Supplementary Table S1: Metrics for CAGI 4 warfarin challenge Prediction R2 Sum of Mean |z Mean Mean |z * Spearman rank Spearman rank squared score| coefficient of mean correlation (rho, p correlation (rho, variation coefficient of of predicted p value) of variation dose vs. actual predicted dose dose vs. IWPC dose IWPC Algorithm 0.35 16374 N/A N/A N/A N/A N/A Group 48 Prediction 0.05 24000 4.19 0.16 (0.17, 0.22) (0.31, 0.025) 1 0.68 Group 48 Prediction 0.18 20863 7.43 0.097 (0.45, 7.5e-04) (0.38, 0.0054) 2 0.72 Group 49 Prediction 0.06 9.88 0.072 (0.21, 0.12) (0.17, 0.21) 1 0.71 49 Prediction 2 0.05 15.01 0.078 1.17 (0.26, 0.053) (0.25, 0.068) Group 49 Prediction 0.06 23761 2.79 0.44 (0.22, 0.11) (0.32, 0.018) 3 1.23 Group 49 Prediction 0.10 22789 5.29 0.27 (0.33, 0.016) (0.43, 0.0015) 4 1.43 49 Prediction 5 0.08 23221 6.26 0.14 0.88 (0.26, 0.058) (0.32, 0.018) Group 49 Prediction 0.15 21405 1.69 0.34 (0.38, 0.0045) (0.44, 0.00091) 6 0.58 Group 50 Prediction 0.25 18997 1.60 0.29 (0.56, 1.6e-05) (0.33, 0.016) 1 0.47 Supplementary Figure S8: Predicted dose vs. actual dose using the IWPC equation
Supplementary Table S1: Metrics for CAGI 4 warfarin challenge Prediction R2 Sum of squared Mean |z score| Mean coefficient of variation Mean |z * mean coefficient of variation Spearman rank correlation (rho, p of predicted dose vs. actual dose Spearman rank correlation (rho, p value) of predicted dose vs. IWPC dose IWPC Algorithm 0.35 16374 N/A N/A N/A N/A N/A Group 48 Prediction 1 0.05 24000 4.19 0.16 0.68 (0.17, 0.22) (0.31, 0.025) Group 48 Prediction 2 0.18 20863 7.43 0.097 0.72 (0.45, 7.5e-04) (0.38, 0.0054) Group 49 Prediction 1 0.06 9.88 0.072 0.71 (0.21, 0.12) (0.17, 0.21) 49 Prediction 2 0.05 15.01 0.078 1.17 (0.26, 0.053) (0.25, 0.068) Group 49 Prediction 3 0.06 23761 2.79 0.44 1.23 (0.22, 0.11) (0.32, 0.018) Group 49 Prediction 4 0.10 22789 5.29 0.27 1.43 (0.33, 0.016) (0.43, 0.0015) 49 Prediction 5 0.08 23221 6.26 0.14 0.88 (0.26, 0.058) (0.32, 0.018) Group 49 Prediction 6 0.15 21405 1.69 0.34 0.58 (0.38, 0.0045) (0.44, 0.00091) Group 50 Prediction 1 0.25 18997 1.60 0.29 0.47 (0.56, 1.6e-05) (0.33, 0.016) Supplementary Figure S8: Predicted dose vs. actual dose using the IWPC equation
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