Appendix 9: Evidence relating to the use of dressings in the management of radiotherapy induced skin reactions ++= high quality study += acceptable quality 0= rejected, unacceptable quality not able to score= study had no control/comparison group or a case series Dressing Type Product Design of Study Reference Main Findings and Quality (including method, Limitations Assessment sample and main outcomes) Silicone-based Mepilex®Lite Systematic controlled Diggelmann, K., Mepilex®Lite dressings 0 foam clinical trial (patients as Zytkovicz, A., Tuaine statistically significantly Low adhesion own control) comparing ,J. et al. 2010. decreased the extent of Mepilex®Lite and Mepilex ®Lite radiation-induced erythema Aqueous cream BP in dressings for the (p<0.001) although the women treated with management of average increase in erythema radical RT to breast radiation-induced score for Mepilex® Lite was N=24 evaluable erythema: a 1.65 and the average Outcomes: systematic inpatient increase in erythema score controlled clinical trial. for Aqueous cream BP was Skin Reaction Assessment Scale (RISRAS), Brit J Radiol 83: 2.41 (average difference dose build-up, skin (995), 971–8. =0.76) giving an average temperature difference less than one category point on the scale so may not be clinically significant. The majority of women preferred them. Bolus
Appendix 9: Evidence relating to the use of dressings in the management of radiotherapy induced skin reactions ++= high quality study += acceptable quality 0= rejected, unacceptable quality not able to score= study had no control/comparison group or a case series Dressing Type Product Design of Study (including method, sample and main outcomes) Reference Main Findings and Limitations Quality Assessment Silicone-based foam Low adhesion Mepilex®Lite Systematic controlled clinical trial (patients as own control) comparing Mepilex®Lite and Aqueous cream BP in women treated with radical RT to breast N=24 evaluable Outcomes: Skin Reaction Assessment Scale (RISRAS), dose build-up, skin temperature Diggelmann, K., Zytkovicz, A., Tuaine ,J. et al. 2010. Mepilex ®Lite dressings for the management of radiation-induced erythema: a systematic inpatient controlled clinical trial. Brit J Radiol 83: (995), 971–8. Mepilex®Lite dressings statistically significantly decreased the extent of radiation-induced erythema (p<0.001) although the average increase in erythema score for Mepilex® Lite was 1.65 and the average increase in erythema score for Aqueous cream BP was 2.41 (average difference =0.76) giving an average difference less than one category point on the scale so may not be clinically significant. The majority of women preferred them. Bolus 0
appendix_9_-_dressings_table.docx