The 2005 environmental assessment did not assess potential impacts of metabolite exposure. The DotE 2006 assessment appears to have considered metabolites in terms of their fate characteristics but not for toxicity or quantification of risk. A large body of information was submitted with the new data to consider potential formation fractions of different metabolites in terrestrial and aquatic environments, and considering the toxicity of these metabolites to the range of aquatic organisms. The following table shows structures and names of the major metabolites. Table 1: Structures and names of methiocarb and major metabolites Compound Structure Comments Methiocarb M01 (Methiocarb Major soil (up to sulfoxide) 60%) and water (up to 25%) metabolite. M02 Intermediate. M03 (Methiocarb phenol) Major water (up to 83%) metabolite. M04 (Methiocarb Major soil (up to sulfoxide phenol) 36%) and water (up to 63%) metabolite. M05 (Methiocarb sulfone Major soil (up to phenol) 20%) metabolite. M10 (Methiocarb Major soil (up to methoxy sulphone) 13%) metabolite.
The 2005 environmental assessment did not assess potential impacts of metabolite exposure. The DotE 2006 assessment appears to have considered metabolites in terms of their fate characteristics but not for toxicity or quantification of risk. A large body of information was submitted with the new data to consider potential formation fractions of different metabolites in terrestrial and aquatic environments, and considering the toxicity of these metabolites to the range of aquatic organisms. The following table shows structures and names of the major metabolites. Table 1: Structures and names of methiocarb and major metabolites Compound Structure Comments Methiocarb M01 (Methiocarb sulfoxide) Major soil (up to 60%) and water (up to 25%) metabolite. M02 Intermediate. M03 (Methiocarb phenol) Major water (up to 83%) metabolite. M04 (Methiocarb sulfoxide phenol) Major soil (up to 36%) and water (up to 63%) metabolite. M05 (Methiocarb sulfone phenol) Major soil (up to 20%) metabolite. M10 (Methiocarb methoxy sulphone) Major soil (up to 13%) metabolite.
32336-methiocarb_-_environment_report_-_chem_review_-_publication_version.docx