Total brain Intercept 1097.77 (971.75-1223.79) <0.0005 volume -72.64 (-143.19- -2.10) 0.044 Group [0 ESES patients, 1 refractory ESES patients 15.61 (3.08-28.13) 0.016 epilepsy] versus Age [years] refractory epilepsy controls Total brain Intercept 1019.31 (923.09-1115.53) <0.0005 volume 121.41 (61.91-180.91) <0.0005 Group [0 refractory, 1 healthy Refractory 16.28 (6.50-26.06) 0.001 control] epilepsy Age [years] controls versus healthy controls Supplementary Figure 2. Graphic representation of volumes (y axis) over age (x axis). A. Left thalamic volume. B. Right thalamic volume. C. Total brain volume. Individual observations are represented as circles with their respective best fit curves. Green: ESES patients. Blue: Healthy controls. Red: Refractory epilepsy controls. ABSOLUTE THALAMIC VOLUMES CORRECTING FOR AGE AND BRAIN VOLUME IN THE REGRESSION MODEL The main comparison was performed correcting for total brain volume using the relative thalamic volume (Table 2 and Figure 2). Correcting for total brain volume using it as a regressor in the regression model yielded similar results. Correcting for total brain volume using it as a
Total brain volume ESES patients versus refractory epilepsy controls Intercept Group [0 ESES patients, 1 refractory epilepsy] Age [years] 1097.77 (971.75-1223.79) -72.64 (-143.19- -2.10) 15.61 (3.08-28.13) <0.0005 0.044 0.016 Total brain volume Refractory epilepsy controls versus healthy controls Intercept Group [0 refractory, 1 healthy control] Age [years] 1019.31 (923.09-1115.53) 121.41 (61.91-180.91) 16.28 (6.50-26.06) <0.0005 <0.0005 0.001 Supplementary Figure 2. Graphic representation of volumes (y axis) over age (x axis). A. Left thalamic volume. B. Right thalamic volume. C. Total brain volume. Individual observations are represented as circles with their respective best fit curves. Green: ESES patients. Blue: Healthy controls. Red: Refractory epilepsy controls. ABSOLUTE THALAMIC VOLUMES CORRECTING FOR AGE AND BRAIN VOLUME IN THE REGRESSION MODEL The main comparison was performed correcting for total brain volume using the relative thalamic volume (Table 2 and Figure 2). Correcting for total brain volume using it as a regressor in the regression model yielded similar results. Correcting for total brain volume using it as a
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