Observation period: 72 h Conclusion: Methiocarb is not a skin irritant. Eye irritation Species Strain, age Sex Route Test parameters (e.g. Vehicle Toxicology conclusion/s Reference dose) information weight Rabbit NZ White M & F Ocular 0.1 g dose of test item Nil Results: Collor, L.V.M. (undiluted) Young adult The test item applied in the eye of the rabbits caused slight (2005b) changes on the conjunctivae: hyperaemia grade 1, at the (conjunctival 27-Sept-2005 time point in 3/3 test eyes. Test material: methiocarb 14–16 wk sac of the (Report-No: RF - (purity: 98.2%) All irritation signs had returned to normal by the 24-h time left eye). point following treatment. 0030.312.405.05 Additional ocular effect noted was miosis (contraction of the 3.107–3.398 kg Document No.: n = 3 (2F, 1M) pupil) at the 1-h time point in 1/3 animals. M-261818-01-1) There were no other behavioural and clinical alterations observed. Exposure Time: ~1 h (then eye-rinse) Conclusion: Observation period: 72 h Methiocarb is not an eye irritant.
Observation period: 72 h Conclusion: Methiocarb is not a skin irritant. Eye irritation Species Strain, age weight Sex Route Test parameters (e.g. dose) Vehicle Toxicology conclusion/s Reference information Rabbit NZ White Young adult 14–16 wk 3.107–3.398 kg M & F Ocular (conjunctival sac of the left eye). 0.1 g dose of test item (undiluted) Test material: methiocarb (purity: 98.2%) n = 3 (2F, 1M) Exposure Time: ~1 h (then eye-rinse) Observation period: 72 h Nil Results: The test item applied in the eye of the rabbits caused slight changes on the conjunctivae: hyperaemia grade 1, at the time point in 3/3 test eyes. All irritation signs had returned to normal by the 24-h time point following treatment. Additional ocular effect noted was miosis (contraction of the pupil) at the 1-h time point in 1/3 animals. There were no other behavioural and clinical alterations observed. Conclusion: Methiocarb is not an eye irritant. Collor, L.V.M. (2005b) 27-Sept-2005 (Report-No: RF - 0030.312.405.05 Document No.: M-261818-01-1)
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