Table 299 Total physical activity and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, size Case Exposure RR (95%CI) WCRF Code, Outcome Comparison Adjustment factors characteristics Follow-up ascertainment assessment Ptrend Country 3 759/ Incidence, 347 237 high vs low 0.94 (0.87-1.00) colorectal cancer Questionnaire 12 years Age, sex, overweight on occupational EPIC, activity, Cancer registry and obesity, study Aleksandrova, Prospective walking, (in a few centre, alcohol 2014 Cohort, cycling, centres, consumption, diet COL41051 Age: 25-70 gardening, combination of quality index, Incidence, rectal sports, Europe years, 1390/ high vs low 1.03 (0.92-1.15) methods) education, smoking cancer work, M/W housework and climbing Incidence, colon 2369/ high vs low 0.88 (0.81-0.96) cancer Age, sex, BMI, Interview on SCHS, diabetes, dialect group, strenuous sports Prospective 969/ dietary pattern score, Odegaard, 2013 Cancer registry vigorous work Cohort, 50 466 Incidence, colon vs <1.5 energy intake, sleep ≥1.5 COL40948 and death 0.61 (0.42-0.88) and moderate Age: 45-74 579 628 cancer hours/week time, alcohol intake, activities (e.g., Singapore registry years, education, family walking, M/W history of colorectal bicycling) cancer, smoking
Table 299 Total physical activity and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Aleksandrova, 2014 COL41051 Europe EPIC, Prospective Cohort, Age: 25-70 years, M/W 3 759/ 347 237 12 years Cancer registry (in a few centres, combination of methods) Questionnaire on occupational activity, walking, cycling, gardening, sports, work, housework and climbing Incidence, colorectal cancer high vs low 0.94 (0.87-1.00) Age, sex, overweight and obesity, study centre, alcohol consumption, diet quality index, education, smoking 1390/ Incidence, rectal cancer high vs low 1.03 (0.92-1.15) 2369/ Incidence, colon cancer high vs low 0.88 (0.81-0.96) Odegaard, 2013 COL40948 Singapore SCHS, Prospective Cohort, Age: 45-74 years, M/W 969/ 50 466 579 628 Cancer registry and death registry Interview on strenuous sports vigorous work and moderate activities (e.g., walking, bicycling) Incidence, colon cancer ≥1.5 vs <1.5 hours/week 0.61 (0.42-0.88) Age, sex, BMI, diabetes, dialect group, dietary pattern score, energy intake, sleep time, alcohol intake, education, family history of colorectal cancer, smoking
CUP_colorectal_SLR_2016_RO.docx