Human Health Hazard Summary Table Phthalate Acute Irritation & Repeated Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Sensitisation Dose Toxicity Toxicity Dimethyl Oral Skin Irritation: Oral Rat: Developmental study In vitro In vitro (DMP) Rat: ME Rat: NOAEL = 1000 Equivocal in bacterial Negative in Insufficient data Rat: LD50 = 2860 mg/kg bw/d. mutation assays mammalian cell NOAEL = 3570 mg/kg 10000 Eye Irritation: transformation assay. bw/d. – mg/kg bw ME LOAEL = 2000 mg/kg Positive in SCE assay bw/d: body weight LOAEL: NE In vivo ↓ Dermal Sensitisation: Negative in Mouse: (>3570 gain. Rat: negative Negative for mg/kg bw/d) chromosomal LD50 = aberration tests initiation or mg/kg promotion activity Maternal effects: Rat: bw Equivocal in a mouse Rat: NOAEL = 840 NOAEL = 1200 lymphoma assay mg/kg bw/d mg/kg bw/d. Inhalation No data LOAEL = 3570 mg/kg LOAEL = 2400 mg/kg In vivo bw/d: nephritis Equivocal in bw/d: liver weight; ↑ ↓ chromosomal body weight gain aberration tests High nephritis, liver weight; liver ↑ ↓ Negative in SCE cholesterol and total assay lipids; liver damage Negative in a dominant lethal assay ME minimal effects; NE not established; SCE sister chromatid exchange – – –
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Dimethyl (DMP) Oral Rat: LD50 = 2860 – 10000 mg/kg bw Dermal Rat: LD50 = mg/kg bw Inhalation No data Skin Irritation: ME Eye Irritation: ME Sensitisation: negative Oral Rat: NOAEL = 1000 mg/kg bw/d. LOAEL = 2000 mg/kg bw/d: ↓ body weight gain. Rat: NOAEL = 1200 mg/kg bw/d. LOAEL = 2400 mg/kg bw/d: nephritis High nephritis, ↑ liver weight; ↓ liver cholesterol and total lipids; liver damage In vitro Equivocal in bacterial mutation assays Positive in SCE assay Negative in chromosomal aberration tests Equivocal in a mouse lymphoma assay In vivo Equivocal in chromosomal aberration tests Negative in SCE assay Negative in a dominant lethal assay In vitro Negative in mammalian cell transformation assay. In vivo Mouse: Negative for initiation or promotion activity Rat: Insufficient data Developmental study Rat: NOAEL = 3570 mg/kg bw/d. LOAEL: NE (>3570 mg/kg bw/d) Maternal effects: Rat: NOAEL = 840 mg/kg bw/d LOAEL = 3570 mg/kg bw/d: ↑ liver weight; ↓ body weight gain ME – minimal effects; NE – not established; SCE – sister chromatid exchange
DMP-hazard-asssessment.docx