Sub-chronic toxicity Species Strain, age, weight Sex Route Test parameters (e.g. dose) Vehicle Toxicology conclusion/s Reference information Dog Beagle M & F Diet Test material: > 99% purity methiocarb - Conclusions: Jones, R.D. & Stuart, B.P. NOAEL for plasma cholinesterase = 10 ppm (0.30 and 0.25 mg/kg bw/d in males and 7-Dec-2000 Age: Not >6 m 0, 10, 50 or 250 ppm (equal to 0, 0.3, females respectively). 1.3 or 5.9 mg/kg bw/d in males and 0, (Study No.: 0.25, 1.3 or 6.5 mg/kg bw/d in females) 99-S76-BG Mean bw (g) : Report-No: 109807 M : 9153.5–9437.5 n = 4/sex/treatment Document No.: F: 7081.8–8177.0 Exposure time: 90 day BC9387 / Observation period: 90 days MO-00-016374 Record No.: M-064316-01-1) Rat SPF-bred Wistar M & F Diet Test material: 98.9% purity methiocarb - Conclusions: Kroetlinger, F strain Hsd Cpb:WU Based on reduced relative body weight. 11-Dec-2001 NOAEL = 22.7 and 30.7 mg/kg bw/d in 0, 100, 300 or 900 ppm (equal to 0, (Study No.: males and females respectively. 7.3, 22.7 or 67.6 mg/kg bw/d in males 5-6 wk T 9069 842 and 0, 10.0, 30.7 or 90.7 mg/kg bw/d in females respectively) Report-No: PH 31598 Note: a separate, concurrent Mean initial body Document No.: used 0 ppm & 900 ppm treatments weights: 31598 / only. M 136–139 g MO-01-021994 F 132–137 g Record No.: n = 10/sex/group MO-01-021994 / M-088469-01-1)
Sub-chronic toxicity Species Strain, age, weight Sex Route Test parameters (e.g. dose) Vehicle Toxicology conclusion/s Reference information Dog Beagle Age: Not >6 m Mean bw (g) : M : 9153.5–9437.5 F: 7081.8–8177.0 M & F Diet Test material: > 99% purity methiocarb 0, 10, 50 or 250 ppm (equal to 0, 0.3, 1.3 or 5.9 mg/kg bw/d in males and 0, 0.25, 1.3 or 6.5 mg/kg bw/d in females) n = 4/sex/treatment Exposure time: 90 day Observation period: 90 days - Conclusions: NOAEL for plasma cholinesterase = 10 ppm (0.30 and 0.25 mg/kg bw/d in males and females respectively). Jones, R.D. & Stuart, B.P. 7-Dec-2000 (Study No.: 99-S76-BG Report-No: 109807 Document No.: BC9387 / MO-00-016374 Record No.: M-064316-01-1) Rat SPF-bred Wistar strain Hsd Cpb:WU 5-6 wk Mean initial body weights: M 136–139 g F 132–137 g M & F Diet Test material: 98.9% purity methiocarb 0, 100, 300 or 900 ppm (equal to 0, 7.3, 22.7 or 67.6 mg/kg bw/d in males and 0, 10.0, 30.7 or 90.7 mg/kg bw/d in females respectively) Note: a separate, concurrent used 0 ppm & 900 ppm treatments only. n = 10/sex/group - Conclusions: Based on reduced relative body weight. NOAEL = 22.7 and 30.7 mg/kg bw/d in males and females respectively. Kroetlinger, F 11-Dec-2001 (Study No.: T 9069 842 Report-No: PH 31598 Document No.: 31598 / MO-01-021994 Record No.: MO-01-021994 / M-088469-01-1)
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