28- 30 days You will have a physical exam, which will include measuring your height, blood pressure, heart rate, weight Day 56 Approx. 2 and a check for evidence of “neuropathy” aka nerve damage and tests of balance after D28 hours (2 months) Blood (about 3.8 teaspoons) will be taken for routine tests**, and to check the level of DCA in the blood and to check the level of paraprotein or light chains in your blood (DCA taken after drug, adherence level assessment) You will have a physical exam, which will include measuring your height, blood pressure, heart rate, weight Day 84 28-30 days Approx. 2 and a check for evidence of “neuropathy” or nerve damage after D56 hours (3 months) You will be asked how well you are able to perform the normal activities of daily living (a performance status evaluation) You will have your blood pressure and electrocardiograms (“ECGs”, tests that measure the electrical activity of the heart) taken Blood (about 3.8 teaspoons) will be taken for routine tests**, and to check the level of DCA in the blood and to check the level of paraprotein or light chains in your blood Today is the last day that you will take the DCA You will have a physical exam and check for evidence of neuropathy (nerve damage). Day 168 84-91 days Approx 2hrs You will have blood taken (around 1.7 tspn) to check the paraprotein level. after D 84 (6 months) You will have a physical exam and check for evidence of neuropathy (nerve damage) Day 252 84-91 days Approx 2hrs You will have blood taken (around 1.7 tpsn) to check the paraprotein level. after D 168 (9 months) **(FBP, UEC, LFT, LDH, , glucose, CK, CMP, Lipase)
Day 56 (2 months) 28- 30 days after D28 Approx. 2 hours You will have a physical exam, which will include measuring your height, blood pressure, heart rate, weight and a check for evidence of “neuropathy” aka nerve damage and tests of balance Blood (about 3.8 teaspoons) will be taken for routine tests**, and to check the level of DCA in the blood and to check the level of paraprotein or light chains in your blood (DCA taken after drug, adherence level assessment) Day 84 (3 months) 28-30 days after D56 Approx. 2 hours You will have a physical exam, which will include measuring your height, blood pressure, heart rate, weight and a check for evidence of “neuropathy” or nerve damage You will be asked how well you are able to perform the normal activities of daily living (a performance status evaluation) You will have your blood pressure and electrocardiograms (“ECGs”, tests that measure the electrical activity of the heart) taken Blood (about 3.8 teaspoons) will be taken for routine tests**, and to check the level of DCA in the blood and to check the level of paraprotein or light chains in your blood Today is the last day that you will take the DCA Day 168 (6 months) 84-91 days after D 84 Approx 2hrs You will have a physical exam and check for evidence of neuropathy (nerve damage). You will have blood taken (around 1.7 tspn) to check the paraprotein level. Day 252 (9 months) 84-91 days after D 168 Approx 2hrs You will have a physical exam and check for evidence of neuropathy (nerve damage) You will have blood taken (around 1.7 tpsn) to check the paraprotein level. **(FBP, UEC, LFT, LDH, , glucose, CK, CMP, Lipase)
367868-DiCAM%20Protocol%20-%20Version%201%200.docx