epilepsy controls Absolute right Intercept 0.48 (0.53-0.68) <0.0005 thalamic volume Group [0 refractory, 1 healthy control] -0.09 (-0.5-0.12) 0.472 Refractory Age [years] 0.0002 (-0.001-0.006) 0.947 epilepsy Total brain volume 0.011 (0.003-0.018) 0.038 controls versus healthy controls Legend: CI: Confidence interval. ESES: Electrical status epilepticus in sleep. CORRECTION FOR AGE AND GENDER Linear regressions comparing the absolute thalamic and brain volumes between the groups correcting for age and gender. Element in the linear regression model Coefficient with 95%CI p-value LEFT THALAMUS Left thalamus Intercept 6.26 (5.53 - 6.99) <0.0005 ESES patients Group [0 ESES patients, 1 healthy controls] 0.62 (0.20 - 1.04) 0.005 versus healthy Age [years] 0.07 (0.008 - 0.14 0.029 controls Gender [0=female, 1=male] 0.50 (0.13 - 0.87) 0.009 Left thalamus Intercept 5.77 (4.89 - 6.64) <0.0005 ESES patients Group [0 ESES patients, 1 refractory epilepsy] -0.07 (-0.50 - 0.37) 0.762 versus refractory Age [years] 0.13 (0.06 - 0.21) 0.001 epilepsy controls Gender [0=female, 1=male] 0.42 (-0.02 - 0.85) 0.060 5.97 (5.40 - 6.54) <0.0005 Left thalamus Intercept Refractory Group [0 refractory, 1 healthy control] 0.66 (0.32 - 0.9987) <0.0005 epilepsy controls 0.10 (0.05 - 0.16) Age [years] versus healthy <0.0005 controls Gender [0=female, 1=male] 0.40 (0.08 - 0.72) 0.016 RIGHT THALAMUS
epilepsy controls Absolute right thalamic volume Refractory epilepsy controls versus healthy controls Intercept Group [0 refractory, 1 healthy control] Age [years] Total brain volume 0.48 (0.53-0.68) -0.09 (-0.5-0.12) 0.0002 (-0.001-0.006) 0.011 (0.003-0.018) <0.0005 0.472 0.947 0.038 Legend: CI: Confidence interval. ESES: Electrical status epilepticus in sleep. CORRECTION FOR AGE AND GENDER Linear regressions comparing the absolute thalamic and brain volumes between the groups correcting for age and gender. Element in the linear regression model Coefficient with 95%CI p-value LEFT THALAMUS Left thalamus ESES patients versus healthy controls Intercept Group [0 ESES patients, 1 healthy controls] Age [years] Gender [0=female, 1=male] 6.26 (5.53 - 6.99) 0.62 (0.20 - 1.04) 0.07 (0.008 - 0.14 0.50 (0.13 - 0.87) <0.0005 0.005 0.029 0.009 Left thalamus ESES patients versus refractory epilepsy controls Intercept Group [0 ESES patients, 1 refractory epilepsy] Age [years] Gender [0=female, 1=male] 5.77 (4.89 - 6.64) -0.07 (-0.50 - 0.37) 0.13 (0.06 - 0.21) 0.42 (-0.02 - 0.85) <0.0005 0.762 0.001 0.060 Left thalamus Refractory epilepsy controls versus healthy controls Intercept Group [0 refractory, 1 healthy control] Age [years] Gender [0=female, 1=male] 5.97 (5.40 - 6.54) 0.66 (0.32 - 0.9987) 0.10 (0.05 - 0.16) 0.40 (0.08 - 0.72) <0.0005 <0.0005 <0.0005 0.016 RIGHT THALAMUS
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