Author, Year, Study name, Cases Case Treatment/ RR (95%CI) Country Treatment/ Outcome comparison Ptrend name control Gao, 2013 980 men and 64/132 Colonoscopy Any adenoma 0.74 (0.65-0.85) women (> 50 China examination 42/78 |Left colon years) 1 mg/day 0.40 (0.33-0.49) (Colorectal adenoma confirmed no folic acid adenoma adenoma by 16/29 Right colon supplement occurrence colonoscopy 0.77 (0.55-1.09) adenoma or treatment was primary in past 5 without folic outcome) years 8/22 Advanced acid Average 37.8 adenoma 0.67 (0.58-0.76) months of follow-up Figuereido, 2009 Pooled 343/339 Large bowel Adenoma 0.98 (0.82–1.17) US, Canada, UK analyses of 3 endoscopy recurrence P=0.81 Aspirin/Folate Polyp trials: 1,324 and 105/97 Advanced 0.5 or 1.0 mg/ Prevention Study (AFPPS) participants pathology lesions day of folic NHS/HPFS Prevention treatment, review 1.06 (0.81–1.39) acid or Study, United Kingdom 1,308 placebo P=0.65 placebo Colorectal Adenoma Up to 3.5 Prevention (ukCAP) years of treatment Jaszewski, 2008 49 treated, 45 49/45 Colonoscopy Any adenoma Lower number of 5 mg/day USA placebo adenomas/ patient acid for 3 in the intervention
Author, Year, Country name Study name, Cases Treatment/ control Case Outcome Treatment/ comparison RR (95%CI) Ptrend Gao, 2013 China 980 men and women (> 50 years) confirmed no adenoma by colonoscopy in past 5 years Average 37.8 months of follow-up 64/132 Colonoscopy examination (Colorectal adenoma occurrence was primary outcome) Any adenoma 1 mg/day folic acid supplement or treatment without folic acid 0.74 (0.65-0.85) 42/78 |Left colon adenoma 0.40 (0.33-0.49) 16/29 Right colon adenoma 0.77 (0.55-1.09) 8/22 Advanced adenoma 0.67 (0.58-0.76) Figuereido, 2009 US, Canada, UK Aspirin/Folate Polyp Prevention Study (AFPPS) NHS/HPFS Prevention Study, United Kingdom Colorectal Adenoma Prevention (ukCAP) Pooled analyses of 3 trials: 1,324 participants treatment, 1,308 placebo Up to 3.5 years of treatment 343/339 Large bowel endoscopy and pathology review Adenoma recurrence 0.5 or 1.0 mg/ day of folic acid or placebo 0.98 (0.82–1.17) P=0.81 105/97 Advanced lesions 1.06 (0.81–1.39) P=0.65 Jaszewski, 2008 USA 49 treated, 45 placebo 49/45 Colonoscopy Any adenoma 5 mg/day acid for 3 Lower number of adenomas/ patient in the intervention
CUP_colorectal_SLR_2016_RO.docx