Abdominal pain 8 0 3 0 (11) 0 (2) 0 Constipation 11 1 21 1 (15) (1) 0 (14) (1) 0 Diarrhoea 27 3 35 2 (36) (4) 1 (24) (1) 1 (1) (1) Nausea 14 0 27 0 (19) 0 (18) 0 Vomiting 0 3 12 17 (2) (16) 1 (12) 0 (1) General disorders and administration site conditions Asthenia 14 4 23 3 (19) (5) 0 (16) (2) 0 Fatigue 15 3 17 3 (20) (4) 0 (12) (2) 0 Pyrexia 12 0 28 0 (16) 0 (19) 0 Infections and infestations Herpes zoster 7 1 16 2 (9) (1) 0 (11) (1) 0 Metabolism and nutrition disorders Decreased 7 0 14 0 appetite (9) 0 (10) 0 Musculoskeletal and connective tissue disorders Pain in extremity 8 2 8 1 (11) (3) 0 (5) (1) 0 Nervous system disorders Headache 8 0 5 0 (11) 0 (3) 0 Neuralgia 17 7 35 5 (23) (9) 0 (24) (3) 0 Peripheral sensory 36 51 5 neuropathy (49) 10 1 (35) (3) 0 (14) (1) Psychiatric disorders Insomnia 8 0 18 0 (11) 0 (12) 0 Respiratory, thoracic and mediastinal disorders Dyspnoea 9 2 11 2 (12) (3) 0 (7) (1) 0 Note: Percentages in 'Total' column for each group calculated with the number of subjects in each group as denominator.
Abdominal pain 8 (11) 0 0 3 (2) 0 0 Constipation 11 (15) 1 (1) 0 21 (14) 1 (1) 0 Diarrhoea 27 (36) 3 (4) 1 (1) 35 (24) 2 (1) 1 (1) Nausea Vomiting 14 (19) 12 (16) 0 0 0 1 (1) 27 (18) 17 (12) 0 3 (2) 0 0 General disorders and administration site conditions Asthenia 14 (19) 4 (5) 0 23 (16) 3 (2) 0 Fatigue 15 (20) 3 (4) 0 17 (12) 3 (2) 0 Pyrexia 12 (16) 0 0 28 (19) 0 0 Infections and infestations Herpes zoster 7 (9) 1 (1) 0 16 (11) 2 (1) 0 Metabolism and nutrition disorders Decreased appetite 7 (9) 0 0 14 (10) 0 0 Musculoskeletal and connective tissue disorders Pain in extremity 8 (11) 2 (3) 0 8 (5) 1 (1) 0 Nervous system disorders Headache 8 (11) 0 0 5 (3) 0 0 Neuralgia Peripheral sensory neuropathy 17 (23) 36 (49) 7 (9) 10 (14) 0 1 (1) 35 (24) 51 (35) 5 (3) 5 (3) 0 0 Psychiatric disorders Insomnia 8 (11) 0 0 18 (12) 0 0 Respiratory, thoracic and mediastinal disorders Dyspnoea 9 (12) 2 (3) 0 11 (7) 2 (1) 0 Note: Percentages in 'Total' column for each group calculated with the number of subjects in each group as denominator.
auspar-bortezomib-160226-pi.docx