Outcomes: pain and sleep Supplement), 23(10), in another 7 patients. diary, healing S24, 26-31 Patients and carers were able to change the dressings themselves. Limitations: small, uncontrolled study Silicone-based Mepitel® film Randomised controlled Hers, P., Bennett, N., The study reported 0% moist 0 transparent film trial comparing Sutherland, A., desquamation rates for the prophylactic Mepitel® film Peszynski, R., Mepitel® covered areas and with Aqueous cream BP Paterson, D., 26% for the control areas (patients as own control) Jasperse, M. 2014. (p<0.0001). during RT for breast Prophylactic use of Mepitel® film significantly cancer Mepitel® film prevents decreased the combined, N = 80 radiation-induced researcher and patients Outcomes: skin reaction moist desquamation RISRAS severity, incidence of in an intra-patient scores (p < 0.0001) by 92% moist desquamation randomised controlled (compared with the Aqueous clinical trial of 78 cream BP areas). The breast cancer majority of patients (n=55) patients. preferred Mepitel® film to Radiotherapy and cream because it felt Oncology 110:1, comfortable and protective. Limitations: as with other patient’ trials, it was ‘within impossible to blind the trial. Non adhesive Silver clear Randomised controlled Niazi, T., Vuong, T., Mean dermatitis score on the last ++ nylon trial Phase III study Azoulay, L., Marijnen, day of RT (assumed to be the – dressing comparing silver clear C., Bujko, K., Nasr, E. point at which skin reactions (SCND) nylon dressing with et al. 2012. Silver were at their worst) was 2.53 sulfadiazine cream in clear (standard deviation [SD], 1.17)
Outcomes: pain and sleep diary, healing Supplement), 23(10), S24, 26-31 in another 7 patients. Patients and carers were able to change the dressings themselves. Limitations: small, uncontrolled study Silicone-based transparent film Mepitel® film Randomised controlled trial comparing prophylactic Mepitel® film with Aqueous cream BP (patients as own control) during RT for breast cancer N = 80 Outcomes: skin reaction severity, incidence of moist desquamation Hers, P., Bennett, N., Sutherland, A., Peszynski, R., Paterson, D., Jasperse, M. 2014. Prophylactic use of Mepitel® film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Radiotherapy and Oncology 110:1, The study reported 0% moist desquamation rates for the Mepitel® covered areas and 26% for the control areas (p<0.0001). Mepitel® film significantly decreased the combined, researcher and patients RISRAS scores (p < 0.0001) by 92% (compared with the Aqueous cream BP areas). The majority of patients (n=55) preferred Mepitel® film to cream because it felt comfortable and protective. Limitations: as with other ‘within patient’ trials, it was impossible to blind the trial. 0 Non adhesive Silver clear nylon dressing (SCND) Randomised controlled trial – Phase III study comparing silver clear nylon dressing with sulfadiazine cream in Niazi, T., Vuong, T., Azoulay, L., Marijnen, C., Bujko, K., Nasr, E. et al. 2012. Silver clear Mean dermatitis score on the last day of RT (assumed to be the point at which skin reactions were at their worst) was 2.53 (standard deviation [SD], 1.17) ++
appendix_9_-_dressings_table.docx