Transport equations of tissue model Geometric parameters Lcyl length of cm / liter calculated from cylindrical shell tissue radius, per unit volume intracellular water of intracellular content and H2O interstitial space rinner inner radius of cm cylindrical shell router outer radius of cm cylindrical shell Vperivascular volume of blood 0.04 liter / liter (25) vessel and immediately adjacent tissue per volume of intracellular H2O rperivascular radius of the 9.5 µm (26); compatible perivascular with space Vperivascular volume fraction volume 0.50 liter / liter tumor tissue cells consisting of (27, 28) cells as fraction of total tissue volume Cell types fcell type 1 fraction of total cell volume that consists of cells with full tumor glycolytic capacity fcell type 2 fraction of total cell volume that consists of cells with reduced glycolytic capacity Diffusion coefficients DO2 diffusion cm2 s-1 (26, 29, 30) 1.75∙10-5 coefficient of oxygen Dglc diffusion cm2 s-1 (26, 30, 31) 0.5∙10-5 coefficient of glucose Dlac diffusion cm2 s-1 (26, 32) 0.9∙10-5 coefficient of
Transport equations of tissue model Geometric parameters Lcyl length of cylindrical shell per unit volume of intracellular H2O cm / liter calculated from tissue radius, intracellular water content and interstitial space rinner inner radius of cylindrical shell cm router outer radius of cylindrical shell cm Vperivascular volume of blood vessel and immediately adjacent tissue per volume of intracellular H2O 0.04 liter / liter (25) rperivascular radius of the perivascular space 9.5 µm (26); compatible with Vperivascular volume fraction cells volume consisting of cells as fraction of total tissue volume 0.50 liter / liter tumor tissue (27, 28) Cell types fcell type 1 fraction of total cell volume that consists of cells with full tumor glycolytic capacity fcell type 2 fraction of total cell volume that consists of cells with reduced glycolytic capacity Diffusion coefficients DO2 diffusion coefficient of oxygen 1.75∙10-5 cm2 s-1 (26, 29, 30) Dglc diffusion coefficient of glucose 0.5∙10-5 cm2 s-1 (26, 30, 31) Dlac diffusion coefficient of 0.9∙10-5 cm2 s-1 (26, 32)
3809938c-1766-4e94-b3b6-11adfe5738df.docx