Table 250 Dietary folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Cases/ Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Incidence, colorectal EPIC-Norfolk, per 1 sd 0.92 (0.52-1.65) cancer, gc:at Prospective Gay, 2012 185/ Case-only study, mutations Cohort, 7-day dietary Age, sex, COL40920 25 636 Cancer registry only interaction Age: 45-79 recalls smoking Apc promoter UK 11 years results years, methylation per 1 sd units 0.55 (0.35-0.85) M/W ≥20% Apc mutations per 1 sd units 0.91 (0.65-1.27) Lee, 2011 NHS+HPFS 2299/ Self-reported FFQ Incidence, Age, calendar USA 87891men and and medical colorectal cancer year, pack-years 47290 women records of smoking before age 30 y, physical activity, aspirin dose, height, BMI, family history of colorectal Superseded by years vs ≥500 1.02 (0.84, 1.24) cancer in Pooling Project <250 mcg/d parents and Kim, 2010 siblings, menopausal status and hormone therapy use, history of endoscopy, and intakes of red meat, alcohol,
Table 250 Dietary folate and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Gay, 2012 COL40920 UK EPIC-Norfolk, Prospective Cohort, Age: 45-79 years, M/W 185/ 25 636 11 years Cancer registry 7-day dietary recalls Incidence, colorectal cancer, gc:at mutations per 1 sd 0.92 (0.52-1.65) Age, sex, smoking Case-only study, only interaction results Apc promoter methylation ≥20% per 1 sd units 0.55 (0.35-0.85) Apc mutations per 1 sd units 0.91 (0.65-1.27) Lee, 2011 USA NHS+HPFS 2299/ 87891men and 47290 women Self-reported and medical records FFQ Incidence, colorectal cancer ≥500 years vs <250 mcg/d 1.02 (0.84, 1.24) Age, calendar year, pack-years of smoking before age 30 y, physical activity, aspirin dose, height, BMI, family history of colorectal cancer in parents and siblings, menopausal status and hormone therapy use, history of endoscopy, and intakes of red meat, alcohol, Superseded by Pooling Project Kim, 2010 analysis
CUP_colorectal_SLR_2016_RO.docx