Human Health Hazard Summary Table Phthalate Genetic Toxicity Carcinogenicity Fertility Acute Irritation & Repeated Dose Developmental Toxicity Sensitisation Toxicity Toxicity In No data Mice: Mice: Di-n-hexyl Oral Skin irritation: Rat: phthalate Rat: minimal effect NOAEL = not Negative in NOAEL = not NOAEL = not (DnHP) LD50 = established. bacterial mutation established. established 29600 Eye irritation: LOAEL = 1824 assays LOAEL = 380 mg/kg LOAEL = 380 mg/kg mg/kg bw no data mg/kg bw/d, bw/d, dose-related bw/day; pup ↓ ↑ hepatocellular In vivo: number of mortality Dermal Skin necrosis, fat No data litters/pair, live Rabbit: sensitisation: accumulation, loss of pups/litter and no data LD50 > 20 glycogen; liver proportion of pups ↑ mL/kg bw enzymes born alive increase; decrease ↑: ↓:
Human Health Hazard Summary Table Phthalate Acute Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Fertility Developmental Toxicity Di-n-hexyl phthalate (DnHP) Oral Rat: LD50 = 29600 mg/kg bw Dermal Rabbit: LD50 > 20 mL/kg bw Skin irritation: minimal effect Eye irritation: no data Skin sensitisation: no data Rat: NOAEL = not established. LOAEL = 1824 mg/kg bw/d, hepatocellular necrosis, fat accumulation, loss of glycogen; ↑ liver enzymes In Negative in bacterial mutation assays In vivo: No data No data Mice: NOAEL = not established. LOAEL = 380 mg/kg bw/d, dose-related ↓ number of litters/pair, live pups/litter and proportion of pups born alive Mice: NOAEL = not established LOAEL = 380 mg/kg bw/day; ↑ pup mortality ↑: increase; ↓: decrease
DnHP-hazard-assessment.docx