Table S2 Model inputs for hospitalisation subgroup Adults and adolescents Children (patients 12 years) (patients 6-11 ≥ Value Variables (95% confidence Source Value Source interval) Baseline annual rate of exacerbations IA-05 EUP CSNS 0.8706 INNOVATE 2.1429 hospitalisation exacerbations (0.6308 to 1.2016) Hospitalisation () (3.5545 to 1.2918) () IA-05 EUP CSS 1.2235 INNOVATE 1.2857 hospitalisation exacerbations (0.9323 to 1.6057) hospitalisation () (0.6690 to 2.4711) () Treatment IA-05 EUP Proportion of 56.63% INNOVATE 54.05% (38.00% to hospitalisation responders (45.96% to 67.29%) hospitalisation () 70.11%) () Risk ratio for IA-05 EUP CSNS 0.5902 INNOVATE 0.2593 hospitalisation exacerbations (0.3137 to 1.1103) hospitalisation () (0.1006 to 0.6682) () (responders) Risk ratio for IA-05 EUP CSS 0.2907 INNOVATE 0.1440 hospitalisation exacerbations (0.1433 to 0.5900) hospitalisation () (0.0311 to 0.6666) () (responders) Mortality UK life-tables UK life-tables All-cause adjusted for ONS (); ONS (); adjusted for mortality asthma-related deterministic deterministic deaths. deaths.
Table S2 Model inputs for hospitalisation subgroup Adults and adolescents (patients ≥ 12 years) Children (patients 6-11 Variables Value (95% confidence interval) Source Value Source Baseline annual rate of exacerbations CSNS exacerbations 0.8706 (0.6308 to 1.2016) INNOVATE Hospitalisation () 2.1429 (3.5545 to 1.2918) IA-05 EUP hospitalisation () CSS exacerbations 1.2235 (0.9323 to 1.6057) INNOVATE hospitalisation () 1.2857 (0.6690 to 2.4711) IA-05 EUP hospitalisation () Treatment Proportion of responders 56.63% (45.96% to 67.29%) INNOVATE hospitalisation () 54.05% (38.00% to 70.11%) IA-05 EUP hospitalisation () Risk ratio for CSNS exacerbations (responders) 0.5902 (0.3137 to 1.1103) INNOVATE hospitalisation () 0.2593 (0.1006 to 0.6682) IA-05 EUP hospitalisation () Risk ratio for CSS exacerbations (responders) 0.2907 (0.1433 to 0.5900) INNOVATE hospitalisation () 0.1440 (0.0311 to 0.6666) IA-05 EUP hospitalisation () Mortality All-cause mortality UK life-tables adjusted for asthma-related deaths. ONS (); deterministic UK life-tables adjusted for deaths. ONS (); deterministic
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