PART 4 SUMMARY OF EVIDENCE – Provide an overview of all key journal articles or research published in the public domain related to the proposed service that is for your application (limiting these to the English language only). Please do not attach full text articles, this is just intended to be a summary. Probably the best evidence for the use of SIR-Spheres Y-90 resin microspheres for Metastatic Breast Cancer is: Type of study design* Title of journal article or Short description of research (max 50 Website link to journal Date of research project (including words)** article or research (if publication*** any identifier or study available) lead if relevant) 1. Single-centre Saxena A, Kapoor J, Meteling B Forty patients underwent resin-based Y90 Listed on Pubmed 2014 experience et al. Yttrium-90 radioembolization for unresectable, radioembolization for chemoresistant BRCLM in a single institution. unresectable, chemoresistant All patients were followed up with imaging breast cancer liver metastases: studies at regular intervals as clinically A large single-center indicated until death. Radiologic response experience of 40 patients. was evaluated with the Response Criteria in Annals of Surgical Oncology Solid Tumors criteria. Clinical toxicities were 2014; 21: 1296–1303. prospectively recorded. Survival was calculated by the Kaplan-Meier method. This study provides supportive evidence of the safety and efficacy. Probably the best evidence for the use of SIR-Spheres Y-90 resin microspheres for Metastatic Neuroendocrine Tumours (NETs) is: Type of study design* Title of journal article or Short description of research (max 50 Website link to journal Date of research project (including words)** article or research (if publication*** any trial identifier or study available) lead if relevant)
PART 4 – SUMMARY OF EVIDENCE Provide an overview of all key journal articles or research published in the public domain related to the proposed service that is for your application (limiting these to the English language only). Please do not attach full text articles, this is just intended to be a summary. Probably the best evidence for the use of SIR-Spheres Y-90 resin microspheres for Metastatic Breast Cancer is: Type of study design* Title of journal article or research project (including any identifier or study lead if relevant) Short description of research (max 50 words)** Website link to journal article or research (if available) Date of publication*** 1. Single-centre experience Saxena A, Kapoor J, Meteling B et al. Yttrium-90 radioembolization for unresectable, chemoresistant breast cancer liver metastases: A large single-center experience of 40 patients. Annals of Surgical Oncology 2014; 21: 1296–1303. Forty patients underwent resin-based Y90 radioembolization for unresectable, chemoresistant BRCLM in a single institution. All patients were followed up with imaging studies at regular intervals as clinically indicated until death. Radiologic response was evaluated with the Response Criteria in Solid Tumors criteria. Clinical toxicities were prospectively recorded. Survival was calculated by the Kaplan-Meier method. This study provides supportive evidence of the safety and efficacy. Listed on Pubmed 2014 Probably the best evidence for the use of SIR-Spheres Y-90 resin microspheres for Metastatic Neuroendocrine Tumours (NETs) is: Type of study design* Title of journal article or research project (including any trial identifier or study lead if relevant) Short description of research (max 50 words)** Website link to journal article or research (if available) Date of publication***
Application%20Form%20-%20SIR%20Spheres%20-%20other%20indications%20-%20Jan'17.docx