Eosinophilic Symptoms vary upon Mediators Any Multiple Likely Empiric diets site(s)/degree of that home persistent Endoscopy eosinophilic and activate inflammation. eosinophils SPT and/or sIgE Esophageal: dysphagia, play a role, pain. Generalized: e.g., eotaxin, APT not generally ascites, weight loss, IL-5. recommended edema, obstruction. Non-IgE mediated Food protein Primarily affects infants. Increased Infancy Cow’s milk, Usually SPT and/or sIgE Chronic exposure: TNF-alpha soy, rice, oat. resolves are typically enterocolitis emesis, diarrhea, poor response, Multiple other negative, but may syndrome growth, lethargy. decreased solids have become positive after restriction: response to been identified APT not helpful emesis, diarrhea, TGF-beta. hypotension (15%) 2 hours following ingestion. Food protein Mucus laden, bloody Eosinophilic Infancy Milk (via breast Usually Empiric diets induced stools in infants. inflammation feeding) resolves proctocolitis Heiner Rare disorder. Pulmonary Infant Milk Undefined No evidence of syndrome infiltrates, upper IgE. May have respiratory symptoms, precipitating failure to thrive, iron IgG deficiency anemia. antibodies.
Eosinophilic Symptoms vary upon site(s)/degree of eosinophilic inflammation. Esophageal: dysphagia, pain. Generalized: ascites, weight loss, edema, obstruction. Mediators that home and activate eosinophils play a role, e.g., eotaxin, IL-5. Any Multiple Likely persistent Empiric diets Endoscopy SPT and/or sIgE APT not generally recommended Non-IgE mediated Food protein enterocolitis syndrome Primarily affects infants. Chronic exposure: emesis, diarrhea, poor growth, lethargy. after restriction: emesis, diarrhea, hypotension (15%) 2 hours following ingestion. Increased TNF-alpha response, decreased response to TGF-beta. Infancy Cow’s milk, soy, rice, oat. Multiple other solids have been identified Usually resolves SPT and/or sIgE are typically negative, but may become positive APT not helpful Food protein induced proctocolitis Mucus laden, bloody stools in infants. Eosinophilic inflammation Infancy Milk (via breast feeding) Usually resolves Empiric diets Heiner syndrome Rare disorder. Pulmonary infiltrates, upper respiratory symptoms, failure to thrive, iron deficiency anemia. Infant Milk Undefined No evidence of IgE. May have precipitating IgG antibodies.
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