Problem No The evidence used to answer this question comes from 1 Although no open label Is there a ○ problem priority? Probably no RCT: Al-Quadheeb 2016 . This evidence revealed no haloperidol was used in ○ Uncertain statistically significant effect of haloperidol compared to this study, the numbers of ○ Probably yes placebo treatment with regard to incidence, duration, days participants was small and ○ Yes of mechanical ventilation, ICU length of stay, or delirium included 34 in both ● Varies duration. the haloperidol and placebo ○ arms. Benefits & harms of No included studies What is the ○ the options overall certainty Very low The relative importance or values of ○ of this evidence? Low of interest: ● Moderate ○ High ○ Is there Important uncertainty ○ important or variability uncertainty about Possibly important ○ how much people uncertainty or value the main variability outcomes? Probably no ● important uncertainty or variability No important ○ uncertainty or variability
Problem Is there a problem priority? ○ No ○ Probably no ○ Uncertain ○ Probably yes ● Yes ○ Varies The evidence used to answer this question comes from 1 RCT: Al-Quadheeb 2016 . This evidence revealed no statistically significant effect of haloperidol compared to placebo treatment with regard to incidence, duration, days of mechanical ventilation, ICU length of stay, or delirium duration. Although no open label haloperidol was used in this study, the numbers of participants was small and included 34 in both the haloperidol and placebo arms. Benefits & harms of the options What is the overall certainty of this evidence? ○ No included studies ○ Very low ● Low ○ Moderate ○ High The relative importance or values of of interest: Is there important uncertainty about how much people value the main outcomes? ○ Important uncertainty or variability ○ Possibly important uncertainty or variability ● Probably no important uncertainty or variability ○ No important uncertainty or variability
CCM_46_9_2018_06_08_DEVLIN_CCMED-D-18-00069_SDC26.docx