Table VI : Recommendations for antibiotic prophylaxis Nature of operation Likely pathogens Recommended Adult dose antibiotics before surgery Cardiac; prosthetic Staphylococci, Cefazolin 1- IV valve and other conynbacteria, Vancomycin IV procedures enteric Gram-ve cefuroxime IV bacilli Vascular: peripheral Staphylococci, Cefazolin 1- IV bypass or aortic streptococci, enteric Vancomycin 1- IV surgery with Gram-ve bacilli, Cefoxitin 1- IV prosthetic graft clostridia Orthopedic: total Staphylococci Cefazolin 1- IV joint replacement or Vancomycin 1- IV internal fixation of fractures Head and neck, Oral anaerobes, Cefazolin 1- IV entering oral cavity enteric Gram-ve Amipcillin-sulbactam 1.5- IV or pharynx bacilli, staphylococci Clindamycin 600-900 mg/ Gentamycin IV 1.5mg/kg IV Enteric Gram-ve Cefazolin 1- IV patient) bacilli, Gram+ve cocci Biliary Enteric Gram-ve Cefazolin 1- IV bacilli, enterococci, Cefoxitin 1- IV clostridia Cefotatan 1- IV Colorectal Enteric Gram-ve Oral: of each at 1 bacilli,, anaerobes, neomycin+erythromycin PM, 2PM, enterococci base AND 11 PM the day before an 8AM operation Appendectomy (no Enteric Gram-ve Cefoxitin 1- IV perforation bacilli,, anaerobes, Cefotatan 1- IV enterococci Vaginal or abdominal Enteric Gram-ve Cefazolin 1- IV
Table VI : Recommendations for antibiotic prophylaxis Adult dose before surgery Recommended antibiotics Likely pathogens Nature of operation 1- IV IV IV Cefazolin Vancomycin cefuroxime Staphylococci, conynbacteria, enteric Gram-ve bacilli Cardiac; prosthetic valve and other procedures 1- IV 1- IV 1- IV Cefazolin Vancomycin Cefoxitin Staphylococci, streptococci, enteric Gram-ve bacilli, clostridia Vascular: peripheral bypass or aortic surgery with prosthetic graft 1- IV 1- IV Cefazolin Vancomycin Staphylococci Orthopedic: total joint replacement or internal fixation of fractures 1- IV 1.5- IV 600-900 mg/ IV 1.5mg/kg IV Cefazolin Amipcillin-sulbactam Clindamycin Gentamycin Oral anaerobes, enteric Gram-ve bacilli, staphylococci Head and neck, entering oral cavity or pharynx 1- IV Cefazolin Enteric Gram-ve bacilli, Gram+ve cocci patient) 1- IV 1- IV 1- IV Cefazolin Cefoxitin Cefotatan Enteric Gram-ve bacilli, enterococci, clostridia Biliary of each at 1 PM, 2PM, AND 11 PM the day before an 8AM operation Oral: neomycin+erythromycin base Enteric Gram-ve bacilli,, anaerobes, enterococci Colorectal 1- IV 1- IV Cefoxitin Cefotatan Enteric Gram-ve bacilli,, anaerobes, enterococci Appendectomy (no perforation 1- IV Cefazolin Enteric Gram-ve Vaginal or abdominal
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