B5.1e 3/4 Starter describe how genetic variants may influence phenotype: Use the lighting in the class as an example. The light is analogous to a gene. The switch is in coding DNA by altering the analogous to the genes regulatory region. What activity of a protein to include: DNA would happen if the light bulb was broken? What related to mutations affecting would happen if the switch was broken? protein structure, including active sites of enzymes Main in non-coding DNA by altering how genes are expressed to include: Introduce what happens to a gene when it is DNA related to stopping DNA mRNA to protein. If the transcription of mRNA (use of terms ‘switched on’. – gene is not switched on then the mRNA is not promoter, transcription factor not produced. Therefore the protein is not produced. required) Use the British Library analogy In coding DNA introduce students to the genetic code. Although this is not included in the specification it may be easier to teach from this aspect. Introduce the triplet and for more able learners introduce the a triplet of reason why it’s bases.
3/4 B5.1e describe how genetic variants may influence phenotype: in coding DNA by altering the activity of a protein to include: DNA related to mutations affecting protein structure, including active sites of enzymes in non-coding DNA by altering how genes are expressed to include: DNA related to stopping transcription of mRNA (use of terms promoter, transcription factor not required) Starter Use the lighting in the class as an example. The light is analogous to a gene. The switch is analogous to the genes regulatory region. What would happen if the light bulb was broken? What would happen if the switch was broken? Main Introduce what happens to a gene when it is ‘switched on’. DNA – mRNA to protein. If the gene is not switched on then the mRNA is not produced. Therefore the protein is not produced. Use the British Library analogy In coding DNA introduce students to the genetic code. Although this is not included in the specification it may be easier to teach from this aspect. Introduce the triplet and for more able learners introduce the reason why it’s a triplet of bases.
413714-topic-b5-suggested-teaching-hours-and-outline-scheme-of-work.docx