Table A2. Overview of 36 Papers Relevant to Low Level Exposure to Asbestos for Asbestosis (Ordered by Study Type and Date) Original Study RMA ID Title Subjects Type of Level of Duration of Outcome: Study/Review Author Or Exposure Exposure Exposure (year) with asbestos exposure (RMA ID) or Review (fibre/mL) (but with no exposure Review of that Author data that could be Study (RMA ID) compared to the levels in the SoPs), producing Asbestosis; then Other Studies & Reviews Mortality Studies Paris et al RMA ID: Pleural Plaques 5545 retired workers Metal, Cumulative Duration of Morbidity study reporting (2009) 067601 and Asbestosis: exposure to asbestos construction Exposure Indexa: exposure: M=27.4 asbestos exposure and (100% men) and repairs M=49.6 (Estimated (SD=11.1) years producing asbestosis and Time-Response industry 80% had high level pleural plaques. Pleural 882=pleural plaques Time since 1st Relationships of exposure) plaques: Overall (n=882) exposure: M=41.9 375=asbestosis on HRCT Trend test p<0.0001. Concentration of (SD=8.1) years Data High exposure (n=777; exposure 17.5%) OR significant (fibre/mL) not (OR=2.89; 95%CI: 1.51, reported 5.52; p<0.0001). Asbestosis: Overall (n=375) Trend test p=0.01. High exposure (n=322; 7.3%) OR significant (OR=1.20; 95%CI: 0.62, 2.30; p=0.02). Only cumulative exposure (p<0.0001) or level of exposure (p=0.02) were significantly associated with asbestosis. Both time and dose-response relationships were demonstrated for pleural plaques. Only response relationships were shown for asbestosis. Author’s conclusion: Both and
Table A2. Overview of 36 Papers Relevant to Low Level Exposure to Asbestos for Asbestosis (Ordered by Study Type and Date) Original Study Author (RMA ID) or Review of that Study RMA ID Or Review Author (RMA ID) Title Subjects Type of Exposure Level of Exposure (fibre/mL) Duration of Exposure (year) Outcome: Study/Review with asbestos exposure (but with no exposure data that could be compared to the levels in the SoPs), producing Asbestosis; then Other Studies & Reviews Mortality Studies Paris et al (2009) RMA ID: 067601 Pleural Plaques and Asbestosis: and Time-Response Relationships on HRCT Data 5545 retired workers exposure to asbestos (100% men) 882=pleural plaques 375=asbestosis Metal, construction and repairs industry Cumulative Exposure Indexa: M=49.6 (Estimated 80% had high level of exposure) Concentration of exposure (fibre/mL) not reported Duration of exposure: M=27.4 (SD=11.1) years Time since 1st exposure: M=41.9 (SD=8.1) years Morbidity study reporting asbestos exposure producing asbestosis and pleural plaques. Pleural plaques: Overall (n=882) Trend test p<0.0001. High exposure (n=777; 17.5%) OR significant (OR=2.89; 95%CI: 1.51, 5.52; p<0.0001). Asbestosis: Overall (n=375) Trend test p=0.01. High exposure (n=322; 7.3%) OR significant (OR=1.20; 95%CI: 0.62, 2.30; p=0.02). Only cumulative exposure (p<0.0001) or level of exposure (p=0.02) were significantly associated with asbestosis. Both time and dose-response relationships were demonstrated for pleural plaques. Only relationships were shown for asbestosis. Author’s conclusion: Both and response
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