Human Health Hazard Summary Table Phthalate Acute Irritation & Repeated Dose Toxicity Genetic Carcinogenicity Fertility Developmental Toxicity Sensitisation Toxicity Toxicity Di-C7-9-alkyl Oral: Skin irritation: Rat: No data No data NOAEL = NOAEL = 500 phthalate (Di- Rat: Negative NOAEL = 60 mg/kg bw/d 1000 mg/kg mg/kg bw/d bw/d C7-9 PE) LD50 >15000 LOAEL = 120 mg/kg bw/d, LOAEL = 1000 - mg/kg bw/d Eye irritation: LOAEL = haemoglobin levels and red ↓ mg/kg bw Negative not skeletal blood cell counts and ↑ ↑ established variations (lumbar urinary cell excretion. Dermal: Respiratory ribs) High testicular tubular No data irritation: atrophy; hepatic centrilobular No data degeneration, hepatocyte Inhalation: swelling, fatty vacuolation. No data Skin PP noted sensitisation: Negative increase; decrease; PP: peroxisome proliferation ↑: ↓:
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Di-C7-9-alkyl phthalate (Di- C7-9 PE) Oral: Rat: LD50 >15000 - mg/kg bw Dermal: No data Inhalation: No data Skin irritation: Negative Eye irritation: Negative Respiratory irritation: No data Skin sensitisation: Negative Rat: NOAEL = 60 mg/kg bw/d LOAEL = 120 mg/kg bw/d, ↓ haemoglobin levels and red blood cell counts and ↑ urinary cell excretion. High testicular tubular atrophy; hepatic centrilobular degeneration, hepatocyte swelling, fatty vacuolation. PP noted No data No data NOAEL = 1000 mg/kg bw/d LOAEL = not established NOAEL = 500 mg/kg bw/d LOAEL = 1000 mg/kg bw/d ↑ skeletal variations (lumbar ribs) ↑: increase; ↓: decrease; PP: peroxisome proliferation
DiC7-9-PE-hazard-assessment.docx