Table S4: Points of departure derived for symphytinea. Dose(mg/kg bw/day) T10 T25 Species Gender Tumour Type Malignant (mg/kg bw/day) (mg/kg bw/day) 0 6.26 liver cell adenomas No 31 12 0/20b 1/20 Hemangioendothelial sarcoma Yes 10 4.0 0/20 3/20 of the liver Myeloid leukemia No - 1/20 1/20 Rat Male Interstitial cell tumour of the testis No - 1/20 0/20 Fibroma of the back No - 1/20 0/20 a The data from Hirono et al.(1979) b Italic number represents cancer number of test animals
Table S4: Points of departure derived for symphytinea. Species Gender Tumour Type Malignant Dose(mg/kg bw/day) T25 (mg/kg bw/day) T10 (mg/kg bw/day) 0 6.26 Rat Male liver cell adenomas No 0/20b 1/20 31 12 Hemangioendothelial sarcoma of the liver Yes 0/20 3/20 10 4.0 Myeloid leukemia No 1/20 1/20 - Interstitial cell tumour of the testis No 1/20 0/20 - Fibroma of the back No 1/20 0/20 - a The data from Hirono et al.(1979) b Italic number represents cancer number of test animals
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