Costanzo/2005 Single-arm, 20 75% ischemic 31 ± 15% IV: 39% Peripheral edema: Max rate 500 cc/hr, BUN 90 days NYHA class IV: open label (range 10% 80% reduced to 200 cc/hr Baseline: 53 ± 18 (26) 30 days: 1 (5%) to 65%) if SBP mmHg ≤80 Ascites: 95% Discharge : 54 ± 20 90 days: 2 (11%) Rales: 65% 30 days : 59 ± 23 Hospitalizations: PND: 75%: 90 days : 58± 28 3 months prior to UF: 10 JVD: 95% SCr hospitalizations in 9 patients Sacral edema: Baseline : 2.12 ± 30 days: 1 hospitalization 35% 0.6 for heart failure Discharge : 2.20 ± 0.8 30 days : 2.38 ± 1.1 90 days : 58 ± 28 Liang/2006 Single-arm, 11 System 100 Goal: 4 L removal Baseline SCr: 2.2 Fluid removal achieved: open label per 8 hour UF mg/dL (27) >3500 mL: 13 (41%) session; 32 Baseline eGFR: 38 treatments in 11 2500-3500 mL: 11 (34%) mL/min patients <2500 mL: 8 (25%) Increase in SCr ≥0.3 mg/dL: 5 (45%) Aborted due to hypotension: 1 (3%) Dialysis for persistent diuretic resistant volume overload or uremic symptoms: 5 (45%) Six mortality: 55%
Costanzo/2005 (26) Single-arm, open label 20 75% ischemic 31 ± 15% (range 10% to 65%) IV: 39% Peripheral edema: 80% Ascites: 95% Rales: 65% PND: 75%: JVD: 95% Sacral edema: 35% Max rate 500 cc/hr, reduced to 200 cc/hr if SBP ≤80 mmHg BUN Baseline: 53 ± 18 Discharge : 54 ± 20 30 days : 59 ± 23 90 days : 58± 28 SCr Baseline : 2.12 ± 0.6 Discharge : 2.20 ± 0.8 30 days : 2.38 ± 1.1 90 days : 58 ± 28 90 days NYHA class IV: 30 days: 1 (5%) 90 days: 2 (11%) Hospitalizations: 3 months prior to UF: 10 hospitalizations in 9 patients 30 days: 1 hospitalization for heart failure Liang/2006 (27) Single-arm, open label 11 System 100 Goal: 4 L removal per 8 hour UF session; 32 treatments in 11 patients Baseline SCr: 2.2 mg/dL Baseline eGFR: 38 mL/min Increase in SCr ≥0.3 mg/dL: 5 (45%) Dialysis for persistent diuretic resistant volume overload or uremic symptoms: 5 (45%) Six mortality: 55% Fluid removal achieved: >3500 mL: 13 (41%) 2500-3500 mL: 11 (34%) <2500 mL: 8 (25%) Aborted due to hypotension: 1 (3%)
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