Table 114 Total milk intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure Adjustment WCRF Code, Outcome Comparison RR (95%CI) derived for characteristics Follow-up ascertainment assessment factors Country analysis (years) Incidence, vs 0-8.9 ≥325 colorectal 0.81 (0.73-0.90) g/d cancer Incidence, colorectal per 200 g/day 0.94 (0.91 cancer Incidence, vs 0-8.9 ≥325 0.80 (0.70-0.91) cancer g/d Incidence, Murphy, 2013 Cancer per 200 g/d 0.93 (0.90-0.97) colon cancer COL41070 registries, EPIC, health Incidence, Prospective 4 513/ vs 0-8.9 ≥325 Insurance Dietary proximal colon 0.84 (0.69-1.02) Cohort, 477 122 g/d records, questionnaire cancer Age: 30- 11 years pathology rec M/W Incidence, & active follow proximal colon per 200 g/day 0.95 (0.89-1.01) up cancer Incidence, vs 0-8.9 ≥325 distal colon 0.78 (0.63-0.96) g/d cancer Incidence, distal colon per 200 g/day 0.94 (0.88-0.99) cancer Incidence, vs 0-8.9 ≥325 0.84 (0.70-0.99) rectal cancer g/d
Table 114 Total milk intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Adjustment factors Missing data derived for analysis Murphy, 2013 COL41070 EPIC, Prospective Cohort, Age: 30- M/W 4 513/ 477 122 11 years Cancer registries, health Insurance records, pathology rec & active follow up Dietary questionnaire Incidence, colorectal cancer ≥325 vs 0-8.9 g/d 0.81 (0.73-0.90) Incidence, colorectal cancer per 200 g/day 0.94 (0.91 Incidence, cancer ≥325 vs 0-8.9 g/d 0.80 (0.70-0.91) Incidence, colon cancer per 200 g/d 0.93 (0.90-0.97) Incidence, proximal colon cancer ≥325 vs 0-8.9 g/d 0.84 (0.69-1.02) Incidence, proximal colon cancer per 200 g/day 0.95 (0.89-1.01) Incidence, distal colon cancer ≥325 vs 0-8.9 g/d 0.78 (0.63-0.96) Incidence, distal colon cancer per 200 g/day 0.94 (0.88-0.99) Incidence, rectal cancer ≥325 vs 0-8.9 g/d 0.84 (0.70-0.99) analysis
CUP_colorectal_SLR_2016_RO.docx