Grottke O, Braunschweig T, Spronk HM, Esch S, Rieg AD, van Oerle R, ten Cate H, Fitzner C, Tolba R, Rossaint R. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood. 2011;118:1943-51. Supplemental table 1: Hemodynamic variables and lactate levels. Data are shown as mean ± standard deviation (SD). In each group, n=9 animals initially. *P<0.05 vs. control group; vs. TXA–FCH group; vs. PCC25 group. Between-group differences †P<0.05 ‡P<0.05 are presented hierarchically as follows: IDA and PCC50 (‡,†,*) PCC25 (†,*) TXA–FCH (*) control. Mean arterial Lactate Cardiac output pressure [l/min] [mmol/L] [mmHg] Control 1.8 ± 0.7 — — TXA–FCH 1.7 ± 0.9 — — Baseline PCC25 1.7 ± 0.5 — — PCC50 1.2 ± 0.3 — — IDA 1.8 ± 1.3 — — Control 62 ± 2 3.7 ± 0.3 2.3 ± 0.2 TXA–FCH 61 ± 5 3.9 ± 0.5 1.8 ± 0.5 After dabigatran PCC25 62 ± 4 4.0 ± 0.4 2.1 ± 0.7 PCC50 62 ± 3 4.0 ± 0.3 1.9 ± 0.6 IDA 61 ± 3 3.9 ± 0.3 2.5 ± 0.3 Control 41 ± 7 3.0 ± 0.5 2.4 ± 0.3 TXA–FCH 46 ± 8 3.3 ± 0.5 2.1 ± 0.4 12 min PCC25 42 ± 4 3.5 ± 0.6 2.2 ± 0.5 trauma PCC50 43 ± 8 3.0 ± 1.0 2.1 ± 0.5 IDA 42 ± 5 3.5 ± 0.7 2.7 ± 0.2
Grottke O, Braunschweig T, Spronk HM, Esch S, Rieg AD, van Oerle R, ten Cate H, Fitzner C, Tolba R, Rossaint R. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood. 2011;118:1943-51. Supplemental table 1: Hemodynamic variables and lactate levels. Data are shown as mean ± standard deviation (SD). In each group, n=9 animals initially. *P<0.05 vs. control group; †P<0.05 vs. TXA–FCH group; ‡P<0.05 vs. PCC25 group. Between-group differences are presented hierarchically as follows: IDA and PCC50 (‡,†,*) PCC25 (†,*) TXA–FCH (*) control. Mean arterial pressure [mmHg] Cardiac output [l/min] Lactate [mmol/L] Baseline Control TXA–FCH PCC25 PCC50 IDA — — — — — — — — — — 1.8 ± 0.7 1.7 ± 0.9 1.7 ± 0.5 1.2 ± 0.3 1.8 ± 1.3 After dabigatran Control TXA–FCH PCC25 PCC50 IDA 62 ± 2 61 ± 5 62 ± 4 62 ± 3 61 ± 3 3.7 ± 0.3 3.9 ± 0.5 4.0 ± 0.4 4.0 ± 0.3 3.9 ± 0.3 2.3 ± 0.2 1.8 ± 0.5 2.1 ± 0.7 1.9 ± 0.6 2.5 ± 0.3 12 min Control TXA–FCH PCC25 PCC50 IDA 41 ± 7 46 ± 8 42 ± 4 43 ± 8 42 ± 5 3.0 ± 0.5 3.3 ± 0.5 3.5 ± 0.6 3.0 ± 1.0 3.5 ± 0.7 2.4 ± 0.3 2.1 ± 0.4 2.2 ± 0.5 2.1 ± 0.5 2.7 ± 0.2 trauma
ALN_2017_08_02_GROTTKE_ALN-D-17-00166R2_SDC1.docx