for the period respiratory disease. before1975. The all-cause linear model would imply a Used job 14% increase in descriptions to mortality for mine estimate for workers exposed each job the occupationally to 100 duration and fibre/mL-year or about the number of 3.2% for a general spent by population exposed for workers in 50 years to an ambient different concentration of 0.1 operation fibre/mL not – locations; the insignificant impact. cumulative exposure was then calculated Rohs et al RMA ID: Low-Level 280 mine Vermiculite Cumulative Fibre Duration of Radiographic study Asbestos (2008) 067995 Fiber-Induced workers of the mine/mill exposure: concentration exposure: reporting vermiculite exposure Radiographic original 513 N=280 method used: N=280 based - induced interstitial producing Changes cohort (94.3% M=2.48 Membrane on hire date change and pleural interstitial Caused by men) (SD=4.19; filters method changes in a cohort changes seen Libby since 1972. of vermiculite at 11.37 80=pleural Hired on or Vermiculite. A workers changes Cumulative before 1973 25-Year fibre/mL-year (68=localised fibre exposure Significant increase n =186 Follow-up pleural plaques was calculated seen in the follow-up in Study Hired after 12=diffuse using the pleural changes: 2.0% Cumulative 1973 pleural TWA by in the 1980 study to exposure - thickening, the number of 28.7% in 2005. 94 n= (Chest Interstitial 28.7%) at the Interstitial changes: radiographic changes TWA summed 0.2% in 1980 to 2.9% changes only) 8=Interstitial (n=8): M= overall years in 2005 changes 11.86 according to (irregular department.
for the period before1975. Used job descriptions to estimate for each job the duration and the number of spent by workers in different operation locations; the cumulative exposure was then calculated respiratory disease. The all-cause linear model would imply a 14% increase in mortality for mine workers exposed occupationally to 100 fibre/mL-year or about 3.2% for a general population exposed for 50 years to an ambient concentration of 0.1 fibre/mL – not insignificant impact. Rohs et al (2008) RMA ID: 067995 Low-Level Fiber-Induced Radiographic Changes Caused by Libby Vermiculite. A 25-Year Follow-up Study (Chest radiographic changes only) 280 mine workers of the original 513 cohort (94.3% men) 80=pleural changes (68=localised pleural plaques 12=diffuse pleural thickening, 28.7%) 8=Interstitial changes (irregular Vermiculite mine/mill Cumulative exposure: N=280 M=2.48 (SD=4.19; fibre/mL-year Cumulative exposure - Interstitial changes (n=8): M= 11.86 Fibre concentration method used: Membrane filters method since 1972. Cumulative fibre exposure was calculated using the TWA by the number of at the TWA summed overall years according to department. Duration of exposure: N=280 based on hire date Hired on or before 1973 n =186 Hired after 1973 n= 94 Radiographic study reporting vermiculite - induced interstitial change and pleural changes in a cohort of vermiculite workers Significant increase seen in the follow-up in pleural changes: 2.0% in the 1980 study to 28.7% in 2005. Interstitial changes: 0.2% in 1980 to 2.9% in 2005 Asbestos exposure producing interstitial changes seen at 11.37
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