Very common ♦ Cough Dysphonia Common Common Very common ♦ Dyspnoea Common ♦ Pnuemothorax Gastrointestinal disorders Very common Very common Abdominal pain Very common Very common Diarrhoea Common Common Dyspepsia Uncommon ♦ Gastrointestinal perforation* Uncommon Uncommon Gastrointestinal fistula* Common ♦ Lipase elevations‡ Very common Very common Nausea Very common ♦ Stomatitis Very common Very common Vomiting Hepatobiliary disorders Very common Common Alanine transferase increased Very common Common Aspartate amino transferase increased Common ♦ Hepatic function abnormal Common Uncommon Hyperbilirubinaemia Skin and subcutaneous tissue disorders Alopecia Common Very common Dry Skin Common ♦ Exfoliative rash Very common ♦ Hair depigmentation Very common Very common Nail disorder Common ♦ Palmar-plantar Common Very common erythrodysesthesia syndrome Rash Common Uncommon Skin depigmentation Common Very common
Cough ♦ Very common Dysphonia Common Common Dyspnoea ♦ Very common Pnuemothorax ♦ Common Gastrointestinal disorders Abdominal pain Very common Very common Diarrhoea Very common Very common Dyspepsia Common Common Gastrointestinal perforation* Uncommon ♦ Gastrointestinal fistula* Uncommon Uncommon Lipase elevations‡ Common ♦ Nausea Very common Very common Stomatitis ♦ Very common Vomiting Very common Very common Hepatobiliary disorders Alanine transferase increased Very common Common Aspartate amino transferase increased Very common Common Hepatic function abnormal Common ♦ Hyperbilirubinaemia Common Uncommon Skin and subcutaneous tissue disorders Alopecia Common Very common Dry Skin ♦ Common Exfoliative rash ♦ Very common Hair depigmentation Very common Very common Nail disorder ♦ Common Palmar-plantar erythrodysesthesia syndrome Common Very common Rash Common Uncommon Skin depigmentation Common Very common
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