Numerical data were compared using a two-sample Wilcoxon rank-sum test, and categorical data were compared using a Pearson Chi-square test with test for trend, as appropriate. The associations between the combination of GDM and obesity and the indicators of abnormal fetal growth were modelled using log-binomial regression to obtain adjusted relative risks. The relative risk of AC in the top decile at 28wkGA associated with subsequent GDM was estimated in the whole study group and stratified by maternal obesity, the treatment used, the diagnostic criteria employed, and confined to women with a normal post-partum OGTT. Non-linearity was assessed using fractional polynomials and interactions were tested using the likelihood ratio test. Missing covariate data were imputed using chained equations. All analyses were adjusted for the year of the 28 wkGA scan to take into account any temporal changes in the incidence, screening, diagnosis or treatment of GDM. Analyses were performed with and without adjustment for maternal age, height, ethnicity, weight gain and BMI, as appropriate. Finally, the relative risk of at birth associated with the indicators of abnormal fetal growth was estimated in the group of women who were obese and/or had GDM diagnosed at wGA. All analyses used ≥28 Stata version 14.0. Results Among 4,512 recruited women, a total of 4,305 attended for their 28 wkGA scan (see Sovio et al,10 for flow diagram). Of these, 7 withdrew, 6 failed to attend their 20 wkGA scan, 188 delivered elsewhere, 14 women had pre-existing diabetes, 17 women had GDM diagnosed prior to 28 wkGA and 7 women had missing data on GDM or BMI. A total of 236 (5.5%) of these women had one or more of the exclusion criteria, leaving a study group of 4,069 among whom 171 (4.2%) had a diagnosis of
Numerical data were compared using a two-sample Wilcoxon rank-sum test, and categorical data were compared using a Pearson Chi-square test with test for trend, as appropriate. The associations between the combination of GDM and obesity and the indicators of abnormal fetal growth were modelled using log-binomial regression to obtain adjusted relative risks. The relative risk of AC in the top decile at 28wkGA associated with subsequent GDM was estimated in the whole study group and stratified by maternal obesity, the treatment used, the diagnostic criteria employed, and confined to women with a normal post-partum OGTT. Non-linearity was assessed using fractional polynomials and interactions were tested using the likelihood ratio test. Missing covariate data were imputed using chained equations. All analyses were adjusted for the year of the 28 wkGA scan to take into account any temporal changes in the incidence, screening, diagnosis or treatment of GDM. Analyses were performed with and without adjustment for maternal age, height, ethnicity, weight gain and BMI, as appropriate. Finally, the relative risk of at birth associated with the indicators of abnormal fetal growth was estimated in the group of women who were obese and/or had GDM diagnosed at ≥28 wGA. All analyses used Stata version 14.0. Results Among 4,512 recruited women, a total of 4,305 attended for their 28 wkGA scan (see Sovio et al,10 for flow diagram). Of these, 7 withdrew, 6 failed to attend their 20 wkGA scan, 188 delivered elsewhere, 14 women had pre-existing diabetes, 17 women had GDM diagnosed prior to 28 wkGA and 7 women had missing data on GDM or BMI. A total of 236 (5.5%) of these women had one or more of the exclusion criteria, leaving a study group of 4,069 among whom 171 (4.2%) had a diagnosis of
DC16_0160_MS_R1_HM_comments_24_Feb_2016.docx