There was evidence of a nonlinear association between total dairy intake and rectal cancer, pnonlinearity=0.02, with a flattening of the dose-response slope at higher levels of intake. Study quality: Total dairy intake was estimated from food intake assessed by FFQ in all studies, and in one of the studies a combination of FFQ, food records and 24 hour recalls were used (Murphy et al, 2013). Loss to follow-up was low for the studies that reported such data, although some studies did not provide data. Cancers were identified by record linkages to health registries, cancer registries, mortality registries, or death indexes. All studies adjusted for at least age, and most of the studies adjusted for most of the established colorectal cancer risk factors, including: age, physical activity, BMI, and alcohol consumption, smoking, red meat and hormone replacement therapy in women. 103 Total dairy product intake and colorectal cancer risk. Number of studies in the CUP SLR Number 13 studies (18 publications) Studies identified Colorectal cancer: 12 studies Studies included in forest plot of highest compared cancer: 6 with lowest intake Rectal cancer: 6 Colorectal cancer: 10 studies Studies included in dose-response cancer: 6 analysis Rectal cancer: 5 Colorectal cancer: 10 studies Studies included in non-linear dose-response Colon cancer: 6 analysis Rectal cancer: 5 Table 104 Total dairy product intake and colorectal cancer risk. Summary of the linear dose-response meta-analysis in the 2005 SLR, 2010 SLR and 2015 SLR 2005 SLR Colorectal cancer Colon cancer Rectal cancer Increment unit used Per 1 Per 200 g/d Per 1 serving/day Per 1 serving/day serving/day Studies (n) 8 2 5 - (total number) - - - - RR (95%CI) 0.97 (0.93-1.01) 0.95 0.95 (0.86-1.06) - Heterogeneity (I2, 11.5%, p=0.34 0%, p=0.86 49.5%, p=0.95 -
There was evidence of a nonlinear association between total dairy intake and rectal cancer, pnonlinearity=0.02, with a flattening of the dose-response slope at higher levels of intake. Study quality: Total dairy intake was estimated from food intake assessed by FFQ in all studies, and in one of the studies a combination of FFQ, food records and 24 hour recalls were used (Murphy et al, 2013). Loss to follow-up was low for the studies that reported such data, although some studies did not provide data. Cancers were identified by record linkages to health registries, cancer registries, mortality registries, or death indexes. All studies adjusted for at least age, and most of the studies adjusted for most of the established colorectal cancer risk factors, including: age, physical activity, BMI, and alcohol consumption, smoking, red meat and hormone replacement therapy in women. 103 Total dairy product intake and colorectal cancer risk. Number of studies in the CUP SLR Number Studies identified 13 studies (18 publications) Studies included in forest plot of highest compared with lowest intake Colorectal cancer: 12 studies cancer: 6 Rectal cancer: 6 Studies included in dose-response Colorectal cancer: 10 studies cancer: 6 Rectal cancer: 5 Studies included in non-linear dose-response Colorectal cancer: 10 studies Colon cancer: 6 Rectal cancer: 5 Table 104 Total dairy product intake and colorectal cancer risk. Summary of the linear dose-response meta-analysis in the 2005 SLR, 2010 SLR and 2015 SLR 2005 SLR Colorectal cancer Colon cancer Rectal cancer Increment unit used Per 1 serving/day Per 200 g/d Per 1 serving/day Per 1 serving/day Studies (n) 8 2 5 - (total number) - - - - RR (95%CI) 0.97 (0.93-1.01) 0.95 0.95 (0.86-1.06) - Heterogeneity (I2, 11.5%, p=0.34 0%, p=0.86 49.5%, p=0.95 - analysis analysis
CUP_colorectal_SLR_2016_RO.docx