2012 Prospective 386 355 registries, WCRF colorectal COL41048 Cohort, 11 years health Insurance score cancer disease at France, Trial, Age: 25-70 records, baseline, Spain, UK, M/W pathology rec & educational Netherlands, active follow up energy intake, Greece, smoking Germany, Intensity, Sweden, smoking status, Denmark, study centre Norway 4 Dietary Guideline Index Score and colorectal cancer risk. Main characteristics of studies identified CUP SLR Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country (years) Dartois, 2014 E3N EPIC- 481/ Self-report Self- Incidence, Age at first child COL41004 64 732 verified by colorectal birth, age at France Prospective 8 years reviewing cancer menarche, Cohort, medical and educational Age: 43-68 pathological e level, family 0.66 (0.45-0.97) W records by Index of 4.5- 5 vs 0- 2 history of cancer Ptrend:0.013 physicians compliance In first degree with the relatives, French and menopausal WHO estrogen use, guidelines menopausal
2012 COL41048 France, Spain, UK, Netherlands, Greece, Germany, Sweden, Denmark, Norway Prospective Cohort, Age: 25-70 M/W 386 355 11 years registries, health Insurance records, pathology rec & active follow up WCRF score colorectal cancer disease at baseline, educational energy intake, smoking Intensity, smoking status, study centre 4 Dietary Guideline Index Score and colorectal cancer risk. Main characteristics of studies identified CUP SLR Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Dartois, 2014 COL41004 France E3N Prospective Cohort, Age: 43-68 W 481/ 64 732 8 years Self-report verified by reviewing medical and pathological records by physicians Index of compliance with the French and WHO guidelines Incidence, colorectal cancer 4.5- 5 vs 0- 2 0.66 (0.45-0.97) Ptrend:0.013 Age at first child birth, age at menarche, educational level, family history of cancer In first degree relatives, menopausal estrogen use, menopausal e EPIC- Trial, Self-
CUP_colorectal_SLR_2016_RO.docx