Table 1 – Summary of Case Reports describing acute Phenibut toxicity Case Age, Sex Symptoms Comorbidity Phenibut Concomitant Analytical Ref number Exposure Medications/Drugs Confirmation Sedation, myoclonic Opioid abuse NR NR No () 1 33F jerking 2 23M Lethargic Substance abuse NR NR No () 3 Lethargic, tonic-clonic Anxiety, chronic NR Opioid, unspecified No () 59F seizure pain 4 Agitation interspersed Depression, anxiety, 30g in 24 hours Nil Powder confirmed () 43M with somnolence insomnia as phenibut 5 Sedated but delirious Nil 25g over 24 Nil No () 20F when roused hours 6 Agitated delirium Delirium NR Alcohol and cannabis Phenibut detected () 38M in blood 7 25M Minimally responsive Alcohol 3g/day for 4 Venlafaxine, mirtazapine No () dependence, days depression Table 1 Legend NR – Not reported Table 2 – Summary of Case Reports describing Phenibut withdrawal Case Age, Sex Symptoms Comorbidity Phenibut Concomitant Analytical Ref number Exposure Medications/Drugs Confirmation 1 Anxiety, anger, Depression 8g/day for 10 Mitragyna speciosa No () 35M
Table 1 – Summary of Case Reports describing acute Phenibut toxicity Case number Age, Sex Symptoms Comorbidity Phenibut Exposure Concomitant Medications/Drugs Analytical Confirmation Ref 1 33F Sedation, myoclonic jerking Opioid abuse NR NR No () 2 23M Lethargic Substance abuse NR NR No () 3 59F Lethargic, tonic-clonic seizure Anxiety, chronic pain NR Opioid, unspecified No () 4 43M Agitation interspersed with somnolence Depression, anxiety, insomnia 30g in 24 hours Nil Powder confirmed as phenibut () 5 20F Sedated but delirious when roused Nil 25g over 24 hours Nil No () 6 38M Agitated delirium Delirium NR Alcohol and cannabis Phenibut detected in blood () 7 25M Minimally responsive Alcohol dependence, depression 3g/day for 4 days Venlafaxine, mirtazapine No () Table 1 Legend NR – Not reported Table 2 – Summary of Case Reports describing Phenibut withdrawal Case number Age, Sex Symptoms Comorbidity Phenibut Exposure Concomitant Medications/Drugs Analytical Confirmation Ref 1 35M Anxiety, anger, Depression 8g/day for 10 Mitragyna speciosa No ()
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