99 Fish and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Number of cohort Studies Author, Year number Outcome Comparison RR (95%CI) P studies country, area (I2, p value) of cases Pooled-analysis White fish 0.92 (0.70–1.21) 0.53 Per 50g/day 0.86 (0.64–1.16) vs <1 g/day ≥30 0.33 Colorectal cancer Fatty fish 0.89 (0.70–1.13) Per 50g/day 0.73 (0.54–0.98) vs <1 g/day ≥30 White fish 0.84 (0.59–1.19) 0.32 7 Per 50g/day 0.80 (0.56–1.14) Guernsey Study, 579 cases vs <1 g/day ≥30 EPIC- Norfolk, 1996 Colon cancer Spencer, 2010 UK EPIC-Oxford, NSHD, fish controls 0.82 (0.61–1.11) 0.21 Oxford Vegetarian, Per 50g/day UKWCS, Whitehall 0.73 (0.51–1.04) vs <1 g/day ≥30 fish 1.12 (0.70–1.81) 0.63 Per 50g/day 1.04 (0.61–1.78) vs <1 g/day ≥30 Rectal cancer fish 0.99 (0.68–1.44) 0.95 Per 50g/day 0.68 (0.39–1.18) vs <1 g/day ≥30 Meta-analysis
99 Fish and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P (I2, p value) Pooled-analysis Spencer, 2010 7 Guernsey Study, EPIC- Norfolk, EPIC-Oxford, NSHD, Oxford Vegetarian, UKWCS, Whitehall 579 cases 1996 controls UK Colorectal cancer White fish Per 50g/day ≥30 vs <1 g/day Fatty fish Per 50g/day ≥30 vs <1 g/day 0.92 (0.70–1.21) 0.86 (0.64–1.16) 0.89 (0.70–1.13) 0.73 (0.54–0.98) 0.53 0.33 Colon cancer White fish Per 50g/day ≥30 vs <1 g/day fish Per 50g/day ≥30 vs <1 g/day 0.84 (0.59–1.19) 0.80 (0.56–1.14) 0.82 (0.61–1.11) 0.73 (0.51–1.04) 0.32 0.21 Rectal cancer fish Per 50g/day ≥30 vs <1 g/day fish Per 50g/day ≥30 vs <1 g/day 1.12 (0.70–1.81) 1.04 (0.61–1.78) 0.99 (0.68–1.44) 0.68 (0.39–1.18) 0.63 0.95 Meta-analysis
CUP_colorectal_SLR_2016_RO.docx