Table 78 Red meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Studies Number of Heterogeneity Author, Year number of country, Outcome Comparison RR (95%CI) P trend cohort studies (I2, p value)* cases area Pooled analysis 7 nested studies North HPFS, MEC, NHS, 3 488 Colorectal cancer 1.05 (0.94–1.18) Kantor, 2014 Per 1 serving/day America PHS, PLCO, VITAL, WHI 5 nested studies Ananthakrishnan North 2564 Colorectal cancer 1.06 (0.90–1.24) Highest vs lowest 2014 HPFS, NHS, PLCO, America VITAL, WHI 7 0.91 (0.66–1.24) vs <5 g/day ≥50 Colorectal cancer 0.89 Guernsey Study, Per 50g/day 1.01 (0.84–1.22) 579 cases EPIC- Norfolk, 0.92 (0.62–1.35) vs <5 g/day ≥50 1996 Colon cancer 0.72 UK EPIC-Oxford, Per 50g/day 1.04 (0.83–1.31) controls Spencer, 2010 NSHD, Oxford 0.87 (0.50–1.52) vs <5 g/day ≥50 Rectal cancer 0.78 Vegetarian Per 50g/day 0.96 (0.70–1.31) Oxford Vegetarian
Table 78 Red meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value)* Pooled analysis Kantor, 2014 7 nested studies HPFS, MEC, NHS, PHS, PLCO, VITAL, WHI 3 488 North America Colorectal cancer Per 1 serving/day 1.05 (0.94–1.18) 2014 5 nested studies HPFS, NHS, PLCO, VITAL, WHI 2564 North America Colorectal cancer Highest vs lowest 1.06 (0.90–1.24) Spencer, 2010 7 Guernsey Study, EPIC- Norfolk, EPIC-Oxford, NSHD, Oxford Vegetarian Oxford Vegetarian 579 cases 1996 controls UK Colorectal cancer ≥50 vs <5 g/day Per 50g/day 0.91 (0.66–1.24) 1.01 (0.84–1.22) 0.89 Colon cancer ≥50 vs <5 g/day Per 50g/day 0.92 (0.62–1.35) 1.04 (0.83–1.31) 0.72 Rectal cancer ≥50 vs <5 g/day Per 50g/day 0.87 (0.50–1.52) 0.96 (0.70–1.31) 0.78 Ananthakrishnan
CUP_colorectal_SLR_2016_RO.docx