eosinophilic basophilic electron microscopy Disease Inclusion name Photo Location (in cell) Cells affected Contents Parkinson disease Lewy bodies cytoplasm neurons and neurofilament, tubulin, ubiquitin α-synuclein Pick disease Pick bodies cytoplasm neurons (frontotemporal dementia) Neurofibrillary Alzheimer disease cytoplasm neurons tau protein tangles Normal aging, neurodegenerative disorders (Alzheimer's disease, Pick Hirano bodies cytoplasm neurons and actin-related proteins; no ubiquitin! actin disease, Creutzfeldt-Jakob disease) Simchowicz Normal aging, bodies neurodegenerative disorders cytoplasm unknown composition (granulovacuolar (Alzheimer's disease) degeneration) ALS Bunina bodies cytoplasm neurons unknown composition Familial myoclonic Lafora bodies cytoplasm neurons epilepsy H&E: Senile degenerative process Corpora amylacea PAS: Age-associated degen. Marinesco bodies cytoplasm neurons ubiquitin? changes in substantia nigra Psammoma Meningioma bodies Schwannoma Verocay body extracellular
eosinophilic basophilic electron microscopy Disease Inclusion name Photo Location (in cell) Cells affected Contents Parkinson disease Lewy bodies cytoplasm neurons neurofilament, tubulin, α-synuclein and ubiquitin Pick disease (frontotemporal dementia) Pick bodies cytoplasm neurons Alzheimer disease Neurofibrillary tangles cytoplasm neurons tau protein Normal aging, neurodegenerative disorders (Alzheimer's disease, Pick disease, Creutzfeldt-Jakob disease) Hirano bodies cytoplasm neurons actin and actin-related proteins; no ubiquitin! Normal aging, neurodegenerative disorders (Alzheimer's disease) Simchowicz bodies (granulovacuolar degeneration) cytoplasm unknown composition ALS Bunina bodies cytoplasm neurons unknown composition Familial myoclonic epilepsy Lafora bodies cytoplasm neurons Senile degenerative process Corpora amylacea H&E: PAS: Age-associated degen. changes in substantia nigra Marinesco bodies cytoplasm neurons ubiquitin? Meningioma Psammoma bodies Schwannoma Verocay body extracellular
D34.%20Brain%20Biopsy.docx