Figure 1S. Chemical structures of A) Methyl p-toluenesulfonate (MTS), B)Isopropyl p-toluenesulfonate (ITS) and C) Aprepitant Figure 2S. Normal probability and the residuals vs predicted for the studied CMAs. Response RS(1) RS(2) Rt Response NMTS NITS Figure 3S. Blank Aprepitant sample spiked with impurities 1-6, Toluene, MTS and ITS at the respective specification limit. The impurity 4 was not detected under the specific conditions due to its co-elution with Aprepitant peak.
Figure 1S. Chemical structures of A) Methyl p-toluenesulfonate (MTS), B)Isopropyl p-toluenesulfonate (ITS) and C) Aprepitant Figure 2S. Normal probability and the residuals vs predicted for the studied CMAs. Response RS(1) RS(2) Rt Response NMTS NITS Figure 3S. Blank Aprepitant sample spiked with impurities 1-6, Toluene, MTS and ITS at the respective specification limit. The impurity 4 was not detected under the specific conditions due to its co-elution with Aprepitant peak.
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