Human Health Hazard Summary Table Phthalate Irritation & Repeated Genetic Carcinogenicity Fertility Developmental Toxicity Sensitisation Dose Toxicity Toxicity Toxicity Di-C6-10- Oral Skin irritation: Rat: In vitro: In vitro: Rat: Two generation Rat: Minimal = not Equivocal in Negative in cell NOAEL = 135 mg/kg bw/d phthalate >2000 effect established mouse transformation LOAEL = 450 mg/kg bw/d, (Di-C6-10 mg/kg bw/d LOAEL (2-gen. lymphoma assay. Rat: seminal vesicle weight ↓ PE) Eye irritation: repro study) = 45 assay NOAEL = 135 Dermal: Minimal In vivo: mg/kg bw/d mg/kg bw/d, ↑ No data effect In vivo: No data LOAEL = 450 and kidney No data weights (F1 f) mg/kg bw/d, litter ↓ Inhalation: Respiratory survival, pup ↓ No data irritation: High doses: pale weight No data livers with lobulation and Skin discolouration, sensitisation: slight cell necrosis No data (m). PP noted. increase; decrease; m: male; f: female; PP: peroxisome proliferation ↑: ↓:
Human Health Hazard Summary Table Phthalate Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Di-C6-10- phthalate (Di-C6-10 PE) Oral Rat: >2000 mg/kg bw/d Dermal: No data Inhalation: No data Skin irritation: Minimal effect Eye irritation: Minimal effect Respiratory irritation: No data Skin sensitisation: No data Rat: = not established LOAEL (2-gen. repro study) = 45 mg/kg bw/d, ↑ and kidney weights (F1 f) High doses: pale livers with lobulation and discolouration, slight cell necrosis (m). PP noted. In vitro: Equivocal in mouse lymphoma assay In vivo: No data In vitro: Negative in cell transformation assay. In vivo: No data Rat: NOAEL = 135 mg/kg bw/d LOAEL = 450 mg/kg bw/d, ↓ seminal vesicle weight Two generation Rat: NOAEL = 135 mg/kg bw/d LOAEL = 450 mg/kg bw/d, ↓ litter survival, ↓ pup weight ↑: increase; ↓: decrease; m: male; f: female; PP: peroxisome proliferation
DiC6-10-PE-hazard-assessment.docx