Vascular 1 (age, sex, Model 2 (Model 1 + P-value for endpoint smoking, systolic 18 principal difference blood pressure, body components between mass index, type 2 explaining 95% Models 2 and 1 diabetes and total variance of 225 metabolic markers) Myocardial 0.800 (0.782, 0.819) 0.813 (0.795, 0.832) 7.30x10-5 infarction Ischemic 0.767 (0.748, 0.786) 0.775 (0.757, 0.794) 9.09x10-3 stroke Intracerebral 0.797 (0.778, 0.815) 0.809 (0.791, 0.827) 2.98x10-4 hemorrhage
Vascular endpoint 1 (age, sex, smoking, systolic blood pressure, body mass index, type 2 diabetes and total Model 2 (Model 1 + 18 principal components explaining 95% variance of 225 metabolic markers) P-value for difference between Models 2 and 1 Myocardial infarction 0.800 (0.782, 0.819) 0.813 (0.795, 0.832) 7.30x10-5 Ischemic stroke 0.767 (0.748, 0.786) 0.775 (0.757, 0.794) 9.09x10-3 Intracerebral hemorrhage 0.797 (0.778, 0.815) 0.809 (0.791, 0.827) 2.98x10-4
1-s2.0-S0735109717418687-mmc1.docx