Table Lactose intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, size Case Exposure RR (95%CI) WCRF Code, Outcome Comparison Adjustment factors characteristics Follow-up ascertainment assessment Ptrend Country (years) Jarvinen, 2001 Finnish Mobile 72/ Population Questionnaire Incidence, 0.91 COL00314 Clinic Health 9 959 colorectal cancer q 4 vs q 1 Finland Examination 19.6 years Ptrend:0.38 Survey, Age, sex, area of residence, BMI, 38/ Incidence, colon 0.31 Prospective energy intake, occupational group, cancer q 4 vs q 1 Cohort, smoking habits Ptrend:0.03 Age: 39 years, M/W 34/ Incidence, rectal 2.36 cancer q 4 vs q 1 Ptrend:0.40 Kearney, 1996 HPFS, Responding to Incidence, colon Age, alcohol consumption, aspirin COL00156 Prospective 47 935 mail survey cancer, colon 0.84 use, BMI, dietary fiber, family USA Cohort, 6 years FFQ cancer history of colon cancer, past history Age: 40-75 q 5 vs q 1 Ptrend:0.74 of smoking, physical activity, years, Result previous polyps, red meat intake, M, Number:50410 saturated fat, screening, total Health calories professionals
Table Lactose intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Jarvinen, 2001 COL00314 Finland Finnish Mobile Clinic Health Examination Survey, Prospective Cohort, Age: 39 years, M/W 72/ 9 959 19.6 years Population Questionnaire Incidence, colorectal cancer q 4 vs q 1 0.91 Ptrend:0.38 Age, sex, area of residence, BMI, energy intake, occupational group, smoking habits 38/ Incidence, colon cancer q 4 vs q 1 0.31 Ptrend:0.03 34/ Incidence, rectal cancer q 4 vs q 1 2.36 Ptrend:0.40 Kearney, 1996 COL00156 USA HPFS, Prospective Cohort, Age: 40-75 years, M, Health professionals 47 935 6 years Responding to mail survey FFQ Incidence, colon cancer, colon cancer q 5 vs q 1 0.84 Ptrend:0.74 Result Number:50410 Age, alcohol consumption, aspirin use, BMI, dietary fiber, family history of colon cancer, past history of smoking, physical activity, previous polyps, red meat intake, saturated fat, screening, total calories
CUP_colorectal_SLR_2016_RO.docx