Table 133 Coffee consumption and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Cases/ Author, Year, Missing data name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analyses per 100 ml/day 1.01 (0.99-1.02) Age, sex, 4 234/ Incidence, alcohol 477 071 High vs non/low colorectal cancer 1.06 (0.95-1.18) consumption, 11.6 years consumption BMI, centre per 100 ml/day 1.00 (0.99-1.01) location, dairy Incidence, Dik, 2014 2 691 products High vs non/low cancer 0.99 (0.86-1.13) COL40993 consumption, consumption EPIC, Denmark, diabetes, Prospective per 100 ml/day 1.01 (0.99–1.03) France, Cancer registry/ Incidence, educational Unit converted Cohort, Germany, 1 242 population Questionnaire proximal colon level, energy to cups/day High vs non/low Age: 25-70 1.06 (0.87–1.30) Greece, Italy register cancer from fat, energy consumption years, ,Netherlands, from non-fat M/W per 100 ml/day 0.99 (0.97–1.01) Norway, Spain, sources, fibre, Incidence, distal 1 202 Sweden, UK HRT use, High vs non/low colon cancer 0.94 (0.76–1.15) menopausal consumption status, physical per 100 ml/day 1.02 (1.00-1.03) activity, red and Incidence, rectal 1 563/ processed meat, High vs non/low cancer 1.2 (1.00-1.44) smoking consumption JACC, 557/ Yamada, 2014 Cancer registry Incidence, Prospective 58 1.57 (0.97-2.55) COL41013 and hospital colorectal Cohort, 738 669 Ptrend:0.03 Japan records questionnaire cancer, men M/W
Table 133 Coffee consumption and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analyses Dik, 2014 COL40993 Denmark, France, Germany, Greece, Italy ,Netherlands, Norway, Spain, Sweden, UK EPIC, Prospective Cohort, Age: 25-70 years, M/W 4 234/ 477 071 11.6 years Cancer registry/ population register Questionnaire Incidence, colorectal cancer per 100 ml/day 1.01 (0.99-1.02) Age, sex, alcohol consumption, BMI, centre location, dairy products consumption, diabetes, educational level, energy from fat, energy from non-fat sources, fibre, HRT use, menopausal status, physical activity, red and processed meat, smoking Unit converted to cups/day High vs non/low consumption 1.06 (0.95-1.18) 2 691 Incidence, cancer per 100 ml/day 1.00 (0.99-1.01) High vs non/low consumption 0.99 (0.86-1.13) 1 242 Incidence, proximal colon cancer per 100 ml/day 1.01 (0.99–1.03) High vs non/low consumption 1.06 (0.87–1.30) 1 202 Incidence, distal colon cancer per 100 ml/day 0.99 (0.97–1.01) High vs non/low consumption 0.94 (0.76–1.15) 1 563/ Incidence, rectal cancer per 100 ml/day 1.02 (1.00-1.03) High vs non/low consumption 1.2 (1.00-1.44) Yamada, 2014 COL41013 Japan JACC, Prospective Cohort, M/W 557/ 58 738 669 Cancer registry and hospital records questionnaire Incidence, colorectal cancer, men 1.57 (0.97-2.55) Ptrend:0.03 analysis
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