Supplementary Figure 1 Supplementary Table S1 Histological scoring system1 Evaluated parameters Points Extracellular matrix (ECM) organization of the whole tendon Wavy, compact and parallel arranged collagen fibers 2 In part compact, in part loose or not orderly 1 Loosely composed, not orderly (“granulation” tissue) 0 Proteoglycan content (Safranin Orange staining) Normal 1 Focally increased 0 Physiological 2 Locally increased cell density 1 Increased cell density or decreased ECM content 0 Cell alignment Uniaxial 2 Areas of irregularly arranged cells (10-50%) 1 More than 50% of cells with no uniaxial alignment 0 Cell distribution Homogeneous, physiological 1 Focal areas of elevated cell density (cell clustering) 0
Supplementary Figure 1 Supplementary Table S1 Histological scoring system1 Evaluated parameters Points Extracellular matrix (ECM) organization of the whole tendon Wavy, compact and parallel arranged collagen fibers In part compact, in part loose or not orderly Loosely composed, not orderly (“granulation” tissue) 2 1 0 Proteoglycan content (Safranin Orange staining) Normal Focally increased 1 0 Physiological Locally increased cell density Increased cell density or decreased ECM content 2 1 0 Cell alignment Uniaxial Areas of irregularly arranged cells (10-50%) More than 50% of cells with no uniaxial alignment 2 1 0 Cell distribution Homogeneous, physiological Focal areas of elevated cell density (cell clustering) 1 0
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