response is achieved. Continue assessing the patient and review after the 10mg bolus dose. A challenge is positive if one or more of the following results are achieved: An improvement in UPDRS score of 20% of baseline score More than 25% improvement in walking time Alleviation of specific symptoms, e.g. pain, dystonia, non-motor presentations such as urinary retention, gastric disturbances, anxiety. Successful Apomorphine therapy in the community is achieved with effective shared care between primary, secondary and or tertiary centres. Patients, families and healthcare professionals must have access to specialist support. A full range of educational materials, videos, DVDs and training is available free of charge. Intermittent subcutaneous injections are used to reverse disabling periods in ‘OFF’ conjunction with oral therapy. These are suitable for patients who experience unpredictable periods. symptoms can include pain, marked dystonia, freezing and immobility, ‘OFF’ ‘OFF’ swallowing and speech problems. Some patients experience a range of non-motor symptoms including depression, gastric and elimination problems. An individual therapeutic dose is established for each patient. A 10 year review of 161 patients at the Middlesex Hospital showed that once the correct dose has been established it changes very little (Hughes, 1995).
response is achieved. Continue assessing the patient and review after the 10mg bolus dose. A challenge is positive if one or more of the following results are achieved: An improvement in UPDRS score of 20% of baseline score More than 25% improvement in walking time Alleviation of specific symptoms, e.g. pain, dystonia, non-motor presentations such as urinary retention, gastric disturbances, anxiety. Successful Apomorphine therapy in the community is achieved with effective shared care between primary, secondary and or tertiary centres. Patients, families and healthcare professionals must have access to specialist support. A full range of educational materials, videos, DVDs and training is available free of charge. Intermittent subcutaneous injections are used to reverse disabling ‘OFF’ periods in conjunction with oral therapy. These are suitable for patients who experience unpredictable ‘OFF’ periods. ‘OFF’ symptoms can include pain, marked dystonia, freezing and immobility, swallowing and speech problems. Some patients experience a range of non-motor symptoms including depression, gastric and elimination problems. An individual therapeutic dose is established for each patient. A 10 year review of 161 patients at the Middlesex Hospital showed that once the correct dose has been established it changes very little (Hughes, 1995).
apo-Best-Practice-Guidelines-2013-draft.docx