Maternal N=1369 mother-child Self-administered smoking status, (95% CI β=0.02; TFA intake pairs validated SFFQ age during Age: 32.4y during 1st & 2nd BMI, 2nd trimester +ve pregnancy FU 1st & 2nd trimester trimesters. PA, television assoc. and foetal viewing, fish *β=0.29; (95% CI growth TFA intake (g/day): Outcome dx: consumption 0.07,0.51) 2.35 ± 1.07 Data on infant birth wt from medical records. Length of gestation by subtracting date of last menstrual period from day of delivery. BW/GA z value (foetal growth) using US ref data () 18-1t isomer Country: Netherlands Serum TFA: Maternal age, None of the assoc. b/t Serum: No assoc (elaidic acid) MEFAB Maternal serum Ht, BMI, parity, relative maternal between neonatal birth Prospective N=782 mother-infant samples collected smoking & 18:1t contents and dimensions and maternal Associations pairs at 16, 22, 32 drinking during BW, BL or HC reached plasma fatty acid b/t neonatal 29y weeks & delivery. pregnancy, statistical significance Age: contents birth socioeconomic or showed a trend. dimensions Serum TFA: (% w/w) Outcome dx: status, GA, Backward regression Considerable number of and maternal as median (25th-75th Local hospital infant sex analysis demonstrated 18:1t values missing from plasma fatty percentile) staff members that for none of the database, acid contents maternal plasma PL: recorded BW, BL 12 birth outcome FA 16 w: 0.45 (0.33-0.59) & HC on combinations 18:1t 22 w: 0.44 (0.32-0.58) standardised data was neither a 32w: 0.42 (0.31-0.54) sheets predictor or Delivery: 0.37 (0.27- confounder. 0.49) Results not published () Total TFA Country: The Validated SFFQ Age, sex, Rate ratios of Intake: no between Netherlands Food composition education, total dementia per TTFA and dementia risk
Maternal TFA intake during pregnancy and foetal growth N=1369 mother-child pairs Age: 32.4y FU 1st & 2nd trimester TFA intake (g/day): 2.35 ± 1.07 Self-administered validated SFFQ during 1st & 2nd trimesters. Outcome dx: Data on infant birth wt from medical records. Length of gestation by subtracting date of last menstrual period from day of delivery. BW/GA z value (foetal growth) using US ref data smoking status, age BMI, PA, television viewing, fish consumption β=0.02; (95% CI 2nd trimester +ve assoc. *β=0.29; (95% CI 0.07,0.51) () Prospective 18-1t isomer (elaidic acid) Associations b/t neonatal birth dimensions and maternal plasma fatty acid contents Country: Netherlands MEFAB N=782 mother-infant pairs Age: 29y Serum TFA: (% w/w) as median (25th-75th percentile) maternal plasma PL: 16 w: 0.45 (0.33-0.59) 22 w: 0.44 (0.32-0.58) 32w: 0.42 (0.31-0.54) Delivery: 0.37 (0.27- 0.49) Serum TFA: Maternal serum samples collected at 16, 22, 32 weeks & delivery. Outcome dx: Local hospital staff members recorded BW, BL & HC on standardised data sheets Maternal age, Ht, BMI, parity, smoking & drinking during pregnancy, socioeconomic status, GA, infant sex None of the assoc. b/t relative maternal 18:1t contents and BW, BL or HC reached statistical significance or showed a trend. Backward regression analysis demonstrated that for none of the 12 birth outcome FA combinations 18:1t was neither a predictor or confounder. Results not published Serum: No assoc between neonatal birth dimensions and maternal plasma fatty acid contents Considerable number of 18:1t values missing from database, () Total TFA Country: The Netherlands Validated SFFQ Food composition Age, sex, education, total Rate ratios of dementia per Intake: no between TTFA and dementia risk
Appendix%201%20to%20SD4%20Summary%20of%20reviewed%20literature%20examining%20TFA%20and%20health%20outcomes.docx