Table 47 Legumes and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Agnoli, 2013 EPIC-Italy, 435/ Cancer registry Incidence, Age, BMI, COL40938 Prospective 45 275 and hospital FFQ colorectal cancer educational Italy Cohort, 11.28 years records level, gender, M/W non-alcoholic Superseded by 23.6-281.4 vs 0.89 (0.70-1.15) beverage intake, Trial, 2013 g/day Ptrend:0.353 physical COL40964 activity, smoking, study centre Age, sex, body EPIC, 773/ Not specified FFQ Incidence, 1.41 weight, centre 2002 Prospective 406 439 colorectal Q 5 vs Q 1 Ptrend:0.54 location, energy COL00950 Cohort, cancer, Superseded by intake, ethanol Europe M/W Bamia, 2013 493/ Women 1.66 intake, height, vs 0-1 g/day ≥26 COL40964 Ptrend:0.35 physical activity at work, 279/ Men 0.95 vs 0-1 g/day ≥23 smoking habits Ptrend:0.72 Fraser, 1999 AHS, Census list FFQ Incidence, colon COL00102 Prospective 34 198 cancer, Superseded by USA Cohort, 6 consumers of Singh, 1998 Age: 25-100 red meat vs 0-1 ≥3 0.33 (0.13-0.83) Unadjusted COL00185 years, times/week (adjusted M/W, results) Seventh-day Adventists Steinmetz, 1994 IWHS, 212/ Incidence, colon SEER COL00178 Prospective 35 216 cancer, vs FFQ ≥1 ≤0 0.95 (0.66-1.36) USA 167 447 Cohort, serving/week Age: 55-69
Table 47 Legumes and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Agnoli, 2013 COL40938 Italy EPIC-Italy, Prospective Cohort, M/W 435/ 45 275 11.28 years Cancer registry and hospital records FFQ Incidence, colorectal cancer 23.6-281.4 vs g/day 0.89 (0.70-1.15) Ptrend:0.353 Age, BMI, educational level, gender, non-alcoholic beverage intake, physical activity, smoking, study centre Superseded by 2013 COL40964 2002 COL00950 Europe EPIC, Prospective Cohort, M/W 773/ 406 439 Not specified FFQ Incidence, colorectal cancer, Q 5 vs Q 1 1.41 Ptrend:0.54 Age, sex, body weight, centre location, energy intake, ethanol intake, height, physical activity at work, smoking habits Superseded by Bamia, 2013 COL40964 493/ Women ≥26 vs 0-1 g/day 1.66 Ptrend:0.35 279/ Men ≥23 vs 0-1 g/day 0.95 Ptrend:0.72 Fraser, 1999 COL00102 USA AHS, Prospective Cohort, Age: 25-100 years, M/W, Seventh-day Adventists 34 198 6 Census list FFQ Incidence, colon cancer, consumers of red meat ≥3 vs 0-1 times/week 0.33 (0.13-0.83) Unadjusted Superseded by Singh, 1998 COL00185 (adjusted results) Steinmetz, 1994 COL00178 USA IWHS, Prospective Cohort, Age: 55-69 212/ 35 216 167 447 SEER FFQ Incidence, colon cancer, ≥1 vs ≤0 serving/week 0.95 (0.66-1.36) Trial,
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