Species, Study Duration, Doses NOAEL LOAEL Effects at LOAEL References (mg/kg bw/d) Route (mg/kg (mg/kg bw/d) bw/d) Rat, Sprague-Dawley 0, 25, 100, 250, 1000 NE 25 Lake et al., 1984a* from 25 mg/kg bw/d ↑p.enz.act. 5 males/group 14 days, gavage Rat, Wistar 0, 5, 18, 52, 182, 549 5 18 RIVM, 1992* peroxisomes from 18 mg/kg ↑nb 6 males/group bw/d 2 or 4 weeks, diet Rat, Wistar 0, 250, 500, 1000, 2000 250 500 Khaliq & Srivastava, liver: from 500 mg/kg bw/d ↑relw 5 males/group 1993* 14 days, gavage Rat, Wistar 0, 0.01, 0.025, 0.05, 0.1, 0.5, 42 88 Fukuhara & liver: at 88 mg/kg bw/d ↑relw 5-6 males/group 1.0% (0, 8, 22, 42, 88, 500, 900 Takabatake, 1977* 16 days, diet Rat, F344 0, 2% NE NE & Reddy, ↑relw, ↑p.enz.act. 4-5 males/group 1978* hypolipidemia 3 diet Rat, Sprague-Dawley 0, 2% (0, 900) NE 900 General Motors, and bwg ↓bw 4 males 1982a,b* liver: and relw, peroxisomes, ↑absw ↑nb 3 diet ↑pSER, ↑p.enz.act. kidney: and relw ↑absw and TG only) ↑CHO Rat, F344 0, 0.01, 0.1, 0.6, 1.2, 2.5% (0, NE 11 CMA, 1984*; at 0.01% ↑TG 5 11, 105, 667, 1224, 2101 [M]; Barber et al., 1987 21 days, diet 0, 12, 109, 643, 1197, or 1892 [F])
Species, Study Duration, Route Doses (mg/kg bw/d) NOAEL (mg/kg bw/d) LOAEL (mg/kg bw/d) Effects at LOAEL References Rat, Sprague-Dawley 0, 25, 100, 250, 1000 NE 25 ↑p.enz.act. from 25 mg/kg bw/d Lake et al., 1984a* 5 males/group 14 days, gavage Rat, Wistar 0, 5, 18, 52, 182, 549 5 18 ↑nb peroxisomes from 18 mg/kg RIVM, 1992* 6 males/group bw/d 2 or 4 weeks, diet Rat, Wistar 0, 250, 500, 1000, 2000 250 500 liver: ↑relw from 500 mg/kg bw/d Khaliq & Srivastava, 5 males/group 1993* 14 days, gavage Rat, Wistar 0, 0.01, 0.025, 0.05, 0.1, 0.5, 42 88 liver: ↑relw at 88 mg/kg bw/d Fukuhara & 5-6 males/group 1.0% (0, 8, 22, 42, 88, 500, 900 Takabatake, 1977* 16 days, diet Rat, F344 0, 2% NE NE ↑relw, ↑p.enz.act. & Reddy, 4-5 males/group hypolipidemia 1978* 3 diet Rat, Sprague-Dawley 0, 2% (0, 900) NE 900 ↓bw and bwg General Motors, 4 males 3 diet liver: ↑absw and relw, ↑nb peroxisomes, ↑pSER, ↑p.enz.act. 1982a,b* kidney: ↑absw and relw ↑CHO and TG only) Rat, F344 0, 0.01, 0.1, 0.6, 1.2, 2.5% (0, NE 11 ↑TG at 0.01% CMA, 1984*; 5 11, 105, 667, 1224, 2101 [M]; Barber et al., 1987 21 days, diet 0, 12, 109, 643, 1197, or 1892 [F])
DEHP-hazard-assessment.docx