Appendix 5: Summary of Evidence: RCT/Systematic reviews ++ = high quality study + = acceptable quality 0 = rejected, unacceptable quality Author and Description Scale or other n Intervention Category of Category Results P-value QA Year measuring and control patients (primary tool endpoint) Butcher et Systematic 10 N/A Breast All + al 2012 review Chan et al Systematic 47 Trials of oral All included Radiation 36/47 of ++ 2014 Review RCTs systemic Induced skin included from therapies reaction articles (n=6) considered Washing at high risk practices of bias (n=2) 10/47 rated Deodorant at unclear use (n=4) risk Topical Allocation steroids concealment (n=5) only reported in 22/47 topical studies therapies Blinding and (n=23) attrition only Dressings adequately (n=6) described Light 21/47 emitting diode
Appendix 5: Summary of Evidence: RCT/Systematic reviews ++ = high quality study + = acceptable quality 0 = rejected, unacceptable quality Author and Year Description Scale or other measuring tool n Intervention and control Category of patients Category (primary endpoint) Results P-value QA Butcher et al 2012 Systematic review 10 N/A Breast All + Chan et al 2014 Systematic Review 47 RCTs from Trials of oral systemic therapies (n=6) Washing practices (n=2) Deodorant use (n=4) Topical steroids (n=5) topical therapies (n=23) Dressings (n=6) Light emitting diode All included Radiation Induced skin reaction 36/47 of included articles considered at high risk of bias 10/47 rated at unclear risk Allocation concealment only reported in 22/47 studies Blinding and attrition only adequately described 21/47 ++
appendix_5_-_summary_of_evidence.docx