F: 22-35 days (DN08069) Pregnant mice 60 57.8 15.7 10-day oral DRF 125 603 163 (DN08014/DCN 930068598) 250 1810 491 500 2380 645 Mouse 10 0.851 0.2 Oral EFD, 10 days GD15 50 19.1 5.2 (DN08022) 250 737 200 500 1740 472 Nonpregnant 50 0.707 0.2 Rabbits 150 2.55 5 days oral Exploratory (DN08015/DCN 300 5.52 1.5 930068281) Nonpregnant 250 3.06 0.8 Rabbits 500 4.11 1.1 days oral Exploratory (DN09022/DCN 750 5.61 1.5 930068775) 1000 12.3 3.3 Pregnant Rabbits 13-Day 50 0.76 0.2 oral DRF, 100 2.11 0.6 GD19 (DN08021/DCN 930068624) 200 5.02 1.4 400 10.6 2.9 Rabbit 50 1.17 0.3 Oral EFD, 13 days 100 2.79 0.8 (DN08056/DCN 930043164) 200 4.4 1.2 Rat 40 26.8 7.3 Oral pre/postnatal 125 282 76 development GD 6-LD 20, (DN11186) 400 711 193
F: 22-35 days (DN08069) Pregnant mice 10-day oral DRF (DN08014/DCN 930068598) 60 57.8 15.7 125 603 163 250 1810 491 500 2380 645 Mouse Oral EFD, 10 days GD15 (DN08022) 10 0.851 0.2 50 19.1 5.2 250 737 200 500 1740 472 Nonpregnant Rabbits 5 days oral Exploratory (DN08015/DCN 930068281) 50 0.707 0.2 150 2.55 300 5.52 1.5 Nonpregnant Rabbits days oral Exploratory (DN09022/DCN 930068775) 250 3.06 0.8 500 4.11 1.1 750 5.61 1.5 1000 12.3 3.3 Pregnant Rabbits 13-Day oral DRF, GD19 (DN08021/DCN 930068624) 50 0.76 0.2 100 2.11 0.6 200 5.02 1.4 400 10.6 2.9 Rabbit Oral EFD, 13 days (DN08056/DCN 930043164) 50 1.17 0.3 100 2.79 0.8 200 4.4 1.2 Rat Oral pre/postnatal development GD 6-LD 20, (DN11186) 40 26.8 7.3 125 282 76 400 711 193
auspar-asunaprevir-151214.docx