Inhalation anesthetics Isoflurane 1-3% Whenever general Survival surgery requires concurrent inhalant to anesthesia is preemptive analgesia. Must use precision effect (up to required vaporizer 5% for induction). Injectable anesthetics 75-100 As needed Recommended: Ketamine- mg/kg Xylazine mg/kg IP or IM (in same syringe) 75-100 As needed Ketamine- May not produce surgical-plane anesthesia for Dexmedetomidine mg/kg + 0.15 major procedures. If re-dosing, use ketamine mg/kg IP or alone. IM May be partially reversed with Atipamezole (in same syringe) Sodium 40-50 mg/kg Recommended for procedures. Pentobarbital IP If used for survival surgery, should use (Nembutal) supplemental analgesia. Reversal agents Atipamezole 0.1-1.0 Any time More specific for medetomidine than for mg/kg IM or medetomidine or xylazine (as a general rule, Atipamezole is IP xylazine had been dosed at the same volume as Medetomidine, used though they are manufactured at different concentrations.) Hamster Drug Dose and Frequency Notes Route Inhalation anesthetics Recommended: 1-3% Whenever general Survival surgery requires concurrent preemptive Isoflurane or inhalant to anesthesia is analgesia. Must use precision vaporizer Sevoflurane effect (up to required 5% for induction). Up to 8% for Sevoflurane Ketamine combinations
Inhalation anesthetics Isoflurane 1-3% inhalant to effect (up to 5% for induction). Whenever general anesthesia is required Survival surgery requires concurrent preemptive analgesia. Must use precision vaporizer Injectable anesthetics Recommended: Ketamine- Xylazine 75-100 mg/kg mg/kg IP or IM (in same syringe) As needed Ketamine- Dexmedetomidine 75-100 mg/kg + 0.15 mg/kg IP or IM (in same syringe) As needed May not produce surgical-plane anesthesia for major procedures. If re-dosing, use ketamine alone. May be partially reversed with Atipamezole Sodium Pentobarbital (Nembutal) 40-50 mg/kg IP Recommended for procedures. If used for survival surgery, should use supplemental analgesia. Reversal agents Atipamezole 0.1-1.0 mg/kg IM or IP Any time medetomidine or xylazine had been used More specific for medetomidine than for xylazine (as a general rule, Atipamezole is dosed at the same volume as Medetomidine, though they are manufactured at different concentrations.) Hamster Drug Dose and Route Frequency Notes Inhalation anesthetics Recommended: Isoflurane or Sevoflurane 1-3% inhalant to effect (up to 5% for induction). Up to 8% for Sevoflurane Whenever general anesthesia is required Survival surgery requires concurrent preemptive analgesia. Must use precision vaporizer Ketamine combinations
Anesthesia_in_Laboratory_Animals.docx