Table 10 Whole grain intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Cases/ Author, Year, Missing data name, Study size Case Exposure Adjustment WCRF Code, Outcome Comparison RR (95%CI) derived for characteristics Follow-up ascertainment assessment factors Country analysis Total Whole grain intake Incidence, vs 0-31 ≥71 colorectal 0.86 (0.69-1.06) g/day cancer HELGA cohort, Incidence, Prospective colorectal per 25 g 0.94 (0.88-1.01) Cohort, cancer Age: 40-63 Incidence, years vs 0-31 ≥71 colon cancer, 0.76 (0.51-1.13) Includes the g/day men Norwegian Incidence, Women and Kyrø, 2013 cancer, per 25 g 0.96 (0.84-1.09) 1 123/ Cancer Cohort, COL40963 men 108 000 Cancer registry quantitative the Northern Sweden, Incidence, 11 years FFQ Sweden Health Norway proximal vs 0-31 ≥71 0.99 (0.56-1.75) and Disease colon cancer, g/day Study Cohort, men and the Danish Incidence, Diet, Cancer, proximal per 25 g 0.99 (0.82-1.20) and Health colon cancer, cohort (all part men of EPIC) Incidence, vs 0-31 ≥71 distal colon 0.65 (0.37-1.18) g/day cancer, men Incidence, distal colon per 25 g 0.95 (0.79-1.15) cancer, men
Table 10 Whole grain intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Adjustment factors Missing data derived for analysis Kyrø, 2013 COL40963 Sweden, Norway HELGA cohort, Prospective Cohort, Age: 40-63 years Includes the Norwegian Women and Cancer Cohort, the Northern Sweden Health and Disease Study Cohort, and the Danish Diet, Cancer, and Health cohort (all part of EPIC) 1 123/ 108 000 11 years Cancer registry FFQ Total Whole grain intake Incidence, colorectal cancer ≥71 vs 0-31 g/day 0.86 (0.69-1.06) Incidence, colorectal cancer per 25 g 0.94 (0.88-1.01) Incidence, colon cancer, men ≥71 vs 0-31 g/day 0.76 (0.51-1.13) Incidence, cancer, men per 25 g 0.96 (0.84-1.09) Incidence, proximal colon cancer, men ≥71 vs 0-31 g/day 0.99 (0.56-1.75) Incidence, proximal colon cancer, men per 25 g 0.99 (0.82-1.20) Incidence, distal colon cancer, men ≥71 vs 0-31 g/day 0.65 (0.37-1.18) Incidence, distal colon cancer, men per 25 g 0.95 (0.79-1.15) analysis quantitative
CUP_colorectal_SLR_2016_RO.docx