1 Question: FEEDBACK: The hallmark lesion of proliferative diabetic retinopathy is Reason answer is correct or incorrect. neovascularization of the retina and/or optic disc a By definition, this is PDR macular edema b This can be seen in any retinopathy vitreous hemorrhage c This can be seen in PDR but is not specific to PDR hard exudates d This is due to breakdown of blood retina barrier and not proliferation of new vessels venous beading e This is due to increased flow, not prolifweration 2 Question: FEEDBACK: retinal neovascularization is the result of Reason answer is correct or incorrect. chronic intraretinal hemorrhages a no decreased protein kinase C activity b Increased PKC may play a role in neovascularization capillary endothelial cell dysfunction c This results in leakage, not proliferation upregulation of VEGF d yes nonperfusion of the optic disc e Nonperfusion in retina upregulates VEGF, not the disc 3 Question: FEEDBACK: complications of neovascular proliferation include (pick all that apply) Reason answer is correct or incorrect. macular edema a This results from breakdown of blood retina barrier hard exudates b This results from breakdown of blood retina barrier vitreous hemorrhage c This can result from ruptured neovascular tissues in PDR traction retinal detachment d This results from contracture of fibrovascular proliferation in PDR cotton wool spots e This is a result of occlusion of precapillary arterioles IRMA f These are dilated capillaries seen in increased flow situations 4 Question: FEEDBACK: Neovascularization of the retina or optic disc may be present in asymptomatic eyes. Reason answer is correct or incorrect. a True Neovascularization by itself produces no change in vision, but complications of neovascular proliferation do cause vision loss by bleeding in the eye or retinal detachment
1 Question: The hallmark lesion of proliferative diabetic retinopathy is FEEDBACK: Reason answer is correct or incorrect. a neovascularization of the retina and/or optic disc By definition, this is PDR b macular edema This can be seen in any retinopathy c vitreous hemorrhage This can be seen in PDR but is not specific to PDR d hard exudates This is due to breakdown of blood retina barrier and not proliferation of new vessels e venous beading This is due to increased flow, not prolifweration 2 Question: retinal neovascularization is the result of FEEDBACK: Reason answer is correct or incorrect. a chronic intraretinal hemorrhages no b decreased protein kinase C activity Increased PKC may play a role in neovascularization c capillary endothelial cell dysfunction This results in leakage, not proliferation d upregulation of VEGF yes e nonperfusion of the optic disc Nonperfusion in retina upregulates VEGF, not the disc 3 Question: complications of neovascular proliferation include (pick all that apply) FEEDBACK: Reason answer is correct or incorrect. a macular edema This results from breakdown of blood retina barrier b hard exudates This results from breakdown of blood retina barrier c vitreous hemorrhage This can result from ruptured neovascular tissues in PDR d traction retinal detachment This results from contracture of fibrovascular proliferation in PDR e cotton wool spots This is a result of occlusion of precapillary arterioles f IRMA These are dilated capillaries seen in increased flow situations 4 Question: Neovascularization of the retina or optic disc may be present in asymptomatic eyes. FEEDBACK: Reason answer is correct or incorrect. a True Neovascularization by itself produces no change in vision, but complications of neovascular proliferation do cause vision loss by bleeding in the eye or retinal detachment
2947_DiabeticRetinopathy_ArticulateQuiz.docx