Bornavirus Introduction The family of Bornaviridae consisted of only bornavirus. Bornavirus is under its own family due to its unique replication process - a RNA virus that replications in the nucleus. Currently, bornavirus is the only known animal RNA virus that can replicate in the nucleus. Bornavirus often infect the central, peripheral and autonomic nervous system causing neuropsychiatric disorders in humans and animals. Structure and replication Bornavirus (BDV) is enveloped, non-segmented, negative sense RNA. Its genome is about 8.9 kb long. The BDV can encode at least six proteins, however, the main structural proteins include nucleoprotein (N), phosphoprotein (P), matrix protein (M), envelope glycoprotein (G) and RNA-dependent polymerase (L). The BDV enter the host cell through endocytosis. Studies showed that only glycoprotein 84 was found in infected cells, thus, it was assumed being used as a receptor that the BDV binds to. Fusion of the virus to cell membrane is pH dependent requiring more acidic environment. Once in the cell, BDV is taken up by endosomes and will be transported to the nucleus where its genome will be released. In the nucleus, BDV will replicate to produce viral particles. However, the exact replication of BDV is still unclear. bornavirus (ABV) It is not recently, ABV being identified as the causative agent of proventricular dilatation disease (PDD) in psittacine birds, a fatal disease. PDD
Bornavirus Introduction The family of Bornaviridae consisted of only bornavirus. Bornavirus is under its own family due to its unique replication process - a RNA virus that replications in the nucleus. Currently, bornavirus is the only known animal RNA virus that can replicate in the nucleus. Bornavirus often infect the central, peripheral and autonomic nervous system causing neuropsychiatric disorders in humans and animals. Structure and replication Bornavirus (BDV) is enveloped, non-segmented, negative sense RNA. Its genome is about 8.9 kb long. The BDV can encode at least six proteins, however, the main structural proteins include nucleoprotein (N), phosphoprotein (P), matrix protein (M), envelope glycoprotein (G) and RNA-dependent polymerase (L). The BDV enter the host cell through endocytosis. Studies showed that only glycoprotein 84 was found in infected cells, thus, it was assumed being used as a receptor that the BDV binds to. Fusion of the virus to cell membrane is pH dependent requiring more acidic environment. Once in the cell, BDV is taken up by endosomes and will be transported to the nucleus where its genome will be released. In the nucleus, BDV will replicate to produce viral particles. However, the exact replication of BDV is still unclear. bornavirus (ABV) It is not recently, ABV being identified as the causative agent of proventricular dilatation disease (PDD) in psittacine birds, a fatal disease. PDD
Alice_Chow_Bornavirus.docx