Table SI 2. LC-MS/MS parameters LC: Nexcera (Shimadzu Co. Ltd., Mobile Phase Pump A Deionized water Pump B Methanol 0.1% NH4OH in Pre-clean Pump C Methanol Pump D Deionized water Ternary Gradient (A/B/C Flow rate 0.25 mL/min Pump) Sample Loading (D Pump) 1 mL/min Column Scrubber column (Pump A) HLB 2.1 x 20 mm Scrubber column (Pump B) OASIS WAX 2.1 x 20 mm Scrubber column (Pump C) Ghost Trap DS 7.6 x 30 mm Scrubber column (Pump D) OASIS HLB 2.1 x 20 mm Pre-concentration column WAX 2.1 x 20 mm Analytical column Inertsustain C18 2.1 x 50 mm Auto sampler Injection Volume 3 mL MS: LCMS-8080 (Shimadzu Co. Ltd., Interface Interface HV - 4.5 kV Parameter Probe Temperature 300 °C HSID Temperature 200 °C Nebulizer Gas (Air) 2 L/min Heating Gas (Air) 12 L/min Curtain Gas (N2) 3 L/min Exhaust Gas ON
Table SI 2. LC-MS/MS parameters LC: Nexcera (Shimadzu Co. Ltd., Mobile Phase Pump A Deionized water Pump B Methanol Pump C 0.1% NH4OH in Pre-clean Methanol Pump D Deionized water Flow rate Ternary Gradient (A/B/C Pump) 0.25 mL/min Sample Loading (D Pump) 1 mL/min Column Scrubber column (Pump A) HLB 2.1 x 20 mm Scrubber column (Pump B) OASIS WAX 2.1 x 20 mm Scrubber column (Pump C) Ghost Trap DS 7.6 x 30 mm Scrubber column (Pump D) OASIS HLB 2.1 x 20 mm Pre-concentration column WAX 2.1 x 20 mm Analytical column Inertsustain C18 2.1 x 50 mm Auto sampler Injection Volume 3 mL MS: LCMS-8080 (Shimadzu Co. Ltd., Interface Parameter Interface HV - 4.5 kV Probe Temperature 300 °C HSID Temperature 200 °C Nebulizer Gas (Air) 2 L/min Heating Gas (Air) 12 L/min Curtain Gas (N2) 3 L/min Exhaust Gas ON
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