Supplemental Table 7. Baseline Patient Characteristics Associated With Increased or Decreased Risk of TE Grade 3 ≥ Infection in the First 4 Months Found with an Exploratory Univariate Analysis using the Q-Finder algorithm Patients With TE Patients, Variable Grade 3 Odds Ratio (CI) P Value ≥ n (%) Infections, % All patients (analysis set) 1 378 (100) 13.9 Fitness category combined with ISS stage* = frail with ISS stage III 308 (22.4) 22.7 2.31 (1.7-3.2) 8.25 × 10−7 ECOG PS 280 (20.3) 22.5 2.20 (1.6-3.1) 5.97 × ≥ 2† 10−6 478 (34.7) 24.1 3.43 (2.5-4.7) 6.66 × Serum 10−15 β2-microglobulin ≥ 5.94 mg/L† Serum 2.89 207 (15.0) 3.4 0.19 (0.1-0.4) 7.79 × β2-microglobulin ≤ mg/L† 10−8 M-protein urine 616.1 mg/24 h 376 (27.3) 20.7 2.06 (1.5-2.8) 8.33 × ≥ 10−6 Urea 23 mg/dL 452 (32.8) 21.0 2.30 (1.7-3.1) 1.24 × ≥ 10−7 Urea 19 mg/dL 731 (53.0) 9.8 0.48 (0.4-0.7) 3.26 × ≤ 10−6 globulin (corrected) 0.4 g/dL 624 (45.3) 18.9 2.18 (1.6-3.0) 6.10 × α-1 ≥ 10−7 Creatinine 445 (32.3) 20.4 2.14 (1.6-2.9) 1.36 × ≥ 1.2 mg/dL† 10−6 Lactate dehydrogenase 200 242 (17.6) 24.0 2.38 (1.7-3.4) 1.79 × ≥ U/L† 10−6
Supplemental Table 7. Baseline Patient Characteristics Associated With Increased or Decreased Risk of TE Grade ≥ 3 Infection in the First 4 Months Found with an Exploratory Univariate Analysis using the Q-Finder algorithm Variable Patients, n (%) Patients With TE Grade ≥ 3 Infections, % Odds Ratio (CI) P Value All patients (analysis set) 1 378 (100) 13.9 Fitness category combined with ISS stage* = frail with ISS stage III 308 (22.4) 22.7 2.31 (1.7-3.2) 8.25 × 10−7 ECOG PS ≥ 2† 280 (20.3) 22.5 2.20 (1.6-3.1) 5.97 × 10−6 Serum β2-microglobulin ≥ 5.94 mg/L† 478 (34.7) 24.1 3.43 (2.5-4.7) 6.66 × 10−15 Serum β2-microglobulin ≤ 2.89 mg/L† 207 (15.0) 3.4 0.19 (0.1-0.4) 7.79 × 10−8 M-protein urine ≥ 616.1 mg/24 h 376 (27.3) 20.7 2.06 (1.5-2.8) 8.33 × 10−6 Urea ≥ 23 mg/dL 452 (32.8) 21.0 2.30 (1.7-3.1) 1.24 × 10−7 Urea ≤ 19 mg/dL 731 (53.0) 9.8 0.48 (0.4-0.7) 3.26 × 10−6 α-1 globulin (corrected) ≥ 0.4 g/dL 624 (45.3) 18.9 2.18 (1.6-3.0) 6.10 × 10−7 Creatinine ≥ 1.2 mg/dL† 445 (32.3) 20.4 2.14 (1.6-2.9) 1.36 × 10−6 Lactate dehydrogenase ≥ 200 U/L† 242 (17.6) 24.0 2.38 (1.7-3.4) 1.79 × 10−6
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