Clandinin et al. 0.64 0.32 76/62/117 14 days/~12 mo Feeding formulas with Quality - selection and allocation (2005)* DHA and ARA from procedures described; disposition algal and fungal oils of subjects provided; appropriate DB RCT resulted in enhanced outcomes, outcomes reliably growth, i.e. weight measured; adequate statistical and length power, large study population. significantly (P<.05) Limitations Groups differed – greater in response to somewhat at baseline; Drop-out DHA+ARA formula. rate 14% Overall moderate quality – Makrides et al. 0.34 0.34 33/21/21 5-7 days/12 mo No difference in Quality - selection and allocation (1999) growth (weight, procedures described; disposition length, head of subjects provided; appropriate DB RCT circumference) outcomes, outcomes reliably between groups measured. Limitations Groups differed – somewhat at baseline; Drop-out rate 18%; statistical power limited, i.e. n=25 per group required, n=21 completed. Overall limited quality – et al. 0.41- 0.15- 43/91/180 ~3 days/12 mo No difference in Quality - Groups comparable at O’Connor (2001)* 0.43 .0.27 growth (weight, baseline; selection and allocation length, head procedures described; disposition DB RCT circumference) of subjects provided; appropriate between groups outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations drop-out rate (20%) – Overall moderate-high quality –
Clandinin et al. (2005)* DB RCT 0.64 0.32 76/62/117 14 days/~12 mo Feeding formulas with DHA and ARA from algal and fungal oils resulted in enhanced growth, i.e. weight and length significantly (P<.05) greater in response to DHA+ARA formula. Quality - selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations – Groups differed somewhat at baseline; Drop-out rate 14% Overall – moderate quality Makrides et al. (1999) DB RCT 0.34 0.34 33/21/21 5-7 days/12 mo No difference in growth (weight, length, head circumference) between groups Quality - selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured. Limitations – Groups differed somewhat at baseline; Drop-out rate 18%; statistical power limited, i.e. n=25 per group required, n=21 completed. Overall – limited quality O’Connor et al. (2001)* DB RCT 0.41- 0.43 0.15- .0.27 43/91/180 ~3 days/12 mo No difference in growth (weight, length, head circumference) between groups Quality - Groups comparable at baseline; selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations – drop-out rate (20%) Overall – moderate-high quality
A1124%20DHA%20algal%20oil%20to%20infant%20formula%20products%20SD1.docx