NAWM WM p-values GM GM p-values patients controls patients controls mean (SD) mean (SD) patients mean (SD) mean (SD) patients MTR MTR vs MTR MTR vs controls controls Motor pair 36.2 (1.4) 37.2 (0.59) p=0.002 35.1 (2.4) 35.7 (1.2) p=0.392 Left 36.1 (1.3) 37.0 (0.66) p=0.006 33.9 (2.5) 35.3 (1.8) p=0.235 Right Callosal pair 38.1 (1.7) 39.5 (0.46) p<0.001 32.4 (1.3) 33.6 (0.97) p=0.004 Optic pair 34.1 (2.0) 35.5 (1.4) p=0.080b 31.2 (1.7) 32.6 (1.4) p=0.011a,b Left 34.4 (1.9) 36.1 (0.85) p=0.002 32.2 (1.4) 33.6 (0.94) p=0.001 Right aThis comparison lost significance when an influential datapoint was omitted. bUnder a Bonferroni correction, multiplying all p-values by the number of tests, these two p-values are no longer significant at the 5% error rate. Table 2. Mean MTR values at baseline in GM and WM regions in patients and healthy controls, with p-values of the comparison between the two groups adjusting for age and gender. Table 3 A.
NAWM patients mean (SD) MTR WM controls mean (SD) MTR p-values patients vs controls GM patients mean (SD) MTR GM controls mean (SD) MTR p-values patients vs controls Motor pair Left Right 36.2 (1.4) 36.1 (1.3) 37.2 (0.59) 37.0 (0.66) p=0.002 p=0.006 35.1 (2.4) 33.9 (2.5) 35.7 (1.2) 35.3 (1.8) p=0.392 p=0.235 Callosal pair 38.1 (1.7) 39.5 (0.46) p<0.001 32.4 (1.3) 33.6 (0.97) p=0.004 Optic pair Left Right 34.1 (2.0) 34.4 (1.9) 35.5 (1.4) 36.1 (0.85) p=0.080b p=0.002 31.2 (1.7) 32.2 (1.4) 32.6 (1.4) 33.6 (0.94) p=0.011a,b p=0.001 aThis comparison lost significance when an influential datapoint was omitted. bUnder a Bonferroni correction, multiplying all p-values by the number of tests, these two p-values are no longer significant at the 5% error rate. Table 2. Mean MTR values at baseline in GM and WM regions in patients and healthy controls, with p-values of the comparison between the two groups adjusting for age and gender. Table 3 A.
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