SD: Sprague Dawley; MTD: maximum tolerated dose; HD: high dose; MD: median dose; LD: low dose; M: males; F: females; GLP: good laboratory practice; OECD (TG): the organisation for economic co-operation and development (testing guideline) Discussion and OCS conclusion All of the studies evaluated by were assessed and cited by the EFSA RAR (). Based on a review of the supplementary raw data provided within the documents and in parallel with the conclusions of the EFSA RAR (), the OCS conclusions are consistent with and the EFSA RAR () that the evidence indicates that glyphosate is not carcinogenic in animals. As part of the review of , the cited review paper by was considered. All of the studies reviewed by were referenced by the IARC monograph. Five of the studies cited by were reviewed previously by the OCS in 2005 (; ; ; ; ). The OCS weight-of-evidence conclusion in 2005 was that glyphosate is not mutagenic or carcinogenic and it is unlikely that exposure to glyphosate is associated with an increased risk of NHL. Of the remaining studies cited by , four (; ; ; ) were considered during the Tier 1 assessment as not appropriate for review due to a lack of reference to glyphosate in the abstract and the remaining 12 were indicated in the proposed Tier 2, Part 2 review of the monograph. However, as these papers were critically evaluated by the international JMPR assessment of glyphosate, the proposed Tier 2, Part 2 assessment will not be undertaken by the OCS.
SD: Sprague Dawley; MTD: maximum tolerated dose; HD: high dose; MD: median dose; LD: low dose; M: males; F: females; GLP: good laboratory practice; OECD (TG): the organisation for economic co-operation and development (testing guideline) Discussion and OCS conclusion All of the studies evaluated by were assessed and cited by the EFSA RAR (). Based on a review of the supplementary raw data provided within the documents and in parallel with the conclusions of the EFSA RAR (), the OCS conclusions are consistent with and the EFSA RAR () that the evidence indicates that glyphosate is not carcinogenic in animals. As part of the review of , the cited review paper by was considered. All of the studies reviewed by were referenced by the IARC monograph. Five of the studies cited by were reviewed previously by the OCS in 2005 (; ; ; ; ). The OCS weight-of-evidence conclusion in 2005 was that glyphosate is not mutagenic or carcinogenic and it is unlikely that exposure to glyphosate is associated with an increased risk of NHL. Of the remaining studies cited by , four (; ; ; ) were considered during the Tier 1 assessment as not appropriate for review due to a lack of reference to glyphosate in the abstract and the remaining 12 were indicated in the proposed Tier 2, Part 2 review of the monograph. However, as these papers were critically evaluated by the international JMPR assessment of glyphosate, the proposed Tier 2, Part 2 assessment will not be undertaken by the OCS.
20706-glyphosate-review-of-iarc-monograph-112-by-ocs-tier-2.docx