237 Supplemental vitamin E and colorectal cancer risk. Main characteristics of cohort studies identified in the CUP SLR Cases/ Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country (years) Roswall, 2010 DCH, 465 Cancer registry FFQ Incidence, Age, alcohol COL40797 Prospective 56 332 cancer intake, beta Denmark Cohort, 10.6 years carotene, BMI, Age: 50-64 educational M/W level, folate intake, hormone use, physical vs 1.06 (0.73-1.56) ≥10.1 ≤0 activity, mg/day Ptrend:0.15 processed meat, red meat intake, smoking status, smoking status, vitamin c, vitamin e supplement +Vitamin e per 10 mg/day 1.01 (1.00-1.03) intake Hansen, 2009 DCH, 73/ Cancer registry FFQ Incidence, Alcohol intake, COL40855 Case Cohort, 57 053 colorectal per 10 mg/day 0.96 (0.89-1.03) Denmark Age: 50-64 cancer, gpx1 BMI, fruits and vegetables years pro198leu ct consumption, 72/ Gpx1 pro198leu HRT use, per 10 mg/day 0.99 (0.94-1.04) cc smoking, years 22/ Gpx1 pro198leu per 10 mg/day 1.26 (0.98-1.62) tt Iso, 2007 JACC, 209/ Mortality, colon Municipal FFQ use vs no use 1.76 (0.98-3.17) COL40707 Prospective 105 500 cancer, men resident
years 237 Supplemental vitamin E and colorectal cancer risk. Main characteristics of cohort studies identified in the CUP SLR Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Roswall, 2010 COL40797 Denmark DCH, Prospective Cohort, Age: 50-64 M/W 465 56 332 10.6 years Cancer registry FFQ Incidence, cancer ≥10.1 vs ≤0 mg/day 1.06 (0.73-1.56) Ptrend:0.15 Age, alcohol intake, beta carotene, BMI, educational level, folate intake, hormone use, physical activity, processed meat, red meat intake, smoking status, smoking status, vitamin c, vitamin e supplement per 10 mg/day 1.01 (1.00-1.03) +Vitamin e intake Hansen, 2009 COL40855 Denmark DCH, Case Cohort, Age: 50-64 years 73/ 57 053 Cancer registry FFQ Incidence, colorectal cancer, gpx1 pro198leu ct per 10 mg/day 0.96 (0.89-1.03) Alcohol intake, BMI, fruits and vegetables consumption, HRT use, smoking, 72/ Gpx1 pro198leu cc per 10 mg/day 0.99 (0.94-1.04) 22/ Gpx1 pro198leu tt per 10 mg/day 1.26 (0.98-1.62) Iso, 2007 COL40707 JACC, Prospective 209/ 105 500 Municipal resident FFQ Mortality, colon cancer, men use vs no use 1.76 (0.98-3.17)
CUP_colorectal_SLR_2016_RO.docx