inhibits COX enzyme results in the decrease in the production of prostaglandins and thromboxanes, the key molecules that affect various physiological responses including transmission of pain, regulation of inflammation and fever, as well as aggregation of platelets. In this task, you will: Perform the synthesis of acetylsalicylic acid the esterification of salicylic acid with acetic via anhydride. Calculate % yield of the purified product. Perform thin layer chromatography analysis. Chemicals Acetic anhydride Ethyl acetate Concentrated H2SO4 (18 mol dm-3) Hexane Distilled Water Ice (for an ice bath) Ethanol Salicylic acid Glasswares Beaker, 100 cm3 Buchner funnel Crystallizing dish (for a hot water bath and an ice bath) Erlenmeyer flasks, 125 cm3 and 250 cm3 Filter paper Graduated cylinder, 25 cm3 Pasteur pipet and rubber bulb Stirring rod Spatula Suction flask Capillary tube for TLC TLC plate on aluminum foil or glass supports and TLC jar Instruments Analytical balance ( 0.0001 g) Hotplate Water aspirator or vacuum pump Stand and clamps Procedure: 1. Weigh out 5.00 g of salicylic acid. Transfer this to a 125 cm3 Erlenmeyer flask. Record the mass.
inhibits COX enzyme results in the decrease in the production of prostaglandins and thromboxanes, the key molecules that affect various physiological responses including transmission of pain, regulation of inflammation and fever, as well as aggregation of platelets. In this task, you will: Perform the synthesis of acetylsalicylic acid via the esterification of salicylic acid with acetic anhydride. Calculate % yield of the purified product. Perform thin layer chromatography analysis. Chemicals Acetic anhydride Ethyl acetate Concentrated H2SO4 (18 mol dm-3) Hexane Distilled Water Ice (for an ice bath) Ethanol Salicylic acid Glasswares Beaker, 100 cm3 Buchner funnel Crystallizing dish (for a hot water bath and an ice bath) Erlenmeyer flasks, 125 cm3 and 250 cm3 Filter paper Graduated cylinder, 25 cm3 Pasteur pipet and rubber bulb Stirring rod Spatula Suction flask Capillary tube for TLC TLC plate on aluminum foil or glass supports and TLC jar Instruments Analytical balance ( 0.0001 g) Hotplate Water aspirator or vacuum pump Stand and clamps Procedure: 1. Weigh out 5.00 g of salicylic acid. Transfer this to a 125 cm3 Erlenmeyer flask. Record the mass.
49th_IChO_PreparatoryProblem.docx