johvdvutqrpvcaaasalertsorg science online week science alert 319 5865 mirnas cancer webinar brought science join us february 20 2008 12 noon eastern standard time 9am pst 5pm gmt new webinar discussing mirnas cancer role mirnas human disease including cancer well established many questions remain however precisely mirnas exert effects whether make suitable biomarkers could applied therapeutically join three expert panelists discuss current research mirnas important tumorigenesis well techniques mirna discovery profiling time running register today wwwsciencemagorgwebinar produced aaasscience business office sponsored stratagene agilent technologies company current issue previous issue science express science products science journal week science volume 319 issue 5865 dated february 15 2008 available httpwwwsciencemagorgcontentvol319issue5865twisdtl copy week science section appended week science february 15 2008 319 5865 week science molecular rotary motor f1adenosine triphosphatase atpdriven rotary motor central subunit rotates inside static cylinder stator provides hydrophobic sleeve bottom rotor could act bearing force atp hydrolysis converted torque furuike et al p 955 truncated shaft leave rotor head top concave rotor orifice surprisingly head rotated correct direction average rotary speeds low motion sometimes irregular although fixed pivot rigid axle improve efficiency motor neither required achieve rotation credit furuike et al detecting less massive extrasolar planets astronomers discovered large number variety planets orbiting stars far solar system detections bodies masses much larger heaviest objects solar system largely methods detecting sensitive massive orbiting bodies gaudi et al p 927 see news story kerr report observation two planets masses less jupiter orbiting star mass half sun discovery made possible improved form gravitational lensing light distant stars bent planetary system way earth pinning wimp detectibility universe thought composed dark matter novel ways sought detect characterize one strong candidate dark matter socalled weakly interacting massive particles wimps interact weak force gravity interact electromagnetic radiation behnke et al p 933 show bubble chambers consist superheated liquids yield train bubbles heat produced particle passes tuned provide limits abundance wimps one challenge stabilizing chamber longterm measurements particle physics detections last milliseconds cross sections measured spindependent wimp coupling support recent claim darkmatter detection proton transfer charged ahead proton transfer hydrogen chloride ammonia prototypical acidbase reaction known proceed solution dense gaseous mixtures well however careful studies shown isolated hcl nh3 molecules pair vacuum form hydrogenbonded complex keeps shared proton closely associated chloride eustis et al p 936 see cover applied photoelectron spectroscopy theoretical simulations explore perturbations necessary induce full proton transfer found one driver binding excess electron resulting complex characterized neutral nh4 rydberg radical species polarized adjacent cl__ anion capturing co2 organic zeolite analogs porous metalorganic framework compounds useful gas sorption wide variety compounds could made especially different linkers metal atoms incorporated within material however expectation might two products one linkers would favored mixed system despite potential drawback banerjee et al p 939 see news story service show combinatorial microsynthetic approach uses znii coii centers imidazolate related linkers generates large number crystalline products tertrahedral frameworks zeolitic topologies 25 structures 10 heterolinkers 5 previously unobserved topologies three products show exceptional thermal stability 390c along high selectivity co2 versus co well high co2 uptake ambient conditions credit banerjee et al staying fold cells proteins continually subjected stresses could promote misfolding aggregation addition wide variety diseases caused misfolding aggregation key proteins balch et al p 916 review socalled proteostasis machinery cell uses combat problems authors highlight potential manipulation proteostasis machinery future efforts treat misfolding diseases getting handle hiv host factors hiv1 virus encodes handful proteins must exploit multiple host cell processes ensure completion lifecycle thus many potential host factors could influence hiv infection part remain unknown brass et al p 921 published online 10 january see 11 january news story cohen used genomewide small interfering rna functional screen identify large number hivdependency factors known many unknown several genes studied played roles viral entry integration biosynthesis assembly well later stages infection oceans threat order assign regional priorities globalscale marine resource management type extent human impacts worlds oceans must assessed quantitative global highresolution analyses cumulative impact 17 urgent land oceanbased threats marine ecosystems halpern et al p 948 show areas ocean untouched human activities third oceans heavily impacted spatial distribution impacts highly heterogeneous heavily affected ecosystems continental shelves rocky reefs coral reefs seagrass beds seamounts credit halpern et al cadherins road multicellularity early organisms made transition unicellularity multicellularity unknown although certain genes implicated important players process one group cadherin family genes function cell adhesion cellcell signaling examining genome unicellular choanoflagellate monosiga brevicollis abedin king p 946 show genome brevicollis contains 23 expressed cadherin genesas many several multicellular animals least two cadherins localized actinfilled microvilli protozoan feeding collar may participate recognition capture bacterial prey spider grasshopper predators control ecosystem dynamics schmitz p 952 see perspective naeem studied spiders grasshopper prey meadow ecosystem identified predator hunting mode prey response determinants ecosystem function actively hunting spider species grasshoppers largely ignored reduced plant species diversity enhanced aboveground net primary production litter quality nitrogen mineralization rates whereas sitandwait ambush spider species grasshoppers avoided opposite effects top predators marine terrestrial ecosystems among fastest disappearing elements biodiversity understanding role local ecosystem functioning may help predict effects loss filtering bad less bad maternally inherited mitochondrial dna mtdna mutations implicated variety human diseases including cardiomyopathy neurodegenerative disorders assumed mtdna mutations randomly segregated genetic drift within female germline fan et al p 958 see perspective shoubridge wai created sophisticated mouse model allowed monitor fates phenotypic effects mtdnas containing mutations varying severity surprisingly pathogenic mtdna mutation quickly eliminated female germline whereas moderately deleterious mtdna mutation continued transmitted multiple generations thus female germline filters deleterious mtdna mutations prior conception thereby minimizing impact population fitness practice practice practice artur rubinsteins response asked way carnegie hall manhattan may fact apply forms study well karpicke roediger p 966 examined undergraduates tasked learning meanings 40 words swahili repeated testing already learned words enhanced longterm recall assessed 1 week later whereas repeated studying beneficial effects testing required students retrieve englishswahili word associations suggests encoding although critical formation memory may sufficient retention consolidation mapping surface phonons phonons vibrational modes crystals usually measured spectroscopically bulk samples gawronski et al p 930 show phonon modes mapped closepacked 111 surfaces gold copper cryogenic conditions 5 kelvin scanning tunneling microscope stm inelastic tunneling electronic spectra obtained measuring second derivative tunneling current respect voltage authors observed expected shift phonon peak 14 millielectron volts two metals changes phonon maps observed atomic resolution resulted local variations probability exciting phonon mode retracing mantle helium helium isotopes provide tracer mantle processes abundant 4he produced earth radioactive decay whereas 3he derives material trapped earths formation addition helium degassing throughout earths history thus thought volcanoes low 4he3he ratios might tapping less degassed primitive layers earths mantle however recent data showing volcanoes also tap regions mantle containing recycled ocean crust thus likely degassed complicated simple picture albarède p 943 published online 17 january proposes solution helium diffused certain layers parts mantle high melting points even well mixed distribution volcanic emissions explained different degrees tapping pieces full metal abscess tissue abscesses form bacteria meet cells immune system notably neutrophils corbin et al p 962 see perspective novick find abundant neutrophil protein calprotectin protects host bacterial growth chelating metal ions used bacteria nutrients mice bacterial infection calprotectin localized tissue abscesses chelated manganese zinc ions infected mice lacking calprotectin elevated metal levels increased bacterial growth tissue abscesses unsubscribe edit subscriptions service httpwwwsciencemagorgcgialertsmain written requests unsubscribe may sent customer service 1454 page mill road palo alto ca 94304 usa magazine news signaling careers multimedia collections help site map rss subscribe feedback privacy legal us advertise us contact us 2008 american association advancement science rights reservedaaas partner hinari agora patientinform crossref counter mirnas cancer webinar brought science join us february 20 2008 12 noon eastern standard time 9am pst 5pm gmt new webinar discussing mirnas cancer role mirnas human disease including cancer well established many questions remain however precisely mirnas exert effects whether make suitable biomarkers could applied therapeutically join three expert panelists discuss current research mirnas important tumorigenesis well techniques mirna discovery profiling time running register today wwwsciencemagorgwebinar produced aaasscience business office sponsored stratagene agilent technologies company tue 05 aug 2008 173511 0800 science citetrack week science