Type Title Figure Box plots of change from baseline in continuous ECG parameters by time-point for each treatment Figure Estimated mean difference in comparison to placebo and 90% CI for change from baseline in QTc (∆∆QTc) for treatment Figure Estimated mean difference in comparison to placebo and 90% CI for change from baseline in QTc (∆∆QTc) for active control Figure Raw mean (+/-SE) change from baseline in continuous ECG parameters by treatment Figure Concentration response for change from baseline in QTc for active control (assay-sensitivity) Figure Concentration response for change from baseline in QTc for treatment Table Treatment comparisons of change from baseline in QTc intervals by time for treatment Treatment comparisons of change from baseline in QTc intervals by time for active control Table Treatment comparisons of change from baseline to all time points in ECG parameters (HR, PR, QRS) by time for treatment Table Summary of values and changes from baseline to all time points in ECG parameters by time and treatment Table Number and percentage of subjects meeting or exceeding clinically noteworthy QT and QTc interval changes by time and overall Table Number and percentage of subjects meeting or exceeding clinically noteworthy PR, QRS and HR interval changes by time point and overall Table Number and percentage of subjects with abnormal morphological/qualitative ECG findings Listing ECG intervals (average over repeated measurements) Listing Change from baseline in ECG intervals (average over repeated measurements) Listing ECG intervals (each replicate) Listing ST segment, T-wave and U-wave morphology Listing ECG findings
Type Title Figure Box plots of change from baseline in continuous ECG parameters by time-point for each treatment Figure Estimated mean difference in comparison to placebo and 90% CI for change from baseline in QTc (∆∆QTc) for treatment Figure Estimated mean difference in comparison to placebo and 90% CI for change from baseline in QTc (∆∆QTc) for active control Figure Raw mean (+/-SE) change from baseline in continuous ECG parameters by treatment Figure Concentration response for change from baseline in QTc for active control (assay-sensitivity) Figure Concentration response for change from baseline in QTc for treatment Table Treatment comparisons of change from baseline in QTc intervals by time for treatment Treatment comparisons of change from baseline in QTc intervals by time for active control Table Treatment comparisons of change from baseline to all time points in ECG parameters (HR, PR, QRS) by time for treatment Table Summary of values and changes from baseline to all time points in ECG parameters by time and treatment Table Number and percentage of subjects meeting or exceeding clinically noteworthy QT and QTc interval changes by time and overall Table Number and percentage of subjects meeting or exceeding clinically noteworthy PR, QRS and HR interval changes by time point and overall Table Number and percentage of subjects with abnormal morphological/qualitative ECG findings Listing ECG intervals (average over repeated measurements) Listing Change from baseline in ECG intervals (average over repeated measurements) Listing ECG intervals (each replicate) Listing ST segment, T-wave and U-wave morphology Listing ECG findings
analyses-displays-associated-with-thorough-qtqtc-studies-version-10-11-mar-16-11813.docx