prednisone prednisone prednisone equivalents equivalents equivalents Hormone Hormone Hormone replacement therapy replacement therapy replacement therapy as clinically indicated as clinically indicated as clinically indicated Withhold immune Withhold or Permanently checkpoint therapy discontinue immune discontinue immune checkpoint therapy checkpoint therapy Thyroid Hypothyroidism Hormone Hormone Hormone and replacement therapy replacement therapy replacement therapy hyperthyroidism for hypothyroidism for hypothyroidism for hypothyroidism Initiate immediate Initiate immediate Initiate immediate medical medical medical management for management for management for hyperthyroidism as hyperthyroidism hyperthyroidism appropriate Withhold or Permanently No recommended discontinue immune discontinue immune dose adjustments for checkpoint therapy checkpoint therapy immune checkpoint therapy Adrenal Adrenal Withhold immune Corticosteroids at Corticosteroids at insufficiency checkpoint therapy mg/kg/day mg/kg/day prednisone prednisone equivalents equivalents Permanently Permanently discontinue immune discontinue immune checkpoint therapy checkpoint therapy Pancreas Type 1 Insulin for type 1 Insulin for type 1 Insulin for type 1 diabetes diabetes diabetes diabetes mellitus Withhold immune Permanently checkpoint therapy discontinue immune and administer checkpoint therapy for for hyperglycemia hyperglycemia aBased on available management guidelines and prescribing information [35,37,38,40,41].
prednisone equivalents Hormone replacement therapy as clinically indicated Withhold immune checkpoint therapy prednisone equivalents Hormone replacement therapy as clinically indicated Withhold or discontinue immune checkpoint therapy prednisone equivalents Hormone replacement therapy as clinically indicated Permanently discontinue immune checkpoint therapy Thyroid Hypothyroidism and hyperthyroidism Hormone replacement therapy for hypothyroidism Initiate immediate medical management for hyperthyroidism as appropriate No recommended dose adjustments for immune checkpoint therapy Hormone replacement therapy for hypothyroidism Initiate immediate medical management for hyperthyroidism Withhold or discontinue immune checkpoint therapy Hormone replacement therapy for hypothyroidism Initiate immediate medical management for hyperthyroidism Permanently discontinue immune checkpoint therapy Adrenal Adrenal insufficiency Withhold immune checkpoint therapy Corticosteroids at mg/kg/day prednisone equivalents Permanently discontinue immune checkpoint therapy Corticosteroids at mg/kg/day prednisone equivalents Permanently discontinue immune checkpoint therapy Pancreas Type 1 diabetes mellitus Insulin for type 1 diabetes Insulin for type 1 diabetes Withhold immune checkpoint therapy and administer for hyperglycemia Insulin for type 1 diabetes Permanently discontinue immune checkpoint therapy for hyperglycemia aBased on available management guidelines and prescribing information [35,37,38,40,41].
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