Supplementary 3: application of the GRACE checklist score (Dreyer et al., 2014) to estimate the quality of included observational studies. Study AmpliChip AmpliChip CNSDose GeneSight Genecept Genelex HILOmet Neuropharmagen Pillcheck (Hodgson et al., (Hodgson et al., (Bousman et al., (Winner et al., (Brennan et al., (Verbeurgt et al., (Ruaño et al., (Espadaler et al., (Papastergiou et 2014) 2015) 2017) 2013a) 2015) 2014) 2013) 2017) al., 2017) Scale item D1. Treatment Yes Yes Yes No No No Yes No No details D2. Suff. Yes Yes Yes Yes Yes Yes Yes Yes Yes Details on primary outcomes D3. Objective Yes Yes Yes Yes Yes Yes Yes Yes Yes measure of primary Outcome D4. Validated Yes Yes Yes Yes Yes Yes Yes Yes Yes primary outcomes D5. Primary Yes Yes Yes Yes Yes Yes Yes Yes Yes outcome measured in the same way in all subjects D6. Inclusion Yes Yes No No No No Yes Yes No of important covariates M1. Drug No No Yes No No No No No No Naive or washout? M2. Yes Yes Yes Yes Yes Yes Yes Yes Yes Concurrent comparator groups? M3. Were Yes Yes No No No No No No No confounding factors considered? M4. Free of No No No Yes No Yes Yes No Yes Immortal time bias? M5. Recursive No Yes No Yes Yes No No No No analysis?
Supplementary 3: application of the GRACE checklist score (Dreyer et al., 2014) to estimate the quality of included observational studies. Study Scale item AmpliChip (Hodgson et al., 2014) AmpliChip (Hodgson et al., 2015) CNSDose (Bousman et al., 2017) GeneSight (Winner et al., 2013a) Genecept (Brennan et al., 2015) Genelex (Verbeurgt et al., 2014) HILOmet (Ruaño et al., 2013) Neuropharmagen (Espadaler et al., 2017) Pillcheck (Papastergiou et al., 2017) D1. Treatment details Yes Yes Yes No No No Yes No No D2. Suff. Details on primary outcomes Yes Yes Yes Yes Yes Yes Yes Yes Yes D3. Objective measure of primary Outcome Yes Yes Yes Yes Yes Yes Yes Yes Yes D4. Validated primary outcomes Yes Yes Yes Yes Yes Yes Yes Yes Yes D5. Primary outcome measured in the same way in all subjects Yes Yes Yes Yes Yes Yes Yes Yes Yes D6. Inclusion of important covariates Yes Yes No No No No Yes Yes No M1. Drug Naive or washout? No No Yes No No No No No No M2. Concurrent comparator groups? Yes Yes Yes Yes Yes Yes Yes Yes Yes M3. Were confounding factors considered? Yes Yes No No No No No No No M4. Free of Immortal time bias? No No No Yes No Yes Yes No Yes M5. Recursive analysis? No Yes No Yes Yes No No No No
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