48 hours 2 4.7 mL 72 hours 3 7 mL 96 hours 4 9.3 mL *Extractable amount per vial is 35 micrograms in a volume of 2.8 mL reconstituted solution. Table 8. For Patients Weighing Less Than 45 kg: Volume of Blincyto required for 250 mL cassette for 5 mcg/m2/day Dose Expected Number of Volume of Blincyto vials Dose Cassette Duration BSA (m2) Reconstituted required* BLINCYTO 1 1.5 1.59 0.65 – 1 1.4 1.49 0.6 – 1 1.3 1.39 0.56 – 1 1.2 1.29 0.52 – 1 1.1 1.19 0.48 – 1 1 1.09 0.44 – 24 hours 1 0.9 0.99 0.39 – 1 0.8 0.89 0.35 – 1 0.7 0.79 0.31 – 5 mcg/m2/day 1 0.6 0.69 0.27 – 1 0.5 0.59 0.23 – 1 0.4 0.49 0.19 – 1 1.5 1.59 1.3 – 1 1.4 1.49 1.2 – 48 1 1.3 1.39 1.1 – 1 1.2 1.29 1 – 1 1.1 1.19 0.95 –
48 hours 2 4.7 mL 72 hours 3 7 mL 96 hours 4 9.3 mL *Extractable amount per vial is 35 micrograms in a volume of 2.8 mL reconstituted solution. Table 8. For Patients Weighing Less Than 45 kg: Volume of Blincyto required for 250 mL cassette for 5 mcg/m2/day Dose Dose Cassette Duration Expected Number of Blincyto vials required* BSA (m2) Volume of Reconstituted BLINCYTO 5 mcg/m2/day 24 hours 1 1.5 – 1.59 0.65 1 1.4 – 1.49 0.6 1 1.3 – 1.39 0.56 1 1.2 – 1.29 0.52 1 1.1 – 1.19 0.48 1 1 – 1.09 0.44 1 0.9 – 0.99 0.39 1 0.8 – 0.89 0.35 1 0.7 – 0.79 0.31 1 0.6 – 0.69 0.27 1 0.5 – 0.59 0.23 1 0.4 – 0.49 0.19 48 1 1.5 – 1.59 1.3 1 1.4 – 1.49 1.2 1 1.3 – 1.39 1.1 1 1.2 – 1.29 1 1 1.1 – 1.19 0.95
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