B . Randomized controlled trials with colorectal adenomas as primary endpoint published after the 2007 WCRF Expert Report (Only the most recent publication of a or that with the larger number of cases is shown). Pattern of diet ( Low fat, high fruits and vegetables) Author, Year, Cases Case RR (95%CI) Study name, Treatment/ Treatment/ Country Outcome characteristics comparison Study name control Ptrend Randomised Control Full Adenoma 0.65 947 control colonoscopies recurrence 65/347 0.92) intervention group, 958 intervention at baseline, (20% energy group their 1-year intake from Age at least 35- years, visit, and the fats, at least M/W end of the Sansbury, 2009 18 g of fibre with at one Polyp Prevention and 3.5 histologically intervention, USA servings of confirmed colorectal about 4 years Advanced 0.44 (0.18- 7/66 fruits and adenoma identified after adenoma 1.05) vegetables 4 years follow-up per 1,000 kcal) vs no intervention
B . Randomized controlled trials with colorectal adenomas as primary endpoint published after the 2007 WCRF Expert Report (Only the most recent publication of a or that with the larger number of cases is shown). Pattern of diet ( Low fat, high fruits and vegetables) Author, Year, Country Study name Study name, characteristics Cases Treatment/ control Case Outcome Treatment/ comparison RR (95%CI) Ptrend Sansbury, 2009 Polyp Prevention USA Randomised Control 947 control group, 958 intervention group Age at least 35- years, M/W with at one histologically confirmed colorectal adenoma identified 4 years follow-up 65/347 Full colonoscopies at baseline, their 1-year visit, and the end of the intervention, about 4 years after Adenoma recurrence intervention (20% energy intake from fats, at least 18 g of fibre and 3.5 servings of fruits and vegetables per 1,000 kcal) vs no intervention 0.65 0.92) 7/66 Advanced adenoma 0.44 (0.18- 1.05)
CUP_colorectal_SLR_2016_RO.docx