The patients exhibited substantial interindividual variability in the lung mechanical and capnographic parameters (Table 1S), as reflected in the high coefficient of variation values before, after and the differences between after and before values. Before After After-Before CPB Raw 116 98 109 G 69 127 227 H 41 44 262 SnII,T 36 33 1163 SnIII,T 169 96 113 VDF 26 24 -134 VDB 25 24 -138 VDE 28 32 156 50 45 114 Table 1S. Coefficients of variations for the lung mechanical (Raw, G and H) and capnographic parameters (SnII,T, SnIII,T, VDF, VDB, VDE, VDE-VDB). The key parameters obtained by forced oscillations and capnography for the individual patients are demonstrated on Fig. 1S (continuous thin lines), and for the group means (symbols with thick lines). Based on their starting pulmonary function, the cohort was divided into 3 groups: patients with the highest 25% (red), the medium 50% (grey) and the lowest 25% HQ (green). There was no evidence for a statistical significance between the groups in the lung mechanical parameters (Raw, G and H) and capnographic shape factors (SnII,T and SnIII,T). This can be attributed to the complex pathophysiological processes involved in the gas exchange, including ventilation, perfusion and ventilation/perfusion. Accordingly, there is no direct link between individual lung mechanical or capnogram parameters with gas exchange indices. Conversely, capnographic parameters primarily affected by lung perfusion (VDF, VDB, VDE and VDE-VDB) exhibit statistically significant differences in the different HQ groups.
The patients exhibited substantial interindividual variability in the lung mechanical and capnographic parameters (Table 1S), as reflected in the high coefficient of variation values before, after and the differences between after and before values. Before After After-Before CPB Raw 116 98 109 G 69 127 227 H 41 44 262 SnII,T 36 33 1163 SnIII,T 169 96 113 VDF 26 24 -134 VDB 25 24 -138 VDE 28 32 156 50 45 114 Table 1S. Coefficients of variations for the lung mechanical (Raw, G and H) and capnographic parameters (SnII,T, SnIII,T, VDF, VDB, VDE, VDE-VDB). The key parameters obtained by forced oscillations and capnography for the individual patients are demonstrated on Fig. 1S (continuous thin lines), and for the group means (symbols with thick lines). Based on their starting pulmonary function, the cohort was divided into 3 groups: patients with the highest 25% (red), the medium 50% (grey) and the lowest 25% HQ (green). There was no evidence for a statistical significance between the groups in the lung mechanical parameters (Raw, G and H) and capnographic shape factors (SnII,T and SnIII,T). This can be attributed to the complex pathophysiological processes involved in the gas exchange, including ventilation, perfusion and ventilation/perfusion. Accordingly, there is no direct link between individual lung mechanical or capnogram parameters with gas exchange indices. Conversely, capnographic parameters primarily affected by lung perfusion (VDF, VDB, VDE and VDE-VDB) exhibit statistically significant differences in the different HQ groups.
AA_2016_01_08_PETAK_AAJ-D-16-01059_SDC1.docx