Cohort III-2 331 Aim: to investigate the effectiveness of hygiene Four out of 331 (1.2%) women seroconverted (Revello et al information in reducing risk of CMV infection. in the intervention group compared to 24/315 2015) (7.6%) in the comparison group (delta=6.4%; Population: Pregnant women at risk of primary 95%CI 3.2 to 9.6; P<0.001). There were three CMV infection for personal/occupational reasons. newborns with congenital infection in the Methods: A mixed interventional and intervention group and 8 in the comparison observational controlled study was conducted. In group (1 with cerebral ultrasound the intervention arm, CMV-seronegative women, abnormalities at birth). Ninety-three percent identified at the time of maternal serum screening of women felt hygiene recommendations were for fetal aneuploidy at 11-12 weeks of gestation, worth suggesting to all pregnant women at risk were given hygiene information and prospectively for infection. tested for CMV until birth. The comparison arm This controlled study provides evidence that consisted of women enrolled at delivery who were an intervention based on the identification neither tested for nor informed about CMV during and hygiene counselling of CMV-seronegative pregnancy, and who had a serum sample stored pregnant women significantly prevents at the screening for fetal aneuploidy. By design, maternal infection. groups were homogeneous for age, parity, education, and exposure to at least one risk factor. The primary outcome was CMV seroconversion. Acceptance of hygiene recommendations was a secondary objective and was measured by a self-report.
(Revello et al 2015) Cohort III-2 331 Aim: to investigate the effectiveness of hygiene information in reducing risk of CMV infection. Population: Pregnant women at risk of primary CMV infection for personal/occupational reasons. Methods: A mixed interventional and observational controlled study was conducted. In the intervention arm, CMV-seronegative women, identified at the time of maternal serum screening for fetal aneuploidy at 11-12 weeks of gestation, were given hygiene information and prospectively tested for CMV until birth. The comparison arm consisted of women enrolled at delivery who were neither tested for nor informed about CMV during pregnancy, and who had a serum sample stored at the screening for fetal aneuploidy. By design, groups were homogeneous for age, parity, education, and exposure to at least one risk factor. The primary outcome was CMV seroconversion. Acceptance of hygiene recommendations was a secondary objective and was measured by a self-report. Four out of 331 (1.2%) women seroconverted in the intervention group compared to 24/315 (7.6%) in the comparison group (delta=6.4%; 95%CI 3.2 to 9.6; P<0.001). There were three newborns with congenital infection in the intervention group and 8 in the comparison group (1 with cerebral ultrasound abnormalities at birth). Ninety-three percent of women felt hygiene recommendations were worth suggesting to all pregnant women at risk for infection. This controlled study provides evidence that an intervention based on the identification and hygiene counselling of CMV-seronegative pregnant women significantly prevents maternal infection.
Cytomegalovirus%20evidence%20evaluation%2015Oct18.DOCX