Human Health Hazard Summary Table Phthalate Carcinogenicity Irritation & Repeated Dose Genetic Reproductive Developmental Toxicity Sensitisation Toxicity Toxicity Toxicity Toxicity Bis(2- Oral Skin irritation: Rat: No data 16-day repeat dose Rat: In vitro: methoxyethyl) Rat: Minimal NOAEL = not No data = not established phthalate LD50 = effects established Rat: NOAEL = 100 LOAEL (ip) = 291 mg/kg (DMEP) 3200-6400 In vivo: mg/kg bw Eye irritation: LOAEL = 100 Positive in mg/kg bw/d bw/d, Minimal mg/kg bw/d, dominant skeletal and visceral ↑ Dermal effects lethal assay LOAEL of 1000 variations haemoglobin ↓ Guinea pig: mg/kg bw/d, and haematocrit LD50 Skin testes weight, values ↓ >1171 sensitisation: sperm degeneration, mg/kg bw Negative and testes atrophy High doses: ↓ thymus and testes Inhalation weights; Rat, 6h: testicular atrophy LC50 >770- 1595 ppm increase; decrease. ↑: ↓:
Human Health Hazard Summary Table Phthalate Toxicity Irritation & Sensitisation Repeated Dose Toxicity Genetic Toxicity Carcinogenicity Reproductive Toxicity Developmental Toxicity Bis(2- Oral Skin irritation: Rat: In vitro: No data 16-day repeat dose Rat: methoxyethyl) Rat: Minimal NOAEL = not No data = not established phthalate LD50 = effects established Rat: (DMEP) 3200-6400 In vivo: NOAEL = 100 LOAEL (ip) = 291 mg/kg mg/kg bw Eye irritation: LOAEL = 100 Positive in mg/kg bw/d bw/d, Minimal mg/kg bw/d, dominant ↑ skeletal and visceral Dermal effects ↓ haemoglobin lethal assay LOAEL of 1000 variations Guinea pig: and haematocrit mg/kg bw/d, LD50 Skin values ↓ testes weight, >1171 sensitisation: sperm degeneration, mg/kg bw Negative High doses: ↓ and testes atrophy thymus and testes Inhalation weights; Rat, 6h: testicular atrophy LC50 >770- 1595 ppm ↑: increase; ↓: decrease.
DMEP-hazard-assessment.docx