Species, Study Duration, LOAEL Effects at References Route (mg/kg bw/d) (mg/kg (mg/kg bw/d) bw/d) Rat, F344, 0, 100, 1000, 6000, 12000, 11 105 Short et al., 1987* liver: from 1000 ppm ↑p.enz.act. 5 males/group ppm (0, 11, 105, 667, 21 days, diet 1223, 2100) Rat, Wistar 0, 2% (4 w) or NE NE Miyazawa et al., liver: wt during treatment period, ↑ ↓ 3 males/group 2 w, 2% +2 w control diet 1980* during withdrawal period; p.enz.act. ↑ 2-4 weeks, diet during treatment, during withdrawal ↓ Rat, F344 0, 0.2, 0.67, 2.0% (M: 0, 150, NE 150 Nuodex, 1981c* liver: and relw from 0.2%, ↑absw 5 rats/sex/group 504, 1563); (F: 0, 147, 490, total lipids ↑p.enz.act., ↓ 28 days, diet 1416) Rat, F344 0, 1000 NE 1000 Tenneco, 1981* liver: and relw ↑absw 5 males/group 28 days, gavage Rat, F344 0, 0.67% (0, 350) NE 350 Hodgson, 1987* liver: peroxisomes, and ↑relw, ↑nb 5 at 0.67% ↑p.enz.act. 28 days, diet Rat, F344 0 700 NE 700 Hodgson, 1987* liver: peroxisomes, and ↑relw, ↑nb 5 at 700 mg/kg bw/d ↑p.enz.act. 21 days, gavage Rat, F344 0, 0.02, 0.05, 0.1, 0.5, 1.0, NE 24 BIBRA, 1990* liver: from 0.02% ↑relw 5 males/group 2.5% (0, 24, 52, 115, 559, 10 group 1093, 2496) 28 days, diet
Species, Study Duration, Route (mg/kg bw/d) (mg/kg bw/d) LOAEL (mg/kg bw/d) Effects at References Rat, F344, 0, 100, 1000, 6000, 12000, 11 105 liver: ↑p.enz.act. from 1000 ppm Short et al., 1987* 5 males/group ppm (0, 11, 105, 667, 21 days, diet 1223, 2100) Rat, Wistar 0, 2% (4 w) or NE NE liver: ↑ wt during treatment period, ↓ Miyazawa et al., 3 males/group 2-4 weeks, diet 2 w, 2% +2 w control diet during withdrawal period; ↑ p.enz.act. during treatment, ↓ during withdrawal 1980* Rat, F344 0, 0.2, 0.67, 2.0% (M: 0, 150, NE 150 liver: ↑absw and relw from 0.2%, Nuodex, 1981c* 5 rats/sex/group 28 days, diet 504, 1563); (F: 0, 147, 490, 1416) ↑p.enz.act., ↓ total lipids Rat, F344 0, 1000 NE 1000 liver: ↑absw and relw Tenneco, 1981* 5 males/group 28 days, gavage Rat, F344 0, 0.67% (0, 350) NE 350 liver: ↑relw, ↑nb peroxisomes, and Hodgson, 1987* 5 28 days, diet ↑p.enz.act. at 0.67% Rat, F344 0 700 NE 700 liver: ↑relw, ↑nb peroxisomes, and Hodgson, 1987* 5 21 days, gavage ↑p.enz.act. at 700 mg/kg bw/d Rat, F344 0, 0.02, 0.05, 0.1, 0.5, 1.0, NE 24 liver: ↑relw from 0.02% BIBRA, 1990* 5 males/group 2.5% (0, 24, 52, 115, 559, 10 group 1093, 2496) 28 days, diet
DEHP-hazard-assessment.docx