M: 115 g & F2 50 ppm: [LOAEL = 150 ppm: decreased body Record No.: generations weight] F: 101 g M 4.3 4.2 MO-02-002596 / F 5.5 6.0 M-036790-01-1) NOAEL offspring toxicity = 50 ppm: 150 ppm: M = 4.3 & F = 5.5 M 12.5 13.5 [LOAEL = 150 ppm: decreased lactation F 15.4 18.6 index] 500 ppm: M 41.0 43.5 F 52.1 61.3 n = 25 animals/sex/dose/generation Rat Wistar M & F Diet (ad Test material: 99% purity methiocarb Feed Conclusions: Eiben, R. & Bach, U. ≥ libitum) and in CrIGIxBrlHan: Altromin® NOAEL reproductive toxicity = 500 ppm: (2002c) milk during Wl 1321 meal + non-weaned Mean daily active-intake/animal of F0 M = 55.1 & F = 83.9 [highest test dose] 23-October-2002 1% peanut period for & F1 (mg/kg bw/d), per treatment: oil (DAB 10) NOAEL parental toxicity: could not be (Study No.: T 6070 298 pups F0 animals: F0 F1 set: Report-No: AT00047 5–6 wk 0 ppm: At all doses for parental males, Document No.: AT00046 2-generation decreased erythrocyte AChE M & F 0 0 / study: F0, F1 & F2 F0 animals: 50 ppm: MO-02-0015935 generations NOAEL offspring toxicity = 150 ppm: M: 126 g M 4.6 5.6 Record No.: M = 14.8 & F = 21.3 F: 109 g F 6.9 7.6 MO-02-0015935 / [LOAEL = 500 ppm: decreased pup 150 ppm: M-064945-01-1) weight, lactation index & litter size] M 14.8 16.3 F 21.3 22.3
M: 115 g F: 101 g & F2 generations 50 ppm: M 4.3 4.2 F 5.5 6.0 150 ppm: M 12.5 13.5 F 15.4 18.6 500 ppm: M 41.0 43.5 F 52.1 61.3 n = 25 animals/sex/dose/generation [LOAEL = 150 ppm: decreased body weight] NOAEL offspring toxicity = 50 ppm: M = 4.3 & F = 5.5 [LOAEL = 150 ppm: decreased lactation index] Record No.: MO-02-002596 / M-036790-01-1) Rat Wistar CrIGIxBrlHan: Wl F0 animals: 5–6 wk F0 animals: M: 126 g F: 109 g M & F Diet (ad libitum) and in milk during non-weaned period for pups 2-generation study: F0, F1 & F2 generations Test material: ≥ 99% purity methiocarb Mean daily active-intake/animal of F0 & F1 (mg/kg bw/d), per treatment: F0 F1 0 ppm: M & F 0 0 50 ppm: M 4.6 5.6 F 6.9 7.6 150 ppm: M 14.8 16.3 F 21.3 22.3 Feed Altromin® 1321 meal + 1% peanut oil (DAB 10) Conclusions: NOAEL reproductive toxicity = 500 ppm: M = 55.1 & F = 83.9 [highest test dose] NOAEL parental toxicity: could not be set: At all doses for parental males, decreased erythrocyte AChE NOAEL offspring toxicity = 150 ppm: M = 14.8 & F = 21.3 [LOAEL = 500 ppm: decreased pup weight, lactation index & litter size] Eiben, R. & Bach, U. (2002c) 23-October-2002 (Study No.: T 6070 298 Report-No: AT00047 Document No.: AT00046 / MO-02-0015935 Record No.: MO-02-0015935 / M-064945-01-1)
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