Table 68 Processed meat and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response analysis Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Age, alcohol, vs 0-16 ≥42 1.02 (0.78-1.34) Incidence, colon beef g/day cancer consumption, per 25 g/day 1.03 (0.94-1.13) cold cuts, educational vs 0-16 ≥42 0.88 (0.60-1.30) level, energy, g/day DCH, Component of fibre, fish, HRT Egeberg, 2013 Prospective 644/ EPIC. use, lamb intake, COL40953 Cohort, 53 988 Cancer registry FFQ Superseded by liver, NSAID Denmark Age: 50-64 13.4 years Norat, 2005 Incidence, rectal use, poultry, M/W COL01698 cancer processed meat, per 25 g/day 0.93 (0.81-1.07) red meat, sausages, smoking, sport, veal meat, waist circumference Incidence, EPIC-Norfolk, colorectal per 1 sd units 1.68 (1.03-2.75) Prospective cancer, gc:at Gay, 2012 185/ Cohort, 7-day dietary mutations COL40920 25 636 Cancer registry Age: 45-79 recalls UK 11 years Apc promoter years, methylation per 1 sd 1.30 (0.91-1.85) M/W ≥20%
Table 68 Processed meat and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Egeberg, 2013 COL40953 Denmark DCH, Prospective Cohort, Age: 50-64 M/W 644/ 53 988 13.4 years Cancer registry FFQ Incidence, colon cancer ≥42 vs 0-16 g/day 1.02 (0.78-1.34) Age, alcohol, beef consumption, cold cuts, educational level, energy, fibre, fish, HRT use, lamb intake, liver, NSAID use, poultry, processed meat, red meat, sausages, smoking, sport, veal meat, waist circumference Component of EPIC. Superseded by Norat, 2005 COL01698 per 25 g/day 1.03 (0.94-1.13) Incidence, rectal cancer ≥42 vs 0-16 g/day 0.88 (0.60-1.30) per 25 g/day 0.93 (0.81-1.07) Gay, 2012 COL40920 UK EPIC-Norfolk, Prospective Cohort, Age: 45-79 years, M/W 185/ 25 636 11 years Cancer registry 7-day dietary recalls Incidence, colorectal cancer, gc:at mutations per 1 sd units 1.68 (1.03-2.75) Apc promoter methylation ≥20% per 1 sd 1.30 (0.91-1.85) analysis
CUP_colorectal_SLR_2016_RO.docx