potential for drug induced liver injury Gastrointestinal * perforation Hypertension - - Creatine kinase - - increase Weight increase - - Important Malignancy (excl *,^ potential NMSC) including risks lymphoma Cardiovascular risk *,^ - Interstitial lung - - disease Progressive *,^ - - multifocal Rhabdomyolysis - - - Epstein-Barr - events QT prolongation - - - Reduction in renal - function Modified Gastrointestinal - - release obstruction only Missing Effects on # pregnancy and the foetus Use in - - breastfeeding Effect on - vaccination efficacy and the use of live/attenuated vaccines
potential for drug induced liver injury Gastrointestinal perforation * Hypertension - - Creatine kinase increase - - Weight increase - - Important potential risks Malignancy (excl NMSC) including lymphoma *,^ Cardiovascular risk *,^ - Interstitial lung disease - - Progressive multifocal *,^ - - Rhabdomyolysis - - - Epstein-Barr events - QT prolongation - - - Reduction in renal function - Modified release only Gastrointestinal obstruction - - Missing Effects on pregnancy and the foetus # Use in breastfeeding - - Effect on vaccination efficacy and the use of live/attenuated vaccines -
auspar-tofacitinib-as-citrate-180525.docx