folate supplement Age, educational level, household income, BMI, smoking, HRT use, drinking status, physical activity, menopausal status, family SWHS, Cancer history Distribution of Shrubsole, 2009 Prospective 394/ registry/death Incidence, 419 vs 213 colorectal person-years by COL40773 Cohort, FFQ 1.10 (0.80-1.70) 72 861 colorectal cancer mcg/day cancer, NSAID exposure China Age: 40-70 use, B vitamin category. W supplement, history of colorectal polyps, diabetes, intakes of energy, fruits, vegetables, red meats, and calcium Age, alcohol, Distribution of Prospective Record linkages BMI, calories person-years by Cohort, to cancer intake, Kabat, 2008 617/ exposure Age: 40-59 database and to Incidence, vs educational ≥374 ≤236 COL40636 49 654 86 items FFQ 0.89 (0.68-1.17) category. years, the national colorectal cancer mcg/day level, HRT use, Canada 16.4 years of W, mortality menopausal exposure Screening database status, oral categories. Program contraceptive
folate supplement Shrubsole, 2009 COL40773 China SWHS, Prospective Cohort, Age: 40-70 W 394/ 72 861 Cancer registry/death FFQ Incidence, colorectal cancer 419 vs 213 mcg/day 1.10 (0.80-1.70) Age, educational level, household income, BMI, smoking, HRT use, drinking status, physical activity, menopausal status, family history colorectal cancer, NSAID use, B vitamin supplement, history of colorectal polyps, diabetes, intakes of energy, fruits, vegetables, red meats, and calcium Distribution of person-years by exposure category. Kabat, 2008 COL40636 Canada Prospective Cohort, Age: 40-59 years, W, Screening Program 617/ 49 654 16.4 years Record linkages to cancer database and to the national mortality database 86 items FFQ Incidence, colorectal cancer ≥374 vs ≤236 mcg/day 0.89 (0.68-1.17) Age, alcohol, BMI, calories intake, educational level, HRT use, menopausal status, oral contraceptive Distribution of person-years by exposure category. of exposure categories.
CUP_colorectal_SLR_2016_RO.docx