Table Glycemic load and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analysis (years) Sex, alcohol Sieri, 2015 EPIC, 426/ Cancer registry FFQ Incidence, 1.43 (0.94-2.18) intake, BMI, COL41035 Prospective 47 749 and hospital colorectal cancer 191 vs 125 Ptrend:0.153 calcium intake, Italy Cohort, 11.7 years discharge educational M/W records 314/ Incidence, colon 1.60 (0.98-2.60) level, energy, 191 vs 125 cancer Ptrend:0.071 folate intake, Distribution of non-alcohol person-years 107/ Incidence, rectal energy, physical cancer activity, 1.03 (0.45-2.37) 191 vs 125 saturated fat Ptrend:0.769 intake, smoking status Age, birth year, Li, 2011 SWHS, 475/ Cancer registry Dietary recall Incidence, 0.94 (0.71-1.24) BMI, COL40806 Prospective 73 061 and medical colorectal cancer 225.9 vs 159.7 Ptrend:0.84 educational Cohort, 9.1 years records level, family Age: 40-70 287/ Incidence, colon 0.92 (0.64-1.32) history of years, 225.9 vs 159.7 cancer Ptrend:0.45 colorectal W cancer, HRT 188/ Incidence, rectal use, income, cancer 0.99 (0.64-1.52) physical 225.9 vs 159.7 Ptrend:0.55 activity, total energy Bao, 2010 HPFS+NHS, 1 420/ Incidence, FFQ 0.92 (0.77-1.11) COL40837 Prospective 132 886 colorectal 745 vs 547 Ptrend:0.17 USA Cohort, cancer, women certificate/ M/W medical records 1 067/ Incidence, 0.86 (0.70-1.07) 745 vs 547 cancer, women Ptrend:0.09
Table Glycemic load and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analysis Sieri, 2015 COL41035 Italy EPIC, Prospective Cohort, M/W 426/ 47 749 11.7 years Cancer registry and hospital discharge records FFQ Incidence, colorectal cancer 191 vs 125 1.43 (0.94-2.18) Ptrend:0.153 Sex, alcohol intake, BMI, calcium intake, educational level, energy, folate intake, non-alcohol energy, physical activity, saturated fat intake, smoking status Distribution of person-years 314/ Incidence, colon cancer 191 vs 125 1.60 (0.98-2.60) Ptrend:0.071 107/ Incidence, rectal cancer 191 vs 125 1.03 (0.45-2.37) Ptrend:0.769 Li, 2011 COL40806 SWHS, Prospective Cohort, Age: 40-70 years, W 475/ 73 061 9.1 years Cancer registry and medical records Dietary recall Incidence, colorectal cancer 225.9 vs 159.7 0.94 (0.71-1.24) Ptrend:0.84 Age, birth year, BMI, educational level, family history of colorectal cancer, HRT use, income, physical activity, total energy 287/ Incidence, colon cancer 225.9 vs 159.7 0.92 (0.64-1.32) Ptrend:0.45 188/ Incidence, rectal cancer 225.9 vs 159.7 0.99 (0.64-1.52) Ptrend:0.55 Bao, 2010 COL40837 USA HPFS+NHS, Prospective Cohort, M/W 1 420/ 132 886 certificate/ medical records FFQ Incidence, colorectal cancer, women 745 vs 547 0.92 (0.77-1.11) Ptrend:0.17 1 067/ Incidence, cancer, women 745 vs 547 0.86 (0.70-1.07) Ptrend:0.09
CUP_colorectal_SLR_2016_RO.docx