3.3.9.2 1 Write equations and outline Students draw structures and name January 2012 Aspirin Acylation. the mechanism of different acid anhydrides, acyl Unit 4 Q10a nucleophilic chlorides and amides. Draw the structure of and reactions of June 2006 Aspirin screen experiment (not a name acid anhydrides, acyl chlorides with water, Students write equations and Unit 4 Q1 suitable replacement for required acyl chlorides and alcohols, ammonia and mechanisms steps for a range of practical 10) amides. primary amines. addition-elimination reactions. June 2005 Unit 4 Q7 Know and understand Understand the Teacher demonstration: Reaction of the acylation reactions of advantages of using ethanoic anhydride with June 2003 water, alcohols, ethanoic anhydride rather ammonia, ethanol and Unit 5 Q8b ammonia and amines than ethanoyl chloride in phenylamine. with acyl chlorides and the production of aspirin. June 2010 acid anhydrides, Practical activity: Unit 4 Q7b and 7c including the mechanism The preparation of aspirin for acyl chlorides. Further physical Chemistry 1 (8
3.3.9.2 Acylation. Draw the structure of and name acid anhydrides, acyl chlorides and amides. Know and understand the acylation reactions of water, alcohols, ammonia and amines with acyl chlorides and acid anhydrides, including the mechanism for acyl chlorides. 1 Write equations and outline the mechanism of nucleophilic reactions of acyl chlorides with water, alcohols, ammonia and primary amines. Understand the advantages of using ethanoic anhydride rather than ethanoyl chloride in the production of aspirin. Students draw structures and name different acid anhydrides, acyl chlorides and amides. Students write equations and mechanisms steps for a range of addition-elimination reactions. Teacher demonstration: Reaction of ethanoic anhydride with ammonia, ethanol and phenylamine. Practical activity: The preparation of aspirin January 2012 Unit 4 Q10a June 2006 Unit 4 Q1 June 2005 Unit 4 Q7 June 2003 Unit 5 Q8b June 2010 Unit 4 Q7b and 7c Aspirin Aspirin screen experiment (not a suitable replacement for required practical 10) Further physical Chemistry 1 (8
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