19: Effects of single dose aprepitant on AUC of CYP3A4 substrates Fold increase in AUC Day 1 Day 2 Day 3 Day 4 Day 8 Aprepitant single Study Substrate dose (Day 1) Dexamethasone 8 mg Days 1, 2, 3 1.96 2.29 1.61 - - 250 mg fasted P155 Dexamethasone 12 mg Day 1, 2.09 2.33 1.42 1.06 - 200 mg fed* P175 8 mg Days 2, 3, 4 Midazolam 2 mg Day 1 1.63 - - - 0.69 250 mg fasted P155 Midazolam 2 mg Days 1, 4, 8 3.15 - - 1.24 0.65 200 mg fed* P175 * standard light breakfast
19: Effects of single dose aprepitant on AUC of CYP3A4 substrates Fold increase in AUC Substrate Day 1 Day 2 Day 3 Day 4 Day 8 Aprepitant single dose (Day 1) Study Dexamethasone 8 mg Days 1, 2, 3 1.96 2.29 1.61 - - 250 mg fasted P155 Dexamethasone 12 mg Day 1, 8 mg Days 2, 3, 4 2.09 2.33 1.42 1.06 - 200 mg fed* P175 Midazolam 2 mg Day 1 1.63 - - - 0.69 250 mg fasted P155 Midazolam 2 mg Days 1, 4, 8 3.15 - - 1.24 0.65 200 mg fed* P175 * standard light breakfast
auspar-aprepitant-121112.docx