2 y from risk of CRC. Data suggests diagnosis. that those who do not Nutrition use aspirin, NSAID’s or Coordinating HRT may be more Centre food affected by TFA database Outcome Dx: primary colon cancer-medical records () Total TFA Country: Scotland Dietary Family hx CRC, vs quartile of Intake: +ve assoc. TFA ↑ ↓ SOCCS assessment: TEI, TFI, alcohol, TFA intake and risk of intake & CRC in women TFA intake N=2910, 64.3% M SFFQ 150 items non-steroidal CRC only Case-Control &CRC 1455 validated in Trans MUFA: Not signif in men Matched 1455 younger people drugs, *OR 1.38 (1.09, 1.74) Age: 64.3 (16-79 y) FA data from UK smoking, BMI, Significant results only food comp tables PAL, total FA in females: TFA intake (g/day) and FOODBASE intake. *OR 1.57 (1.05,2.36) 3.55 database. CRC risk 57% higher in Outcome dx: CRC women in 4th vs 1st presented to quintile of intake. surgical unit in Scotland () Total TFA Country: US Dietary Age, sex, Energy adj TFA Intake: No assoc. TFA & Investigate assessment: calcium intake, consumption was not CRC assoc. TFA & N=1643, 50.7% M Modified version meat associated with CRC. Case-Control CRC race Age: 64.7 (40-80)y of 100 item SFFQ consumption, No found between differences Cases: 623 block food alcohol, BMI, vs quintile of consumption TFA & ↑ ↓ ↑ Controls: 1020 frequency- 29 family Hx CRC intake: specific tumour location local foods added Whites: Adj. OR 1.01 (proximal or distal colon) TFA intake (mean Interviews by (95% CI 0.69, 1.49) g/day, SD) trained nurses. AA: Adj. OR 0.99 (0.61, 5.47 ±2.65 1.62) Outcome Dx:
2 y from diagnosis. Nutrition Coordinating Centre food database Outcome Dx: primary colon cancer-medical records risk of CRC. Data suggests that those who do not use aspirin, NSAID’s or HRT may be more affected by TFA () Case-Control Total TFA TFA intake &CRC Country: Scotland SOCCS N=2910, 64.3% M 1455 Matched 1455 Age: 64.3 (16-79 y) TFA intake (g/day) 3.55 Dietary assessment: SFFQ 150 items validated in younger people FA data from UK food comp tables and FOODBASE database. Outcome dx: CRC presented to surgical unit in Scotland Family hx CRC, TEI, TFI, alcohol, non-steroidal drugs, smoking, BMI, PAL, total FA intake. ↑ vs ↓ quartile of TFA intake and risk of CRC Trans MUFA: *OR 1.38 (1.09, 1.74) Significant results only in females: *OR 1.57 (1.05,2.36) CRC risk 57% higher in women in 4th vs 1st quintile of intake. Intake: +ve assoc. TFA intake & CRC in women only Not signif in men () Case-Control Total TFA Investigate assoc. TFA & CRC race differences Country: US N=1643, 50.7% M Age: 64.7 (40-80)y Cases: 623 Controls: 1020 TFA intake (mean g/day, SD) 5.47 ±2.65 Dietary assessment: Modified version of 100 item SFFQ block food frequency- 29 local foods added Interviews by trained nurses. Outcome Dx: Age, sex, calcium intake, meat consumption, alcohol, BMI, family Hx CRC Energy adj TFA consumption was not associated with CRC. ↑ vs ↓ quintile of intake: Whites: Adj. OR 1.01 (95% CI 0.69, 1.49) AA: Adj. OR 0.99 (0.61, 1.62) Intake: No assoc. TFA & CRC No found between ↑ consumption TFA & specific tumour location (proximal or distal colon)
Appendix%201%20%20for%20Narrative%20Review.docx