Table 5 Air quality and air flow patterns Requirements Nonconformity guide 5.1 Air flow patterns must be such as to prevent air Minor from flowing from biosecurity isolation areas to other areas unless HEPA filtered and prevent dead pockets. 5.2 Ventilation must give negative pressure in the lab. Major Inward flow is required if imported animals are sharing a common air supply with non-imported animals (except in the case of specific pathogen free (SPF) animals where they would be in an isolator of SPF barrier). 5.3 Intake air should be 100 per cent fresh Minor to avoid cross-contamination by infectious agents and to dispose of irritating chemicals, primarily ammonia). 5.4 Intake air should not be contaminated by exhaust Minor air from the site, incinerator smoke, or other contaminated air. 5.5 There must be at least eight fresh air changes each Minor hour. 5.6 Vacuum lines and air outlets should, where Major necessary, be protected by high efficiency particulate air filters (HEPA) and liquid disinfectant traps.
Table 5 Air quality and air flow patterns Requirements Nonconformity guide 5.1 Air flow patterns must be such as to prevent air from flowing from biosecurity isolation areas to other areas unless HEPA filtered and prevent dead pockets. Minor 5.2 Ventilation must give negative pressure in the lab. Inward flow is required if imported animals are sharing a common air supply with non-imported animals (except in the case of specific pathogen free (SPF) animals where they would be in an isolator of SPF barrier). Major 5.3 Intake air should be 100 per cent fresh to avoid cross-contamination by infectious agents and to dispose of irritating chemicals, primarily ammonia). Minor 5.4 Intake air should not be contaminated by exhaust air from the site, incinerator smoke, or other contaminated air. Minor 5.5 There must be at least eight fresh air changes each hour. Minor 5.6 Vacuum lines and air outlets should, where necessary, be protected by high efficiency particulate air filters (HEPA) and liquid disinfectant traps. Major
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