552.7 ± 3.3 0.23 ± 0.03 -38.9 ± 2.2 (pH 5.5 24h) BZL-pLNPs 303.5 ± 2.0 0.19 ± 0.03 -45.2 ± 1.6 (pH 7.4 after 4h) BZL-pLNPs 372.2 ± 10.8 0.29 ± 0.03 -44.7 ± 1.2 (pH 7.4 after 24h) SFN-pLNPs 330.5 ± 2.8 0.16 ± 0.03 -48.2 ± 4.2 (pH 5.5 after 4h) SFN-pLNPs 674.7 ± 37.1 0.35 ± 0.04 -41.5 ± 1.0 (pH 5.5 after 24h) SFN-pLNPs 315.3 ± 4.3 0.17 ± 0.01 -49.8 ± 5.0 (pH 7.4 after 4h) SFN-pLNPs 398.9 ± 6.4 0.32 ± 0.02 -47.0 ± 2.6 (pH 7.4 after 24h) IC50 values of BZL determined for the different cell lines. Table S6. Cell line IC50 (µM) MDA-MB-231 8.3 MCF-7 9.7 PC3-MM2 12.4 Caco-2 0.6 4.6 EA.hy926 Video S1. Fe3O4-LNPs attracted towards the point where the magnetic field is higher and translocated to another place of the well after moving the magnet. (See the provided Video File for details).
(pH 5.5 24h) 552.7 ± 3.3 0.23 ± 0.03 -38.9 ± 2.2 BZL-pLNPs (pH 7.4 after 4h) 303.5 ± 2.0 0.19 ± 0.03 -45.2 ± 1.6 BZL-pLNPs (pH 7.4 after 24h) 372.2 ± 10.8 0.29 ± 0.03 -44.7 ± 1.2 SFN-pLNPs (pH 5.5 after 4h) 330.5 ± 2.8 0.16 ± 0.03 -48.2 ± 4.2 SFN-pLNPs (pH 5.5 after 24h) 674.7 ± 37.1 0.35 ± 0.04 -41.5 ± 1.0 SFN-pLNPs (pH 7.4 after 4h) 315.3 ± 4.3 0.17 ± 0.01 -49.8 ± 5.0 SFN-pLNPs (pH 7.4 after 24h) 398.9 ± 6.4 0.32 ± 0.02 -47.0 ± 2.6 Table S6. IC50 values of BZL determined for the different cell lines. Cell line IC50 (µM) MDA-MB-231 8.3 MCF-7 9.7 PC3-MM2 12.4 Caco-2 0.6 EA.hy926 4.6 Video S1. Fe3O4-LNPs attracted towards the point where the magnetic field is higher and translocated to another place of the well after moving the magnet. (See the provided Video File for details).
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