(n=1) 2012 Non blinded RTOG 30 Trolamine® Head and Grade 1-2 80% (12/15) + RCT single vs. standard of Neck treatment P<0.01 centre care group 46.6% (7/15) control group 20%(3/15) treatment Grade 3 53.4%(8/15) control group Watson et Non blinded CTCAE 198 Aluminium Breast Grade 3 4/99 + al 2012 RCT single based treatment centre antiperspirant and 3/99 FACT-B QoL vs. standard of control questionnaire care developed toxicity No statistical difference between intervention and control for QoL Haddad et Non RCT - RTOG 60 Aloe Vera Head and Grade 1-3 by treatment + al 2013 self-controlled. Neck, Pelvis, week 5 half Grade 1 (omitted controlled Half treatment Breast n=42 Q2, study field control, Grade 2 n=3 3,and 4 other half Grade 3 n=1 on RCT intervention SIGN ) Control half Grade1 n= 32
(n=1) 2012 Non blinded RCT single centre RTOG 30 Trolamine® vs. standard of care Head and Neck Grade 1-2 Grade 3 80% (12/15) treatment group 46.6% (7/15) control group 20%(3/15) treatment 53.4%(8/15) control group P<0.01 + Watson et al 2012 Non blinded RCT single centre CTCAE FACT-B QoL questionnaire 198 Aluminium based antiperspirant vs. standard of care Breast Grade 3 4/99 treatment and 3/99 control developed toxicity No statistical difference between intervention and control for QoL + Haddad et al 2013 Non RCT - study RTOG 60 Aloe Vera self-controlled. Half treatment field control, other half intervention Head and Neck, Pelvis, Breast Grade 1-3 by week 5 treatment half Grade 1 n=42 Grade 2 n=3 Grade 3 n=1 Control half Grade1 n= 32 + (omitted Q2, 3,and 4 on RCT SIGN ) controlled
appendix_5_-_summary_of_evidence.docx