johvdvutqrpvcaaasalertsorg science online week science alert 319 5868 sponsored qiagen qiasymphony sp pure performance cuttingedge technology optimized protocols unrivaled application range innovative qiasymphony sp qiagen sets new milestone automated sample technologies standardized processing enables reproducible purification highly pure dna rna proteins 96 samples per run giving highperformance results routine applications qiasymphony sp intended used combination qiasymphony kits applications described respective qiasymphony kit handbooks trademarks qiagen qiasymphony qiagen group link wwwqiagencomgotoqiasymphonystoc current issue previous issue science express science products science journal week science volume 319 issue 5868 dated march 7 2008 available httpwwwsciencemagorgcontentvol319issue5868twisdtl copy week science section appended week science march 7 2008 319 5868 week science toward designer antibiotics past years alarming increase number methicillinresistant staphylococcus aureus mrsa infections occurring hospitals community liu et al p 1391 published online 14 february suggest antibiotic approach targets pigment staphyloxanthin besides giving aureus golden color provides resistance killing host immune system early steps staphyloxanthin biosynthesis resemble cholesterol biosynthesis enzyme involved pigment biosynthesis crtm dehydrosqualene synthase structurally similar human squalene synthase sqs inhibitors sqs screened activity crtm structures crtm bound three compounds inhibited pigment formation vitro examined one inhibitors initial human clinical trials cholesterollowering agent increased susceptibility aureaus killing innate immune system credit liu et al reconciling sealevel changes estimates global sea level cretaceous period vary widely sometimes difficult reconcile geological record widespread continental flooding occurred order remove contradictions müller et al p 1357 incorporate marine geophysical data reconstructions ocean basin volumes show global sea level 175 235 meters higher cretaceous climate much warmer today moreover using mantle convection model incorporate effect dynamic topography east coast north america associated movement subducted fallaron plate different sealevel reconstructions reconciled seemed mutually exclusive rings around rhea rhea one saturns largest moons lies outside main rings planet heavily cratered described jones et al p 1380 see news story kerr cassini recently flew rhea able detect depletion ionized particles electrons saturns magnetotail downstream rhea several radii moon analysis data geometry depletion imply rhea may ring system formed dust lofted moon impacts caused observed depletions model citizens much made prosocial force altruistic punishment human societiesthe willingness individuals incur personal costs order coerce others behaving cooperative fashion herrmann et al p 1362 see cover perspective gintis describe large data set collected university students across range societies frequency extent behaviors antisocial naturewhere individuals punished would react punishing cooperatorswas correlated previous survey data measuring social norms civic cooperation rule law societies crosssocietal variation antisocial punishment associated crosssocietal variation cooperative behavior prevalent societies weaker social norms grand canyon dates incision history grand canyon unsettled issue part common dating methods rely analysis basalt flows travertine provide information samples older 1 million years order overcome limitation polyak et al p 1377 see perspective atkinson leeder take advantage technical advances uraniumlead dating methods date cave mammillaries type speleothem forms caves near depth water table structures common throughout canyon authors could construct history incision extends back 17 million years much length canyon changing stiffness solvents sea cucumber rapidly reversibly alter stiffness inner dermis capadona et al p 1370 created material mimics properties combining rubber copolymer cellulose nanofibers taken tunicates addition hydrogenbonding solvent causes fibers segregate process reversed upon removal solvent causes reaggregation fibers form percolating network interfering cellulose network way stiffness composite altered factor 40 credit capadona et al seeing optical event horizon event horizon gravitational black hole represents point returnparticles inside boundary including photons escape however direct observation event horizon possibility verifying proposed theoretical properties appear remote looking labbased analogies may describe underlying physics philbin et al p1367 see news story cho report found connection light propagation optical fibers black hole physics report observation optical event horizon probe expected properties frequency shifting probe light authors also propose scenario observing hawking radiation getting balance wrong cancer development lies balance tumorsuppressing activities tumorpromoting activities halazonetis et al p 1352 review accumulating evidence oncogenes force cells rapid cycles cell division lead cancer cause errors dna replication accumulation damaged dna cells detect problems dna replication signal p53 tumor suppressor protein delay cell cycle progression mutations p53 common cancer cells presumably bypass barrier tumorigenesis toward designer enzymes creation designer enzymes new activities remains challenge jiang et al p 1387 take step direction computationally designing retroaldolase multistep reaction catalyzes breaking carboncarbon bond nonnatural substrate seventytwo designs representing four different catalytic motifs 10 different scaffolds examined activesite designs used charged sidechain networks mediate proton transfer less successful simpler designs used water molecule close agreement two crystal structures corresponding design models validated design procedure however catalytic proficiency designed proteins remains far natural enzymes toward designer gas vaccine proteins antigenically variable cellsurface virulence factors group streptococcus gas organism important cause human illness notably provokes autoimmune disease rheumatic fever mcnamara et al p 1405 examined fragment m1 binds host fibrinogen promotes inflammation m1 protein consists helical coiled coils bearing distinctive structural features impart irregularity instability coiled coil features mimic muscle myosin tropomyosin may explain postinfection autoimmune responses mice immunized mutant stabilized protein exhibited reduced harmful inflammation without compromising protective immune responses credit mcnamara et al finescale analysis human variation two reports examine patterns human recombination underlie significant variation exists among humans coop et al p 1395 published online 31 january genotyped individuals hutterite population identified fine scale recombination events generations kong et al p 1398 published online 31 january examined parents icelandic population identify gene associated recombination frequency together studies point genomic region affecting variation recombination levels among individuals directly modulating glucose homeostasis concentration glucose bloodstream regulated glucose along hormones insulin glucagon glucagon stimulates gluconeogenesis part regulating phosphorylation transcriptional coactivator known cyclic adenosine monophosphate response elementbinding protein 2 crtc2 dentin et al p 1402 see perspective birnbaum found high concentrations circulating glucose also regulate crtc2 stimulation hexosamine biosynthetic pathway consequent olinked glycosylation serine residue crtc2 modified phosphorylation core aerosol issues formation new aerosol particles begins formation nanometerscale condensation nuclei crucial step formation aerosols affects atmospheric processes cloud formation difficult understand detail mainly tools needed generate relevant particles nanometer sizerange unavailable winkler et al p 1374 made tungsten oxide nanoparticles nearly small molecules use particles different charge states investigate activation growth npropanol aerosols particles well positive negative ions observations role size charge nucleation allow accurate description cluster activation illuminate role organic compounds new atmospheric particle formation plants going topless plant hormone auxin key regulator proper plant development failure properly respond auxin leads inability develop root vasculature arabidopsis embryogenesis szemenyei et al p 1384 published online 7 february show topless integral cofactor required proper auxin response auxiaa pathway data provide insight mechanism auxinmediated transcription directs plant development unsubscribe edit subscriptions service httpwwwsciencemagorgcgialertsmain written requests unsubscribe may sent customer service 1454 page mill road palo alto ca 94304 usa magazine news signaling careers multimedia collections help site map rss 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