54/ Incidence, rectal vs physical ≥10.6 ≤6.7 1.50 (0.38-5.50) 102 controls cancer, women ng/ml activity, study area, vitamin use 44/ vs ≥8.6 ≤5.5 Men 0.63 (0.11-3.60) 87 controls ng/ml 275/ Incidence, 12.9 vs 5.7 ATBC, Age, BMI, date 275 controls 1.07 (0.60-1.91) Exposure unit in colorectal cancer nmol/l Nested Case 14.2 years of blood Weinstein, 2008 nmol/l, divided Control, Serum folate collection, Iron COL40687 Cancer registry by conversion 151/ Incidence, colon 12.9 vs 5.7 Age: 50-69 by radioassay intake, physical 1.41 (0.62-3.23) Finland factor 2.266 to 151 controls cancer nmol/l years, activity, vitamin convert to ng/ml M d 126/ Incidence, rectal 12.9 vs 5.7 0.67 (0.27-1.71) 126 controls cancer nmol/l Busselton (Western Australia) Health Survey, Serum folate Age, sex, Rossi, 2006 41/ 1969, By Incidence, alcohol intake, COL40759 1 988 Death register per 2 mcg/litre 0.83 (0.62-1.10) Prospective microbiological colorectal cancer BMI, smoking Australia 29 years Cohort, assay system habits Age: 40-90 years, M/W Age, sex, 221/ Incidence, vs ≥15 ≤4.9 NSHDC, alcohol intake, 432 controls 1.01 (0.47-2.19) colorectal cancer nmol/l Van Guelpen B, Nested Case BMI, date of 4.2 years Plasma folate Mid-points of 2006 Control, enrolment, Cancer registry by Quantaphase exposure COL40681 Age: 25-74 fasting II radioassay categories. 82/ Incidence, rectal Sweden years, condition, Q 5 vs Q 1 0.50 (0.15-1.55) 157 controls cancer M/W physical activity,
physical activity, study area, vitamin use 54/ 102 controls Incidence, rectal cancer, women ≥10.6 vs ≤6.7 ng/ml 1.50 (0.38-5.50) 44/ 87 controls Men ≥8.6 vs ≤5.5 ng/ml 0.63 (0.11-3.60) Weinstein, 2008 COL40687 Finland ATBC, Nested Case Control, Age: 50-69 years, M 275/ 275 controls 14.2 years Cancer registry Serum folate by radioassay Incidence, colorectal cancer 12.9 vs 5.7 nmol/l 1.07 (0.60-1.91) Age, BMI, date of blood collection, Iron intake, physical activity, vitamin d Exposure unit in nmol/l, divided by conversion factor 2.266 to convert to ng/ml 151/ 151 controls Incidence, colon cancer 12.9 vs 5.7 nmol/l 1.41 (0.62-3.23) 126/ 126 controls Incidence, rectal cancer 12.9 vs 5.7 nmol/l 0.67 (0.27-1.71) Rossi, 2006 COL40759 Australia Busselton (Western Australia) Health Survey, 1969, Prospective Cohort, Age: 40-90 years, M/W 41/ 1 988 29 years Death register Serum folate By microbiological assay system Incidence, colorectal cancer per 2 mcg/litre 0.83 (0.62-1.10) Age, sex, alcohol intake, BMI, smoking habits Van Guelpen B, 2006 COL40681 Sweden NSHDC, Nested Case Control, Age: 25-74 years, M/W 221/ 432 controls 4.2 years Cancer registry Plasma folate by Quantaphase II radioassay Incidence, colorectal cancer ≥15 vs ≤4.9 nmol/l 1.01 (0.47-2.19) Age, sex, alcohol intake, BMI, date of enrolment, fasting condition, physical activity, Mid-points of exposure categories. 82/ 157 controls Incidence, rectal cancer Q 5 vs Q 1 0.50 (0.15-1.55)
CUP_colorectal_SLR_2016_RO.docx