johvdvutqrpvcaaasalertsorg science online editors choice alert 319 5864 mirnas cancer webinar brought science join us february 20 2008 12 noon eastern standard time 9am pst 5pm gmt new webinar discussing mirnas cancer role mirnas human disease including cancer well established many questions remain however precisely mirnas exert effects whether make suitable biomarkers could applied therapeutically join three expert panelists discuss current research mirnas important tumorigenesis well techniques mirna discovery profiling time running register today wwwsciencemagorgwebinar produced aaasscience business office sponsored stratagene agilent technologies company current issue previous issue science express science products science journal editors choice highlights recent literature science volume 319 issue 5864 cities dated february 8 2008 available httpwwwsciencemagorgcontentvol319issue5864twildtl copy editors choice highlights recent literature section appended editors choice highlights recent literature february 8 2008 319 5864 editors choice highlights recent literature geology ups downs stress brooks hanson hawaiian islands formed sequentially pacific ocean crust moved locus melting mantle island grows huge weight cooled magma pile extending many kilometers ocean floor bends ocean crust downward two related large mw 60 67 earthquakes struck island hawaii 15 october 2006 helped reveal important aspects process earthquakes occurred mantle one particularly deep 39 km surface implied local extension shallower depth 19 km suggested lateral compression finiteelement modeling mcgovern shows different mechanisms reflect modification broad bending process different strengths lower crust mantle producing compression depths shallower 32 km extension strain focused near depth deeper quake addition compression depth 19 km would tend restrict ascent magmas consistent notion crust underplated cooled magmas depth bh geophys res lett 34 l23305 2007 plant science pared essentials pamela j hines rna world alive welldeeply embedded plants plant viruses traveling messenger rnas genesilencing rnas various guises rna plants infectious rnas structural motifssequences form hairpins loops bulgesare necessary rna replication rna trafficking cells using genomewide mutational analysis potato spindle tuber viroid pstvd replicates host cells nucleus zhong et al investigated two processes share terms structural motifs potatoes produced plants infected viroid smaller lumpier usual viroids move leaf cells phloem distant parts pstvd rna adopts rodshaped structure loops essential fully successful replication trafficking loops toward one end rod middle critical replication damage loop 11 produced viroids able travel well apt replicate finally one loop native state actually seemed repress replication comparisons types viroid rnas hint conservation structurefunction relationships loops pjh plant cell 20 101105tpc107056606 2008 applied physics light amid disorder david voss semiconductors concept energy gap separates conducting electrons localized valence states fundamental understanding materials optical electronic properties researchers discovered 1980s photons behave similar way optical materials fabricated right periodic structures exhibit energy frequency regions light passes energy zones transmission light blocked semiconductor band gaps lead wide range useful technological properties photonic band gaps optical materials researchers assumed order produce photonic band gaps highquality crystalline materials required edagawa et al present computational results showing amorphous diamond without lattice periodicity also exhibit strong photonic band gaps results challenge traditional view photonic band gaps strictly consequence bragg reflection interference electromagnetic waves scattered various planes formed periodic atomic lattice thus range photonic band gap systems could potentially synthesized materials polymers proteins colloids lend naturally amorphous structures dv phys rev lett 100 13901 2008 physics profiles charge ian osborne availability highpower lasers emitting intense pulses femtosecond picosecond time scales enables study highfield processes photodissociation photoexcition atoms molecules laboratory processes relevant across range disciplines study photoinduced chemical reactions atmosphere fundamental probing electronic excitations atoms intense laser pulse hits cloud atoms molecules intensity profile laser pulse produce specific distribution ions exciting cloud xe atoms intense laser pulses strohaber uiterwaal implement timeofflight technique samples pulse focal region micrometer resolution allowing distribution ions mapped three dimensions flip side profile ion distributions used intensity sensor aid characterization optimization intense laser pulses iso phys rev lett 100 23002 2008 genomics highsalt lifestyle barbara r jasny bonneau et al describe progress effort link systemslevel analysis events molecular organismal levels using experiments computation pooled transcriptome proteinprotein interaction structural evolutionrelated data generate dynamic model halophilic organism halobacterium salinarum model trained data sets included 200 microarray experiments measuring responses genetic perturbations environmental factors oxygen sunlight transition metals ultraviolet radiation desiccation rehydration model known egrin environment gene regulatory influence network represents transcriptional regulation 1929 2400 genes h salinarum used predict transcriptional changes environmental genetic perturbations combinations thereof held training data sets example gene nhac3 encodes na extrusion pump allows organism grow highsalt conditions analyses map proteindna interactions generated chipchip data could dissect five possible transcriptional regulators governed expression gene yet one predicted egrin strongest effect confirmed laboratory experiments bj cell 131 1354 2007 environment debt nations caroline ash tracking worldwide depletion ecosystem resources complex international problem srinivasan et al used simplified accounting framework link populations experience ecological damage cause largest blatant imbalance debt highincome countries owe lowincome countries climate change per capita basis people highincome countries responsible almost six times greenhouse gas emissions lowincome counterparts included tally instance luxury debt accrued highincome consumers farmed shrimp demand encourages destruction coastal mangrove trees clear way shrimp ponds resulting loss storm protection increasing risk adjacent cities sea levels rise coral reefs collapse see also grimm et al review p 756 similarly middleand highincome countries consume worlds fish nevertheless several fooddeficient african countries charge modest access fees mining rich offshore fisheries despite difficulties measurement need simplify analysis raises provocative questions division responsibilities environmental harm ca proc natl acad sci usa 105 101073pnas0709562104 2008 science signaling hearing essentials glutamate transporters elizabeth adler although three vesicular glutamate transporters vgluts identified two found identified glutamatergic neurons contrast vglut3 expressed several populations neurons release classical neurotransmitters including inhibitory gabaergic interneurons hippocampus cortex seal et al found mice lacking vglut3 profoundly deaf failed show startle response loud noises exhibit auditory evoked potentials electrophysiological analysis revealed defect signaling inner hair cells ihcs cochlea auditory nerve morphological analysis showed abnormalities ihc synapses immunofluorescence revealed vglut3 present synaptic regions ihcs wildtype mice whereas conductances ihcs mice lacking vglut3 resembled wildtype mice electrophysiological analysis indicated neurons failed release glutamate authors conclude vglut3 essential hearing plays important role regulation cortical excitability ema neuron 57 263 2008 unsubscribe edit subscriptions service httpwwwsciencemagorgcgialertsmain written requests unsubscribe may sent customer service 1454 page mill road palo alto ca 94304 usa magazine news signaling careers multimedia collections help site map rss subscribe feedback privacy legal us advertise us contact us 2008 american association advancement science rights reservedaaas partner hinari agora patientinform crossref counter mirnas cancer webinar brought science join us february 20 2008 12 noon eastern standard time 9am pst 5pm gmt new webinar discussing mirnas cancer role mirnas human disease including cancer well established many questions remain however precisely mirnas exert effects whether make suitable biomarkers could applied therapeutically join three expert panelists discuss current research mirnas important tumorigenesis well techniques mirna discovery profiling time running register today wwwsciencemagorgwebinar produced aaasscience business office sponsored stratagene agilent technologies company tue 05 aug 2008 121518 0800 science citetrack editors choice highlights recent literature