= 50 (data from UKWIR 2014). 4 Propanolol Blood pressure Low removal, lowering CIP1 PNEC applied = 0.1 µg/L (astrazeneca.com and et al. atenolol (2011). PNEC applied = 148 µg/L (astrazeneca.com and et al. (2011). 5 amoxicillin Penicillin-like (β expected to be lactam) antibiotic unstable - considered but NOT forward 6 erythromycin, Low removal “Macrolide”antibiotics norerythromycin noted in CIP1 PNEC applied = 0.2 µg/L (JRC 2016). azithromycin - low Low usage high usage toxicity PNEC applied = 0.09 µg/L (JRC 2016). clarithromycin - higher usage Higher usage moderate toxicity PNEC applied = 0.13 µg/L (JRC 2016). 7 ciprofloxacin Antibiotic High usage
= 50 (data from UKWIR 2014). 4 Propanolol atenolol Blood pressure lowering Low removal, CIP1 PNEC applied = 0.1 µg/L (astrazeneca.com and et al. (2011). PNEC applied = 148 µg/L (astrazeneca.com and et al. (2011). 5 amoxicillin Penicillin-like (β lactam) antibiotic expected to be unstable - considered but NOT forward 6 erythromycin, norerythromycin azithromycin - low usage clarithromycin - higher usage “Macrolide”antibiotics Low removal noted in CIP1 PNEC applied = 0.2 µg/L (JRC 2016). Low usage high toxicity PNEC applied = 0.09 µg/L (JRC 2016). Higher usage moderate toxicity PNEC applied = 0.13 µg/L (JRC 2016). 7 ciprofloxacin Antibiotic High usage
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