days of CTX infusion and and Nausea and vomiting were CINV control than patients with the genotype dexamethasone dichotomized as total control other genotypes (67.7% versus ABCB1 (100%) (i.e., absence of any degree 47.1%, p = 0.032) Association between of nausea and absence of any response to antiemetic degree of vomiting: yes/no) Patients with the TT-TT-TT for the treatment and gene, as compared to other ABCB1 haplotypes Mann-Whitney used to genotypes, had a higher acute CINV U-test measure differences in response when using granisetron antiemetic response rate (68.4% versus 44.1%, p = 0.048) but genotypes. not ondansetron (66.7% versus ABCB1 52.8%, p = 0.374) Logistic regression to determine association In the delayed phase, no significant between clinical factors, change was found between complete demographic factors, control of CINV and genotypes genotype and CINV Results of logistic regression analysis found that during the acute phase, total control of CINV was significantly increased by the absence of previous CINV (p < 0.0001) and the 3435 TT ABCB1 genotype (p = 0.021), but not by gender (p = 0.052), age (p = 0.071), 2677 TT genotype (p = ABCB1 0.069) and TT genotype ABCB11236 (p = 0.069)
days of CTX infusion and ABCB1 genotype Association between response to antiemetic treatment and ABCB1 haplotypes and dexamethasone (100%) Nausea and vomiting were dichotomized as total control (i.e., absence of any degree of nausea and absence of any degree of vomiting: yes/no) Mann-Whitney U-test used to measure differences in antiemetic response rate ABCB1 genotypes. Logistic regression to determine association between clinical factors, demographic factors, genotype and CINV CINV control than patients with the other genotypes (67.7% versus 47.1%, p = 0.032) Patients with the TT-TT-TT for the gene, as compared to other genotypes, had a higher acute CINV response when using granisetron (68.4% versus 44.1%, p = 0.048) but not ondansetron (66.7% versus 52.8%, p = 0.374) In the delayed phase, no significant change was found between complete control of CINV and genotypes Results of logistic regression analysis found that during the acute phase, total control of CINV was significantly increased by the absence of previous CINV (p < 0.0001) and the ABCB1 3435 TT genotype (p = 0.021), but not by gender (p = 0.052), age (p = 0.071), ABCB1 2677 TT genotype (p = 0.069) and ABCB11236 TT genotype (p = 0.069)
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