advantages over disorder-specific CBT, but little is known about the effectiveness of this approach. Aims: The review aimed to summarize based clinical and cost-effectiveness data on transdiagnostic CBT for anxiety and depression. Method: A systematic review of electronic databases, including peer-reviewed and grey literature sources, was conducted (n = 1167 unique citations). Results: Eight trials were eligible for inclusion in the review. There was evidence of an effect for transdiagnostic CBT when compared to a control condition. There were no differences between transdiagnostic CBT and active treatments in two studies. We found no evidence of cost-effectiveness data. Conclusions: Quality assessment of the primary studies indicated a number of methodological concerns that may serve to inflate the observed effects of transdiagnostic approaches. Although there are positive signs of the value of transdiagnostic CBT, there is as yet insufficient evidence to recommend its use in place of disorder-specific CBT. Transdiagnostic, cognitive behaviour therapy, systematic review, Keywords: meta-analysis, methodological quality, evidence-base Introduction Depression and anxiety are highly prevalent (Kessler, Chiu, Demler, Merikangas and Walters, 2005; McManus, Meltzer, Brugha, Bebbington and Jenkins, 2009), have substantial impacts on quality of life and functioning for the individual (Haslam, Atkinson, Brown and Haslam, 2005; Paul and Moser, 2009) and are associated with substantial economic costs (Das-Munshi et al., 2008; Health and Safety Executive, 2012). Cognitive
advantages over disorder-specific CBT, but little is known about the effectiveness of this approach. Aims: The review aimed to summarize clinical and cost-effectiveness data on transdiagnostic CBT for anxiety and depression. Method: A systematic review of electronic databases, including peer-reviewed and grey literature sources, was conducted (n = 1167 unique citations). Results: Eight trials were eligible for inclusion in the review. There was evidence of an effect for transdiagnostic CBT when compared to a control condition. There were no differences between transdiagnostic CBT and active treatments in two studies. We found no evidence of cost-effectiveness data. Conclusions: Quality assessment of the primary studies indicated a number of methodological concerns that may serve to inflate the observed effects of transdiagnostic approaches. Although there are positive signs of the value of transdiagnostic CBT, there is as yet insufficient evidence to recommend its use in place of disorder-specific CBT. Keywords: Transdiagnostic, cognitive behaviour therapy, systematic review, meta-analysis, methodological quality, evidence-base Introduction Depression and anxiety are highly prevalent (Kessler, Chiu, Demler, Merikangas and Walters, 2005; McManus, Meltzer, Brugha, Bebbington and Jenkins, 2009), have substantial impacts on quality of life and functioning for the individual (Haslam, Atkinson, Brown and Haslam, 2005; Paul and Moser, 2009) and are associated with substantial economic costs (Das-Munshi et al., 2008; Health and Safety Executive, 2012). Cognitive based
Andersen_et_al._revised_Apr_2016.docx