approaches such as those described by the Adverse Outcome Pathway concept 3 …Using (Ankley et al. 2010) may help establish robust linkages between mechanistic endpoints and adverse effects. IPCS MoA Framework This framework considers the following steps in the evaluation of potential MoAs. Problem formulation / Hypothesised MoA statement 1a Summary of data for use in MoA analysis 1b Listing of key events identified for a specific MoA Bradford Hill considerations for WoE of available data/information for MoA analysis 3 in experimental species Dose response relationships and temporal association Consistency and specificity biological plausibility – Qualitative and quantitative human concordance
…Using approaches such as those described by the Adverse Outcome Pathway concept (Ankley et al. 2010) may help establish robust linkages between mechanistic endpoints and adverse effects. 3 IPCS MoA Framework This framework considers the following steps in the evaluation of potential MoAs. Problem formulation / Hypothesised MoA statement Summary of data for use in MoA analysis Listing of key events identified for a specific MoA Bradford Hill considerations for WoE of available data/information for MoA analysis in experimental species Dose response relationships and temporal association Consistency and specificity – biological plausibility Qualitative and quantitative human concordance 1a 1b 3
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