PARENTERAL LOAEL References NOAEL (mg/kg bw/d) & Endpoint design/Species (mg/kg bw/d) Doses INHALATION (mg/kg bw/d) Mat: NE (Merkle et al., Rat, Wistar Fert: NE 1988*) Mat: 300 25 F/ group Devp: NE (↓ nb live foetuses at 50 mg/m3 but not 300 Fert: 300 GD 6-15 Head-nose 0, 0.01, 0.05, or 0.3 mg/m3; % of resorptions at 50 mg/m3 but not 300 ↑ Devp: 300 mg/litre mg/m3 (0, 10, 50, or 300 mg/m3) 6h/d Rat IV 0, 1.3-1.4, 4.7-5.3 Mat: 4.7-5.3 Mat: NE (Lewandowski et GD 6-15. Fert: 4.7-5.3 Fert: NE al., 1980*) Devp: 4.7-5.3 Devp: NE Rat, Sprague-Dawley IP 0, 4930 and 9860 Mat: NE Mat: (Singh et al., 5/group Fert: NE 1972*) GD 5, 10, and 15 Fert: 4930, implantations ↓ Devp: NE Devp: 4930, foetal wt Rat, Sprague-Dawley ↓ (Peters & Cook, IP 0, 1972, Mat: NE Mat: 1972, dam deaths ↑ GD3, 6, and 9 1973*) Fert: NE Fert: 1972, implantations ↓ Examined at weaning Devp: NE Devp: 1972, nb of weaned pups ↓ M: male; F: female; AGD: anogenital distance; bw: body weight; bwg: body weight gain; nb: number; NE: not established; NR: not reported; Mat: maternal; Fert: fertility; Devp: development; wt: weight
design/Species INHALATION Rat, Wistar 25 F/ group GD 6-15 PARENTERAL Doses (mg/kg bw/d) Head-nose 0, 0.01, 0.05, or 0.3 mg/litre (0, 10, 50, or 300 mg/m3) 6h/d NOAEL (mg/kg bw/d) Mat: 300 Fert: 300 Devp: 300 LOAEL (mg/kg bw/d) & Endpoint Mat: NE Fert: NE Devp: NE (↓ nb live foetuses at 50 mg/m3 but not 300 mg/m3; ↑ % of resorptions at 50 mg/m3 but not 300 mg/m3 References (Merkle et al., 1988*) Rat GD 6-15. Rat, Sprague-Dawley 5/group GD 5, 10, and 15 Rat, Sprague-Dawley GD3, 6, and 9 Examined at weaning IV 0, 1.3-1.4, 4.7-5.3 Mat: 4.7-5.3 Fert: 4.7-5.3 Devp: 4.7-5.3 IP 0, 4930 and 9860 Mat: NE Fert: NE Devp: NE IP 0, 1972, Mat: NE Fert: NE Devp: NE Mat: NE Fert: NE Devp: NE Mat: Fert: 4930, ↓ implantations Devp: 4930, ↓ foetal wt Mat: 1972, ↑ dam deaths Fert: 1972, ↓ implantations Devp: 1972, ↓ nb of weaned pups (Lewandowski et al., 1980*) (Singh et al., 1972*) (Peters & Cook, 1973*) M: male; F: female; AGD: anogenital distance; bw: body weight; bwg: body weight gain; nb: number; NE: not established; NR: not reported; Mat: maternal; Fert: fertility; Devp: development; wt: weight
DEHP-hazard-assessment.docx