peripheral arterial occlusive disease, peripheral ischaemia, peripheral Common artery stenosis, intermittent claudication, deep vein thrombosis, hot flush, flushing poor peripheral circulation, splenic Uncommon infarction, embolism venous, venous thrombosis Very common dyspnoea, Respiratory, thoracic and pulmonary embolism, pleural mediastinal disorders Common effusion, epistaxis, dysphonia, pulmonary hypertension abdominal pain, diarrhoea, vomiting, Very common constipation, nausea, lipase increased pancreatitis, blood amylase increased, gastrooesophageal reflux Gastrointestinal disorders Common disease, stomatitis, dyspepsia, abdominal distension, abdominal discomfort, dry mouth Uncommon gastric haemorrhage alanine aminotransferase increased, Very common aspartate aminotransferase increased blood bilirubin increased, blood Hepatobiliary disorders alkaline phosphatase increased, Common gamma-glutamyltransferase increased Uncommon hepatotoxicity, jaundice Very common rash, dry skin rash pruritic, exfoliative rash, Skin and subcutaneous erythema, alopecia, pruritis, skin tissue disorders Common exfoliation, night sweats, hyperhidrosis, petechia, ecchymosis, pain of skin, dermatitis exfoliative bone pain, arthralgia, myalgia, pain in Very common Musculoskeletal and extremity, back pain, muscle spasms connective tissue musculoskeletal pain, neck pain, disorders Common musculoskeletal chest pain Reproductive system and Common erectile dysfunction breast disorders
Common peripheral arterial occlusive disease, peripheral ischaemia, peripheral artery stenosis, intermittent claudication, deep vein thrombosis, hot flush, flushing Uncommon poor peripheral circulation, splenic infarction, embolism venous, venous thrombosis Respiratory, thoracic and mediastinal disorders Very common dyspnoea, Common pulmonary embolism, pleural effusion, epistaxis, dysphonia, pulmonary hypertension Gastrointestinal disorders Very common abdominal pain, diarrhoea, vomiting, constipation, nausea, lipase increased Common pancreatitis, blood amylase increased, gastrooesophageal reflux disease, stomatitis, dyspepsia, abdominal distension, abdominal discomfort, dry mouth Uncommon gastric haemorrhage Hepatobiliary disorders Very common alanine aminotransferase increased, aspartate aminotransferase increased Common blood bilirubin increased, blood alkaline phosphatase increased, gamma-glutamyltransferase increased Uncommon hepatotoxicity, jaundice Skin and subcutaneous tissue disorders Very common rash, dry skin Common rash pruritic, exfoliative rash, erythema, alopecia, pruritis, skin exfoliation, night sweats, hyperhidrosis, petechia, ecchymosis, pain of skin, dermatitis exfoliative Musculoskeletal and connective tissue disorders Very common bone pain, arthralgia, myalgia, pain in extremity, back pain, muscle spasms Common musculoskeletal pain, neck pain, musculoskeletal chest pain Reproductive system and breast disorders Common erectile dysfunction
auspar-ponatinib-20150416-pi.docx