To determine whether Objective: Cheriyan et al (2012) Inclusion/exclusion criteria Change in management level of evidence: IV MR enterography influenced the Inclusion: histologically confirmed medical an surgical management CD, underwent MR enterography Ireland, single centre 7 patients had normal MR enterography Quality: Q3 POOR of patients with small bowel CD for symptom and disease 50 patients had abnormal MR Comparison: C1: other comparison (no comparison) assessment enterography (5 stricturing, 17 active, 14 N=57 Applicability: P2 limited (unclear) design: Exclusion: Management options both active and structuring) not clearly stated after MR Retrospective, consecutive QUADAS enterography, or occurred after 1 6/7 patients with normal MR enterography month of MR enterography Prospective: no Timing: 01/2007-12/2010 had no change in management Consecutive: unclear/yes 42 patients had a change in management, Explicit selection criteria: yes Patient characteristics: 22 (53%) had medical intervention and 20 Index test: MR enterography Age/Gender: 47% male, median Reference standard: n/a (47%) underwent surgery. age 36 years (range 16-68), prior Test interval in days/weeks: n/a Comparator test: n/a surgery 39 (68%) and ref std well described/reproducible: yes Conclusion: High clinical impact on Tests assessed and independent of ref std: n/a patient management. Patients with Timing interval: n/a abnormal imaging had significantly more Ref std assessed and blinded to other tests: n/a Length of time with changes in management both surgical Routine clinical data available: yes Reference test: n/a disease: 9.5 years (range 1 35) and medical. – Uninterpretable/intermed results reported: no Prior tests: Not stated withdrawals explained: n/a Test interpretation: MR Clinical characteristics: Sufficient data for 2x2 table: n/a enterography evaluated by one Symptoms not stated radiologist with expertise in 68% had previous surgery gastrointestinal imaging. Relevant population: yes Applicable comparator: n/a Applicable intervention: yes
Cheriyan et al (2012) Ireland, single centre N=57 Objective: To determine whether MR enterography influenced the medical an surgical management of patients with small bowel CD design: Retrospective, consecutive Timing: 01/2007-12/2010 Index test: MR enterography Comparator test: n/a Timing interval: n/a Reference test: n/a Test interpretation: MR enterography evaluated by one radiologist with expertise in gastrointestinal imaging. Inclusion/exclusion criteria Inclusion: histologically confirmed CD, underwent MR enterography for symptom and disease assessment Exclusion: Management options not clearly stated after MR enterography, or occurred after 1 month of MR enterography Patient characteristics: Age/Gender: 47% male, median age 36 years (range 16-68), prior surgery 39 (68%) Length of time with disease: 9.5 years (range 1 – 35) Prior tests: Not stated Clinical characteristics: Symptoms not stated 68% had previous surgery Change in management 7 patients had normal MR enterography 50 patients had abnormal MR enterography (5 stricturing, 17 active, 14 both active and structuring) 6/7 patients with normal MR enterography had no change in management 42 patients had a change in management, 22 (53%) had medical intervention and 20 (47%) underwent surgery. Conclusion: High clinical impact on patient management. Patients with abnormal imaging had significantly more changes in management both surgical and medical. level of evidence: IV Quality: Q3 POOR Comparison: C1: other comparison (no comparison) Applicability: P2 limited (unclear) QUADAS Prospective: no Consecutive: unclear/yes Explicit selection criteria: yes Reference standard: n/a Test interval in days/weeks: n/a and ref std well described/reproducible: yes Tests assessed and independent of ref std: n/a Ref std assessed and blinded to other tests: n/a Routine clinical data available: yes Uninterpretable/intermed results reported: no withdrawals explained: n/a Sufficient data for 2x2 table: n/a Relevant population: yes Applicable comparator: n/a Applicable intervention: yes
1190_MRICrohnsDisease_AttA_FinalCAreport_14Jan2014%20accessible.docx