metastasis through regulation of cell polarity and differentiation programs, and independent of Snail1. Plate no. (2): Mild to moderate cytoplasmic Plate no. (1): Sections examined from normal LOXL2 expression in the covering psoriatic epidermis skin biopsy displays diffuse mild to moderate (Immunoperoxidaseoriginal magnification 100 cytoplasmic LOXL2 expression XHPF). (Immunoperoxidaseoriginal magnification 40XHPF). Table (1): Immunohistochemical expression of LOXL2 in normal skin. LOXL2 expression in normal skin Normal skin N = 10 No % Expression Positive 10 100 Negative 0 0 Intensity Mild moderate 9 90.0 – Mild strong 0 0.0 Moderate strong 1 10.0 – Distribution Patchy 8 80.0 Diffuse 2 20.0 Cellular localization Cytoplasmic 10 100 Other patterns 0 0 Percent X ±SD 25.0±15.63 Range 10 50 – H score X ±SD 35.0±30.91 Range 10 110 – Stroma No % Expression Positive 10 100 Negative 0 0 Type Inflammatory 8 80.0 Adnexa 0 0.0 Adnexa & inflammatory 2 20.0 Table (2): Immunohistochemical expression of LOXL2 in psoriasis Psoriasis N = 20 No % Expression Positive 15 75.0 Negative 5 25.0 Intensity Mild moderate 12 80.0 – Mild strong 0 0.0 Moderate strong 3 20.0 – Distribution Patchy 15 100 Diffuse 0 0 Cellular localization Cytoplasmic 15 100 Other patterns 0 0
metastasis through regulation of cell polarity and differentiation programs, and independent of Snail1. Plate no. (1): Sections examined from normal skin biopsy displays diffuse mild to moderate cytoplasmic LOXL2 expression (Immunoperoxidaseoriginal magnification 40XHPF). Plate no. (2): Mild to moderate cytoplasmic LOXL2 expression in the covering psoriatic epidermis (Immunoperoxidaseoriginal magnification 100 XHPF). Table (1): Immunohistochemical expression of LOXL2 in normal skin. LOXL2 expression in normal skin Normal skin N = 10 No % Expression Positive Negative 10 0 100 0 Intensity Mild – moderate Mild strong Moderate – strong 9 0 1 90.0 0.0 10.0 Distribution Patchy Diffuse 8 2 80.0 20.0 Cellular localization Cytoplasmic Other patterns 10 0 100 0 Percent X ±SD Range 25.0±15.63 10 – 50 H score X ±SD Range 35.0±30.91 10 – 110 Stroma No % Expression Positive Negative 10 0 100 0 Type Inflammatory Adnexa Adnexa & inflammatory 8 0 2 80.0 0.0 20.0 Table (2): Immunohistochemical expression of LOXL2 in psoriasis Psoriasis N = 20 No % Expression Positive Negative 15 5 75.0 25.0 Intensity Mild – moderate Mild strong Moderate – strong 12 0 3 80.0 0.0 20.0 Distribution Patchy Diffuse 15 0 100 0 Cellular localization Cytoplasmic Other patterns 15 0 100 0
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