Table Vegetable intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Heterogeneity Author, Number of Studies number of Outcome Comparison RR (95%CI) P trend Year studies country, area (I2, p value) cases Meta-analyses Huxley et al, 10 CC 2651 CC Incidence/ High vs. low 0.93 (0.82-1.05) - 19%, p=0.18 2009 8 RC 1005 RC Europe, Asia mortality 0.88 (0.69-1.12) - - 8 CRC 7916 CRC 0.95 (0.86-1.04) - - Aune et al, 15 16057 North Incidence High vs. low 0.91 (0.86-0.96) - 0%, p=0.54 2012 12 - America, Per 100 g/d 0.98 (0.97-0.99) - 0%, p=0.69 Europe, Asia High vs. low 0.87 (0.81-0.94) - 0%, p=0.70 High vs. low 0.94 (0.85-1.04) - 0%, p=0.59 Pooled analyses Koushik, 14 5838 CC North Incidence Quintile 5 vs. 1 0.94 (0.86-1.02) 0.21 NA, p=0.91 2007 America, vs. <100 g/d ≥300 Europe 0.96 (0.84-1.09) 0.24 NA, p=0.33
Table Vegetable intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Meta-analyses Huxley et al, 2009 10 CC 8 RC 8 CRC 2651 CC 1005 RC 7916 CRC Europe, Asia Incidence/ mortality High vs. low 0.93 (0.82-1.05) 0.88 (0.69-1.12) 0.95 (0.86-1.04) - - - 19%, p=0.18 - - Aune et al, 2012 15 12 16057 - North America, Europe, Asia Incidence High vs. low Per 100 g/d High vs. low High vs. low 0.91 (0.86-0.96) 0.98 (0.97-0.99) 0.87 (0.81-0.94) 0.94 (0.85-1.04) - - - - 0%, p=0.54 0%, p=0.69 0%, p=0.70 0%, p=0.59 Pooled analyses Koushik, 2007 14 5838 CC North America, Europe Incidence Quintile 5 vs. 1 ≥300 vs. <100 g/d 0.94 (0.86-1.02) 0.96 (0.84-1.09) 0.21 0.24 NA, p=0.91 NA, p=0.33
CUP_colorectal_SLR_2016_RO.docx