GEC-ESTRO ACROP recommendations in skin brachytherapy Supplementary tables and figures Supplementary tables 3: Main series with customized moulds and flaps. AUTHOR/ # DOSE FREQUENCY BED LOCAL ACUTE CHRONIC TOXICITY YEAR (FR) DOSE (Gy) UP # patients/ # months lesions G 3 ≥ Svoboda V et Customized 1-15 4-22 Surface 12-50 Single/ 9.6 96.3% ----- ----- Mixed al. [14] moulds Gy of the Gy (mean) 1995 a day/ 76p/106 or Daily Somanchi BV Customized 8 5- 80% 40-45 5 days 60 100% ----- Mild atrophy 28% Skin et al. [62] moulds 5.6 Gy 1 Monday Mild telangiectasias hand 2008 Gy 1.5- and Friday 48% 25 p 3.5mm and 2 the Mild alopecia 28% other days Necrosis Amputation 4% Maroñas M et Customized 11-12 4 Gy 3mm 44-48 3 times 45 90.2% 21% 0% al. [19] moulds from Gy week good/ 2011 skin 100% 48p/51 18 3Gy surface 70.2 54Gy Amendola B et Customized 10 ------ 48.5-50 2 times 56-75 85 95% ----- ---- al. [15] moulds Gy Gy week good 2016 28p/42 Chan A et al. Fleiburg flap 5 12 5 mm 60 Gy Weekly 132 14.2 90.4% ----- ----- 2003 Gy from 25p/36 app. (unpublished) surface Kanikowski M Fleiburg flap 10 5-6 10 mm 50-60 ------ 75-96 12 71.6% 8,9% 24.4% Mixed et al. 2009 Gy from Gy 2016 6-8 source 30-40 45-60 4,9 G3 Radical 497p Gy (unpublished) BED - biological effective dose Table 4: Results with Leipzig and Valencia applicators
GEC-ESTRO ACROP recommendations in skin brachytherapy Supplementary tables and figures Supplementary tables 3: Main series with customized moulds and flaps. AUTHOR/ YEAR # patients/ # lesions # DOSE (FR) DOSE FREQUENCY BED (Gy) UP months LOCAL ACUTE G ≥ 3 CHRONIC TOXICITY Svoboda V et al. [14] 1995 76p/106 Customized moulds 1-15 4-22 Gy Surface of the 12-50 Gy Single/ a day/ Daily 9.6 (mean) 96.3% ----- ----- Mixed Somanchi BV et al. [62] 2008 25 p Customized moulds 8 5- 5.6 Gy 80% 1.5- 3.5mm 40-45 Gy 5 days 1 Monday and Friday and 2 the other days 60 100% ----- Mild atrophy 28% Mild telangiectasias 48% Mild alopecia 28% Necrosis Amputation 4% Skin hand Maroñas M et al. [19] 2011 48p/51 Customized moulds 11-12 18 4 Gy 3Gy 3mm from skin surface 44-48 Gy 54Gy 3 times week 70.2 45 90.2% 21% 0% good/ 100% Amendola B et al. [15] 2016 28p/42 Customized moulds 10 Gy ------ 48.5-50 Gy 2 times week 56-75 85 95% ----- ---- good Chan A et al. 2003 25p/36 (unpublished) Fleiburg flap 5 12 Gy 5 mm from app. surface 60 Gy Weekly 132 14.2 90.4% ----- ----- Kanikowski M et al. 2009 2016 497p (unpublished) Fleiburg flap 10 6-8 5-6 Gy 10 mm from source 50-60 Gy or 30-40 Gy ------ 75-96 45-60 12 71.6% 8,9% 24.4% 4,9 G3 Mixed Radical BED - biological effective dose Table 4: Results with Leipzig and Valencia applicators
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