years, reports vs cancer, ≥225.6 54/ Hmlh1- cases 0.92 (0.43-2.00) M/W mcg/day energy Age, alcohol 368/ Incidence, colon consumption, 88 758 cancer, no vs ≥400 ≤200 0.98 (0.72-1.33) aspirin use, 1 375 165 family history of mcg/day beef, pork, or Superseded by crc NHS, lamb, BMI, the Pooling Prospective 2002 Self-reported energy-adjusted Project Kim, Cohort, COL00415 and National FFQ levels of 2010 for colon Age: 30-55 USA Death Index methionine, cancer dose W, No family physical response 295/ vs year 1.12 (0.83-1.50) nurses ≥5 ≤0 history of crc activity, screening endoscopy, smoking habits per 50 mcg/day 0.88 (0.78-0.99) 400/ Incidence, 120 852 vs cancer, men ≥266 ≤168 0.73 (0.46-1.17) 7.3 years mcg/day vs ≥243 ≤150 0.68 (0.39-1.20) mcg/day 360/ Colon cancer, NLCS, women per 50 mcg/day 0.96 (0.81-1.13) Konings, 2002 Case Cohort, COL01271 Age: 55-69 Cancer registries vs FFQ ≥266 ≤168 0.66 (0.35-1.21) Netherlands years, Incidence, rectal mcg/day 259/ M/W cancer, men per 50 mcg/day 0.87 (0.74-1.02) Distal colon vs ≥266 ≤168 194/ 0.74 (0.40-1.35) cancer, men mcg/day Proximal colon vs ≥266 ≤168 186/ 0.75 (0.39-1.44) cancer, men mcg/day
years, M/W reports cancer, energy 54/ Hmlh1- cases ≥225.6 vs mcg/day 0.92 (0.43-2.00) 2002 COL00415 USA NHS, Prospective Cohort, Age: 30-55 W, nurses 368/ 88 758 1 375 165 Self-reported and National Death Index FFQ Incidence, colon cancer, no family history of crc ≥400 vs ≤200 mcg/day 0.98 (0.72-1.33) Age, alcohol consumption, aspirin use, beef, pork, or lamb, BMI, energy-adjusted levels of methionine, physical activity, screening endoscopy, smoking habits Superseded by the Pooling Project Kim, 2010 for colon cancer dose response 295/ No family history of crc ≥5 vs ≤0 year 1.12 (0.83-1.50) Konings, 2002 COL01271 Netherlands NLCS, Case Cohort, Age: 55-69 years, M/W 400/ 120 852 7.3 years Cancer registries FFQ Incidence, cancer, men per 50 mcg/day 0.88 (0.78-0.99) ≥266 vs ≤168 mcg/day 0.73 (0.46-1.17) 360/ Colon cancer, women ≥243 vs ≤150 mcg/day 0.68 (0.39-1.20) per 50 mcg/day 0.96 (0.81-1.13) 259/ Incidence, rectal cancer, men ≥266 vs ≤168 mcg/day 0.66 (0.35-1.21) per 50 mcg/day 0.87 (0.74-1.02) 194/ Distal colon cancer, men ≥266 vs ≤168 mcg/day 0.74 (0.40-1.35) 186/ Proximal colon cancer, men ≥266 vs ≤168 mcg/day 0.75 (0.39-1.44)
CUP_colorectal_SLR_2016_RO.docx