> 27.1 vs < 23.8 1.15 (0.64-2.08) kg/m2 Ptrend:0.63 Women braf > 26.6 vs < 23.2 1.20 (0.50-2.87) 45/ mutated kg/m2 Ptrend:0.94 Men braf > 27.5 vs < 24.7 0.97 (0.39-2.44) 26/ mutated kg/m2 Ptrend:0.94 per 5 kg/m2 1.11 (1.01-1.21) Swedish 591/ Incidence, National 11 093 30 vs colorectal cancer ≥ 1.52 (1.20-1.93) Diabetes 9 years kg/m2 Swedish cancer Register Cohort Miao Jonasson, registry & Age, diabetes, 357/ per 5 kg/m2 1.10 (0.96-1.25) Study, Incidence, 2014 record linkage From registry diabetes Participants are Prospective colorectal 30 vs COL41049 with swedish records ≥ medication use, type 2 diabetes 263/ 1.62 (1.17-2.24) Cohort, cancer, men kg/m2 Sweden cause-of-death smoking patients Age: 30-90 registry 30 vs years, Incidence, ≥ 1.39 (0.98-1.96) kg/m2 M/W, 234/ colorectal Other cancer, women per 5 kg/m2 1.11 (0.99-1.26) Incidence, 1.67 (1.17-2.38) Q3 vs Q1 colorectal Ptrend:< 0.01 204/ cancer, igfbp 2 NLCS, Simons, 2014 genes per 5 kg/m2 1.39 (1.11-1.74) Case Cohort, COL41029 methylated Cancer registry Age: 55-69 Netherlands years 1.11 (0.77-1.62) Q3 vs Q1 Igfbp 1 gene Ptrend:0.57 178/ methylated per 5 kg/m2 1.19 (0.93-1.71)
> 27.1 vs < 23.8 kg/m2 1.15 (0.64-2.08) Ptrend:0.63 45/ Women braf mutated > 26.6 vs < 23.2 kg/m2 1.20 (0.50-2.87) Ptrend:0.94 26/ Men braf mutated > 27.5 vs < 24.7 kg/m2 0.97 (0.39-2.44) Ptrend:0.94 Miao Jonasson, 2014 COL41049 Sweden Swedish National Diabetes Register Cohort Study, Prospective Cohort, Age: 30-90 years, M/W, Other 591/ 11 093 9 years Swedish cancer registry & record linkage with swedish cause-of-death registry From registry records Incidence, colorectal cancer per 5 kg/m2 1.11 (1.01-1.21) Age, diabetes, diabetes medication use, smoking Participants are type 2 diabetes patients ≥ 30 vs kg/m2 1.52 (1.20-1.93) 357/ Incidence, colorectal cancer, men per 5 kg/m2 1.10 (0.96-1.25) 263/ ≥ 30 vs kg/m2 1.62 (1.17-2.24) 234/ Incidence, colorectal cancer, women ≥ 30 vs kg/m2 1.39 (0.98-1.96) per 5 kg/m2 1.11 (0.99-1.26) Simons, 2014 COL41029 Netherlands NLCS, Case Cohort, Age: 55-69 years 204/ Cancer registry Incidence, colorectal cancer, igfbp 2 genes methylated Q3 vs Q1 1.67 (1.17-2.38) Ptrend:< 0.01 per 5 kg/m2 1.39 (1.11-1.74) 178/ Igfbp 1 gene methylated Q3 vs Q1 1.11 (0.77-1.62) Ptrend:0.57 per 5 kg/m2 1.19 (0.93-1.71)
CUP_colorectal_SLR_2016_RO.docx