1 13 4 12 6 3 12 9 Neurogenesis 31 29 26 1 23 7 21 8 2 9 Neuronal 8 7 2 5 5 16 12 14 12 15 3 8 3 2 6 differentiation Endpoint 1 neuronal 3 2 2 3 2 3 - - 2  1 differentiation 2 10 1 4 1 8 4 Neuronal ion 24 16 20 channel 16 2 17 10 5 1 11 Neuronal 2 6 2 2 1 2 1 signal 7 7 2 3 1 4 5 5 4 5 transduction Table S6. Fold change in gene expression in undifferentiated and differentiating CC9 cells harbouring Mus musculus, pahari and dunni mtDNA following initial culture with 5-Aza. Arrows indicate up and down regulation, respectively. No. of CC9mus CC9mus CC9mus CC9pahari CC9pahari CC9pahari CC9dunni CC9dunni CC9dunni 5-Aza genes Day 0 Day 3 Day 21 Day 0 Day 3 Day 21 Day 0 Day 3 Day 21 Regulators of 2 3 2 DNA 6 6 Na 6 6 - 5   3 1 3 methylation 2 5 5 2 Na 4 4 5 - 5 transcription    2 and
Neurogenesis 31 1 26 13 1 29 4 23 12 7 6 21 3 8 12 2 9 9 Neuronal differentiation 16 12 8 3 14 12 7 8 15 2 3 5 2 5 6 Endpoint neuronal differentiation 3 2 2  3 2 1 1 3 - - 2 Neuronal ion channel 24 2 16 10 2 16 1 17 4 10 20 1 5 8 1 4 11 Neuronal signal transduction 7 2 3 6 1 7 2 4 2 5 1 5 2 2 4 1 5 Table S6. Fold change in gene expression in undifferentiated and differentiating CC9 cells harbouring Mus musculus, pahari and dunni mtDNA following initial culture with 5-Aza. Arrows indicate up and down regulation, respectively. 5-Aza No. of genes CC9mus Day 0 CC9mus Day 3 CC9mus Day 21 CC9pahari Day 0 CC9pahari Day 3 CC9pahari Day 21 CC9dunni Day 0 CC9dunni Day 3 CC9dunni Day 21 Regulators of DNA methylation 6 6  2 3 Na 6  3 1 6 - 5 2 3 transcription and 5 5  2 Na 4  4  5 - 5 2 2
cddiscovery201762-s1.docx