B – IARC 112 The studies that were referenced in the IARC monograph that the OCS Tier 1 assessment concluded required further assessment to determine their relevance to the carcinogenicity classification of glyphosate are presented below in Table 7. The APVMA will rely on international assessments of these studies to determine whether glyphosate should be placed under formal reconsideration. Table 7: List of studies recommended by the OCS for further assessment to determine if relevant to carcinogenicity classification of glyphosate Formulation Author(s) Year Endpoint Species Title/publication details Comments Website type (if stated) *Alavanja, MC, 2003 Carcinogenicity/ unknown human Use of agricultural pesticides No direct reference Samanic, C, epidemiology formulation and prostate cancer risk in the to glyphosate in Dosemeci, M, Lubin, Agricultural Health Study abstract, increased J, Tarone, R, Lynch, cohort. American Journal of risk to ‘other CF, Knott, C, Epidemiology,157(9), 800–14 only pesticides’ Thomas, K, Hoppin, seen in subjects JA, Barker, J, Coble, with a FHx of J, Sandler, DP & prostate cancer Blair, A. *Astiz, M, de Alaniz, 2009b oxidative stress glyphosate rat Antioxidant defense system in Glyphosate MJ, & Marra, CA. rats simultaneously administered alone intoxicated with and in combo with agrochemicals. Environmental other unclear a.i.’s; toxicology and if results are for pharmacology, 28(3), combo; in vivo rat 465–73 model Astiz, M, Hurtado de 2013 oxidative stress glyphosate wistar rat Pesticide-induced decrease in Oxidative stress Catalfo, GE., rat testicular steroidogenesis seen in testicular García, MN, Galletti, is differentially prevented by cells; investigates SM, Errecalde, AL, lipoate and tocopherol. antioxidant de Alaniz, MJ, & Ecotoxicology and treatment after environmental safety, 91, administration; Marra, CA. 129–38 unclear if administered in combo
B – IARC 112 The studies that were referenced in the IARC monograph that the OCS Tier 1 assessment concluded required further assessment to determine their relevance to the carcinogenicity classification of glyphosate are presented below in Table 7. The APVMA will rely on international assessments of these studies to determine whether glyphosate should be placed under formal reconsideration. Table 7: List of studies recommended by the OCS for further assessment to determine if relevant to carcinogenicity classification of glyphosate Author(s) Year Endpoint Formulation type (if stated) Species Title/publication details Comments Website *Alavanja, MC, Samanic, C, Dosemeci, M, Lubin, J, Tarone, R, Lynch, CF, Knott, C, Thomas, K, Hoppin, JA, Barker, J, Coble, J, Sandler, DP & Blair, A. 2003 Carcinogenicity/ epidemiology unknown formulation human Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. American Journal of Epidemiology,157(9), 800–14 No direct reference to glyphosate in abstract, increased risk to ‘other pesticides’ only seen in subjects with a FHx of prostate cancer *Astiz, M, de Alaniz, MJ, & Marra, CA. 2009b oxidative stress glyphosate rat Antioxidant defense system in rats simultaneously intoxicated with agrochemicals. Environmental toxicology and pharmacology, 28(3), 465–73 Glyphosate administered alone and in combo with other a.i.’s; unclear if results are for combo; in vivo rat model Astiz, M, Hurtado de Catalfo, GE., García, MN, Galletti, SM, Errecalde, AL, de Alaniz, MJ, & Marra, CA. 2013 oxidative stress glyphosate wistar rat Pesticide-induced decrease in rat testicular steroidogenesis is differentially prevented by lipoate and tocopherol. Ecotoxicology and environmental safety, 91, 129–38 Oxidative stress seen in testicular cells; investigates antioxidant treatment after administration; unclear if administered in combo
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