Patients with suspected Clinical examination MRI pelvis Endoanal ultrasound example from medical to or established fistulising involving patient history, Surgical examination surgery) perianal Crohn’s disease assessment of symptoms, blood tests. Patient outcomes Impact of treatment on symptoms Activity of disease Development of complications Crohn’s disease progression Treatment morbidity Quality of life CT = computer tomography, MRI = magnetic resonance imaging, SBFT = small bowel follow through, TP = true positives, FP = false positives. Review of literature Literature sources and search strategies The medical literature was searched to identify relevant studies and reviews for the period up to November 2013. Searches were conducted via MEDLINE, The Cochrane Library (including Cochrane Reviews, NHS-EED, DARE and HTA), clinical registers and HTA sites (Table 6). Reference lists of the selected studies were manually searched. Table 6: Electronic databases searched Database Period covered MEDLINE via OVID MEDLINE Up to 11 November 2013 The Cochrane Library NHS-EED Cochrane Reviews DARE HTA Clinical Registers Current Controlled Trials Up to 15 November 2013 ControlledTrials.gov Australian New Zealand Clinical Trials Registry WHO International Clinical Trials Registry Platform HTA websites International Network of Agencies for Health Technology Assessment (INAHTA) NHS Centre for Reviews and Dissemination databases The search terms used included bowel’ ‘Crohn’ ‘Crohn’s’ ‘enteritis’‘enterocolitis’ ‘small sepsis’ resonance’ and Search ‘pelvic ‘fistula’‘magnetic ‘MRI’ ‘MRE’ ‘fistulising’ ‘perianal’. terms were confined to the title, abstract or keywords fields. Full details of the search strategies are provided in Appendix B. Title and abstracts were screened by two evaluators for potential relevance and omitted where appropriate. Of those remaining, full text articles were retrieved and examined in more depth. Table 7 provides full details of the a priori inclusion and exclusion criteria used for the studies included for this assessment.
example from medical to surgery) Patient outcomes Impact of treatment on symptoms Activity of disease Development of complications Crohn’s disease progression Treatment morbidity Quality of life Patients with suspected or established fistulising perianal Crohn’s disease Clinical examination involving patient history, assessment of symptoms, blood tests. MRI pelvis Endoanal ultrasound Surgical examination CT = computer tomography, MRI = magnetic resonance imaging, SBFT = small bowel follow through, TP = true positives, FP = false positives. Review of literature Literature sources and search strategies The medical literature was searched to identify relevant studies and reviews for the period up to November 2013. Searches were conducted via MEDLINE, The Cochrane Library (including Cochrane Reviews, NHS-EED, DARE and HTA), clinical registers and HTA sites (Table 6). Reference lists of the selected studies were manually searched. Table 6: Electronic databases searched Database Period covered MEDLINE via OVID MEDLINE Up to 11 November 2013 The Cochrane Library NHS-EED Cochrane Reviews DARE HTA Up to 15 November 2013 Clinical Registers Current Controlled Trials ControlledTrials.gov Australian New Zealand Clinical Trials Registry WHO International Clinical Trials Registry Platform HTA websites International Network of Agencies for Health Technology Assessment (INAHTA) NHS Centre for Reviews and Dissemination databases The search terms used included ‘Crohn’ ‘Crohn’s’ ‘enteritis’‘enterocolitis’ ‘small bowel’ ‘pelvic sepsis’ ‘fistula’‘magnetic resonance’ ‘MRI’ ‘MRE’ ‘fistulising’ and ‘perianal’. Search terms were confined to the title, abstract or keywords fields. Full details of the search strategies are provided in Appendix B. Title and abstracts were screened by two evaluators for potential relevance and omitted where appropriate. Of those remaining, full text articles were retrieved and examined in more depth. Table 7 provides full details of the a priori inclusion and exclusion criteria used for the studies included for this assessment.
1190_MRICrohnsDisease_AttA_FinalCAreport_14Jan2014%20accessible.docx