Inflammatory bowel disease Dermatologic manifestations: Erythema nodosum (CD>UC) Pyoderma gangrenosum (UC > CD) Oral ulcers (CD > UC) Hemachromatosis: Inherited (AR) disorder of iron metabolism, resulting in decreased excretion of iron as well as its deposition in various tissues, mainly the (but also the pancreas, brain, testis, and heart) Bronze skin color (“Bronze DM”) Cirrhosis: Skin manifestations: Nail findings ~ (distal nail has an arc of Terry’s nails darkened color note that if this was half way through – the nail, it would called half and half nails or Lindsay’s nails ~ seen in CRF); leukonychia and clubbing Duputyren’s contracture Palmar erythema Petechia Gynecomastia Spider angioma Tuberous sclerosis Key = hamartomas, AD disease Dermatological manifestations: Angiofibromas (adenoma sebaceum) Look like acne Much smaller than neurofibromas Subungual fibromas Phakomas in the eyes Shagreen patches Roughened patches of skin (seen with Ash leaf spots Wood’s lamp) Depigmented patches manifestations: Seizures (West Syndrome) cortical tumors – (subependymal astrocytomas are common) Rhabdomyoma PKD
Inflammatory bowel disease Dermatologic manifestations: Erythema nodosum (CD>UC) Pyoderma gangrenosum (UC > CD) Oral ulcers (CD > UC) Hemachromatosis: Inherited (AR) disorder of iron metabolism, resulting in decreased excretion of iron as well as its deposition in various tissues, mainly the (but also the pancreas, brain, testis, and heart) Bronze skin color (“Bronze DM”) Cirrhosis: Skin manifestations: Nail findings ~ Terry’s nails (distal nail has an arc of darkened color – note that if this was half way through the nail, it would called half and half nails or Lindsay’s nails ~ seen in CRF); leukonychia and clubbing Duputyren’s contracture Palmar erythema Petechia Gynecomastia Spider angioma Tuberous sclerosis Key = hamartomas, AD disease Dermatological manifestations: Angiofibromas (adenoma sebaceum) Look like acne Much smaller than neurofibromas Subungual fibromas Phakomas in the eyes Shagreen patches Roughened patches of skin Ash leaf spots (seen with Wood’s lamp) Depigmented patches manifestations: Seizures (West Syndrome) – cortical tumors (subependymal astrocytomas are common) Rhabdomyoma PKD
Dermatology+Notes.docx