131/ Incidence, rectal 1.31 cancer, men 72 vs 29 g/day Ptrend:0.33 Age, alcohol consumption, BMI, WHS, 174/ Cancer registry FFQ Incidence, 2.09 energy-adjusted calcium, 2004 Prospective 38 451 colorectal cancer q 5 vs q 1 folate, energy-adjusted COL00299 Cohort, 7.9 years Ptrend:0.08 total fat, energy-adjusted vitamin d, USA Age: 45- energy-adjusted total fiber, family W, history of specific cancer, history of nurses 1.04 per 10 g/day oral contraceptive use, HRT use, nsaid use, physical activity, smoking habits, total energy Bostick, 1994 IWHS, 212/ Driving license Incidence, colon COL00079 Prospective 35 216 cancer Age, energy intake, height, parity, 0.93 USA Cohort, 167 447 FFQ vs total vitamin e intake, total vitamin ≥30.6 ≤13.4 Age: 55-69 g/day e Intake * age, vitamin a Ptrend:0.78 years, supplement W Table Glucose intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, name, Study size Case Exposure RR (95%CI) WCRF Code, Outcome Comparison Adjustment factors characteristics Follow-up ascertainment assessment Ptrend Country (years) McCarl, 2006 IWHS, 954/ Seer registry FFQ Incidence, COL40633 Prospective 35 197 colorectal cancer USA Cohort, 15 years 0.85 vs g Age ≥27.1 ≤11.9 Age: 55-69 years, W
131/ Incidence, rectal cancer, men 72 vs 29 g/day 1.31 Ptrend:0.33 2004 COL00299 USA WHS, Prospective Cohort, Age: 45- W, nurses 174/ 38 451 7.9 years Cancer registry FFQ Incidence, colorectal cancer q 5 vs q 1 2.09 Ptrend:0.08 Age, alcohol consumption, BMI, energy-adjusted calcium, folate, energy-adjusted total fat, energy-adjusted vitamin d, energy-adjusted total fiber, family history of specific cancer, history of oral contraceptive use, HRT use, nsaid use, physical activity, smoking habits, total energy per 10 g/day 1.04 Bostick, 1994 COL00079 USA IWHS, Prospective Cohort, Age: 55-69 years, W 212/ 35 216 167 447 Driving license FFQ Incidence, colon cancer ≥30.6 vs ≤13.4 g/day 0.93 Ptrend:0.78 Age, energy intake, height, parity, total vitamin e intake, total vitamin e Intake * age, vitamin a supplement Table Glucose intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors McCarl, 2006 COL40633 USA IWHS, Prospective Cohort, Age: 55-69 years, W 954/ 35 197 15 years Seer registry FFQ Incidence, colorectal cancer ≥27.1 vs ≤11.9 g 0.85 Age
CUP_colorectal_SLR_2016_RO.docx