5.6.3 Calcium and Vitamin D Author, Year, Case Study name, Treatment/ RR (95%CI) Country Treatment/ Outcome characteristics comparison Ptrend Study name control Baron, 2015 Patients with past diagnosed 438/442 Colonoscopy Adenomas Vitamin D vs 0.99 (0.89–1.09) adenomas and no known USA was (primary end no Vitamin D colorectal polyps remaining Calcium Polyp anticipated to point) 345/362 Calcium vs 0.95 (0.85–1.06) after complete colonoscopy Prevention Study be performed no calcium Partial 2x2 factorial design: after 3 or 5 2259 participants to receive 259/259 Calcium and 1.01 (0.88–1.15) years daily vitamin D3 (1000 IU), Vit D vs calcium as carbonate (1200 calcium alone mg), both, or neither 174/183 Calcium and 0.93 (0.80–1.08) Vitamin D vs placebo
5.6.3 Calcium and Vitamin D Author, Year, Country Study name Study name, characteristics Treatment/ control Case Outcome Treatment/ comparison RR (95%CI) Ptrend Baron, 2015 USA Calcium Polyp Prevention Study Patients with past diagnosed adenomas and no known colorectal polyps remaining after complete colonoscopy Partial 2x2 factorial design: 2259 participants to receive daily vitamin D3 (1000 IU), calcium as carbonate (1200 mg), both, or neither 438/442 Colonoscopy was anticipated to be performed after 3 or 5 years Adenomas (primary end point) Vitamin D vs no Vitamin D 0.99 (0.89–1.09) 345/362 Calcium vs no calcium 0.95 (0.85–1.06) 259/259 Calcium and Vit D vs calcium alone 1.01 (0.88–1.15) 174/183 Calcium and Vitamin D vs placebo 0.93 (0.80–1.08)
CUP_colorectal_SLR_2016_RO.docx