[Abdomen] epidermal n = 5 (rat) Radio-Labelled active Comments: MO-05-008896 membranes used: 99% Record No.: ≥ n = 5 (human) Approximately 92% of dose was not absorbed, for both (dermatomed rat and human. M-251996-01-1) [3 donors] skin)] Percent recovery* was ~92% for human and ~93% for Exposure time: 8 h rat. [Swab-washes of skin at 8 h & 24 h] * recovery = surface + skin + receptor compartments Exposure area = 1 cm2 Measure of methiocarb: in skin, at 24 h; on skin, at 8 & 24 h Rat Wistar M Dermal Methiocarb Corn dust Results: Muriel Odin absorption contaminated with Feurtet HsD Single dose to Skin absorption % at 8–168 h after [14C]-methiocarb Cpb:WU (in vivo) exposure areas: 11-March-2005 application of 420 µg/cm2: (Study ID: (Albino) 2 x 30 mg/dust (0.084 mg/mg- dust SA 04293 = 5.04 mg 8 h 24 h 72 h 168 h [nominal]) Document No.: 9–10 wk Dose; 420 µg per cm2: Direct* 0.631% 2.577% 5.268% 7.819% (young SA 04293/ n = 4 adult) Radio-labelled active MO-05-005737) Exposure area = ~ 2 x used: > 99% Total 6.711% 5.130% 8.016% 9.150% 6 cm2 Potential** Exposure time: 8 h * = systemic compartment (e.g. excreta, blood)
[Abdomen] epidermal membranes (dermatomed skin)] n = 5 (rat) n = 5 (human) [3 donors] Exposure time: 8 h [Swab-washes of skin at 8 h & 24 h] Exposure area = 1 cm2 Measure of methiocarb: in skin, at 24 h; on skin, at 8 & 24 h Radio-Labelled active used: ≥ 99% Comments: Approximately 92% of dose was not absorbed, for both rat and human. Percent recovery* was ~92% for human and ~93% for rat. * recovery = surface + skin + receptor compartments MO-05-008896 Record No.: M-251996-01-1) Rat Wistar HsD Cpb:WU (Albino) 9–10 wk (young adult) M Dermal absorption (in vivo) Methiocarb Single dose to exposure areas: 2 x 30 mg/dust = 5.04 mg Dose; 420 µg per cm2: n = 4 Exposure area = ~ 2 x 6 cm2 Exposure time: 8 h Corn dust contaminated with [14C]-methiocarb (0.084 mg/mg- dust [nominal]) Radio-labelled active used: > 99% Results: Skin absorption % at 8–168 h after application of 420 µg/cm2: 8 h 24 h 72 h 168 h Direct* 0.631% 2.577% 5.268% 7.819% Total 6.711% 5.130% 8.016% 9.150% Potential** * = systemic compartment (e.g. excreta, blood) Muriel Odin Feurtet 11-March-2005 (Study ID: SA 04293 Document No.: SA 04293/ MO-05-005737)
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