WHI, Age, income, Prospective physical Cohort, activity, race, Hartz, 2012 1 181/ Age: 50-79 Incidence, colon treatment No Confidence COL40901 141 652 Measured per 1 sd units 1.15 years, cancer allocation, Intervals USA 8 years W, alcohol, Post- education, region, smoking Incidence, per 5 kg/m2 1.28 (1.12-1.45) 550/ Only has gene colorectal NLCS, 4 654 interactions 1.40 (1.09-1.80) cancer, braf Q4 vs Q1 Hughes, 2012 Case Cohort, 7 Cancer registry results Ptrend:<0.001 wildtype COL40943 Age: 55-69 and pathology Self-reported Sex, ethnicity Netherlands years, database Hughes, 2011 per 5 kg/m2 1.22 (1.08-1.39) M/W COL40895 544/ Ms-stable 1.33 (1.03-1.70) used instead Q4 vs Q1 Ptrend:0.04 Incidence, per 5 kg/m2 1.10 (1.00-1.22) MCCS, 495/ Height (cm), colorectal 1.31 (1.01-1.71) Prospective 40 154 Cancer weight (kg) and cancer, Q4 vs Q1 Hughes, 2012 Only has gene Ptrend:0.04 Cohort, registry/death waist stable COL40944 Sex, ethnicity interactions Age: 27-75 records/national circumference Australia results per 5 kg/m2 1.10 (0.99-1.21) years, death index (cm) were 487/ Braf wildtype M/W measured 1.35 (1.03-1.78) Q4 vs Q1 Ptrend:0.04 Kuchiba, 2012 NHS, 536/ Questionnaire Age, aspirin use, Superseded by Incidence, 30 vs 18.5-22.9 1.61 (1.22-2.13) COL40903 Prospective 109 051 and mortality Self-reported calcium, energy Morikawa, 2013 colorectal cancer kg/m2 Ptrend:0.001 USA Cohort, 18 years register intake, folate COL40958
Hartz, 2012 COL40901 USA WHI, Prospective Cohort, Age: 50-79 years, W, 1 181/ 141 652 8 years Measured Incidence, colon cancer per 1 sd units 1.15 Age, income, physical activity, race, treatment allocation, alcohol, education, region, smoking No Confidence Intervals Hughes, 2012 COL40943 Netherlands NLCS, Case Cohort, Age: 55-69 years, M/W 550/ 4 654 7 Cancer registry and pathology database Self-reported Incidence, colorectal cancer, braf wildtype per 5 kg/m2 1.28 (1.12-1.45) Sex, ethnicity Only has gene interactions results Hughes, 2011 COL40895 used instead Q4 vs Q1 1.40 (1.09-1.80) Ptrend:<0.001 544/ Ms-stable per 5 kg/m2 1.22 (1.08-1.39) Q4 vs Q1 1.33 (1.03-1.70) Ptrend:0.04 Hughes, 2012 COL40944 Australia MCCS, Prospective Cohort, Age: 27-75 years, M/W 495/ 40 154 Cancer registry/death records/national death index Height (cm), weight (kg) and waist circumference (cm) were measured Incidence, colorectal cancer, per 5 kg/m2 1.10 (1.00-1.22) Sex, ethnicity Only has gene interactions results Q4 vs Q1 1.31 (1.01-1.71) Ptrend:0.04 487/ Braf wildtype per 5 kg/m2 1.10 (0.99-1.21) Q4 vs Q1 1.35 (1.03-1.78) Ptrend:0.04 Kuchiba, 2012 COL40903 USA NHS, Prospective Cohort, 536/ 109 051 18 years Questionnaire and mortality register Self-reported Incidence, colorectal cancer 30 vs 18.5-22.9 kg/m2 1.61 (1.22-2.13) Ptrend:0.001 Age, aspirin use, calcium, energy intake, folate Superseded by Morikawa, 2013 COL40958 stable Post-
CUP_colorectal_SLR_2016_RO.docx