higher doses (often>200% of US RDA) of several B vitamins and often large doses of vitamin C or selected supplements minerals, such as (nyes=30) selenium or zinc. 0.89 (0.57-1.37) Supplement < 10 mixtures : components, such as B complex or antioxidant mixtures, were not considered multivitamins McCarl, 2006 IWHS, 936/ SEER registry FFQ Incidence, COL40633 Prospective 35 197 colorectal cancer USA Cohort, 15 years Multivitamins yes vs no 0.82 (0.71-0.94) Age Age: 55-69 (no details) years, W Zhang, 2006 WHS, 220/ Self-report, FFQ Incidence, Age, alcohol abuse, COL40742 Prospective 37 916 report, national colorectal cancer aspirin use, BMI, USA Cohort, 10.1 death Index, Multivitamins family history of Age: 45- years, medical records (no details) colorectal cancer In W, reviewed by current use vs first degree relatives, 1.07 (0.72-1.61) Health physicians never use folate intake, history of professionals polyps, menopausal status, physical activity, postmenopausal
higher doses (often>200% of US RDA) of several B vitamins and often large doses of vitamin C or selected minerals, such as selenium or zinc. Supplement mixtures : < 10 components, such as B complex or antioxidant mixtures, were not considered multivitamins supplements (nyes=30) 0.89 (0.57-1.37) McCarl, 2006 COL40633 USA IWHS, Prospective Cohort, Age: 55-69 years, W 936/ 35 197 15 years SEER registry FFQ Multivitamins (no details) Incidence, colorectal cancer yes vs no 0.82 (0.71-0.94) Age Zhang, 2006 COL40742 USA WHS, Prospective Cohort, Age: 45- years, W, Health professionals 220/ 37 916 10.1 Self-report, report, national death Index, medical records reviewed by physicians FFQ Multivitamins (no details) Incidence, colorectal cancer current use vs never use 1.07 (0.72-1.61) Age, alcohol abuse, aspirin use, BMI, family history of colorectal cancer In first degree relatives, folate intake, history of polyps, menopausal status, physical activity, postmenopausal
CUP_colorectal_SLR_2016_RO.docx