a single-component non-pharmacologic strategy that is not focused on sleep improvement or early of Study no such Relative Absolute № Risk of bias Inconsistency Indirectness Imprecision Other considerations mobilization, reduce studies design intervention (95% CI) (95% CI) delirium (incidence/prevalence, LOS-ICU, hospital mortality or other outcomes) Delirium incidence/prevalence (Taguchi 2007) 1 randomised serious a not serious not serious very serious b none 2/5 (40.0%) 1/6 (16.7%) RR 0.31 115 per 1,000 IMPORTANT trials (-- to --) (from -- to --) VERY LOW Delirium incidence/prevalence (Lee, 2013) 1 observational serious not serious serious very serious c none 6/49 (12.2%) 16/46 (34.8%) RR 0.35 226 fewer per 1,000 IMPORTANT studies (0.15 to (from 63 fewer to VERY LOW 0.82) 296 fewer) Delirium incidence/prevalence (Black, 2011) 1 observational serious not serious serious serious d none 23/79 (29.1%) 54/70 (77.1%) RR 0.38 478 per 1,000 IMPORTANT studies (0.26 to (from 355 fewer to 571 VERY LOW 0.54) fewer) Delirium incidence (Simons, 2016) 1 randomised not serious not serious not serious not serious e none 137/361 (38.0%) 123/373 RR 1.15 49 more per 1,000 IMPORTANT ⨁⨁⨁⨁ trials (33.0%) (0.95 to 1.40) (from 16 to 132 HIGH more) Delirium incidence/prevalence (Ono, 2011) 1 randomised very serious serious serious very serious none 1/10 (10.0%) 5/12 (41.7%) not estimable trials VERY LOW
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations a single-component non-pharmacologic strategy that is not focused on sleep improvement or early mobilization, reduce delirium (incidence/prevalence, LOS-ICU, hospital mortality or other outcomes) no such intervention Relative (95% CI) Absolute (95% CI) Delirium incidence/prevalence (Taguchi 2007) 1 randomised trials serious a not serious not serious very serious b none 2/5 (40.0%) 1/6 (16.7%) RR 0.31 (-- to --) 115 per 1,000 (from -- to --) VERY LOW IMPORTANT Delirium incidence/prevalence (Lee, 2013) 1 observational studies serious not serious serious very serious c none 6/49 (12.2%) 16/46 (34.8%) RR 0.35 (0.15 to 0.82) 226 fewer per 1,000 (from 63 fewer to 296 fewer) VERY LOW IMPORTANT Delirium incidence/prevalence (Black, 2011) 1 observational studies serious not serious serious serious d none 23/79 (29.1%) 54/70 (77.1%) RR 0.38 (0.26 to 0.54) 478 per 1,000 (from 355 fewer to 571 fewer) VERY LOW IMPORTANT Delirium incidence (Simons, 2016) 1 randomised trials not serious not serious not serious not serious e none 137/361 (38.0%) 123/373 (33.0%) RR 1.15 (0.95 to 1.40) 49 more per 1,000 (from 16 to 132 more) ⨁⨁⨁⨁ HIGH IMPORTANT Delirium incidence/prevalence (Ono, 2011) 1 randomised trials very serious serious serious very serious none 1/10 (10.0%) 5/12 (41.7%) not estimable VERY LOW
CCM_46_9_2018_06_08_DEVLIN_CCMED-D-18-00069_SDC26.docx