Appendix 1 Table A1: Randomised Controlled Trials with DHA from various sources (and ARA) Reporting Growth Outcomes Study/Study ARA DHA Age at Outcome Summary Study Quality and Limitations Number of Design (%FA) (%FA) Start/Duration of Subjects at Supplementation longest duration (BF/C/DHA) DHA+ARA) Auestad et al. 0.43 0.12 63/45/46 ~ 7 days/12 mo No difference in Quality - Groups comparable at (1997) (2003) growth outcomes baseline; selection and allocation (weight, length, head procedures described; disposition DB RCT circumference) of subjects provided; appropriate between groups outcomes, outcomes reliably No difference in measured. growth between Limitations high drop-out rate – groups 27 mo (23%); limited follow-up (80%) at post- 27 mo post supplementation; supplementation sufficient statistical power not verified (i.e. no power calculation provided) Overall moderate quality – Auestad et al. 0.45 0.14 82/77/162 ~9 days/12 mo No difference in Quality - Groups comparable at (2001) growth (weight, baseline; selection and allocation length, head procedures described; disposition DB RCT circumference) of subjects provided; appropriate between groups outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations high drop-out rate – (27%) Overall moderate-high quality –
Appendix 1 Table A1: Randomised Controlled Trials with DHA from various sources (and ARA) Reporting Growth Outcomes Study/Study Design ARA (%FA) DHA (%FA) Number of Subjects at longest duration (BF/C/DHA) DHA+ARA) Age at Start/Duration of Supplementation Outcome Summary Study Quality and Limitations Auestad et al. (1997) (2003) DB RCT 0.43 0.12 63/45/46 ~ 7 days/12 mo No difference in growth outcomes (weight, length, head circumference) between groups No difference in growth between groups 27 mo post- supplementation Quality - Groups comparable at baseline; selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured. Limitations – high drop-out rate (23%); limited follow-up (80%) at 27 mo post supplementation; sufficient statistical power not verified (i.e. no power calculation provided) Overall – moderate quality Auestad et al. (2001) DB RCT 0.45 0.14 82/77/162 ~9 days/12 mo No difference in growth (weight, length, head circumference) between groups Quality - Groups comparable at baseline; selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations – high drop-out rate (27%) Overall – moderate-high quality
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