* : U = Unknown n = 10/sex/dose/generation Developmental Toxicity Rat Wistar F only Oral gavage Test material: 99% purity 0.5% Conclusions: Young, A.D. ≥ methiocarb (Hannover) Carboxy- Maternal NOAEL: 0.49 mg/kg bw/d 18-Jan-2002 Methyl- LOAEL = 1.49 based on muscle (Study No.: 01-T12-DV BR Doses: 0, 0.5, 1.5 or 5 5 mg/kg bw/d fasciculations cellulose Report-No: 10923 Age: and 0.4% Document No.: Tween 80 in F: 15 w 2 d n = 30 Developmental NOAEL: >5 mg/kg bw/d deionized 01-T12-DV / water Mean body [LOAEL: >5] M-038693-01-1) weight females: 211.6–214.0 g Dermal absorption Species Strain, age, Sex Route Test parameters (e.g. Vehicle Toxicology conclusion/s Reference weight dose) information Rat & Sprague M & F Dermal Methiocarb µg /cm2 FS*(High dose) Results: Maas, W.J.M. human Dawley absorption 4738.4 FS (mid dose) Relative 24 h skin absorption (%) via epidermis: 9-Nov-2001 25 d (in vitro) 2283.4 (repeat) FS (low dose) (TNO Report No.: 5.51 V 3859
* : U = Unknown n = 10/sex/dose/generation Developmental Toxicity Rat Wistar (Hannover) BR Age: F: 15 w 2 d Mean body weight females: 211.6–214.0 g F only Oral gavage Test material: ≥ 99% purity methiocarb Doses: 0, 0.5, 1.5 or 5 5 mg/kg bw/d n = 30 0.5% Carboxy- Methyl- cellulose and 0.4% Tween 80 in deionized water Conclusions: Maternal NOAEL: 0.49 mg/kg bw/d LOAEL = 1.49 based on muscle fasciculations Developmental NOAEL: >5 mg/kg bw/d [LOAEL: >5] Young, A.D. 18-Jan-2002 (Study No.: 01-T12-DV Report-No: 10923 Document No.: 01-T12-DV / M-038693-01-1) Dermal absorption Species Strain, age, weight Sex Route Test parameters (e.g. dose) Vehicle Toxicology conclusion/s Reference information Rat & human Sprague Dawley 25 d M & F Dermal absorption (in vitro) Methiocarb µg /cm2 4738.4 2283.4 (repeat) 5.51 FS*(High dose) FS (mid dose) FS (low dose) Results: Relative 24 h skin absorption (%) via epidermis: Maas, W.J.M. 9-Nov-2001 (TNO Report No.: V 3859
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