CYSTIC FIBROSIS SPECIALITY GUIDELINES Assess previous sputum microbiology results (organisms isolated and their sensitivities) Patient group Most likely causal organisms First choice Must cover common pathogens including: Cefuroxime IV Staph. aureus + tobramycin IV H. influenzae Pseudomonas No previous Moraxella catarrhalis aeruginosa See below if Pseudomonas aeruginosa isolated. As well as possible first isolate (especially young infants) of: Pseudomonas aeruginosa Pseudomonas aeruginosa Ceftazidime IV H. influenzae + tobramycin IV Moraxella catarrhalis (unless previous sensitivities suggest otherwise) Previous or proven current infection with isolated within previous 12 months and patient NOT Staph. aureus Ceftazidime IV Pseudomonas aeruginosa on long-term azithromycin + tobramycin IV + flucloxacillin PO (or Staph. aureus reported erythromycin-resistant)
CYSTIC FIBROSIS SPECIALITY GUIDELINES Assess previous sputum microbiology results (organisms isolated and their sensitivities) Patient group Most likely causal organisms First choice No previous Pseudomonas aeruginosa Must cover common pathogens including: Staph. aureus H. influenzae Moraxella catarrhalis As well as possible first isolate (especially young infants) of: Pseudomonas aeruginosa Cefuroxime IV + tobramycin IV See below if Pseudomonas aeruginosa isolated. Previous or proven current infection with Pseudomonas aeruginosa Pseudomonas aeruginosa H. influenzae Moraxella catarrhalis Ceftazidime IV + tobramycin IV (unless previous sensitivities suggest otherwise) Staph. aureus isolated within previous 12 months and patient NOT on long-term azithromycin (or Staph. aureus reported erythromycin-resistant) Ceftazidime IV + tobramycin IV + flucloxacillin PO
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