scored by difference for clinicians medial applied creams 18% (Sorbolene) vs. 28% (moisturizing double barrier cream) Sharp et al Blinded RCT RTOG 411 Calendula Breast Follow up ARSR p=0.55. ++ 2013 EORTC QLQ Weleda® (RTOG grade C30, cream vs. was 23% ≥2) a visual Essex® in the analogue (Aqueous) Calendula scale patient cream group and experience 19% in the and Aqueous adherence cream group at follow up Ulff et al Double RTOG 125 Betsmethasone Breast RTOG 0-1 22/53 B+E ++ 2013 Blinded RCT Colorimeter (steroid) 7/49 P=0.001 3 arm VAS cream moisturisers DLQI (B+E) RTOG 3 vs. 7/53 B+E Essex® cream 15/49 vs. moisturisers Canoderm® cream et al Single centre RISRASS 88 Mepilex® lite Time to wound Mepilex® 0 2013 RCT dressing vs. Nasopharynx healing median time normal skin to wound care (cleaning healing 16 with salted days (95% CI water) 12-19)
scored by clinicians difference for medial applied creams 18% (Sorbolene) vs. 28% (moisturizing double barrier cream) Sharp et al 2013 Blinded RCT RTOG EORTC QLQ C30, a visual analogue scale patient experience and adherence 411 Calendula Weleda® cream vs. Essex® (Aqueous) cream Breast Follow up ARSR (RTOG grade ≥2) was 23% in the Calendula group and 19% in the Aqueous cream group at follow up p=0.55. ++ Ulff et al 2013 Double Blinded RCT 3 arm RTOG Colorimeter VAS DLQI 125 Betsmethasone (steroid) cream (B+E) vs. Essex® cream vs. Canoderm® cream Breast RTOG 0-1 RTOG 3 22/53 B+E 7/49 moisturisers 7/53 B+E 15/49 moisturisers P=0.001 ++ et al 2013 Single centre RCT RISRASS 88 Mepilex® lite dressing vs. normal skin care (cleaning with salted water) Nasopharynx Time to wound healing Mepilex® median time to wound healing 16 days (95% CI 12-19) 0
appendix_5_-_summary_of_evidence.docx