A method described by Mols [5], adapted by Baig [6] and subsequently used by Jarral et al. et al. et [7] was used to assess the methodological quality of included studies. This method uses a al. standardised 10-item checklist (Figure 1). Studies scoring were considered to be quality”, a ≥8 “high score between 5-7 was quality”, and a score <5 considered quality”. “moderate “poor RESULTS Selected Studies Literature search identified 451 studies, of which 43 [8-50] were selected (Figure 2). Data from these studies is summarized in Tables 1-3 which is available as an online supplement. Study Objectives, Designs and Population The 43 studies included comprised a total of 6865 participants (range 9-803). Twenty-one were prospective cohort [9-16, 21, 22, 28, 29, 32, 35, 36, 40, 42, 44, 45, 48, 50], 6 were retrospective cohort [30, 34, 37, 38, 43, 46], 3 were randomised controlled trials [8, 18, 31], 3 were non-randomised controlled trials [19, 47, 49], 3 were cross-sectional [20, 25, 27], 3 were retrospective cross-sectional [24, 26, 33], 2 were post-approval studies [39, 41], 1 was prospective case-control [17], and 1 was prospective longitudinal [23]. All studies included patients who underwent intervention from 1976 to current. Twenty-six (60.5%) studies originated from Europe, 13 (30.2%) from USA, 4 (9.30%) from Canada, and 1 (2.33%) from Australia. 13 (30.2%) were multicentre studies. To ease reading and improve clarity of results, the above studies were categorised into 3 groups (see online supplement for Tables 1-3): 1. Studies including conventional MV interventions (surgical repair or replacement)
A method described by Mols et al. [5], adapted by Baig et al. [6] and subsequently used by Jarral et al. [7] was used to assess the methodological quality of included studies. This method uses a standardised 10-item checklist (Figure 1). Studies scoring ≥8 were considered to be “high quality”, a score between 5-7 was “moderate quality”, and a score <5 considered “poor quality”. RESULTS Selected Studies Literature search identified 451 studies, of which 43 [8-50] were selected (Figure 2). Data from these studies is summarized in Tables 1-3 which is available as an online supplement. Study Objectives, Designs and Population The 43 studies included comprised a total of 6865 participants (range 9-803). Twenty-one were prospective cohort [9-16, 21, 22, 28, 29, 32, 35, 36, 40, 42, 44, 45, 48, 50], 6 were retrospective cohort [30, 34, 37, 38, 43, 46], 3 were randomised controlled trials [8, 18, 31], 3 were non-randomised controlled trials [19, 47, 49], 3 were cross-sectional [20, 25, 27], 3 were retrospective cross-sectional [24, 26, 33], 2 were post-approval studies [39, 41], 1 was prospective case-control [17], and 1 was prospective longitudinal [23]. All studies included patients who underwent intervention from 1976 to current. Twenty-six (60.5%) studies originated from Europe, 13 (30.2%) from USA, 4 (9.30%) from Canada, and 1 (2.33%) from Australia. 13 (30.2%) were multicentre studies. To ease reading and improve clarity of results, the above studies were categorised into 3 groups (see online supplement for Tables 1-3): 1. Studies including conventional MV interventions (surgical repair or replacement)
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