Brain,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+965,A-172,ACH-000558,CVCL_0131,CNS/Brain,PTEN,Hom,Deletion,DEL,LoF,Suppressor
+966,A-172,ACH-000558,CVCL_0131,CNS/Brain,RB1,Het,Missense,p.V852L,,Suppressor
+967,hTERT-HPNE,,CVCL_C466,Pancreas,TERT,,Transgene,,,Oncogene
+968,NCI-H23,ACH-000900,CVCL_1547,Lung,ATM,Hom,Missense,p.Q1919P,LoF,Suppressor
+969,NCI-H23,ACH-000900,CVCL_1547,Lung,KMT2D,Het,Missense,p.G3465V,,Suppressor
+970,NCI-H23,ACH-000900,CVCL_1547,Lung,KMT2D,Het,Missense,p.S4328T,,Suppressor
+971,NCI-H23,ACH-000900,CVCL_1547,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+972,NCI-H23,ACH-000900,CVCL_1547,Lung,MYC,,Gain,GAIN,GoF,Oncogene
+973,NCI-H23,ACH-000900,CVCL_1547,Lung,PMS2,Het,Missense,p.E491K,,Suppressor
+974,NCI-H23,ACH-000900,CVCL_1547,Lung,SMARCA4,Hom,Stopgain,p.1566_1567KE>N*,LoF,Suppressor
+975,NCI-H23,ACH-000900,CVCL_1547,Lung,STK11,Hom,Stopgain,p.W332*,LoF,Suppressor
+976,NCI-H23,ACH-000900,CVCL_1547,Lung,TP53,Hom,Missense,p.M246I,LoF,Suppressor
+977,NCI-H1792,ACH-000496,CVCL_1495,Lung,CDKN2A,Het,Stopgain,p.W110*,LoF,Suppressor
+978,NCI-H1792,ACH-000496,CVCL_1495,Lung,KRAS,Het,Missense,p.G12C,GoF,Oncogene
+979,NCI-H1792,ACH-000496,CVCL_1495,Lung,MYC,,Gain,GAIN,GoF,Oncogene
+980,NCI-H1792,ACH-000496,CVCL_1495,Lung,SOS1,,Gain,GAIN,GoF,Oncogene
+981,NCI-H1792,ACH-000496,CVCL_1495,Lung,TP53,Hom,Splice_site,,LoF,Suppressor
+982,NCI-H2122,ACH-000311,CVCL_1531,Lung,CDKN2A,,Deletion,DEL,LoF,Suppressor
+983,NCI-H2122,ACH-000311,CVCL_1531,Lung,CDKN2B,Hom,Deletion,DEL,LoF,Suppressor
+984,NCI-H2122,ACH-000311,CVCL_1531,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
+985,NCI-H2122,ACH-000311,CVCL_1531,Lung,MYC,,Gain,GAIN,GoF,Oncogene
+986,NCI-H2122,ACH-000311,CVCL_1531,Lung,STK11,Hom,Frameshift,p.P281fs,LoF,Suppressor
+987,NCI-H2122,ACH-000311,CVCL_1531,Lung,TP53,Het,Missense,p.C176F,LoF,Suppressor
+988,NCI-H2122,ACH-000311,CVCL_1531,Lung,TP53,Het,Missense,p.Q16L,LoF,Suppressor
+989,NCI-H2030,ACH-000521,CVCL_1517,Lung,KRAS,Hom,Missense,p.G12C,GoF,Oncogene
+990,NCI-H2030,ACH-000521,CVCL_1517,Lung,POLE,Hom,Missense,p.S780L,,Suppressor
+991,NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Stopgain,p.E317*,LoF,Suppressor
+992,NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Missense,p.E357K,,Suppressor
+993,NCI-H2030,ACH-000521,CVCL_1517,Lung,STK11,Hom,Missense,p.M392I,,Suppressor
+994,NCI-H2030,ACH-000521,CVCL_1517,Lung,TP53,Hom,Missense,p.G262V,LoF,Suppressor
+995,LOX-IMVI,ACH-000750,CVCL_1381,Skin,ARID1A,Het,Stopgain,p.Q1212*,LoF,Suppressor
+996,LOX-IMVI,ACH-000750,CVCL_1381,Skin,BRAF,Het,Missense,p.V600E,GoF,Oncogene
+997,LOX-IMVI,ACH-000750,CVCL_1381,Skin,CDKN2A,Hom,Deletion,DEL,LoF,Suppressor
+998,LOX-IMVI,ACH-000750,CVCL_1381,Skin,NF1,Het,Stopgain,p.Q1174*,LoF,Suppressor
+999,LOX-IMVI,ACH-000750,CVCL_1381,Skin,TERT,,Promoter,1-124C>T,GoF,Oncogene

data/coefficients_E-dist.csv

@@ -0,0 +1,16 @@
+Feature,Coefficient,Odds_Ratio,HC_Std_Error,z_value,p_value,CI_Lower_95,CI_Upper_95,Significant,split_seed,X_features
+const,-1.013787145504068,0.36284223790653564,0.06129156989068605,-16.540401025983908,1.8776818836532333e-61,-1.1339164150457322,-0.8936578759624036,True,432,E-dist
+max_e_distance,0.0,1.0,0.10473557938849125,0.0,1.0,-0.20527796350137847,0.20527796350137847,False,432,E-dist
+approval_rate,0.0,1.0,0.06408982281905011,0.0,1.0,-0.12561374450089152,0.12561374450089152,False,432,E-dist
+const,-1.326265472950734,0.2654668053755506,0.06772575178953655,-19.58288299363904,2.1641802722081273e-85,-1.4590055072841246,-1.1935254386173433,True,43,E-dist
+max_e_distance,-0.8354009450098836,0.4337005564942426,0.12152839666264699,-6.874121340783333,6.237310078399719e-12,-1.0735922255675694,-0.5972096644521978,True,43,E-dist
+approval_rate,0.3771145994456478,1.4580713939706058,0.06930683471580742,5.441232469957771,5.2913210579186074e-08,0.24127569952019493,0.5129534993711007,True,43,E-dist
+const,-0.9832310817188966,0.3741003950158178,0.062137267135908766,-15.823532753192055,2.1413285700413293e-56,-1.105017887403022,-0.8614442760347711,True,5235,E-dist
+approval_rate,0.6644784661772544,1.9434766681642863,0.06662214842557289,9.973837258034065,1.984116982296628e-23,0.5339014546904497,0.795055477664059,True,5235,E-dist
+max_e_distance,-0.15292946390843343,0.8581902530628214,0.1207765638141659,-1.2662180399811664,0.2054350305822502,-0.38964717916070213,0.08378825134383527,False,5235,E-dist
+const,-1.0365340401381151,0.35468186715826494,0.06028665699941084,-17.193423747948817,2.9743724525559917e-66,-1.15469371660528,-0.9183743636709503,True,332,E-dist
+max_e_distance,-0.6572514229865971,0.5182738943010444,0.11004670256356665,-5.972477209000849,2.336777993574761e-09,-0.8729389966285794,-0.44156384934461484,True,332,E-dist
+approval_rate,0.5000354359046812,1.6487796956650873,0.06385409287628752,7.830906577491628,4.843644997178721e-15,0.3748837136016821,0.6251871582076804,True,332,E-dist
+const,-0.8224181905632236,0.43936789354206485,0.05460795964675023,-15.060408700184178,2.949579536166945e-51,-0.9294478247400707,-0.7153885563863766,True,2132,E-dist
+approval_rate,0.50284471962431,1.6534180978647148,0.05796473721901896,8.67501076946693,4.135113454016432e-18,0.38923592230170445,0.6164535169469155,True,2132,E-dist
+max_e_distance,-0.19407296836060603,0.8235978054942833,0.0761129241436711,-2.549803079359729,0.01077837802669012,-0.34325155844023053,-0.04489437828098153,True,2132,E-dist

data/coefficients_LDVAE (vs ctrl).csv

@@ -0,0 +1,261 @@
+Feature,Coefficient,Odds_Ratio,HC_Std_Error,z_value,p_value,CI_Lower_95,CI_Upper_95,Significant,split_seed,X_features
+const,-1.0853817316199363,0.3377728227148319,0.03987545814309449,-27.219291819168713,3.839660890629482e-163,-1.163536193447436,-1.0072272697924367,True,432,LDVAE (vs ctrl)
+approval_rate,0.5595908518222618,1.7499563623460475,0.04432346888026038,12.625159220592447,1.5343080269424117e-36,0.4727184491470695,0.646463254497454,True,432,LDVAE (vs ctrl)
+ldvae_minusctrl_16,-0.47500487278816567,0.6218820261582596,103401.31670202976,-4.593799072762111e-06,0.9999963346786445,-202663.33169487107,202662.38168512547,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_18,-0.4718230302172032,0.6238639082094792,162142.59815929466,-2.909926420160527e-06,0.9999976782146363,-317794.1245749982,317793.1809289378,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_0,-0.37143420795688226,0.6897443840286038,66789.69551993374,-5.561250205819935e-06,0.999995562764322,-130905.76919167429,130905.02632325837,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_21,-0.3537984253461665,0.7020164618193427,44038.27303968195,-8.033885094162667e-06,0.9999935898871202,-86313.78289754323,86313.07530069254,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_42,0.33335768273043026,1.3956464078209492,70953.81654603581,4.698234696285058e-06,0.9999962513510728,-139066.59163820962,139067.2583535751,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_19,0.31844366634227306,1.3749861610022838,64868.51729929104,4.909063434778914e-06,0.9999960831340774,-127139.63919345755,127140.27608079024,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_29,0.282500002526782,1.3264417784483784,47674.69168799519,5.92557586686853e-06,0.999995272074502,-93440.3961825191,93440.96118252417,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_9,-0.2648243979209657,0.7673406847652273,94905.54572464104,-2.790399611518248e-06,0.9999977735832315,-186011.71637781366,186011.18672901782,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_32,-0.2617223589175221,0.7697247012426351,57009.22094869189,-4.590877660880007e-06,0.9999963370095939,-111736.28156848138,111735.75812376355,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_41,0.25762976426604645,1.2938596968412153,126898.60452783915,2.0302017128133773e-06,0.999998380133398,-248716.4369331919,248716.95219272043,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_34,0.23304815905335471,1.262442275888219,96796.74216189783,2.4076033330085527e-06,0.9999980790104721,-189717.89540997046,189718.36150628855,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_44,0.2328740607438014,1.2622225059534202,87604.20161486293,2.6582521894051707e-06,0.9999978790216194,-171700.84718545625,171701.31293357775,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_8,0.2299451847063066,1.2585310212911245,86713.34366574013,2.651785469058742e-06,0.9999978841813156,-169954.8006187104,169955.2605090798,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_46,0.20510392720179482,1.2276526448377072,152104.59430657278,1.3484400529572422e-06,0.9999989241005006,-298119.3216200316,298119.73182788596,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_48,0.1855883404200791,1.203926550454745,91364.75561161299,2.0312902845053935e-06,0.9999983792648435,-179071.44486672484,179071.81604340568,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_40,0.16606353149523667,1.1806481076802597,415691.81796195114,3.994871304164969e-07,0.9999996812553864,-814740.8258098731,814741.1579369361,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_31,-0.16212287233669403,0.8503367152617626,188225.78600916825,-8.613212661988684e-07,0.9999993127650598,-368915.92366258526,368915.59941684065,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_25,0.15521423147074886,1.1679081369842808,115717.55301454687,1.3413196825138263e-06,0.9999989297817342,-226802.08107338476,226802.39150184768,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_14,-0.1452443810290176,0.8648109239009921,85025.1295226412,-1.7082523936684003e-06,0.9999986370117891,-166646.3368896111,166646.046400849,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_30,-0.14272508626882938,0.8669923842471566,40474.864564976306,-3.5262647028677692e-06,0.9999971864478363,-79329.41955157627,79329.13410140375,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_1,0.11765881986620416,1.124860265914818,47558.83848281628,2.473963276220803e-06,0.9999980260628979,-93213.49291405758,93213.72823169733,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_12,0.10873910860540721,1.114871452028753,72294.35171094009,1.5041162418910252e-06,0.999998799888873,-141694.2169000056,141694.4343782228,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_49,0.10413872774633172,1.1097543979638609,53161.60418401782,1.958908677508256e-06,0.9999984370170102,-104194.72542232103,104194.93369977653,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_37,-0.09626734765803882,0.908221172804833,384697.2548953837,-2.50241836750871e-07,0.999999800335902,-753992.8608137248,753992.6682790294,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_36,0.09402820465585326,1.0985907308536993,94717.4331418427,9.927233196347572e-07,0.9999992079213901,-185642.66363788754,185642.85169429684,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_23,0.09157191822668237,1.0958955887258666,61343.95465425236,1.4927618987527177e-06,0.999998808948328,-120231.85021967463,120232.03336351107,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_43,-0.09113124983092213,0.9128978853427954,123712.94891913988,-7.366346904436536e-07,0.9999994122505536,-242473.0154340074,242472.83317150775,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_5,-0.08887860512080359,0.9149566378835222,99011.39938917365,-8.976603266807476e-07,0.9999992837706845,-194058.86574029655,194058.68798308633,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_10,-0.08357390873253406,0.9198231011993422,113898.75204095754,-7.337561407387609e-07,0.9999994145473039,-223237.53545824348,223237.36831042604,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_6,-0.08171948830867944,0.9215304225010135,39742.70464737769,-2.056213562558115e-06,0.9999983593789448,-77894.35147656122,77894.1880375846,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_45,-0.08100826816973054,0.9221860666221645,154753.0697690249,-5.234679240330328e-07,0.9999995823330253,-303310.5242525712,303310.3622360349,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_3,0.07897988910748095,1.082182558194356,94830.23218260359,8.328555914046328e-07,0.9999993354773823,-185863.7607435851,185863.9187033633,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_15,-0.07472589885768408,0.9279978167324665,40621.71274322552,-1.839555592597363e-06,0.999998532246994,-79617.16869295263,79617.01924115492,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_27,-0.0710510089162436,0.9314143804777216,53356.82549436776,-1.3316198678975683e-06,0.9999989375210665,-104577.5273493583,104577.38524734047,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_17,0.06510721361729276,1.067273444497011,154218.1494872183,4.2217607871561764e-07,0.9999996631522249,-302261.9536501484,302262.08386457566,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_26,0.051899060784138716,1.0532694209580056,31868.209265300997,1.6285527797336223e-06,0.9999987006028807,-62460.49051271483,62460.59431083639,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_33,-0.051456764857259314,0.9498447157463173,88948.61174922319,-5.784999208569289e-07,0.9999995384238447,-174336.1269600786,174336.02404654888,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_28,0.03816802892561071,1.0389057844360012,48983.988738400374,7.791939755957312e-07,0.999999378293157,-96006.81557835141,96006.89191440927,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_13,-0.03506147009280394,0.9655460622272847,45021.927730137315,-7.787643013192009e-07,0.9999993786359874,-88241.39192710437,88241.3218041642,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_22,0.030147932966437804,1.0306069834253773,83954.35260838945,3.5909910599948047e-07,0.9999997134803675,-164547.47730988672,164547.53760575264,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_2,-0.02944106753318388,0.9709880986789935,95246.6792340996,-3.091033490083461e-07,0.9999997533712102,-186680.09038694183,186680.03150480674,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_47,0.02023845212875468,1.0204446382143761,51917.23649307502,3.898214445881415e-07,0.9999996889674879,-101755.89346482349,101755.93394172774,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_24,-0.018763378444535458,0.981411557899855,51836.64919462023,-3.6197128356210917e-07,0.9999997111887013,-101597.9842640713,101597.9467373144,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_35,-0.01856258851235412,0.9816086352449189,66466.23031308678,-2.792784911212162e-07,0.9999997771680038,-130271.43616438299,130271.39903920598,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_11,0.017207087981347142,1.0173559827086416,149506.39254614455,1.1509265716538671e-07,0.9999999081693458,-293027.1276418629,293027.1620560389,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_39,0.011260280739890263,1.011323916328295,50955.16360986852,2.2098409547073807e-07,0.999999823680202,-99870.27424140753,99870.296761969,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_20,-0.008461636563789504,0.9915740623215877,85519.66865031149,-9.894374823163776e-08,0.9999999210543109,-167615.47898604622,167615.46206277312,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_4,-0.003548932054279624,0.9964573579619365,113589.50182749605,-3.124348638899085e-08,0.9999999750713046,-222631.33615267096,222631.32905480685,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_38,0.0035180065477389316,1.0035242019958526,74247.5687631089,4.738211104209126e-08,0.9999999621945451,-145522.557197348,145522.56423336113,False,432,LDVAE (vs ctrl)
+ldvae_minusctrl_7,0.002385450889773501,1.0023882983414492,55564.06419409379,4.293154081459476e-08,0.9999999657455864,-108903.56226964452,108903.5670405463,False,432,LDVAE (vs ctrl)
+const,-1.0227919943801935,0.35958956528020847,0.041129180852288214,-24.867793940595604,1.660318475050613e-136,-1.1034037075643128,-0.9421802811960742,True,43,LDVAE (vs ctrl)
+approval_rate,0.5086710610451822,1.663079594472307,0.043543476584423674,11.681911986493597,1.5770766152933813e-31,0.42332741517804867,0.5940147069123158,True,43,LDVAE (vs ctrl)
+ldvae_minusctrl_44,0.4174075291134292,1.5180210246581032,83228.15042513043,5.015220535135124e-06,0.999995998432966,-163123.75992560852,163124.59474066674,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_34,0.4138136557755951,1.5125752409611724,95538.96138582556,4.331360209207693e-06,0.9999965440745618,-187252.50962292525,187253.33725023683,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_18,-0.3847772492810236,0.6806022239555436,154497.17980349725,-2.490513093963374e-06,0.9999980128580539,-302809.2929051129,302808.5233506143,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_16,-0.35353644666216405,0.7022003992609507,95049.31219625483,-3.719505575507933e-06,0.9999970322639274,-186293.58219640984,186292.8751235165,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_32,-0.2922927240225092,0.7465499708748118,54043.17618863045,-5.408503804482192e-06,0.9999956846383173,-105922.97123259235,105922.38664714429,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_46,0.2451780098073293,1.2778487625721984,146540.66338320955,1.673105635984322e-06,0.9999986650548445,-287214.1773236884,287214.667679708,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_15,-0.2441156793404622,0.7833970061720706,39220.12284578711,-6.224245658289268e-06,0.9999950337704866,-76870.27236265865,76869.78413129998,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_38,-0.2270471036967091,0.7968832452593828,70812.07150147349,-3.2063333112912056e-06,0.9999974417161541,-138789.33686066687,138788.8827664595,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_28,0.21985202313681554,1.2458923537035942,46900.90430734452,4.687586015316713e-06,0.999996259847491,-91923.86343273162,91924.30313677789,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_27,0.20254828592155,1.2245192107329819,51455.9149987996,3.936346014375125e-06,0.9999968592502891,-100851.53764091567,100851.94273748751,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_30,-0.1883730920431708,0.8283056153420058,37958.79764238209,-4.962567408427258e-06,0.9999960404440829,-74398.06464860485,74397.68790242077,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_9,-0.1697625822577283,0.843865141371761,90752.57737159624,-1.8706089366764434e-06,0.9999985074700102,-177871.95291509558,177871.61338993107,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_29,-0.14923800801457632,0.8613640789455689,44491.989585857955,-3.3542669007099767e-06,0.9999973236822272,-87202.84642682076,87202.54795080473,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_11,0.13388000682180975,1.1432556285374609,138793.27657867767,9.646000881456045e-07,0.9999992303604823,-272029.68951050803,272029.9572705217,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_13,0.133562144389016,1.1428922882712385,41808.135812400425,3.194644817179365e-06,0.9999974510422232,-81942.30689091967,81942.57401520845,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_37,0.12782988943163337,1.1363596794634214,369014.15661608614,3.464091746610812e-07,0.9999997236054678,-723254.3289230623,723254.5845828411,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_12,-0.1260483733387936,0.881572201161211,67021.53718727463,-1.8807144483508859e-06,0.9999984994069784,-131359.92512394354,131359.67302719684,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_41,-0.12577629706111415,0.8818120886765799,120994.6414005995,-1.039519565537478e-06,0.999999170583388,-237145.26524381104,237145.0136912169,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_4,-0.11631203342472608,0.8901974086099017,105355.35460663983,-1.1039973607321116e-06,0.9999991191375507,-206492.81691949358,206492.5842954267,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_36,0.11349263279033954,1.1201836362342745,93749.01813511096,1.2106007619917053e-06,0.9999990340803427,-183744.5856381771,183744.81262344265,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_48,-0.10621425202182701,0.8992319651686811,82267.62196238787,-1.2910820744324827e-06,0.999998969865546,-161241.6823542886,161241.4699257846,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_35,-0.105601148561831,0.8997834564411934,62797.892654561045,-1.68160338027141e-06,0.9999986582746255,-123081.71350910062,123081.5023068035,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_49,-0.09567770600483448,0.9087568557536102,50252.87090032894,-1.9039251746353102e-06,0.9999984808874982,-98493.91276209166,98493.72140667964,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_33,0.0795584569082235,1.0828088553372623,82042.68169703394,9.6972033656842e-07,0.9999992262751152,-160800.6217628131,160800.7808797269,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_23,-0.07914101254047626,0.9239096324144603,58920.56801473285,-1.3431814255539316e-06,0.9999989282962782,-115482.2703985316,115482.11211650653,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_39,0.07758553983865192,1.0806746692418319,47773.412897620234,1.6240317601951511e-06,0.9999987042101323,-93634.09111235713,93634.2462834368,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_31,0.07192245594018781,1.0745720141564474,181044.0215529027,3.972650150127792e-07,0.9999996830283779,-354839.6899375267,354839.83378243854,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_42,-0.07169418766183117,0.9308155071568045,67640.11898000826,-1.0599358597080695e-06,0.9999991542935421,-132572.268805008,132572.12541663265,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_21,0.07054427282503827,1.0730920771968373,42048.97204154543,1.6776693792975193e-06,0.9999986614135041,-82414.40024408788,82414.54133263353,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_5,0.06958030610500962,1.0720581505623896,94419.67873483957,7.369258933872589e-07,0.9999994120182072,-185059.1001718219,185059.23933243408,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_26,0.06418350384028437,1.06628804876149,30787.10496320912,2.0847528183304103e-06,0.9999983366079132,-60341.55273264038,60341.68109964806,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_24,0.06417789401830112,1.0662820670921318,46849.991221364544,1.369859253869715e-06,0.9999989070104509,-91824.23129199819,91824.35964778623,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_7,0.06311248648159101,1.0651466470915065,53032.713225313084,1.1900670858278235e-06,0.9999990504638459,-103942.14481156817,103942.27103654115,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_19,0.056491839430679744,1.0581179799198692,64042.46308572668,8.820997305344153e-07,0.999999296186244,-125520.86463742076,125520.97762109964,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_40,-0.05646241472849348,0.9451020057430919,383997.834207364,-1.4703836766434213e-07,0.9999998826803566,-752621.9816502309,752621.8687254016,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_25,-0.05578261069726651,0.9457447083276695,107676.13904920708,-5.180591651022547e-07,0.9999995866485906,-211041.4103133835,211041.2987481621,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_43,-0.05264146436809328,0.9487201014727287,117526.88167205482,-4.47909989775643e-07,0.9999996426195346,-230348.5079339924,230348.40265106366,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_45,-0.04778452599719804,0.9533391847579477,149798.91396949478,-3.1899113772566426e-07,0.9999997454818962,-293600.5240879498,293600.42851889774,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_14,0.04735393540973616,1.0484930422294043,80689.2467506595,5.868679820009488e-07,0.9999995317470979,-158147.9702170228,158148.0649248936,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_1,-0.04423292420294247,0.9567310856923732,45883.42618260172,-9.640283623744493e-07,0.9999992308166535,-89929.9070381257,89929.81857227729,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_0,0.04244133650636493,1.04335484773787,62512.53417052022,6.789252278686135e-07,0.9999994582960428,-122522.27311521259,122522.35799788561,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_22,0.04048214661616207,1.0413127185809006,80334.19779143795,5.039217136550117e-07,0.9999995979286448,-157452.09391598892,157452.17488028214,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_10,0.029340025188721107,1.029774684283445,108424.9606580781,2.7060212898066806e-07,0.9999997840907392,-212508.98857498018,212509.04725503054,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_20,0.020140411557773824,1.0203445981434642,81146.85052613274,2.481970825384992e-07,0.9999998019673798,-159044.88434966374,159044.92463048687,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_8,0.018452656813324492,1.0186239591237478,81298.84106090323,2.2697318402732325e-07,0.9999998189016007,-159342.78201155964,159342.81891687325,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_47,0.015609486464259473,1.0157319508705345,49462.174510431774,3.155843150601349e-07,0.9999997482001474,-96944.06502799489,96944.09624696782,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_2,0.012623724157696713,1.0127037397070797,92135.7417449976,1.3701223779839057e-07,0.9999998906800508,-180582.72288535474,180582.74813280304,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_17,-0.010284470910040448,0.9897682334274249,146782.64428006753,-7.006598743661574e-08,0.9999999440954304,-287688.7066289575,287688.68606001564,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_3,-0.006300381422460513,0.9937194243640746,88347.78828841359,-7.131340291046968e-08,0.9999999431001368,-173158.48945944163,173158.4768586788,False,43,LDVAE (vs ctrl)
+ldvae_minusctrl_6,0.0022972619212538914,1.0022999026491821,37320.40176723601,6.155512300166829e-08,0.9999999508861177,-73146.64105508565,73146.64564960949,False,43,LDVAE (vs ctrl)
+const,-1.071602534141101,0.34245927476644894,0.04224893815716062,-25.364011046973,6.295807687489017e-142,-1.1544089313141959,-0.9887961369680063,True,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_38,-0.45023378199685493,0.63747910306235,67267.0052584108,-6.69323363314973e-06,0.9999946595722223,-131841.3578881336,131840.4574205696,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_40,-0.4393345908788003,0.644465111403522,342784.4940329924,-1.2816641316235123e-06,0.9999989773799772,-671845.7020980411,671844.8234288592,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_16,-0.42263062791601197,0.6553206455652654,89917.67729607369,-4.700195118746316e-06,0.999996249786882,-176235.83170442723,176234.98644317142,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_19,0.37917462956759307,1.4610781609140444,57933.02547399854,6.5450514014286025e-06,0.9999947778045372,-113546.26426984907,113547.02261910819,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_46,0.3211438809476524,1.3787039358524846,133520.57108559477,2.4052015231554077e-06,0.9999980809268391,-261695.1893791049,261695.8316668668,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_45,0.303336959405673,1.354370755527028,138686.89023270068,2.1872071606530973e-06,0.9999982548611752,-271821.00664699374,271821.6133209125,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_18,-0.3021934955021827,0.7391950201390874,139560.88881999953,-2.1653165013296863e-06,0.9999982723273944,-273534.61793109326,273534.01354410226,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_11,0.297062831321336,1.3458998614581796,130152.46168501404,2.2824219186899965e-06,0.9999981788907898,-255093.8403390255,255094.43446468815,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_28,0.2947957290903764,1.3428520250633917,42970.843900941174,6.86036629324656e-06,0.9999945262196532,-84221.01163540826,84221.60122686643,False,5235,LDVAE (vs ctrl)
+approval_rate,0.2851892558310349,1.330013717155242,0.042255891131592054,6.74910049684923,1.487645262082665e-11,0.202369231078469,0.3680092805836008,True,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_27,0.2641790115132205,1.3023613131043943,48510.13034244632,5.4458524363531565e-06,0.9999956548384207,-95077.84417752695,95078.37253554998,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_8,0.23740012673654812,1.2679483563265916,76763.19572765882,3.0926295405782544e-06,0.9999975324386373,-150452.86156428352,150453.33636453698,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_14,0.23352313871478428,1.2630420527226174,76606.76448608459,3.048335747911702e-06,0.9999975677799706,-150146.26584172915,150146.73288800658,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_30,-0.21700145631559692,0.8049287970737863,34456.22069877839,-6.297889086927357e-06,0.9999949750115319,-67533.16861442549,67532.73461151286,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_41,0.2164236289899965,1.241628257328758,110502.31364282587,1.9585438698554107e-06,0.9999984373080846,-216580.3385246588,216580.77137191678,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_31,-0.2133435912513415,0.8078785095359752,170342.43238960905,-1.2524395023512387e-06,0.9999990006978577,-333865.24586617417,333864.81917899166,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_9,-0.19652918640044587,0.8215773520597272,79315.71335983388,-2.4778089747342526e-06,0.9999980229944745,-155456.1381225632,155455.7450641904,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_23,0.19562680164301863,1.2160729841986013,54303.37805683617,3.602479415521213e-06,0.9999971256372937,-106432.46960345992,106432.86085706319,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_7,-0.19512408224759234,0.8227325652163354,49687.625825053416,-3.927015610176471e-06,0.9999968666948746,-97386.15221848924,97385.76197032473,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_37,0.16770218519492297,1.1825843670659726,345917.64026397874,4.848037962647556e-07,0.9999996131825359,-677985.9488322956,677986.284236666,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_22,0.15182374242263572,1.1639550624514405,71977.41509661953,2.1093247405291472e-06,0.9999983170023559,-141072.98946592142,141073.29311340628,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_0,-0.1513871320205797,0.8595148885071227,59395.32771207174,-2.548805400223614e-06,0.9999979663475227,-116412.85455274644,116412.5517784824,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_21,-0.1493022435995189,0.8613087504971559,38887.6574717206,-3.839322121886427e-06,0.999996936664155,-76218.55738994593,76218.25878545872,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_43,0.1445572602533667,1.1555278588874254,109483.59712210779,1.320355414447527e-06,0.9999989465088001,-214583.7626999641,214584.05181448464,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_26,0.14056617847808003,1.150925243525613,27882.618038004537,5.041355093932918e-06,0.999995977580605,-54648.78658299727,54649.067715354235,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_15,-0.1346268160775464,0.874042029266202,34518.76083723653,-3.900105705194376e-06,0.9999968881658723,-67655.66265875135,67655.3934051192,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_48,0.12885201865810048,1.137521779710718,80564.6521224832,1.599361696022786e-06,0.9999987238939956,-157903.68773504684,157903.94543908414,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_33,-0.1287681428171988,0.879177785600649,77728.08834559245,-1.656648781128818e-06,0.9999986781855149,-152344.38251265153,152344.1249763659,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_35,-0.12529874532640814,0.8822333001363388,57968.30459762523,-2.1615043978971436e-06,0.9999982753690128,-113615.91455493841,113615.66395744774,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_12,0.12396985174950215,1.1319817432155779,61669.599124727625,2.0102263272179117e-06,0.9999983960714498,-120870.06925563724,120870.31719534073,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_25,0.12386133418018805,1.131858909973199,98686.37533733224,1.2551006535279277e-06,0.9999989985745663,-193421.61756463884,193421.86528730718,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_47,0.1154849064092957,1.1224175731089783,45204.42813809643,2.5547255250414237e-06,0.9999979616239465,-88598.93560749161,88599.16657730442,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_44,0.11327847130248292,1.1199437617269237,78307.39069523446,1.4465872288268787e-06,0.9999988457903842,-153479.55220749517,153479.7787644378,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_2,-0.11047037756362854,0.8954128541069295,84187.83674127933,-1.312189288140507e-06,0.9999989530244261,-165005.23841962297,165005.0174788678,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_36,0.10753957940756936,1.113534932927308,83694.94789393916,1.2848992933700952e-06,0.9999989747986916,-164038.97602049776,164039.1910996566,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_32,-0.10537234101244954,0.8999893572437664,49507.33150900506,-2.1284189189894633e-06,0.9999983017674057,-97032.69210067594,97032.4813559939,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_3,0.10489441680986868,1.1105933441769287,79931.22216556521,1.3123084317739576e-06,0.9999989529293632,-156662.21179036066,156662.42157919428,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_34,0.09653279624503257,1.1013457005549614,88862.19888831247,1.0863201389643867e-06,0.999999133241933,-174166.61287533143,174166.80594092392,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_5,-0.09575516761905783,0.9086864647069642,88349.62186796275,-1.0838209105429174e-06,0.9999991352360288,-173162.172664107,173161.98115377175,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_6,0.09456604239117747,1.099181753327277,34367.062612793154,2.7516475136858285e-06,0.9999978045029321,-67358.1104094652,67358.29954154998,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_4,-0.09085830011457985,0.913147094570896,98013.27683602065,-9.269999233531258e-07,0.9999992603610733,-192102.58346365453,192102.40174705433,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_39,-0.05641449416381619,0.945147296650059,44526.926678955235,-1.2669748031471344e-06,0.9999989891003657,-87271.2290475021,87271.11621851378,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_24,-0.04915048203382137,0.9520378543259966,45249.607837333766,-1.0862079116908753e-06,0.9999991333314774,-88687.65082621758,88687.5525252535,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_49,0.04822435659389446,1.0494060700865526,45688.752621015556,1.0554973341888216e-06,0.9999991578349731,-89548.26141139389,89548.35786010708,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_1,0.045609843620001166,1.0466659678786865,42514.32239342242,1.072811256355756e-06,0.9999991440204619,-83326.49510838903,83326.58632807629,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_29,0.023015261784519982,1.0232821565398218,41061.16894382517,5.605116068664929e-07,0.9999995527764427,-80478.38927775012,80478.43530827369,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_13,0.01854690020638827,1.0187199622256697,38980.23934251784,4.7580262510492515e-07,0.9999996203644315,-76399.84667318604,76399.88376698644,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_10,0.011051438424546353,1.0111127311530144,101561.93306041732,1.0881477037239983e-07,0.9999999131783748,-199057.71994724733,199057.7420501242,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_20,-0.008379772798765034,0.9916552396303248,74510.07685981826,-1.1246495980041153e-07,0.9999999102659449,-146037.07551032788,146037.05875078228,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_17,-0.0015682364834117006,0.998432992556863,136029.6714371492,-1.1528635384055048e-08,0.9999999908014798,-266613.2584138658,266613.2552773928,False,5235,LDVAE (vs ctrl)
+ldvae_minusctrl_42,-0.00035781561232259534,0.999642248396049,62699.48627947048,-5.706834833186726e-09,0.9999999954466046,-122888.73531474103,122888.7345991098,False,5235,LDVAE (vs ctrl)
+const,-1.3339677488676625,0.2634299610319781,0.04876542258225801,-27.354787023889973,9.471989159809526e-165,-1.4295462208197645,-1.2383892769155604,True,332,LDVAE (vs ctrl)
+approval_rate,0.7293425744636697,2.0737168450280077,0.04807055327904571,15.172335758856248,5.392319804608311e-52,0.6351260213198263,0.823559127607513,True,332,LDVAE (vs ctrl)
+ldvae_minusctrl_34,0.5964614515785163,1.8156825390127758,107835.24028258324,5.531229401589717e-06,0.9999955867174583,-211352.5907566344,211353.78367953756,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_42,0.4890555983674445,1.6307753855501919,75439.12493629857,6.4827846131620315e-06,0.9999948274862461,-147857.47884476432,147858.45695596104,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_19,-0.4121874930059956,0.6622001065234843,71554.10643888346,-5.760500878563237e-06,0.9999954037852865,-140243.88375365018,140243.05937866418,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_28,0.36851236581023994,1.4455825163172846,52473.03800283357,7.022889846597792e-06,0.9999943965446192,-102844.89613258957,102845.63315732118,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_18,-0.35044340660446865,0.7043756956295613,172679.68337695312,-2.0294420267117594e-06,0.9999983807395398,-338446.3107240146,338445.60983720137,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_40,0.34448168846285526,1.411258258632521,418916.813641635,8.223152598442713e-07,0.99999934388735,-821061.5227741938,821062.2117375707,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_17,-0.3313028295065381,0.7179877082520701,166640.69352791685,-1.988126804399286e-06,0.9999984137043179,-326610.08897632343,326609.42637066444,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_44,0.3072793216300314,1.3597207144401693,95376.17481349436,3.221761852275038e-06,0.9999974294059595,-186933.56033832353,186934.17489696678,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_0,-0.30373220890997304,0.7380584854754323,70744.82221421525,-4.293348960440839e-06,0.9999965744031504,-138657.60736475996,138656.99990034214,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_38,-0.2993237034774905,0.7413194029229776,81358.53611662866,-3.679069434686061e-06,0.9999970645273,-159460.0999471969,159459.50129978993,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_48,-0.26007408973828067,0.7709944609095836,94812.55701034454,-2.7430342344833633e-06,0.9999978113753345,-185829.45709651566,185828.93694833617,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_20,0.2404671680615701,1.2718431760668574,90198.74801275728,2.665970131066116e-06,0.9999978728635929,-176786.05708843996,176786.5380227761,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_7,0.23239784462824134,1.261621558356485,59723.85070598033,3.891206643261042e-06,0.9999968952662964,-117056.36400392391,117056.82879961315,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_11,0.23175027711639615,1.2608048376924743,157483.9671321916,1.4715801318483779e-06,0.9999988258489328,-308662.67197130807,308663.1354718623,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_16,-0.21581273014777924,0.8058862059338401,110370.48770647199,-1.9553481608392334e-06,0.9999984398578915,-216322.39667353604,216321.96504807577,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_22,-0.1805368611552114,0.8348219076298706,89963.8759312704,-2.006770598602665e-06,0.9999983988287223,-176326.13727178096,176325.77619805865,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_4,-0.17858345013583002,0.8364542517438854,120522.53141467679,-1.4817432727278643e-06,0.9999988177399196,-236219.99948181392,236219.64231491362,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_32,-0.17612611341505213,0.83851222902793,61346.83747609018,-2.870989290747008e-06,0.9999977092819707,-120237.76814468222,120237.4158924554,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_27,-0.16370348000277357,0.8489937281783118,57910.81283849826,-2.8268206225892565e-06,0.9999977445234691,-113503.27118237638,113502.94377541637,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_37,-0.13394362284965894,0.8746393728888102,414042.3860632851,-3.235022001568363e-07,0.9999997418825891,-811508.2987006905,811508.0308134449,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_46,0.120610955679078,1.1281859126554459,160099.73898637347,7.533488589218969e-07,0.9999993989145766,-313789.60173659946,313789.84295851085,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_14,0.12023454203103497,1.1277613279951362,90934.48539843096,1.3222106168438225e-06,0.9999989450285627,-178228.1960990661,178228.43656815015,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_39,0.11890198596503289,1.1262595236379969,53957.485472659086,2.203623555165149e-06,0.9999982417627875,-105754.60932076903,105754.84712474095,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_6,-0.10489018356992985,0.9004233984402379,41723.25258837155,-2.513950304995234e-06,0.9999979941578651,-81776.1772812594,81775.96750089225,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_8,-0.10274559386980647,0.9023565093102061,93183.67885465031,-1.102613624324395e-06,0.9999991202416126,-182636.75724765507,182636.55175646732,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_1,-0.0985030992234653,0.9061928841156681,52550.84603703287,-1.8744341271698962e-06,0.9999985044179497,-102997.86409279308,102997.66708659462,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_33,-0.0950101069136899,0.9093637435609168,96541.3547236544,-9.841389442446956e-07,0.9999992147707307,-189217.67328717536,189217.48326696153,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_30,-0.09406031756188887,0.910227857859785,42993.589518239554,-2.187775401306858e-06,0.9999982544077848,-84265.98108216586,84265.79296153075,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_9,-0.08834216100815166,0.9154475926583724,97524.53802422747,-9.058454702569862e-07,0.9999992772398848,-191144.6704785539,191144.49379423188,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_25,-0.08725341722501102,0.916444823299494,122096.52162772094,-7.146265598871976e-07,0.9999994298105012,-239304.87228136606,239304.69777453158,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_5,-0.08438021383243481,0.9190817420628298,104448.93256328496,-8.078609494770026e-07,0.9999993554202211,-204716.23042790525,204716.06166747757,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_41,-0.08232484445023569,0.9209727372162583,134378.36218807605,-6.126346765189308e-07,0.9999995111882501,-263376.8325149525,263376.66786526365,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_43,0.0779316020860053,1.0810487146642944,132491.6748206793,5.881999921238956e-07,0.9999995306843076,-259678.83296832166,259678.9888315258,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_12,0.06442769866314557,1.0665484625772352,74884.1474777852,8.603649882274271e-07,0.9999993135280593,-146770.16764174626,146770.2964971436,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_23,-0.06067492441263475,0.941129128159016,67346.0964357346,-9.009419643280165e-07,0.9999992811523165,-131995.9841883255,131995.8628384767,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_47,0.05986647787694843,1.0616947773402043,54601.15723273046,1.0964324001737769e-06,0.999999125173516,-107016.2418238825,107016.36155683827,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_21,0.056367850724080334,1.0579867933731026,48431.206913108304,1.1638745824610848e-06,0.9999990713624399,-94923.36490964885,94923.47764535029,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_29,-0.05413215710744228,0.9473069048884288,49293.66933956248,-1.0981563724653885e-06,0.9999991237979851,-96613.87070352588,96613.76243921167,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_13,-0.05314414726171327,0.9482433159528871,47830.880512361735,-1.1110844436154241e-06,0.9999991134828767,-93746.85629721498,93746.75000892047,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_15,0.05028209053049338,1.0515676918287107,42732.04250719977,1.1766835278707198e-06,0.9999990611423801,-83753.21401785569,83753.31458203674,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_45,-0.033226505205673745,0.9673194318863145,164741.88835770247,-2.0168826238976546e-07,0.9999998390760494,-322888.2011527205,322888.13469971006,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_3,-0.026677620540689923,0.9736750837805231,99276.87179676132,-2.6871939111159844e-07,0.9999997855929467,-194579.11989707296,194579.06654183188,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_2,0.02324470764540229,1.0235169713327656,104151.06588569214,2.231826188981476e-07,0.9999998219260341,-204132.31484270722,204132.3613321225,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_31,-0.022067072972540933,0.9781746237711824,203448.38370722963,-1.0846521643689406e-07,0.9999999134572785,-398751.5268461286,398751.4827119826,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_26,0.014385514974806229,1.014489484448593,34733.83965571176,4.1416425933320687e-07,0.9999996695447319,-68077.06038446918,68077.08915549914,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_49,0.012300387621001007,1.0123763485188029,56582.32520809777,2.1738922138252174e-07,0.9999998265484966,-110899.30726901682,110899.33186979206,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_24,-0.005534244111303829,0.9944810416063404,53368.77662833861,-1.036981632508542e-07,0.9999999172608366,-104600.88562475075,104600.87455626254,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_10,0.003465037813479912,1.003471047996837,122851.93757017772,2.8204991162638767e-08,0.999999977495673,-240785.36960347366,240785.3765335493,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_36,-0.0009385468780807017,0.9990618934192831,104666.79885300067,-8.966997064645536e-09,0.9999999928453714,-205143.15706752642,205143.15519043268,False,332,LDVAE (vs ctrl)
+ldvae_minusctrl_35,-0.0008786113100583839,0.9991217745558417,71349.08290292624,-1.2314262136400206e-08,0.9999999901746404,-139841.63369830928,139841.63194108664,False,332,LDVAE (vs ctrl)
+const,-0.8971996459555441,0.4077097943768504,0.040902665763689575,-21.934991991451398,1.2045918698298732e-106,-0.9773673977240552,-0.817031894187033,True,2132,LDVAE (vs ctrl)
+approval_rate,0.7523062936931597,2.121888074881759,0.04677958746799762,16.081935186106975,3.4154112344311574e-58,0.6606199870442431,0.8439926003420763,True,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_20,0.462443208080092,1.5879489390861048,88772.85752037339,5.209286047528223e-06,0.9999958435910898,-173991.14110142944,173992.06598784562,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_38,-0.2967128835852599,0.7432573831244217,80191.10709848849,-3.70007216911029e-06,0.9999970477695425,-157171.97850631527,157171.38508054812,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_0,-0.2568127453314766,0.7735130441336224,71210.09204449241,-3.606409400103271e-06,0.9999971225016198,-139569.47255573267,139568.95893024202,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_12,0.24755937724524887,1.2808954161670314,77956.61931452963,3.1756043222760497e-06,0.99999746623434,-152791.91865360038,152792.4137723549,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_42,0.2182255204416085,1.2438675535501968,76983.0340930592,2.834722260723207e-06,0.999997738218874,-150883.75601749468,150884.1924685356,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_46,-0.20542771719176917,0.814298952254937,162139.57655816307,-1.2669807184187242e-06,0.9999989890956459,-317787.93595029163,317787.52509485726,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_47,0.17459708880171237,1.1907663468507093,55790.098216565915,3.1295354262321186e-06,0.999997502992001,-109346.40860133269,109346.75779551029,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_43,0.16016609218182384,1.1737057981602586,133899.56268425085,1.1961659095146727e-06,0.9999990455976886,-262438.16024070285,262438.4805728872,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_7,-0.14980440192511088,0.8608763457141059,62021.19854136068,-2.4153741857344043e-06,0.9999980728102287,-121559.46522347699,121559.16561467314,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_11,-0.138581771498508,0.8705920587411636,160942.00985041098,-8.610664898948019e-07,0.9999993129683419,-315440.68148806767,315440.4043245246,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_33,-0.13677922822879643,0.872162753794924,94123.45242166326,-1.4531896643149015e-06,0.999998840522403,-184478.71362625755,184478.4400678011,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_49,-0.13571638416728327,0.8730902195869141,56593.54138823786,-2.398089620090287e-06,0.9999980866013167,-110921.4385949073,110921.16716213898,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_29,0.12573470511576687,1.1339812889391427,49173.171090590724,2.5569777650525812e-06,0.999997959826919,-96377.51860847887,96377.7700778891,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_5,0.12392043166891167,1.131925801968923,108871.25238970053,1.1382291371586612e-06,0.9999990918245448,-213383.60971515166,213383.85755601502,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_9,0.12041782837943711,1.1279680501949134,97701.53592652081,1.2325070147310757e-06,0.9999990166016819,-191491.37123239858,191491.61206805534,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_22,0.11101748550296674,1.1174144452372359,89524.65599632854,1.2400772085348157e-06,0.9999990105615411,-175464.99046365623,175465.21249862722,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_18,-0.10895195263321046,0.8967735040686061,173772.73782866017,-6.269795480844471e-07,0.9999994997426986,-340588.41659104766,340588.19868714234,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_3,-0.09639623303603424,0.9081041239187796,101327.60490752273,-9.513323948001224e-07,0.99999924094657,-198598.55265468164,198598.35986221556,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_34,-0.09587065165763982,0.908581531983359,105202.91445014019,-9.112927351749053e-07,0.9999992728935962,-206194.01926157484,206193.82752027153,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_23,-0.08764148637225919,0.9160892483367148,68966.69970270661,-1.2707797640028247e-06,0.9999989860644461,-135172.33519138058,135172.15990840783,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_44,0.0781274246675724,1.081260429142961,97258.51367243762,8.032965106859654e-07,0.9999993590621163,-190623.1058604495,190623.26211529883,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_37,-0.07785230525371878,0.9251010490187993,420467.780200331,-1.8515641131081723e-07,0.9999998522665581,-824101.7837044577,824101.6279998472,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_10,0.07693028451850574,1.0799667833637858,123106.6736020739,6.249075071849698e-07,0.9999995013959481,-241284.56958630812,241284.72344687718,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_36,0.07512061978457032,1.078014172880158,100800.12799705367,7.452432975756346e-07,0.9999994053818788,-197564.545390633,197564.69563187257,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_19,-0.07452662752500852,0.9281827585203131,72097.57910541611,-1.0336911231934823e-06,0.9999991752338122,-141308.7329457706,141308.58389251557,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_2,-0.0663930968123176,0.9357629465513368,104790.54675560434,-6.335790666992279e-07,0.9999994944770446,-205385.76395434194,205385.6311681483,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_24,0.06546868956182209,1.0676593079094008,54476.715108816024,1.2017738116376848e-06,0.9999990411232301,-106772.33414063886,106772.46507801798,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_25,-0.061759110358838465,0.9401093221142888,118900.42625687482,-5.19418746451025e-07,0.9999995855638016,-233040.61496904562,233040.4914508249,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_35,0.06034612182436406,1.0622041349595428,70491.9795176569,8.560707507050288e-07,0.9999993169543651,-138161.6807074209,138161.80139966452,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_21,0.05892329433748923,1.060693876393136,48164.15340803761,1.2233848239436956e-06,0.9999990238801371,-94399.94710232149,94400.06494891015,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_48,0.05658657352149495,1.0582182245128873,97280.44166001392,5.816849980930366e-07,0.9999995358825208,-190666.10546720366,190666.21864035068,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_1,-0.05237912611293454,0.9489690196977418,51980.97082741909,-1.007659635423843e-06,0.9999991960039344,-101880.88308229475,101880.77832404253,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_14,0.04756890286076396,1.0487184583338074,91946.55373778094,5.173538422812888e-07,0.9999995872113567,-180211.88625972444,180211.98139753018,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_17,-0.0466882614330797,0.9543848697927827,170510.3704694107,-2.7381479088074295e-07,0.9999997815274059,-334194.2317988884,334194.13842236553,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_45,0.045757096950352155,1.046820104276492,168585.14428450493,2.714183218488831e-07,0.9999997834395115,-330420.7653690212,330420.85688321514,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_8,-0.042395979049196036,0.9584901633936558,90413.51275387136,-4.68911977401085e-07,0.9999996258623729,-177207.27110931976,177207.18631736166,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_30,-0.04153677310787553,0.9593140577335111,44580.13348919074,-9.317328113866431e-07,0.999999256584775,-87375.49760157488,87375.41452802868,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_32,-0.03998454741461175,0.9608042859478823,62116.720210229374,-6.437002352874887e-07,0.9999994864015205,-121746.57443434828,121746.49446525345,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_13,-0.038293971972511526,0.9624299718635229,47993.78446885148,-7.978944022921292e-07,0.9999993633723753,-94066.12733469869,94066.05074675474,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_41,0.03584676270432843,1.0364970043230484,136486.10661978778,2.626403785125728e-07,0.9999997904432969,-267507.8175181152,267507.88921164064,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_26,-0.03212170969165996,0.9683887126147956,34552.245748264395,-9.296562060158845e-07,0.9999992582416664,-67721.18937328512,67721.12512986573,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_31,0.031088036958481932,1.0315763167303877,212051.5459968153,1.466060377553146e-07,0.999999883025306,-415613.3619317597,415613.4241078336,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_15,-0.0204156947206855,0.9797912945714998,42742.41330506243,-4.776448764128967e-07,0.9999996188945276,-83773.61110594269,83773.57027455326,False,2132,LDVAE (vs ctrl)
+ldvae_minusctrl_6,-0.018660594937219343,0.9815124360061105,42341.91985341154,-4.407120650604093e-07,0.9999996483626475,-82988.65660956306,82988.61928837317,False,2132,LDVAE (vs ctrl)
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data/coefficients_LDVAE.csv

@@ -0,0 +1,261 @@
+Feature,Coefficient,Odds_Ratio,HC_Std_Error,z_value,p_value,CI_Lower_95,CI_Upper_95,Significant,split_seed,X_features
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+20,0.2386474959394395,1.2695309428867987,141626.95869230997,1.6850428629051506e-06,0.9999986555303154,-277583.49962937355,277583.9769243654,False,332,LDVAE
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+42,0.09935306992907467,1.1044561809926159,123604.41770244352,8.037986972945431e-07,0.9999993586614294,-242260.10767376446,242260.30637990433,False,332,LDVAE
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data/coefficients_approval rate.csv

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data/coefficients_mrVI (vs ctrl).csv

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+X19,-0.19391055409316107,0.8237315803917139,0.10656909715372871,-1.819575836449473,0.06882362423161646,-0.40278214637941934,0.014961038193097187,False,432,mrVI (vs ctrl)
+X12,0.1824843435986212,1.200195360066189,0.11435634457253022,1.5957518079189823,0.11054421672750983,-0.04164997316719052,0.40661866036443295,False,432,mrVI (vs ctrl)
+X23,-0.16581401407224367,0.8472037875200149,0.1007903715042285,-1.6451374431662573,0.09994147052956315,-0.3633595122089437,0.03173148406445633,False,432,mrVI (vs ctrl)
+X9,-0.14290711123285443,0.8668345843517999,0.11390297175859536,-1.2546390056945145,0.20960983695342628,-0.36615283361178425,0.08033861114607538,False,432,mrVI (vs ctrl)
+approval_rate,0.13818392500486743,1.1481867111011332,0.04132854804336906,3.343546568823588,0.0008271481004837018,0.05718145930653075,0.21918639070320411,True,432,mrVI (vs ctrl)
+X2,-0.13130563941477383,0.8769497030325228,0.12021936816027604,-1.0922170148134336,0.27473772548547903,-0.3669312712530761,0.10431999242352849,False,432,mrVI (vs ctrl)
+X27,-0.12555838840282157,0.8820042641032739,0.10829477251206193,-1.1594131968727928,0.24628780007486129,-0.33781224224042117,0.08669546543477805,False,432,mrVI (vs ctrl)
+X15,-0.1148884030051401,0.8914656232405054,0.10063659841218263,-1.1416165174282382,0.25361345523334244,-0.3121325114196388,0.08235570540935865,False,432,mrVI (vs ctrl)
+X25,-0.11392341836559557,0.8923262890714804,0.11668651998839438,-0.9763203014103632,0.3289057625626626,-0.34262479502416165,0.11477795829297054,False,432,mrVI (vs ctrl)
+X29,0.10205340485079824,1.1074426129562176,0.11580782921998642,0.8812306174648993,0.378193010700112,-0.12492576954814046,0.32903257924973695,False,432,mrVI (vs ctrl)
+X14,0.09805388678706814,1.1030222218306656,0.1364437327080489,0.7186397267280557,0.4723629292506476,-0.16937091523691752,0.36547868881105383,False,432,mrVI (vs ctrl)
+X22,0.0905712634254482,1.0947995240260173,0.09679374111603099,0.9357140490817105,0.3494204351835647,-0.09914098309086637,0.28028350994176277,False,432,mrVI (vs ctrl)
+X13,0.057049873957843646,1.058708611067437,0.08654514289349052,0.6591920938654391,0.5097724232066319,-0.11257548915027038,0.22667523706595766,False,432,mrVI (vs ctrl)
+X16,0.05634449440462736,1.0579620829841525,0.12212738079010489,0.4613584115216901,0.6445414839609802,-0.18302077347018708,0.2957097622794418,False,432,mrVI (vs ctrl)
+X24,-0.055071335165138506,0.9464176326872884,0.13180704777479954,-0.41781783368087627,0.6760803109742688,-0.3134084017122959,0.20326573138201887,False,432,mrVI (vs ctrl)
+X5,-0.0435266227034363,0.957407064987315,0.08922879114631538,-0.4878091717286892,0.625685014299148,-0.21841183973426087,0.13135859432738828,False,432,mrVI (vs ctrl)
+X8,0.03830699303583548,1.0390501650855746,0.19209047497353304,0.19942161651228965,0.8419329525348543,-0.3381834196854819,0.4147974057571528,False,432,mrVI (vs ctrl)
+X21,0.035268638868075464,1.035897953878,0.09721429895380004,0.36279270897007104,0.7167597387581228,-0.15526788586368248,0.2258051635998334,False,432,mrVI (vs ctrl)
+X10,-0.02964472943748587,0.9707903655298002,0.10467631371174219,-0.28320379641111143,0.7770206183239974,-0.23480653434691678,0.17551707547194506,False,432,mrVI (vs ctrl)
+X18,0.009848799192510636,1.0098974582284423,0.13511071269725816,0.07289428792059433,0.9418902394317864,-0.25496333161965395,0.27466093000467523,False,432,mrVI (vs ctrl)
+X17,0.005757901742363324,1.0057745103201525,0.08844992811880872,0.0650978679669375,0.9480960779497982,-0.16760077180565838,0.17911657529038502,False,432,mrVI (vs ctrl)
+const,-0.6792284011410464,0.5070080483085834,0.0368396008119262,-18.43745280000856,6.576734808721749e-76,-0.7514326919372543,-0.6070241103448386,True,43,mrVI (vs ctrl)
+approval_rate,0.5657694564686028,1.7608021221852084,0.04026413854386091,14.05144818514603,7.547468073550727e-45,0.48685319505410435,0.6446857178831011,True,43,mrVI (vs ctrl)
+X26,0.40617696646697266,1.501068167685153,0.16985788987827877,2.3912752404850997,0.01678996059082683,0.07326161981557566,0.7390923131183696,True,43,mrVI (vs ctrl)
+X3,-0.3749994202811605,0.6872896772256308,0.1543349946655394,-2.429775703778814,0.015108169302932352,-0.6774904513797991,-0.07250838918252189,True,43,mrVI (vs ctrl)
+X18,0.27324177075957845,1.314217945888807,0.1919856111714743,1.4232408829614278,0.1546663378027211,-0.10304311268642186,0.6495266542055788,False,43,mrVI (vs ctrl)
+X12,0.2482093333822227,1.2817282126148544,0.13471022837275676,1.8425425922031882,0.06539582236805697,-0.015817862577546277,0.5122365293419917,False,43,mrVI (vs ctrl)
+X25,0.20718920399948496,1.2302153114195713,0.1463575376239482,1.4156373997753224,0.15688169534724844,-0.07966629860941946,0.4940447066083894,False,43,mrVI (vs ctrl)
+X30,0.20416049680262063,1.226494986183989,0.10202041602331358,2.001172949108207,0.0453737550597827,0.0042041557091329895,0.4041168378961083,True,43,mrVI (vs ctrl)
+X16,-0.20281527288043547,0.816429044082153,0.15831862159459326,-1.2810575966217344,0.20017343632777762,-0.5131140692878635,0.10748352352699256,False,43,mrVI (vs ctrl)
+X4,-0.19958578143904054,0.8190699567997238,0.15563764128702134,-1.2823747506618377,0.1997112171558464,-0.5046299530003665,0.10545839012228542,False,43,mrVI (vs ctrl)
+X2,-0.19848708051563227,0.8199703642662763,0.12460557105356813,-1.592923003661709,0.11117746506095434,-0.4427095120536725,0.045735351022407944,False,43,mrVI (vs ctrl)
+X1,0.196785794144911,1.2174832207379689,0.11148396955938478,1.7651487915496948,0.07753876232927881,-0.021718771045042856,0.4152903593348649,False,43,mrVI (vs ctrl)
+X7,0.17892081046238126,1.1959260355881842,0.15049011796084788,1.188920660617264,0.2344708891483196,-0.11603440077006491,0.47387602169482745,False,43,mrVI (vs ctrl)
+X21,0.16796415928525724,1.1828942141139553,0.13326709526282823,1.2603573219180604,0.20754049011827203,-0.09323454775415455,0.42916286632466905,False,43,mrVI (vs ctrl)
+X14,-0.16310422958046464,0.8495026404961917,0.16149487036000854,-1.009965389097923,0.31251187249151247,-0.47962835917404645,0.15341990001311714,False,43,mrVI (vs ctrl)
+X24,0.1563626947291429,1.169250207080372,0.15244856892846145,1.0256750576813758,0.3050447749900037,-0.14243100986531346,0.4551563993235993,False,43,mrVI (vs ctrl)
+X11,0.1277769959866997,1.136299575074869,0.11260935203748688,1.1346925781454067,0.2565041480960716,-0.09293327832916676,0.34848727030256615,False,43,mrVI (vs ctrl)
+X6,-0.11295061146626614,0.8931947726068388,0.16691869038169724,-0.6766804316998839,0.4986087347074828,-0.440105232960985,0.21420401002845277,False,43,mrVI (vs ctrl)
+X5,-0.10700452790318478,0.8985216045622599,0.12958359278867732,-0.8257567613338667,0.408942086361899,-0.36098370275629654,0.146974646949927,False,43,mrVI (vs ctrl)
+X8,-0.09905755497239847,0.9056905795271296,0.22865381924746153,-0.43322064463394344,0.664854482211954,-0.5472108056249545,0.3490956956801575,False,43,mrVI (vs ctrl)
+X23,-0.09063945856485435,0.913346950963843,0.11294089008318453,-0.8025389077250544,0.42224129138500177,-0.311999535509793,0.13072061838008425,False,43,mrVI (vs ctrl)
+X15,-0.08780326522101717,0.9159410564602382,0.12388270930708521,-0.7087612606483046,0.47847264163855163,-0.3306089137701491,0.1550023833281148,False,43,mrVI (vs ctrl)
+X29,-0.08043189494300104,0.9227177431883786,0.15577823974911342,-0.5163230440435042,0.6056288041569577,-0.3857516344263092,0.2248878445403071,False,43,mrVI (vs ctrl)
+X20,0.07536157344509965,1.0782739556377623,0.21516190303263888,0.3502551910115227,0.7261471902759982,-0.346348007343972,0.49707115423417125,False,43,mrVI (vs ctrl)
+X10,0.06763132203734087,1.069970761112472,0.12213789625620218,0.5537292200896783,0.5797641746178427,-0.1717545557723049,0.3070171998469866,False,43,mrVI (vs ctrl)
+X22,0.06513985941053602,1.0673082870539423,0.1369547982065098,0.47563035588073144,0.6343377451157035,-0.20328661258417396,0.333566331405246,False,43,mrVI (vs ctrl)
+X13,-0.05421145252079154,0.9472317907739788,0.09510324184369102,-0.570027387813887,0.5686591224904942,-0.2406103813474286,0.1321874763058455,False,43,mrVI (vs ctrl)
+X19,-0.04371732942057326,0.9572244984378745,0.12197384584593438,-0.3584156022742186,0.7200323172661145,-0.2827816743344451,0.19534701549329858,False,43,mrVI (vs ctrl)
+X28,0.04367534533321702,1.0446431515551753,0.15292185285209456,0.2856056509821369,0.7751801748153777,-0.256045978706022,0.3433966693724561,False,43,mrVI (vs ctrl)
+X9,-0.03884461600955731,0.9619001614203097,0.12089880883255523,-0.32129858337444067,0.7479841298554952,-0.27580192709515855,0.1981126950760439,False,43,mrVI (vs ctrl)
+X27,0.03315710433868614,1.0337129272708696,0.12669270351564726,0.26171281706519944,0.7935428582744412,-0.21515603165599356,0.2814702403333659,False,43,mrVI (vs ctrl)
+X17,0.01538573634626608,1.0155047061506421,0.10679965715289255,0.1440616642077804,0.8854517764131487,-0.1939377452346289,0.22470921792716106,False,43,mrVI (vs ctrl)
+approval_rate,0.6200197434906008,1.8589647439369763,0.050710832389389844,12.226573973972604,2.241966443217681e-34,0.5206283383813495,0.7194111485998522,True,5235,mrVI (vs ctrl)
+const,-0.5760994448582473,0.562086545800545,0.04126894579278935,-13.959635599872904,2.7483544226830264e-44,-0.6569850922920502,-0.4952137974244444,True,5235,mrVI (vs ctrl)
+X6,0.48901804334271193,1.6307141428902463,0.16778566741440654,2.914540025250831,0.003562131280773532,0.1601641780884594,0.8178719085969645,True,5235,mrVI (vs ctrl)
+X4,0.43429826694559137,1.5438792876085927,0.14023198199911138,3.0969987071019465,0.0019549072648570253,0.15944863274666388,0.7091479011445189,True,5235,mrVI (vs ctrl)
+X18,0.40272173748485685,1.4958905834686511,0.15894921307743165,2.5336504012050196,0.011288128705171837,0.09118700448210781,0.7142564704876059,True,5235,mrVI (vs ctrl)
+X16,0.36791115904544475,1.4447136835296497,0.1327907269443776,2.7706088181861723,0.005595160091116688,0.10764611675357211,0.6281762013373173,True,5235,mrVI (vs ctrl)
+X5,0.35963795544829413,1.432810579381391,0.11919923307924009,3.017116353502187,0.002551918388913144,0.12601175162818812,0.5932641592684001,True,5235,mrVI (vs ctrl)
+X3,0.33169514892031493,1.3933280262088925,0.13924348280155488,2.3821233299158115,0.017213131543063014,0.05878293754734493,0.6046073602932849,True,5235,mrVI (vs ctrl)
+X12,-0.3054114357518247,0.7368201578632348,0.14361321721587367,-2.1266248446529987,0.033451266512996375,-0.5868881691988648,-0.023934702304784672,True,5235,mrVI (vs ctrl)
+X10,0.26460576514090667,1.3029172191283394,0.13820937487183257,1.9145283406880818,0.055552681481186146,-0.0062796319336803075,0.5354911622154936,False,5235,mrVI (vs ctrl)
+X8,-0.24911851260612286,0.7794875888048501,0.21097018071866372,-1.1808233360634568,0.23767291161092796,-0.6626124686266103,0.16437544341436458,False,5235,mrVI (vs ctrl)
+X28,0.24437169513281926,1.276818829643949,0.13986097199576167,1.7472472244810702,0.08059446327960484,-0.029750772821638682,0.5184941630872772,False,5235,mrVI (vs ctrl)
+X25,-0.2438988544244875,0.7835668845783788,0.13224503651578945,-1.8442949607062726,0.06514016551087601,-0.5030943631296192,0.01529665428064414,False,5235,mrVI (vs ctrl)
+X30,0.22544752132289134,1.252883282733886,0.10736007850445942,2.0999194902183955,0.035735923943769655,0.015025634076758054,0.4358694085690246,True,5235,mrVI (vs ctrl)
+X24,0.19973721185505275,1.2210818301650026,0.14564707582328262,1.371378111960168,0.17025711703686908,-0.08572581121215564,0.48520023492226116,False,5235,mrVI (vs ctrl)
+X20,-0.18854600706213465,0.8281624012431121,0.19215503373652768,-0.9812181518005845,0.32648517472480565,-0.565162952633808,0.18807093850953865,False,5235,mrVI (vs ctrl)
+X21,-0.17469263709596253,0.8397150783735614,0.11316435390356525,-1.5437072812241703,0.12265926159151984,-0.3964906950806951,0.04710542088877004,False,5235,mrVI (vs ctrl)
+X29,-0.16874219307687294,0.8447266516952745,0.1335704023188551,-1.2633202427140768,0.20647411426657225,-0.4305353710223543,0.09305098486860841,False,5235,mrVI (vs ctrl)
+X14,-0.1443691533894514,0.8655681616539562,0.1644404703470215,-0.8779417444184313,0.379975333731998,-0.46666655287044023,0.17792824609153746,False,5235,mrVI (vs ctrl)
+X23,0.13663091042649872,1.1464049443131161,0.12063060732345299,1.1326388340244637,0.25736595353617553,-0.09980073536066283,0.37306255621366025,False,5235,mrVI (vs ctrl)
+X26,0.12367529235895953,1.1316483564667001,0.17837335082112107,0.6933507263816856,0.4880894763770942,-0.22593005105216585,0.4732806357700849,False,5235,mrVI (vs ctrl)
+X22,0.1051741832164793,1.110904094352738,0.11457285903293388,0.9179676941311822,0.35863577933030355,-0.1193844940938557,0.3297328605268143,False,5235,mrVI (vs ctrl)
+X27,0.08915000231289127,1.0932446332511074,0.12760046121893884,0.6986652043516232,0.4847612841381381,-0.16094230608692872,0.33924231071271127,False,5235,mrVI (vs ctrl)
+X2,-0.07783547099974154,0.925116622535897,0.12497519278900317,-0.6228073689084195,0.5334111153271307,-0.3227823478271376,0.16711140582765455,False,5235,mrVI (vs ctrl)
+X7,0.07295728084590142,1.075684583597679,0.1529718246733203,0.4769328011985585,0.6334099737660652,-0.22686198616318198,0.3727765478549848,False,5235,mrVI (vs ctrl)
+X1,-0.06181362534375595,0.9400580734656954,0.10577988986187913,-0.5843608404628553,0.5589775671159016,-0.26913839976165266,0.14551114907414073,False,5235,mrVI (vs ctrl)
+X13,0.05921285233691493,1.061001053260601,0.10459049679585791,0.5661398898648308,0.5712986883604799,-0.1457807545081185,0.26420645918194835,False,5235,mrVI (vs ctrl)
+X11,-0.05100868681082626,0.950270415677238,0.11274779654371245,-0.4524140459902481,0.6509707300426766,-0.27199030737275226,0.16997293375109973,False,5235,mrVI (vs ctrl)
+X17,0.031502841217786605,1.0320043077404755,0.09061638937564528,0.34765058986397374,0.7281026081020637,-0.14610201836753614,0.20910770080310934,False,5235,mrVI (vs ctrl)
+X9,0.014893120401364071,1.0150045755365407,0.13811917689029465,0.10782804196113466,0.9141320983036542,-0.25581549187793035,0.2856017326806585,False,5235,mrVI (vs ctrl)
+X15,-0.013620249633538287,0.9864720862783954,0.1078138338110694,-0.12633118730761503,0.899469770117651,-0.22493148093842108,0.19769098167134452,False,5235,mrVI (vs ctrl)
+X19,-0.0036904276691139947,0.9963163735899858,0.1152798722151575,-0.03201276682737996,0.9744618696603767,-0.22963482535320234,0.22225397001497438,False,5235,mrVI (vs ctrl)
+const,-1.0797956109888642,0.33966494233237426,0.04146571971798042,-26.040681756710033,1.7155008077470342e-149,-1.1610669282291382,-0.9985242937485902,True,332,mrVI (vs ctrl)
+X6,0.6139983972510716,1.8478049059091635,0.19980852060591028,3.072934003961139,0.0021196535925945663,0.22238089305925823,1.005615901442885,True,332,mrVI (vs ctrl)
+approval_rate,0.496375857112187,1.642756883656601,0.04362973176294338,11.377009141591389,5.4434681044071556e-30,0.41086315420167474,0.5818885600226993,True,332,mrVI (vs ctrl)
+X18,0.4367638586404417,1.5476905601481599,0.1604846931736084,2.7215296985860284,0.006498054603795448,0.12221963995020818,0.7513080773306753,True,332,mrVI (vs ctrl)
+X30,0.3723295051318302,1.451111051063793,0.13123220648716946,2.837180865112047,0.004551382155347096,0.11511910680525445,0.6295399034584059,True,332,mrVI (vs ctrl)
+X26,0.3676985137801704,1.444406504666393,0.17854297303837918,2.059439850937907,0.03945212149764671,0.017760716932241294,0.7176363106280994,True,332,mrVI (vs ctrl)
+X15,0.35536574655986747,1.4267023703516462,0.12906628874372228,2.7533583712590657,0.005898728648684839,0.10240046900392441,0.6083310241158105,True,332,mrVI (vs ctrl)
+X2,-0.2817779932671462,0.7544411569587849,0.12057991857059933,-2.3368567221428806,0.019446635298505578,-0.5181102909242933,-0.04544569560999909,True,332,mrVI (vs ctrl)
+X4,0.2686463954720336,1.308192476468012,0.1615606879743147,1.6628203236838386,0.09634840712231102,-0.048006734275136576,0.5852995252192038,False,332,mrVI (vs ctrl)
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data/coefficients_mrVI.csv

@@ -0,0 +1,161 @@
+Feature,Coefficient,Odds_Ratio,HC_Std_Error,z_value,p_value,CI_Lower_95,CI_Upper_95,Significant,split_seed,X_features
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+X30,0.16232742262762695,1.1762453076072026,0.07481236925735187,2.1697939022519983,0.03002246252208294,0.015697873285105746,0.30895697197014815,True,2132,mrVI
+X29,0.16056513546513598,1.1741742510358695,0.11204396274520095,1.4330547718155682,0.15184218529249394,-0.05903699620060546,0.38016726713087745,False,2132,mrVI
+X28,0.15931530169790808,1.1727076451060359,0.13253368895093237,1.202074000648175,0.22933485852558233,-0.10044595538415346,0.41907655877996963,False,2132,mrVI
+X4,0.1590030879167602,1.172341566768301,0.14920500911110443,1.0656685647755948,0.2865734926383616,-0.13343335625397512,0.45143953208749554,False,2132,mrVI
+X5,-0.13860678216742217,0.8705702849237132,0.07649698235441342,-1.8119248354824207,0.06999781134892737,-0.2885381125080685,0.011324548173224175,False,2132,mrVI
+X2,0.13459257988493553,1.144070572021528,0.06794420021740336,1.9809281653809316,0.04759932997919062,0.0014243945004464575,0.2677607652694246,True,2132,mrVI
+X12,0.10928910504837015,1.115484796014774,0.09321621189124923,1.1724259421298129,0.24102608915860135,-0.07341131303373268,0.291989523130473,False,2132,mrVI
+X3,-0.09225944536950566,0.9118685387826493,0.1077009749585115,-0.8566259071010804,0.39165166320791867,-0.3033494773880384,0.11883058664902711,False,2132,mrVI
+X22,-0.09121600297301621,0.912820517657225,0.11098187868608932,-0.8218999718955866,0.41113382898348705,-0.30873648813434473,0.1263044821883123,False,2132,mrVI
+X26,0.07990039804391261,1.083179175537237,0.12014881732617286,0.6650119395433062,0.5060428565090002,-0.15558695670046824,0.31538775278829345,False,2132,mrVI
+X10,-0.07954397618157454,0.9235374054269447,0.09536065966273907,-0.8341382752897976,0.4042030687654886,-0.26644743466252463,0.10735948229937554,False,2132,mrVI
+X19,0.06877410503397793,1.0711942044371379,0.09301110303050834,0.7394182285035316,0.4596530767823831,-0.11352430706816269,0.25107251713611856,False,2132,mrVI
+X25,-0.05256449467526664,0.9487931269778568,0.07831352046432404,-0.6712058705011551,0.5020893894011289,-0.20605617428788223,0.10092718493734895,False,2132,mrVI
+X16,0.05098461307109686,1.0523067013902339,0.0898556890692412,0.5674055098704883,0.5704387073058235,-0.12512930131064529,0.227098527452839,False,2132,mrVI
+X1,-0.04583811588634516,0.9551965808270798,0.09242411696175742,-0.4959540582390603,0.6199268248202269,-0.22698605643430725,0.1353098246616169,False,2132,mrVI
+X14,-0.04319995448084609,0.9577198705405651,0.12603811752321178,-0.3427530919199121,0.7317842177564061,-0.29023012550556787,0.20383021654387568,False,2132,mrVI
+X23,0.03781165038780886,1.0385356066772522,0.11996090549495568,0.3151997747249317,0.7526099765961906,-0.19730740393511736,0.27293070471073505,False,2132,mrVI
+X18,0.03249662689746786,1.0330304086206088,0.10057360016993415,0.32311289287208517,0.7466097464353145,-0.16462400723113454,0.22961726102607025,False,2132,mrVI
+X27,0.03228067878445589,1.0328073517384062,0.12491504675040072,0.25842105994610565,0.7960819649613773,-0.21254831397346663,0.2771096715423784,False,2132,mrVI
+X24,0.028529780392912395,1.0289406526351783,0.10181908237906287,0.28020072196976503,0.779323512795673,-0.17103195400896767,0.22809151479479248,False,2132,mrVI
+X6,0.027971993677423576,1.0283668832434603,0.0879554375391849,0.3180246095070792,0.7504662695675288,-0.14441749614384108,0.20036148349868826,False,2132,mrVI
+X15,-0.01755853091226805,0.9825947218164629,0.08510811190192999,-0.20630854709244084,0.8365499025328385,-0.18436736503225556,0.14925030320771945,False,2132,mrVI
+X13,0.01735125767623333,1.0175026651835892,0.07387353228919001,0.2348778667887302,0.8143035288060954,-0.12743820502133588,0.16214072037380253,False,2132,mrVI
+X20,-0.016858487269481148,0.9832828218268245,0.11155041361373676,-0.15112886383242533,0.8798740639505288,-0.23549328041295173,0.20177630587398945,False,2132,mrVI
+X9,-0.005537324445440133,0.9944779782771581,0.08633146387044098,-0.06414028208475749,0.9488585273974288,-0.17474388436412536,0.16366923547324508,False,2132,mrVI

data/drug_metadata.csv

@@ -0,0 +1,380 @@
+,drug,targets,moa-broad,moa-fine,human-approved,clinical-trials,gpt-notes-approval,canonical_smiles,pubchem_cid
+0,Talc,,unclear,unclear,yes,yes,Talc used in pharma and cosmetics; safety under review for some uses.,[OH-].[OH-].[O-][Si]12O[Si]3(O[Si](O1)(O[Si](O2)(O3)[O-])[O-])[O-].[Mg+2].[Mg+2].[Mg+2],165411828.0
+1,Bortezomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma and mantle cell lymphoma.,B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O,387447.0
+2,Ixazomib,PSMB5,inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma treatment.,B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O,25183872.0
+3,Ixazomib citrate,"PSMB1, PSMB2, PSMB5",inhibitor/antagonist,Proteasome inhibitor,yes,yes,Approved for multiple myeloma treatment as part of a combination therapy.,B1(OC(=O)C(O1)(CC(=O)O)CC(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl,56844015.0
+4,Lactate (calcium),,unclear,unclear,yes,yes,"Used in medical settings, but not specifically approved as a standalone drug.",C.CC(C(=O)[O-])O.[Ca+2],168311648.0
+5,Bisoprolol (hemifumarate),ADRB1,inhibitor/antagonist,Adrenoceptor agonist,yes,yes,"Approved for hypertension, heart failure, and angina.",C.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O,168312271.0
+6,Fumaric acid,,inhibitor/antagonist,unclear,yes,yes,Used in psoriasis treatment as part of fumaric acid esters.,C(=CC(=O)O)C(=O)O,444972.0
+7,Hydroxyurea,"RRM2, RRM1",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for sickle cell anemia and certain cancers.,C(=O)(N)NO,3657.0
+8,L-Eflornithine (monohydrochloride),ODC1,inhibitor/antagonist,unclear,yes,yes,Used to treat sleeping sickness. Approved for human use.,C(CC(C(F)F)(C(=O)O)N)CN.Cl,16048568.0
+9,Cysteamine (hydrochloride),,unclear,unclear,yes,yes,FDA-approved for cystinosis treatment.,C(CS)N.Cl,9082.0
+10,Darinaparsin,,unclear,unclear,no,yes,Used in clinical trials for certain cancers only.,C[As](C)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N,11683005.0
+11,Entecavir (monohydrate),,unclear,unclear,yes,yes,Approved for treating hepatitis B infection.,C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N.O,135526609.0
+12,Allantoin,,unclear,unclear,yes,yes,Allantoin is approved as a skin protectant by the FDA.,C1(C(=O)NC(=O)N1)NC(=O)N,204.0
+13,5-Fluorouracil,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used chemotherapy drug. Approved for cancer treatment.,C1=C(C(=O)NC(=O)N1)F,3385.0
+14,L-Thyroxine (sodium salt pentahydrate),,unclear,unclear,yes,yes,"Approved for hypothyroidism, a form of standard thyroid hormone replacement therapy.",C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.O.O.O.O.O.[Na+],23665037.0
+15,Gallic acid,,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,"Used in supplements, studied for antioxidant properties.",C1=C(C=C(C(=C1O)O)O)C(=O)O,370.0
+16,Gallic acid (hydrate),,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Evaluated in trials but not approved as a standalone drug.,C1=C(C=C(C(=C1O)O)O)C(=O)O.O,24721416.0
+17,ERK5-IN-2,MAPK7,inhibitor/antagonist,Other MAPK inhibitor,no,no,Not found in clinicaltrials.gov database as of the latest available data.,C1=CC(=C(C(=C1)Br)C(=O)C2=CNC(=C2)C(=O)NC3=CN=CC=C3)F,118959080.0
+18,Vilanterol,ADRB2,activator/agonist,Adrenoceptor agonist,yes,yes,Combined with fluticasone furoate for asthma and COPD treatment.,C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)Cl,10184665.0
+19,Niclosamide (olamine),STAT3,inhibitor/antagonist,unclear,yes,yes,"Approved for parasitic infections, investigated for other uses.",C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.C(CO)N,14992.0
+20,Norepinephrine (hydrochloride),"ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1",activator/agonist,Adrenoceptor agonist,yes,yes,Approved for human use as a medication to treat low blood pressure.,C1=CC(=C(C=C1C(CN)O)O)O.Cl,11672905.0
+21,Triclosan,,inhibitor/antagonist,unclear,no,yes,Banned in soaps; used in some consumer products and healthcare settings.,C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl,5564.0
+22,Mitoxantrone (dihydrochloride),"TOP2A, TOP2B, PRKCA",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer and multiple sclerosis treatment.,C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl,51082.0
+23,Pentamidine (isethionate),PRLR,inhibitor/antagonist,unclear,yes,yes,Used to treat Pneumocystis pneumonia and African trypanosomiasis.,C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O,8813.0
+24,Folic acid,,unclear,unclear,yes,yes,Widely used as a dietary supplement and in fortified foods.,C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N,135398658.0
+25,Balsalazide (sodium hydrate),"IL6, STAT3",unclear,JAK/STAT inhibitor,yes,yes,Used for ulcerative colitis treatment in humans.,C1=CC(=CC=C1C(=O)NCCC(=O)[O-])N=NC2=CC(=C(C=C2)[O-])C(=O)O.O.O.[Na+].[Na+],92044433.0
+26,Resveratrol,SIRT1,unclear,unclear,no,yes,"Studies showed promising results, but no approval for therapeutic use.",C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O,445154.0
+27,PF-06260933,MAP4K4,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for treating pain; not approved for human use.,C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl,118701008.0
+28,Daidzin,ALDH2,inhibitor/antagonist,unclear,no,yes,investigated for alcoholism; not approved for treatment,C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O,107971.0
+29,Pemetrexed,"TYMS, DHFR, GART",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Chemotherapy drug for mesothelioma and non-small cell lung cancer.,C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O,135410875.0
+30,Econazole,,unclear,unclear,yes,yes,Antifungal approved for dermatological use.,C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl,3198.0
+31,XRK3F2,,inhibitor/antagonist,unclear,no,no,No results found on clinicaltrials.gov,C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl,135397144.0
+32,Arbutin,"MYC, KLF4",inhibitor/antagonist,unclear,no,yes,"Used in cosmetics, trials for skin-lightening, not approved as a drug.",C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O,440936.0
+33,Tucidinostat,"HDAC1, HDAC2, HDAC3, HDAC10, HDAC8, HDAC11",inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for use in China for certain cancers.,C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N,12136798.0
+34,Pexidartinib (hydrochloride),"CSF1R, KIT, FLT3",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for tenosynovial giant cell tumor in 2019.,C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl,73053710.0
+35,Sodium Salicylate,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,"Used in studies, NSAID-related research, not approved for standard human therapy.",C1=CC=C(C(=C1)C(=O)[O-])O.[Na+],16760658.0
+36,Salicylic acid,,inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used topically for acne and in aspirin synthesis.,C1=CC=C(C(=C1)C(=O)O)O,338.0
+37,Ataluren,CFTR,inhibitor/antagonist,unclear,yes,yes,For Duchenne muscular dystrophy with specific genetic mutation.,C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F,11219835.0
+38,4EGI-1,EIF4E,inhibitor/antagonist,Protein synthesis inhibitor,no,no,No clinical trials found for 4EGI-1 on clinicaltrials.gov.,C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-],5717952.0
+39,Clotrimazole,"CYP2A6, CYP51A1",inhibitor/antagonist,unclear,yes,yes,Antifungal used in topical and oral preparations.,C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4,2812.0
+40,Phenytoin (sodium),,inhibitor/antagonist,unclear,yes,yes,Commonly used as an anti-seizure medication.,C1=CC=C(C=C1)C2(C(=O)NC(=N2)[O-])C3=CC=CC=C3.[Na+],23679632.0
+41,SBI-0640756,,inhibitor/antagonist,Protein synthesis inhibitor,no,no,No record found on clinicaltrials.gov.,C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)C=CC4=CC(=CN=C4)F,121241171.0
+42,Oxaprozin,"PTGS1, PTGS2, NFKB1",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for arthritis treatment.,C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3,4614.0
+43,Baicalin,,activator/agonist,unclear,no,yes,"Used in traditional medicine, researched for various pharmacological effects.",C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O,64982.0
+44,Belinostat,HDAC6,inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for relapsed/refractory peripheral T-cell lymphoma.,C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO,6918638.0
+45,Carbamazepine,,inhibitor/antagonist,HDAC inhibitor,yes,yes,Used for epilepsy and neuropathic pain.,C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N,2554.0
+46,HI-TOPK-032,PBK,inhibitor/antagonist,unclear,no,no,No results found on clinicaltrials.gov.,C1=CC=C2C(=C1)N=C3C(=C4C=C(C=CN4C3=N2)NC(=O)C5=CC=CS5)C#N,1936439.0
+47,8-Hydroxyquinoline,,unclear,unclear,no,yes,"Used in some clinical trial formulations, not approved as standalone drug.",C1=CC2=C(C(=C1)O)N=CC=C2,1923.0
+48,Riluzole hydrochloride,,inhibitor/antagonist,unclear,yes,yes,Used in ALS treatment.,C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl,6419992.0
+49,Minodronic acid,"P2RX2, P2RX3",inhibitor/antagonist,unclear,no,yes,Investigated for osteoporosis; not approved in major markets.,C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O,130956.0
+50,GSK1059615,"PIK3CA, PIK3CB, PIK3CD, PIK3CG, MTOR",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,"Investigated in trials, not approved for human use.",C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4,23582824.0
+51,Gemcitabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment like pancreatic and non-small cell lung cancer.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F,60750.0
+52,Cytarabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapy for leukemia and other cancers.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O,6253.0
+53,Cytarabine (hydrochloride),,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapy for leukemia and lymphoma.,C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl,6252.0
+54,Uridine,,unclear,unclear,no,yes,"Studied in trials; not approved as standalone drug, essential body metabolite.",C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O,6029.0
+55,Selinexor,XPO1,inhibitor/antagonist,unclear,yes,yes,Approved for certain cancer treatments.,C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F,71481097.0
+56,Furosemide,"SLC12A1, SLC12A2",inhibitor/antagonist,unclear,yes,yes,"Widely used diuretic, approved for various conditions like hypertension and edema.",C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl,3440.0
+57,Adenosine,"ADORA1, ADORA2A, ADORA2B, ADORA3",unclear,unclear,yes,yes,Used for certain arrhythmias; approved as a drug.,C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N,60961.0
+58,5-Azacytidine,DNMT1,inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,"Approved for use in specific cancers, such as myelodysplastic syndromes.",C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N,9444.0
+59,Clofarabine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for leukemia treatment in pediatric patients.,C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N,119182.0
+60,Adenine,,unclear,unclear,no,no,Commonly found in supplements; not a drug approved by itself.,C1=NC2=NC=NC(=C2N1)N,190.0
+61,Allopurinol,XDH,inhibitor/antagonist,unclear,yes,yes,"Approved for gout treatment, reduces uric acid levels.",C1=NNC2=C1C(=O)NC=N2,135401907.0
+62,Trifluridine,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used to treat viral infections and in cancer therapy (with tipiracil).,C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O,6256.0
+63,Brivudine,,unclear,unclear,yes,yes,"Approved in Europe, not widely used in the US.",C1C(C(OC1N2C=C(C(=O)NC2=O)C=CBr)CO)O,446727.0
+64,Idoxuridine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as topical antiviral in eye infections. Approved for human use.,C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O,5905.0
+65,Decitabine,"DNMT1, DNMT3A, DNMT3B",inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,Approved for treatment of myelodysplastic syndromes and acute myeloid leukemia.,C1C(C(OC1N2C=NC(=NC2=O)N)CO)O,451668.0
+66,Lenalidomide (hemihydrate),"CRBN, IKZF1, IKZF3",inhibitor/antagonist,unclear,yes,yes,Approved for multiple myeloma and other conditions.,C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.O,46220375.0
+67,DT-061,,activator/agonist,unclear,no,yes,"Investigated for oncology, no approval yet for human use.",C1CC(C(C(C1)N2C3=CC=CC=C3OC4=CC=CC=C42)O)NS(=O)(=O)C5=CC=C(C=C5)OC(F)(F)F,91885558.0
+68,BAY1125976,"AKT1, AKT2, AKT3",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,Cancer treatment trials but not approved for human use.,C1CC(C1)(C2=CC=C(C=C2)C3=C(N4C(=N3)C=CC(=N4)C(=O)N)C5=CC=CC=C5)N,70817911.0
+69,Larotrectinib,"NTRK1, NTRK2, NTRK3",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved specifically as a cancer treatment for tumors with NTRK gene fusions.,C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F,46188928.0
+70,Larotrectinib sulfate,"NTRK1, NTRK2, NTRK3",inhibitor/antagonist,Other TK inhibitor,yes,yes,Larotrectinib sulfate is approved to treat TRK fusion-positive cancers.,C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O,67330085.0
+71,olaparib,"PARP1, PARP2",unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for BRCA-mutated cancers.,C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F,23725625.0
+72,Filgotinib,"JAK1, JAK2, TYK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved in Japan and EU for rheumatoid arthritis.,C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5,49831257.0
+73,ULK-101,"ULK1, ULK2",inhibitor/antagonist,unclear,no,no,No clinical trial data found on clinicaltrials.gov.,C1CC1C(C(F)(F)F)NC(=O)C2=CC(=CS2)C3=C4N=CC(=CN4N=C3)C5=CC=C(C=C5)F,137628686.0
+74,Oxaliplatin,,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for use in chemotherapy treatments.,C1CCC(C(C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2],9887053.0
+75,Cilostazol,PDE3A,inhibitor/antagonist,unclear,yes,yes,Used to treat intermittent claudication associated with peripheral artery disease.,C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4,2754.0
+76,LY2090314,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,yes,Investigated for Alzheimer's; not approved for any condition.,C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7,10029385.0
+77,Cobimetinib,MAP2K1,inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma in combination with vemurafenib.,C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O,16222096.0
+78,Asciminib,ABL1,inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for chronic myeloid leukemia (CML) treatment.,C1CN(CC1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4,72165228.0
+79,Capivasertib,"AKT1, AKT2, AKT3, RPS6KB1, PRKACA, ROCK2, ROCK1",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,In clinical trials for cancer. Not yet approved for human use.,C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4,25227436.0
+80,Penfluridol,DRD2,inhibitor/antagonist,unclear,yes,yes,Long-acting antipsychotic drug approved for human use.,C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F,33630.0
+81,Lonafarnib,"HRAS, KRAS, NRAS",inhibitor/antagonist,RAS inhibitor,yes,yes,Approved for progeria treatment in children.,C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3N=CC(=C5)Br)C=C(C=C4Br)Cl)C(=O)N,148195.0
+82,Pimozide,"DRD2, DRD3",inhibitor/antagonist,unclear,yes,yes,Approved antipsychotic used mainly for Tourette's syndrome and chronic schizophrenia.,C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F,16362.0
+83,Clonidine (hydrochloride),"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Used for hypertension and ADHD among other conditions.,C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl,20179.0
+84,Brimonidine,"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Used in the form of brimonidine tartrate for glaucoma treatment.,C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br,2435.0
+85,AT7519,"CDK2, CDK4, CDK5, CDK6, CDK9, CDK1, CDK7, GSK3B",inhibitor/antagonist,CDK inhibitor,no,yes,Tested in trials for cancer treatments.,C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl,11338033.0
+86,Hydroxyfasudil,"ROCK1, ROCK2, PRKACA",inhibitor/antagonist,unclear,no,yes,"Studied for therapeutic potential; derivative of fasudil, which is approved.",C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O,3064778.0
+87,BI-78D3,,inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigated for Alzheimer's and inflammatory diseases, not approved for human use.",C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-],2747117.0
+88,ETC-206,,inhibitor/antagonist,Protein synthesis inhibitor,no,yes,"Investigational drug for cancer, not yet approved for human use.",C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3,71766360.0
+89,LJI308,"RPS6KA1, RPS6KA3, RPS6KA2",inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigational compound, not approved for human use as a drug.",C1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F,118704762.0
+90,Bimiralisib,"PIK3CA, PIK3CB, MTOR",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,Investigational PI3K/mTOR inhibitor; not approved for human use as of 2023.,C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4,58507717.0
+91,Bentamapimod,"MAPK8, MAPK9, MAPK10",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for ovarian cancer; not approved for human use.,C1COCCN1CC2=CC=C(C=C2)COC3=NC=CC(=N3)C(C#N)C4=NC5=CC=CC=C5S4,10195250.0
+92,Lipoic acid,,unclear,unclear,yes,yes,"Approved as dietary supplement, not as a drug for specific indications.",C1CSSC1CCCCC(=O)O,6112.0
+93,Peretinoin,"RXRA, RXRB, RXRG",unclear,Retinoic receptor agonist,no,yes,"Studied for liver cancer, not approved for human use.",CC(=CCCC(=CCCC(=CC=CC(=CC(=O)O)C)C)C)C,6437836.0
+94,IQ 1,,unclear,unclear,no,yes,Investigational drug; not approved for human use yet.,CC(=O)C1=CC=C(C=C1)NN=C(C2=NC(CC3=CC=CC=C32)(C)C)C(=O)N,5823908.0
+95,Acetohexamide,,activator/agonist,unclear,yes,yes,"First-generation sulfonylurea, used for type 2 diabetes treatment.",CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2,1989.0
+96,Pentoxifylline,,inhibitor/antagonist,unclear,yes,yes,Used to improve blood flow in peripheral artery disease.,CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C,4740.0
+97,DTP3,,inhibitor/antagonist,unclear,no,yes,Currently being investigated in clinical trials in the UK.,CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)N,86295191.0
+98,Acetazolamide,,inhibitor/antagonist,unclear,yes,yes,"Used to treat glaucoma, epilepsy, and altitude sickness since 1950s.",CC(=O)NC1=NN=C(S1)S(=O)(=O)N,1986.0
+99,Pasireotide (acetate),"SSTR1, SSTR2, SSTR3, SSTR5",activator/agonist,unclear,yes,yes,Approved for Cushing's disease and acromegaly.,CC(=O)O.C1C(CN2C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C2=O)CC3=CC=CC=C3)CC4=CC=C(C=C4)OCC5=CC=CC=C5)CCCCN)CC6=CNC7=CC=CC=C76)C8=CC=CC=C8)OC(=O)NCCN,72205932.0
+100,Chlorhexidine (diacetate),,unclear,unclear,yes,yes,Used as antiseptic and disinfectant. Approved for human use.,CC(=O)O.CC(=O)O.C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl,9562059.0
+101,Aspirin,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used widely for pain relief and anti-inflammatory purposes.,CC(=O)OC1=CC=CC=C1C(=O)O,2244.0
+102,Abiraterone acetate,CYP17A1,inhibitor/antagonist,unclear,yes,yes,Approved for prostate cancer treatment.,CC(=O)OC1CCC2(C3CCC4(C(C3CC=C2C1)CC=C4C5=CN=CC=C5)C)C,9821849.0
+103,Sivelestat (sodium tetrahydrate),ELANE,inhibitor/antagonist,unclear,no,yes,"Approved in Japan, not approved in US/EU.",CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+],23663985.0
+104,Atazanavir (sulfate),CYP3A4,inhibitor/antagonist,unclear,yes,yes,"Antiretroviral, approved for HIV treatment.",CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O,158550.0
+105,Terfenadine,HRH1,inhibitor/antagonist,unclear,no,yes,Withdrawn due to cardiac toxicity; replaced by fexofenadine.,CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O,5405.0
+106,Bosentan (hydrate),"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Approved for treating pulmonary arterial hypertension.,CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC.O,185462.0
+107,Dabrafenib,"BRAF, RAF1",inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for melanoma treatment.,CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F,44462760.0
+108,Ralimetinib dimesylate,"MAPKAPK2, MAPK14, MAPK11",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated as cancer treatment; not approved for human use.,CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O,11570805.0
+109,Saquinavir,,inhibitor/antagonist,unclear,yes,yes,Approved as part of antiretroviral therapy for HIV/AIDS.,CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)NC(=O)C4=NC5=CC=CC=C5C=C4)O,441243.0
+110,Pentagastrin,CCKBR,inhibitor/antagonist,unclear,yes,yes,Used mainly in diagnostic tests for gastric functions.,CC(C)(C)OC(=O)NCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N,9853654.0
+111,Anastrozole,CYP19A1,inhibitor/antagonist,unclear,yes,yes,Used to treat breast cancer in postmenopausal women.,CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N,2187.0
+112,Harringtonine,,unclear,Protein synthesis inhibitor,no,yes,"Investigated in trials mainly for cancer treatment, often used as basis for derivatives.",CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,276389.0
+113,Homoharringtonine,,inhibitor/antagonist,Protein synthesis inhibitor,yes,yes,"Used in leukemia treatment, also known as Omacetaxine.",CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O,285033.0
+114,Flutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Used to treat prostate cancer as an antiandrogen.,CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F,3397.0
+115,Thymopentin,,unclear,unclear,no,yes,In clinical trials for immune deficiency and autoimmune diseases.,CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N,451417.0
+116,Aliskiren,REN,inhibitor/antagonist,unclear,yes,yes,Renin inhibitor for hypertension. Approved in the US and EU.,CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N,5493444.0
+117,Verapamil,"CYP3A4, ABCB1",inhibitor/antagonist,unclear,yes,yes,Used as a racemic mixture for hypertension and angina.,CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC,2520.0
+118,(R)-Verapamil (hydrochloride),ABCB1,inhibitor/antagonist,unclear,no,yes,"Racemic verapamil is approved, but not specifically (R)-enantiomer alone.",CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl,170014.0
+119,Ritonavir,,inhibitor/antagonist,unclear,yes,yes,Used in combination HIV therapies.,CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O,392622.0
+120,Goserelin (acetate),GNRHR,activator/agonist,unclear,yes,yes,It's approved for prostate and breast cancer treatment.,CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O,16052011.0
+121,Bestatin,ANPEP,inhibitor/antagonist,unclear,no,yes,Studied in trials; not approved for human therapeutic use.,CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O,72172.0
+122,Bestatin (hydrochloride),,inhibitor/antagonist,unclear,no,yes,Investigated in clinical trials but not approved for human use.,CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O.Cl,11957481.0
+123,Imiquimod (maleate),TLR7,activator/agonist,unclear,yes,yes,"Approved for skin conditions; imiquimod itself, not specifically maleate salt.",CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N.C(=CC(=O)O)C(=O)O,11595577.0
+124,Imiquimod (hydrochloride),TLR7,activator/agonist,unclear,yes,yes,Approved for topical treatment of skin conditions like actinic keratosis.,CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N.Cl,13982876.0
+125,Encorafenib,BRAF,inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for use in BRAF-mutant melanoma.,CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC,50922675.0
+126,AZD1390,ATM,inhibitor/antagonist,unclear,no,yes,"Investigational ATM kinase inhibitor in clinical trials, not approved for human use.",CC(C)N1C2=C(C=NC3=CC(=C(C=C32)C4=CN=C(C=C4)OCCCN5CCCCC5)F)N(C1=O)C,126689157.0
+127,Sapanisertib,MTOR,inhibitor/antagonist,MTOR inhibitor,no,yes,"Investigational mTOR inhibitor, not approved yet but studied for cancer treatment.",CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N,45375953.0
+128,Torkinib,"MTOR, PDGFRA, PRKDC, PIK3CD, PIK3CG, PIK3CA, PIK3CB, HCK, SRC, KDR, ABL1, EPHB4, EGFR",inhibitor/antagonist,MTOR inhibitor,no,yes,In clinical trials for cancer treatment but not yet approved.,CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N,135565635.0
+129,Belumosudil,"ROCK2, ROCK1",inhibitor/antagonist,unclear,yes,yes,Approved for chronic graft-versus-host disease in the US.,CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5,11950170.0
+130,Belumosudil (mesylate),"ROCK2, ROCK1",inhibitor/antagonist,unclear,yes,yes,Approved for chronic graft-versus-host disease.,CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5.CS(=O)(=O)O,146681181.0
+131,Esmolol (hydrochloride),ADRB1,inhibitor/antagonist,unclear,yes,yes,Used as a beta-1 blocker for acute heart issues.,CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O.Cl,104769.0
+132,Erdafitinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for bladder cancer treatment.,CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC,67462786.0
+133,Malotilate,ALOX5,inhibitor/antagonist,unclear,no,yes,"Investigated, but not approved for human use.",CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C,4006.0
+134,Fenofibrate,"CYP2C19, CYP2B6, CYP2C9, CYP2C8, CYP3A4, PPARA",unclear,unclear,yes,yes,Fenofibrate is approved for human use in treating hypercholesterolemia.,CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl,3339.0
+135,MK-8353,"MAPK3, MAPK1",inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigated for cancer treatment in clinical trials.,CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)C4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC,58282870.0
+136,crizotinib,"ALK, MET, ROS1",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for NSCLC treatment.,CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N,11626560.0
+137,(S)-Crizotinib,NUDT1,inhibitor/antagonist,unclear,no,yes,"Racemic mixture Crizotinib is approved, not specific enantiomer.",CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N,56671814.0
+138,Crizotinib (hydrochloride),"ALK, MET, ROS1",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for ALK-positive NSCLC treatment.,CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl,71576688.0
+139,Aprepitant,TACR1,inhibitor/antagonist,unclear,yes,yes,Aprepitant is approved for preventing chemotherapy-induced nausea and vomiting.,CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F,135413536.0
+140,Cinacalcet,CASR,activator/agonist,unclear,yes,yes,Used to treat secondary hyperparathyroidism and parathyroid carcinoma.,CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F,156419.0
+141,Naproxen,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used as non-prescription NSAID in many countries.,CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O,156391.0
+142,Zileuton,ALOX5,inhibitor/antagonist,unclear,yes,yes,Approved for asthma treatment; 5-lipoxygenase inhibitor.,CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O,60490.0
+143,Voriconazole,,inhibitor/antagonist,unclear,yes,yes,Approved for treating invasive fungal infections.,CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O,71616.0
+144,Carbidopa (monohydrate),AHR,inhibitor/antagonist,unclear,yes,yes,Used in combination with levodopa for Parkinson's treatment.,CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN,2563.0
+145,Silodosin,"ADRA1A, ADRA1B, ADRA1D",inhibitor/antagonist,unclear,yes,yes,Approved for benign prostatic hyperplasia treatment.,CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F,5312125.0
+146,Darolutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Approved for treating non-metastatic castration-resistant prostate cancer.,CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=NNC(=C3)C(C)O,67171867.0
+147,Benproperine (phosphate),ARPC2,inhibitor/antagonist,unclear,yes,yes,Studied as a cough suppressant; not widely approved.,CC(COC1=CC=CC=C1CC2=CC=CC=C2)N3CCCCC3.OP(=O)(O)O,167811.0
+148,Bicalutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Approved as antiandrogen for prostate cancer treatment.,CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O,2375.0
+149,Captopril,ACE,inhibitor/antagonist,unclear,yes,yes,First ACE inhibitor approved for hypertension and heart failure.,CC(CS)C(=O)N1CCCC1C(=O)O,44093.0
+150,Tirabrutinib,BTK,inhibitor/antagonist,Other TK inhibitor,no,yes,"In clinical trials, not approved for human use yet.",CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N,54755438.0
+151,Tirabrutinib (hydrochloride),BTK,inhibitor/antagonist,Other TK inhibitor,no,yes,Not approved in US/EU; used investigationally in some regions.,CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl,71571562.0
+152,Mifepristone,"NR3C1, PGR",inhibitor/antagonist,unclear,yes,yes,Approved for medical abortion and Cushing's syndrome treatment.,CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O,55245.0
+153,Fostamatinib (disodium hexahydrate),"SYK, FLT3, LYN, LCK",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for treatment of chronic immune thrombocytopenia in adults.,CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.O.O.O.O.O.O.[Na+].[Na+],146673142.0
+154,Temuterkib,,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Temuterkib is in clinical trials for cancer treatment.,CC1(C2=C(C=C(S2)C3=NC(=NC=C3)NC4=CC=NN4C)C(=O)N1CCN5CCOCC5)C,121408882.0
+155,Tetracycline (hydrochloride),,unclear,unclear,yes,yes,Approved antibiotic often used as tetracycline hydrochloride.,CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl,54704426.0
+156,Glycyrrhizic acid,,inhibitor/antagonist,unclear,no,yes,"Tested for therapeutic effects, not approved for human use.",CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C,14982.0
+157,Diammonium Glycyrrhizinate,,unclear,unclear,no,yes,Used in trials for hepatitis. Not approved for general human use.,CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N.N,656656.0
+158,venetoclax,BCL2,inhibitor/antagonist,unclear,yes,yes,Approved for chronic lymphocytic leukemia and other cancers.,CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C,49846579.0
+159,Delamanid,,inhibitor/antagonist,unclear,yes,yes,Approved for MDR-TB treatment.,CC1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F,6480466.0
+160,Dexmedetomidine,"ADRA2A, ADRA2B, ADRA2C",activator/agonist,Adrenoceptor agonist,yes,yes,Approved as sedative and analgesic.,CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C,5311068.0
+161,Ranolazine,,inhibitor/antagonist,unclear,yes,yes,Approved for treating chronic angina.,CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O,56959.0
+162,Lopinavir,,inhibitor/antagonist,unclear,yes,yes,Combined with ritonavir for HIV treatment. Approved for human use.,CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O,92727.0
+163,Valdecoxib,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Withdrawn due to safety concerns related to cardiovascular risks.,CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N,119607.0
+164,Cloxacillin (sodium),,inhibitor/antagonist,unclear,yes,yes,Approved as a penicillinase-resistant antibiotic for human use.,CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+],23675320.0
+165,Elagolix sodium,GNRHR,inhibitor/antagonist,unclear,yes,yes,Approved for endometriosis pain in women.,CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)C(F)(F)F)CC(C3=CC=CC=C3)NCCCC(=O)[O-])C4=C(C(=CC=C4)OC)F.[Na+],24785956.0
+166,palbociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use as a cancer treatment.,CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C,5330286.0
+167,Retinoic acid,"RARB, RARG, RARA, PPARD",activator/agonist,Retinoic receptor agonist,yes,yes,Approved for acne and leukemia treatment.,CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C,444795.0
+168,PH-797804,MAPK14,inhibitor/antagonist,Other MAPK inhibitor,no,yes,"Investigated as an anti-inflammatory agent, not approved for human use.",CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C,22049997.0
+169,Ponatinib,"ABL1, PDGFRA, KDR, FGFR1, SRC, KIT",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for treatment of certain types of leukemia.,CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5,24826799.0
+170,Radotinib,ABL1,inhibitor/antagonist,Other TK inhibitor,no,yes,"Tested for chronic myeloid leukemia, not approved in major markets.",CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=NC=CN=C5,16063245.0
+171,NVP-BHG712,EPHB4,inhibitor/antagonist,unclear,no,yes,Investigated as angiogenesis inhibitor; not approved for human use.,CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=C4C=NN(C4=NC(=N3)C5=CN=CC=C5)C,16747388.0
+172,Canagliflozin,SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for type 2 diabetes treatment.,CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F,24812758.0
+173,MK-3903,PRKAA1,activator/agonist,unclear,no,yes,"Investigated for NASH, not yet approved for human use.",CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C(=O)O,45256689.0
+174,EX229,PRKAA1,activator/agonist,unclear,no,no,No clinical trial information found on clinicaltrials.gov.,CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O,45256693.0
+175,Flumatinib (mesylate),ABL1,inhibitor/antagonist,Other TK inhibitor,no,yes,Used in trials for chronic myeloid leukemia.,CC1=C(C=C(C=N1)NC(=O)C2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O,46910592.0
+176,Tucatinib,ERBB2,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use in advanced HER2-positive breast cancer.,CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5,51039094.0
+177,Trimetrexate,DHFR,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used with leucovorin for treating certain types of pneumonia.,CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC,5583.0
+178,APTO-253,"MYC, KLF4",unclear,unclear,no,yes,"Investigated for cancer, but development discontinued.",CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6,11960271.0
+179,Vitamin K4,,unclear,unclear,no,yes,Investigated in a clinical trial in Egypt.,CC1=C(C2=CC=CC=C2C(=C1)OC(=O)C)OC(=O)C,11310.0
+180,Panobinostat,"HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10, HDAC11",inhibitor/antagonist,HDAC inhibitor,yes,yes,Approved for multiple myeloma treatment.,CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO,6918837.0
+181,Rimonabant,CNR1,inhibitor/antagonist,unclear,no,yes,Withdrawn due to psychiatric side effects.,CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl,104850.0
+182,Rimonabant (Hydrochloride),CNR1,inhibitor/antagonist,unclear,no,yes,"Withdrawn due to psychiatric side effects, once used as anti-obesity drug.",CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl.Cl,104849.0
+183,Ligustrazine,,unclear,unclear,no,yes,"Mainly used in traditional Chinese medicine, limited human trials exist.",CC1=C(N=C(C(=N1)C)C)C,14296.0
+184,Sulfisoxazole,"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Discontinued in U.S.; previously used for bacterial infections.,CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N,5344.0
+185,Alpelisib,PIK3CA,inhibitor/antagonist,PI3K/AKT inhibitor,yes,yes,Approved for HR+/HER2- advanced breast cancer in combination with fulvestrant.,CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F,56649450.0
+186,Trametinib,"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,yes,yes,Approved for melanoma treatment.,CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5,11707110.0
+187,Nevirapine,,inhibitor/antagonist,unclear,yes,yes,Antiretroviral for HIV treatment approved for human use.,CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4,4463.0
+188,Tomivosertib,,inhibitor/antagonist,Protein synthesis inhibitor,no,yes,In clinical trials for cancer; not FDA approved for human use yet.,CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3,118598754.0
+189,Paclitaxel,,unclear,Microtubule inhibitor,yes,yes,Chemotherapy drug approved for cancer treatment.,CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C,36314.0
+190,Docetaxel,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,"Approved anticancer drug, often used in chemotherapy treatments.",CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O,148124.0
+191,Docetaxel (Trihydrate),"TUBB1, TUBB3, TUBB4B, TUBB4A, TUBB2A, TUBB2B",unclear,Microtubule inhibitor,yes,yes,"Approved cancer treatment, commonly used in chemotherapy.",CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O.O.O.O,148123.0
+192,Roxadustat,,inhibitor/antagonist,unclear,yes,yes,"Approved for anemia treatment in some countries, e.g., China, Japan.",CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3,11256664.0
+193,Thymol,TRPA1,activator/agonist,unclear,no,yes,Used in clinical trials as antiseptic and antifungal.,CC1=CC(=C(C=C1)C(C)C)O,6989.0
+194,Gemfibrozil,"PPARA, CYP2C9, CYP2C19, CYP2C8, CYP1A2",unclear,unclear,yes,yes,Approved for dyslipidemia treatment.,CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O,3463.0
+195,Vortioxetine,"SLC6A4, HTR3A, HTR7",unclear,unclear,yes,yes,Approved for major depressive disorder.,CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C,9966051.0
+196,OTS514,MAP3K8,inhibitor/antagonist,Other MAPK inhibitor,no,yes,Investigational drug in preclinical and early phase clinical trials.,CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN)O,67448836.0
+197,Pralsetinib,RET,inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for RET fusion-positive cancers.,CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC,129073603.0
+198,Menadione,,unclear,unclear,no,yes,"Used in trials; a vitamin K analog, not fully approved for human use.",CC1=CC(=O)C2=CC=CC=C2C1=O,4055.0
+199,Ciclopirox,,unclear,unclear,yes,yes,"Approved for antifungal use, primarily in nail and skin treatments.",CC1=CC(=O)N(C(=C1)C2CCCCC2)O,2749.0
+200,Methylthiouracil,,unclear,unclear,no,yes,"Used in research, not approved for human therapeutic use.",CC1=CC(=O)NC(=S)N1,667493.0
+201,Tolcapone,COMT,inhibitor/antagonist,unclear,yes,yes,"Used in Parkinson's treatment, subject to liver monitoring.",CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-],4659569.0
+202,Tolmetin,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for pain and inflammation.,CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O,5509.0
+203,Celecoxib,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Used for arthritis pain and inflammation; approved NSAID.,CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F,2662.0
+204,S-Adenosyl-L-methionine (disulfate tosylate),,unclear,unclear,yes,yes,Used as dietary supplement; approved in some countries for depression treatment.,CC1=CC=C(C=C1)S(=O)(=O)O.C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O.OS(=O)(=O)O.OS(=O)(=O)[O-],9875462.0
+205,Lapatinib ditosylate,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for use in breast cancer treatment.,CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O,11557040.0
+206,LY-2584702 (tosylate salt),RPS6KB1,inhibitor/antagonist,MTOR inhibitor,no,yes,Investigated in clinical trials for cancer treatment. Not approved for human use.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F,46205871.0
+207,Edoxaban (tosylate monohydrate),F10,inhibitor/antagonist,unclear,yes,yes,Approved as an anticoagulant for preventing stroke and blood clots.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O,25022378.0
+208,Lumateperone (tosylate),"HTR2A, DRD2",unclear,unclear,yes,yes,Approved for schizophrenia; marketed as Caplyta.,CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN2C3CCN(CC3C4=C2C1=CC=C4)CCCC(=O)C5=CC=C(C=C5)F,44241743.0
+209,Mozavaptan,AVPR2,inhibitor/antagonist,unclear,no,yes,In trials for conditions like hyponatremia but not approved for use.,CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C,119369.0
+210,Bexarotene,"RXRA, RXRB, RXRG",activator/agonist,Retinoic receptor agonist,yes,yes,Approved for treating cutaneous T-cell lymphoma.,CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(=O)O)C(CCC2(C)C)(C)C,82146.0
+211,Sulfatinib,"FLT1, KDR, FLT4, FGFR1, CSF1R",inhibitor/antagonist,Multi-TK inhibitor,no,yes,"Investigated in trials for neuroendocrine tumors, not yet approved for use.",CC1=CC2=C(N1)C=CC(=C2)OC3=NC(=NC=C3)NC4=CC=CC(=C4)CS(=O)(=O)NCCN(C)C,52920501.0
+212,Olanzapine,"HTR2A, HTR2C, DRD2, DRD4, ADRA1A, ADRA1B, ADRA1D, HTR6, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5",inhibitor/antagonist,unclear,yes,yes,Olanzapine is used in treatment of schizophrenia and bipolar disorder.,CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C,135398745.0
+213,AZD-7648,PRKDC,inhibitor/antagonist,DNA synthesis/repair inhibitor,no,yes,"Inhibitor studied for DNA repair, not yet approved for human use.",CC1=CC2=NC=NN2C=C1NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCOCC5,135151360.0
+214,Megestrol,,unclear,unclear,yes,yes,Used for appetite loss and weight gain in cancer/AIDS patients.,CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C,19090.0
+215,Omeprazole (sodium),,inhibitor/antagonist,unclear,yes,yes,Approved in salt form as acid reflux treatment.,CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+],12108541.0
+216,Omeprazole,,inhibitor/antagonist,unclear,yes,yes,Used as part of racemic mixture for acid-related conditions.,CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC,4594.0
+217,Fedratinib (hydrochloride hydrate),"JAK2, FLT3, RET",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for treatment of myelofibrosis.,CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4.O.Cl.Cl,67517580.0
+218,Meloxicam,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Meloxicam is an approved NSAID for pain and inflammation.,CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O,54677470.0
+219,Pyridoxine,,unclear,unclear,yes,yes,Vitamin B6; essential nutrient approved for various health conditions.,CC1=NC=C(C(=C1O)CO)CO,1054.0
+220,Pyridoxine (hydrochloride),,unclear,unclear,yes,yes,"Vitamin B6, approved for various medical conditions.",CC1=NC=C(C(=C1O)CO)CO.Cl,6019.0
+221,Ornidazole,,unclear,unclear,yes,yes,"Used for bacterial and protozoal infections, common in some countries.",CC1=NC=C(N1CC(CCl)O)[N+](=O)[O-],28061.0
+222,Raltitrexed,TYMS,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment as thymidylate synthase inhibitor.,CC1=NC2=C(C=C(C=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1,135400182.0
+223,BI-3406,"KRAS, SOS1",inhibitor/antagonist,RAS inhibitor,no,yes,"Investigational compound, clinical trials for KRAS-driven cancers.",CC1=NC2=CC(=C(C=C2C(=N1)NC(C)C3=CC(=CC(=C3)N)C(F)(F)F)OC4CCOC4)OC,138911318.0
+224,Triamcinolone,NR3C1,unclear,Glucocorticoid receptor agonist,yes,yes,Approved corticosteroid for various inflammatory and allergic conditions.,CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O,31307.0
+225,Drospirenone,,unclear,unclear,yes,yes,"Found in birth control, often combined with ethinyl estradiol.",CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C,68873.0
+226,Eplerenone,NR3C2,inhibitor/antagonist,unclear,yes,yes,Used to treat heart failure and hypertension.,CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC,443872.0
+227,Quinestrol,,unclear,unclear,yes,yes,Estrogen approved for use in menopausal therapy and contraceptives.,CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5,9046.0
+228,Estrone sulfate (potassium),,unclear,unclear,no,yes,Estrone sulfate used in hormone therapy; potassium salt not specifically approved.,CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[K+],23674502.0
+229,Finasteride,SRD5A2,inhibitor/antagonist,unclear,yes,yes,Used for benign prostatic hyperplasia and male pattern baldness.,CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C,57363.0
+230,Fulvestrant,ESR1,inhibitor/antagonist,unclear,yes,yes,Estrogen receptor antagonist used for hormone receptor-positive breast cancer.,CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F,104741.0
+231,Monocrotaline,"SLC22A1, SLC22A2",inhibitor/antagonist,unclear,no,no,"Toxic pyrrolizidine alkaloid, not approved for human use.",CC1C(=O)OC2CCN3C2C(=CC3)COC(=O)C(C1(C)O)(C)O,9415.0
+232,Ouabain (Octahydrate),,unclear,unclear,no,yes,Investigated for heart failure but not approved for human use.,CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O,6364534.0
+233,Rutin (trihydrate),,unclear,unclear,no,no,Commonly used in supplements; lacks regulatory approval as a drug.,CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O.O.O.O,16218542.0
+234,Hesperidin,,unclear,unclear,no,yes,"Studied for various health benefits, but not approved as a drug.",CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O,10621.0
+235,Digitoxin,,unclear,unclear,no,yes,"Clinical trials for certain conditions, but not FDA approved for human use.",CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O,441207.0
+236,Doxorubicin (hydrochloride),"TOP2A, TOP2B, TOP1",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Commonly used chemotherapy drug for several cancers.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl,443939.0
+237,Epirubicin (hydrochloride),TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in chemotherapies as single agent or in combination treatments.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl,65348.0
+238,Idarubicin (hydrochloride),TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in acute myeloid leukemia treatment.,CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl,636362.0
+239,Plicamycin,"SP1, GSTM2",inhibitor/antagonist,unclear,yes,yes,Plicamycin is used to treat testicular cancer and hypercalcemia.,CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O,163659.0
+240,Rifaximin,,unclear,unclear,yes,yes,Approved for treatment of IBS and hepatic encephalopathy.,CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C,6436173.0
+241,Doxycycline (monohydrate),"MMP7, MMP8, MMP9, MMP13, MMP14",inhibitor/antagonist,unclear,yes,yes,Approved antibiotic for bacterial infections.,CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O,54684461.0
+242,Fusidic acid,,inhibitor/antagonist,unclear,yes,yes,Used topically and orally for bacterial infections.,CC1C2CCC3(C(C2(CCC1O)C)C(CC4C3(CC(C4=C(CCC=C(C)C)C(=O)O)OC(=O)C)C)O)C,3000226.0
+243,Ipatasertib,"AKT1, AKT2, AKT3",inhibitor/antagonist,PI3K/AKT inhibitor,no,yes,"Investigational cancer drug, not approved for human use.",CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O,24788740.0
+244,Medroxyprogesterone acetate,PGR,unclear,unclear,yes,yes,Approved as a contraceptive and for hormone therapy.,CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C,6279.0
+245,Methylprednisolone succinate,NR3C1,unclear,Glucocorticoid receptor agonist,yes,yes,Corticosteroid; approved for reducing inflammation in various conditions.,CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O,16923.0
+246,Dexamethasone,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,Commonly used glucocorticoid for inflammation and immune response regulation.,CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C,5743.0
+247,Dihydroartemisinin,,unclear,unclear,yes,yes,"Active metabolite of artemisinin, approved for malaria treatment.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C,3000518.0
+248,Artesunate,,inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,"Used for severe malaria, often partnered with other antimalarial drugs.",CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C,6917864.0
+249,Artemether,,unclear,unclear,yes,yes,Artemether is used in combination with lumefantrine to treat malaria.,CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C,68911.0
+250,Rapamycin,"MTOR, FKBP1A",inhibitor/antagonist,MTOR inhibitor,yes,yes,Approved mainly for organ transplantation and cancer treatment.,CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC,5284616.0
+251,Temsirolimus,MTOR,inhibitor/antagonist,MTOR inhibitor,yes,yes,Approved for treating renal cell carcinoma.,CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC,6918289.0
+252,Everolimus,"MTOR, FKBP1A",inhibitor/antagonist,MTOR inhibitor,yes,yes,"Approved for certain types of cancer, organ transplantation, and tuberous sclerosis.",CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC,6442177.0
+253,Tofacitinib,"JAK1, JAK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for rheumatoid arthritis and other conditions.,CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N,9926791.0
+254,Tofacitinib (citrate),"JAK1, JAK2, JAK3",inhibitor/antagonist,JAK/STAT inhibitor,yes,yes,Approved for rheumatoid arthritis and other conditions.,CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O,10174505.0
+255,Sonidegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for basal cell carcinoma treatment.,CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F,24775005.0
+256,AZD-8055,MTOR,inhibitor/antagonist,MTOR inhibitor,no,yes,Investigational drug; explored in trials mainly for cancer treatment.,CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C,25262965.0
+257,Elimusertib hydrochloride,ATR,inhibitor/antagonist,unclear,no,yes,Tested in trials for cancer but not approved for human use.,CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C,118869362.0
+258,Clobetasol propionate,"CYP3A5,CYP3A4",inhibitor/antagonist,unclear,yes,yes,It's a potent corticosteroid for skin conditions.,CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl,32798.0
+259,Betamethasone dipropionate,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,A corticosteroid approved and used in topical formulations for inflammation.,CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)OC(=O)CC,21800.0
+260,Posaconazole,,unclear,unclear,yes,yes,Broad-spectrum antifungal approved for human use.,CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F,468595.0
+261,Pravastatin (sodium),HMGCR,inhibitor/antagonist,unclear,yes,yes,Approved as a cholesterol-lowering agent.,CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O.[Na+],16759173.0
+262,Ivermectin,,unclear,unclear,yes,yes,Approved for infections in humans and animals.,CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C,6321424.0
+263,Topotecan (hydrochloride),TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,"Approved for treating ovarian, small cell lung, and cervical cancer.",CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl,60699.0
+264,Vinblastine (sulfate),,inhibitor/antagonist,Microtubule inhibitor,yes,yes,"Used in cancer treatment, notably Hodgkin's lymphoma.",CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,5388983.0
+265,vincristine,,inhibitor/antagonist,Microtubule inhibitor,yes,yes,Used in chemotherapy for various cancers.,CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,249332.0
+266,Indacaterol (maleate),ADRB2,activator/agonist,Adrenoceptor agonist,yes,yes,Approved for COPD as a long-acting bronchodilator.,CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O,9827599.0
+267,Pimitespib,"HSP90AA1, HSP90AB1",inhibitor/antagonist,unclear,no,yes,Investigated in trials for cancer; not approved for human use yet.,CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C,67501411.0
+268,Irinotecan,TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,"Used in cancer treatment, especially for colorectal cancer.",CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7,60838.0
+269,Irinotecan (hydrochloride),TOP1,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved for cancer treatment as a topoisomerase inhibitor.,CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl,74990.0
+270,Dinaciclib,"CDK1, CDK2, CDK5, CDK9",inhibitor/antagonist,CDK inhibitor,no,yes,Investigated in trials; not yet approved for human use.,CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO,46926350.0
+271,Pioglitazone,PPARG,activator/agonist,unclear,yes,yes,Approved for type 2 diabetes treatment.,CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3,4829.0
+272,Volasertib,"PLK1, PLK2, PLK3",inhibitor/antagonist,unclear,no,yes,"Investigated for cancer treatment, not approved for human use.",CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C,10461508.0
+273,Cyclosporin A,"PPP3CA, PPP3CB, PPP3CC",inhibitor/antagonist,unclear,yes,yes,Immunosuppressant approved for organ transplant patients.,CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C,5284373.0
+274,Erythromycin,,inhibitor/antagonist,unclear,yes,yes,Antibiotic used to treat infections; approved for human use.,CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O,12560.0
+275,Azithromycin (hydrate),,unclear,unclear,yes,yes,Approved as an antibiotic for bacterial infections.,CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O,3033819.0
+276,Perindopril (erbumine),"STAT3, ACE",inhibitor/antagonist,unclear,yes,yes,Approved ACE inhibitor for hypertension and heart failure.,CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N,441313.0
+277,Sildenafil,PDE5A,inhibitor/antagonist,unclear,yes,yes,Approved for erectile dysfunction and pulmonary arterial hypertension.,CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C,135398744.0
+278,Budesonide,NR3C1,activator/agonist,Glucocorticoid receptor agonist,yes,yes,"Used for asthma, Crohn's disease, ulcerative colitis.",CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C,5281004.0
+279,Hexylresorcinol,,inhibitor/antagonist,unclear,yes,yes,Used in throat lozenges and skin creams for antiseptic purposes.,CCCCCCC1=C(C=C(C=C1)O)O,3610.0
+280,Oleic acid,,activator/agonist,unclear,yes,yes,"Used in food, cosmetics, and as an excipient in pharmaceuticals.",CCCCCCCCC=CCCCCCCCC(=O)O,445639.0
+281,Fingolimod (hydrochloride),PAK1,unclear,unclear,yes,yes,Approved for multiple sclerosis treatment.,CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl,107969.0
+282,Daptomycin,,unclear,unclear,yes,yes,Approved as an antibiotic for skin infections.,CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C,21585658.0
+283,Orlistat,,inhibitor/antagonist,unclear,yes,yes,Used to treat obesity by preventing fat absorption.,CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O,3034010.0
+284,Levobupivacaine (hydrochloride),SCN5A,inhibitor/antagonist,unclear,yes,yes,Approved as an enantiomer of bupivacaine for anesthetic use.,CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl,117965.0
+285,Proglumide,"CCKBR, CCKAR",inhibitor/antagonist,unclear,no,yes,"Proglumide investigated for gastrointestinal use, not widely approved for humans.",CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1,4922.0
+286,Ropivacaine (hydrochloride monohydrate),,inhibitor/antagonist,unclear,yes,yes,A local anesthetic used in surgeries and pain management.,CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl,6918111.0
+287,Macitentan,"EDNRA, EDNRB",inhibitor/antagonist,unclear,yes,yes,Approved for pulmonary arterial hypertension treatment.,CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br,16004692.0
+288,Vemurafenib,BRAF,inhibitor/antagonist,RAF inhibitor,yes,yes,Approved for treating BRAF V600E mutation-positive melanoma.,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F,42611257.0
+289,Lidocaine (hydrochloride),"MAP2K1, MAPK1, NFKB1",unclear,unclear,yes,yes,Lidocaine hydrochloride is approved as a local anesthetic.,CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl,6314.0
+290,Sunitinib,"KDR, PDGFRB",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved anticancer drug used for renal cell carcinoma and gastrointestinal stromal tumors.,CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C,5329102.0
+291,Procainamide (hydrochloride),DNMT1,inhibitor/antagonist,DNA methyltransferase inhibitor,yes,yes,Used for arrhythmias; often as its hydrochloride salt form.,CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl,66068.0
+292,Lucanthone,,inhibitor/antagonist,unclear,no,yes,"Investigated for cancer treatment, not approved for human use.",CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O,10180.0
+293,RMC-6236,KRAS,inhibitor/antagonist,RAS inhibitor,no,yes,"Investigated as a potential cancer treatment, but not approved for human use.",CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C)C(C)OC)(C)C)NC(=O)C8CC8C,164726578.0
+294,Pemigatinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for treating cholangiocarcinoma.,CCN1C2=C3C=C(NC3=NC=C2CN(C1=O)C4=C(C(=CC(=C4F)OC)OC)F)CN5CCOCC5,86705695.0
+295,Infigratinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Used for bile duct cancer treatment.,CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl,53235510.0
+296,NG25,"MAP4K2, MAP3K7, LYN, ABL1, ABL2, FER, SRC, EPHA2, EPHB2, EPHB4, ZAK, ZKSCAN1, RAF1",inhibitor/antagonist,Other MAPK inhibitor,no,yes,"NG25 is in preclinical stages, not approved for humans.",CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F,53340664.0
+297,Abemaciclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,"FDA approved for HR-positive, HER2-negative breast cancer.",CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F,46220502.0
+298,Bimatoprost,,unclear,unclear,yes,yes,Approved for treating glaucoma and cosmetic lash applications.,CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O,5311027.0
+299,Dorzolamide (hydrochloride),CA2,inhibitor/antagonist,unclear,yes,yes,Approved for glaucoma treatment.,CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl,6918132.0
+300,Tazarotene,"RARA, RARB, RARG",activator/agonist,Retinoic receptor agonist,yes,yes,Topical retinoid approved for psoriasis and acne treatment.,CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C,5381.0
+301,Neratinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for breast cancer treatment.,CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C,9915743.0
+302,Neratinib (maleate),"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for HER2-positive breast cancer treatment.,CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C.C(=CC(=O)O)C(=O)O,67307512.0
+303,Dapagliflozin,SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for diabetes treatment.,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl,9887712.0
+304,"Dapagliflozin ((2S)-1,2-propanediol, hydrate)",SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved SGLT2 inhibitor for type 2 diabetes and heart failure.,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CC(CO)O.O,24906252.0
+305,Auranofin,"TXNRD1, TXNRD2",inhibitor/antagonist,unclear,yes,yes,Approved for rheumatoid arthritis treatment since 1985.,CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+],24199313.0
+306,TAK-901,AURKB,inhibitor/antagonist,unclear,no,yes,Investigational cancer drug; not approved for human use yet.,CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C,16124208.0
+307,Loperamide (hydrochloride),,unclear,unclear,yes,yes,"Approved for diarrhea treatment, limited CNS penetration due to P-gp substrate.",CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl,71420.0
+308,Ribociclib,"CDK4, CDK6",inhibitor/antagonist,CDK inhibitor,yes,yes,Approved for human use in combination with letrozole for breast cancer.,CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5,44631912.0
+309,Altretamine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Used as a chemotherapy drug for ovarian cancer.,CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C,2123.0
+310,Demeclocycline,,inhibitor/antagonist,unclear,yes,yes,"Used off-label for SIADH, primarily an antibiotic.",CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O,54680690.0
+311,Afatinib,"EGFR, ERBB2",inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,"Approved for treatment of certain cancers, such as non-small cell lung cancer.",CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4,10184653.0
+312,Relugolix,GNRHR,inhibitor/antagonist,unclear,yes,yes,Approved for prostate cancer and uterine fibroids treatment.,CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC,10348973.0
+313,Citalopram (hydrobromide),SLC6A4,inhibitor/antagonist,unclear,yes,yes,Approved antidepressant; selective serotonin reuptake inhibitor (SSRI).,CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br,77995.0
+314,Almonertinib (hydrochloride),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved in China for non-small cell lung cancer.,CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.Cl,137319707.0
+315,Almonertinib (mesylate),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved in China for NSCLC treatment.,CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O,162368359.0
+316,Diphenhydramine,HRH1,inhibitor/antagonist,unclear,yes,yes,"Approved antihistamine, used for allergies and as a sleep aid.",CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2,3100.0
+317,ML264,KLF5,inhibitor/antagonist,unclear,no,no,No clinical trials found on clinicaltrials.gov.,CN(C1CCS(=O)(=O)CC1)C(=O)CNC(=O)C=CC2=CC(=CC=C2)Cl,51003603.0
+318,Methotrexate,DHFR,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Widely used for cancer and autoimmune diseases treatments.,CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O,126941.0
+319,Ivabradine (hydrochloride),HCN4,inhibitor/antagonist,unclear,yes,yes,"Approved for human use, primarily for heart failure and angina management.",CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl,3045381.0
+320,Rosiglitazone,"PPARG, TRPC5, TRPM3",unclear,unclear,yes,yes,Approved for diabetes; risk of heart failure in some patients.,CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3,77999.0
+321,Piroxicam,"PTGS1, PTGS2",inhibitor/antagonist,Cyclooxygenase inhibitor,yes,yes,Approved NSAID for arthritis and pain relief.,CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3,54676228.0
+322,c-Kit-IN-1,"KIT, MET, KDR, PDGFRA, PDGFRB",inhibitor/antagonist,Multi-TK inhibitor,no,no,Experimental compound with no clinical trials reported.,CN1C=C(C=N1)C2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)F,46208890.0
+323,CP21R7,"GSK3B, PRKCA",inhibitor/antagonist,GSK3 inhibitor,no,yes,Investigational drug in research for neurodegenerative diseases.,CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CC(=CC=C4)N,5327711.0
+324,9-ING-41,GSK3B,inhibitor/antagonist,GSK3 inhibitor,no,yes,"Investigational drug, not approved for human use yet.",CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F,44582816.0
+325,Binimetinib,"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,no,yes,"Investigated for cancer, not approved for human use.",CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO,10288191.0
+326,TAK-733,MAP2K1,inhibitor/antagonist,MEK inhibitor,no,yes,Investigated as anti-cancer MEK inhibitor; not approved for human use.,CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O,24963252.0
+327,Bendamustine,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in leukemia and lymphoma treatment.,CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O,65628.0
+328,Benztropine (mesylate),,inhibitor/antagonist,unclear,yes,yes,Used for Parkinson's disease and drug-induced extrapyramidal symptoms.,CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)O,238053.0
+329,Tadalafil,PDE5A,inhibitor/antagonist,unclear,yes,yes,Used for erectile dysfunction and pulmonary arterial hypertension.,CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36,110635.0
+330,Vandetanib,"EGFR, KDR",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for use in medullary thyroid cancer.,CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC,3081361.0
+331,Glasdegib,SMO,inhibitor/antagonist,Sonic inhibitor,yes,yes,Glasdegib is approved for acute myeloid leukemia.,CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N,25166913.0
+332,Isocorydine,,unclear,unclear,no,no,No clinical trials found on clinicaltrials.gov,CN1CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)OC)OC,10143.0
+333,Berbamine,CACNA1C,inhibitor/antagonist,unclear,no,no,"Studied for cancer treatment, but not approved for human use yet.",CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC,275182.0
+334,Berbamine (dihydrochloride),,inhibitor/antagonist,unclear,no,no,No clinical trial data found on clinicaltrials.gov.,CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl,16217067.0
+335,Cepharanthine,"CYP3A4, CYP2E1, CYP2C9",inhibitor/antagonist,unclear,no,yes,Studied for cancer and viral diseases; not approved for human use yet.,CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3,10206.0
+336,Sinomenine,OPRM1,unclear,unclear,no,yes,Used in trials for pain and arthritis.,CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC,5459308.0
+337,Adagrasib,KRAS,inhibitor/antagonist,RAS inhibitor,yes,yes,Approved for treating KRAS G12C-mutated non-small cell lung cancer.,CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(C6)CC#N)C(=O)C(=C)F,138611145.0
+338,LB-100,"PPP2CA, PPP2CB",inhibitor/antagonist,unclear,no,yes,LB-100 is in clinical trials for cancer treatment.,CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3,3578572.0
+339,Entrectinib,"NTRK1, NTRK2, NTRK3, ROS1, ALK",inhibitor/antagonist,Other TK inhibitor,yes,yes,Approved for use in cancers with NTRK gene fusions.,CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6,25141092.0
+340,AZD2858,"GSK3B, GSK3A",inhibitor/antagonist,GSK3 inhibitor,no,no,Investigated in rodent models.,CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N,10138980.0
+341,Capmatinib,MET,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for NSCLC treatment by FDA in May 2020.,CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F,25145656.0
+342,Apalutamide,AR,inhibitor/antagonist,Androgen receptor antagonist,yes,yes,Used for non-metastatic castration-resistant prostate cancer.,CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F,24872560.0
+343,Regorafenib,"BRAF, FLT1, FLT4, KDR, KIT, PDGFRB, RAF1, RET, TEK",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,"Used for metastatic colorectal cancer, GIST, HCC.",CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F,11167602.0
+344,Phenylephrine (hydrochloride),"ADRA1A, ADRA1B, ADRA1D",activator/agonist,Adrenoceptor agonist,yes,yes,Widely used as a decongestant and in eye drops.,CNCC(C1=CC(=CC=C1)O)O.Cl,5284443.0
+345,Rucaparib (phosphate),"PARP1, PARP2, PARP3",inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Approved as a cancer therapy PARP inhibitor.,CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O,9931953.0
+346,Clopidogrel,P2RY12,inhibitor/antagonist,unclear,yes,yes,"Antiplatelet drug approved for preventing stroke, heart attack in high-risk patients.",COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3,60606.0
+347,Dimethyl fumarate,NFE2L2,activator/agonist,unclear,yes,yes,Approved for multiple sclerosis treatment.,COC(=O)C=CC(=O)OC,637568.0
+348,Methyl aminolevulinate (hydrochloride),,unclear,unclear,yes,yes,Used in photodynamic therapy for actinic keratosis.,COC(=O)CCC(=O)CN.Cl,157921.0
+349,Mebendazole,"TUBA1A, TUBA1B, TUBA1C, TUBB, TUBB1, TUBB2A, TUBB3, TUBB4A, TUBB4B, TUBB6",inhibitor/antagonist,Microtubule inhibitor,yes,yes,Approved for treating parasitic worm infestations.,COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3,4030.0
+350,Tranilast,"PLA2G2A, EGR1",inhibitor/antagonist,unclear,yes,yes,Approved for asthma and allergic disorders in some countries.,COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC,5282230.0
+351,Gefitinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for non-small cell lung cancer.,COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4,123631.0
+352,Simotinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,no,yes,"Investigated in trials, but not approved for human use.",COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCN4CC5(CC5)C6(C4)OCCO6,16735117.0
+353,Bergenin,,unclear,unclear,no,yes,Investigated for anti-inflammatory and antiulcer effects in clinical trials.,COC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O,66065.0
+354,Ferulic acid,"FGFR1, FGFR2",inhibitor/antagonist,Other TK inhibitor,no,yes,Used in skincare; not an FDA-approved drug.,COC1=C(C=CC(=C1)C=CC(=O)O)O,445858.0
+355,Amsacrine,TOP2A,inhibitor/antagonist,DNA synthesis/repair inhibitor,yes,yes,Used in the treatment of acute leukemias.,COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42,2179.0
+356,Palmatine (chloride),"IDO1, WNV NS2B-NS3",inhibitor/antagonist,unclear,no,yes,Used in some traditional medicine; lacks formal approval for human use.,COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-],73442.0
+357,Berberine (chloride hydrate),,unclear,unclear,no,yes,"Used in trials for metabolic/heart diseases, not FDA-approved.",COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.O.[Cl-],155074.0
+358,Futibatinib,"FGFR1, FGFR2, FGFR3, FGFR4",inhibitor/antagonist,Other TK inhibitor,yes,yes,Used for cholangiocarcinoma; FDA approved.,COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)C4CCN(C4)C(=O)C=C)OC,71621331.0
+359,Tubulin inhibitor 6,,inhibitor/antagonist,Microtubule inhibitor,no,no,No available data on human use or clinical trials.,COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl,2359994.0
+360,Anethole trithione,,unclear,unclear,no,yes,Investigated for dry mouth in clinical trials.,COC1=CC=C(C=C1)C2=CC(=S)SS2,2194.0
+361,Cabozantinib (S-malate),"MET, KDR, AXL",inhibitor/antagonist,Multi-TK inhibitor,yes,yes,Approved for medullary thyroid cancer and renal cell carcinoma.,COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O,25102846.0
+362,Fluvoxamine,SLC6A4,unclear,unclear,yes,yes,SSRI approved for treating OCD and depression.,COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F,5324346.0
+363,Fluvoxamine (maleate),,inhibitor/antagonist,unclear,yes,yes,Approved for treating OCD and depression-related disorders in humans.,COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F.C(=CC(=O)O)C(=O)O,9560989.0
+364,Erlotinib,EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for human use for non-small cell lung cancer.,COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC,176870.0
+365,Belzutifan,EPAS1,inhibitor/antagonist,unclear,yes,yes,Approved for treating certain cancer types.,CS(=O)(=O)C1=C2C(C(C(C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O,117947097.0
+366,Vismodegib,"SMO, ABCB1, ABCG2",inhibitor/antagonist,Sonic inhibitor,yes,yes,Approved for treating basal cell carcinoma.,CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl,24776445.0
+367,Nimesulide,PTGS2,inhibitor/antagonist,Cyclooxygenase inhibitor,no,yes,Withdrawn in some countries due to safety concerns; not FDA-approved.,CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2,4495.0
+368,Nafamostat (mesylate),,inhibitor/antagonist,unclear,yes,yes,"Approved in some countries, often used as anticoagulant.",CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N,5311180.0
+369,Busulfan,,unclear,DNA synthesis/repair inhibitor,yes,yes,Approved for use in bone marrow transplantation.,CS(=O)(=O)OCCCCOS(=O)(=O)C,2478.0
+370,18β-Glycyrrhetinic acid,,unclear,unclear,no,yes,"Used in cosmetics, derived from licorice root, no approval for human drugs.",C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O,10114.0
+371,Trametinib (DMSO_TF solvate),"MAP2K1, MAP2K2",inhibitor/antagonist,MEK inhibitor,yes,yes,"Approved for use in cancer treatment (e.g., melanoma).", CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5  ,11707110.0
+372,Sacubitril/Valsartan,AGTR1,inhibitor/antagonist,unclear,yes,yes,"Combination drug known as Entresto, used for heart failure treatment.",,
+373,Pitavastatin (Calcium),HMGCR,inhibitor/antagonist,unclear,yes,yes,"Approved for lowering cholesterol, part of statins class of drugs.", C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2],5282451.0
+374,Verteporfin,YAP1,inhibitor/antagonist,unclear,yes,yes,Used in photodynamic therapy for macular degeneration.,,
+375,Quinidine (15% dihydroquinidine),KCNH2,inhibitor/antagonist,unclear,yes,yes,Approved for arrhythmias as part of quinine alkaloids.,COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O  ,441074.0
+376,Canagliflozin (hemihydrate),SLC5A2,inhibitor/antagonist,Glucose transporter inhibitor,yes,yes,Approved for type 2 diabetes.,CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.O,24997615.0
+377,Osimertinib (mesylate),EGFR,inhibitor/antagonist,EGFR/ERBB inhibitor,yes,yes,Approved for non-small cell lung cancer treatment.,CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O  ,78357807.0
+378,γ-Oryzanol,,inhibitor/antagonist,DNA methyltransferase inhibitor,no,yes,Used in supplements; limited human data.,C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/C6=CC(=C(C=C6)O)OC)C)C,5282164.0

data/drugs_organs_approved.csv

@@ -0,0 +1,377 @@
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data/indication_to_organ_mapping_all.tsv

@@ -0,0 +1,1013 @@
+indication_mesh_term	organ
+Neoplasms	
+Breast Neoplasms	Breast
+Pancreatic Neoplasms	Pancreas
+Colorectal Neoplasms	Bowel
+Inflammation	
+Carcinoma, Non-Small-Cell Lung	Lung
+Prostatic Neoplasms	
+Ovarian Neoplasms	Ovary/Fallopian Tube
+Brain Neoplasms	CNS/Brain
+Glioblastoma	CNS/Brain
+Medulloblastoma	CNS/Brain
+Melanoma	Skin
+COVID-19	Lung
+Leukemia, Myeloid, Acute	
+Arthritis, Rheumatoid	Skin
+Hematologic Neoplasms	
+Nervous System Diseases	
+Alzheimer Disease	CNS/Brain
+Multiple Myeloma	
+Liver Neoplasms	Liver
+Psoriasis	Skin
+Head and Neck Neoplasms	
+Kidney Neoplasms	Kidney
+Multiple Sclerosis	CNS/Brain
+Autoimmune Diseases	
+Lung Neoplasms	Lung
+Asthma	Lung
+Lymphoma	
+Diabetes Mellitus, Type 2	
+Parkinson Disease	CNS/Brain
+Inflammatory Bowel Diseases	Bowel
+Non-alcoholic Fatty Liver Disease	Liver
+Stomach Neoplasms	Esophagus/Stomach
+Urinary Bladder Neoplasms	Bladder/Urinary Tract
+Myelodysplastic Syndromes	
+Neuralgia	Peripheral Nervous System
+Lymphoma, Non-Hodgkin	
+Pulmonary Disease, Chronic Obstructive	Lung
+Nociceptive Pain	
+Brain Ischemia	CNS/Brain
+Stroke	CNS/Brain
+Idiopathic Pulmonary Fibrosis	Lung
+Diabetes Mellitus	
+Cardiovascular Diseases	
+Colitis, Ulcerative	Bowel
+Obesity	
+Immune System Diseases	
+Leukemia, Lymphocytic, Chronic, B-Cell	
+Sarcoma	
+Crohn Disease	Bowel
+Precursor Cell Lymphoblastic Leukemia-Lymphoma	
+Heart Failure	
+Graft vs Host Disease	
+Dermatitis, Atopic	Skin
+Esophageal Neoplasms	Esophagus/Stomach
+Small Cell Lung Carcinoma	Lung
+Atherosclerosis	
+Leukemia	
+Lupus Erythematosus, Systemic	Skin
+Respiratory Distress Syndrome	Lung
+Myocardial Infarction	
+Amyotrophic Lateral Sclerosis	CNS/Brain
+Eye Diseases	
+Endometrial Neoplasms	Uterus
+Arthritis	
+Bile Duct Neoplasms	
+Peritoneal Neoplasms	
+Lymphoma, Large B-Cell, Diffuse	
+Depression	
+Schizophrenia	
+Hypertension, Pulmonary	Lung
+Lymphoma, B-Cell	
+Mesothelioma	
+Diabetic Retinopathy	
+Fallopian Tube Neoplasms	Ovary/Fallopian Tube
+Liver Cirrhosis	Liver
+Osteoarthritis	
+HIV Infections	
+Diabetic Nephropathies	Kidney
+Brain Injuries, Traumatic	CNS/Brain
+Anxiety Disorders	
+Diabetes Mellitus, Type 1	
+Wound Healing	
+Uterine Cervical Neoplasms	Cervix
+Scleroderma, Systemic	Skin
+Leukemia, Myelogenous, Chronic, BCR-ABL Positive	
+Scleroderma, Diffuse	Skin
+Scleroderma, Limited	Skin
+Wet Macular Degeneration	
+Glaucoma	
+Musculoskeletal Pain	
+Diabetic Neuropathies	Peripheral Nervous System
+Thyroid Neoplasms	
+Depressive Disorder, Major	
+Epilepsy	CNS/Brain
+Kidney Failure, Chronic	Kidney
+Huntington Disease	CNS/Brain
+Lymphoma, Mantle-Cell	
+Hyperlipidemias	
+Macular Edema	
+Osteoporosis	
+Infections	
+Sepsis	
+Dry Eye Syndromes	
+Neoplasms, Squamous Cell	
+Neuroblastoma	
+Hypertension	
+Migraine Disorders	CNS/Brain
+Hodgkin Disease	
+Irritable Bowel Syndrome	Bowel
+Cytokine Release Syndrome	
+Eczema	Skin
+Spinal Cord Injuries	CNS/Brain
+Carcinoma, Neuroendocrine	
+Lymphoma, T-Cell	
+Osteosarcoma	
+Skin Diseases	Skin
+Thrombosis	
+Lymphoma, Follicular	
+Diabetes Complications	
+Peripheral Vascular Diseases	
+Cystic Fibrosis	
+Pneumonia	Lung
+Hepatitis C	Liver
+Primary Myelofibrosis	
+Uveitis	
+Geographic Atrophy	
+Ischemia	
+Pain, Postoperative	
+Gastrointestinal Stromal Tumors	Bowel
+Cachexia	
+Acne Vulgaris	Skin
+Bone Neoplasms	
+Hypercholesterolemia	
+Psychotic Disorders	
+Leukemia, Myelomonocytic, Chronic	
+Dementia	CNS/Brain
+Hepatitis B	Liver
+Sarcoma, Ewing	
+Multiple Sclerosis, Relapsing-Remitting	CNS/Brain
+Blood Coagulation Disorders	
+Coronary Restenosis	
+Cancer Pain	
+Anemia, Sickle Cell	
+Hypersensitivity	
+Sjogren's Syndrome	Skin
+Lymphoma, T-Cell, Peripheral	
+Rhinitis, Allergic	Lung
+Alcoholism	
+Anemia	
+Surgical Procedures, Operative	
+Muscular Dystrophy, Duchenne	CNS/Brain
+Pruritus	Skin
+Arthritis, Psoriatic	Skin
+Lymphoma, T-Cell, Cutaneous	Skin
+Multiple Sclerosis, Chronic Progressive	CNS/Brain
+Bipolar Disorder	
+Waldenstrom Macroglobulinemia	
+Urethral Neoplasms	Bladder/Urinary Tract
+Influenza, Human	Lung
+Diabetic Foot	Skin
+Urinary Bladder, Overactive	Bladder/Urinary Tract
+Fibromyalgia	CNS/Brain
+Liver Cirrhosis, Biliary	Liver
+Polycythemia Vera	
+Urinary Incontinence	Bladder/Urinary Tract
+Neuroendocrine Tumors	
+Angina Pectoris	
+Atrial Fibrillation	
+Attention Deficit Disorder with Hyperactivity	
+Sleep Wake Disorders	CNS/Brain
+Neuralgia, Postherpetic	Peripheral Nervous System
+Conjunctivitis, Allergic	
+Retinitis Pigmentosa	
+Tobacco Use Disorder	
+Endometriosis	Uterus
+Spondylitis, Ankylosing	
+Hypertriglyceridemia	
+Adrenal Gland Neoplasms	Kidney
+Nausea	
+Vomiting	
+Epilepsies, Partial	CNS/Brain
+Lymphoma, B-Cell, Marginal Zone	
+Rhabdomyosarcoma	
+Acute Coronary Syndrome	
+Alopecia	Skin
+Nasopharyngeal Neoplasms	
+Psychomotor Agitation	CNS/Brain
+Thrombocytopenia	
+Rhinitis, Allergic, Seasonal	Lung
+Sleep Initiation and Maintenance Disorders	CNS/Brain
+Vasculitis	
+Hidradenitis Suppurativa	Skin
+Gout	
+Menopause	
+Myasthenia Gravis	
+Thalassemia	
+Carcinoma, Merkel Cell	
+Cocaine-Related Disorders	
+Erectile Dysfunction	
+Neoplasms, Basal Cell	Skin
+Dyskinesia, Drug-Induced	Skin
+Glomerulonephritis, IGA	Kidney
+Opioid-Related Disorders	
+Prostatic Hyperplasia	
+Retinal Diseases	
+Rosacea	Skin
+Lewy Body Disease	CNS/Brain
+Cough	Lung
+Tuberculosis	
+Alopecia Areata	Skin
+Apnea	Lung
+Sarcoma, Kaposi	
+Thrombocytosis	
+Keratosis, Actinic	Skin
+Arthritis, Juvenile	Skin
+Contraception	
+Encephalomyocarditis virus	
+Mastocytosis	
+Postoperative Complications	
+Retinal Vein Occlusion	
+Venous Thrombosis	
+Papillomavirus Infections	
+Corneal Injuries	CNS/Brain
+Anus Neoplasms	Bowel
+Colitis	Bowel
+Lennox Gastaut Syndrome	CNS/Brain
+Prader-Willi Syndrome	CNS/Brain
+Sexual Dysfunction, Physiological	
+Purpura, Thrombocytopenic, Idiopathic	
+Sexual Dysfunctions, Psychological	
+Constipation	
+Gastroesophageal Reflux	Esophagus/Stomach
+Urticaria	Skin
+Gastroparesis	
+Behcet Syndrome	Skin
+Dyspepsia	
+Epidermolysis Bullosa	Skin
+Epilepsies, Myoclonic	CNS/Brain
+Hypotension	
+Muscular Atrophy, Spinal	CNS/Brain
+Radiation Injuries	
+Anemia, Hemolytic, Autoimmune	
+Neuromyelitis Optica	CNS/Brain
+Neutropenia	
+Binge-Eating Disorder	
+Eosinophilic Esophagitis	Esophagus/Stomach
+Burns	
+Lipodystrophy	Skin
+Pemphigus	Skin
+Respiratory Tract Infections	Lung
+Vitiligo	Skin
+Ileus	Bowel
+Anesthesia	
+Angina, Unstable	
+Bacterial Infections	
+Bronchiolitis Obliterans	Lung
+Infertility, Female	
+Menstruation Disturbances	
+Muscle Spasticity	CNS/Brain
+Obsessive-Compulsive Disorder	
+Spinocerebellar Ataxias	CNS/Brain
+Pituitary ACTH Hypersecretion	CNS/Brain
+Anorexia	
+Emphysema	Lung
+Epilepsy, Absence	CNS/Brain
+Fever	
+Friedreich Ataxia	CNS/Brain
+Hyperlipoproteinemia Type II	
+Leishmaniasis	Skin
+Leukemia, Hairy Cell	
+Sinusitis	Lung
+Panic Disorder	
+Lymphoma, Large-Cell, Anaplastic	
+Sleep Disorders, Circadian Rhythm	CNS/Brain
+Severe Acute Respiratory Syndrome	Lung
+Cataract	
+Epilepsy, Generalized	CNS/Brain
+Hemoglobinuria, Paroxysmal	
+Hemophilia A	
+Leiomyoma	Uterus
+Myeloproliferative Disorders	
+Pulmonary Embolism	Lung
+Status Epilepticus	CNS/Brain
+Tuberous Sclerosis	
+Hematopoietic Stem Cell Mobilization	
+Hemophilia B	
+Common Cold	Lung
+Hemolytic-Uremic Syndrome	
+Hemorrhage	
+Myopia	
+Narcolepsy	CNS/Brain
+Nasal Polyps	Lung
+Neuronal Ceroid-Lipofuscinoses	CNS/Brain
+Polycystic Ovary Syndrome	Ovary/Fallopian Tube
+Prurigo	Skin
+Spasms, Infantile	CNS/Brain
+Angioedemas, Hereditary	Skin
+Immunoglobulin Light-chain Amyloidosis	
+Ascites	
+Coronary Thrombosis	
+Hepatitis D	Liver
+Hepatitis, Viral, Human	Liver
+Restless Legs Syndrome	CNS/Brain
+Dermatitis, Seborrheic	Skin
+Ulcer	
+Hyperphosphatemia	
+Drug-Related Side Effects and Adverse Reactions	
+Opioid-Induced Constipation	
+Adrenoleukodystrophy	CNS/Brain
+Dwarfism, Pituitary	CNS/Brain
+Dysmenorrhea	
+Obstetric Labor, Premature	
+Nephritis, Hereditary	Kidney
+Prostatitis	
+Shock, Traumatic	
+Acromegaly	CNS/Brain
+Amyloidosis	
+Anemia, Aplastic	
+Anthrax	
+Cluster Headache	CNS/Brain
+Epilepsy, Tonic-Clonic	CNS/Brain
+Glycogen Storage Disease Type II	CNS/Brain
+Hypoglycemia	
+Hypogonadism	
+Ichthyosis	Skin
+Leprosy	
+Lymphoproliferative Disorders	
+Neurofibromatosis 1	
+Rhinitis, Allergic, Perennial	Lung
+Stomach Ulcer	Esophagus/Stomach
+Bronchitis, Chronic	Lung
+Dyslipidemias	
+Leber Congenital Amaurosis	
+Premature Ejaculation	
+Candidiasis	
+Hypercalcemia	
+Hyperparathyroidism, Secondary	
+Infertility, Male	
+Menorrhagia	
+Wilms Tumor	
+Polymyalgia Rheumatica	Skin
+Venous Insufficiency	
+Ventricular Fibrillation	
+Arthritis, Gouty	
+Eye Infections	
+Severe Combined Immunodeficiency	
+alpha 1-Antitrypsin Deficiency	
+Amyloid Neuropathies, Familial	CNS/Brain
+Tardive Dyskinesia	Skin
+Amino Acid Metabolism, Inborn Errors	
+Urinary Bladder, Neurogenic	Bladder/Urinary Tract
+Edema, Cardiac	
+Gaucher Disease	CNS/Brain
+Hepatorenal Syndrome	Liver
+Herpes Zoster	
+Keratitis	
+Hyperlipoproteinemia Type I	
+Myositis Ossificans	
+Myotonia	CNS/Brain
+Premenstrual Syndrome	
+Purpura, Thrombotic Thrombocytopenic	
+Regeneration	
+Skin Diseases, Infectious	Skin
+Spinal Fusion	
+Urinary Tract Infections	Bladder/Urinary Tract
+von Willebrand Diseases	
+Granulomatosis with Polyangiitis	Lung
+Thrombotic Microangiopathies	
+Reproductive Tract Infections	
+Hypoadrenocorticism, Familial	
+Bulimia	
+Cholestasis, Intrahepatic	Liver
+Dystonia	CNS/Brain
+Hyperoxaluria	
+Peptic Ulcer	Esophagus/Stomach
+Proctitis	
+Sialorrhea	
+Synovitis, Pigmented Villonodular	
+Tennis Elbow	
+Tachycardia, Ventricular	
+Hormone Replacement Therapy	
+Postoperative Nausea and Vomiting	
+Graves Ophthalmopathy	
+Bulimia Nervosa	
+Tendinopathy	
+Cryopyrin-Associated Periodic Syndromes	Skin
+Addison Disease	
+Afibrinogenemia	
+Fabry Disease	CNS/Brain
+Bursitis	
+Disseminated Intravascular Coagulation	
+Duodenal Ulcer	Esophagus/Stomach
+Dyspareunia	
+Esophageal and Gastric Varices	Esophagus/Stomach
+Esophagitis, Peptic	Esophagus/Stomach
+Postpartum Hemorrhage	
+Hypoparathyroidism	
+Hypophosphatasia	
+Labor, Induced	
+Lipoma	
+Metabolism, Inborn Errors	
+Mucocutaneous Lymph Node Syndrome	Skin
+Porphyrias	
+Stomatitis, Aphthous	
+Tachycardia, Supraventricular	
+Thrombophlebitis	
+Turner Syndrome	
+Still's Disease, Adult-Onset	Skin
+Hypophosphatemia	
+Tympanic Membrane Perforation	
+Antithrombin III Deficiency	
+Hyperammonemia	
+Optic Atrophy, Hereditary, Leber	CNS/Brain
+Erdheim-Chester Disease	
+Lymphatic Abnormalities	
+Lymphohistiocytosis, Hemophagocytic	
+Microscopic Polyangiitis	CNS/Brain
+Alstrom Syndrome	CNS/Brain
+Smith-Magenis Syndrome	CNS/Brain
+Atrophic Vaginitis	Vulva/Vagina
+Abortion, Spontaneous	
+Primary Immunodeficiency Diseases	
+Blepharoptosis	
+Cataplexy	CNS/Brain
+Cerebral Palsy	CNS/Brain
+Malignant Carcinoid Syndrome	
+Mucopolysaccharidosis IV	Skin
+Exocrine Pancreatic Insufficiency	Pancreas
+Phenylketonurias	CNS/Brain
+Polyuria	
+Puberty, Delayed	
+Puberty, Precocious	
+Zollinger-Ellison Syndrome	
+Helicobacter Infections	
+HIV Wasting Syndrome	
+Tyrosinemias	CNS/Brain
+Bardet-Biedl Syndrome	CNS/Brain
+Protoporphyria, Erythropoietic	
+Urea Cycle Disorders, Inborn	CNS/Brain
+Anemia, Hemolytic, Congenital Nonspherocytic	
+Anesthesia Recovery Period	
+Cryptorchidism	
+Drug Synergism	
+Factor XI Deficiency	
+Heart Defects, Congenital	
+Hepatitis A	Liver
+von Hippel-Lindau Disease	CNS/Brain
+Hyperbilirubinemia	
+Hypoprothrombinemias	
+Hypothyroidism	
+Jaundice	
+Leukopenia	
+Malignant Hyperthermia	
+alpha-Mannosidosis	
+Neoplasms, Connective Tissue	
+Osteomalacia	
+Paraphilic Disorders	
+Familial Mediterranean Fever	
+Rectal Fistula	Bowel
+Thrombasthenia	
+Trichomonas Infections	
+Vitamin D Deficiency	
+Wolman Disease	
+Mucopolysaccharidosis II	CNS/Brain
+Mucopolysaccharidosis VII	Skin
+Lymphangioleiomyomatosis	Uterus
+Hemangioblastoma	
+Heat Stroke	CNS/Brain
+Coagulation Protein Disorders	
+Hyperparathyroidism, Primary	
+Mevalonate Kinase Deficiency	CNS/Brain
+Perivascular Epithelioid Cell Neoplasms	
+Macular Degeneration	
+Cognition Disorders	
+Gastrointestinal Neoplasms	Bowel
+Acute Lung Injury	Lung
+Gastrointestinal Diseases	Bowel
+Acute Kidney Injury	Kidney
+Reperfusion Injury	
+Autistic Disorder	
+Liver Diseases	Liver
+Stress Disorders, Post-Traumatic	
+Lupus Nephritis	Kidney
+Carcinoid Tumor	
+Leiomyosarcoma	
+Urethritis	
+Renal Insufficiency	Kidney
+Lupus Erythematosus, Cutaneous	Skin
+Metabolic Syndrome	
+Glomerulosclerosis, Focal Segmental	Kidney
+Polycystic Kidney Diseases	Kidney
+Mucositis	
+Liposarcoma	
+Cholangitis, Sclerosing	Liver
+Hearing Loss	CNS/Brain
+Fragile X Syndrome	CNS/Brain
+Rett Syndrome	CNS/Brain
+Sarcoma, Synovial	
+Pemphigoid, Bullous	Skin
+Sarcoidosis	
+Frontotemporal Dementia	CNS/Brain
+Hepatitis	Liver
+Aminophenols	
+Bone Diseases	
+Eye Neoplasms	
+Tourette Syndrome	CNS/Brain
+Supranuclear Palsy, Progressive	CNS/Brain
+Dermatomyositis	Skin
+Delayed Graft Function	
+Phobia, Social	
+Cerebral Hemorrhage	CNS/Brain
+Intervertebral Disc	
+Glomerulonephritis	Kidney
+Polymyositis	CNS/Brain
+Hypereosinophilic Syndrome	
+Graft Rejection	
+Intermittent Claudication	
+Spasm	CNS/Brain
+Muscular Dystrophies, Limb-Girdle	CNS/Brain
+Bronchiectasis	Lung
+Headache	
+Short Bowel Syndrome	Bowel
+Cardiomyopathy, Dilated	
+Myotonic Dystrophy	CNS/Brain
+Myositis, Inclusion Body	CNS/Brain
+Borderline Personality Disorder	
+Gastritis	Esophagus/Stomach
+Photosensitivity Disorders	Skin
+Glomerulonephritis, Membranous	Kidney
+Pyoderma Gangrenosum	Skin
+Multiple System Atrophy	CNS/Brain
+Muscular Dystrophy, Facioscapulohumeral	CNS/Brain
+Pressure Ulcer	Skin
+Food Hypersensitivity	
+Immunologic Deficiency Syndromes	
+Tay-Sachs Disease	CNS/Brain
+Trigeminal Neuralgia	Peripheral Nervous System
+Complex Regional Pain Syndromes	CNS/Brain
+Dyssomnias	CNS/Brain
+Neurodevelopmental Disorders	
+Epileptic Syndromes	CNS/Brain
+Coronary Artery Bypass	
+Enuresis	
+Gastroenteritis	
+Gastrointestinal Motility	Bowel
+Otitis Media	
+Pre-Eclampsia	
+Retinopathy of Prematurity	
+Sandhoff Disease	CNS/Brain
+Dementia, Vascular	CNS/Brain
+Optic Neuropathy, Ischemic	Peripheral Nervous System
+Netherton Syndrome	Skin
+Healthcare-Associated Pneumonia	Lung
+Anorexia Nervosa	
+Brain Diseases	CNS/Brain
+Ehlers-Danlos Syndrome	Skin
+Mucopolysaccharidosis III	Skin
+Pterygium	
+Urination Disorders	
+Varicose Ulcer	Skin
+Neurofibromatosis 2	
+Aortic Valve Stenosis	
+Delirium	CNS/Brain
+Castleman Disease	
+Retinal Detachment	
+Takayasu Arteritis	Skin
+Thromboangiitis Obliterans	
+Tinnitus	CNS/Brain
+Churg-Strauss Syndrome	
+Mitochondrial Myopathies	CNS/Brain
+Lung Diseases, Interstitial	Lung
+Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Peripheral Nervous System
+Myopathies, Structural, Congenital	CNS/Brain
+Gallstones	
+Congenital Hyperinsulinism	
+Usher Syndromes	CNS/Brain
+Immunoglobulin G4-Related Disease	
+Basal Cell Nevus Syndrome	Skin
+Diverticulitis	Bowel
+Glycogen Storage Disease Type I	
+Joint Diseases	
+Leigh Disease	CNS/Brain
+Malabsorption Syndromes	
+Meniere Disease	
+Skin Aging	Skin
+Fibromatosis, Aggressive	
+Ornithine Carbamoyltransferase Deficiency Disease	CNS/Brain
+Idiopathic Hypersomnia	CNS/Brain
+Brain Diseases, Metabolic, Inborn	CNS/Brain
+Pachyonychia Congenita	Skin
+Macrophage Activation Syndrome	
+Diabetic Cardiomyopathies	
+Aspergillosis	
+Biliary Atresia	Liver
+Blepharitis	
+Fuchs' Endothelial Dystrophy	
+Gonorrhea	
+Hepatolenticular Degeneration	Liver
+Hyponatremia	
+Osteogenesis Imperfecta	Skin
+Pancreatic Diseases	Pancreas
+Presbyopia	
+Scleritis	
+Vestibular Diseases	
+Behavior, Addictive	
+Citrullinemia	CNS/Brain
+Hyperargininemia	CNS/Brain
+Demyelinating Autoimmune Diseases, CNS	CNS/Brain
+Muscular Dystrophy, Oculopharyngeal	CNS/Brain
+Argininosuccinic Aciduria	CNS/Brain
+Retinal Telangiectasis	
+Mastodynia	
+Morton Neuroma	CNS/Brain
+Amenorrhea	
+Carbohydrate Metabolism, Inborn Errors	
+Factor VII Deficiency	
+Galactosemias	CNS/Brain
+Hemolysis	
+Hyperplasia	
+Kernicterus	CNS/Brain
+Penile Induration	Skin
+Pericarditis	
+Pulmonary Alveolar Proteinosis	Lung
+HTLV-I Infections	
+Alagille Syndrome	
+Conduct Disorder	
+Unverricht-Lundborg Syndrome	CNS/Brain
+Alexander Disease	CNS/Brain
+Subcutaneous Fat	Skin
+Fibrosis	
+Metabolic Diseases	
+Respiration Disorders	Lung
+Skin Neoplasms	Skin
+Female Urogenital Diseases and Pregnancy Complications	
+Male Urogenital Diseases	
+Dyskinesias	Skin
+Nephrosclerosis	Kidney
+Testicular Neoplasms	
+Central Nervous System Neoplasms	CNS/Brain
+Cardiomyopathies	
+Pancreatitis	Pancreas
+Peripheral Nervous System Diseases	Peripheral Nervous System
+Urogenital Neoplasms	
+Sarcopenia	CNS/Brain
+Encephalitis	CNS/Brain
+Arrhythmias, Cardiac	
+Endocrine System Diseases	
+Kidney Diseases	Kidney
+Thymoma	
+Vaginal Neoplasms	Vulva/Vagina
+Hemorrhagic Fever, Ebola	
+Rhinitis	Lung
+Celiac Disease	
+Diarrhea	
+Neuroectodermal Tumors, Primitive	
+Fractures, Bone	
+Charcot-Marie-Tooth Disease	CNS/Brain
+Dermatitis, Contact	Skin
+Staphylococcal Infections	
+Gliosarcoma	
+Hepatitis, Alcoholic	Liver
+Bone Marrow Diseases	
+Telangiectasia, Hereditary Hemorrhagic	
+Herpes Simplex	Skin
+Myositis	CNS/Brain
+Nephritis	Kidney
+Subarachnoid Hemorrhage	CNS/Brain
+Thymus Neoplasms	
+Respiratory Syncytial Virus Infections	Lung
+Regenerative Medicine	
+Cardiomyopathy, Hypertrophic	
+Carcinoma, Adenoid Cystic	
+Endomyocardial Fibrosis	
+Mouth Neoplasms	
+Periodontitis	
+Trauma, Nervous System	CNS/Brain
+Down Syndrome	CNS/Brain
+Dwarfism	
+Hyperthyroidism	
+Rabies	
+Angelman Syndrome	CNS/Brain
+Neurofibromatoses	
+Amphetamine-Related Disorders	
+Mitochondrial Diseases	
+Hemochromatosis	
+Hypertension, Portal	
+Keloid	Skin
+Muscular Atrophy	CNS/Brain
+Nephrotic Syndrome	Kidney
+Glucose Intolerance	
+Aneurysm	
+Bronchopulmonary Dysplasia	Lung
+Raynaud Disease	
+Respiratory Distress Syndrome, Newborn	Lung
+Respiratory Insufficiency	Lung
+Vascular Diseases	
+Keratitis, Herpetic	
+Stem Cell Transplantation	
+Leukemia, Prolymphocytic, B-Cell	
+Bone Diseases, Metabolic	
+Uterine Cervical Dysplasia	Uterus
+Corneal Ulcer	
+Edema	
+Histiocytosis, Langerhans-Cell	Lung
+Mucopolysaccharidosis I	Skin
+Lymphedema	
+Meningioma	CNS/Brain
+Optic Neuritis	CNS/Brain
+Pulmonary Edema	Lung
+Xerostomia	
+Weight Gain	
+Fatigue Syndrome, Chronic	CNS/Brain
+Antiphospholipid Syndrome	
+Essential Tremor	CNS/Brain
+Bone Regeneration	
+Carcinoma, Squamous Cell	Skin
+Chromosome Deletion	
+Erythromelalgia	
+Esophagitis	Esophagus/Stomach
+Fecal Incontinence	
+Fibrosarcoma	
+Nevus	
+Proteinuria	
+Red-Cell Aplasia, Pure	
+Pouchitis	
+Capillary Leak Syndrome	
+Urinary Bladder, Underactive	Bladder/Urinary Tract
+Postoperative Cognitive Complications	
+Chondrosarcoma	
+Color Vision Defects	CNS/Brain
+Fanconi Anemia	
+Granulomatous Disease, Chronic	
+Leukodystrophy, Globoid Cell	CNS/Brain
+Lymphopenia	
+Spinal Stenosis	
+Tendon Injuries	
+Wiskott-Aldrich Syndrome	
+Glomerulonephritis, Membranoproliferative	Kidney
+Leukemia, Prolymphocytic, T-Cell	
+Urinary Retention	Bladder/Urinary Tract
+Pleural Effusion, Malignant	
+Gangliosidosis, GM1	CNS/Brain
+MELAS Syndrome	CNS/Brain
+Lichen Planus, Oral	Bowel
+Propionic Acidemia	
+Vascular Calcification	
+Barrett Esophagus	Esophagus/Stomach
+Blindness	CNS/Brain
+Coccidioidomycosis	
+Dysautonomia, Familial	CNS/Brain
+Fatigue	
+Hyperaldosteronism	
+Intervertebral Disc Displacement	
+Leukemia, Mast-Cell	
+Mucopolysaccharidosis VI	Skin
+Mycobacterium Infections, Nontuberculous	
+Neonatal Abstinence Syndrome	
+Pituitary Neoplasms	
+Rickets	
+Teratoma	
+Trisomy	
+Trophoblastic Neoplasms	
+Vertigo	CNS/Brain
+Corneal Edema	
+Choroid Diseases	
+Systemic Inflammatory Response Syndrome	
+Schnitzler Syndrome	
+Invasive Fungal Infections	
+Congenital Bone Marrow Failure Syndromes	
+Alveolitis, Extrinsic Allergic	Lung
+Amblyopia	CNS/Brain
+Arteriovenous Malformations	
+Blepharospasm	
+Marijuana Abuse	
+Cerebellar Diseases	CNS/Brain
+Cholangitis	Liver
+Corneal Diseases	
+Crigler-Najjar Syndrome	
+Cystinosis	
+Ectodermal Dysplasia	Skin
+Esophageal Achalasia	Esophagus/Stomach
+Fibrocystic Breast Disease	Breast
+Fissure in Ano	
+Homocystinuria	CNS/Brain
+Hyperprolactinemia	CNS/Brain
+Hypertrophy	
+Hypocalcemia	
+Disruptive, Impulse Control, and Conduct Disorders	
+Keratoconus	
+Darier Disease	Skin
+Lactation Disorders	Skin
+Leukodystrophy, Metachromatic	CNS/Brain
+Leukoplakia	
+Necrobiosis Lipoidica	Skin
+Penile Neoplasms	
+Pityriasis Rubra Pilaris	Skin
+Polyneuropathies	CNS/Brain
+Pseudohypoaldosteronism	
+Ross River virus	
+Skin Diseases, Vesiculobullous	Skin
+Trichotillomania	
+Wounds and Injuries	
+Choroideremia	
+Osteochondroma	
+Keratosis, Seborrheic	Skin
+Alcohol-Related Disorders	
+Retinoschisis	
+Steatorrhea	
+Hypoalphalipoproteinemias	
+Leukemia, Large Granular Lymphocytic	
+Virus Diseases	
+Substance-Related Disorders	
+Malaria	
+Musculoskeletal Diseases	
+Poisoning	
+Brain Injuries	CNS/Brain
+Dengue	
+Mycoses	
+Chordoma	
+Cytomegalovirus Infections	
+Organophosphate Poisoning	
+Niemann-Pick Diseases	CNS/Brain
+Fatty Liver, Alcoholic	Liver
+Amnesia	CNS/Brain
+Cerebral Infarction	CNS/Brain
+Dermatitis	Skin
+Enterocolitis, Necrotizing	Bowel
+Frailty	
+Deglutition Disorders	
+Picornaviridae Infections	
+Stomatitis	
+West Nile Fever	CNS/Brain
+Motor Neuron Disease	CNS/Brain
+Transfusion Reaction	
+Premenstrual Dysphoric Disorder	
+Chronic Traumatic Encephalopathy	CNS/Brain
+Anaphylaxis	
+Hirsutism	Skin
+Hypothalamic Diseases	CNS/Brain
+Lysosomal Storage Diseases	
+IgG Deficiency	
+Caliciviridae Infections	
+Anemia, Iron-Deficiency	
+Hepatic Insufficiency	Liver
+Hashimoto Disease	
+Leukemia, Myelomonocytic, Juvenile	
+Autoimmune Lymphoproliferative Syndrome	
+Bone Diseases, Infectious	
+Brain Edema	CNS/Brain
+Cryptococcosis	
+Herpesviridae Infections	
+Lecithin Cholesterol Acyltransferase Deficiency	
+Lyme Disease	
+Maple Syrup Urine Disease	CNS/Brain
+Osteopetrosis	
+Tularemia	
+POEMS Syndrome	CNS/Brain
+Pinguecula	
+Intraabdominal Infections	
+Pelvic Inflammatory Disease	
+Albinism	Skin
+Ataxia Telangiectasia	CNS/Brain
+Bone Cysts	
+Cholera	
+Gynecomastia	Skin
+Lipid Metabolism, Inborn Errors	
+Torticollis	
+Toxoplasmosis	
+Xeroderma Pigmentosum	
+Mycobacterium avium-intracellulare Infection	
+Lichen Sclerosus et Atrophicus	Skin
+Neurodegenerative Diseases	CNS/Brain
+Glycogen Storage Disease Type IIb	CNS/Brain
+Neurogenic Bowel	Bowel
+Osteogenesis	
+Muscular Dystrophies	CNS/Brain
+Zika Virus Infection	
+Coronavirus Infections	
+AIDS Dementia Complex	CNS/Brain
+Feeding and Eating Disorders	
+Retinal Artery Occlusion	
+Eye Injuries	CNS/Brain
+Guillain-Barre Syndrome	CNS/Brain
+Adenovirus Infections, Human	
+Leukoencephalopathy, Progressive Multifocal	CNS/Brain
+Neurilemmoma	
+Pneumococcal Infections	
+Pseudomonas Infections	
+Smallpox	
+Lafora Disease	CNS/Brain
+Abnormalities, Multiple	
+Ciliary Motility Disorders	Lung
+Conjunctivitis	
+Diabetes Insipidus	
+Ear Diseases	
+Hemiplegia	CNS/Brain
+Job Syndrome	
+Meningitis	CNS/Brain
+Noonan Syndrome	Skin
+Osteitis Deformans	
+Paget's Disease, Mammary	Breast
+Paget Disease, Extramammary	Breast
+Tetralogy of Fallot	
+Cerebral Amyloid Angiopathy	CNS/Brain
+Burkholderia Infections	
+Epstein-Barr Virus Infections	
+Intracranial Thrombosis	CNS/Brain
+Ataxia	CNS/Brain
+Corneal Dystrophies, Hereditary	
+Ductus Arteriosus, Patent	
+Hamartoma Syndrome, Multiple	
+Hyperventilation	Lung
+Hypothermia	
+Keratoconjunctivitis	
+Long QT Syndrome	
+Myocarditis	
+Nervous System Malformations	CNS/Brain
+Neurotic Disorders	
+Osteosclerosis	
+Phobic Disorders	
+Chronic Kidney Disease-Mineral and Bone Disorder	Kidney
+Schistosomiasis	
+Streptococcal Infections	
+Chagas Disease	
+Wolfram Syndrome	CNS/Brain
+Hepatitis E	Liver
+Gram-Positive Bacterial Infections	
+Amyloidosis, Familial	
+Abdominal Injuries	
+Immunosenescence	
+Cone-Rod Dystrophies	
+Ciliopathies	
+Birdshot Chorioretinopathy	
+Acidosis	
+Agammaglobulinemia	
+Alcoholic Intoxication	
+Anemia, Hemolytic, Congenital	
+Angioedema	Skin
+Bone Diseases, Developmental	
+Botulism	CNS/Brain
+Bradycardia	
+Chlamydia Infections	
+Cryptosporidiosis	
+Encephalitis, Japanese	CNS/Brain
+Encephalomyelitis, Acute Disseminated	CNS/Brain
+Encephalomyelitis, Venezuelan Equine	CNS/Brain
+Endocarditis	
+Fetal Diseases	
+Glycogen Storage Disease	
+Glycogen Storage Disease Type IV	
+Goiter	
+Haemophilus Infections	
+Hemorrhagic Fevers, Viral	
+Hepatic Encephalopathy	CNS/Brain
+Hyperinsulinism	
+Hyperparathyroidism	
+Impetigo	Skin
+Creutzfeldt-Jakob Syndrome	CNS/Brain
+Labyrinth Diseases	
+Marburg Virus Disease	
+Marfan Syndrome	Skin
+Meconium Aspiration Syndrome	Lung
+Melanosis	Skin
+Mucopolysaccharidoses	Skin
+Myelitis, Transverse	
+Ossification, Heterotopic	
+Paralysis	CNS/Brain
+Placental Insufficiency	
+Plague	
+Plant Poisoning	
+Pregnancy, Ectopic	
+Progeria	
+Retinitis	
+Rotavirus Infections	
+Sphingolipidoses	CNS/Brain
+Tachycardia	
+Urinary Calculi	Bladder/Urinary Tract
+Vaginitis	Vulva/Vagina
+Werner Syndrome	
+Yellow Fever	
+Zellweger Syndrome	
+Tumor Lysis Syndrome	
+Pyruvate Dehydrogenase Complex Deficiency Disease	CNS/Brain
+Spastic Paraplegia, Hereditary	CNS/Brain
+Aniridia	
+Postpoliomyelitis Syndrome	CNS/Brain
+Guided Tissue Regeneration, Periodontal	
+Myelinolysis, Central Pontine	CNS/Brain
+Hantavirus Infections	
+Congenital Disorders of Glycosylation	
+Iron Overload	
+Anti-Glomerular Basement Membrane Disease	Lung
+Hyperglycinemia, Nonketotic	CNS/Brain
+Carbamoyl-Phosphate Synthase I Deficiency Disease	CNS/Brain
+Myasthenic Syndromes, Congenital	CNS/Brain
+Vasospasm, Intracranial	CNS/Brain
+Hemangioma, Cavernous, Central Nervous System	CNS/Brain
+Hermanski-Pudlak Syndrome	Skin
+Polyomavirus Infections	
+Optic Atrophy, Autosomal Dominant	CNS/Brain
+Henipavirus Infections	
+CADASIL	CNS/Brain
+Fractures, Cartilage	
+Dysuria	
+Hyper-IgM Immunodeficiency Syndrome	
+Vulvodynia	
+Vitelliform Macular Dystrophy	
+Sarcoglycanopathies	Lung
+Fusariosis	Skin
+Hand-Foot Syndrome	Skin
+Chikungunya Fever	

data/indication_to_organ_mapping_confident.tsv

@@ -0,0 +1,422 @@
+indication_mesh_term	organ
+Breast Neoplasms	Breast
+Pancreatic Neoplasms	Pancreas
+Colorectal Neoplasms	Bowel
+Carcinoma, Non-Small-Cell Lung	Lung
+Ovarian Neoplasms	Ovary/Fallopian Tube
+Brain Neoplasms	CNS/Brain
+Glioblastoma	CNS/Brain
+Medulloblastoma	CNS/Brain
+Melanoma	Skin
+COVID-19	Lung
+Arthritis, Rheumatoid	Skin
+Alzheimer Disease	CNS/Brain
+Liver Neoplasms	Liver
+Psoriasis	Skin
+Kidney Neoplasms	Kidney
+Multiple Sclerosis	CNS/Brain
+Lung Neoplasms	Lung
+Asthma	Lung
+Parkinson Disease	CNS/Brain
+Inflammatory Bowel Diseases	Bowel
+Non-alcoholic Fatty Liver Disease	Liver
+Stomach Neoplasms	Esophagus/Stomach
+Urinary Bladder Neoplasms	Bladder/Urinary Tract
+Neuralgia	Peripheral Nervous System
+Pulmonary Disease, Chronic Obstructive	Lung
+Brain Ischemia	CNS/Brain
+Stroke	CNS/Brain
+Idiopathic Pulmonary Fibrosis	Lung
+Colitis, Ulcerative	Bowel
+Crohn Disease	Bowel
+Dermatitis, Atopic	Skin
+Esophageal Neoplasms	Esophagus/Stomach
+Small Cell Lung Carcinoma	Lung
+Lupus Erythematosus, Systemic	Skin
+Respiratory Distress Syndrome	Lung
+Amyotrophic Lateral Sclerosis	CNS/Brain
+Endometrial Neoplasms	Uterus
+Hypertension, Pulmonary	Lung
+Fallopian Tube Neoplasms	Ovary/Fallopian Tube
+Liver Cirrhosis	Liver
+Diabetic Nephropathies	Kidney
+Brain Injuries, Traumatic	CNS/Brain
+Uterine Cervical Neoplasms	Cervix
+Scleroderma, Systemic	Skin
+Scleroderma, Diffuse	Skin
+Scleroderma, Limited	Skin
+Diabetic Neuropathies	Peripheral Nervous System
+Epilepsy	CNS/Brain
+Kidney Failure, Chronic	Kidney
+Huntington Disease	CNS/Brain
+Migraine Disorders	CNS/Brain
+Irritable Bowel Syndrome	Bowel
+Eczema	Skin
+Spinal Cord Injuries	CNS/Brain
+Skin Diseases	Skin
+Pneumonia	Lung
+Hepatitis C	Liver
+Gastrointestinal Stromal Tumors	Bowel
+Acne Vulgaris	Skin
+Dementia	CNS/Brain
+Hepatitis B	Liver
+Multiple Sclerosis, Relapsing-Remitting	CNS/Brain
+Sjogren's Syndrome	Skin
+Rhinitis, Allergic	Lung
+Muscular Dystrophy, Duchenne	CNS/Brain
+Pruritus	Skin
+Arthritis, Psoriatic	Skin
+Lymphoma, T-Cell, Cutaneous	Skin
+Multiple Sclerosis, Chronic Progressive	CNS/Brain
+Urethral Neoplasms	Bladder/Urinary Tract
+Influenza, Human	Lung
+Diabetic Foot	Skin
+Urinary Bladder, Overactive	Bladder/Urinary Tract
+Fibromyalgia	CNS/Brain
+Liver Cirrhosis, Biliary	Liver
+Urinary Incontinence	Bladder/Urinary Tract
+Sleep Wake Disorders	CNS/Brain
+Neuralgia, Postherpetic	Peripheral Nervous System
+Endometriosis	Uterus
+Adrenal Gland Neoplasms	Kidney
+Epilepsies, Partial	CNS/Brain
+Alopecia	Skin
+Psychomotor Agitation	CNS/Brain
+Rhinitis, Allergic, Seasonal	Lung
+Sleep Initiation and Maintenance Disorders	CNS/Brain
+Hidradenitis Suppurativa	Skin
+Neoplasms, Basal Cell	Skin
+Dyskinesia, Drug-Induced	Skin
+Glomerulonephritis, IGA	Kidney
+Rosacea	Skin
+Lewy Body Disease	CNS/Brain
+Cough	Lung
+Alopecia Areata	Skin
+Apnea	Lung
+Keratosis, Actinic	Skin
+Arthritis, Juvenile	Skin
+Corneal Injuries	CNS/Brain
+Anus Neoplasms	Bowel
+Colitis	Bowel
+Lennox Gastaut Syndrome	CNS/Brain
+Prader-Willi Syndrome	CNS/Brain
+Gastroesophageal Reflux	Esophagus/Stomach
+Urticaria	Skin
+Behcet Syndrome	Skin
+Epidermolysis Bullosa	Skin
+Epilepsies, Myoclonic	CNS/Brain
+Muscular Atrophy, Spinal	CNS/Brain
+Neuromyelitis Optica	CNS/Brain
+Eosinophilic Esophagitis	Esophagus/Stomach
+Lipodystrophy	Skin
+Pemphigus	Skin
+Respiratory Tract Infections	Lung
+Vitiligo	Skin
+Ileus	Bowel
+Bronchiolitis Obliterans	Lung
+Muscle Spasticity	CNS/Brain
+Spinocerebellar Ataxias	CNS/Brain
+Pituitary ACTH Hypersecretion	CNS/Brain
+Emphysema	Lung
+Epilepsy, Absence	CNS/Brain
+Friedreich Ataxia	CNS/Brain
+Leishmaniasis	Skin
+Sinusitis	Lung
+Sleep Disorders, Circadian Rhythm	CNS/Brain
+Severe Acute Respiratory Syndrome	Lung
+Epilepsy, Generalized	CNS/Brain
+Leiomyoma	Uterus
+Pulmonary Embolism	Lung
+Status Epilepticus	CNS/Brain
+Common Cold	Lung
+Narcolepsy	CNS/Brain
+Nasal Polyps	Lung
+Neuronal Ceroid-Lipofuscinoses	CNS/Brain
+Polycystic Ovary Syndrome	Ovary/Fallopian Tube
+Prurigo	Skin
+Spasms, Infantile	CNS/Brain
+Angioedemas, Hereditary	Skin
+Hepatitis D	Liver
+Hepatitis, Viral, Human	Liver
+Restless Legs Syndrome	CNS/Brain
+Dermatitis, Seborrheic	Skin
+Adrenoleukodystrophy	CNS/Brain
+Dwarfism, Pituitary	CNS/Brain
+Nephritis, Hereditary	Kidney
+Acromegaly	CNS/Brain
+Cluster Headache	CNS/Brain
+Epilepsy, Tonic-Clonic	CNS/Brain
+Glycogen Storage Disease Type II	CNS/Brain
+Ichthyosis	Skin
+Rhinitis, Allergic, Perennial	Lung
+Stomach Ulcer	Esophagus/Stomach
+Bronchitis, Chronic	Lung
+Polymyalgia Rheumatica	Skin
+Amyloid Neuropathies, Familial	CNS/Brain
+Tardive Dyskinesia	Skin
+Urinary Bladder, Neurogenic	Bladder/Urinary Tract
+Gaucher Disease	CNS/Brain
+Hepatorenal Syndrome	Liver
+Myotonia	CNS/Brain
+Skin Diseases, Infectious	Skin
+Urinary Tract Infections	Bladder/Urinary Tract
+Granulomatosis with Polyangiitis	Lung
+Cholestasis, Intrahepatic	Liver
+Dystonia	CNS/Brain
+Peptic Ulcer	Esophagus/Stomach
+Cryopyrin-Associated Periodic Syndromes	Skin
+Fabry Disease	CNS/Brain
+Duodenal Ulcer	Esophagus/Stomach
+Esophageal and Gastric Varices	Esophagus/Stomach
+Esophagitis, Peptic	Esophagus/Stomach
+Mucocutaneous Lymph Node Syndrome	Skin
+Still's Disease, Adult-Onset	Skin
+Optic Atrophy, Hereditary, Leber	CNS/Brain
+Microscopic Polyangiitis	CNS/Brain
+Alstrom Syndrome	CNS/Brain
+Smith-Magenis Syndrome	CNS/Brain
+Atrophic Vaginitis	Vulva/Vagina
+Cataplexy	CNS/Brain
+Cerebral Palsy	CNS/Brain
+Mucopolysaccharidosis IV	Skin
+Exocrine Pancreatic Insufficiency	Pancreas
+Phenylketonurias	CNS/Brain
+Tyrosinemias	CNS/Brain
+Bardet-Biedl Syndrome	CNS/Brain
+Urea Cycle Disorders, Inborn	CNS/Brain
+Hepatitis A	Liver
+von Hippel-Lindau Disease	CNS/Brain
+Rectal Fistula	Bowel
+Mucopolysaccharidosis II	CNS/Brain
+Mucopolysaccharidosis VII	Skin
+Lymphangioleiomyomatosis	Uterus
+Heat Stroke	CNS/Brain
+Mevalonate Kinase Deficiency	CNS/Brain
+Gastrointestinal Neoplasms	Bowel
+Acute Lung Injury	Lung
+Gastrointestinal Diseases	Bowel
+Acute Kidney Injury	Kidney
+Liver Diseases	Liver
+Lupus Nephritis	Kidney
+Renal Insufficiency	Kidney
+Lupus Erythematosus, Cutaneous	Skin
+Glomerulosclerosis, Focal Segmental	Kidney
+Polycystic Kidney Diseases	Kidney
+Cholangitis, Sclerosing	Liver
+Hearing Loss	CNS/Brain
+Fragile X Syndrome	CNS/Brain
+Rett Syndrome	CNS/Brain
+Pemphigoid, Bullous	Skin
+Frontotemporal Dementia	CNS/Brain
+Hepatitis	Liver
+Tourette Syndrome	CNS/Brain
+Supranuclear Palsy, Progressive	CNS/Brain
+Dermatomyositis	Skin
+Cerebral Hemorrhage	CNS/Brain
+Glomerulonephritis	Kidney
+Polymyositis	CNS/Brain
+Spasm	CNS/Brain
+Muscular Dystrophies, Limb-Girdle	CNS/Brain
+Bronchiectasis	Lung
+Short Bowel Syndrome	Bowel
+Myotonic Dystrophy	CNS/Brain
+Myositis, Inclusion Body	CNS/Brain
+Gastritis	Esophagus/Stomach
+Photosensitivity Disorders	Skin
+Glomerulonephritis, Membranous	Kidney
+Pyoderma Gangrenosum	Skin
+Multiple System Atrophy	CNS/Brain
+Muscular Dystrophy, Facioscapulohumeral	CNS/Brain
+Pressure Ulcer	Skin
+Tay-Sachs Disease	CNS/Brain
+Trigeminal Neuralgia	Peripheral Nervous System
+Complex Regional Pain Syndromes	CNS/Brain
+Dyssomnias	CNS/Brain
+Epileptic Syndromes	CNS/Brain
+Gastrointestinal Motility	Bowel
+Sandhoff Disease	CNS/Brain
+Dementia, Vascular	CNS/Brain
+Optic Neuropathy, Ischemic	Peripheral Nervous System
+Netherton Syndrome	Skin
+Healthcare-Associated Pneumonia	Lung
+Brain Diseases	CNS/Brain
+Ehlers-Danlos Syndrome	Skin
+Mucopolysaccharidosis III	Skin
+Varicose Ulcer	Skin
+Delirium	CNS/Brain
+Takayasu Arteritis	Skin
+Tinnitus	CNS/Brain
+Mitochondrial Myopathies	CNS/Brain
+Lung Diseases, Interstitial	Lung
+Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	Peripheral Nervous System
+Myopathies, Structural, Congenital	CNS/Brain
+Usher Syndromes	CNS/Brain
+Basal Cell Nevus Syndrome	Skin
+Diverticulitis	Bowel
+Leigh Disease	CNS/Brain
+Skin Aging	Skin
+Ornithine Carbamoyltransferase Deficiency Disease	CNS/Brain
+Idiopathic Hypersomnia	CNS/Brain
+Brain Diseases, Metabolic, Inborn	CNS/Brain
+Pachyonychia Congenita	Skin
+Biliary Atresia	Liver
+Hepatolenticular Degeneration	Liver
+Osteogenesis Imperfecta	Skin
+Pancreatic Diseases	Pancreas
+Citrullinemia	CNS/Brain
+Hyperargininemia	CNS/Brain
+Demyelinating Autoimmune Diseases, CNS	CNS/Brain
+Muscular Dystrophy, Oculopharyngeal	CNS/Brain
+Argininosuccinic Aciduria	CNS/Brain
+Morton Neuroma	CNS/Brain
+Galactosemias	CNS/Brain
+Kernicterus	CNS/Brain
+Penile Induration	Skin
+Pulmonary Alveolar Proteinosis	Lung
+Unverricht-Lundborg Syndrome	CNS/Brain
+Alexander Disease	CNS/Brain
+Subcutaneous Fat	Skin
+Respiration Disorders	Lung
+Skin Neoplasms	Skin
+Dyskinesias	Skin
+Nephrosclerosis	Kidney
+Central Nervous System Neoplasms	CNS/Brain
+Pancreatitis	Pancreas
+Peripheral Nervous System Diseases	Peripheral Nervous System
+Sarcopenia	CNS/Brain
+Encephalitis	CNS/Brain
+Kidney Diseases	Kidney
+Vaginal Neoplasms	Vulva/Vagina
+Rhinitis	Lung
+Charcot-Marie-Tooth Disease	CNS/Brain
+Dermatitis, Contact	Skin
+Hepatitis, Alcoholic	Liver
+Herpes Simplex	Skin
+Myositis	CNS/Brain
+Nephritis	Kidney
+Subarachnoid Hemorrhage	CNS/Brain
+Respiratory Syncytial Virus Infections	Lung
+Trauma, Nervous System	CNS/Brain
+Down Syndrome	CNS/Brain
+Angelman Syndrome	CNS/Brain
+Keloid	Skin
+Muscular Atrophy	CNS/Brain
+Nephrotic Syndrome	Kidney
+Bronchopulmonary Dysplasia	Lung
+Respiratory Distress Syndrome, Newborn	Lung
+Respiratory Insufficiency	Lung
+Uterine Cervical Dysplasia	Uterus
+Histiocytosis, Langerhans-Cell	Lung
+Mucopolysaccharidosis I	Skin
+Meningioma	CNS/Brain
+Optic Neuritis	CNS/Brain
+Pulmonary Edema	Lung
+Fatigue Syndrome, Chronic	CNS/Brain
+Essential Tremor	CNS/Brain
+Carcinoma, Squamous Cell	Skin
+Esophagitis	Esophagus/Stomach
+Urinary Bladder, Underactive	Bladder/Urinary Tract
+Color Vision Defects	CNS/Brain
+Leukodystrophy, Globoid Cell	CNS/Brain
+Glomerulonephritis, Membranoproliferative	Kidney
+Urinary Retention	Bladder/Urinary Tract
+Gangliosidosis, GM1	CNS/Brain
+MELAS Syndrome	CNS/Brain
+Lichen Planus, Oral	Bowel
+Barrett Esophagus	Esophagus/Stomach
+Blindness	CNS/Brain
+Dysautonomia, Familial	CNS/Brain
+Mucopolysaccharidosis VI	Skin
+Vertigo	CNS/Brain
+Alveolitis, Extrinsic Allergic	Lung
+Amblyopia	CNS/Brain
+Cerebellar Diseases	CNS/Brain
+Cholangitis	Liver
+Ectodermal Dysplasia	Skin
+Esophageal Achalasia	Esophagus/Stomach
+Fibrocystic Breast Disease	Breast
+Homocystinuria	CNS/Brain
+Hyperprolactinemia	CNS/Brain
+Darier Disease	Skin
+Lactation Disorders	Skin
+Leukodystrophy, Metachromatic	CNS/Brain
+Necrobiosis Lipoidica	Skin
+Pityriasis Rubra Pilaris	Skin
+Polyneuropathies	CNS/Brain
+Skin Diseases, Vesiculobullous	Skin
+Keratosis, Seborrheic	Skin
+Brain Injuries	CNS/Brain
+Niemann-Pick Diseases	CNS/Brain
+Fatty Liver, Alcoholic	Liver
+Amnesia	CNS/Brain
+Cerebral Infarction	CNS/Brain
+Dermatitis	Skin
+Enterocolitis, Necrotizing	Bowel
+West Nile Fever	CNS/Brain
+Motor Neuron Disease	CNS/Brain
+Chronic Traumatic Encephalopathy	CNS/Brain
+Hirsutism	Skin
+Hypothalamic Diseases	CNS/Brain
+Hepatic Insufficiency	Liver
+Brain Edema	CNS/Brain
+Maple Syrup Urine Disease	CNS/Brain
+POEMS Syndrome	CNS/Brain
+Albinism	Skin
+Ataxia Telangiectasia	CNS/Brain
+Gynecomastia	Skin
+Lichen Sclerosus et Atrophicus	Skin
+Neurodegenerative Diseases	CNS/Brain
+Glycogen Storage Disease Type IIb	CNS/Brain
+Neurogenic Bowel	Bowel
+Muscular Dystrophies	CNS/Brain
+AIDS Dementia Complex	CNS/Brain
+Eye Injuries	CNS/Brain
+Guillain-Barre Syndrome	CNS/Brain
+Leukoencephalopathy, Progressive Multifocal	CNS/Brain
+Lafora Disease	CNS/Brain
+Ciliary Motility Disorders	Lung
+Hemiplegia	CNS/Brain
+Meningitis	CNS/Brain
+Noonan Syndrome	Skin
+Paget's Disease, Mammary	Breast
+Paget Disease, Extramammary	Breast
+Cerebral Amyloid Angiopathy	CNS/Brain
+Intracranial Thrombosis	CNS/Brain
+Ataxia	CNS/Brain
+Hyperventilation	Lung
+Nervous System Malformations	CNS/Brain
+Chronic Kidney Disease-Mineral and Bone Disorder	Kidney
+Wolfram Syndrome	CNS/Brain
+Hepatitis E	Liver
+Angioedema	Skin
+Botulism	CNS/Brain
+Encephalitis, Japanese	CNS/Brain
+Encephalomyelitis, Acute Disseminated	CNS/Brain
+Encephalomyelitis, Venezuelan Equine	CNS/Brain
+Hepatic Encephalopathy	CNS/Brain
+Impetigo	Skin
+Creutzfeldt-Jakob Syndrome	CNS/Brain
+Marfan Syndrome	Skin
+Meconium Aspiration Syndrome	Lung
+Melanosis	Skin
+Mucopolysaccharidoses	Skin
+Paralysis	CNS/Brain
+Sphingolipidoses	CNS/Brain
+Urinary Calculi	Bladder/Urinary Tract
+Vaginitis	Vulva/Vagina
+Pyruvate Dehydrogenase Complex Deficiency Disease	CNS/Brain
+Spastic Paraplegia, Hereditary	CNS/Brain
+Postpoliomyelitis Syndrome	CNS/Brain
+Myelinolysis, Central Pontine	CNS/Brain
+Anti-Glomerular Basement Membrane Disease	Lung
+Hyperglycinemia, Nonketotic	CNS/Brain
+Carbamoyl-Phosphate Synthase I Deficiency Disease	CNS/Brain
+Myasthenic Syndromes, Congenital	CNS/Brain
+Vasospasm, Intracranial	CNS/Brain
+Hemangioma, Cavernous, Central Nervous System	CNS/Brain
+Hermanski-Pudlak Syndrome	Skin
+Optic Atrophy, Autosomal Dominant	CNS/Brain
+CADASIL	CNS/Brain
+Sarcoglycanopathies	Lung
+Fusariosis	Skin
+Hand-Foot Syndrome	Skin

data/organ_to_conditions_mapping.json

@@ -0,0 +1,1067 @@
+{
+  "Bowel": [
+    "Colorectal Cancer",
+    "Metastatic Colorectal Cancer",
+    "Ulcerative Colitis",
+    "Colorectal Neoplasms",
+    "Rectal Cancer",
+    "Crohn's Disease",
+    "Gastrointestinal Stromal Tumors",
+    "Colorectal Cancer Metastatic",
+    "Advanced Colorectal Cancer",
+    "Colon Cancer",
+    "Irritable Bowel Syndrome",
+    "Short Bowel Syndrome",
+    "Colitis, Ulcerative",
+    "Crohn Disease",
+    "Colorectal Carcinoma",
+    "Colon Cancer; Rectal Cancer",
+    "Inflammatory Bowel Diseases",
+    "Rectal Neoplasms",
+    "Colorectal Cancer; Metastatic Cancer",
+    "Advanced Gastrointestinal Stromal Tumor",
+    "Colorectal Cancer; Liver Metastases",
+    "Gastrointestinal Stromal Tumor",
+    "Metastatic Colorectal Cancer (mCRC)",
+    "Metastatic Colorectal Adenocarcinoma",
+    "Gastrointestinal Neoplasms",
+    "Upper Gastrointestinal Bleeding",
+    "Irritable Bowel Syndrome With Diarrhea",
+    "Gastrointestinal Cancer",
+    "Colon Cancer; Colorectal Cancer",
+    "Colorectal Cancer (CRC)",
+    "Rectal Adenocarcinoma",
+    "Colon Adenocarcinoma",
+    "Colonoscopy",
+    "Multiple Cancers (Pancreatic, Lung, Esophagogastric, Colorectal, Breast)",
+    "Gastrointestinal Cancers",
+    "BRAF V600E-mutant Metastatic Colorectal Cancer",
+    "Metastatic Colorectal Cancer; MSI",
+    "Pediatric Crohn's Disease",
+    "High-risk Locally Advanced Colorectal Cancer",
+    "Lymphoma and Small Intestine Cancer",
+    "Advanced or Metastatic Solid Tumors; Advanced or Metastatic Colorectal Cancer (mCRC)",
+    "Stage IV Colorectal Cancer",
+    "Inflammatory Bowel Disease",
+    "Collagenous Colitis",
+    "Colorectal Cancer; Liver Metastasis",
+    "Colorectal Cancer with Liver Metastases",
+    "Colorectal Cancer Stage IV",
+    "Colorectal Cancer Metastatic; mCRC",
+    "Solid Tumors and Gastrointestinal Cancer",
+    "Solid Tumor; Colorectal Cancer",
+    "Colorectal; Cancer",
+    "Intestinal Neoplasms",
+    "Ulcerative Colitis Acute",
+    "Colorectal and Gastroesophageal Cancers",
+    "Colorectal Cancer; Metastatic Colorectal Cancer With RAS Mutation",
+    "Inflammatory Bowel Disease (IBD)",
+    "Gastrointestinal Stromal Tumor (GIST)",
+    "Gastrointestinal Neoplasm",
+    "Locally Advanced Rectal Cancer",
+    "Necrotizing Enterocolitis",
+    "HER2-expressing Gastrointestinal Cancers",
+    "Locally Recurrent Rectal Cancer",
+    "Biliary and Colorectal Neoplasms",
+    "Refractory Metastatic Colorectal Cancer",
+    "Recurrent Colon Carcinoma; Recurrent Rectal Carcinoma; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer",
+    "Microbial Colonization",
+    "Small Intestinal Adenocarcinoma",
+    "Colon Cancer Liver Metastasis",
+    "Stage IIA Colon Cancer",
+    "Metastatic Colorectal Cancer with Chemotherapy Effects",
+    "Metastatic Colon Cancer",
+    "Ulcerative Colitis; Crohn's Disease",
+    "Ulcerative Colitis; Inflammatory Bowel Diseases",
+    "Colorectal Cancer; Cholangiocarcinoma",
+    "Metastatic Colorectal Cancer with Chemotherapy Complications",
+    "Colonic Neoplasms",
+    "Mucinous Adenocarcinoma of the Colon and Rectum",
+    "Upper Gastrointestinal Hemorrhage",
+    "Microsatellite Stable Metastatic Colorectal Cancer",
+    "Microscopic Colitis",
+    "Colorectal Adenocarcinoma",
+    "Colorectal Adenoma",
+    "Colorectal Cancer; Cancer of Pancreas; Pancreatic Neoplasm; Malignant Neoplasm of Large Intestine; Malignant Tumor of Colon; Colon Carcinoma; Cancer of Colon; Pancreatic Cancer",
+    "Non-small Cell Lung Carcinoma; Urothelial Carcinoma; Gastrointestinal Carcinoma, Non-colon; Upper Aerodigestive Tract Carcinoma",
+    "Lymphoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific",
+    "Anorectal Disorders",
+    "Metastatic Colorectal Carcinoma; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Unresectable Carcinoma",
+    "Metastatic Colorectal Cancer; Metastatic Cancer to Liver",
+    "Metastatic Colorectal Cancer; Recurrent Colorectal Cancer",
+    "Colorectal Cancer with Liver Metastasis",
+    "Colorectal Cancer; Peritoneal Metastasis",
+    "Metastatic Microsatellite Stable Colorectal Carcinoma; Refractory Microsatellite Stable Colorectal Carcinoma; Stage IV Colorectal Cancer AJCC v8",
+    "Colorectal Neoplasms Malignant",
+    "Colorectal Neoplasm",
+    "Colorectal Carcinoma; Colorectal Neoplasms; Colorectal Tumor; Colorectal Adenocarcinoma; Colorectal Cancer (CRC); Colorectal Cancer; Colon Cancer; Colon Adenocarcinoma; Colon Carcinoma; Colon Neoplasm",
+    "Colorectal Cancer; Colorectal Liver Metastases",
+    "BRAF V600E-mutated /MSS Metastatic Colorectal Cancer; Vemurafenib (BRAFi) Plus Cetuximab (EGFRi) Combined With PD-1 Monoclonal Antibody",
+    "MSS; RAS-mutant Colorectal Cancer",
+    "Venous Thromboembolism; Gastro Intestinal Bleeding; Blood Clot",
+    "Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis",
+    "Neoplasms, Colorectal",
+    "Colorectal Cancer Metastatic; Liver Metastasis Colon Cancer",
+    "Metastatic Colorectal Neoplasms",
+    "Metastatic Cancer; Colorectal Cancer; Colorectal Adenocarcinoma",
+    "Adenocarcinoma of Colon; Adenocarcinoma of Rectum; Metastatic Disease",
+    "Advanced Colorectal Carcinoma",
+    "Advanced Colorectal Cancer; Metastatic Colorectal Cancer",
+    "Small Intestinal Bacterial Overgrowth",
+    "Advanced Colorectal Cancer in the Third-line Treatment and Beyond; pMMR/MSS Advanced Colorectal Cancer",
+    "Metastatic Colon Cancer to Liver",
+    "Resected Liver Metastases From Colorectal Cancer",
+    "Advanced Malignant Neoplasm; Colorectal Carcinoma Metastatic in the Liver; Metastatic Malignant Neoplasm in the Liver; Refractory Malignant Neoplasm",
+    "Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer",
+    "Rheumatoid Arthritis and Inflammatory Bowel Disease",
+    "Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer",
+    "Advanced Solid Tumor; Non-Small Cell Lung Cancer; Colorectal Cancer",
+    "Advanced Gastrointestinal Cancer",
+    "Stage II-III Colon Cancer",
+    "Gastro Intestinal Stromal Tumor",
+    "Crohn Disease; Ulcerative Colitis",
+    "Critical Illness with Gastrointestinal Complications",
+    "Gastrointestinal Adenocarcinoma",
+    "Crohn's Disease; Ulcerative Colitis",
+    "Recurrent or Metastatic Colorectal Cancer",
+    "Recurrent Rectal Cancer",
+    "Irritable Bowel Syndrome with SIBO",
+    "Locally Advanced Unresectable or Stage IV Colorectal Cancer"
+  ],
+    "Lung": [
+      "Asthma",
+      "Lung Cancer",
+      "Carcinoma, Non-Small-Cell Lung",
+      "Non-small Cell Lung Cancer",
+      "Advanced Non-Small Cell Lung Cancer",
+      "Non Small Cell Lung Cancer",
+      "Pulmonary Disease, Chronic Obstructive",
+      "Pulmonary Arterial Hypertension",
+      "Chronic Obstructive Pulmonary Disease",
+      "Small Cell Lung Cancer",
+      "Pneumonia, Pneumocystis Carinii; HIV Infections",
+      "COPD",
+      "Pulmonary Hypertension",
+      "Non-Small-Cell Lung Carcinoma",
+      "Chronic Obstructive Pulmonary Disease (COPD)",
+      "Idiopathic Pulmonary Fibrosis",
+      "Non-Squamous Non-Small Cell Lung Cancer",
+      "Non-Small-Cell Lung Cancer",
+      "Non-small-cell Lung Cancer",
+      "Pulmonary Embolism",
+      "Mesothelioma",
+      "Lung Neoplasms",
+      "Non-small Cell Lung Cancer (NSCLC)",
+      "Acute Respiratory Distress Syndrome",
+      "Lung Cancer, Non-Small Cell",
+      "Malignant Pleural Mesothelioma",
+      "Non-small Cell Lung Cancer Metastatic",
+      "Pneumonia",
+      "Lung Adenocarcinoma",
+      "Bronchial Asthma",
+      "Malignant Mesothelioma",
+      "Malignant Pleural Effusion",
+      "Small Cell Lung Carcinoma",
+      "Non Small Cell Lung Carcinoma",
+      "Metastatic Non Small Cell Lung Cancer",
+      "Carcinoma, Non-Small Cell Lung",
+      "Stage IV Non-small Cell Lung Cancer",
+      "Pleural Mesothelioma",
+      "Respiratory Syncytial Virus Infections",
+      "Relapsed Small Cell Lung Cancer",
+      "Small Cell Lung Cancer Extensive Stage",
+      "Bronchiectasis",
+      "Pediatric Asthma",
+      "Non-squamous, Non-Small Cell Lung Cancer",
+      "Non Small Cell Lung Cancer (NSCLC)",
+      "COVID-19 Pneumonia",
+      "Non-Small Cell Lung Cancer with Gene Mutations",
+      "Non-Small Cell Lung Cancer (NSCLC)",
+      "Advanced Solid Tumor; Pancreatic Adenocarcinoma; Malignant Melanoma (Cutaneous); Non-small Cell Lung Cancer (NSCLC)",
+      "COPD with Pulmonary Hypertension",
+      "Carcinoma, Non-Small-Cell Lung; Immune-Related Adverse Events",
+      "Bronchopulmonary Dysplasia",
+      "Lung Cancer Stage III with Mutation",
+      "Multiple Cancers (Pancreatic, Lung, Esophagogastric, Colorectal, Breast)",
+      "Non-small-cell Lung Carcinoma",
+      "Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer",
+      "Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific",
+      "Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8",
+      "Metastatic Non-Small Cell Lung Cancer",
+      "Recurrent Non-small Cell Lung Cancer",
+      "Lung Cancer, Nonsmall Cell",
+      "Lung Cancer with Hypermethylation",
+      "Lung Cancer; Non-Small Cell Lung Cancer",
+      "Lung Non-Small Cell Carcinoma; Lung Non-Small Cell Squamous Carcinoma; Lung Non-Squamous Non-Small Cell Carcinoma; Stage II Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8",
+      "Locally Advanced or Metastatic Non-Small Cell Lung Cancer",
+      "First Line Non-Small Cell Lung Cancer",
+      "Extensive Stage Small Cell Lung Cancer",
+      "Persistent Pulmonary Hypertension of the Newborn",
+      "Pulmonary Tuberculosis",
+      "Non-small Cell Lung Carcinoma",
+      "Non-squamous Non-small Cell Lung Cancer",
+      "Carcinoma, Non-small Cell Lung",
+      "Copd",
+      "Community-acquired Pneumonia",
+      "Small-cell Lung Cancer; Small Cell Lung Carcinoma",
+      "Community-acquired Respiratory Infections",
+      "Non-Small Cell Lung Cancer; Carcinoma, Squamous Cell; Adenocarcinoma",
+      "Stage IV Lung Cancer",
+      "Extensive-stage Small-cell Lung Cancer",
+      "Cough Variant Asthma",
+      "COPD (Chronic Obstructive Pulmonary Disease)",
+      "Hepatopulmonary Syndrome",
+      "Metastatic Lung Cancer",
+      "Lung Carcinoma",
+      "Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma",
+      "Carcinoma, Non-Small-Cell Lung; Synchronous Neoplasms",
+      "Non Small-cell Lung Cancer",
+      "Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC V8; Clinical Stage IV Cutaneous Melanoma AJCC V8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC V8; Pathologic Stage IIIA Cutaneous Melanoma AJCC V8; Pathologic Stage IIIB Cutaneous Melanoma AJCC V8; Pathologic Stage IIIC Cutaneous Melanoma AJCC V8; Pathologic Stage IIID Cutaneous Melanoma AJCC V8; Pathologic Stage IV Cutaneous Melanoma AJCC V8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC V8; Stage III Renal Cell Cancer AJCC V8; Stage IIIA Lung Cancer AJCC V8; Stage IIIB Lung Cancer AJCC V8; Stage IIIC Lung Cancer AJCC V8; Stage IV Lung Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8; Stage IVA Lung Cancer AJCC V8; Stage IVB Lung Cancer AJCC V8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma",
+      "Metastatic Non-small Cell Lung Cancer",
+      "EGFR Positive Non-small Cell Lung Cancer",
+      "EGFR-mutant Non-small Cell Lung Cancer",
+      "Respiratory Syncytial Virus Infection",
+      "Respiratory Tract Infections",
+      "Advanced Malignant Mesothelioma; Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma",
+      "Metastatic Non-Small Cell Lung Cancer (NSCLC)",
+      "Pulmonary Aspiration of Gastric Contents",
+      "Advanced Non-small Cell Lung Cancer",
+      "Chronic Thromboembolic Pulmonary Hypertension; Idiopathic Pulmonary Arterial Hypertension",
+      "Bronchiolitis Obliterans",
+      "Bronchiolitis",
+      "Heart Failure with Pulmonary Hypertension",
+      "Lung Neoplasm Malignant",
+      "Non-small Cell Lung Cancer Stage IV",
+      "Pulmonary Sarcoidosis",
+      "Acute Hypoxemic Respiratory Failure",
+      "Carcinoma, Small Cell; Lung Cancer; Small Cell Lung Cancer",
+      "Respiratory Diseases",
+      "Covid19; SARS (Severe Acute Respiratory Syndrome)",
+      "Carcinoma; Non-Small-Cell Lung",
+      "Non-Small Cell Lung Cancer",
+      "Acute Exacerbation of Chronic Obstructive Pulmonary Disease",
+      "Non Small Cell Lung Cancer; Hepatitis B",
+      "Non Small Cell Lung Cancer; Small-cell Lung Cancer",
+      "Non Small Cell Lung Cancer; Lung Cancer",
+      "Nonsquamous Nonsmall Cell Neoplasm of Lung",
+      "Lungcancer",
+      "Lung Transplant",
+      "ASTHMA",
+      "Non-small Cell Lung Cancer (NSCLC); EGFR-TKI Resistant Mutation; EGFR-TKI Sensitizing Mutation; Germline Mutations; Somatic Mutation",
+      "Non-squamous Nonsmall Cell Neoplasm of Lung",
+      "Non-small-cell Lung Cancer With Somatic EGFR Mutations",
+      "Non-small Cell Lung Carcinoma; Urothelial Carcinoma; Gastrointestinal Carcinoma, Non-colon; Upper Aerodigestive Tract Carcinoma",
+      "Head and Neck Cancer; Lung Cancer",
+      "Non-small Cell Lung Cancer(NSCLC)",
+      "Asthma with Obesity",
+      "Chronic Thromboembolic Pulmonary Hypertension",
+      "Non-Small Cell Lung Cancer with Genetic Mutations",
+      "Breast and Lung Cancer",
+      "HER2-mutant Non-Small Cell Lung Cancer",
+      "Lung Neoplasm",
+      "Metastatic Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8",
+      "Non-Small Cell Lung Carcinoma with EGFR Mutation",
+      "Ventilator Associated Pneumonia",
+      "Arterial Pulmonary Hypertension (PAH)",
+      "Metastatic Castration-Resistant Prostate Cancer; Metastatic Breast Cancer; Non-small Cell Lung Cancer; Advanced Solid Tumors",
+      "Breast Cancer; Non-small Cell Lung Cancer; Melanoma; Brain Metastases",
+      "Acute Respiratory Tract Infections",
+      "Severe Asthma",
+      "Severe Acute Respiratory Syndrome",
+      "Recurrent Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIB Non-Small Cell Lung Cancer; Stage IV Non-Small Cell Lung Cancer",
+      "Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)",
+      "Lung Adenocarcinoma and Squamous Cell Carcinoma",
+      "Pleural Effusion",
+      "Small-Cell Lung Cancer",
+      "Advanced Lung Adenocarcinoma",
+      "Small-cell Lung Cancer",
+      "Pleural Neoplasm",
+      "Bacterial Pneumonia",
+      "Acute Pulmonary Embolism",
+      "Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer AJCC v7",
+      "Skin Rash with Lung Cancer",
+      "Allergic Bronchopulmonary Aspergillosis",
+      "Advanced Non Small Cell Lung Cancer; MET Exon 14 Mutation",
+      "Advanced Non Small Cell Lung Cancer (NSCLC)",
+      "Pulmonary Arterial Hypertension (PAH)",
+      "Pulmonary Arterial Hypertension; Pulmonary Hypertension",
+      "Leptomeningeal Metastasis; Non-small Cell Lung Cancer; EGFR Activating Mutation",
+      "Advanced Non-squamous Cell Non-small Cell Lung Cancer",
+      "Bronchoscopy with Sedation",
+      "Respiratory Failure",
+      "Advanced Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8",
+      "EGFR Mutation Positive Non Small Cell Lung Cancer",
+      "EGFR Gene Mutation; Nonsmall Cell Lung Cancer",
+      "SMALL CELL LUNG CARCINOMA",
+      "Advanced Solid Tumor; Non-Small Cell Lung Cancer; Colorectal Cancer",
+      "Stage IV Non-Small Cell Lung Cancer",
+      "Lung Cancer (NSCLC)",
+      "Stage III Non-Small Cell Lung Cancer",
+      "Lower Respiratory Tract Infection",
+      "Lung Cancer; Non-small Cell Lung Cancer",
+      "Lung Diseases",
+      "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN",
+      "Lung Cancer; Lung Diseases",
+      "Lung Cancer, Non-Small Cell; Non-Small-Cell Lung Cancer",
+      "Stage IB Lung Non-Small Cell Carcinoma AJCC v7; Stage II Lung Non-Small Cell Cancer AJCC v7; Stage IIA Lung Cancer AJCC v8; Stage IIB Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIA Lung Non-Small Cell Cancer AJCC v7; Stage IIIB Lung Cancer AJCC v8",
+      "Squamous Cell Lung Carcinoma",
+      "Recurrent Small Cell Lung Carcinoma",
+      "Persistent Pulmonary Hypertension of Newborn",
+      "Extensive Stage Small Cell Lung Cancer (ES-SCLC)",
+      "Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer",
+      "Peritoneal Malignant Mesothelioma",
+      "Extensive-stage Small Cell Lung Cancer",
+      "Deep Venous Thrombosis; Pulmonary Embolism",
+      "EGFR-Positive Non-Small Cell Lung Cancer",
+      "Advanced Cancer; Metastatic Cancer; Non-Hodgkin's Lymphoma; Metastatic Breast Cancer; Malignant Mesothelioma; Non-small Cell Lung Cancer",
+      "Solid Tumors and Non-small Cell Lung Carcinoma"
+    ],
+  "Esophagus/Stomach": [
+    "Gastric Cancer",
+    "Esophageal Cancer",
+    "Esophageal Squamous Cell Carcinoma",
+    "Eosinophilic Esophagitis",
+    "Gastroesophageal Reflux Disease",
+    "Esophageal and Gastric Cancer",
+    "Stomach Neoplasms",
+    "Advanced Gastric Cancer",
+    "Gastric Ulcer",
+    "Gastroesophageal Reflux",
+    "GERD",
+    "Stomach Neoplasm",
+    "Gastric Adenocarcinoma",
+    "Esophageal Neoplasms",
+    "Gastroesophageal Reflux Disease (GERD)",
+    "Stomach Cancer",
+    "Multiple Cancers (Pancreatic, Lung, Esophagogastric, Colorectal, Breast)",
+    "Esophageal Carcinoma",
+    "Metastatic Gastro-esophageal Adenocarcinoma",
+    "Advanced Gastroesophageal Adenocarcinoma",
+    "Reflux Esophagitis",
+    "Advanced Esophageal Carcinoma",
+    "Metastatic Gastric Cancer",
+    "Colorectal and Gastroesophageal Cancers",
+    "Esophageal Squamous Cell Carcinoma; Oligometastatic Disease; Radiotherapy",
+    "Esophagogastric Adenocarcinoma",
+    "Erosive Esophagitis",
+    "Stage IV Gastric Cancer With Metastasis",
+    "Gastric Acid Studies",
+    "Gastric and Gastroesophageal Junction Adenocarcinoma",
+    "Gastro-oesophageal Reflux Disease",
+    "Stomach Ulcer",
+    "Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma",
+    "Pulmonary Aspiration of Gastric Contents",
+    "Advanced Gastric Adenocarcinoma",
+    "Advanced Gastric and Gastro-esophageal Junction Cancer",
+    "Helicobacter-associated Gastritis",
+    "Esophageal and Gastroesophageal Junction Cancer",
+    "Gastric and Gastroesophageal Junction Cancer",
+    "Metastatic Gastric Cancer; Locally Advanced Gastric Adenocarcinoma; Gastric Cancer Adenocarcinoma Metastatic",
+    "HER2-positive Gastroesophageal Cancer",
+    "Gastroesophageal Cancer with HER2 Mutation",
+    "Eosinophilic Esophagitis (EoE)",
+    "Advanced Esophageal Squamous Cell Carcinoma",
+    "HER-2 Positive Gastric or Gastroesophageal Junction Adenocarcinoma",
+    "Esophageal Cancer; Cancer of the Esophagus; Esophagus Cancer; Esophageal Neoplasm; Cancer of Esophagus",
+    "Esophageal Cancer; Gastric Cancer; Stomach Cancer",
+    "Esophagus Squamous Cell Carcinoma",
+    "Esophagitis",
+    "Esophageal Neoplasm",
+    "Gastro Esophageal Reflux",
+    "Gastroesophageal Junction Adenocarcinoma",
+    "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN",
+    "Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma",
+    "Gastric Cancer; GastroEsophageal Cancer",
+    "Gastric Cancer; Adenocarcinoma of the Esophagogastric Junction",
+    "Chemotherapy-Induced Gastric Toxicity",
+    "Gastric and Pancreatic Cancer",
+    "Gastric Cancer with Peritoneal Metastases",
+    "Gastric Cancer; HER2 Overexpressing Gastric Carcinoma",
+    "Gastric and Gastro-esophageal Junction Cancer",
+    "Locally Advanced Gastric Adenocarcinoma"
+  ],
+  "Pancreas": [
+    "Pancreatic Cancer",
+    "Metastatic Pancreatic Cancer",
+    "Pancreatic Adenocarcinoma",
+    "Pancreatic Ductal Adenocarcinoma",
+    "Pancreatic Neoplasms",
+    "Metastatic Pancreatic Adenocarcinoma",
+    "Advanced Breast Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Prostate Carcinoma; Advanced Sarcoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Recurrent Adult Soft Tissue Sarcoma; Recurrent Breast Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Prostate Carcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8",
+    "Advanced Pancreatic Cancer",
+    "Pancreas Cancer",
+    "Pancreatic Ductal Carcinoma",
+    "Metastatic Pancreatic Adenocarcinoma; Recurrent Pancreatic Carcinoma; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer",
+    "Metastatic Pancreatic Ductal Adenocarcinoma",
+    "Metastatic Pancreatic Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8",
+    "Pancreatic Cancer Resectable",
+    "Unresectable Pancreatic Cancer",
+    "Advanced Solid Tumor; Pancreatic Adenocarcinoma; Malignant Melanoma (Cutaneous); Non-small Cell Lung Cancer (NSCLC)",
+    "Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage II Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer",
+    "Pancreatic Ductal Carcinoma; Advanced Cancer; Epithelial Tumor",
+    "Multiple Cancers (Pancreatic, Lung, Esophagogastric, Colorectal, Breast)",
+    "Locally Advanced Pancreatic Cancer",
+    "Acute Pancreatitis",
+    "Metastatic Pancreatic Cancer; Pancreatic Cancer",
+    "Pancreatic Cancer; Metastasis; Surgery; Oligometastatic Disease",
+    "Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage II Pancreatic Cancer; Stage III Pancreatic Cancer",
+    "Stage IV Pancreatic Cancer",
+    "Non-Resectable Pancreas Carcinoma",
+    "Locally Advanced Pancreatic Adenocarcinoma; Chemotherapy Effect; Borderline Resectable Pancreatic Adenocarcinoma; Pancreatectomy",
+    "Pancreatic Ductal Adenocarcinoma; Resectable Pancreatic Ductal Adenocarcinoma; Borderline Resectable Pancreatic Ductal Adenocarcinoma; Locally Advanced Pancreatic Ductal Adenocarcinoma",
+    "Pancreatic Cancer; Unresectable Pancreatic Cancer; Metastatic Pancreatic Cancer; KRAS P.G12C",
+    "Ductal Adenocarcinoma of Pancreas; Adenocarcinoma of Ampulla",
+    "Resectable Pancreatic Cancer",
+    "Pancreatic Carcinoma",
+    "Carcinoma, Pancreatic Ductal; Prognosis",
+    "Colorectal Cancer; Cancer of Pancreas; Pancreatic Neoplasm; Malignant Neoplasm of Large Intestine; Malignant Tumor of Colon; Colon Carcinoma; Cancer of Colon; Pancreatic Cancer",
+    "Cancer of Pancreas; Unresectable Pancreatic Cancer; Chemotherapy Effect; SBRT",
+    "Pancreatic Adenocarcinoma Treatment",
+    "Post-ERCP Acute Pancreatitis",
+    "Advanced Pancreatic Carcinoma",
+    "Pancreas Adenocarcinoma; Borderline Resectable Pancreatic Adenocarcinoma; Locally Advanced Pancreatic Adenocarcinoma",
+    "Gastric and Pancreatic Cancer",
+    "Pancreatic Ductal Adenocarcinoma (PDAC)",
+    "Pancreatic Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Pancreatic Diseases; Digestive System Diseases; Endocrine System Diseases; Gemcitabine; Antimetabolites, Antineoplastic",
+    "Pancreatitis",
+    "Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Resectable Pancreatic Adenocarcinoma",
+    "Pancreatic Cancer, Adult",
+    "Pancreatic Cancer; Metastatic Pancreatic Cancer"
+  ],
+  "Skin": [
+    "Melanoma",
+    "Psoriasis",
+    "Atopic Dermatitis",
+    "Acne Vulgaris",
+    "Psoriasis Vulgaris",
+    "Malignant Melanoma",
+    "Metastatic Melanoma",
+    "Rosacea",
+    "Plaque Psoriasis",
+    "Head and Neck Squamous Cell Carcinoma",
+    "Esophageal Squamous Cell Carcinoma",
+    "Acne",
+    "Melanoma (Skin)",
+    "Basal Cell Carcinoma",
+    "Actinic Keratosis",
+    "Squamous Cell Carcinoma of the Head and Neck",
+    "Dermatitis, Atopic",
+    "Squamous Cell Carcinoma of Head and Neck",
+    "Chronic Plaque Psoriasis",
+    "Uveal Melanoma",
+    "Scalp Psoriasis",
+    "Head and Neck Squamous Cell Carcinoma (HNSCC)",
+    "Malignant Melanoma, Neoplasms",
+    "Melanoma Stage III; Melanoma Stage IV",
+    "Papulopustular Rosacea",
+    "Squamous Cell Carcinoma",
+    "Advanced Solid Tumor; Pancreatic Adenocarcinoma; Malignant Melanoma (Cutaneous); Non-small Cell Lung Cancer (NSCLC)",
+    "Skin and Connective Tissue Diseases",
+    "Malignant Melanoma Stage III",
+    "Melanoma with Brain Metastases",
+    "Locally Advanced Head and Neck Squamous Cell Carcinoma",
+    "Advanced Solid Tumors; Metastatic Melanoma",
+    "Skin Cancer",
+    "Atrophic Acne Scar",
+    "Moderate to Severe Plaque Psoriasis",
+    "Moderate-to-Severe Atopic Dermatitis",
+    "Esophageal Squamous Cell Carcinoma; Oligometastatic Disease; Radiotherapy",
+    "Dermatitis Atopic",
+    "Atopic Dermatitis (AD)",
+    "Non-Small Cell Lung Cancer; Carcinoma, Squamous Cell; Adenocarcinoma",
+    "Oral Squamous Cell Carcinoma",
+    "Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma",
+    "Nail Psoriasis",
+    "Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC V8; Clinical Stage IV Cutaneous Melanoma AJCC V8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC V8; Pathologic Stage IIIA Cutaneous Melanoma AJCC V8; Pathologic Stage IIIB Cutaneous Melanoma AJCC V8; Pathologic Stage IIIC Cutaneous Melanoma AJCC V8; Pathologic Stage IIID Cutaneous Melanoma AJCC V8; Pathologic Stage IV Cutaneous Melanoma AJCC V8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC V8; Stage III Renal Cell Cancer AJCC V8; Stage IIIA Lung Cancer AJCC V8; Stage IIIB Lung Cancer AJCC V8; Stage IIIC Lung Cancer AJCC V8; Stage IV Lung Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8; Stage IVA Lung Cancer AJCC V8; Stage IVB Lung Cancer AJCC V8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma",
+    "Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7; Unresectable Melanoma",
+    "Advanced Melanoma",
+    "Psoriasis of Scalp",
+    "Malignant Melanoma of Soft Parts",
+    "Recurrent Melanoma; Stage IIIA Melanoma; Stage IIIB Melanoma; Stage IIIC Melanoma; Stage IV Melanoma",
+    "Melanoma; Skin Cancer",
+    "Metastatic Uveal Melanoma",
+    "Melanoma and Solid Tumors",
+    "Head and Neck Neoplasms; Carcinoma, Squamous Cell",
+    "Head and Neck Squamous Cell Cancer",
+    "Hand Eczema",
+    "Hypertrophic Scar",
+    "Metastatic Melanoma; Melanoma; BRAF-mutated Metastatic Melanoma; V600EBRAF-mutated Metastatic Melanoma",
+    "Metastatic NRAS Melanoma",
+    "Atopic Dermatitis; Eczema",
+    "Acne Rosacea",
+    "Neurodermatitis",
+    "BRAF v600 Mutated Metastatic Melanoma",
+    "Breast Cancer; Non-small Cell Lung Cancer; Melanoma; Brain Metastases",
+    "Acute Bacterial Skin and Skin Structure Infection",
+    "Chronic Hand Eczema",
+    "Eczema",
+    "Lung Adenocarcinoma and Squamous Cell Carcinoma",
+    "Advanced Esophageal Squamous Cell Carcinoma",
+    "Recurrent Melanoma; Stage IV Melanoma",
+    "Photodamaged Skin",
+    "Skin Rash with Lung Cancer",
+    "Esophagus Squamous Cell Carcinoma",
+    "Psoriasis Vulgaris; Psoriasis",
+    "Chronic Actinic Dermatitis",
+    "Advanced Non-squamous Cell Non-small Cell Lung Cancer",
+    "Metastatic Head and Neck Squamous Cell Carcinoma",
+    "Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma",
+    "Squamous Cell Lung Carcinoma"
+  ],
+  "Uterus": [
+    "Endometrial Cancer",
+    "Endometriosis",
+    "Advanced Malignant Solid Neoplasm; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Malignant Solid Neoplasm; Malignant Female Reproductive System Neoplasm; Metastatic HER2-Negative Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Recurrent Endometrial Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Malignant Female Reproductive System Neoplasm; Recurrent Malignant Solid Neoplasm; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Unresectable HER2-Negative Breast Carcinoma; Unresectable Malignant Solid Neoplasm",
+    "Endometrial Hyperplasia",
+    "Uterine Fibroids",
+    "Endometrial Carcinoma",
+    "Endometrial Neoplasms",
+    "Endometriosis-related Pain",
+    "Heavy Menstrual Bleeding; Uterine Fibroids",
+    "Dysfunctional Uterine Bleeding",
+    "Atypical Endometrial Hyperplasia",
+    "Uterine Disorders",
+    "Uterine Cervical Neoplasms",
+    "Infertility and Endometriosis",
+    "Advanced Endometrial Cancer",
+    "Chronic Endometritis",
+    "Stage I Endometrial Cancer",
+    "Endometrial Neoplasms with Fertility Preservation",
+    "Endometrium Cancer",
+    "Endometriosis with Pain",
+    "Breast Cancer; Advanced Breast Cancer; Metastatic Breast Cancer; Endometrial Cancer",
+    "Ovarian Cancer; Endometrial Cancer",
+    "PIK3CA Mutation; Solid Tumor, Adult; HER2-negative Breast Cancer; Breast Cancer; Metastatic Breast Cancer; Advanced Breast Cancer; Unresectable Solid Tumor; Endometrial Cancer",
+    "Intrauterine Growth Restriction",
+    "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN",
+    "Renal Cell Carcinoma; Ovarian Carcinoma; Thyroid Carcinoma; Breast Carcinoma; Endometrium Carcinoma"
+  ],
+    "Breast": [
+      "Breast Cancer",
+      "Metastatic Breast Cancer",
+      "Breast Neoplasms",
+      "Advanced Breast Cancer",
+      "Triple Negative Breast Cancer",
+      "Breast Cancer Female",
+      "Breast Neoplasm",
+      "Neoplasms, Breast",
+      "Early Breast Cancer",
+      "HER2-positive Breast Cancer",
+      "Breast Cancer Metastatic",
+      "Female Breast Neoplasm",
+      "Triple-negative Breast Cancer",
+      "Breast Cancer; Metastatic Breast Cancer",
+      "Breast Cancer Stage IV",
+      "Advanced Breast Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Prostate Carcinoma; Advanced Sarcoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Recurrent Adult Soft Tissue Sarcoma; Recurrent Breast Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Prostate Carcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8",
+      "Triple Negative Breast Neoplasms",
+      "Breast Carcinoma",
+      "Breast Cancer; HER2-positive Breast Cancer",
+      "Advanced Malignant Solid Neoplasm; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Malignant Solid Neoplasm; Malignant Female Reproductive System Neoplasm; Metastatic HER2-Negative Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Recurrent Endometrial Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Malignant Female Reproductive System Neoplasm; Recurrent Malignant Solid Neoplasm; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Unresectable HER2-Negative Breast Carcinoma; Unresectable Malignant Solid Neoplasm",
+      "Breast Neoplasms with Metastasis",
+      "Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer",
+      "Triple-Negative Breast Cancer",
+      "Early-stage Breast Cancer",
+      "ER-Positive HER2-Negative Breast Cancer",
+      "Advanced or Metastatic Breast Cancer",
+      "Tubular Breast Cancer Stage II; Mucinous Breast Cancer Stage II; Breast Cancer Female NOS; Invasive Ductal Breast Cancer; Tubular Breast Cancer Stage III; HER-2 Positive Breast Cancer; Inflammatory Breast Cancer Stage IV; Inflammatory Breast Cancer",
+      "Breast and Ovarian Cancer",
+      "Multiple Cancers (Pancreatic, Lung, Esophagogastric, Colorectal, Breast)",
+      "Lactation and Breastfeeding with Drug Exposure",
+      "Metastatic ER-positive/HER2-negative Breast Cancer",
+      "Malignant Neoplasm of Breast",
+      "HR+/HER2- Locally Advanced, Metastatic Breast Cancer",
+      "Metastatic Breast Cancer; Advanced Breast Cancer; Quality of Life; Toxicity; Older Patients",
+      "Metastatic Breast Cancer; ER+ Breast Cancer; Advanced Breast Cancer",
+      "Advanced Breast Cancer; Metastatic Breast Cancer",
+      "Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer",
+      "Locally Advanced or Metastatic Breast Cancer",
+      "Locally Advanced (Inoperable) or Metastatic Breast Cancer",
+      "Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8",
+      "HER2 Positive Breast Cancer",
+      "HER2+ Breast Cancer",
+      "Advanced Metastatic Breast Cancer",
+      "HER2-positive Breast Cancer with Brain Metastases",
+      "HER2-positive Metastatic Breast Cancer",
+      "Hormone Receptor Positive Advanced Breast Cancer",
+      "Breast Neoplasms; Breast Cancer",
+      "Invasive Breast Cancer",
+      "Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer",
+      "Early Stage Breast Cancer",
+      "Breast Cancer; Breast Neoplasms",
+      "Breast Cancer; Metastatic Cancer",
+      "Triple Negative Breast Cancer (TNBC)",
+      "Breast Cancer; Malignant Neoplasm of Breast",
+      "Triple-negative Breast Cancer; TNBC - Triple-Negative Breast Cancer",
+      "HR Positive HER2 Negative Advanced Breast Cancer",
+      "HR+/HER2- Advanced Breast Cancer; Targeted Therapy",
+      "Breastfeeding",
+      "HR+/HER2- Advanced/Metastatic Breast Cancer",
+      "Breast Cancer; Breast Cancer Stage IV; Metastatic Breast Cancer",
+      "Breast Cancer; Gynecologic Cancer; HNSCC; Solid Tumors, Adult",
+      "TNBC - Triple-Negative Breast Cancer",
+      "PIK3CA-Mutated Breast Cancer",
+      "HER-2 Positive Breast Cancer",
+      "Neoplasms; Breast Neoplasms",
+      "HER2-negative Breast Cancer",
+      "Carcinoma Breast Stage IV",
+      "Breast Cancer with Heart Failure",
+      "Breast Inflammatory Carcinoma; Locally Advanced Breast Carcinoma; Metastatic Breast Carcinoma; Stage III Breast Cancer AJCC v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7",
+      "Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Invasive Breast Carcinoma; Locally Advanced HER2-Positive Breast Carcinoma; Metastatic HER2-Positive Breast Carcinoma; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8",
+      "Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC V8; Clinical Stage IV Cutaneous Melanoma AJCC V8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC V8; Pathologic Stage IIIA Cutaneous Melanoma AJCC V8; Pathologic Stage IIIB Cutaneous Melanoma AJCC V8; Pathologic Stage IIIC Cutaneous Melanoma AJCC V8; Pathologic Stage IIID Cutaneous Melanoma AJCC V8; Pathologic Stage IV Cutaneous Melanoma AJCC V8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC V8; Stage III Renal Cell Cancer AJCC V8; Stage IIIA Lung Cancer AJCC V8; Stage IIIB Lung Cancer AJCC V8; Stage IIIC Lung Cancer AJCC V8; Stage IV Lung Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8; Stage IVA Lung Cancer AJCC V8; Stage IVB Lung Cancer AJCC V8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma",
+      "Breast Cancer Stage II-III",
+      "Metastatic Breast Cancer; ER-positive Breast Cancer; Luminal B; Her2 Enriched; Basal Like",
+      "Metastatic HER2-negative Breast Cancer",
+      "Recurrent Breast Cancer",
+      "Breast Cancer; Osteoporosis",
+      "Hormone-Receptor Positive Breast Carcinoma",
+      "Breast Cancer, Familial Male; Radiotherapy; Complications; Chemotherapeutic Toxicity; Immune Checkpoint Inhibitor; CDK4/6 Inhibitor; Trastuzumab; Pertuzumab; PARP Inhibitor",
+      "ER+ HER2- Advanced Breast Cancer",
+      "Advanced Hormone Receptor Positive Breast Cancer",
+      "Advanced Breast Cancer; Female Breast Cancer",
+      "Breast Cancer Invasive",
+      "Metastatic Triple Negative Breast Cancer",
+      "Hormone Receptor Positive HER-2 Negative Breast Cancer",
+      "Hormone Receptor Positive Breast Cancer; Metastatic Breast Cancer; Hormone Receptor Negative Breast Cancer",
+      "Breast Neoplasm Malignant Female",
+      "HR+/HER2- Breast Cancer",
+      "Breast Cancer; HER2-positive Breast Cancer; ER Positive Breast Cancer; PR-Positive Breast Cancer",
+      "BREAST CANCER",
+      "Breast Cancer; Hormone Receptor Positive Tumor",
+      "Breast Cancer; Neoplasm Metastasis",
+      "Breast, Prostate, and Ovarian Cancers",
+      "Breast Cancer; Triple Negative Breast Cancer (TNBC); Early Stage Breast Cancer; Immunotherapy; Probiotic",
+      "Hormone Receptor Positive, HER2-negative, Advanced Breast Cancer",
+      "HR-positive, HER2-negative Advanced Breast Cancer",
+      "Breast Cancer with Hand-Foot Syndrome",
+      "Metastatic ER+ Her2- Breast Cancer; Postmenopausal",
+      "Breast and Lung Cancer",
+      "HER2-positive Breast Cancer; Postmenopausal; Metastatic Breast Cancer",
+      "Breast Cancer; Metastatic Breast Cancer; Hormone Receptor-positive Breast Cancer; HER2-negative Breast Cancer",
+      "Breast Cancer with Neutropenia",
+      "Breast Cancer; Metastasis",
+      "Metastatic Breast Cancer; Breast Cancer",
+      "Metastatic Breast Cancer; ER Positive Breast Cancer; HER2-negative Breast Cancer",
+      "Metastatic Breast Cancer; Estrogen Receptor Positive Tumor; Breast Cancer Nos Premenopausal",
+      "Breast Cancer; Neoadjuvant Chemotherapy",
+      "Breast Cancer; Hormone Receptor-positive Breast Cancer; Hormone Therapy",
+      "Metastatic Breast Cancer; Locally Advanced Breast Cancer",
+      "Metastatic Castration-Resistant Prostate Cancer; Metastatic Breast Cancer; Non-small Cell Lung Cancer; Advanced Solid Tumors",
+      "HER2 Negative Breast Cancer",
+      "Geriatric Breast Cancer CDK4/6 Inhibitor Study",
+      "Breast Cancer; Non-small Cell Lung Cancer; Melanoma; Brain Metastases",
+      "HER2+ Metastatic Breast Cancer",
+      "HER-2 Positive Breast Cancer; Estrogen Receptor Positive Breast Cancer",
+      "Metastatic Breast Cancer; Locally Advanced Breast Cancer; Advanced Breast Cancer; BRCA2 Mutation; BRCA1 Mutation",
+      "Metastatic Breast Cancer; Recurrent Breast Cancer",
+      "Metastatic Breast Cancer; Tumor; Muscle Neoplasms; Chronic Pain",
+      "Breast Cancer; Neoplasms; Breast Diseases",
+      "Breast Cancer with Brain Metastases",
+      "Primary Breast Cancer",
+      "Hormone-receptor-positive HER2-negative Breast Cancer",
+      "Metastatic ER-Positive Breast Cancer",
+      "Stage IV Hormone Receptor Positive HER2 Negative Breast Cancer",
+      "Estrogen Receptor-positive Breast Cancer; HER2-negative Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer",
+      "Breast Cancer; Breast Neoplasm",
+      "Estrogen Receptor-positive Breast Cancer",
+      "Breast Cancer; Breast Carcinoma; Cancer of Breast; Malignant Tumor of Breast",
+      "Breast Cancer; Breast Carcinoma; Breast Neoplasms; Breast Tumors; Cancer of Breast",
+      "Breast Cancer Metastatic; Hormone Receptor Positive Malignant Neoplasm of Breast",
+      "Breast Cancer; Advanced Breast Cancer; Metastatic Breast Cancer; Endometrial Cancer",
+      "Advanced Breast and Ovarian Cancer",
+      "Breast Cancer Triple Negative",
+      "Breast Cancer (ER+/HER2-)",
+      "Hormone Receptor-positive Breast Cancer",
+      "Breast Cancer Adjuvant Therapy",
+      "Hormone Receptor-positive Metastatic Breast Cancer; HER2-negative Metastatic Breast Cancer",
+      "Advanced or Metastatic ER+ Breast Cancer",
+      "Breast Cancer, Metastatic Breast Cancer",
+      "Early Stage HER2+ Breast Cancer",
+      "Stage IV (Metastatic) Breast Cancer; Metastatic Breast Cancer; ER Positive Breast Cancer; PR-Positive Breast Cancer; HER2-negative Breast Cancer; Invasive Breast Cancer",
+      "Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer",
+      "Advanced Breast Cancer; Treatment; HR Low/HER2 Negative",
+      "Advanced HR+/HER2- Breast Cancer",
+      "Breast Cancer; Chemotherapy-induced Alopecia",
+      "Advanced Breast Cancer; Breast Cancer",
+      "PIK3CA Mutation; Solid Tumor, Adult; HER2-negative Breast Cancer; Breast Cancer; Metastatic Breast Cancer; Advanced Breast Cancer; Unresectable Solid Tumor; Endometrial Cancer",
+      "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN",
+      "Triple-Negative Breast Carcinoma",
+      "Breast Cancer; Cancer of Breast; Breast Neoplasms; Cancer of the Breast",
+      "Breast Cancer; Cancer",
+      "Renal Cell Carcinoma; Ovarian Carcinoma; Thyroid Carcinoma; Breast Carcinoma; Endometrium Carcinoma",
+      "Hormone Receptor-Positive Breast Cancer",
+      "Advanced/Metastatic Breast Cancer, HER2-Negative",
+      "Breast Cancer; Chemotherapy Effect",
+      "Early Stage Triple-Negative Breast Carcinoma",
+      "Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8; Metastatic Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Prognostic Stage IV Breast Cancer AJCC v8",
+      "Breast Adenocarcinoma; Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIC Breast Cancer; Triple-Negative Breast Carcinoma",
+      "Advanced Cancer; Metastatic Cancer; Non-Hodgkin's Lymphoma; Metastatic Breast Cancer; Malignant Mesothelioma; Non-small Cell Lung Cancer",
+      "Breast Cancer (Various Types and Stages)"
+    ],
+      "Ovary/Fallopian Tube": [
+        "Ovarian Cancer",
+        "Polycystic Ovary Syndrome",
+        "Ovarian Neoplasms",
+        "Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer",
+        "Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer",
+        "Advanced Breast Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Prostate Carcinoma; Advanced Sarcoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Recurrent Adult Soft Tissue Sarcoma; Recurrent Breast Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Prostate Carcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8",
+        "Advanced Malignant Solid Neoplasm; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Malignant Solid Neoplasm; Malignant Female Reproductive System Neoplasm; Metastatic HER2-Negative Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Recurrent Endometrial Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Malignant Female Reproductive System Neoplasm; Recurrent Malignant Solid Neoplasm; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Unresectable HER2-Negative Breast Carcinoma; Unresectable Malignant Solid Neoplasm",
+        "Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma",
+        "Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma",
+        "Breast and Ovarian Cancer",
+        "Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity",
+        "Recurrent Ovarian Cancer",
+        "Ovarian Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Platinum-resistant Ovarian Cancer",
+        "Ovary Cancer",
+        "Platinum-resistant Ovarian Cancer",
+        "Premature Ovarian Failure",
+        "Polycystic Ovary Syndrome (PCOS)",
+        "Polycystic Ovarian Syndrome",
+        "Ovarian and Related Carcinomas",
+        "Ovarian and Peritoneal Cancer",
+        "Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Neoplasms",
+        "Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC V8; Clinical Stage IV Cutaneous Melanoma AJCC V8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC V8; Pathologic Stage IIIA Cutaneous Melanoma AJCC V8; Pathologic Stage IIIB Cutaneous Melanoma AJCC V8; Pathologic Stage IIIC Cutaneous Melanoma AJCC V8; Pathologic Stage IIID Cutaneous Melanoma AJCC V8; Pathologic Stage IV Cutaneous Melanoma AJCC V8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC V8; Stage III Renal Cell Cancer AJCC V8; Stage IIIA Lung Cancer AJCC V8; Stage IIIB Lung Cancer AJCC V8; Stage IIIC Lung Cancer AJCC V8; Stage IV Lung Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8; Stage IVA Lung Cancer AJCC V8; Stage IVB Lung Cancer AJCC V8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma",
+        "Breast, Prostate, and Ovarian Cancers",
+        "Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer; Ovarian Cancer",
+        "Epithelial Ovarian and Related Cancers",
+        "Platinum-resistant Ovarian Cancer; Platinum-refractory Ovarian Carcinoma; Platinum-Resistant Fallopian Tube Carcinoma; Platinum-Resistant Primary Peritoneal Carcinoma",
+        "Advanced Breast and Ovarian Cancer",
+        "Advanced Ovarian Cancer",
+        "Primary Ovarian Insufficiency",
+        "Ovarian and Peritoneal Carcinoma",
+        "Ovarian Epithelial Cancer",
+        "Ovarian Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer",
+        "Ovarian Cancer and Related Malignancies",
+        "Ovarian Cancer; Endometrial Cancer",
+        "Ovarian and Related Cancers",
+        "Renal Cell Carcinoma; Ovarian Carcinoma; Thyroid Carcinoma; Breast Carcinoma; Endometrium Carcinoma"
+      ],
+        "Cervix": [
+          "Cervical Cancer",
+          "Advanced Cancer; Metastatic Cervical Cancer",
+          "Cervical Radiculopathy",
+          "Uterine Cervical Neoplasms",
+          "Cervical Pain",
+          "Cervical Intraepithelial Neoplasia"
+        ],
+          "CNS/Brain": [
+            "Multiple Sclerosis",
+            "Parkinson Disease",
+            "Neuroblastoma",
+            "Parkinson's Disease",
+            "Stroke",
+            "Epilepsy",
+            "Amyotrophic Lateral Sclerosis",
+            "Ischemic Stroke",
+            "Alzheimer's Disease",
+            "Alzheimer Disease",
+            "Brain and Central Nervous System Tumors",
+            "Primary Central Nervous System Lymphoma",
+            "Cerebral Palsy",
+            "Relapsing-Remitting Multiple Sclerosis",
+            "Glioblastoma",
+            "Relapsing Remitting Multiple Sclerosis",
+            "Acute Ischemic Stroke",
+            "Hepatic Encephalopathy",
+            "Traumatic Brain Injury",
+            "Relapsing Multiple Sclerosis",
+            "Glioma",
+            "Dementia",
+            "Cerebrovascular Accident",
+            "Amyotrophic Lateral Sclerosis (ALS)",
+            "Glioblastoma Multiforme",
+            "Relapsing-remitting Multiple Sclerosis",
+            "Central Nervous System Lymphoma",
+            "Intracerebral Hemorrhage",
+            "Advanced Parkinson's Disease",
+            "Idiopathic Parkinson's Disease",
+            "Acute Stroke",
+            "Brain Tumors",
+            "Stroke with Atrial Fibrillation",
+            "Brain Tumors; Central Nervous System Tumors",
+            "Amyotrophic Lateral Sclerosis; ALS",
+            "Brain Metastases",
+            "Cerebral Infarction",
+            "Seizures",
+            "Alzheimer Disease; Preclinical Alzheimer's Disease; Prodromal Alzheimer's Disease; Alzheimer's Disease (Incl Subtypes); Mild Cognitive Impairment",
+            "Chronic Stroke",
+            "Atrial Fibrillation and Stroke",
+            "Atrial Fibrillation; Stroke; Bleeding",
+            "Progressive Multiple Sclerosis",
+            "Stroke Rehabilitation",
+            "Meningioma",
+            "Relapsing Forms of Multiple Sclerosis",
+            "Melanoma with Brain Metastases",
+            "Agitation in Patients With Dementia of the Alzheimer's Type",
+            "Neuroblastoma Recurrent",
+            "HER2-positive Breast Cancer with Brain Metastases",
+            "Glioblastoma Multiforme; Gliosarcoma",
+            "Relapsing-Remitting Multiple Sclerosis; Multiple Sclerosis",
+            "Alzheimer Disease and Dementia",
+            "Secondary Progressive Multiple Sclerosis",
+            "Primary CNS Lymphoma",
+            "Ganglioneuroblastoma; Neuroblastoma",
+            "Malignant Glioma",
+            "Toxoplasmosis, Cerebral; HIV Infections",
+            "Focal Epilepsy",
+            "Brain and Central Nervous System Conditions",
+            "Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7; Unresectable Melanoma",
+            "Brain Tumor",
+            "Diabetes Mellitus with Stroke",
+            "Adult Patients With Newly Diagnosed or Relapsed or Refractory Primary Central Nervous System Lymphoma (PCNSL); Or Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL)",
+            "Recurrent Glioblastoma",
+            "Glioblastoma, Adult",
+            "Glioblastoma; Recurrent Disease; Recurrent Glioblastoma",
+            "CVA (Cerebrovascular Accident); Stroke; Upper Extremity Paresis",
+            "CNS Embryonal Tumors",
+            "Malignant Gliomas",
+            "Low-Grade Glioma",
+            "CNS Lymphoma",
+            "Recurrent CNS Tumors",
+            "Multiple Sclerosis; Healthy",
+            "Neuroblastoma and Lymphoma",
+            "Non-Epileptic Seizures",
+            "Breast Cancer; Non-small Cell Lung Cancer; Melanoma; Brain Metastases",
+            "Transient Ischemic Attack and Minor Ischemic Stroke",
+            "Cerebrovascular Disease",
+            "Cerebrovascular Disorders",
+            "Brain Death",
+            "Recurrent Neuroblastoma; Stage 2A Neuroblastoma; Stage 2B Neuroblastoma; Stage 3 Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma",
+            "Cerebral Small Vessel Disease",
+            "Epilepsy and Cognition Disorders",
+            "Breast Cancer with Brain Metastases",
+            "Gliomas and Neuroglial Tumors",
+            "Gliomas and Neuronal Tumors",
+            "Depression; Relapsing-remitting Multiple Sclerosis",
+            "Diffuse Intrinsic Pontine Glioma",
+            "Primary Progressive Multiple Sclerosis",
+            "Brain Neoplasms",
+            "Refractory or Recurrent Neuroblastoma in Children",
+            "Ganglioneuroblastoma, Nodular; Neuroblastoma",
+            "Pediatric Low-grade Glioma",
+            "Cerebrovascular and Cognitive Disorders",
+            "Stroke, Ischemic",
+            "Stroke, Cardiovascular",
+            "Stroke Patients",
+            "Early Onset Alzheimer Disease",
+            "Focal Onset Seizure",
+            "Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8; Metastatic Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Prognostic Stage IV Breast Cancer AJCC v8",
+            "Recurrent or Progressive Glioblastoma",
+            "CNS Tumors and Neoplasms",
+            "Adult Malignant Gliomas",
+            "Parkinson Disease with Depression",
+            "Parkinsonian Signs in Older Persons",
+            "Huntington Disease",
+            "Leptomeningeal Metastasis"
+          ],
+
+            "Liver": [
+              "Hepatocellular Carcinoma",
+              "Liver Cancer",
+              "Carcinoma, Hepatocellular",
+              "Hepatic Encephalopathy",
+              "Hepatitis C",
+              "Liver Transplantation",
+              "Biliary Tract Cancer",
+              "Chronic Hepatitis C",
+              "Cholangiocarcinoma",
+              "Hepatic Impairment",
+              "Chronic Hepatitis B",
+              "Primary Biliary Cirrhosis",
+              "Fatty Liver",
+              "Liver Cirrhosis",
+              "Hepatic Insufficiency",
+              "Alcoholic Hepatitis",
+              "Cirrhosis",
+              "Non-alcoholic Fatty Liver Disease",
+              "Advanced Hepatocellular Carcinoma",
+              "Intrahepatic Cholangiocarcinoma",
+              "Hepatocellular Carcinoma (HCC)",
+              "Colorectal Cancer; Liver Metastases",
+              "Hepatitis B",
+              "Hepatocellular Carcinoma Non-resectable",
+              "Liver Diseases",
+              "Liver Transplant",
+              "Chronic Hepatitis C Infection",
+              "Childhood Liver Malignancies",
+              "Non-Alcoholic Fatty Liver Disease",
+              "Primary Hepatocellular Carcinoma",
+              "Hepatoblastoma",
+              "Decompensated Cirrhosis",
+              "Nonalcoholic Steatohepatitis",
+              "Liver Disease",
+              "Advanced Biliary Tract Cancer",
+              "Biliary Tract Carcinoma",
+              "Biliary Tract Neoplasms",
+              "Liver Fibrosis",
+              "HIV and Hepatitis C Coinfection",
+              "Non-Alcoholic Steatohepatitis",
+              "Colorectal Cancer; Liver Metastasis",
+              "Colorectal Cancer with Liver Metastases",
+              "Liver Transplantation; Hepatocellular Carcinoma; Tumor Recurrence and Metastasis; Survival; Adjuvant Chemotherapy",
+              "Hepatic Carcinoma",
+              "Primary Biliary Cholangitis",
+              "Severe Alcoholic Hepatitis",
+              "Non-alcoholic Steatohepatitis",
+              "Hepatitis C Virus",
+              "Hepatopulmonary Syndrome",
+              "Unresectable Hepatocellular Carcinoma",
+              "Fatty Liver Disease",
+              "Decompensated Liver Cirrhosis",
+              "Metastatic Biliary Cancer",
+              "Biliary and Colorectal Neoplasms",
+              "Biliary Atresia",
+              "Metastatic Biliary Tract Cancer",
+              "Primary Sclerosing Cholangitis",
+              "Colon Cancer Liver Metastasis",
+              "Colorectal Cancer; Cholangiocarcinoma",
+              "Hepatitis",
+              "Non Small Cell Lung Cancer; Hepatitis B",
+              "Metabolic Associated Fatty Liver Disease",
+              "Chronic Hepatitis D",
+              "Moderate Hepatic Impairment",
+              "Hepatitis D",
+              "Metastatic Colorectal Cancer; Metastatic Cancer to Liver",
+              "Colorectal Cancer with Liver Metastasis",
+              "Colorectal Cancer; Colorectal Liver Metastases",
+              "HIV; Hepatitis C",
+              "Colorectal Cancer Metastatic; Liver Metastasis Colon Cancer",
+              "Biliary Tract Cancers",
+              "Primary Biliary Cholangitis (PBC)",
+              "Chronic Hepatitis C Virus",
+              "Chronic Hepatitis D Infection",
+              "Biliary Liver Cirrhosis",
+              "Metastatic Colon Cancer to Liver",
+              "Liver Lymphoma; Mantle Cell Lymphoma",
+              "Resected Liver Metastases From Colorectal Cancer",
+              "Advanced Malignant Neoplasm; Colorectal Carcinoma Metastatic in the Liver; Metastatic Malignant Neoplasm in the Liver; Refractory Malignant Neoplasm",
+              "Recurrent Hepatitis C",
+              "Advanced Biliary Tract Carcinoma",
+              "Drug-Induced Liver Injury (DILI)",
+              "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN",
+              "Chronic Drug-induced Liver Injury",
+              "Parenteral Nutrition Associated Liver Disease",
+              "Human Immunodeficiency Virus; Hepatitis B, Chronic; Hepatitis C, Chronic"
+            ],
+              "Kidney": [
+                "Renal Cell Carcinoma",
+                "Carcinoma, Renal Cell",
+                "Kidney Transplantation",
+                "Chronic Kidney Disease",
+                "Metastatic Renal Cell Carcinoma",
+                "Kidney Cancer",
+                "Chronic Kidney Diseases",
+                "Renal Transplantation",
+                "Acute Kidney Injury",
+                "End Stage Renal Disease",
+                "Lupus Nephritis",
+                "Diabetic Nephropathy",
+                "Diabetic Nephropathies",
+                "Kidney Failure, Chronic",
+                "Renal Impairment",
+                "Renal Cell Cancer",
+                "Kidney Diseases",
+                "Advanced Renal Cell Carcinoma",
+                "Renal Failure",
+                "Kidney Transplant",
+                "Metastatic Renal Cell Carcinoma (mRCC)",
+                "Chronic Renal Failure",
+                "Kidney Neoplasms",
+                "Renal Insufficiency",
+                "Clear Cell Renal Cell Carcinoma",
+                "Renal Transplant",
+                "End-stage Renal Disease",
+                "Idiopathic Membranous Nephropathy",
+                "Chronic Renal Insufficiency",
+                "Type 2 Diabetes with Diabetic Nephropathy",
+                "Kidney Disease",
+                "Depression with Acute Kidney Injury",
+                "Chronic Kidney Disease With High Proteinuria",
+                "Chronic Kidney Disease and Hypertension",
+                "Secondary Hyperparathyroidism; Chronic Kidney Disease",
+                "Type 2 Diabetes; Diabetic Kidney Disease",
+                "Locally Advanced Papillary Renal Cell Carcinoma; Metastatic Papillary Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7; Type 1 Papillary Renal Cell Carcinoma; Type 2 Papillary Renal Cell Carcinoma; Unresectable Renal Cell Carcinoma",
+                "Cardiovascular Events; Type2 Diabetes; Renal Disease",
+                "Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma",
+                "Congenital Adrenal Hyperplasia",
+                "Glomerulonephritis",
+                "Membranous Glomerulonephritis",
+                "Nephrolithiasis",
+                "Nephrotic Syndrome",
+                "Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC V8; Clinical Stage IV Cutaneous Melanoma AJCC V8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC V8; Pathologic Stage IIIA Cutaneous Melanoma AJCC V8; Pathologic Stage IIIB Cutaneous Melanoma AJCC V8; Pathologic Stage IIIC Cutaneous Melanoma AJCC V8; Pathologic Stage IIID Cutaneous Melanoma AJCC V8; Pathologic Stage IV Cutaneous Melanoma AJCC V8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC V8; Stage III Renal Cell Cancer AJCC V8; Stage IIIA Lung Cancer AJCC V8; Stage IIIB Lung Cancer AJCC V8; Stage IIIC Lung Cancer AJCC V8; Stage IV Lung Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8; Stage IVA Lung Cancer AJCC V8; Stage IVB Lung Cancer AJCC V8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma",
+                "Diabetic Nephropathy Type 2",
+                "Renal Colic",
+                "Renal Function",
+                "Primary Membranous Nephropathy",
+                "Chronic Kidney Failure and Transplantation",
+                "Heart Failure; Chronic Kidney Disease",
+                "ccRCC; RCC; Kidney Cancer; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma",
+                "Clear Cell Metastatic Renal Cell Carcinoma",
+                "Clear-cell Metastatic Renal Cell Carcinoma",
+                "Immunoglobulin A Nephropathy",
+                "Metastatic Kidney Medullary Carcinoma; Metastatic Renal Cell Carcinoma; SMARCB1 Negative; Stage III Renal Cell Cancer AJCC V8; Stage IV Renal Cell Cancer AJCC V8",
+                "Chronic Renal Disease",
+                "Nephrotoxicity",
+                "Nephropathic Cystinosis",
+                "Metastatic Renal Cancer",
+                "Secondary Hyperparathyroidism in End Stage Renal Disease",
+                "Renal Pelvis and Ureter Urothelial Carcinoma",
+                "Primary IgA Nephropathy",
+                "Kidney Transplant Recipients",
+                "Kidney Transplant Rejection",
+                "End-stage Kidney Disease",
+                "End-Stage Renal Disease",
+                "Advanced Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma",
+                "Anemia of Chronic Kidney Disease",
+                "Renal Cell Carcinoma; Ovarian Carcinoma; Thyroid Carcinoma; Breast Carcinoma; Endometrium Carcinoma",
+                "Renal Cell Carcinoma; Kidney Cancer",
+                "Renal Disease",
+                "Chronic Kidney Failure",
+                "Renal Cancer"
+              ],
+
+                "Peripheral Nervous System": [
+                  "Chemotherapy-induced Peripheral Neuropathy",
+                  "Peripheral Neuropathy",
+                  "Diabetic Peripheral Neuropathy",
+                  "Trigeminal Neuralgia",
+                  "Diabetic Neuropathy, Painful",
+                  "Peripheral Diabetic Neuropathy",
+                  "Diabetic Polyneuropathy",
+                  "Nonarteritic Anterior Ischemic Optic Neuropathy",
+                  "Chemotherapy Induced Peripheral Neuropathy",
+                  "Diabetic Neuropathy",
+                  "Painful Diabetic Neuropathy",
+                  "Optic Neuritis"
+                ],
+                  "Vulva/Vagina": [
+                    "Vaginal Disease"
+                  ],
+                    "Bladder/Urinary Tract": [
+                      "Bladder Cancer",
+                      "Urothelial Carcinoma; Bladder Cancer; Urinary Bladder Neoplasms",
+                      "Urinary Tract Cancers",
+                      "Urothelial Carcinoma",
+                      "Overactive Bladder",
+                      "Urinary Bladder Neoplasms",
+                      "Urinary Tract Infection",
+                      "Urothelial Cancer",
+                      "Metastatic Urothelial Cancer",
+                      "Interstitial Cystitis",
+                      "Urinary Tract Infections",
+                      "Muscle Invasive Bladder Cancer; High Risk Urothelial Carcinoma of the Upper Urinary Tracts",
+                      "Gallbladder Neoplasms",
+                      "Non-Muscle Invasive Bladder Cancer",
+                      "Lower Urinary Tract Symptoms",
+                      "Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma",
+                      "Non-Muscle Invasive Bladder Urothelial Carcinoma",
+                      "Non-muscle Invasive Bladder Cancer",
+                      "Bladder Urothelial Carcinoma",
+                      "Muscle Invasive Bladder Cancer",
+                      "Non-small Cell Lung Carcinoma; Urothelial Carcinoma; Gastrointestinal Carcinoma, Non-colon; Upper Aerodigestive Tract Carcinoma",
+                      "Upper Urinary Tract Urothelial Carcinoma",
+                      "Urethral Stricture",
+                      "Renal Pelvis and Ureter Urothelial Carcinoma",
+                      "Lung Cancer; Solid Tumor; Gastric Cancer; Urothelial Cancer; Endometrial Cancer; Multiple Myeloma; Myeloproliferative Neoplasms; Breast Cancer; Cholangiocarcinoma; UC; MPN"
+                    ]
+              
+              }

data/tahoe_drugs_clinical_trials.csv

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+size 16008886

data/tahoe_drugs_pubchem_trials_info.csv

@@ -0,0 +1,697 @@
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data_for_classifier/assoc_drug_organ.tsv

@@ -0,0 +1,523 @@
+drug_organ	is_associated_with_indication
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data_for_classifier/tahoe_drug_ae_seriousness_ratio.csv

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+drug_name,mean_serious_flag
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data_for_classifier/tahoe_drug_ae_severity_score.csv

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+drug_name,ae_severity_score
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