Supplementary table The properties of 14 TAAs. Oncoproteins Molecular Cellular location properties/functions Ref. size IMP1 63.5 KD Cytoplasm insulin-like growth factor 2 mRNA [17,18] binding protein 1 IMP2/p62 66.1 KD Nucleus insulin-like growth factor 2 mRNA [18,19] binding protein 2 IMP3/Koc 63.7 KD Nucleus; Cytoplasm insulin-like growth factor 2 mRNA [17,18,20] binding protein 3/K homology protein overexpressed in cancer CIP2A/p90 102.2 KD Membrane; Cytoplasm cancerous inhibitor of protein [19,21] phosphatase 2A (PP2A) RalA 23.6 KD Cell surface; Cell ras-like GTP-binding protein [22] membrane. c-Myc 48.8 KD Nucleus transcription factor oncoprotein [23,24] survivin 16.4 KD Cytoplasm; Nucleus; inhibitor of apoptosis [25,26] Chromosome. cyclin B1 48.3 KD Cytoplasm; Nucleus cell-cycle nuclear protein [27] 14-3-3 27.7 KD Cytoplasm mediate signal transduction by [28,29] ζ binding to phosphoserine-containing proteins MDM2 55.2 KD Nucleus; Cytoplasm nuclear phosphoprotein that binds [30,31] and inhibits transactivation by tumor protein p53 suppressor proteins p53 53 KD Cytoplasm; Nucleus tumor suppressor protein containing [32,33] transcriptional activation, DNA binding, and oligomerization domains. Ink4a/p16 16.5 KD Cytoplasm; Nucleus cyclin-dependent kinase inhibitor [34,35] NPM1/B23 32.6 KD Nucleolus nucleolar phosphoprotein involved [36,37] in several processes including regulation of the ARF/p53 pathway CAPERα/HCC1.4 59.4 KD Nucleus (concentrated in mRNA binding protein, steroid [38,39] nuclear speckles) hormone receptor-mediated transcription and alternative splicing
Supplementary table The properties of 14 TAAs. Oncoproteins Molecular size Cellular location properties/functions Ref. IMP1 63.5 KD Cytoplasm insulin-like growth factor 2 mRNA binding protein 1 [17,18] IMP2/p62 66.1 KD Nucleus insulin-like growth factor 2 mRNA binding protein 2 [18,19] IMP3/Koc 63.7 KD Nucleus; Cytoplasm insulin-like growth factor 2 mRNA binding protein 3/K homology protein overexpressed in cancer [17,18,20] CIP2A/p90 102.2 KD Membrane; Cytoplasm cancerous inhibitor of protein phosphatase 2A (PP2A) [19,21] RalA 23.6 KD Cell surface; Cell membrane. ras-like GTP-binding protein [22] c-Myc 48.8 KD Nucleus transcription factor oncoprotein [23,24] survivin 16.4 KD Cytoplasm; Nucleus; Chromosome. inhibitor of apoptosis [25,26] cyclin B1 48.3 KD Cytoplasm; Nucleus cell-cycle nuclear protein [27] 14-3-3 ζ 27.7 KD Cytoplasm mediate signal transduction by binding to phosphoserine-containing proteins [28,29] MDM2 55.2 KD Nucleus; Cytoplasm nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53 [30,31] suppressor proteins p53 53 KD Cytoplasm; Nucleus tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. [32,33] Ink4a/p16 16.5 KD Cytoplasm; Nucleus cyclin-dependent kinase inhibitor [34,35] NPM1/B23 32.6 KD Nucleolus nucleolar phosphoprotein involved in several processes including regulation of the ARF/p53 pathway [36,37] CAPERα/HCC1.4 59.4 KD Nucleus (concentrated in nuclear speckles) mRNA binding protein, steroid hormone receptor-mediated transcription and alternative splicing [38,39]
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