We also detected some effects in MCI subtypes such Delayed Recall (β=-0.36, for (see Table 3.B) and, Learning (β=-1.37, p=5.815E-05) for Pss-aMCI (see Table 3.C). Table 3. Major results of AD loci linked to in MCI endophenotypes by clinical APOE subtypes. Endophenotypes N Locus/ snp L95 U95 p-value β 3.A MCI Total sample -1.35 -1.95 -0.76 2.914E-06* Learning 1243 APOE-ε4 1243 -0.76 -1.00 -0.51 4.095E-10* APOE-ε4 Delayed Recall 1137 -0.64 -0.92 -0.34 9.159E-06* TOMM40-rs2075650 Recognition 1243 -0.58 -0.88 -0.27 9.665E-05* APOE-ε4 3.B aMCI Learning 1243 -0.80 -1.37 -0.23 0.00427 APOE-ε4 Delayed Recall 1243 -0.36 -0.53 -0.18 2.959E-05* APOE-ε4 Recognition 1243 -0.36 -0.71 -0.02 0.029 APOE-ε4 3.C Pss-aMCI Learning 1243 -1.37 -2.07 -0.68 5.815E-05* APOE-ε4 Delayed Recall 1243 -0.36 -0.59 -0.12 0.0018 APOE-ε4 Recognition 1243 -0.43 -0.85 -0.02 0.0314 APOE-ε4 Beta; L-U95: confidence intervals 95% ; *Statistically significant after Bonferroni’s correction (p≤ β: 10-E-5).
We also detected some effects in MCI subtypes such Delayed Recall (β=-0.36, for (see Table 3.B) and, Learning (β=-1.37, p=5.815E-05) for Pss-aMCI (see Table 3.C). Table 3. Major results of AD loci linked to APOE in MCI endophenotypes by clinical subtypes. Endophenotypes N Locus/ snp β L95 U95 p-value 3.A MCI Total sample Learning 1243 APOE-ε4 -1.35 -1.95 -0.76 2.914E-06* Delayed Recall 1243 APOE-ε4 -0.76 -1.00 -0.51 4.095E-10* 1137 TOMM40-rs2075650 -0.64 -0.92 -0.34 9.159E-06* Recognition 1243 APOE-ε4 -0.58 -0.88 -0.27 9.665E-05* 3.B aMCI Learning 1243 APOE-ε4 -0.80 -1.37 -0.23 0.00427 Delayed Recall 1243 APOE-ε4 -0.36 -0.53 -0.18 2.959E-05* Recognition 1243 APOE-ε4 -0.36 -0.71 -0.02 0.029 3.C Pss-aMCI Learning 1243 APOE-ε4 -1.37 -2.07 -0.68 5.815E-05* Delayed Recall 1243 APOE-ε4 -0.36 -0.59 -0.12 0.0018 Recognition 1243 APOE-ε4 -0.43 -0.85 -0.02 0.0314 β: Beta; L-U95: confidence intervals 95% ; *Statistically significant after Bonferroni’s correction (p≤ 10-E-5).
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