NAME OF THE MEDICINE NOCDURNA® sublingual wafers Desmopressin Synonyms of desmopressin: DDAVP 1-Desamino-8-D-Arginine vasopressin. Desamino-cys-1-D-Arginine-8-vasopressin. CAS Nos.: Desmopressin base 16679-58-6 Desmopressin acetate 62288-83-9 Molecular formula and molecular mass: C48H74N14O17S2 (acetate trihydrate) MW = 1183.2 C46H64N14O12S2 (free base) MW = 1069.2 Physical and chemical characteristics: A white, fluffy powder, soluble in water, in alcohol and in glacial acetic acid. DESCRIPTION NOCDURNA, a sublingual wafer, contains the active substance, desmopressin (present as the hydrated acetate), a synthetic structural analogue of the natural pituitary hormone, arginine vasopressin. The difference lies in the desamination of cysteine and substitution of L-arginine by D-arginine. NOCDURNA also contains gelatin, mannitol and citric acid. PHARMACOLOGY Pharmacodynamics Pharmacotherapeutic group: Vasopressin and analogues. ATC code: H01B A02 Mechanism of action NOCDURNA contains desmopressin, a synthetic analogue of naturally occurring anti-diuretic hormone arginine vasopressin (AVP). Desmopressin mimics vasopressin’s anti-diuretic effect, binding to the V2 receptors in the renal collecting tubules of the kidneys, causing reabsorption of water into the body. This reabsorption in turn decreases night-time urine production. Due to the proposed low gender-specific doses (25 micrograms for females and 50 micrograms for males), and the limited duration of action of NOCDURNA, the antidiuretic activity is limited to the night time sleep period. Pharmacodynamic effects In study CS29, the weight-corrected NOCDURNA dose that induced 50% maximum achievable drug effect on nocturnal urine volume differed significantly between females and
NAME OF THE MEDICINE NOCDURNA® sublingual wafers Desmopressin Synonyms of desmopressin: DDAVP 1-Desamino-8-D-Arginine vasopressin. Desamino-cys-1-D-Arginine-8-vasopressin. CAS Nos.: Desmopressin base 16679-58-6 Desmopressin acetate 62288-83-9 Molecular formula and molecular mass: C48H74N14O17S2 (acetate trihydrate) MW = 1183.2 C46H64N14O12S2 (free base) MW = 1069.2 Physical and chemical characteristics: A white, fluffy powder, soluble in water, in alcohol and in glacial acetic acid. DESCRIPTION NOCDURNA, a sublingual wafer, contains the active substance, desmopressin (present as the hydrated acetate), a synthetic structural analogue of the natural pituitary hormone, arginine vasopressin. The difference lies in the desamination of cysteine and substitution of L-arginine by D-arginine. NOCDURNA also contains gelatin, mannitol and citric acid. PHARMACOLOGY Pharmacodynamics Pharmacotherapeutic group: Vasopressin and analogues. ATC code: H01B A02 Mechanism of action NOCDURNA contains desmopressin, a synthetic analogue of naturally occurring anti-diuretic hormone arginine vasopressin (AVP). Desmopressin mimics vasopressin’s anti-diuretic effect, binding to the V2 receptors in the renal collecting tubules of the kidneys, causing reabsorption of water into the body. This reabsorption in turn decreases night-time urine production. Due to the proposed low gender-specific doses (25 micrograms for females and 50 micrograms for males), and the limited duration of action of NOCDURNA, the antidiuretic activity is limited to the night time sleep period. Pharmacodynamic effects In study CS29, the weight-corrected NOCDURNA dose that induced 50% maximum achievable drug effect on nocturnal urine volume differed significantly between females and
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