Table 241 Multivitamin supplements and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) WCRF Code, Outcome Comparison Adjustment factors characteristics Follow-up ascertainment assessment Ptrend Country (years) Hutchinson, UKWCS, 362/ National Questionnaire Incidence, 2014 Prospective 32 665 statistics office colorectal cancer Vitamins, minerals, fish oils or other COL41052 Cohort, 15 years food supplements UK Age: 33-74 (14% of the 8915 Age, alcohol, BMI, users vs non years, women who were 1.13 (0.87-1.46) educational level, users W currently taking exercise, smoking supplements at the second survey, were taking calcium supplements on a daily basis) Age at baseline, BMI, Park, 2011 MEC, 1 494/ Surveillance Questionnaire Incidence educational level, COL40853 Prospective 182 099 registry/end colorectal use vs no use 1.08 (0.66-1.75) Multivitamins: with energy from fat, USA Cohort, results cancer cancer, men or without minerals, ethnicity, family Age: 45-75 registry at least weekly 1 292/ Women history of colorectal years, cancer, fruit intake, M/W, Single supplement use: one or more of HRT use, menopausal Japanese, vitamin A, vitamin status, physical Caucasian, or C, vitamin E, activity, pre-existing Hawaiian calcium, use vs no use 0.71 (0.43-1.18) disease, smoking selenium, or iron at status, single least once a week during the past year. supplement use, vegetable intake, yogurt consumption Lee, 2011 NHS+HPFS 2299/ Self-reported FFQ Incidence, Age, calendar year, USA 87891men and and medical colorectal cancer pack-years of smoking women records Multivitamins years vs before age 30 y, ≥20 0.77(0.64-0.94) (no details) never physical activity, aspirin dose, height, BMI, family
Table 241 Multivitamin supplements and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Hutchinson, 2014 COL41052 UK UKWCS, Prospective Cohort, Age: 33-74 years, W 362/ 32 665 15 years National statistics office Questionnaire Vitamins, minerals, fish oils or other food supplements (14% of the 8915 women who were currently taking supplements at the second survey, were taking calcium supplements on a daily basis) Incidence, colorectal cancer users vs non users 1.13 (0.87-1.46) Age, alcohol, BMI, educational level, exercise, smoking Park, 2011 COL40853 USA MEC, Prospective Cohort, Age: 45-75 years, M/W, Japanese, Caucasian, or Hawaiian 1 494/ 182 099 Surveillance registry/end results cancer registry Questionnaire Multivitamins: with or without minerals, at least weekly Single supplement use: one or more of vitamin A, vitamin C, vitamin E, calcium, selenium, or iron at least once a week during the past year. Incidence colorectal cancer, men use vs no use 1.08 (0.66-1.75) Age at baseline, BMI, educational level, energy from fat, ethnicity, family history of colorectal cancer, fruit intake, HRT use, menopausal status, physical activity, pre-existing disease, smoking status, single supplement use, vegetable intake, yogurt consumption 1 292/ Women use vs no use 0.71 (0.43-1.18) Lee, 2011 USA NHS+HPFS 2299/ 87891men and women Self-reported and medical records FFQ Multivitamins (no details) Incidence, colorectal cancer ≥20 years vs never 0.77(0.64-0.94) Age, calendar year, pack-years of smoking before age 30 y, physical activity, aspirin dose, height, BMI, family
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