The contraindications to ribavirin also apply to this combination regimen. Refer to the ribavirin prescribing information for a list of contraindications for ribavirin. TECHNIVIE is contraindicated: In patients with severe hepatic impairment (Child-Pugh C) due to risk of potential toxicity [see Use in Specific Populations and Clinical Pharmacology)]. With drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. With drugs that are moderate or strong inducers of CYP3A and may lead to reduced efficacy of TECHNIVIE. In patients with known hypersensitivity to ritonavir (e.g. toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome). lists drugs that are contraindicated with TECHNIVIE (see INTERACTIONS WITH OTHER MEDICINES). 4– Drugs that are contraindicated with TECHNIVIE Drug(s) within Class Clinical Comments Drug that are Contraindicated Alpha1-adrenoreceptor Alfuzosin HCl Potential for hypotension. antagonist Antianginal Ranolazine Potential for serious and/or life-threatening reactions Antiarrhythmics Amiodarone, quinidine Potential for cardiac arrhythmias. Dronedarone Potential for serious and/or life-threatening reactions such as cardiac arrhythmias Anticonvulsants Carbamazepine, Ombitasvir, paritaprevir and ritonavir exposures phenytoin, may decrease leading to a potential loss of phenobarbital therapeutic activity of TECHNIVIE. Antihistamines (for Astemizole, Potential for cardiac arrhythmias. systemic use) terfenadine Antigout medications Colchicine (in patients Potential for serious and/or life-threatening with renal or hepatic reactions in patients with renal and/or hepatic impairment) impairment. Antimycobacterial Rifampicin Ombitasvir, paritaprevir and ritonavir exposures may decrease leading to a potential loss of therapeutic activity of TECHNIVIE. Antipsychotic Blonanserin No information on potential effects is currently available
The contraindications to ribavirin also apply to this combination regimen. Refer to the ribavirin prescribing information for a list of contraindications for ribavirin. TECHNIVIE is contraindicated: In patients with severe hepatic impairment (Child-Pugh C) due to risk of potential toxicity [see Use in Specific Populations and Clinical Pharmacology)]. With drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. With drugs that are moderate or strong inducers of CYP3A and may lead to reduced efficacy of TECHNIVIE. In patients with known hypersensitivity to ritonavir (e.g. toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome). lists drugs that are contraindicated with TECHNIVIE (see INTERACTIONS WITH OTHER MEDICINES). 4– Drugs that are contraindicated with TECHNIVIE Drug Drug(s) within Class that are Contraindicated Clinical Comments Alpha1-adrenoreceptor antagonist Alfuzosin HCl Potential for hypotension. Antianginal Ranolazine Potential for serious and/or life-threatening reactions Antiarrhythmics Amiodarone, quinidine Potential for cardiac arrhythmias. Dronedarone Potential for serious and/or life-threatening reactions such as cardiac arrhythmias Anticonvulsants Carbamazepine, phenytoin, phenobarbital Ombitasvir, paritaprevir and ritonavir exposures may decrease leading to a potential loss of therapeutic activity of TECHNIVIE. Antihistamines (for systemic use) Astemizole, terfenadine Potential for cardiac arrhythmias. Antigout medications Colchicine (in patients with renal or hepatic impairment) Potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment. Antimycobacterial Rifampicin Ombitasvir, paritaprevir and ritonavir exposures may decrease leading to a potential loss of therapeutic activity of TECHNIVIE. Antipsychotic Blonanserin No information on potential effects is currently available
auspar-paritaprevir-ritonavir-ombitasvir-171005-pi.docx