Prevention of secondary case of meningococcal meningitis 0-11mo: 5mg/kg 12-hourly for 2 days. 1–18yr: 10mg/kg 12-hourly (max. 600mg/dose) for 2 days. <1mo: 16 mg/kg loading dose, then 8 mg/kg once daily, starting 24 hours after loading dose. Teicoplanin mg/kg 12-hourly for 3 doses, then ≥1mo:10 10 mg/kg once daily (max400 mg/dose) Tobramycin 1mo-1yr: 3mg/kg 8-hourly CF (nebuliser >1 yr-18yr: 7mg/kg once daily for non-CF patients solution not iv For 8-hourly dosing (inc. PCD patients) prep): 300mg 12- monitor levels 2hr CF only: hourly (alternate before and 1hr after the 1mo-1yr: 7mg/kg once daily months) 2nd dose and again on >1yr:10mg/kg once daily (may be switched to day 8. 3.3mg/kg 8-hourly bolus dosing for home). For once daily dosing monitor trough levels 18 hr after 1st dose and repeat on day 8. Target trough <1mg/L Prophylaxis: All ages: 2mg/kg once daily at night (max 100mg/dose) Trimethoprim Treatment: <1mo: Initially 3mg/kg for 1 dose, then 2mg/kg 12- hourly >1mo: 4mg/kg 12-hourly (max 200mg/dose) Treatment of herpes simplex or herpes zoster in immunocomprosed patients: 3mo - <12 yr: 20mg/kg 8-hourly (suspension will Valaciclovir need to be made up specially in hospital pharmacy) 1 gram 8-hourly ≥12yr:
Prevention of secondary case of meningococcal meningitis 0-11mo: 5mg/kg 12-hourly for 2 days. 1–18yr: 10mg/kg 12-hourly (max. 600mg/dose) for 2 days. Teicoplanin <1mo: 16 mg/kg loading dose, then 8 mg/kg once daily, starting 24 hours after loading dose. ≥1mo:10 mg/kg 12-hourly for 3 doses, then 10 mg/kg once daily (max400 mg/dose) Tobramycin For 8-hourly dosing monitor levels 2hr before and 1hr after the 2nd dose and again on day 8. For once daily dosing monitor trough levels 18 hr after 1st dose and repeat on day 8. Target trough <1mg/L 1mo-1yr: 3mg/kg 8-hourly >1 yr-18yr: 7mg/kg once daily for non-CF patients (inc. PCD patients) CF only: 1mo-1yr: 7mg/kg once daily >1yr:10mg/kg once daily (may be switched to 3.3mg/kg 8-hourly bolus dosing for home). CF (nebuliser solution not iv prep): 300mg 12- hourly (alternate months) Trimethoprim Prophylaxis: All ages: 2mg/kg once daily at night (max 100mg/dose) Treatment: <1mo: Initially 3mg/kg for 1 dose, then 2mg/kg 12- hourly >1mo: 4mg/kg 12-hourly (max 200mg/dose) Valaciclovir Treatment of herpes simplex or herpes zoster in immunocomprosed patients: 3mo - <12 yr: 20mg/kg 8-hourly (suspension will need to be made up specially in hospital pharmacy) ≥12yr: 1 gram 8-hourly
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