Table 1. Studies that Show Brain Biomarkers Correlate with Mercury Levels in Children with ASD Biomarker Authors and N Purpose of Findings Journal Study Age Brain Tissue Mostafa and ASD 40 Serum Higher seropositivity for Autoantibodies [26] Controls 40 antineuronal antineuronal antibodies and (antineuronal Egypt J Pediatr antibodies and higher blood mercury in antibodies) Allergy Immunol 3-8 y blood mercury autism vs. controls. levels were Seropositivity of estimated antineuronal antibodies had between autism positive association with and controls elevated blood mercury (found in 70% of autistic children). Both markers positively associated with behavioral abnormalities, autistic regression, EEG abnormalities Brain Tissue Mostafa and ASD 50 Blood mercury Serum levels of blood Autoantibodies [27] Controls 30 levels and mercury were significantly (anti-MBP Clin Cell Immunol seropositivity of higher in autistic children 5-12 y anti-MBP than healthy controls; autoantibodies in increased levels of blood autistic children mercury were found in 48% of autistic patients, and 72% of autistic children had anti-MBP auto-antibodies. There was a significant positive association between the elevated levels of blood mercury and anti-MBP auto-antibodies in autistic children.
Table 1. Studies that Show Brain Biomarkers Correlate with Mercury Levels in Children with ASD Biomarker Authors and Journal N Age Purpose of Study Findings Brain Tissue Autoantibodies (antineuronal antibodies) Mostafa and [26] Egypt J Pediatr Allergy Immunol ASD 40 Controls 40 3-8 y Serum antineuronal antibodies and blood mercury levels were estimated between autism and controls Higher seropositivity for antineuronal antibodies and higher blood mercury in autism vs. controls. Seropositivity of antineuronal antibodies had positive association with elevated blood mercury (found in 70% of autistic children). Both markers positively associated with behavioral abnormalities, autistic regression, EEG abnormalities Brain Tissue Autoantibodies (anti-MBP Mostafa and [27] Clin Cell Immunol ASD 50 Controls 30 5-12 y Blood mercury levels and seropositivity of anti-MBP autoantibodies in autistic children Serum levels of blood mercury were significantly higher in autistic children than healthy controls; increased levels of blood mercury were found in 48% of autistic patients, and 72% of autistic children had anti-MBP auto-antibodies. There was a significant positive association between the elevated levels of blood mercury and anti-MBP auto-antibodies in autistic children.
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