Drug Renal and hepatic function Side effects Advice for patients Other info Atorvastatin Renal function: Myalgia Can be taken any time of Choice of statin as per NICE (10mg to 80mg Initially 20mg a day in CKD, increased if Sleep disturbance the day guidance a day) necessary (on specialist advice if eGFR < Hyperglycaemia If taking at night and Beware of drug interaction 30ml/min/1.73m²); max 80mg a day Hepatitis problem with sleep, change such as antibiotics, Hepatic function: GI problems to morning antifungals, etc Caution in pts with history of liver Report unexplained muscle disease pain, tenderness or Avoid in active liver disease, discontinue weakness to GPs if transaminases of more than 3x upper Not more than one or two limit small glasses of grapefruit juice a day Simvastatin Renal function: Same as atorvastatin Take at night Beware of drug interaction (10mg to 80mg Doses >10mg a day should be used with Report unexplained muscle such as antibiotics, at night) caution if eGFR < 30ml/min/1.73m² pain, tenderness or antifungals, calcium channel Hepatic function: weakness to GPs blockers, etc Same as atorvastatin Avoid grapefruit juice
Drug Renal and hepatic function Side effects Advice for patients Other info Atorvastatin (10mg to 80mg a day) Renal function: Initially 20mg a day in CKD, increased if necessary (on specialist advice if eGFR < 30ml/min/1.73m²); max 80mg a day Hepatic function: Caution in pts with history of liver disease Avoid in active liver disease, discontinue if transaminases of more than 3x upper limit Myalgia Sleep disturbance Hyperglycaemia Hepatitis GI problems Can be taken any time of the day If taking at night and problem with sleep, change to morning Report unexplained muscle pain, tenderness or weakness to GPs Not more than one or two small glasses of grapefruit juice a day Choice of statin as per NICE guidance Beware of drug interaction such as antibiotics, antifungals, etc Simvastatin (10mg to 80mg at night) Renal function: Doses >10mg a day should be used with caution if eGFR < 30ml/min/1.73m² Hepatic function: Same as atorvastatin Same as atorvastatin Take at night Report unexplained muscle pain, tenderness or weakness to GPs Avoid grapefruit juice Beware of drug interaction such as antibiotics, antifungals, calcium channel blockers, etc
Anti-diabetic-drugs-and-statins-NMS-and-MUR.docx