Table 13. Difference from Sham, BCVA (letters) mean change from baseline (AUC) Study / pre specified subgroup 700 µg 350 µg versus Sham versus Sham 010 Any prior treatment N (Sham N=127) 123 126 difference from Sham (p value) 2.6 (0.011) 3.2 (0.002) Pseudophakic eye at baseline N (Sham N=50) 44 47 difference from Sham (p value) 5.9 (<0.001) 4.1 (0.007) 011 Any prior treatment N (Sham N=134) 124 123 difference from Sham (p value) 0.7 (0.495) 0.8 (0.409) Pseudophakic eye at baseline N (Sham N=51) 42 41 difference from Sham (p value) 3.6 (0.018) 4.3 (0.005) Percentage of patients with 15+ letter improvement in BCVA, difference from Sham are shown in Table 14. Table 14. Percentage of patients with 15+ letter improvement in BCVA, difference from Sham 700 µg versus 350 µg versus Sham Sham 010 Any prior treatment N (Sham N=127) 123 126 difference from Sham (p 11% (0.020) 10% (0.036) Pseudophakic eye at baseline N (Sham N=50) 44 47 difference from Sham (p value) 18% (0.042) -1% (0.880) 011 Any treatment N (Sham N=134) 124 123 difference from Sham (p value) 10% (0.032) 3% (0.410)
Table 13. Difference from Sham, BCVA (letters) mean change from baseline (AUC) Study / pre specified subgroup 700 µg versus Sham 350 µg versus Sham 010 Any prior treatment N (Sham N=127) difference from Sham (p value) 123 2.6 (0.011) 126 3.2 (0.002) Pseudophakic eye at baseline N (Sham N=50) difference from Sham (p value) 44 5.9 (<0.001) 47 4.1 (0.007) 011 Any prior treatment N (Sham N=134) difference from Sham (p value) 124 0.7 (0.495) 123 0.8 (0.409) Pseudophakic eye at baseline N (Sham N=51) difference from Sham (p value) 42 3.6 (0.018) 41 4.3 (0.005) Percentage of patients with 15+ letter improvement in BCVA, difference from Sham are shown in Table 14. Table 14. Percentage of patients with 15+ letter improvement in BCVA, difference from Sham 700 µg versus Sham 350 µg versus Sham 010 Any prior treatment N (Sham N=127) difference from Sham (p 123 11% (0.020) 126 10% (0.036) Pseudophakic eye at baseline N (Sham N=50) difference from Sham (p value) 44 18% (0.042) 47 -1% (0.880) 011 Any treatment N (Sham N=134) difference from Sham (p value) 124 10% (0.032) 123 3% (0.410)
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