Table S1 Key model assumptions Assumption Justification The available data consisted Constant of the number exacerbation of trial through exacerbations time and and number of treatment patients per Transitions duration. treatment between Exacerbations group over the health classified into follow-up of states clinically the RCTs. significant The severe and classification clinically of significant exacerbations severe. corresponded to the
Table S1 Key model assumptions Assumption Justification Transitions between health states Constant exacerbation through time and treatment duration. Exacerbations classified into clinically significant and clinically significant severe. The available data consisted of the number of exacerbations and number of patients per treatment group over the follow-up of the RCTs. The classification of exacerbations corresponded to the severe trial
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