Bornehag, 2015: MHiNP, Swan, 2015: MECPP, MEP, MBzP, MnBP, MiBP, MCPP, MOiNP, MCOP, (MU) ∑DiNP MCNP, MCOP (MU); MEHP, MEHHP, MEOHP, ∑DEHP Swan, 2015: MEHP, MEHHP, (MU, girls) MEOHP, ( MU, boys) ∑DEHP Swan, 2008: MEHP, MEHHP Cryptorchidism - Swan, 2008: MEP, MnBP, MMP, MEOHP (MU, boys) (MU, boys) Lin, 2011: (MU, girls) - Lin, 2011: MMP, MEP, MBP, MBzP, MEHP, MEHHP, ∑DEHP Anti-androgenic Araki, 2014: MEHP (maternal MEOHP (MU); (MU, boys) ∑DEHP blood, boys) Araki, 2014: MEHP (maternal blood, girls) Comments: exposure to phthalates and hypospadias and CHD: not yet investigated by nested prospective cohort studies. In Abbreviations: AF, amniotic fluid; AGD, anogenital distance; AGI, anogenital index; BW, birth weight; CB, cord blood; CHD, congenital heart defect; HMW-phthalates, high-molecular-weight phthalates; JEM, job-exposure matrix; BW, birth weight; LMW-phthalates, weight phthalates; MU, maternal urine; summed DEHP metabolites (MEHP, MEHHP, MEOHP, MECPP); summed DiNP ∑DEHP, ∑DiNP, metabolites (MHiNP, MOiNP, MCOP). a all: DEHP, DEP, DMP, DiBP, DnBP, DMEP, BMPP, DEEP, DNHP, BBP, DBEP, DCHP, DNOP, DNP. b maternal exposure defined as occupational exposure and/or newly decorated house. Supplementary 2 Biological matrices used in studies with unfavorable outcomes [First author, year: outcomes (involved metabolites, sex if differences)]. Type of Cross-sectional Case-control Prospective cohort study Risk Increased risk Decreased Increased Decreased Increased Decreased
Bornehag, 2015: MHiNP, MOiNP, MCOP, ∑DiNP (MU) Swan, 2015: MEHP, MEHHP, MEOHP, ∑DEHP ( MU, boys) Swan, 2015: MECPP, MEP, MBzP, MnBP, MiBP, MCPP, MCNP, MCOP (MU); MEHP, MEHHP, MEOHP, ∑DEHP (MU, girls) Cryptorchidism Swan, 2008: MEHP, MEHHP (MU, boys) - Swan, 2008: MEP, MnBP, MMP, MEOHP (MU, boys) Anti-androgenic Lin, 2011: ∑DEHP (MU, girls) Araki, 2014: MEHP (maternal blood, boys) - Lin, 2011: MMP, MEP, MBP, MBzP, MEHP, MEHHP, MEOHP (MU); ∑DEHP (MU, boys) Araki, 2014: MEHP (maternal blood, girls) Comments: In exposure to phthalates and hypospadias and CHD: not yet investigated by nested prospective cohort studies. Abbreviations: AF, amniotic fluid; AGD, anogenital distance; AGI, anogenital index; BW, birth weight; CB, cord blood; CHD, congenital heart defect; HMW-phthalates, high-molecular-weight phthalates; JEM, job-exposure matrix; BW, birth weight; LMW-phthalates, phthalates; MU, maternal urine; ∑DEHP, summed DEHP metabolites (MEHP, MEHHP, MEOHP, MECPP); ∑DiNP, summed DiNP metabolites (MHiNP, MOiNP, MCOP). a all: DEHP, DEP, DMP, DiBP, DnBP, DMEP, BMPP, DEEP, DNHP, BBP, DBEP, DCHP, DNOP, DNP. b maternal exposure defined as occupational exposure and/or newly decorated house. Supplementary 2 Biological matrices used in studies with unfavorable outcomes [First author, year: outcomes (involved metabolites, sex if differences)]. Type of study Cross-sectional Case-control Prospective cohort Risk Increased risk Decreased Increased Decreased Increased Decreased weight
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