Table 315 Energy intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country 394/ vs ≥1844 Incidence, 1.20 (0.90-1.60) 73 224 ≤1406.9 colorectal cancer Ptrend:0.08 SWHS, 7.4 years kcal/day Cancer registry Prospective Lee, 2009 and death vs ≥1844 Cohort, Quantitative Age, energy Incidence, colon 1.40 (1.00-2.00) COL40764 certificates and 236/ ≤1406.9 Age: 40-70 FFQ intake cancer Ptrend:0.06 China participant kcal/day years, contact W vs ≥1844 Incidence, rectal 1.00 (0.60-1.50) 158/ ≤1406.9 cancer Ptrend:0.69 kcal/day Age-underlying cox models, alcohol, family Q 4 vs Q 1 1.51 (1.03-2.21) WHI, Self-report, history of colon Prospective medical record Incidence, colon cancer, history Prentice, 2009 Cohort, 363/ and pathology cancer, dm of polyp COL40811 Age: 50-79 80 816 report reviewed FFQ and observation diagnosis, USA years, 11.3 years by centrally study Intervention W, trained per 20 % assignment, 1.47 (1.11-1.94) Postmenopausal physician kcal/day physical activity, race, smoking status SCHS, Age, sex, Prospective alcohol intake, Butler, 2008 961/ Cohort, Incidence, 0.97 (0.80-1.18) BMI, diabetes, COL40639 61 321 Cancer registry FFQ Q 4 vs Q 1 Age: 45-74 colorectal cancer Ptrend:0.77 dialect Singapore 9.8 years years, educational M/W level, energy
Table 315 Energy intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Study size Follow-up Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Lee, 2009 COL40764 China SWHS, Prospective Cohort, Age: 40-70 years, W 394/ 73 224 7.4 years Cancer registry and death certificates and participant contact Quantitative FFQ Incidence, colorectal cancer ≥1844 vs ≤1406.9 kcal/day 1.20 (0.90-1.60) Ptrend:0.08 Age, energy intake 236/ Incidence, colon cancer ≥1844 vs ≤1406.9 kcal/day 1.40 (1.00-2.00) Ptrend:0.06 158/ Incidence, rectal cancer ≥1844 vs ≤1406.9 kcal/day 1.00 (0.60-1.50) Ptrend:0.69 Prentice, 2009 COL40811 USA WHI, Prospective Cohort, Age: 50-79 years, W, Postmenopausal 363/ 80 816 11.3 years Self-report, medical record and pathology report reviewed by centrally trained physician FFQ Incidence, colon cancer, dm and observation study Q 4 vs Q 1 1.51 (1.03-2.21) Age-underlying cox models, alcohol, family history of colon cancer, history of polyp diagnosis, Intervention assignment, physical activity, race, smoking status per 20 % kcal/day 1.47 (1.11-1.94) Butler, 2008 COL40639 Singapore SCHS, Prospective Cohort, Age: 45-74 years, M/W 961/ 61 321 9.8 years Cancer registry FFQ Incidence, colorectal cancer Q 4 vs Q 1 0.97 (0.80-1.18) Ptrend:0.77 Age, sex, alcohol intake, BMI, diabetes, dialect educational level, energy analysis
CUP_colorectal_SLR_2016_RO.docx