Table 100 Fish and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, Missing data Study name, size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analysis (years) Age, alcohol, BMI, calendar year, calories 1 469/ questionnaire, Incidence, vs ≥40 ≤15 intake, 76 386 national death FFQ 1.02 (0.86-1.20) colorectal cancer g/day endoscopy, 26 years Index, pathology energy-adjusted reports and calcium, medical records folate, 713/ Incidence, NHS, energy-adjusted vs ≥40 ≤15 76 386 proximal colon 0.89 (0.70-1.14) Prospective vitamin d, g/day Song, 2014 26 years cancer Cohort, family history, COL41015 Age: 30-55 fibre, HRT use, Incidence, distal vs ≥40 ≤15 USA 416/ 1.36 (1.00-1.85) years, multivitamin colon cancer g/day W supplement questionnaire, intake, NSAID national death FFQ use, pack years Index, pathology of smoking, reports and 310/ Incidence, rectal vs ≥40 ≤15 physical medical records 76 386 0.98 (0.69-1.40) cancer g/day activity, 26 years postmenopausal status, processed meat, red meat Song, 2014 Health 342/ Self-report, Incidence, distal vs ≥46 ≤16 FFQ 1.12 (0.77-1.64) COL41016 Professionals 47 143 medical records, cancer g/day
Table 100 Fish and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analysis Song, 2014 COL41015 USA NHS, Prospective Cohort, Age: 30-55 years, W 1 469/ 76 386 26 years questionnaire, national death Index, pathology reports and medical records FFQ Incidence, colorectal cancer ≥40 vs ≤15 g/day 1.02 (0.86-1.20) Age, alcohol, BMI, calendar year, calories intake, endoscopy, energy-adjusted calcium, folate, energy-adjusted vitamin d, family history, fibre, HRT use, multivitamin supplement intake, NSAID use, pack years of smoking, physical activity, postmenopausal status, processed meat, red meat 713/ 76 386 26 years questionnaire, national death Index, pathology reports and medical records FFQ Incidence, proximal colon cancer ≥40 vs ≤15 g/day 0.89 (0.70-1.14) 416/ Incidence, distal colon cancer ≥40 vs ≤15 g/day 1.36 (1.00-1.85) 310/ 76 386 26 years Incidence, rectal cancer ≥40 vs ≤15 g/day 0.98 (0.69-1.40) Song, 2014 COL41016 Health Professionals 342/ 47 143 Self-report, medical records, FFQ Incidence, distal cancer ≥46 vs ≤16 g/day 1.12 (0.77-1.64)
CUP_colorectal_SLR_2016_RO.docx