sufficient to induce asbestos-related disease. Anonymous RMA ID: Asbestos, Not reported Not reported For clinical Not reported Report.Author’s (1997) 026517 Asbestosis, and purposes, the conclusion: asbestosis Cancer: the following generally associated high Helsinki Criteria are exposure levels with for Diagnosis recommended to radiological signs of and Attribution identify persons parenchymal fibrosis. with a high Mild fibrosis may occur at probability of lower exposure levels, exposure to and detectable asbestos dust at parenchymal fibrosis may work: > 0.1 million not been seen on X-rays. amphibole fibres HRCT can confirm (>5 per gram radiological findings of μm) of dry lung tissue asbestosis and show or over I million early changes not seen amphibole fibres on chest X-rays. (>1 ) per gram Cumulative exposure, on μm of dry lung tissue; a probability basis, should or over 1000 be considered the main asbestos bodies criterion for the attribution per gram of dry of a substantial tissue (100 contribution by asbestos asbestos bodies to lung cancer risk. RR is per gram of wet roughly doubled for tissue) or over 1 exposed to asbestos body per asbestos fibres at a mL of cumulative exposure of bronchoalveolar 25 fibre-years or with an lavage fluid, as equivalent occupational measured by light history, at which level microscopy asbestosis may or may not be present or
sufficient to induce asbestos-related disease. Anonymous (1997) RMA ID: 026517 Asbestos, Asbestosis, and Cancer: the Helsinki Criteria for Diagnosis and Attribution Not reported Not reported For clinical purposes, the following are recommended to identify persons with a high probability of exposure to asbestos dust at work: > 0.1 million amphibole fibres (>5 μm) per gram of dry lung tissue or over I million amphibole fibres (>1 μm ) per gram of dry lung tissue; or over 1000 asbestos bodies per gram of dry tissue (100 asbestos bodies per gram of wet tissue) or over 1 asbestos body per mL of bronchoalveolar lavage fluid, as measured by light microscopy Not reported Report.Author’s conclusion: asbestosis generally associated high exposure levels with radiological signs of parenchymal fibrosis. Mild fibrosis may occur at lower exposure levels, and detectable parenchymal fibrosis may not been seen on X-rays. HRCT can confirm radiological findings of asbestosis and show early changes not seen on chest X-rays. Cumulative exposure, on a probability basis, should be considered the main criterion for the attribution of a substantial contribution by asbestos to lung cancer risk. RR is roughly doubled for exposed to asbestos fibres at a cumulative exposure of 25 fibre-years or with an equivalent occupational history, at which level asbestosis may or may not be present or
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