Lymphomas or chronic lymphocytic leukemias Lymphoid tumors are examples of ___. Where do lymphoid tumors arise? From less mature stages in B-lymphocyte development What is a malignant proliferation of Waldenstroms Macroglobulinemia plasmacytoid cells producing IgM? What causes hyperviscosity that may require IgM and IgM paraproteins treatment by plasma exchange? What is the rare disorder in which a free Ig Heavy Chain disease heavy chain is produced? What is the most common form of Heavy Alpha chain disease Chain disease? What is chain disease associated with? The heavy chain of IgA What can cause malabsorption in alpha chain Intestinal infiltration with clonal lymphocytes disease? What are serum proteins or protein complexes Cryoglobulins that precipitate at a temperature lower than normal core body temperature? What is the result of precipitation in tissues? Vasculitis and ischemic injury to peripheral tissues of the lower temperature How do you lower a patient's cryoglobulin Patient must be kept in a warm environment concentrations? What do type I cryoglobulins consist of? Monoclonal immunoglobulins, often IgM How many days are serum usually refrigerated 7 days for cryoglobulin analysis? What is the next step after 7 days? Centrifugation What happens when cryoglobulins that They should redissolve precipitated in the cold are warmed back to 37C? What is a pathological process in which Amyloidosis proteins are deposited in tissues as aggregates (amyloid), and form b-sheet structures? What can result from amyloidosis? Kidney failure, heart failure, and peripheral neuropathies What are stable structures resistant to Aggregates proteolysis and normal clearance mechanisms? Aggregates accumulate over time. TRUE What happens when there is increased Formation of amyloid production of specific proteins, genetic variants of proteins, or fragments of proteins? Where are the tissues obtained in order to From fat aspirates, rectal biopsy specimens, or diagnose amyloidosis? biopsy specimens of affected tissues What can the b-sheet structure of the amyloid Congo red dye be stained with? What occurs as the result of increased AL amyloidosis concentrations of proteins including...
Lymphomas or chronic lymphocytic leukemias are examples of ___. Lymphoid tumors Where do lymphoid tumors arise? From less mature stages in B-lymphocyte development What is a malignant proliferation of plasmacytoid cells producing IgM? Waldenstroms Macroglobulinemia What causes hyperviscosity that may require treatment by plasma exchange? IgM and IgM paraproteins What is the rare disorder in which a free Ig heavy chain is produced? Heavy Chain disease What is the most common form of Heavy Chain disease? Alpha chain disease What is chain disease associated with? The heavy chain of IgA What can cause malabsorption in alpha chain disease? Intestinal infiltration with clonal lymphocytes What are serum proteins or protein complexes that precipitate at a temperature lower than normal core body temperature? Cryoglobulins What is the result of precipitation in tissues? Vasculitis and ischemic injury to peripheral tissues of the lower temperature How do you lower a patient's cryoglobulin concentrations? Patient must be kept in a warm environment What do type I cryoglobulins consist of? Monoclonal immunoglobulins, often IgM How many days are serum usually refrigerated for cryoglobulin analysis? 7 days What is the next step after 7 days? Centrifugation What happens when cryoglobulins that precipitated in the cold are warmed back to 37C? They should redissolve What is a pathological process in which proteins are deposited in tissues as aggregates (amyloid), and form b-sheet structures? Amyloidosis What can result from amyloidosis? Kidney failure, heart failure, and peripheral neuropathies What are stable structures resistant to proteolysis and normal clearance mechanisms? Aggregates Aggregates accumulate over time. TRUE What happens when there is increased production of specific proteins, genetic variants of proteins, or fragments of proteins? Formation of amyloid Where are the tissues obtained in order to diagnose amyloidosis? From fat aspirates, rectal biopsy specimens, or biopsy specimens of affected tissues What can the b-sheet structure of the amyloid be stained with? Congo red dye What occurs as the result of increased concentrations of proteins including... AL amyloidosis
ChemPPT%20Flashcards%20Unit%202.docx