5 2 ng/ml (n = 40) ≥400 7 9 <400 ng/ml (n = 101) <0.001 0.352 Differentiation 0 0 Well (n = 27) 4 10 Moderately (n = 109) 12 2 Poorly (n = 26) 0.001 0.352 vp/im 15 9 + (n = 92) 1 3 (n = 70) – NA NA Etiology 0 0 Alcoholic (n = 5) 9 4 HBV (n = 42) 6 6 HCV (n = 69) 0 0 NASH (n = 6) 1 2 Others (n = 40) 0.528 0.252 METAVIR score 8 5 0–2 (n = 93) 8 7 3–4 (n = 69) a 0.602 <0.001 Ki67 index 11 0 (n = 14) ≥30% 5 12 <30% (n = 148) <0.001 1.000 Mitotic counts 5 0 HPF (n = 5) ≥10/10 11 12 <10/10 HPF (n = 157) Pearson’s chi-squared test and a Fisher’s exact test. NA, not assessed. Supplementary Table 4. Association of clinicopathological features with p53-only-positive cases and all-negative cases the in group. –/– All-negative cases p53-only-positive cases n p value n p value a <0.001 0.354 AFP 3 2 ng/ml (n = 21) ≥400 78 7 <400 ng/ml (n = 133) a 0.456 0.273 PIVKA-II 21 4 ng/ml (n = 40) ≥400 45 5 <400 ng/ml (n = 101) a <0.001 0.401 Differentiation 25 0 Well (n = 27) 57 7 Moderately (n = 109) 5 2 Poorly (n = 26) a <0.001 0.733 vp/im 38 6 + (n = 92) 49 3 (n = 70) – NA NA Etiology 2 0 Alcoholic (n = 5) 18 4 HBV (n = 42) 34 3 HCV (n = 69) 4 1 NASH (n = 6)
≥400 ng/ml (n = 40) 5 2 <400 ng/ml (n = 101) 7 9 Differentiation <0.001 0.352 Well (n = 27) 0 0 Moderately (n = 109) 4 10 Poorly (n = 26) 12 2 vp/im 0.001 0.352 + (n = 92) 15 9 – (n = 70) 1 3 Etiology NA NA Alcoholic (n = 5) 0 0 HBV (n = 42) 9 4 HCV (n = 69) 6 6 NASH (n = 6) 0 0 Others (n = 40) 1 2 METAVIR score 0.528 0.252 0–2 (n = 93) 8 5 3–4 (n = 69) 8 7 Ki67 index <0.001 a 0.602 ≥30% (n = 14) 11 0 <30% (n = 148) 5 12 Mitotic counts <0.001 1.000 ≥10/10 HPF (n = 5) 5 0 <10/10 HPF (n = 157) 11 12 Pearson’s chi-squared test and a Fisher’s exact test. NA, not assessed. Supplementary Table 4. Association of clinicopathological features with p53-only-positive cases and all-negative cases the in –/– group. All-negative cases p53-only-positive cases n p value n p value AFP <0.001 0.354 a ≥400 ng/ml (n = 21) 3 2 <400 ng/ml (n = 133) 78 7 PIVKA-II 0.456 0.273 a ≥400 ng/ml (n = 40) 21 4 <400 ng/ml (n = 101) 45 5 Differentiation <0.001 0.401 a Well (n = 27) 25 0 Moderately (n = 109) 57 7 Poorly (n = 26) 5 2 vp/im <0.001 0.733 a + (n = 92) 38 6 – (n = 70) 49 3 Etiology NA NA Alcoholic (n = 5) 2 0 HBV (n = 42) 18 4 HCV (n = 69) 34 3 NASH (n = 6) 4 1
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