ADP breakdown and synthesis kbreakdown,ADP rate constant for 0.000224 µM-1.s-1 (*) optimized breakdown of (8.3 10-5) (IQR) ADP ksynthesis,ADP rate constant for 0.001261 s-1 (*) optimized synthesis of ADP (0.00028) (IQR) Storage carbon metabolites from glycolytic intermediates kstore rate constant for 0.005202 s-1 (*) optimized storage of carbon (0.00043) (IQR) metabolites Parameters algebraic equations NADtot total 200 µM (13, 14) nicotinamide adenine dinucleotide content ratioP/O2 ratio of ATP 5.6 dimensionless (15-17) synthesized per O2 consumed RPGI/FBP ratio of total 1.243 (0.047) dimensionless (*) optimized phosphorylated (IQR); glycolytic total intermediates phosphorylated content to glycolytic fructose intermediates varying with content fixed ratio to FBP; other stores of metabolites increase in time (Eq. 9) and are not proportional to FBP. Cf. (13, 16, 18-24) Inhibition of head section of glycolysis kf second order µM-1s-1 (*) optimized 1.01∙10-5 forward rate (7.5 10-7) (IQR) constant for inhibition by glycolytic intermediates kb backward rate 0.00315 s-1 (*) optimized constant for (0.00034) (IQR) disinhibition of head section
ADP breakdown and synthesis kbreakdown,ADP rate constant for breakdown of ADP 0.000224 (8.3 10-5) µM-1.s-1 (*) optimized (IQR) ksynthesis,ADP rate constant for synthesis of ADP 0.001261 (0.00028) s-1 (*) optimized (IQR) Storage carbon metabolites from glycolytic intermediates kstore rate constant for storage of carbon metabolites 0.005202 (0.00043) s-1 (*) optimized (IQR) Parameters algebraic equations NADtot total nicotinamide adenine dinucleotide content 200 µM (13, 14) ratioP/O2 ratio of ATP synthesized per O2 consumed 5.6 dimensionless (15-17) RPGI/FBP ratio of total phosphorylated glycolytic intermediates content to fructose content 1.243 (0.047) dimensionless (*) optimized (IQR); total phosphorylated glycolytic intermediates varying with fixed ratio to FBP; other stores of metabolites increase in time (Eq. 9) and are not proportional to FBP. Cf. (13, 16, 18-24) Inhibition of head section of glycolysis kf second order forward rate constant for inhibition by glycolytic intermediates 1.01∙10-5 (7.5 10-7) µM-1s-1 (*) optimized (IQR) kb backward rate constant for disinhibition of head section 0.00315 (0.00034) s-1 (*) optimized (IQR)
3809938c-1766-4e94-b3b6-11adfe5738df.docx