Biology of Blood Diseases (BIOL 426) SSII 2013 Chantelle Rein-Smith, Ph.D. crein@email.unc.edu Instructor: – Course Meeting Times: M,T,W,Th,F 1:15-2:45 pm Office Hours: M, W, F 9:30-11:30am, or by appointment Textbook: Haematology”, 6th Edition, Hoffbrand and “Essential Moss (Recommended) This course focuses on the molecular mechanisms associated with normal and pathogenic functions of blood, blood cells and bone marrow. We will examine multiple areas of hematology and oncology including anemias, cancer, blood coagulation disorders, and atherosclerosis. We will begin each unit by focusing on the origins of blood cells and biological “normal” processes of blood/bone marrow, and then transition to diseases and pathologies associated with each blood cell type. We will utilize in-class lectures, case studies, clubs” and group activities to achieve the “journal overall course goal of understanding the biological basis of hematological disease. Course Objectives: Understand the normal function of blood cells and how alterations in function lead to pathology Identify normal and pathological blood cells in blood smears and bone marrow biopsies Interpret the results of complete blood counts (CBCs) and specific laboratory tests related to blood diseases Classify different diseases of the blood according to cellular abnormalities and test results Create a Journal Club Presentations: Each Friday the second half of class will be devoted to a club” presentation. Each small group will select a “journal current journal article (published within the last 5 years in a peer reviewed journal and approved by the instructor) on one of the class topics. Groups will present their articles in a 15-20 minute club” format each “journal designated class. All others should come prepared with questions about the paper. Journal clubs are peer graded and are also graded by the instructor. More information about creating a journal club presentation can be found on the course Sakai site.
Biology of Blood Diseases (BIOL 426) SSII 2013 Instructor: Chantelle Rein-Smith, Ph.D. – crein@email.unc.edu Course Meeting Times: M,T,W,Th,F 1:15-2:45 pm Office Hours: M, W, F 9:30-11:30am, or by appointment Textbook: “Essential Haematology”, 6th Edition, Hoffbrand and Moss (Recommended) This course focuses on the molecular mechanisms associated with normal and pathogenic functions of blood, blood cells and bone marrow. We will examine multiple areas of hematology and oncology including anemias, cancer, blood coagulation disorders, and atherosclerosis. We will begin each unit by focusing on the origins of blood cells and “normal” biological processes of blood/bone marrow, and then transition to diseases and pathologies associated with each blood cell type. We will utilize in-class lectures, case studies, “journal clubs” and group activities to achieve the overall course goal of understanding the biological basis of hematological disease. Course Objectives: Understand the normal function of blood cells and how alterations in function lead to pathology Identify normal and pathological blood cells in blood smears and bone marrow biopsies Interpret the results of complete blood counts (CBCs) and specific laboratory tests related to blood diseases Classify different diseases of the blood according to cellular abnormalities and test results Create a Journal Club Presentations: Each Friday the second half of class will be devoted to a “journal club” presentation. Each small group will select a current journal article (published within the last 5 years in a peer reviewed journal and approved by the instructor) on one of the class topics. Groups will present their articles in a 15-20 minute “journal club” format each designated class. All others should come prepared with questions about the paper. Journal clubs are peer graded and are also graded by the instructor. More information about creating a journal club presentation can be found on the course Sakai site.
BIOL426-Rein-Smith-SS2-2013.docx