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William James and British thought: then and now
David E. Leary
Journal: BJPsych Bulletin / Volume 44 / Issue 2 / April 2020
Published online by Cambridge University Press: 16 September 2019, pp. 53-56
Print publication: April 2020
The American psychologist and philosopher William James drew inspiration from British evolutionary theory, neurology, psychiatry, psychology and philosophy. Trained in anatomy, physiology and medicine, he developed a physiological psychology that offered acute analyses of consciousness and of the relations between mind and brain, habit and thought, cognition and emotion and other aspects of psychology. One of his insights, regarding the relation between attention and will, was based upon his own experience of panic anxiety, which was resolved through his reading of several British authors. The story of his psychiatric experience, practical response and later theoretical conclusion offers a potential contribution to contemporary therapeutic practice.
31 Intracranial growing teratoma syndrome (IGTS): An international retrospective study
George Michaiel, Douglas Strother, Nicholas Gottardo, Ute Bartels, Hallie Coltin, David D. Eisenstat, Juliette Hukin, Donna L. Johnston, Beverly Wilson, Shayna Zelcer, Jordan R. Hansford, Olivia Wells, Mohamed S. AbdelBaki, Mohammad H. Abu-Arja, Kristina A. Cole, Girish Dhall, Paul G. Fisher, Lindsey Hoffman, Sarah E.S. Leary, Emily E. Owens Pickle, Natasha P. Smiley, Amy Smith, Anna Vinitsky, Nicholas A. Vitanza, Avery Wright, Kee K. Yeo, Lionel M.L. Chow, Maria Kirby, Santosh Valvi, Magimairajan I. Vanan, Grace Wong, David Ziegler, Eric Bouffet, Lucie Lafay-Cousi
Journal: Canadian Journal of Neurological Sciences / Volume 45 / Issue S3 / June 2018
Published online by Cambridge University Press: 27 July 2018, p. S13
BACKGROUND: IGTS is a rare phenomenon of paradoxical germ cell tumor (GCT) growth during or following treatment despite normalization of tumor markers. We sought to evaluate the frequency, clinical characteristics and outcome of IGTS in patients in 21 North-American and Australian institutions. METHODS: Patients with IGTS diagnosed from 2000-2017 were retrospectively evaluated. RESULTS: Out of 739 GCT diagnoses, IGTS was identified in 33 patients (4.5%). IGTS occurred in 9/191 (4.7%) mixed-malignant GCTs, 4/22 (18.2%) immature teratomas (ITs), 3/472 (0.6%) germinomas/germinomas with mature teratoma, and in 17 secreting non-biopsied tumours. Median age at GCT diagnosis was 10.9 years (range 1.8-19.4). Male gender (84%) and pineal location (88%) predominated. Of 27 patients with elevated markers, median serum AFP and Beta-HCG were 70 ng/mL (range 9.2-932) and 44 IU/L (range 4.2-493), respectively. IGTS occurred at a median time of 2 months (range 0.5-32) from diagnosis, during chemotherapy in 85%, radiation in 3%, and after treatment completion in 12%. Surgical resection was attempted in all, leading to gross total resection in 76%. Most patients (79%) resumed GCT chemotherapy/radiation after surgery. At a median follow-up of 5.3 years (range 0.3-12), all but 2 patients are alive (1 succumbed to progressive disease, 1 to malignant transformation of GCT). CONCLUSION: IGTS occurred in less than 5% of patients with GCT and most commonly after initiation of chemotherapy. IGTS was more common in patients with IT-only on biopsy than with mixed-malignant GCT. Surgical resection is a principal treatment modality. Survival outcomes for patients who developed IGTS are favourable.
Drones on ice: an assessment of the legal implications of the use of unmanned aerial vehicles in scientific research and by the tourist industry in Antarctica
David Leary
Journal: Polar Record / Volume 53 / Issue 4 / July 2017
Published online by Cambridge University Press: 22 May 2017, pp. 343-357
Unmanned aerial vehicles (UAVs), also known as drones, are used in scientific research and a diverse range of other applications across the globe. They are also being used increasingly for scientific research in Antarctica and to a lesser extent by tourists visiting the world's last great frontier tourist destination. Their use in scientific research in Antarctica offers many benefits to science and if used responsibly may be less invasive than other research techniques, offering a rich source of new scientific data. For tourists, UAVs also offer unique aerial photographic perspectives on Antarctica — the ultimate holiday snap shot. Concerns have been raised about the safety of drone use in the harsh and unpredictable Antarctic conditions, as well as possible environmental impacts. This paper considers these issues and the emerging regulatory response to drone use in Antarctica focusing on the Antarctic Unmanned Aerial Systems (UAS) Operator's Handbook, which provides guidelines to national Antarctic programmes on the use of UAVs in the Antarctic Treaty area, and the temporary ban on use of drones by tourists imposed by the International Association of Antarctica Tour Operators (IAATO). Both measures arguably constitute a good first response to this emerging issue, although more still needs to be done.
Multi-Dimensional Machine Learning Aided Analysis of a Nickel-Based Superalloy
David Rossouw, Robert Krakow, Zineb Saghi, Catriona S M Yeoh, Pierre Burdet, Rowan K Leary, Paul A Midgley
Journal: Microscopy and Microanalysis / Volume 21 / Issue S3 / August 2015
Published online by Cambridge University Press: 23 September 2015, pp. 2173-2174
The Dark Side of EDX Tomography: Modeling Detector Shadowing to Aid 3D Elemental Signal Analysis
Catriona S.M. Yeoh, David Rossouw, Zineb Saghi, Pierre Burdet, Rowan K. Leary, Paul A. Midgley
Journal: Microscopy and Microanalysis / Volume 21 / Issue 3 / June 2015
A simple model is proposed to account for the loss of collected X-ray signal by the shadowing of X-ray detectors in the scanning transmission electron microscope. The model is intended to aid the analysis of three-dimensional elemental data sets acquired using energy-dispersive X-ray tomography methods where shadow-free specimen holders are unsuitable or unavailable. The model also provides a useful measure of the detection system geometry.
By Federica Agosta, Alberto Albanese, Timothy J. Amrhein, A. M. Barrett, Walter S. Bartynski, Felix Benninger, Thomas Brandt, Andrew G. Burke, Michelle Cameron, Elisa Canu, Louis R. Caplan, Christine M. Carr, Daniel J. A. Connolly, Firouz Daneshgari, John DeLuca, Marianne de Visser, Marianne Dieterich, Antonio E. Elia, Joseph H. Feinberg, Massimo Filippi, Lauren C. Frey, Gaëtan Garraux, Andrea Ginestroni, Peter J. Goadsby, Bronwyn E. Hamilton, Simon J. Hickman, Holly E. Hinson, Jon P. Jennings, Jan Kassubek, Horacio Kaufmann, David M. Kaylie, Joanna Kitley, Vladimir S. Kostic, C. T. Paul Krediet, Megan C. Leary, Farooq H. Maniyar, Ken R. Maravilla, Mario Mascalchi, Rajarshi Mazumder, Priyesh Mehta, Jacqueline A. Palace, Raj M. Paspulati, Christopher A. Potter, Angelo Quattrini, Louis P. Riccelli, Nilo Riva, Maria A. Rocca, Mirabelle B. Sajisevi, Richard Salazar-Montero, Nicholas D. Schiff, Jack H. Simon, Israel Steiner, Carl D. Stevens, Bart P. van de Warrenburg, Judith van Gaalen, William J. Weiner, Jane L. Weissman, Jay Yao, G. Bryan Young
Edited by Massimo Filippi, Jack H. Simon
Book: Imaging Acute Neurologic Disease
Published online: 05 October 2014
Print publication: 11 September 2014, pp vi-viii
Reducing Nascent Miconia (Miconia calvescens) Patches with an Accelerated Intervention Strategy Utilizing Herbicide Ballistic Technology
James Leary, Brooke V. Mahnken, Linda J. Cox, Adam Radford, John Yanagida, Teya Penniman, David C. Duffy, Jeremy Gooding
Journal: Invasive Plant Science and Management / Volume 7 / Issue 1 / March 2014
The miconia (Miconia calvescens) invasion of the East Maui Watershed (EMW) started from a single introduction over 40 yr ago, establishing a nascent patch network spread across 20,000 ha. In 2012, an accelerated intervention strategy was implemented utilizing the Herbicide Ballistic Technology (HBT) platform in a Hughes 500D helicopter to reduce target densities of seven nascent patches in the EMW. In a 14-mo period, a total of 48 interventions eliminated 4,029 miconia targets, with an estimated 33% increase in operations and 168% increase in recorded targets relative to the adjusted means from 2005 to 2011 data (prior to HBT adoption). This sequence of interventions covered a total net area of 1,138 ha, creating a field mosaic of overlapping search coverage (saturation) for each patch (four to eight interventions per patch). Target density reduction for each patch fit exponential decay functions (R 2 > 0.88, P < 0.05), with a majority of the target interventions spatially assigned to the highest saturation fields. The progressive decay in target density led to concomitant reductions in search efficiency (min ha−1) and herbicide use rate (grams ae ha−1) in subsequent interventions. Mean detection efficacy (± SE) between overlapping interventions (n = 41) was 0.62 ± 0.03, matching closely with the probability of detection for a random search operation and verifying imperfect (albeit precise) detection. The HBT platform increases the value of aerial surveillance operations with 98% efficacy in target elimination. Applying coverage saturation with an accelerated intervention schedule to known patch locations is an adaptive process for compensating imperfect detection and building intelligence with spatial and temporal relevance to the next operation.
The Marlborough Mound, Wiltshire. A Further Neolithic Monumental Mound by the River Kennet
Jim Leary, Matthew Canti, David Field, Peter Fowler, Peter Marshall, Gill Campbell
Journal: Proceedings of the Prehistoric Society / Volume 79 / December 2013
Recent radiocarbon dates obtained from two soil cores taken through the Marlborough Castle mound, Wiltshire, show the main body of it to be a contemporaneous monument to Silbury Hill, dating to the second half of the 3rd millennium cal bc. In light of these dates, this paper considers the sequence identified within the cores, which includes two possible flood events early in the construction of the mound. It also describes four cores taken through the surrounding ditch, as well as small-scale work to the north-east of the mound. The topographic location of the mound in a low-lying area and close to rivers and springs is discussed, and the potential for Late Neolithic sites nearby is set out, with the land to the south of the mound identified as an area for future research. The paper ends with the prospect that other apparent mottes in Wiltshire and beyond may well also have prehistoric origins
Greenland's new legislation on commercial and research-related use of biological resources: implications for the International Polar Year and later
Journal: Polar Record / Volume 44 / Issue 2 / April 2008
Published online by Cambridge University Press: 01 April 2008, pp. 97-106
New possibilities for economic development have been identified by the Greenland Home Rule Government in recent years. One of these is the potential for development of biotechnology based on Greenland's biodiversity. To ensure that Greenland shares in benefits derived from the exploitation of these resources the Home Rule Parliament recently enacted legislation on commercial and research-related use of biological resources that is premised on rights recognised by the 1992 Convention on Biological Diversity. This legislation represents the first law in an Arctic jurisdiction specifically to create a mechanism for access and benefit sharing in relation to Arctic genetic resources. The main area of research and commercial interest so far relates to potential developments in biotechnology from the microbial diversity of ikaite tufa columns located in the Ikka Fjord in southwest Greenland. The legislation seeks to provide a mechanism for regulating access to such biological resources and a means for Greenland to share in the potential benefits that may come from scientific research on them and subsequent commercialisation. Much research in Greenland now falls within the scope of this legislation. The purpose of this article is to explain the provisions of the legislation to the polar research community as well as to review its implications for research in the International Polar Year and later. The legislation imposes many new obligations on researchers in Greenland including obligations to obtain survey licences, obligations on reporting and the regulation of publication of scientific research. Commercially focussed research is also tightly regulated with a particular emphasis on patent rights. However, many aspects of the legislation are uncertain and it is unclear how much of the legislation will be implemented in practice.
THE SUBRING OF GROUP COHOMOLOGY CONSTRUCTED BY PERMUTATION REPRESENTATIONS
David J. Green, Ian J. Leary, Björn Schuster
Journal: Proceedings of the Edinburgh Mathematical Society / Volume 45 / Issue 1 / February 2002
Each permutation representation of a finite group $G$ can be used to pull cohomology classes back from a symmetric group to $G$. We study the ring generated by all classes that arise in this fashion, describing its variety in terms of the subgroup structure of $G$.
We also investigate the effect of restricting to special types of permutation representations, such as $\mathrm{GL}_n(\mathbb{F}_p)$ acting on flags of subspaces.
AMS 2000 Mathematics subject classification: Primary 20J06
The Western Regional Air Partnership: Successor to the Grand Canyon Visibility Transport Commission
David Steele, John Leary, Bill Grantham
Journal: Environmental Practice / Volume 1 / Issue 1 / March 1999
Published online by Cambridge University Press: 13 July 2009, pp. 8-10
Scientific amnesia
Journal: Behavioral and Brain Sciences / Volume 8 / Issue 4 / December 1985