Table 208 Dietary n-3 fatty acid from fish and colorectal cancer risk. Main characteristics of studies included in the CUP SLR meta-analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analyses (years) Age, alcohol, BMI, calendar year, calories intake, endoscopy, energy-adjusted calcium, adjusted folate, energy-adjusted NHS, vitamin d, Song, 2014 Prospective 1 295/ questionnaire, Incidence, vs family history, Mid-point ≥0.3 ≤0.15 COL41015 Cohort, 76 386 national death FFQ 1.03 (0.89-1.20) colorectal cancer g/day fibre, HRT use, exposure USA Age: 30-55 26 years Index, pathology multivitamin W reports and supplement medical records intake, nsaid use, pack years of smoking, physical activity, postmenopausal status, processed meat, red meat Health Self-report, Age, alcohol, Song, 2014 847/ Professionals medical records, Incidence, vs BMI, Mid-point ≥0.41 ≤0.16 COL41016 47 143 1.05 (0.85-1.30) Follow-up Study pathology colorectal cancer g/day endoscopy, exposure USA 24 (HPFS), family energy-adjusted
Table 208 Dietary n-3 fatty acid from fish and colorectal cancer risk. Main characteristics of studies included in the CUP SLR meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analyses Song, 2014 COL41015 USA NHS, Prospective Cohort, Age: 30-55 W 1 295/ 76 386 26 years questionnaire, national death Index, pathology reports and medical records FFQ Incidence, colorectal cancer ≥0.3 vs ≤0.15 g/day 1.03 (0.89-1.20) Age, alcohol, BMI, calendar year, calories intake, endoscopy, energy-adjusted calcium, folate, energy-adjusted vitamin d, family history, fibre, HRT use, multivitamin supplement intake, nsaid use, pack years of smoking, physical activity, postmenopausal status, processed meat, red meat Mid-point exposure Song, 2014 COL41016 USA Health Professionals Follow-up Study (HPFS), 847/ 47 143 24 Self-report, medical records, pathology family Incidence, colorectal cancer ≥0.41 vs ≤0.16 g/day 1.05 (0.85-1.30) Age, alcohol, BMI, endoscopy, energy-adjusted Mid-point exposure adjusted
CUP_colorectal_SLR_2016_RO.docx