relationships were demonstrated for pleural plaques, while only dose-response relationships were demonstrated for asbestosis. Reid et al RMA ID: The Effect of 1988 (1196 former Crocidolite Cumulative Duration of Morbidity study reporting (2005) 037507 Asbestosis on Wittenoom workers; mine/mill exposure: Cases exposure (days): asbestos exposure Lung Cancer 792 residents of (n=58 lung (n=58 lung producing asbestosis in Risk Beyond the Wittenoom) cancer cancer): M=11 cancer): M=330 lung cancer patients. 58 Dose Related prevention program (range=2.6-46.5) (range=118-1048) lung cancer cases 21; Effect of participants fibre/mL-year days 36% had radiographic Asbestos Alone Controls(n=1930 asbestosis compared to 58=lung cancer Controls (n=1930 non-cases): M=285 220 (11%) of participants. asbestosis) non-cases): M=5 (range=106-854) Radiographic asbestosis (range=1.8-13.5) 1930=non-cases days (OR=1.94, 95% Cl: 1.09, fibre/mL-year (220=asbestosis) 3.46) and asbestos Concentration of exposure (OR=1.21 per exposure: fibre/mL-year, 95% Cl: (n=58 lung 1.02, 1.42) significantly cancer): M=12 associated with an (range=6.2-40.3) increased risk of lung fibre/mL cancer. Intensity of Controls: (n=1930 exposure and cumulative M=6 exposure were both (range=2.1-20.3) statistically significant. fibre/mL The interaction between cumulative asbestos exposure and asbestosis was not significant (Hazard Ratio = 0.82, 95% CI: 0.59, 1.13, = p 0.23). Author’s
relationships were demonstrated for pleural plaques, while only dose-response relationships were demonstrated for asbestosis. Reid et al (2005) RMA ID: 037507 The Effect of Asbestosis on Lung Cancer Risk Beyond the Dose Related Effect of Asbestos Alone 1988 (1196 former Wittenoom workers; 792 residents of Wittenoom) cancer prevention program participants 58=lung cancer asbestosis) 1930=non-cases (220=asbestosis) Crocidolite mine/mill Cumulative exposure: Cases (n=58 lung cancer): M=11 (range=2.6-46.5) fibre/mL-year Controls (n=1930 non-cases): M=5 (range=1.8-13.5) fibre/mL-year Concentration of exposure: (n=58 lung cancer): M=12 (range=6.2-40.3) fibre/mL Controls: (n=1930 M=6 (range=2.1-20.3) fibre/mL Duration of exposure (days): (n=58 lung cancer): M=330 (range=118-1048) days Controls(n=1930 non-cases): M=285 (range=106-854) days Morbidity study reporting asbestos exposure producing asbestosis in lung cancer patients. 58 lung cancer cases 21; 36% had radiographic asbestosis compared to 220 (11%) of participants. Radiographic asbestosis (OR=1.94, 95% Cl: 1.09, 3.46) and asbestos exposure (OR=1.21 per fibre/mL-year, 95% Cl: 1.02, 1.42) significantly associated with an increased risk of lung cancer. Intensity of exposure and cumulative exposure were both statistically significant. The interaction between cumulative asbestos exposure and asbestosis was not significant (Hazard Ratio = 0.82, 95% CI: 0.59, 1.13, p = 0.23). Author’s
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