Supplementary Figure 1. Graphic representation of the differences in volumes (y axis) between ESES patients, healthy controls and refractory epilepsy controls (x axis). A. Left thalamic volume. B. Right thalamic volume. C. Total brain volume. The horizontal line represents the median, the limit of the box the interquartile range, and the whiskers the 5th and 95th percentiles respectively. In pairwise comparisons, left thalamic volume was smaller in ESES patients than in healthy controls (medians: 7.35 versus 7.74 cm3, Wilcoxon rank-sum test and in p=0.0055), refractory epilepsy controls than in healthy controls (7.09 versus 7.74 cm3, but was p=0.0001), not different between ESES patients and refractory epilepsy controls (7.35 versus 7.09 cm3, (Supplementary Figure 1A). p=0.358) The volume of the thalamus was different between the groups (Kruskal-Wallis test, (Supplementary Figure 1B). In pairwise comparisons, right thalamic volume was p=0.0002) smaller in ESES patients than in healthy controls (7.63 versus 7.99 cm3, Wilcoxon rank-sum test and in refractory epilepsy controls than in healthy controls (7.52 versus 7.99 cm3, p=0.0049), but was not different between ESES patients and refractory epilepsy controls p=0.0002), (medians: 7.63 versus 7.52 cm3, p=0.4837). The total brain volume was different between the groups (Kruskal-Wallis test, p=0.0001) (Supplementary Figure 1C). In pairwise comparisons, total brain volume was smaller in ESES patients than in healthy controls (1242.79 versus 1312.79, Wilcoxon rank-sum test and p=0.025), in refractory epilepsy controls than in healthy controls (1168.17 versus 1312.79, but p<0.00001), was larger in ESES patients than in refractory epilepsy controls (medians: 1242.79 versus 1168.17, p=0.0151).
Supplementary Figure 1. Graphic representation of the differences in volumes (y axis) between ESES patients, healthy controls and refractory epilepsy controls (x axis). A. Left thalamic volume. B. Right thalamic volume. C. Total brain volume. The horizontal line represents the median, the limit of the box the interquartile range, and the whiskers the 5th and 95th percentiles respectively. In pairwise comparisons, left thalamic volume was smaller in ESES patients than in healthy controls (medians: 7.35 versus 7.74 cm3, Wilcoxon rank-sum test p=0.0055), and in refractory epilepsy controls than in healthy controls (7.09 versus 7.74 cm3, p=0.0001), but was not different between ESES patients and refractory epilepsy controls (7.35 versus 7.09 cm3, p=0.358) (Supplementary Figure 1A). The volume of the thalamus was different between the groups (Kruskal-Wallis test, p=0.0002) (Supplementary Figure 1B). In pairwise comparisons, right thalamic volume was smaller in ESES patients than in healthy controls (7.63 versus 7.99 cm3, Wilcoxon rank-sum test p=0.0049), and in refractory epilepsy controls than in healthy controls (7.52 versus 7.99 cm3, p=0.0002), but was not different between ESES patients and refractory epilepsy controls (medians: 7.63 versus 7.52 cm3, p=0.4837). The total brain volume was different between the groups (Kruskal-Wallis test, p=0.0001) (Supplementary Figure 1C). In pairwise comparisons, total brain volume was smaller in ESES patients than in healthy controls (1242.79 versus 1312.79, Wilcoxon rank-sum test p=0.025), and in refractory epilepsy controls than in healthy controls (1168.17 versus 1312.79, p<0.00001), but was larger in ESES patients than in refractory epilepsy controls (medians: 1242.79 versus 1168.17, p=0.0151).
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