Supplemental Table 5. Stepwise Multivariate Time-Dependent Analysis for OS Coefficient* Variable Hazard Ratio P value Estimate SE TE grade 3 infection 2.205 0.244 9.07 < 2 × ≥ 10−16 Systolic blood pressure 108 mm Hg 0.550 0.165 1.73 8.60 × ≤ 10−4 History of bone, calcium, magnesium, and phosphorus metabolism 0.281 0.158 1.32 = yes 7.64 × disorders† 10−2 Serum 8.38 mg/L 0.352 0.118 1.42 2.80 × β2-microglobulin ≥ 10−3 = yes 0.75 7.65 × Renal insufficiency‡ −0.289 −0.163 10−2 High-risk cytogenetics§ = yes 0.702 0.120 2.02 4.81 × 10−9 ECOG PS 2 0.332 0.101 1.39 9.71 × ≥ 10−4 Fitness category combined with ISS = frail with ISS stage III 0.76 3.33 × stage‖ −0.269 −0.127 10−2 Absolute lymphocytes 0.9 × 109/L 0.402 0.104 1.50 1.02 × ≤ 10−4 ISS stage 3 0.474 0.125 1.61 1.59 × ≥ 10−4 Red blood cells 3.1 × 1012/L 0.287 0.088 1.33 1.16 × ≤ 10−3 Global quality of life 50 0.284 0.092 1.33 ≤ 2.05×10−3 globulin 5% 0.174 0.099 1.19 7.91 × α-1 ≥ 10−2
Supplemental Table 5. Stepwise Multivariate Time-Dependent Analysis for OS Variable Coefficient* Hazard Ratio P value Estimate SE TE grade ≥ 3 infection 2.205 0.244 9.07 < 2 × 10−16 Systolic blood pressure ≤ 108 mm Hg 0.550 0.165 1.73 8.60 × 10−4 History of bone, calcium, magnesium, and phosphorus metabolism disorders† = yes 0.281 0.158 1.32 7.64 × 10−2 Serum β2-microglobulin ≥ 8.38 mg/L 0.352 0.118 1.42 2.80 × 10−3 Renal insufficiency‡ = yes −0.289 −0.163 0.75 7.65 × 10−2 High-risk cytogenetics§ = yes 0.702 0.120 2.02 4.81 × 10−9 ECOG PS ≥ 2 0.332 0.101 1.39 9.71 × 10−4 Fitness category combined with ISS stage‖ = frail with ISS stage III −0.269 −0.127 0.76 3.33 × 10−2 Absolute lymphocytes ≤ 0.9 × 109/L 0.402 0.104 1.50 1.02 × 10−4 ISS stage ≥ 3 0.474 0.125 1.61 1.59 × 10−4 Red blood cells ≤ 3.1 × 1012/L 0.287 0.088 1.33 1.16 × 10−3 Global quality of life ≤ 50 0.284 0.092 1.33 2.05×10−3 α-1 globulin ≥ 5% 0.174 0.099 1.19 7.91 × 10−2
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