rubella infection in following: following: cataracts, least two of the immunoglobulin M antibody pregnancy detection of glaucoma, congenital following without a more OR positive rubella-specific heart disease, hearing plausible etiology: immunoglobulin G antibodies immunoglobulin M impairment, pigmentary -cataracts or congenital whose titre does not drop by at antibody retinopathy, purpura, glaucoma, least two fold within a 4 week OR positive hepatosplenomegaly, -congenital heart disease period specific jaundice, microcephaly, -hearing impairment, OR a specimen that is immunoglobulin G developmental delay, -pigmentary retinopathy; for rubella virus antibodies OR a meningoencephalitis, 2)An infant with no specimen that is radioluscent bone laboratory confirmation for rubella disease of rubella infection but at virus least one of the following without a more plausible etiology; -cataracts or congenital glaucoma, -congenital heart disease -hearing impairment, -pigmentary retinopathy; AND one or more of the following: -purpura, -hepatosplenomegaly, -jaundice, -microcephaly, -developmental delay, -meningoencephalitis, -radiolucent bone disease. Congenital syphilis A condition affecting an Early Infant or child < 2 years Infant or child < 2 years Probable case with confirmatory infant or child (< 2 years) who has a REACTIVE whose mother had laboratory tests on placenta/ Congenital whose mother had untreated Syphilis: non-treponemal test on untreated or amniotic fluid/ autopsy material/ or inadequately treated may present serum/ blood (RPR *inadequately treated exudates from suspicious lesions/ syphilis. anytime in POSITIVE) body fluids e.g. nasal discharge, syphilis at infancy or delivery,regardless of CSF early signs in infant childhood (< motile treponemes seen on ? Ante-natal clinic 2 years). OR darkfield microscopy attendee who has a
rubella infection in pregnancy following: detection of immunoglobulin M antibody OR positive immunoglobulin G antibodies OR a specimen that is for rubella virus following: cataracts, glaucoma, congenital heart disease, hearing impairment, pigmentary retinopathy, purpura, hepatosplenomegaly, jaundice, microcephaly, developmental delay, meningoencephalitis, radioluscent bone disease least two of the following without a more plausible etiology: -cataracts or congenital glaucoma, -congenital heart disease -hearing impairment, -pigmentary retinopathy; 2)An infant with no laboratory confirmation of rubella infection but at least one of the following without a more plausible etiology; -cataracts or congenital glaucoma, -congenital heart disease -hearing impairment, -pigmentary retinopathy; AND one or more of the following: -purpura, -hepatosplenomegaly, -jaundice, -microcephaly, -developmental delay, -meningoencephalitis, -radiolucent bone disease. immunoglobulin M antibody OR positive rubella-specific immunoglobulin G antibodies whose titre does not drop by at least two fold within a 4 week period OR a specimen that is for rubella virus Congenital syphilis A condition affecting an infant or child (< 2 years) whose mother had untreated or inadequately treated syphilis. Early Congenital Syphilis: may present anytime in infancy or early childhood (< 2 years). Infant or child < 2 years who has a REACTIVE non-treponemal test on serum/ blood (RPR POSITIVE) ? Ante-natal clinic attendee who has a Infant or child < 2 years whose mother had untreated or *inadequately treated syphilis at delivery,regardless of signs in infant OR Probable case with confirmatory laboratory tests on placenta/ amniotic fluid/ autopsy material/ exudates from suspicious lesions/ body fluids e.g. nasal discharge, CSF motile treponemes seen on darkfield microscopy specific
Appendix_C_NMC_case_definitions.docx