233 Dietary vitamin E and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) McCarl, 2006 IWHS, 954/ SEER registry FFQ Incidence, COL40633 Prospective 35 197 colorectal cancer Included in the USA Cohort, 15 years vs ≥37.5 ≤5.9 0.70 (0.57-0.87) Age Pooling Project. Age: 55-69 mg/day Park, 2010 years, W Malila, 2002 ATBC, 184/ Hospital records Dietary history Incidence, Age, alcohol COL00336 Prospective 26 951 questionnaire colorectal consumption, Finland Cohort, 8 years cancer, BMI, energy Age: 50-69 intake, physical Included in the 17.7 vs 7.5 years, 1.26 (0.83-1.89) activity, serum Pooling Project. mg/day M, cholesterol, Park, 2010 Male Smokers smoking habits, supplementation Wu, 2002 NHS, 336/ Incidence, colon Self-reported, Age, alcohol COL00905 Prospective 87 998 cancer, nhs hospital records consumption, FFQ USA Cohort, 16 years (women) and no and National aspirin use, Age: 30-55 supplemental vit Death Index BMI, family years, e history of W, colorectal nurses cancer, Included in the Q 5 vs Q 1 0.78 (0.55-1.11) menopausal Pooling Project. status, Park, 2010 of smoking, physical activity, postmenopausal hormone use,
233 Dietary vitamin E and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion McCarl, 2006 COL40633 USA IWHS, Prospective Cohort, Age: 55-69 years, W 954/ 35 197 15 years SEER registry FFQ Incidence, colorectal cancer ≥37.5 vs ≤5.9 mg/day 0.70 (0.57-0.87) Age Included in the Pooling Project. Park, 2010 Malila, 2002 COL00336 Finland ATBC, Prospective Cohort, Age: 50-69 years, M, Male Smokers 184/ 26 951 8 years Hospital records Dietary history questionnaire Incidence, colorectal cancer, 17.7 vs 7.5 mg/day 1.26 (0.83-1.89) Age, alcohol consumption, BMI, energy intake, physical activity, serum cholesterol, smoking habits, supplementation Included in the Pooling Project. Park, 2010 Wu, 2002 COL00905 USA NHS, Prospective Cohort, Age: 30-55 years, W, nurses 336/ 87 998 16 years Self-reported, hospital records and National Death Index FFQ Incidence, colon cancer, nhs (women) and no supplemental vit e Q 5 vs Q 1 0.78 (0.55-1.11) Age, alcohol consumption, aspirin use, BMI, family history of colorectal cancer, menopausal status, of smoking, physical activity, postmenopausal hormone use, Included in the Pooling Project. Park, 2010 analysis
CUP_colorectal_SLR_2016_RO.docx