Table 54 Red and processed meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Number of Total Studies Heterogeneity Author, Year cohort number of Outcome Comparison RR (95%CI) P trend country, area (I2, p value) studies cases Pooled analysis Colorectal 0.88 (0.65–1.20) 0.68 cancer 0.97 (0.84–1.12) 579 cases vs <25 g/day ≥75 0.88 (0.60–1.29) 7 1996 Spencer, 2010 UK Colon cancer 0.74 1.03 (0.86–1.24) Per 50g/day controls 0.83 (0.49–1.42) Rectal cancer 0.22 0.85 (0.66–1.10) Meta-analysis Colorectal, Europe, Asia colon and 27 33.6%, 0.01 1.11(1.03-1.19) Alexander, 2015 and Highest vs lowest rectal cancer America combined Colorectal Highest vs lowest 1.22 (1.11-1.34) 10 11358 56%, 0.01 Europe, Asia cancer Per 100g/day 1.14(1.04-1.24) Chan, 2011 and North 8 5426 cancer 60%, 0.02 Per 100g/day 1.25 (1.10–1.43) America 5 2091 Rectal cancer 18%, 0.30 1.31 (1.13–1.52) Per 100g/day
Table 54 Red and processed meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Pooled analysis Spencer, 2010 7 579 cases 1996 controls UK Colorectal cancer ≥75 vs <25 g/day Per 50g/day 0.88 (0.65–1.20) 0.97 (0.84–1.12) 0.68 Colon cancer 0.88 (0.60–1.29) 1.03 (0.86–1.24) 0.74 Rectal cancer 0.83 (0.49–1.42) 0.85 (0.66–1.10) 0.22 Meta-analysis Alexander, 2015 27 Europe, Asia and America Colorectal, colon and rectal cancer combined Highest vs lowest 1.11(1.03-1.19) 33.6%, 0.01 Chan, 2011 10 11358 Europe, Asia and North America Colorectal cancer Highest vs lowest 1.22 (1.11-1.34) 56%, 0.01 Per 100g/day 1.14(1.04-1.24) 8 5426 cancer Per 100g/day 1.25 (1.10–1.43) 60%, 0.02 5 2091 Rectal cancer Per 100g/day 1.31 (1.13–1.52) 18%, 0.30
CUP_colorectal_SLR_2016_RO.docx