How substantial are the desirable There was a consistent message with about a anticipated effects? day shorter on mechanical ventilation but no difference in most other outcomes. Similar to the alpha2 vs benzo comparisons the Jakob Small ● PRODEX [6] study's eval of delirium was considered difficult to interpret because of its Effects distant measurement. With regards to ICU Desirable LOS wide CI. So really only difference was small diff in MV How substantial are the undesirable Bradycardia was not different and the anticipated effects? hypotension was not diffferent so no real undersirable effect differences Trivial ● Effects e What is the overall certainty of the evidence of effects? evidence Low ● Certainty of Is there important uncertainty about or With a small difference in MV and no difference variability in how much people value in undersiable effects effects the patient rep the main outcomes? felt most would not have any uncertainty on Probably no important uncertainty or what they would prefer ● Values Does the balance between desirable and undesirable effects favor the intervention or the comparison? Probably favors the intervention ● effects Balance of
Desirable Effects How substantial are the desirable anticipated effects? ● Small There was a consistent message with about a day shorter on mechanical ventilation but no difference in most other outcomes. Similar to the alpha2 vs benzo comparisons the Jakob PRODEX [6] study's eval of delirium was considered difficult to interpret because of its distant measurement. With regards to ICU LOS wide CI. So really only difference was small diff in MV e Effects How substantial are the undesirable anticipated effects? ● Trivial Bradycardia was not different and the hypotension was not diffferent so no real undersirable effect differences Certainty of evidence What is the overall certainty of the evidence of effects? ● Low Values Is there important uncertainty about or variability in how much people value the main outcomes? ● Probably no important uncertainty or With a small difference in MV and no difference in undersiable effects effects the patient rep felt most would not have any uncertainty on what they would prefer Balance of effects Does the balance between desirable and undesirable effects favor the intervention or the comparison? ● Probably favors the intervention
CCM_46_9_2018_06_08_DEVLIN_CCMED-D-18-00069_SDC15.docx