Table 160 Total alcoholic drinks and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Aleksandrova, EPIC, 728/ Cancer registry Incidence, colon 0.85(0.74-0.97) 2014 Prospective 347 237 men Age, sex, body COL41051 Cohort, 12 years Incidence, fat, diet quality, Europe Age: 25-70 0.99(0.88-1.14) Only included in colon, women educational years, limited vs heavy highest versus physical M/W Incidence, rectal lowest analysis 0.76 (0.64-0.89) activity, cancer, men smoking Incidence, rectal 0.91(0.76-1.09) cancer, women Age, sex, BMI, Shen, 2013 Chinese elderly 944/ Hospital records Questionnaire Mortality, 1.25 (0.68 to educational COL40995 cohort study 66 820 and register colorectal cancer 2.30) level, exercise, HK, 10.5 years High vs never health status, Outcome is Prospective 516/ Men 1.48 (0.80 to housing, mortality Cohort, 2.74) monthly Age: 65- years, expenditure, 428/ Women M/W, Moderate vs 0.46 (0.11 to smoking status Elderly never 1.83) 5-year age- Yang, 2012 CNRPCS, 193/ Annual follow Questionnaire Mortality, vs 1.06 (0.55-2.06) ≥700 COL40922 Prospective 218 189 up by trained colorectal cancer g/week Ptrend:0.5 educational Outcome is Cohort, 15 staff, death level, mortality Age: 40-79 certificate and all drinkers vs 0.90 (0.65-1.24) geographic area, years, symptoms non-drinkers smoking M
Table 160 Total alcoholic drinks and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country name, characteristics Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Aleksandrova, 2014 COL41051 Europe EPIC, Prospective Cohort, Age: 25-70 years, M/W 728/ 347 237 12 years Cancer registry Incidence, colon men limited vs heavy 0.85(0.74-0.97) Age, sex, body fat, diet quality, educational physical activity, smoking Only included in highest versus lowest analysis Incidence, colon, women 0.99(0.88-1.14) Incidence, rectal cancer, men 0.76 (0.64-0.89) Incidence, rectal cancer, women 0.91(0.76-1.09) Shen, 2013 COL40995 Chinese elderly cohort study HK, Prospective Cohort, Age: 65- years, M/W, Elderly 944/ 66 820 10.5 years Hospital records and register Questionnaire Mortality, colorectal cancer High vs never 1.25 (0.68 to 2.30) Age, sex, BMI, educational level, exercise, health status, housing, monthly expenditure, smoking status Outcome is mortality 516/ Men 1.48 (0.80 to 2.74) 428/ Women Moderate vs never 0.46 (0.11 to 1.83) Yang, 2012 COL40922 CNRPCS, Prospective Cohort, Age: 40-79 years, M 193/ 218 189 15 Annual follow up by trained staff, death certificate and symptoms Questionnaire Mortality, colorectal cancer ≥700 vs g/week 1.06 (0.55-2.06) Ptrend:0.5 5-year educational level, geographic area, smoking Outcome is mortality all drinkers vs non-drinkers 0.90 (0.65-1.24) age-
CUP_colorectal_SLR_2016_RO.docx