COL40670 Prospective 1 222 630 National health Incidence, kg/m2 Age, alcohol UK Cohort, 5 years records colorectal cancer consumption, categories per 10 unit 1.00 (0.92-1.08) Age: 50-64 geographical years, area, physical Person-years of W 1 884/ Never smoked per 10 unit 1.04 (0.92-1.18) activity, follow up reproductive Postmenopausal factors, smoking 1 743/ users of per 10 unit 0.99 (0.88-1.12) status, HRT status per 10 unit 0.99 (0.87-1.13) Mortality, 1 548/ 30 vs < 22.5 colorectal cancer ≥ 1.03 (0.92-1.16) kg/m2 Incidence, colorectal cancer, 136/ per 10 unit 1.61 (1.05-2.48) premenopausal never users of HRT > 30 vs < 18.5 ATBC, 1.66 (1.27-2.18) kg/m2 Bowers, 2006 Prospective 410/ Incidence, Measured by COL40699 Cohort, 28 983 Cancer registry 29.21-54.36 vs colorectal cancer trained staff 1.70 (1.01-2.85) Finland Age: 14.1 58 years 12.97-23.11 Ptrend:0.01 M, kg/m2
COL40670 UK Prospective Cohort, Age: 50-64 years, W 1 222 630 5 years National health records Incidence, colorectal cancer kg/m2 Age, alcohol consumption, geographical area, physical activity, reproductive factors, smoking status, status categories Person-years of follow up per 10 unit 1.00 (0.92-1.08) 1 884/ Never smoked per 10 unit 1.04 (0.92-1.18) 1 743/ Postmenopausal users of HRT per 10 unit 0.99 (0.88-1.12) 1 548/ Mortality, colorectal cancer per 10 unit 0.99 (0.87-1.13) ≥ 30 vs < 22.5 kg/m2 1.03 (0.92-1.16) 136/ Incidence, colorectal cancer, premenopausal never users of HRT per 10 unit 1.61 (1.05-2.48) Bowers, 2006 COL40699 Finland ATBC, Prospective Cohort, Age: 58 M, 410/ 28 983 14.1 years Cancer registry Measured by trained staff Incidence, colorectal cancer > 30 vs < 18.5 kg/m2 1.66 (1.27-2.18) 29.21-54.36 vs 12.97-23.11 kg/m2 1.70 (1.01-2.85) Ptrend:0.01
CUP_colorectal_SLR_2016_RO.docx