cholestasis Nervous system disorders Very common headache peripheral neuropathy, headache, Common peripheral neuropathy, dizziness dizziness Guillain-Barré syndrome, Polyneuropathy, autoimmune polyneuropathy, neuritis, peroneal nerve Uncommon neuropathy (including facial and palsy, autoimmune neuropathy abducens paresis) (including facial and abducens nerve paresis), encephalitisb Guillain-Barré syndrome, Rare demyelination, myasthenic syndrome Eye disorders Common dry eye uveitis, blurred vision Uncommon Uveitis, blurred vision Cardiac disorders Common tachycardia arrhythmia (including ventricular Uncommon tachycardia arrhythmia)a, atrial fibrillation, myocarditisa,e arrhythmia (including ventricular Rare arrhythmia), myocarditis a,e, atrial fibrillation Vascular disorders Common hypertension hypertension Uncommon vasculitis Respiratory, thoracic and mediastinal disorders Common pneumonitisa,c, dyspnoea, cough pneumonitisa,c dyspnoea, cough Uncommon pleural effusion pleural effusion Rare lung infiltration Gastrointestinal disorders colitis, diarrhoea, vomiting, nausea, Very common diarrhoea, nausea abdominal pain colitis, stomatitis, vomiting, abdominal stomatitis, gastritis, constipation, dry Common pain, constipation, dry mouth mouth pancreatitis, intestinal perforation, Uncommon Pancreatitis, gastritis duodenitis Rare duodenal ulcer Skin and subcutaneous tissue disorders Very common pruritus rashd, pruritus vitiligo, dry skin, erythema, alopecia, Common vitiligo, dry skin, erythema, alopecia urticaria erythema multiforme, psoriasis, rosacea, Uncommon psoriasis urticaria
cholestasis Nervous system disorders Very common headache Common peripheral neuropathy, headache, dizziness peripheral neuropathy, dizziness Uncommon Polyneuropathy, autoimmune neuropathy (including facial and abducens paresis) Guillain-Barré syndrome, polyneuropathy, neuritis, peroneal nerve palsy, autoimmune neuropathy (including facial and abducens nerve paresis), encephalitisb Rare Guillain-Barré syndrome, demyelination, myasthenic syndrome Eye disorders Common dry eye uveitis, blurred vision Uncommon Uveitis, blurred vision Cardiac disorders Common tachycardia Uncommon tachycardia arrhythmia (including ventricular arrhythmia)a, atrial fibrillation, myocarditisa,e Rare arrhythmia (including ventricular arrhythmia), myocarditis a,e, atrial fibrillation Vascular disorders Common hypertension hypertension Uncommon vasculitis Respiratory, thoracic and mediastinal disorders Common pneumonitisa,c, dyspnoea, cough pneumonitisa,c dyspnoea, cough Uncommon pleural effusion pleural effusion Rare lung infiltration Gastrointestinal disorders Very common diarrhoea, nausea colitis, diarrhoea, vomiting, nausea, abdominal pain Common colitis, stomatitis, vomiting, abdominal pain, constipation, dry mouth stomatitis, gastritis, constipation, dry mouth Uncommon Pancreatitis, gastritis pancreatitis, intestinal perforation, duodenitis Rare duodenal ulcer Skin and subcutaneous tissue disorders Very common pruritus rashd, pruritus Common vitiligo, dry skin, erythema, alopecia vitiligo, dry skin, erythema, alopecia, urticaria Uncommon erythema multiforme, psoriasis, rosacea, urticaria psoriasis
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