smoking, vitamin c Age, alcohol, Shin, 2006 SWHS, 283/ Follow up FFQ Incidence, vs 0-53.4 1.10 (0.70-1.60) ≥127.2 calories intake, COL40665 Prospective 73 314 survey/cancer colorectal cancer mg/day Ptrend:0.681 educational China Cohort, 5.74 level, family Age: 40-70 statistics registry Distribution of 129/ Incidence, colon vs 0-53.4 1.00 (0.50-1.90) ≥127.2 history of years, person-years by cancer mg/day Ptrend:0.976 colorectal W exposure cancer, 91/ Incidence, rectal categories. menopausal cancer of status, exposure multivitamin vs 0-53.4 1.20 (0.60-2.40) ≥127.2 categories. supplement mg/day Ptrend:0.662 intake, physical activity, smoking status Sellers, 1998 IWHS, 180/ SEER registry Incidence, colon COL01974 Prospective 35 216 FFQ cancer, no vs 0.80 (0.60-1.20) ≥168.4 ≤115 Distribution of Age, history of USA Cohort, 10 family history of mg/day Ptrend:0.3 by polyps, total Age: 55-69 crc exposure energy intake years, categories. 61/ Family history vs 1.10 (0.50-2.20) ≥168.4 ≤115 W, of crc mg/day Ptrend:0.8 Postmenopausal Shibata, 1992 Leisure 105/ Community FFQ Incidence, COL00740 Cohort, 11 580 registry cancer, women vs 0-155 0.61 (0.38-0.99) ≥225 USA Prospective 70 159 mg/day Ptrend:<0.05 Mid-points of Cohort, Age, smoking exposure M/W, habits 97/ Men categories. retirement vs 0-145 ≥210 community, 1.15 (0.70-1.88) mg/day upper middle social class
smoking, vitamin c Shin, 2006 COL40665 China SWHS, Prospective Cohort, Age: 40-70 years, W 283/ 73 314 5.74 Follow up survey/cancer statistics registry FFQ Incidence, colorectal cancer ≥127.2 vs 0-53.4 mg/day 1.10 (0.70-1.60) Ptrend:0.681 Age, alcohol, calories intake, educational level, family history of colorectal cancer, menopausal status, multivitamin supplement intake, physical activity, smoking status Distribution of person-years by exposure categories. of exposure categories. 129/ Incidence, colon cancer ≥127.2 vs 0-53.4 mg/day 1.00 (0.50-1.90) Ptrend:0.976 91/ Incidence, rectal cancer ≥127.2 vs 0-53.4 mg/day 1.20 (0.60-2.40) Ptrend:0.662 Sellers, 1998 COL01974 USA IWHS, Prospective Cohort, Age: 55-69 years, W, Postmenopausal 180/ 35 216 10 SEER registry FFQ Incidence, colon cancer, no family history of crc ≥168.4 vs ≤115 mg/day 0.80 (0.60-1.20) Ptrend:0.3 Age, history of polyps, total energy intake Distribution of by exposure categories. 61/ Family history of crc ≥168.4 vs ≤115 mg/day 1.10 (0.50-2.20) Ptrend:0.8 Shibata, 1992 COL00740 USA Leisure Cohort, Prospective Cohort, M/W, retirement community, upper middle social class 105/ 11 580 70 159 Community registry FFQ Incidence, cancer, women ≥225 vs 0-155 mg/day 0.61 (0.38-0.99) Ptrend:<0.05 Age, smoking habits Mid-points of exposure categories. 97/ Men ≥210 vs 0-145 mg/day 1.15 (0.70-1.88)
CUP_colorectal_SLR_2016_RO.docx