Number of Memorial Sloan-Kettering Cancer Centre RCC prognostic criteria: Karnofsky performance status score < 80% Haemoglobin < 13 g/dL (< 130 g/L) for males and < 11.5 g/dL (< 115 g/L) in females Corrected calcium > limit of normal Baseline characteristics of the OS population from the published article are described in the table below (Table 16). Table 16: Study XL184-308 Baseline characteristics of the OS population from the NEJM article Cabozantinib Everolimus n=328 n=330 Age, Md (range) 63 (32, 86) 62 (31, 84) Men 77% 73% ECOG 0 68% 66% ECOG 1 32% 34% MSKCC prognostic risk cat Favourable 45% 46% Intermediate 42% 41% Poor 12% 13% Prior VEGFR TKI 1 71% 70% 2+ 29% 30% Previous systemic therapy Sunitinib 64% 62% Pazopanib 44% 41% Axitinib 16% 17% Sorafenib 6% 9% Beva 2% 3% Interleukin-2 6% 9% Interferon alpha 6% 7% Nivo 5% 4% RT 33% 33% Nephrectomy 85% 85% Baseline data and deviations were generally balanced across arms. There was a higher rate of discontinuation in the everolimus arm; the imbalance was mainly due to
Number of Memorial Sloan-Kettering Cancer Centre RCC prognostic criteria: Karnofsky performance status score < 80% Haemoglobin < 13 g/dL (< 130 g/L) for males and < 11.5 g/dL (< 115 g/L) in females Corrected calcium > limit of normal Baseline characteristics of the OS population from the published article are described in the table below (Table 16). Table 16: Study XL184-308 Baseline characteristics of the OS population from the NEJM article Cabozantinib n=330 Everolimus n=328 Age, Md (range) 63 (32, 86) 62 (31, 84) Men 77% 73% ECOG 0 ECOG 1 68% 32% 66% 34% MSKCC prognostic risk cat Favourable Intermediate Poor 45% 42% 12% 46% 41% 13% Prior VEGFR TKI 1 2+ 71% 29% 70% 30% Previous systemic therapy Sunitinib Pazopanib Axitinib Sorafenib Beva Interleukin-2 Interferon alpha Nivo 64% 44% 16% 6% 2% 6% 6% 5% 62% 41% 17% 9% 3% 9% 7% 4% RT 33% 33% Nephrectomy 85% 85% Baseline data and deviations were generally balanced across arms. There was a higher rate of discontinuation in the everolimus arm; the imbalance was mainly due to
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