PNEC applied = 0.089 µg/L (JRC 2016). 8 metformin Anti diabetic Very high usage PNEC applied = 13.45 µg/L; Daphnia acute EC50 of 1345 µg/L / AF = 100 (data from UKWIR 2014). 9 ranitidine Anti indigestion Over counter, proton pump inhibitor high usage PNEC applied = 0.31 µg/L; Daphnia acute EC50 of 310 µg/L / AF = 1000 (data from UKWIR 2014). 10 carbamazepine Mood stabilising Established EU anticonvulsant concern 10,11- epoxycarbamazepine PNEC applied = 2.5 µg/L; Daphnia chronic EC10 of 25 µg/L / AF = 10 (data from 2014). 11 sertraline / SSRI antidepressant Sludge risk norsertraline PNEC applied = 0.121 µg/L; Algal acute EC50 of 12.1 µg/L / AF = 100 (data from UKWIR 2014). 12 fluoxetine Antidepressant Low removal Established concern in CIP1 PNEC applied = 0.047 µg/L; Snail chronic NOEC of 0.47
PNEC applied = 0.089 µg/L (JRC 2016). 8 metformin Anti diabetic Very high usage PNEC applied = 13.45 µg/L; Daphnia acute EC50 of 1345 µg/L / AF = 100 (data from UKWIR 2014). 9 ranitidine Anti indigestion proton pump inhibitor Over counter, high usage PNEC applied = 0.31 µg/L; Daphnia acute EC50 of 310 µg/L / AF = 1000 (data from UKWIR 2014). 10 carbamazepine 10,11- epoxycarbamazepine Mood stabilising anticonvulsant Established EU concern PNEC applied = 2.5 µg/L; Daphnia chronic EC10 of 25 µg/L / AF = 10 (data from 2014). 11 sertraline / norsertraline SSRI antidepressant Sludge risk PNEC applied = 0.121 µg/L; Algal acute EC50 of 12.1 µg/L / AF = 100 (data from UKWIR 2014). 12 fluoxetine Antidepressant Low removal Established concern in CIP1 PNEC applied = 0.047 µg/L; Snail chronic NOEC of 0.47
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