Organ/system 0 1 2 3 4 Liver <1.2 to to < to < 12.0 ≥1.2 ≤ ≥2.0 ≥6.0 ≥12.0 2.0 6.0 (Bilirubin, mg/dL) Kidney <1.2 to < to < to < 5.0 5 ≥1.2 ≥2.0 ≥3.5 ≥ 2.0 3.5 or use of renal (creatinine mg/dL) replacement therapy Cerebral No HE I II III IV (HE grade) Coagulation >1.1 to < to < to < 2.5 or platelet ≥1.1 ≥1.25 ≥1.5 ≥2.5 1.25 1.5 20 x 109 ≤ (international /L normalized ratio) Circulation 70 < 70 Dopamine Dopamine > 5 Dopamine > 15 ≥ ≤ 5 or or or (mean arterial pressure, mm Hg) dobutamine Epinephrine Epinepfrine >0.1 or ≤0.1 or or Norepinephrine terlipressin Norepinephrine 0.1 ≤ > 0.1 Lungs PaO2/FiO2 > 400 > 300 to > 200 to > 100 to 200 100 ≤ ≤ ≤ ≤ 400 300 SpO2/FiO2 > 512 > 357 to > 214 to > 89 to 214 89 ≤ ≤ ≤ ≤ 512 357
Organ/system 0 1 2 3 4 Liver (Bilirubin, mg/dL) <1.2 ≥1.2 to ≤ 2.0 ≥2.0 to < 6.0 ≥6.0 to < 12.0 ≥12.0 Kidney (creatinine mg/dL) <1.2 ≥1.2 to < 2.0 ≥2.0 to < 3.5 ≥3.5 to < 5.0 or use of renal replacement therapy ≥ 5 Cerebral (HE grade) No HE I II III IV Coagulation (international normalized ratio) >1.1 ≥1.1 to < 1.25 ≥1.25 to < 1.5 ≥1.5 to < 2.5 ≥2.5 or platelet ≤ 20 x 109 /L Circulation (mean arterial pressure, mm Hg) ≥ 70 < 70 Dopamine ≤ 5 or dobutamine or terlipressin Dopamine > 5 or Epinephrine ≤0.1 or Norepinephrine ≤ 0.1 Dopamine > 15 or Epinepfrine >0.1 or Norepinephrine > 0.1 Lungs PaO2/FiO2 > 400 > 300 to ≤ 400 > 200 to ≤ 300 > 100 to ≤ 200 ≤ 100 SpO2/FiO2 > 512 > 357 to ≤ 512 > 214 to ≤ 357 > 89 to ≤ 214 ≤ 89
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