Brain Mostafa et al. [30] ASD 84 Examined significant and positive Neuropeptides Metab Brain Dis Controls 84 linear relationship between in Serum neuropeptides levels of serum neurokinin 3-10 y and mercury in A and blood mercury in serum moderate and severe ASD, but not controls Oxidative Sajdel-Sulkowska ASD 9 Oxidative stress Significant increases in the Stress 3-NT et al. [31] Controls 10 marker 3-NT, mean cerebellar levels of – Am J Biochem mercury, and the NT and in the ratio of Biotechnol 5-37 y antioxidant mercury/selenium in the selenium in brains of subjects autism and diagnosed with autism controls when compared to controls; there was a significant dose-dependent positive correlation between oxidative stress markers and total mercury levels ASD= autism spectrum disorders; anti-MBP= anti myelin basic protein; 3-NT =3-nitrotyrosine; EEG=electroencephalogram; y= years of age Studies that did Show Brain Mercury Levels were Different in Children with ASD vs. Controls Table 2. not Biomarker Authors and N Purpose of Study Findings Journal Age Brain Khan et al. [32] ASD 10 Brain mercury Brain mercury levels J Physiol Controls 11 levels measured in measured in extracortical Pharmacol extracortical regions in children with 4-16 y regions autism vs. autism vs. controls were not controls different
Brain Neuropeptides in Serum Mostafa et al. [30] Metab Brain Dis ASD 84 Controls 84 3-10 y Examined neuropeptides and mercury in serum significant and positive linear relationship between levels of serum neurokinin A and blood mercury in moderate and severe ASD, but not controls Oxidative Stress – 3-NT Sajdel-Sulkowska et al. [31] Am J Biochem Biotechnol ASD 9 Controls 10 5-37 y Oxidative stress marker 3-NT, mercury, and the antioxidant selenium in autism and controls Significant increases in the mean cerebellar levels of and in the ratio of mercury/selenium in the brains of subjects diagnosed with autism when compared to controls; there was a significant dose-dependent positive correlation between oxidative stress markers and total mercury levels ASD= autism spectrum disorders; anti-MBP= anti myelin basic protein; 3-NT =3-nitrotyrosine; EEG=electroencephalogram; y= years of age Table 2. Studies that did not Show Brain Mercury Levels were Different in Children with ASD vs. Controls Biomarker Authors and Journal N Age Purpose of Study Findings Brain Khan et al. [32] J Physiol Pharmacol ASD 10 Controls 11 4-16 y Brain mercury levels measured in extracortical regions autism vs. controls Brain mercury levels measured in extracortical regions in children with autism vs. controls were not different NT
1-s2.0-S0946672X16300931-mmc1.docx