Table 290 Heme-iron and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Cases/ Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Age, sex, Incidence, 1.27 (0.86-1.69) alcohol colorectal 644/ consumption, cancer, kras 4 026 per 1 mg/day BMI, energy negative 7.3 years intake, family Netherlands 1.35 (0.93–1.94) history of Only has Kras positive Cohort Study on colorectal interaction Diet and Cancer cancer, meat results. Incidence, colon Gilsing, 2013 Cancer registry (NLCS), intake, Superseded by 1.31 (0.92–1.87) cancer, kras COL40987 and pathology FFQ Case Cohort, Balder, 2006 435 negative per 1 mg/day Netherlands register Age: 55-69 physical COL40622 1.43 (0.98–2.09) years, activity, (higher number Kras positive M/W physical cases) Incidence, rectal 1.41 (0.85–2.35) activity, cancer, kras processed meat, 140 negative per 1 mg/day smoking, 0.58 (0.27–1.25) vegetable Kras positive consumption Incidence, colorectal EPIC-Norfolk, per 1 sd units 1.64 (0.97-2.75) cancer, gc:at Prospective Gay, 2012 185/ Case-only study mutations Cohort, 7-day dietary Age, sex, COL40920 25 636 Cancer registry with interaction Age: 45-79 recalls smoking Apc promoter UK 11 years results years, methylation per 1 sd units 1.13 (0.79-1.62) M/W ≥20% Apc mutations per 1 sd units 1.50 (1.09-2.09)
Table 290 Heme-iron and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Gilsing, 2013 COL40987 Netherlands Netherlands Cohort Study on Diet and Cancer (NLCS), Case Cohort, Age: 55-69 years, M/W 644/ 4 026 7.3 years Cancer registry and pathology register FFQ Incidence, colorectal cancer, kras negative Kras positive per 1 mg/day 1.27 (0.86-1.69) 1.35 (0.93–1.94) Age, sex, alcohol consumption, BMI, energy intake, family history of colorectal cancer, meat intake, physical activity, physical activity, processed meat, smoking, vegetable consumption Only has interaction results. Superseded by Balder, 2006 COL40622 (higher number cases) 435 Incidence, colon cancer, kras negative Kras positive per 1 mg/day 1.31 (0.92–1.87) 1.43 (0.98–2.09) 140 Incidence, rectal cancer, kras negative Kras positive per 1 mg/day 1.41 (0.85–2.35) 0.58 (0.27–1.25) Gay, 2012 COL40920 UK EPIC-Norfolk, Prospective Cohort, Age: 45-79 years, M/W 185/ 25 636 11 years Cancer registry 7-day dietary recalls Incidence, colorectal cancer, gc:at mutations per 1 sd units 1.64 (0.97-2.75) Age, sex, smoking Case-only study with interaction results Apc promoter methylation ≥20% per 1 sd units 1.13 (0.79-1.62) Apc mutations per 1 sd units 1.50 (1.09-2.09) analysis
CUP_colorectal_SLR_2016_RO.docx