At least one TEAE leading to 7 (21.2) 7 (21.9) 7 (46.7) permanent treatment discontinuation At least one related TEAE leading 2 (6.1) 3 (9.4) 4 (26.7) to permanent treatment discontinuation Abbreviations: DLT, dose-limiting toxicity; TEAE, treatment-emergent adverse event. S4. Most commonly occurring (> 10%) TEAEs (safety analysis set; all grades) TEAEs occurring in 10% of patients Regimen 1 Regimen 2 Regimen 3 ≥ in any regimen (all grades) (N = 33) (N = 32) (N = 15) 33 (100) 32 (100) 15 (100) Patients with at least one event, n (%) Diarrhoea 15 (45.5) 17 (53.1) 10 (66.7)
At least one TEAE leading to permanent treatment discontinuation 7 (21.2) 7 (21.9) 7 (46.7) At least one related TEAE leading to permanent treatment discontinuation 2 (6.1) 3 (9.4) 4 (26.7) Abbreviations: DLT, dose-limiting toxicity; TEAE, treatment-emergent adverse event. S4. Most commonly occurring (> 10%) TEAEs (safety analysis set; all grades) TEAEs occurring in ≥ 10% of patients in any regimen (all grades) Regimen 1 (N = 33) Regimen 2 (N = 32) Regimen 3 (N = 15) Patients with at least one event, n (%) 33 (100) 32 (100) 15 (100) Diarrhoea 15 (45.5) 17 (53.1) 10 (66.7)
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