paper, or filtration under reduced pressure; AT k). 3.3.9.2 Acylation Time Learning activity with opportunity to Assessment Learning outcome Resources Learning objective taken develop skills opportunities Draw the structure of and 2.0 RSC resource on aspirin: Students draw and name acid January 2012 Unit 4 Students should be able to: name acid anhydrides, acyl weeks anhydrides, acyl chlorides and Question 10a draw the structure of and amides (AO2 - Apply knowledge and (QW12.4.10) chlorides and amides. Aspirin Pre-lab Screen name acid anhydrides, acyl understanding). June 2006 Unit 4 Experiment: chlorides and amides Students write equations and outline Question 1 Understand acylation identify the products of and mechanisms for acylation reactions (QS06.4.01) reactions of water, equations for acylation of water, alcohols, ammonia and June 2005 Unit 4 alcohols, ammonia and reactions of water, amines with acyl chlorides and acid Question 7 alcohols, ammonia and amines with acyl chlorides anhydrides; some of these reactions (QS05.4.07) amines with acyl chlorides and acid anhydrides, could be demonstrated. and acid anhydrides June 2003 Unit 5 including the mechanism RSC mechanisms Students prepare, purify and test the Question 8b outline the mechanism for for acyl chlorides. resource: purity of aspirin by melting point (QS03.5.08) the acylation reactions of determination (AO2 - Apply acyl chlorides Required practical 10 Mechanism animations knowledge and understanding; AT d state advantages of using - Use laboratory apparatus for a Preparation of ethanoic anhydride rather variety of experimental techniques - a pure organic solid and than ethanoyl chloride in including distillation and heating test of its purity the production of aspirin under reflux, including setting up - a pure organic liquid. prepare and purity an glassware using retort stand and organic and test its clamps; AT d - Use laboratory purity. apparatus for a variety of experimental techniques including
paper, or filtration under reduced pressure; AT k). 3.3.9.2 Acylation Learning objective Time taken Learning outcome Learning activity with opportunity to develop skills Assessment opportunities Resources Draw the structure of and name acid anhydrides, acyl chlorides and amides. Understand acylation reactions of water, alcohols, ammonia and amines with acyl chlorides and acid anhydrides, including the mechanism for acyl chlorides. Required practical 10 Preparation of - a pure organic solid and test of its purity - a pure organic liquid. 2.0 weeks Students should be able to: draw the structure of and name acid anhydrides, acyl chlorides and amides identify the products of and equations for acylation reactions of water, alcohols, ammonia and amines with acyl chlorides and acid anhydrides outline the mechanism for the acylation reactions of acyl chlorides state advantages of using ethanoic anhydride rather than ethanoyl chloride in the production of aspirin prepare and purity an organic and test its purity. Students draw and name acid anhydrides, acyl chlorides and amides (AO2 - Apply knowledge and understanding). Students write equations and outline mechanisms for acylation reactions of water, alcohols, ammonia and amines with acyl chlorides and acid anhydrides; some of these reactions could be demonstrated. Students prepare, purify and test the purity of aspirin by melting point determination (AO2 - Apply knowledge and understanding; AT d - Use laboratory apparatus for a variety of experimental techniques including distillation and heating under reflux, including setting up glassware using retort stand and clamps; AT d - Use laboratory apparatus for a variety of experimental techniques including January 2012 Unit 4 Question 10a (QW12.4.10) June 2006 Unit 4 Question 1 (QS06.4.01) June 2005 Unit 4 Question 7 (QS05.4.07) June 2003 Unit 5 Question 8b (QS03.5.08) RSC resource on aspirin: Aspirin Pre-lab Screen Experiment: RSC mechanisms resource: Mechanism animations
AQA-7405-SOW.DOCX