Significant -ve trends: *CMM women 0.57 (0.32, 1.02) p for trend =0.04 ** multiple myeloma 0.45 (0.24, 0.84) p for trend=0.01 Significant +ve trends: ** all cancers 1.09 (1.02,1.16) p for trend=0.002 **mouth & pharynx 1.09 (1.02, 1.16) p for trend=0.006 **NHL 1.47 (1.06, 2.04) p for trend=0.01 *PM breast cancer 1.17 (0.91,1.49) p=0.03 Breast () CLA, Country: Finland Dietary Age, area, vs quintile of Serum & Intake: Inv ↑ ↓ F energy. Age at intake vaccenic acid N=433 assessment: assoc with BC. Case=225 110 item menarche, age Dietary CLA: CLA, vaccenic Control =208 validated FFQ at 1st baby, OC, PM women OR 0.3 70% reduction with Case-control acid intake & Age 52.6 (25-75y) completed at Oestrogen, FHx, (0.1, 0.7) higher intake of CLA BC home, checked by BBD, education, Dietary trans-vaccenic TFA intake: g/day nurse at alcohol, acid: 80% reduction in risk C18:1 trans: 1.17 interview. smoking, PAL, no signif seen with higher serum ±0.54 Finnish food WHR, BMI CLA and 80% reduction Vaccenic acid: 0.28 comp database vs quintile of with higher serum of ↑ ↓ ±0.14 FA: trans-vaccenic acid. CLA: 0.13± 0.06 FA: In PM women Total: 0.52 gas liquid Trans-vaccenic acid: It is possible to CLA & ↑ chromatography OR 0.2 (95% CI trans-vaccenic acid in 0.1,0.6)
Significant -ve trends: *CMM women 0.57 (0.32, 1.02) p for trend =0.04 ** multiple myeloma 0.45 (0.24, 0.84) p for trend=0.01 Significant +ve trends: ** all cancers 1.09 (1.02,1.16) p for trend=0.002 **mouth & pharynx 1.09 (1.02, 1.16) p for trend=0.006 **NHL 1.47 (1.06, 2.04) p for trend=0.01 *PM breast cancer 1.17 (0.91,1.49) p=0.03 Breast () Case-control CLA, vaccenic acid CLA, vaccenic acid intake & BC Country: Finland N=433 F Case=225 Control =208 Age 52.6 (25-75y) TFA intake: g/day C18:1 trans: 1.17 ±0.54 Vaccenic acid: 0.28 ±0.14 CLA: 0.13± 0.06 Total: 0.52 Dietary assessment: 110 item validated FFQ completed at home, checked by nurse at interview. Finnish food comp database FA: gas liquid chromatography Age, area, energy. Age at menarche, age at 1st baby, OC, Oestrogen, FHx, BBD, education, alcohol, smoking, PAL, WHR, BMI ↑ vs ↓ quintile of intake Dietary CLA: PM women OR 0.3 (0.1, 0.7) Dietary trans-vaccenic acid: no signif ↑ vs ↓ quintile of FA: In PM women Trans-vaccenic acid: OR 0.2 (95% CI 0.1,0.6) Serum & Intake: Inv assoc with BC. 70% reduction with higher intake of CLA 80% reduction in risk seen with higher serum CLA and 80% reduction with higher serum of trans-vaccenic acid. It is possible to ↑ CLA & trans-vaccenic acid in
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