Appendix 3: Risk of bias of strata included in the systematic review Study Random sequence Allocation Blinding of Blinding of Incomplete outcome Selective generation (selection concealment participants and outcome data (attrition bias) reporting Other (dietary and bias) (selection bias) personnel assessors (reporting bias) exercise instructions; (performance (detection testing interval in bias) cross-over studies) bias)* Hartvigsen Low Subjects were Low The Low Crossover Low Not Low All 15 subjects Low Relevant Low Reduced 2014a randomly sequence design. stated completed the results by assigned to for each Subjects test according from overnight the sequence subject was complied to to the protocol. performed fasting, of the test kept in a instructions analyses sufficient breads by the closed before and were (1 week) study numbered during the reported. washout coordinator envelope trial. periods by use of a until combined Latin-Square interventions with design. were compliance assigned. to dietary and exercise instructions before and during the trial. Hartvigsen Low Subjects were Low To conceal Low Crossover Low Not Low All 15 subjects Low Relevant Low Sufficient 2014b randomly the design. stated completed the results (1 week) assigned to the sequence Subjects test according from washout until complied to to the protocol. performed periods sequence of the test meals by interventions instructions analyses combined the study were before and were with assigned, during the reported. compliance coordinator by the use of a the trial. to dietary Latin-Square sequence and design. for each exercise subject was instructions kept in a before and closed during the numbered trial. envelope.
Appendix 3: Risk of bias of strata included in the systematic review Study Random sequence generation (selection bias) Allocation concealment (selection bias) Blinding of participants and personnel (performance bias)* Blinding of outcome assessors (detection bias) Incomplete outcome data (attrition bias) Selective reporting (reporting bias) Other (dietary and exercise instructions; testing interval in cross-over studies) Hartvigsen 2014a Low Subjects were randomly assigned to the sequence of the test breads by the study coordinator by use of a Latin-Square design. Low The sequence for each subject was kept in a closed numbered envelope until interventions were assigned. Low Crossover design. Subjects complied to instructions before and during the trial. Low Not stated Low All 15 subjects completed the test according to the protocol. Low Relevant results from performed analyses were reported. Low Reduced by overnight fasting, sufficient (1 week) washout periods combined with compliance to dietary and exercise instructions before and during the trial. Hartvigsen 2014b Low Subjects were randomly assigned to the sequence of the test meals by the study coordinator by the use of a Latin-Square design. Low To conceal the sequence until interventions were assigned, the sequence for each subject was kept in a closed numbered envelope. Low Crossover design. Subjects complied to instructions before and during the trial. Low Not stated Low All 15 subjects completed the test according to the protocol. Low Relevant results from performed analyses were reported. Low Sufficient (1 week) washout periods combined with compliance to dietary and exercise instructions before and during the trial.
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