Human Health Hazard Summary Table Phthalate Carcinogenicity Fertility Acute Irritation & Repeated Dose Genetic Developmental Toxicity Sensitisation Toxicity Toxicity Toxicity In vitro: No data NOAEL = 250 = 250 Ditridecyl Oral Skin irritation: Rat: phthalate Rat: No data NOAEL = 10 Negative in mg/kg bw/d mg/kg bw/d LOAEL = not LOAEL = not (DTDP) LD50 >2000 mg/kg bw/d bacterial mg/kg bw Eye irritation: LOAEL = 50 mutation and established established No data chromosomal mg/kg bw/d, ↑ Dermal aberration weights, Respiratory tests No data hypertrophy of irritation: centrilobular Inhalation No data In vivo: hepatocytes, ↓ No data No data body weight gain. Skin sensitisation: No data High doses: liver, kidney effects. PP not noted. increase; decrease; PP: peroxisome proliferation ↑: ↓:
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Ditridecyl Oral Skin irritation: Rat: In vitro: No data NOAEL = 250 = 250 phthalate Rat: No data NOAEL = 10 Negative in mg/kg bw/d mg/kg bw/d (DTDP) LD50 >2000 mg/kg bw/d bacterial LOAEL = not LOAEL = not mg/kg bw Eye irritation: LOAEL = 50 mutation and established established No data mg/kg bw/d, ↑ chromosomal Dermal weights, aberration No data Respiratory hypertrophy of tests irritation: centrilobular Inhalation No data hepatocytes, ↓ In vivo: No data body weight gain. No data Skin sensitisation: No data High doses: liver, kidney effects. PP not noted. ↑: increase; ↓: decrease; PP: peroxisome proliferation
DTDP-hazard-assessment.docx