Table 258 Total folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Author, Year, Study name, size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country Lee, 2011 NHS+HPFS 2299/ Self-reported FFQ Incidence, Age, calendar USA 87891men and and medical colorectal cancer year, pack-years 47290 women records of smoking before age 30 y, physical activity, aspirin dose, height, BMI, family history of colorectal cancer in Superseded by vs parents and ≥800 0.89 (0.74, Pooling Project <250 mcg/d siblings, Kim, 2010 menopausal status and hormone therapy use, history of endoscopy, and intakes of red meat, alcohol, calcium from foods, and total energy. Age, aspirin Schernhammer, NHS-HPFS, 277/ Self-report use, BMI, 2008 Prospective 136 062 Incidence, colon vs Superseded by ≥662 ≤284 verified by 0.80 (0.54-1.19) intakes of COL40729 Cohort, 2 566 968 FFQ cancer, men mcg/day Wei, 2004 medical record calcium, beef, USA M/W methionine,
Table 258 Total folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Lee, 2011 USA NHS+HPFS 2299/ 87891men and 47290 women Self-reported and medical records FFQ Incidence, colorectal cancer ≥800 vs <250 mcg/d 0.89 (0.74, Age, calendar year, pack-years of smoking before age 30 y, physical activity, aspirin dose, height, BMI, family history of colorectal cancer in parents and siblings, menopausal status and hormone therapy use, history of endoscopy, and intakes of red meat, alcohol, calcium from foods, and total energy. Superseded by Pooling Project Kim, 2010 Schernhammer, 2008 COL40729 USA NHS-HPFS, Prospective Cohort, M/W 277/ 136 062 2 566 968 Self-report verified by medical record FFQ Incidence, colon cancer, men ≥662 vs ≤284 mcg/day 0.80 (0.54-1.19) Age, aspirin use, BMI, intakes of calcium, beef, methionine, Superseded by Wei, 2004 analysis
CUP_colorectal_SLR_2016_RO.docx