Hoffman et al. 0.72 0.36 20/20/18 4 ARA levels supported. Quality Appropriate – (2000) DHA+ARA maintained ARA levels outcomes, outcomes reliably comparable to BF infants and measured. DB RCT significantly higher than C Limitations Limited description – (P<.05). of selection and allocation procedures described; disposition of subjects not provided; no power calculation provided. Overall limited quality – Makrides et al. 0.34 0.34 33/21/21 12 ARA levels supported. Quality - selection and (1999) At 34 and 52 wk DHA+ARA same allocation procedures as BF and significantly higher described; disposition of DB RCT ARA than C or DHA-alone subjects provided; appropriate (P<.01). outcomes, outcomes reliably measured. Limitations Groups differed – somewhat at baseline; Dropout rate 18%; statistical power limited, i.e. n=25 per group required, n=21 completed. Overall limited quality –
Hoffman et al. (2000) DB RCT 0.72 0.36 20/20/18 4 ARA levels supported. DHA+ARA maintained ARA levels comparable to BF infants and significantly higher than C (P<.05). Quality – Appropriate outcomes, outcomes reliably measured. Limitations – Limited description of selection and allocation procedures described; disposition of subjects not provided; no power calculation provided. Overall – limited quality Makrides et al. (1999) DB RCT 0.34 0.34 33/21/21 12 ARA levels supported. At 34 and 52 wk DHA+ARA same as BF and significantly higher ARA than C or DHA-alone (P<.01). Quality - selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured. Limitations – Groups differed somewhat at baseline; Dropout rate 18%; statistical power limited, i.e. n=25 per group required, n=21 completed. Overall – limited quality
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