Table Garlic and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Number of Studies Heterogeneity Author, Year cohort number of Outcome Comparison RR (95%CI) P country, area (I2, p value) studies cases Meta-analysis North Colorectal Heine Bröring, 2 802 1.24(0.99-1.54) 0%, 0.36 America, Highest vs Lowest 2015 cancer Europe Table Garlic and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country Age, alcohol Meng, 2013 NHS, 634/ Questionnaire Incidence, Biennial 1.13 (0.78-1.64) consumption, COL40930 Prospective 76 208 proximal cancer up Ptrend:0.33 aspirin use, beef, Cohort, 24 years questionnaires pork or lamb as Age: 30-55 and medical 397/ Incidence, distal 1.39 (0.88-2.20) a main dish, years, records cancer Ptrend:0.30 BMI, calcium W, vs ≥1/day Intake, nurses 285/ Incidence, rectal 1.14 (0.64-2.03) endoscopy, cancer Ptrend:0.68 energy, folate, 1 339 Incidence, 1.21 (0.94-1.57) history of colorectal cancer Ptrend:0.14 colorectal cancer, HRT 1 054/ Incidence, colon 1.23 (0.92-1.64) use, physical cancer Ptrend:0.15
Table Garlic and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies number of cases Studies country, area Outcome Comparison RR (95%CI) P Heterogeneity (I2, p value) Meta-analysis Heine Bröring, 2015 2 802 North America, Europe Colorectal cancer Highest vs Lowest 1.24(0.99-1.54) 0%, 0.36 Table Garlic and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Meng, 2013 COL40930 NHS, Prospective Cohort, Age: 30-55 years, W, nurses 634/ 76 208 24 years Biennial questionnaires and medical records Questionnaire Incidence, proximal cancer ≥1/day vs 1.13 (0.78-1.64) Ptrend:0.33 Age, alcohol consumption, aspirin use, beef, pork or lamb as a main dish, BMI, calcium Intake, endoscopy, energy, folate, history of colorectal cancer, HRT use, physical 397/ Incidence, distal cancer 1.39 (0.88-2.20) Ptrend:0.30 285/ Incidence, rectal cancer 1.14 (0.64-2.03) Ptrend:0.68 1 339 Incidence, colorectal cancer 1.21 (0.94-1.57) Ptrend:0.14 1 054/ Incidence, colon cancer 1.23 (0.92-1.64) Ptrend:0.15 up
CUP_colorectal_SLR_2016_RO.docx