Age, alcohol consumption, BMI, calcium intake, diabetes, educational attainment, energy intake, family history of SWHS, Plasma folate colorectal Nested Case Cancer Shrubsole, 2009 level were cancer, Mid-points of Control, 303/ registry/death Incidence, 11.1-304 vs COL40772 analysed using 1.20 (0.80-1.70) intake, history of exposure Age: 40-70 1188 controls colorectal cancer 2.04-7.54 ng/ml China microbiological polyps, HRT categories. years, assay use, Income, W menopausal status, nsaid use, physical activity, red meat intake, smoking status, vegetable intake, vitamin use 163/ Incidence, vs ≥8.6 ≤5.5 324 controls colorectal 0.86 (0.45-1.60) ng/ml 11.5 years cancer, men JPHC, Plasma folate Nested Case 160/ vs Otani, 2008 Cancer ≥10.6 registry ≤6.7 measured by Women 1.00 (0.56-1.90) Control, 297 controls ng/ml COL40673 and Age: 40-69 certificates 119/ Incidence, colon vs years, ≥8.6 ≤5.5 0.82 (0.39-1.70) immunoassay, 237 M/W controls cancer, men ng/ml 106/ vs ≥10.6 ≤6.7 Women 0.97 (0.47-2.00) 195 controls ng/ml
Shrubsole, 2009 COL40772 China SWHS, Nested Case Control, Age: 40-70 years, W 303/ 1188 controls Cancer registry/death Plasma folate level were analysed using microbiological assay Incidence, colorectal cancer 11.1-304 vs 2.04-7.54 ng/ml 1.20 (0.80-1.70) Age, alcohol consumption, BMI, calcium intake, diabetes, educational attainment, energy intake, family history of colorectal cancer, intake, history of polyps, HRT use, Income, menopausal status, nsaid use, physical activity, red meat intake, smoking status, vegetable intake, vitamin use Mid-points of exposure categories. Otani, 2008 COL40673 JPHC, Nested Case Control, Age: 40-69 years, M/W 163/ 324 controls 11.5 years Cancer registry and certificates Plasma folate measured by immunoassay, Incidence, colorectal cancer, men ≥8.6 vs ≤5.5 ng/ml 0.86 (0.45-1.60) 160/ 297 controls Women ≥10.6 vs ≤6.7 ng/ml 1.00 (0.56-1.90) 119/ 237 controls Incidence, colon cancer, men ≥8.6 vs ≤5.5 ng/ml 0.82 (0.39-1.70) 106/ 195 controls Women ≥10.6 vs ≤6.7 ng/ml 0.97 (0.47-2.00)
CUP_colorectal_SLR_2016_RO.docx