Table 332 Waist circumference and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analyses (years) Age, alcohol, diabetes, educational WHI, Self-report energy, Prospective verified by ethnicity, family Kabat, 2013 Cohort, 169/ reviewing history of Incidence, 94.1 vs 75.9 1.30 (0.82-2.07) Mid-point ≥ ≤ COL40965 Age: 50-79 11 124 medical and Measured colorectal colorectal cancer cm Ptrend:0.23 categories USA years, 12.9 years pathological cancer, HRT W, records by use, pack yrs of Postmenopausal physicians smoking, physical activity, randomisation Age at baseline, 622/ Incidence, 1.26 (0.93-1.72) alcohol 72 962 colorectal cancer Ptrend:0.43 consumption, 11 cigarette, SWHS, Incidence, colon 1.34 (0.89-2.00) educational 382/ Prospective Follow up cancer Ptrend:0.46 Li, 2013 level, energy Cohort, survey/cancer COL40937 Measured 85 vs < 70 cm intake, family ≥ Age: 40-70 registry/vital categories history of years, statistics registry colorectal W Incidence, rectal 1.17 (0.73-1.88) cancer, fruits, 240/ cancer Ptrend:0.73 Income, menopausal status, physical
Table 332 Waist circumference and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analyses Kabat, 2013 COL40965 USA WHI, Prospective Cohort, Age: 50-79 years, W, Postmenopausal 169/ 11 124 12.9 years Self-report verified by reviewing medical and pathological records by physicians Measured Incidence, colorectal cancer ≥ 94.1 vs ≤ 75.9 cm 1.30 (0.82-2.07) Ptrend:0.23 Age, alcohol, diabetes, educational energy, ethnicity, family history of colorectal cancer, HRT use, pack yrs of smoking, physical activity, randomisation Mid-point categories Li, 2013 COL40937 SWHS, Prospective Cohort, Age: 40-70 years, W 622/ 72 962 11 Follow up survey/cancer registry/vital statistics registry Measured Incidence, colorectal cancer ≥ 85 vs < 70 cm 1.26 (0.93-1.72) Ptrend:0.43 Age at baseline, alcohol consumption, cigarette, educational level, energy intake, family history of colorectal cancer, fruits, Income, menopausal status, physical categories 382/ Incidence, colon cancer 1.34 (0.89-2.00) Ptrend:0.46 240/ Incidence, rectal cancer 1.17 (0.73-1.88) Ptrend:0.73 analysis
CUP_colorectal_SLR_2016_RO.docx