Human Health Hazard Summary Table Phthalate Acute Irritation & Repeated Genetic Carcinogenicity Fertility Developmental Toxicity Sensitisation Dose Toxicity Toxicity Toxicity Dimethyl Oral Skin irritation: Rat: Rat, mouse: no Two-generation Two-generation In vitro terephthalate Rat: Minimal Oral Negative in treatment-related Rat: Rat: (DMT) LD50 = 4390 effects NOAEL = 313 Ames test, carcinogenicity. = 5072 NOAEL = 5072 mg/kg > 6590 mg/kg bw/d DNA damage, mg/kg bw/d (TPA) bw/d (TPA) – mg/kg bw Eye irritation: = 636 sister NOAEL = 300 LOAEL = not LOAEL = not Minimal mg/kg bw/d, chromatid mg/kg bw/d established established Dermal effects body weight exchange and ↓ Guinea pig: micronuclei LD50 > 5000 Respiratory assays mg/kg bw irritation: Inhalation No data = 1 In vivo Inhalation mg/m3 Negative in Rat: Skin sex-linked LC50 >6 sensitisation: High doses: recessive mg/L Negative Bladder calculi lethality and and urothelial micronuclei tests hyperplasia.
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Dimethyl terephthalate (DMT) Oral Rat: LD50 = 4390 – > 6590 mg/kg bw Dermal Guinea pig: LD50 > 5000 mg/kg bw Inhalation Rat: LC50 >6 mg/L Skin irritation: Minimal effects Eye irritation: Minimal effects Respiratory irritation: No data Skin sensitisation: Negative Rat: Oral NOAEL = 313 mg/kg bw/d = 636 mg/kg bw/d, ↓ body weight Inhalation = 1 mg/m3 High doses: Bladder calculi and urothelial hyperplasia. In vitro Negative in Ames test, DNA damage, sister chromatid exchange and micronuclei assays In vivo Negative in sex-linked recessive lethality and micronuclei tests Rat, mouse: no treatment-related carcinogenicity. NOAEL = 300 mg/kg bw/d Two-generation Rat: = 5072 mg/kg bw/d (TPA) LOAEL = not established Two-generation Rat: NOAEL = 5072 mg/kg bw/d (TPA) LOAEL = not established
DMT-hazard-assessment.docx