Health Hazard Summary Table Phthalate Genetic Toxicity Carcinogenicity Fertility Acute Irritation & Repeated Developmental Toxicity Sensitisation Dose Toxicity Toxicity Diundecyl Oral Skin irritation: Oral In vitro: No data No data No data phthalate Rat: Negative Rat: Negative in (DUP) LD50 NOAEL = 282 bacterial mutation >15800 Eye irritation: mg/kg bw/d and lymphoma assays mg/kg bw Minimal effects LOAEL: 1145 Dermal Respiratory irritation: mg/kg bw/d, In vivo: No data No data No data dose related ↑ liver weights. Inhalation Skin sensitisation: Rat: Negative High doses: ↑ LC50 >1.8 liver and mg/L/6h kidney weights. PP noted. increase; decrease; PP: peroxisome proliferation ↑: ↓:
Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Diundecyl phthalate (DUP) Oral Rat: LD50 >15800 mg/kg bw Dermal No data Inhalation Rat: LC50 >1.8 mg/L/6h Skin irritation: Negative Eye irritation: Minimal effects Respiratory irritation: No data Skin sensitisation: Negative Oral Rat: NOAEL = 282 mg/kg bw/d LOAEL: 1145 mg/kg bw/d, dose related ↑ liver weights. High doses: ↑ liver and kidney weights. PP noted. In vitro: Negative in bacterial mutation and lymphoma assays In vivo: No data No data No data No data ↑: increase; ↓: decrease; PP: peroxisome proliferation
DUP-hazard-assessment.docx