Table S2. Incidence of mutations in control rats from multiple NTP studies and Tp53 TBBA-exposed rats, as reported in the final NTP study report (NTP, 2014b), and a publication using data from the same NTP study (Harvey et al., 2015). Final Report Publication Treatment Group (NTP, 2014) (Harvey et al., 2015) Controls 1/9 2/10 250 mg/kg 3/3 Not Provided 500 mg/kg 3/7 Not Provided 1000 mg/kg 4/6 Not Provided All Treated 10/16 15/22 p-value (control vs. all treated)1 < 0.05 Not Conducted Mutation type included in Only Not Provided frequency count Functional 1p-value (reported by NTP) generated with one-sided Fisher’s exact test Table S3. Statistical results comparing mutation incidences between individual Tp53 TBBPA dose groups. P-values are listed comparing the incidence of mutation in Tp53 each dose group against the control group, calculated in the current investigation as based off the one-sided Fisher Exact test. Statistics could not be fully carried out using data from the peer-reviewed publication, as data were not provided for individual treatment groups. Final Report Publication Treatment Group (NTP, 2014) (Harvey et al., 2015) 250 mg/kg 0.018 Data Not Provided 500 mg/kg 0.192 Data Not Provided 1000 mg/kg 0.047 Data Not Provided All Treated 0.017 0.015 500 mg/kg and 0.052 Data Not Provided 1000 mg/kg
Table S2. Incidence of Tp53 mutations in control rats from multiple NTP studies and TBBA-exposed rats, as reported in the final NTP study report (NTP, 2014b), and a publication using data from the same NTP study (Harvey et al., 2015). Treatment Group Final Report (NTP, 2014) Publication (Harvey et al., 2015) Controls 1/9 2/10 250 mg/kg 3/3 Not Provided 500 mg/kg 3/7 Not Provided 1000 mg/kg 4/6 Not Provided All Treated 10/16 15/22 p-value (control vs. all treated)1 < 0.05 Not Conducted Mutation type included in frequency count Only Functional Not Provided 1p-value (reported by NTP) generated with one-sided Fisher’s exact test Table S3. Statistical results comparing Tp53 mutation incidences between individual TBBPA dose groups. P-values are listed comparing the incidence of Tp53 mutation in each dose group against the control group, calculated in the current investigation as based off the one-sided Fisher Exact test. Statistics could not be fully carried out using data from the peer-reviewed publication, as data were not provided for individual treatment groups. Treatment Group Final Report (NTP, 2014) Publication (Harvey et al., 2015) 250 mg/kg 0.018 Data Not Provided 500 mg/kg 0.192 Data Not Provided 1000 mg/kg 0.047 Data Not Provided All Treated 0.017 0.015 500 mg/kg and 1000 mg/kg 0.052 Data Not Provided
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