Table 337 Waist to hip ratio and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Cases/ Author, Year, Inclusion/ name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison exclusion characteristics Follow-up ascertainment assessment Ptrend factors Country reasons Age, alcohol, aspirin use, WHI, Self-report smoking, HRT Kabat, 2015 Prospective 1 908/ verified by Incidence, use, diabetes, No specific COL41034 Cohort, 143 901 medical record Measured 1.65 (1.40-1.93) colorectal cancer educational quintile ranges USA Age: 50-79 12.7 years and pathology level, ethnicity, years, report family history of colorectal Age, alcohol, per 1 score 1.12 (1.08-1.16) aspirin use, diabetes, educational WHI, level, ethnicity, Prospective Self-report family history of Heo, 2015 Cohort, 1 904/ verified by colorectal Incidence, Exposure is COL41057 Age: 50-79 144 701 medical record Measured cancer, folate colorectal cancer z-WHR vs 1.18 (1.07-1.30) USA years, 12 years and pathology intake, height, ≥0.75 ≤0.74 W report hormone use, Postmenopausal physical activity, randomisation, red meat intake, smoking MDCS, Brändstedt, Prospective Incidence, 26/ 2014 Cohort, colorectal 1.20 (0.43-3.34) Gene interaction 28 098 Cancer registry vs ≥0.9 ≤0.8 COL41022 Age: 44-74 cancer, men braf Ptrend:0.697 data 18 Sweden years, mutated M/W
Table 337 Waist to hip ratio and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Inclusion/ exclusion reasons Kabat, 2015 COL41034 USA WHI, Prospective Cohort, Age: 50-79 years, 1 908/ 143 901 12.7 years Self-report verified by medical record and pathology report Measured Incidence, colorectal cancer 1.65 (1.40-1.93) Age, alcohol, aspirin use, smoking, HRT use, diabetes, educational level, ethnicity, family history of colorectal No specific quintile ranges Heo, 2015 COL41057 USA WHI, Prospective Cohort, Age: 50-79 years, W Postmenopausal 1 904/ 144 701 12 years Self-report verified by medical record and pathology report Measured Incidence, colorectal cancer per 1 score 1.12 (1.08-1.16) Age, alcohol, aspirin use, diabetes, educational level, ethnicity, family history of colorectal cancer, folate intake, height, hormone use, physical activity, randomisation, red meat intake, smoking Exposure is z-WHR ≥0.75 vs ≤0.74 1.18 (1.07-1.30) Brändstedt, 2014 COL41022 Sweden MDCS, Prospective Cohort, Age: 44-74 years, M/W 26/ 28 098 18 Cancer registry Incidence, colorectal cancer, men braf mutated ≥0.9 vs ≤0.8 1.20 (0.43-3.34) Ptrend:0.697 Gene interaction data analysis
CUP_colorectal_SLR_2016_RO.docx