meat intake, smoking habits Table 333 Waist circumference and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) 1 904/ Age, alcohol, Incidence, 144 701 per 1 z-score 1.18 (1.12-1.23) aspirin use, colorectal cancer 12 diabetes, educational Incidence, 1 904/ 87 vs < 87 cm 1.20 (1.08-1.32) level, ethnicity, ≥ colorectal cancer WHI, Self-report family history of Heo, 2015 Incidence, colon Prospective verified by colorectal 1 516/ per 1 1.19 (1.12-1.26) COL41057 z-scores cancer Cohort, medical record Measured cancer, folate USA reported Age: 50-79 and pathology intake, height, Incidence, colon USA 1 516/ 76 vs < 76 cm 1.27 (1.13-1.43) W report ≥ hormone use, cancer physical Incidence, rectal activity, 257/ per 1 score 1.06 (0.93-1.22) cancer randomisation, red meat intake, Incidence, rectal 257/ per 1 score 1.06 (0.93-1.21) smoking cancer Kabat, 2015 WHI, 1 908/ Self-report Age, alcohol, Weight, height, Incidence, 2.50 (1.73-3.63) COL41034 Prospective 143 901 verified by Q 5 vs Q 1 aspirin use, and and hip colorectal Ptrend:<0.0001 USA Cohort, 12.7 years medical record diabetes,
meat intake, smoking habits Table 333 Waist circumference and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country name, characteristics Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Heo, 2015 COL41057 USA USA WHI, Prospective Cohort, Age: 50-79 W 1 904/ 144 701 12 Self-report verified by medical record and pathology report Measured Incidence, colorectal cancer per 1 z-score 1.18 (1.12-1.23) Age, alcohol, aspirin use, diabetes, educational level, ethnicity, family history of colorectal cancer, folate intake, height, hormone use, physical activity, randomisation, red meat intake, smoking z-scores reported 1 904/ Incidence, colorectal cancer ≥ 87 vs < 87 cm 1.20 (1.08-1.32) 1 516/ Incidence, colon cancer per 1 1.19 (1.12-1.26) 1 516/ Incidence, colon cancer ≥ 76 vs < 76 cm 1.27 (1.13-1.43) 257/ Incidence, rectal cancer per 1 score 1.06 (0.93-1.22) 257/ Incidence, rectal cancer per 1 score 1.06 (0.93-1.21) Kabat, 2015 COL41034 USA WHI, Prospective Cohort, 1 908/ 143 901 12.7 years Self-report verified by medical record Weight, height, and and hip Incidence, colorectal Q 5 vs Q 1 2.50 (1.73-3.63) Ptrend:<0.0001 Age, alcohol, aspirin use, diabetes,
CUP_colorectal_SLR_2016_RO.docx