Human Health Hazard Summary Table Phthalate Repeated Dose Toxicity Carcinogenicity Fertility Acute Irritation & Genetic Developmental Toxicity Toxicity Toxicity Di-C9-11- Oral Skin irritation: Rat: In No data Rat: Rat: alkyl Rat: Negative NOAEL = 500 mg/kg Negative in NOAEL = 1000 NOAEL = 250 mg/kg phthalate LD50 >6200 bw/d, bacterial mg/kg bw/d bw/d (Di-C9-11 Eye irritation: (2-gen. repro study) mutation LOAEL: not LOAEL = 500 mg/kg – Negative established bw/d, PE) mg/kg bw = 1000 mg/kg bw/d, ↑ In vivo: liver weight in young rats, skeletal variations ↑ Dermal: Respiratory No data (lumbar ribs) liver histopathological No data irritation: changes and body ↓ No data weights in mature rats, ↑ Inhalation: in palmitoyl CoA oxidase No data Skin activity. sensitisation: Negative increase; decrease ↑: ↓:
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Di-C9-11- alkyl phthalate (Di-C9-11 PE) Oral Rat: LD50 >6200 – mg/kg bw Dermal: No data Inhalation: No data Skin irritation: Negative Eye irritation: Negative Respiratory irritation: No data Skin sensitisation: Negative Rat: NOAEL = 500 mg/kg bw/d, (2-gen. repro study) = 1000 mg/kg bw/d, ↑ liver weight in young rats, liver histopathological changes and ↓ body weights in mature rats, ↑ in palmitoyl CoA oxidase activity. In Negative in bacterial mutation In vivo: No data No data Rat: NOAEL = 1000 mg/kg bw/d LOAEL: not established Rat: NOAEL = 250 mg/kg bw/d LOAEL = 500 mg/kg bw/d, ↑ skeletal variations (lumbar ribs) ↑: increase; ↓: decrease
DiC9-11-PE-hazard-assessment.docx