and (HE-CAM test = Hen's Egg (; ) In vivo in vitro Membrane) studies with other types of Rel 2; HE-CAM test, No TG, MWCNT (long and short) suggest slight irritation (WoE) (reversible conjunctival redness and discharge) not warranting classification or no irritating effect. (; ) In an in vivo study another type of MWCNT Rel 1; OECD TG 405 (Graphistrength) showed irritating effects (chemosis, redness, iris lesions, corneal opacity) were observed. These were interpreted as secondary to abrasive (mechanical) action as no corneal opacification observed in BCOP (Bovine Corneal Opacity and Permeability) test. Dermal Irritation VERY LOW: MWCNT is not irritating to skin Dermal Irritation No irritating or corrosive properties in dermal irritation 3 study reports (2006) Rel 1; OECD TG 404 (corrosion) test in vivo and reconstructed human skin (in () Rel 1; OECD TG 431 vitro). No significant increase of IL-1alpha (marker of irritation) in human reconstructed epidermis in vitro (; ) Rel 2;
In vivo and in vitro (HE-CAM test = Hen's Egg Membrane) studies with other types of MWCNT (long and short) suggest slight irritation (reversible conjunctival redness and discharge) not warranting classification or no irritating effect. In an in vivo study another type of MWCNT (Graphistrength) showed irritating effects (chemosis, redness, iris lesions, corneal opacity) were observed. These were interpreted as secondary to abrasive (mechanical) action as no corneal opacification observed in BCOP (Bovine Corneal Opacity and Permeability) test. (; ) (; ) Rel 2; HE-CAM test, No TG, (WoE) Rel 1; OECD TG 405 Dermal Irritation VERY LOW: MWCNT is not irritating to skin Dermal Irritation No irritating or corrosive properties in dermal irritation (corrosion) test in vivo and reconstructed human skin (in vitro). No significant increase of IL-1alpha (marker of irritation) in human reconstructed epidermis in vitro 3 study reports (2006) () (; ) Rel 1; OECD TG 404 Rel 1; OECD TG 431 Rel 2;
1-s2.0-S0160412016306043-mmc1.docx