To assess the Objective: Schmidt et al (2010) Inclusion/exclusion criteria Test Accuracy NHMRC level of evidence: IV agreement between MR Inclusion: histologically proven CD, enterography and CT emergency presentation for acute Switzerland, single Bowel wall thickening Quality: Q2 MEDIUM enterography in assessing extent exacerbation centre MR enterography Comparison: CX: comparison of small bowel CD in patients Exclusion: Sensitivity: 84% Specificity: 91% Applicability: P1 applicable design: contraindications for MRI acute or N=57 CT enterography chronic renal failure, lack of proof Prospective Sensitivity: 93% Specificity: 67% QUADAS of CD Patient characteristics: Prospective: yes Not stated Timing: Fistula Consecutive: yes Age/Gender: 69% male, CD confirmed, mean age 33.5 range MR enterography Explicit selection criteria: yes Index test: MR enterography (17-69 years) Sensitivity: 86% Specificity: 93% Reference standard: composite Length of time with CT enterography Valid: yes Comparator test: CT disease: Median 10 years Sensitivity: 89% Specificity: 98% Applied to all patients: yes enterography Not stated. tests: Test interval in days/weeks: Clinical characteristics: Abscess Comparator: same day Timing interval: < 24 hours Not stated MR enterography Ref std: not stated Sensitivity: 79% Specificity: 99% Tests and ref std well described/reproducible: yes Composite of Reference test: surgery, endoscopy and CT enterography Tests assessed and independent of ref std: no follow-up Sensitivity: 83% Specificity: 97% Ref std assessed and blinded to other tests: no Routine clinical data available: yes Test interpretation: 3 Uninterpretable/intermed results reported: no radiologists, independent and Study withdrawals explained: none blind assessments Sufficient data for 2x2 yes Relevant population: yes yes Applicable comparator: Applicable intervention: yes
Schmidt et al (2010) Switzerland, single centre N=57 Objective: To assess the agreement between MR enterography and CT enterography in assessing extent of small bowel CD in patients design: Prospective Timing: Not stated Index test: MR enterography Comparator test: CT enterography Timing interval: < 24 hours Reference test: Composite of surgery, endoscopy and follow-up Test interpretation: 3 radiologists, independent and blind assessments Inclusion/exclusion criteria Inclusion: histologically proven CD, emergency presentation for acute exacerbation Exclusion: contraindications for MRI acute or chronic renal failure, lack of proof of CD Patient characteristics: Age/Gender: 69% male, CD confirmed, mean age 33.5 range (17-69 years) Length of time with disease: Median 10 years tests: Not stated. Clinical characteristics: Not stated Test Accuracy Bowel wall thickening MR enterography Sensitivity: 84% Specificity: 91% CT enterography Sensitivity: 93% Specificity: 67% Fistula MR enterography Sensitivity: 86% Specificity: 93% CT enterography Sensitivity: 89% Specificity: 98% Abscess MR enterography Sensitivity: 79% Specificity: 99% CT enterography Sensitivity: 83% Specificity: 97% NHMRC level of evidence: IV Quality: Q2 MEDIUM Comparison: CX: comparison Applicability: P1 applicable QUADAS Prospective: yes Consecutive: yes Explicit selection criteria: yes Reference standard: composite Valid: yes Applied to all patients: yes Test interval in days/weeks: Comparator: same day Ref std: not stated Tests and ref std well described/reproducible: yes Tests assessed and independent of ref std: no Ref std assessed and blinded to other tests: no Routine clinical data available: yes Uninterpretable/intermed results reported: no Study withdrawals explained: none Sufficient data for 2x2 yes Relevant population: yes Applicable comparator: yes Applicable intervention: yes
1190_MRICrohnsDisease_AttA_FinalCAreport_14Jan2014%20accessible.docx