Asthma-related Asthma-related Asthma-related mortality rate = 0.4 De Vries et al De Vries et al mortality rate = 0.4 deaths per 100 (2010) () (2010) () per 100 person-years HRQoL No HRQoL difference HRQoL difference between treatments observed in the EXALT Omalizumab up to age 12. 0.761 (omalizumab) hospitalisation effect on HRQoL hospitalisation () From age 12, HRQoL versus 0.631 () difference as adults (standard care) and adolescents. loss due to CSNS = -0.10 Lloyd et al (2007) CSNS = -0.10 Lloyd et al exacerbations CSS = -0.20 () CSS = -0.20 (2007) () Duration of Lloyd et al (2007) Lloyd et al 4 weeks 4 weeks exacerbation () (2007) () Resource use and costs INNOVATE IA-05 EUP() hospitalisation() NHS Cost of CSNS = £154.70 NHS Reference Reference CSNS=CSS=£213.89 exacerbations CSS = £178.87 () () PSSRU Unit costs PSSRU Unit () costs () 2 per year, £160 2 per year, £190 Routine visits NHS each NHS reference each reference Initiation of costs () costs () £245 £247 therapy Standard therapy costs £1,197 INNOVATE() £810 IA-05 EUP() (per year)
Asthma-related deaths Asthma-related mortality rate = 0.4 per 100 De Vries et al (2010) () Asthma-related mortality rate = 0.4 per 100 person-years De Vries et al (2010) () HRQoL Omalizumab effect on HRQoL HRQoL difference observed in the 0.761 (omalizumab) versus 0.631 (standard care) hospitalisation () No HRQoL difference between treatments up to age 12. From age 12, HRQoL difference as adults and adolescents. EXALT hospitalisation () loss due to exacerbations CSNS = -0.10 CSS = -0.20 Lloyd et al (2007) () CSNS = -0.10 CSS = -0.20 Lloyd et al (2007) () Duration of exacerbation 4 weeks Lloyd et al (2007) () 4 weeks Lloyd et al (2007) () Resource use and costs Cost of exacerbations CSNS = £154.70 CSS = £178.87 INNOVATE hospitalisation() NHS Reference () PSSRU Unit costs () CSNS=CSS=£213.89 IA-05 EUP() NHS Reference () PSSRU Unit costs () Routine visits 2 per year, £160 each NHS reference costs () 2 per year, £190 each NHS reference costs () Initiation of therapy £245 £247 Standard therapy costs (per year) £1,197 INNOVATE() £810 IA-05 EUP()
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