significantly associated with asbestosis mortality. Modelled exposure-response relationship showed no threshold for development of asbestosis. Ehrlich et al RMA ID: Long Term Subset of 386 Amosite 5 -120 Fibre Duration of Radiological study Asbestos (1992) 034901 Radiological factory workers asbestos (>5µm long) concentration exposure: reporting effect of exposure Effects of (100% men) factory method used: Median=0.5;6 short term amosite producing Short Term with less than Membrane months exposure producing parenchymal Cumulative Exposure to one year of Filter Method parenchymal and abnormality (Imported exposure: Amosite exposure and (1968 and years pleural seen at <5 from South n=386; Asbestos low cumulative 1971). abnormalities. fibre/mL-years Africa; very Median=25.1 Among exposure (<25 Average fibre Parenchymal small (range=0.1 Factory fibre/mL-year) counts for abnormality (profusion amounts of Workers 238 had serial each job title >1/0 ) >20 years from chrysotile X-rays were first employment by used at one Exposure estimated from cumulative exposure time) concentration: measurements (fibre/mL-year): Smoking history M=51.8 carried out at <5 fibre/mL-year: available (SD=25) Also two other n=85,10(12%)= fibre/mL residential plants abnormal exposure operated by 5.1-25 the company 12(14%)= n=87, after 1954; abnormal one in Tyler, 25.1-125 Texas and year: n=119, 30(25%)= another in Port abnormal Allegheny, >125 Pennsylvania. n=49,29(59%)= abnormal
significantly associated with asbestosis mortality. Modelled exposure-response relationship showed no threshold for development of asbestosis. Ehrlich et al (1992) RMA ID: 034901 Long Term Radiological Effects of Short Term Exposure to Amosite Asbestos Among Factory Workers Subset of 386 factory workers (100% men) with less than one year of exposure and low cumulative exposure (<25 fibre/mL-year) 238 had serial X-rays Smoking history available Amosite asbestos factory (Imported from South Africa; very small amounts of chrysotile used at one time) Also residential exposure 5 -120 (>5µm long) Cumulative exposure: n=386; Median=25.1 (range=0.1 Exposure concentration: M=51.8 (SD=25) fibre/mL Fibre concentration method used: Membrane Filter Method (1968 and 1971). Average fibre counts for each job title were estimated from measurements carried out at two other plants operated by the company after 1954; one in Tyler, Texas and another in Port Allegheny, Pennsylvania. Duration of exposure: Median=0.5;6 months years Radiological study reporting effect of short term amosite exposure producing parenchymal and pleural abnormalities. Parenchymal abnormality (profusion >1/0 ) >20 years from first employment by cumulative exposure (fibre/mL-year): <5 fibre/mL-year: n=85,10(12%)= abnormal 5.1-25 n=87, 12(14%)= abnormal 25.1-125 n=119, 30(25%)= abnormal >125 n=49,29(59%)= abnormal Asbestos exposure producing parenchymal abnormality seen at <5 fibre/mL-years year:
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