SUPPLEMENTAL TABLES Supplemental table 1 IP1 pEC50 Base Receptor Agonist N (EC50 (%) μM) mGlu3 WT - 38,76 ± 3,00 3 4,79 ± 0,07 mGlu2 WT 100,00 ± 0,00 3 (16,22) Glutamate 4,56 ± 0,08 148,47 ± 12,48 3 VFT2/TMD3 (27,54) - 41,69 ± 4,57 3 VFT3/TMD2 TR-FRET sensor pEC50 Base Receptor Agonist N (EC50 (%) μM) 5,30 ± 0,14 mGlu3 WT 15,22 ± 3,01 3 (5,01) 4,99 ± 0,13 mGlu2 WT 100,00 ± 0,00 3 (10,23) Glutamate 4,71 ± 0,16 111,27 ± 1,19 3 VFT2/TMD3 (19,50) 6,06 ± 0,08 7,84 ± 2,22 3 VFT3/TMD2 (0,87) Supplemental table 1: Concentration-response curves parameters of mGlu2-mGlu3 chimeras.
SUPPLEMENTAL TABLES Supplemental table 1 IP1 Receptor Agonist pEC50 (EC50 μM) Base (%) N mGlu3 WT Glutamate - 38,76 ± 3,00 3 mGlu2 WT 4,79 ± 0,07 (16,22) 100,00 ± 0,00 3 VFT2/TMD3 4,56 ± 0,08 (27,54) 148,47 ± 12,48 3 VFT3/TMD2 - 41,69 ± 4,57 3 TR-FRET sensor Receptor Agonist pEC50 (EC50 μM) Base (%) N mGlu3 WT Glutamate 5,30 ± 0,14 (5,01) 15,22 ± 3,01 3 mGlu2 WT 4,99 ± 0,13 (10,23) 100,00 ± 0,00 3 VFT2/TMD3 4,71 ± 0,16 (19,50) 111,27 ± 1,19 3 VFT3/TMD2 6,06 ± 0,08 (0,87) 7,84 ± 2,22 3 Supplemental table 1: Concentration-response curves parameters of mGlu2-mGlu3 chimeras.
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