Table Fruit and vegetable intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Heterogeneity Author, Number of Studies number of Outcome Comparison RR (95%CI) P trend Year studies country, area (I2, p value) cases Meta-analyses Aune et al, 11 CRC 11853 North Incidence High vs. low 0.92 (0.86-0.99) - 22%, p=0.24 2012 11 America, Per 100 g/d 0.99 (0.98-1.00) - 38%, p=0.10 11 CC Europe, Asia High vs. low 0.91 (0.84-0.99) - 12.9%, p=0.32 7 RC High vs. low 0.97 (0.86-1.09) - 0%, p=0.65 Pooled analyses Koushik, 14 5838 CC North Incidence Quintile 5 vs. 1 0.91 (0.82-1.01) 0.19 NA, p=0.31 2007 America, vs. <100 ≥400 Europe g/d 0.90 (0.77-1.05) 0.06 NA, p=0.46
Table Fruit and vegetable intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Meta-analyses Aune et al, 2012 11 CRC 11 11 CC 7 RC 11853 North America, Europe, Asia Incidence High vs. low Per 100 g/d High vs. low High vs. low 0.92 (0.86-0.99) 0.99 (0.98-1.00) 0.91 (0.84-0.99) 0.97 (0.86-1.09) - - - - 22%, p=0.24 38%, p=0.10 12.9%, p=0.32 0%, p=0.65 Pooled analyses Koushik, 2007 14 5838 CC North America, Europe Incidence Quintile 5 vs. 1 ≥400 vs. <100 g/d 0.91 (0.82-1.01) 0.90 (0.77-1.05) 0.19 0.06 NA, p=0.31 NA, p=0.46
CUP_colorectal_SLR_2016_RO.docx