COHORT STUDIES (Ong 2011) Selection 1) Representativeness of the exposed cohort chronic hepatitis B patients withHBsAg a) truly representative of the average _ (describe) in the  community  b) somewhat representative of the average ______________ in the community c) selected group of users eg nurses, volunteers d) no description of the derivation of the cohort 2) Selection of the non exposed cohort √ a) drawn from the same community as the exposed cohort b) drawn from a different source c) no description of the derivation of the non exposed cohort 3) Ascertainment of exposure √ a) secure record (eg surgical records)  b) structured interview c) written self report d) no description 4) Demonstration that outcome of interest was not present at start of study √ a) yes b) no Comparability 1) Comparability of cohorts on the basis of the design or analysis  a) study controls for _____________ (select the most important factor)  b) study controls for any additional factor (This criteria could be modified to indicate specific control for a second important factor.) Outcome 1) Assessment of outcome  a) independent blind assessment √  b) record linkage c) self report d) no description 2) Was follow-up long enough for outcomes to occur √ a) yes (select an adequate follow up period for outcome of interest) b) no 3) Adequacy of follow up of cohorts  a) complete follow up - all subjects accounted for √ b) subjects lost to follow up unlikely to introduce bias - small number lost - > ____ % (select an  adequate %) follow up, or description provided of those lost) c) follow up rate < ____% (select an adequate %) and no description of those lost d) no statement
COHORT STUDIES (Ong 2011) Selection 1) Representativeness of the exposed cohort a) truly representative of the average _ chronic hepatitis B patients withHBsAg (describe) in the community  b) somewhat representative of the average ______________ in the community  c) selected group of users eg nurses, volunteers d) no description of the derivation of the cohort 2) Selection of the non exposed cohort a) drawn from the same community as the exposed cohort √ b) drawn from a different source c) no description of the derivation of the non exposed cohort 3) Ascertainment of exposure a) secure record (eg surgical records) √ b) structured interview  c) written self report d) no description 4) Demonstration that outcome of interest was not present at start of study a) yes √ b) no Comparability 1) Comparability of cohorts on the basis of the design or analysis a) study controls for _____________ (select the most important factor)  b) study controls for any additional factor  (This criteria could be modified to indicate specific control for a second important factor.) Outcome 1) Assessment of outcome a) independent blind assessment  √ b) record linkage  c) self report d) no description 2) Was follow-up long enough for outcomes to occur a) yes (select an adequate follow up period for outcome of interest) √ b) no 3) Adequacy of follow up of cohorts a) complete follow up - all subjects accounted for  √ b) subjects lost to follow up unlikely to introduce bias - small number lost - > ____ % (select an adequate %) follow up, or description provided of those lost)  c) follow up rate < ____% (select an adequate %) and no description of those lost d) no statement
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