Intermediate Risk 4s <365 d not amp any UH asymptomatic or symptomatic Intermediate Risk 4s <365 d missing missing missing asymptomatic or symptomatic High Risk 4s <365 d amp any any asymptomatic or symptomatic # Ploidy: DNA index (DI) greater than 1 (hyperdiploid) or equal to 1 (diploid); hypodiploid tumors (with DI less than 1) will be treated as a tumor with DI greater than 1. Abbreviations: INPC, International Neuroblastoma Pathology Classification; NA, not applicable; amp amplified; FH, favorable histology; UH, unfavorable histology. Provided by the Children’s Oncology Group, June 2009. Reproduced with permission. Table 4. Risk Grouping Scheme for the International Neuroblastoma Risk Group (INRG) System INRG Age Histologic Category/ Tumor MYCN Unbalanced Ploidy Pretreatment Stage Grade 11q Risk Group aberration L1 GN maturing NA A Very Low GNB intermixed Any, except GN maturing or NA B Very Low GNB intermixed Amp I Intermediate L2 GN maturing NA A Very Low GNB intermixed <18 mo Any, except GN maturing or NA No D Low (<547 d) GNB intermixed Yes J Intermediate mo GNB nodular, differentiating NA No E Low ≥18 (≥547 d) NB, differentiating Yes K Intermediate GNB nodular, poorly NA (Any) K Intermediate differentiated or undifferentiated NB, poorly differentiated or undifferentiated (Any) Amp O High M <18 mo NA Hyperdiploid F Low (<547 d) <12 mo Diploid G Low (<365 d) 12-18 mo Diploid H Low (365-<547 d) <18 mo Amp P High (<547 d) mo Q High ≥18 (≥547 d) MS <18 mo NA No C Very Low (<547 d) Yes N Intermediate Amp R High Abbreviations: GN, ganglioneuroma; GNB, ganglioneuroblastoma; NA, not applicable; Amp, amplified, NB,neuroblastoma.
Intermediate Risk 4s <365 d not amp any UH asymptomatic or symptomatic Intermediate Risk 4s <365 d missing missing missing asymptomatic or symptomatic High Risk 4s <365 d amp any any asymptomatic or symptomatic # Ploidy: DNA index (DI) greater than 1 (hyperdiploid) or equal to 1 (diploid); hypodiploid tumors (with DI less than 1) will be treated as a tumor with DI greater than 1. Abbreviations: INPC, International Neuroblastoma Pathology Classification; NA, not applicable; amp amplified; FH, favorable histology; UH, unfavorable histology. Provided by the Children’s Oncology Group, June 2009. Reproduced with permission. Table 4. Risk Grouping Scheme for the International Neuroblastoma Risk Group (INRG) System INRG Stage Age Histologic Category/ Tumor Grade MYCN Unbalanced 11q aberration Ploidy Pretreatment Risk Group L1 GN maturing GNB intermixed NA A Very Low Any, except GN maturing or GNB intermixed NA B Very Low Amp I Intermediate L2 GN maturing GNB intermixed NA A Very Low <18 mo (<547 d) Any, except GN maturing or GNB intermixed NA No D Low Yes J Intermediate ≥18 mo (≥547 d) GNB nodular, differentiating NB, differentiating NA No E Low Yes K Intermediate GNB nodular, poorly differentiated or undifferentiated NB, poorly differentiated or undifferentiated NA (Any) K Intermediate (Any) Amp O High M <18 mo (<547 d) NA Hyperdiploid F Low <12 mo (<365 d) Diploid G Low 12-18 mo (365-<547 d) Diploid H Low <18 mo (<547 d) Amp P High ≥18 mo (≥547 d) Q High MS <18 mo (<547 d) NA No C Very Low Yes N Intermediate Amp R High Abbreviations: GN, ganglioneuroma; GNB, ganglioneuroblastoma; NA, not applicable; Amp, amplified, NB,neuroblastoma.
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