Table 132 Coffee and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2010 SLR. Total Number of Heterogeneity Author, Year number of Outcome Comparison RR (95%CI) P trend cohort studies (I2, p value) cases Pooled analysis > 1400 g/day 1.07 (0.89-1.30) 0.68 5 604 Incidence, colon (8-oz cups) cancer 0.99 (0.97-1.02) 4 439 0.45 0.99 (0.96-1.02) Zhang, 2010 13 proximal 2 295 0.98 cancer Per 250 g/day 0.99 (0.96-1.03) 1 820 distal cancer 0.71 Meta-analysis Incidence, 12 1.02 (0.97–1.07) colorectal cancer For 1 cup/day Non-linear Tian, 2013 NA NA 8 Colon cancer 1.01 (0.94–1.08) increment models 8 Rectal cancer 1.04 (0.93–1.16) Incidence, 0.94 (0.88-1.01) colorectal cancer Highest vs Li, 2013 16 10 443 lowest Incidence, colon 0.93 (0.86-1.01) cancer
Table 132 Coffee and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2010 SLR. Author, Year Number of cohort studies Total number of cases Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Pooled analysis Zhang, 2010 13 5 604 Incidence, colon cancer > 1400 g/day (8-oz cups) 1.07 (0.89-1.30) 0.68 4 439 Per 250 g/day 0.99 (0.97-1.02) 0.45 2 295 proximal cancer 0.99 (0.96-1.02) 0.98 1 820 distal cancer 0.99 (0.96-1.03) 0.71 Meta-analysis Tian, 2013 12 NA Incidence, colorectal cancer For 1 cup/day increment 1.02 (0.97–1.07) Non-linear models NA 8 Colon cancer 1.01 (0.94–1.08) 8 Rectal cancer 1.04 (0.93–1.16) Li, 2013 16 10 443 Incidence, colorectal cancer Highest vs lowest 0.94 (0.88-1.01) Incidence, colon cancer 0.93 (0.86-1.01)
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