Table 236 Supplemental vitamin E and colorectal cancer risk. Main characteristics of RCT studies identified in the CUP SLR Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country Virtamo, 2013 ATBC, 676/ Finnish cancer Incidence, alpha-tocopherol COL41003 Randomised 25 563 registry and colorectal cancer vs no 1.02 (0.87-1.18) Finland Control 18 years death certificates Age: 50-69 347/ years, 1.03 (0.83-1.27) M, vs placebo Male Smokers Klein, 2011 SELECT, 160/ Self-report Questionnaire Incidence COL40894 Randomised 34 887 verified by vitamin e North America Control 54 646 medical record 1.09 (0.72-1.64) supplement vs Age: years, and pathology Ptrend:0.60 placebo M, report healthy men Lippman, 2009 SELECT, 137/ FFQ Incidence, vit e and COL40767 Randomised 35 533 report/hospital colorectal cancer selenium vs 1.28 (0.82-2.00) USA Control 5.46 years placebo Age: 50- years, reports 126/ vitamin e from M 1.09 (0.69-1.73) suppl vs placebo 23/ Mortality, vitamin e from 1.30 (0.44-3.83) colorectal cancer vs placebo Gaziano, 2009 PHS II, 162/ Self report FFQ Incidence, Age, other vit e assignment COL40770 Randomised 13 983 verified by colorectal cancer 0.88 (0.64-1.19) design Issue, vs placebo USA Control 8 medical record randomized Age: 50- years, treatment 53/ Mortality, vit e assignment M, 0.68 (0.39-1.18) assignment, colorectal cancer vs placebo
Table 236 Supplemental vitamin E and colorectal cancer risk. Main characteristics of RCT studies identified in the CUP SLR Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Virtamo, 2013 COL41003 Finland ATBC, Randomised Control Age: 50-69 years, M, Male Smokers 676/ 25 563 18 years Finnish cancer registry and death certificates Incidence, colorectal cancer alpha-tocopherol vs no 1.02 (0.87-1.18) 347/ vs placebo 1.03 (0.83-1.27) Klein, 2011 COL40894 North America SELECT, Randomised Control Age: years, M, healthy men 160/ 34 887 54 646 Self-report verified by medical record and pathology report Questionnaire Incidence vitamin e supplement vs placebo 1.09 (0.72-1.64) Ptrend:0.60 Lippman, 2009 COL40767 USA SELECT, Randomised Control Age: 50- years, M 137/ 35 533 5.46 years reports FFQ Incidence, colorectal cancer vit e and selenium vs placebo 1.28 (0.82-2.00) 126/ vitamin e from suppl vs placebo 1.09 (0.69-1.73) 23/ Mortality, colorectal cancer vitamin e from vs placebo 1.30 (0.44-3.83) Gaziano, 2009 COL40770 USA PHS II, Randomised Control Age: 50- years, M, 162/ 13 983 8 Self report verified by medical record FFQ Incidence, colorectal cancer vit e assignment vs placebo 0.88 (0.64-1.19) Age, other design Issue, randomized treatment assignment, 53/ Mortality, colorectal cancer vit e assignment vs placebo 0.68 (0.39-1.18) report/hospital
CUP_colorectal_SLR_2016_RO.docx