268 Serum/plasma folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Ma, 1997 PHS, 202/ Medical records Plasma Incidence, Age, alcohol COL40780 Nested Case 326 controls measured colorectal cancer consumption, USA Control, 12 years aspirin use, Binary result Age: 40-84 BMI, only. deficient vs years, 1.78 (0.93-3.42) multivitamin Superseded by adequate ng/ml M supplement Lee, 2012 intake, physical COL40917 activity, smoking status Superseded by Glynn, 1996 ATBC, 86/ Cancer registry Serum folate Incidence, colon Weinstein, 2008 COL00161 Nested Case 159 controls cancer 0.73 COL40687. Finland Control, Age: 8 years >2.9 vs ≤ Unadjusted Reviewed in 50-69 years, 2.9ng/ml 50/ Incidence, rectal text, CI M, 90 controls cancer 2.43 mentioned to Male Smokers include 1.0
268 Serum/plasma folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Ma, 1997 COL40780 USA PHS, Nested Case Control, Age: 40-84 years, M 202/ 326 controls 12 years Medical records Plasma measured Incidence, colorectal cancer deficient vs adequate ng/ml 1.78 (0.93-3.42) Age, alcohol consumption, aspirin use, BMI, multivitamin supplement intake, physical activity, smoking status Binary result only. Superseded by Lee, 2012 COL40917 Glynn, 1996 COL00161 Finland ATBC, Nested Case Control, Age: 50-69 years, M, Male Smokers 86/ 159 controls 8 years Cancer registry Serum folate Incidence, colon cancer >2.9 vs ≤ 2.9ng/ml 0.73 Unadjusted Superseded by Weinstein, 2008 COL40687. Reviewed in text, CI mentioned to include 1.0 50/ 90 controls Incidence, rectal cancer 2.43
CUP_colorectal_SLR_2016_RO.docx