Table 105 Dairy intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Studies Heterogeneity Number of Author, Year number of country, Outcome Comparison RR (95%CI) P trend studies (I2, p value) cases area Meta-analyses Huncharek, 12 - Incidence, High vs. low 0.84 (0.75-0.95) - - 2009 America, mortality Europe Aune et al, 12 CRC 11579 North Incidence High vs. low 0.81 (0.74-0.90) - 42%, p=0.06 2012 10 CRC America, Per 400 g/d 0.83 (0.78-0.88) - 24.8%, p=0.22 5 CC Europe High vs. low 0.72 (0.51-1.02) - 50%, p=0.09 Per 400 g/d 0.84 (0.72-0.97) - 35.4%, p=0.19 4 RC High vs. low 0.96 (0.65-1.41) - 44%, p=0.13 Per 400 g/d 1.00 (0.77-1.28) - 68.9%, p=0.02
Table 105 Dairy intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Meta-analyses Huncharek, 2009 12 - America, Europe Incidence, mortality High vs. low 0.84 (0.75-0.95) - - Aune et al, 2012 12 CRC 10 CRC 5 CC 4 RC 11579 North America, Europe Incidence High vs. low Per 400 g/d High vs. low Per 400 g/d High vs. low Per 400 g/d 0.81 (0.74-0.90) 0.83 (0.78-0.88) 0.72 (0.51-1.02) 0.84 (0.72-0.97) 0.96 (0.65-1.41) 1.00 (0.77-1.28) - - - - - - 42%, p=0.06 24.8%, p=0.22 50%, p=0.09 35.4%, p=0.19 44%, p=0.13 68.9%, p=0.02
CUP_colorectal_SLR_2016_RO.docx