Incidence, rectal 159 1.53 (0.77–3.03) cancer ATBC, 106/ Age, BMI, Incidence, colon Nested Case 27002 controls 2.09 (1.34-3.26) calcium, cancer Hartman, 1998 Control, Recall 6.1 years vs 0 Intervention Mid-point ≥1 COL00214 Age: 50-69 Cancer registry questionnaire + cups/day categories Finland years, FFQ Incidence, rectal occupational 79/ 0.87 (0.47-1.60) M, cancer physical activity Male Smokers 146Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis. Cases/ Author, Year, Study name, Study size Case categories RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Age, alcohol, 325/ Incidence, >2 vs <1 0.89 (0.66-1.19) BMI, diabetes, 61 321 advanced colon cups/day Ptrend:0.40 SCHS, dialect group, 9.8 years cancer Prospective educational Peterson, 2010 Cancer registry Advanced and Cohort, level, family COL40820 and pathology localized colon Age: 45-74 history of 229/ Incidence, Singapore register cancer >2 vs <1 0.82 (0.59-1.14) years, colorectal 61 321 localized colon cups/day Ptrend:0.24 M/W cancer, gender, 9.8 years cancer green tea, physical
159 Incidence, rectal cancer 1.53 (0.77–3.03) Hartman, 1998 COL00214 Finland ATBC, Nested Case Control, Age: 50-69 years, M, Male Smokers 106/ 27002 controls 6.1 years Cancer registry Recall questionnaire + FFQ Incidence, colon cancer ≥1 vs 0 cups/day 2.09 (1.34-3.26) Age, BMI, calcium, Intervention occupational physical activity Mid-point categories 79/ Incidence, rectal cancer 0.87 (0.47-1.60) 146Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis. Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment categories assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Peterson, 2010 COL40820 Singapore SCHS, Prospective Cohort, Age: 45-74 years, M/W 325/ 61 321 9.8 years Cancer registry and pathology register Incidence, advanced colon cancer >2 vs <1 cups/day 0.89 (0.66-1.19) Ptrend:0.40 Age, alcohol, BMI, diabetes, dialect group, educational level, family history of colorectal cancer, gender, green tea, physical Advanced and localized colon cancer 229/ 61 321 9.8 years Incidence, localized colon cancer >2 vs <1 cups/day 0.82 (0.59-1.14) Ptrend:0.24
CUP_colorectal_SLR_2016_RO.docx