25,5 NA 0.03 ♀ 1, IV beagle 27 20 NA 0.03 ♂ dogs, 28 days 20 NA 0.03 ♀ 1 111.7 NA 0.1 5, IV ♂ 141.1 NA 0.2 ♀ 27 102.2 NA 0.1 ♂ 121.9 NA 0.2 ♀ 1 352.3 NA 0.4 15, IV ♂ 351.7 NA 0.4 ♀ 27 335.6 NA 0.4 ♂ 335.9 NA 0.4 ♀ 1 172.7 NA 0.2 15, oral ♂ gavage 167.6 NA 0.2 ♀ 27 163 NA 0.2 ♂ 165 NA 0.2 ♀ 1 NA 65.5 1048 NA CPI-CL-001, 200 mg, IV human 1 NA 112.5 900 NA 400 mg, IV healthy 1 NA 198.2 NA 792.8 volunteers, IV 800 mg, IV (60 min infusion) or 1 NA 69.9 838.8^ NA 200 mg, PO PO 1 NA 110.9 665.4^ NA 400 mg, PO n=12/group 1 NA 218.8 656.4^ NA 800 mg, PO 1 NA 196 784 NA CPI-CL-011, 800 mg, IV human healthy 1 NA 196 588^ NA 800 mg, volunteers, IV (5-7 min infusion), or PO n=12/group 1 NA 22.3& 713.6 NA CPI-CL-004, 100 mg, IV hospitalized 1 NA 32.6& 521.6 NA adult febrile 200 mg, IV patients, IV (30 min 1 NA 70.6& 564.8 NA 400 mg, IV infusion)
beagle dogs, 28 days 1, IV ♀ 25,5 NA 0.03 27 ♂ ♀ 20 20 NA NA 0.03 0.03 5, IV 1 ♂ ♀ 111.7 141.1 NA NA 0.1 0.2 27 ♂ ♀ 102.2 121.9 NA NA 0.1 0.2 15, IV 1 ♂ ♀ 352.3 351.7 NA NA 0.4 0.4 27 ♂ ♀ 335.6 335.9 NA NA 0.4 0.4 15, oral gavage 1 ♂ ♀ 172.7 167.6 NA NA 0.2 0.2 27 ♂ ♀ 163 165 NA NA 0.2 0.2 CPI-CL-001, human healthy volunteers, IV (60 min infusion) or PO n=12/group 200 mg, IV 400 mg, IV 800 mg, IV 1 1 1 NA NA NA 65.5 112.5 198.2 1048 900 792.8 NA NA NA 200 mg, PO 400 mg, PO 800 mg, PO 1 1 1 NA NA NA 69.9 110.9 218.8 838.8^ 665.4^ 656.4^ NA NA NA CPI-CL-011, human healthy volunteers, IV (5-7 min infusion), or PO n=12/group 800 mg, IV 1 NA 196 784 NA 800 mg, 1 NA 196 588^ NA CPI-CL-004, hospitalized adult febrile patients, IV (30 min infusion) 100 mg, IV 1 NA 22.3& 713.6 NA 200 mg, IV 1 NA 32.6& 521.6 NA 400 mg, IV 1 NA 70.6& 564.8 NA
auspar-ibuprofen-130102.docx