Agonist Receptor % Inhibition in Conc. Gefitinib activity ± SEM Methoxamine 0.001μM -3.82 ± 0.31 α1-adrenergic receptor agonist 0.01μM 0.82 ± 0.19 0.1μM -5.6 ± 0.60 1μM -5.34 ± 0.31 10μM -5.13 ± 0.44 Clonidine adrenergic -3.97 ± 0.16 α2 receptor agonist 0.01μM -9.24 ± 0.07 0.1μM -2.86 ± 0.06 1μM -5.03 ± 0.47 10μM -2.27 ± 0.14 Carbachol Muscarinic 0.00001μM -0.75 ± 0.32 acetylcholine 0.0001μM -11.12 ± 0.10 receptor agonist 0.001μM -4.19 ± 0.65 0.01μM -4.69 ± 0.74 0.1μM -7.48 ± 0.18 1μM 16.56 ± 2.89 10μM 26.44 ± 0.61 Serotonin 5 0.001μM 0.36 ± 0.27 0.01μM -11.59 ± 0.96 0.1μM -9.59 ± 0.52 1μM -6.63 ± 0.36 10μM -7.15 ± 0.48 I-TAC CXCR3 -0.67 ± 0.19 1.01 ± 0.27 -4.79 ± 0.20 SDF-1 CXCR4 -6.49 ± 0.89 -16.74 ± 0.80 -9.66 ± 0.28 IL8 CCR, CXCR -1.96 ± 0.02 -1.53 ± 0.09 -2.84 ± 0.04 -3.27 ± 0.02 -4.38 ± 0.00 -9.63 ± 0.11
Agonist Receptor Conc. % Inhibition in Gefitinib activity ± SEM Methoxamine α1-adrenergic receptor agonist 0.001μM 0.01μM 0.1μM 1μM 10μM -3.82 ± 0.31 0.82 ± 0.19 -5.6 ± 0.60 -5.34 ± 0.31 -5.13 ± 0.44 Clonidine α2 adrenergic receptor agonist 0.01μM 0.1μM 1μM 10μM -3.97 ± 0.16 -9.24 ± 0.07 -2.86 ± 0.06 -5.03 ± 0.47 -2.27 ± 0.14 Carbachol Muscarinic acetylcholine receptor agonist 0.00001μM 0.0001μM 0.001μM 0.01μM 0.1μM 1μM 10μM -0.75 ± 0.32 -11.12 ± 0.10 -4.19 ± 0.65 -4.69 ± 0.74 -7.48 ± 0.18 16.56 ± 2.89 26.44 ± 0.61 Serotonin 5 0.001μM 0.01μM 0.1μM 1μM 10μM 0.36 ± 0.27 -11.59 ± 0.96 -9.59 ± 0.52 -6.63 ± 0.36 -7.15 ± 0.48 I-TAC CXCR3 -0.67 ± 0.19 1.01 ± 0.27 -4.79 ± 0.20 SDF-1 CXCR4 -6.49 ± 0.89 -16.74 ± 0.80 -9.66 ± 0.28 IL8 CCR, CXCR -1.96 ± 0.02 -1.53 ± 0.09 -2.84 ± 0.04 -3.27 ± 0.02 -4.38 ± 0.00 -9.63 ± 0.11
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