Embryofetal 1 3 0.9 2 6 1.8 [Esaki et al. (1980)] GD15–PND20 0.5 1.5 0.4 1 3 0.9 and 2 6 1.8 Hirayama (1979b)] Rat Fertility = 80 days 8 48 14 ♂ (RAC) [FDA report (mated with on Tenex] untreated 16 96 29 females); = 12 ♀ days + GD0–GD5 (mated with untreated males) Rat Embryofetal GD6–GD15 1 6 1.8 (OFA) 3 18 5.4 [FDA report on Tenex] 10 60 18 Rat GD15–PND21 2 12 3.6 (RAC) 4 24 7.2 [FDA report 8 48 14 on Tenex] Rabbit Embryofetal GD6–GD18 0.5 7.5 2.2 (‘hare-type’ (presumably 1 15 4.5 Belgian hare [FDA report variety)) on Tenex] 5 75 22 Rabbit Embryofetal GD6–GD18 0.5 7.5 2.2 (NZW) 1 15 4.5 [Esaki and 2 30 9.0 Nakayama (1979)] Human steady state [4 mg] 3.3^ – – ADHD [Clinical patients (♂ + Study
Embryofetal [Esaki et al. (1980)] 1 3 0.9 2 6 1.8 and Hirayama (1979b)] GD15–PND20 0.5 1.5 0.4 1 3 0.9 2 6 1.8 Rat (RAC) Fertility [FDA report on Tenex] ♂ = 80 days (mated with untreated females); ♀ = 12 days + GD0–GD5 (mated with untreated males) 8 48 14 16 96 29 Rat (OFA) Embryofetal [FDA report on Tenex] GD6–GD15 1 6 1.8 3 18 5.4 10 60 18 Rat (RAC) [FDA report on Tenex] GD15–PND21 2 12 3.6 4 24 7.2 8 48 14 Rabbit (‘hare-type’ (presumably Belgian hare variety)) Embryofetal [FDA report on Tenex] GD6–GD18 0.5 7.5 2.2 1 15 4.5 5 75 22 Rabbit (NZW) Embryofetal [Esaki and Nakayama (1979)] GD6–GD18 0.5 7.5 2.2 1 15 4.5 2 30 9.0 Human ADHD patients (♂ + steady state [Clinical Study – [4 mg] 3.3^ –
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