Alzheimer’s cognitive level with controls disease Serum TFA (% total P=0.0029 FA): C18:1 (n-7) vaccenic Controls: 1.96±0.3 2.26±0.4 C18:1 (n-9)t elaidic Controls: 0.04±0.02 Cases: 0.04±0.03 C18:2 (n-9)t linoleadic Controls: 0.04±0.02 0.04±0.01 () No TFA data Country: Sweden Dietary Age, gender, 12 R’ship b/t Intake: +ve assoc. in Margarine N=1014, 51% F assessment: dietary variables consumption of those consuming Cross-sectional consumption Age: Median 9 (5-14) y TFA not assessed. (meat, fish, margarine, respiratory margarine b/t: 114 subjects reported 7 question dietary fruits, veg, fresh symptoms and asthma respiratory symptoms, Asthma and allergy intolerance questionnaire milk, fermented OR (95% CI): asthma and allergens. allergy in administered. milk, fast food, Wheeze: 0.68 relation to TFA intake not Measured butter, diet measured consumption of margarine, olive Daytime meat, fish, fruits, oil, rapeseed oil, breathlessness: 1.23 Margarine intake: veg, fresh milk, PUFA) (0.51-2.96) Consumption yes/no fermented milk Current asthma: 0.79 No=19% and fast food. (0.37-1.68) Yes=81 Q’airre contained Atopic sensitisation: yes/no questions 0.86 (0.52-1.42) on 5 types of fat. With regards to Outcome dx: allergens: Current asthma Among those assessed as consuming margarine, current there were significant medication or positive associations attack in past 12 (P<0.05) between months. wheeze and dog and Additional horse allergen levels,
Alzheimer’s disease Serum TFA (% total FA): C18:1 (n-7) vaccenic Controls: 1.96±0.3 2.26±0.4 C18:1 (n-9)t elaidic Controls: 0.04±0.02 Cases: 0.04±0.03 C18:2 (n-9)t linoleadic Controls: 0.04±0.02 0.04±0.01 cognitive level with controls P=0.0029 () Cross-sectional No TFA data Margarine consumption Asthma and allergy in relation to diet Country: Sweden N=1014, 51% F Age: Median 9 (5-14) y 114 subjects reported allergy intolerance TFA intake not measured Margarine intake: Consumption yes/no No=19% Yes=81 Dietary assessment: TFA not assessed. 7 question dietary questionnaire administered. Measured consumption of meat, fish, fruits, veg, fresh milk, fermented milk and fast food. Q’airre contained yes/no questions on 5 types of fat. Outcome dx: Current asthma assessed as current medication or attack in past 12 months. Additional Age, gender, 12 dietary variables (meat, fish, fruits, veg, fresh milk, fermented milk, fast food, butter, margarine, olive oil, rapeseed oil, PUFA) R’ship b/t consumption of margarine, respiratory symptoms and asthma OR (95% CI): Wheeze: 0.68 Daytime breathlessness: 1.23 (0.51-2.96) Current asthma: 0.79 (0.37-1.68) Atopic sensitisation: 0.86 (0.52-1.42) With regards to allergens: Among those consuming margarine, there were significant positive associations (P<0.05) between wheeze and dog and horse allergen levels, Intake: +ve assoc. in those consuming margarine b/t: respiratory symptoms, asthma and allergens.
Appendix%201%20to%20SD4%20Summary%20of%20reviewed%20literature%20examining%20TFA%20and%20health%20outcomes.docx