Rabbit Drug Dose and Frequency Inhalation anesthetics Recommended: 1-3% inhalant Whenever general Survival surgery requires concurrent Isoflurane or to effect (up to anesthesia is preemptive analgesia. Sevoflurane 5% for required Must use precision vaporizer. Mask or induction). chamber induction without injected pre- Up to 8% for medication may result in breath-holding and Sevoflurane injury. Nitrous oxide Up to 60% Whenever deep Not acceptable for surgery as sole – (N20) with oxygen sedation or must be used with inhalant anesthetic to general anesthesia potentiate effect and lower required dose. is required Ketamine combinations Recommended: 35-50 mg/kg + As needed May not produce surgical-plane anesthesia Ketamine- 5-10 mg/kg for major procedures. If redosing, use Xylazine IM or SC (in ketamine alone. May be partially reversed same syringe with Atipamezole or Yohimbine. Note that or with IM Ketamine combinations often sting upon injection. xylazine administered 10-20 minutes in advance) Ketamine alone 20-60 mg/kg As needed Deep sedation, but not surgical anesthesia. IM or SC Should not often use alone. Examples are sedation prior to euthanasia via cervical dislocation or a minor non-invasive procedure like catheter placement. Note that IM Ketamine combinations often sting upon injection. 35-50 mg/kg + As needed Ketamine- May not produce surgical-plane anesthesia Medetomidine 0.5 mg/kg IM for major procedures. If redosing, use or SC (in same ketamine alone. May be partially reversed syringe, or with Atipamezole . Note that IM Ketamine with combinations often sting upon injection. medetomidine administered 10-20 minutes in advance)
Rabbit Drug Dose and Frequency Inhalation anesthetics Recommended: Isoflurane or Sevoflurane 1-3% inhalant to effect (up to 5% for induction). Up to 8% for Sevoflurane Whenever general anesthesia is required Survival surgery requires concurrent preemptive analgesia. Must use precision vaporizer. Mask or chamber induction without injected pre- medication may result in breath-holding and injury. Nitrous oxide (N20) Up to 60% with oxygen Whenever deep sedation or general anesthesia is required Not acceptable for surgery as sole – must be used with inhalant anesthetic to potentiate effect and lower required dose. Ketamine combinations Recommended: Ketamine- Xylazine 35-50 mg/kg + 5-10 mg/kg IM or SC (in same syringe or with xylazine administered 10-20 minutes in advance) As needed May not produce surgical-plane anesthesia for major procedures. If redosing, use ketamine alone. May be partially reversed with Atipamezole or Yohimbine. Note that IM Ketamine combinations often sting upon injection. Ketamine alone 20-60 mg/kg IM or SC As needed Deep sedation, but not surgical anesthesia. Should not often use alone. Examples are sedation prior to euthanasia via cervical dislocation or a minor non-invasive procedure like catheter placement. Note that IM Ketamine combinations often sting upon injection. Ketamine- Medetomidine 35-50 mg/kg + 0.5 mg/kg IM or SC (in same syringe, or with medetomidine administered 10-20 minutes in advance) As needed May not produce surgical-plane anesthesia for major procedures. If redosing, use ketamine alone. May be partially reversed with Atipamezole . Note that IM Ketamine combinations often sting upon injection.
Anesthesia_in_Laboratory_Animals.docx