CI) Pi 2 per per per Pi vs. (95% for attack. 1 4 range. for vs. 4 increase increase increase 1.00-1.25mM Pi Pi Pi Increase quartile (1.02-1.18) (1.17-2.59) (1.27–2.40) (1.22–2.45) (1.20-2.14) vs. normal ischaemic (1.07-1.55) Pi Risk quartile (1.09-1.73) 1.10 1.74 1.75 1.73 1.61 the for 1.29 0.32mM 0.32mM 0.32mM OR HR HR HR 1.38 HR transient HR within Adjusted TIA, cardiac infarction; procedure incident TIA, concentrations mortality failure myocardial mortality, calcification MI, infarction, heart Mortality Mortality phosphate Outcome revascularisation failure/MI/stroke outcome; Clinical Coronary Cardiovascular serum myocardial deviation; coronary by Composite stroke, standard failure, mortality SD, or 7y 4y 6y 30y 17y F/U 2.5y phosphate; N 883 outcomes Pi, 2,176 3,300 1,663 10,743 24,184 ratio; 49 only and heart odds Pi with Normal age males OR, infarction population cardiovascular infarction mean disease, ratio; function. phosphatase representative creatinine, cohort; population. outpatients of myocardial Population adults, kidney community myocardial renal reporting hazard or alkaline Medical HR, Nationally Post Healthy measures without Community Healthy community failure Studies interval; (cont.) 1.1 year 2010 2010 2013 2009 2013 2009 Tuttle Author Dhingra Larsson Aronson confidence McGovern Abramowitz CI,
1.1 (cont.) Studies reporting cardiovascular outcomes or mortality by serum phosphate concentrations within the normal range. Adjusted Risk Increase (95% CI) HR 1.10 (1.02-1.18) per 0.32mM Pi increase HR 1.29 (1.07-1.55) for Pi quartile 4 vs. 1 HR 1.38 (1.09-1.73) for Pi vs. 1.00-1.25mM HR 1.74 (1.17-2.59) per 0.32mM Pi increase HR for Pi quartile 4 vs. 2 1.75 (1.27–2.40) 1.73 (1.22–2.45) OR 1.61 (1.20-2.14) per 0.32mM Pi increase CI, confidence interval; HR, hazard ratio; OR, odds ratio; Pi, phosphate; SD, standard deviation; MI, myocardial infarction; TIA, transient ischaemic attack. Outcome Cardiovascular mortality Mortality Composite outcome; mortality, incident stroke, myocardial infarction, TIA, cardiac failure, coronary revascularisation procedure Clinical heart failure Mortality failure/MI/stroke Coronary calcification F/U 30y 7y 2.5y 17y 4y 6y N 2,176 10,743 24,184 3,300 1,663 883 Population Community cohort; males only Medical outpatients with measures of creatinine, Pi and alkaline phosphatase Nationally representative community population. Normal renal function. Healthy community population without kidney disease, heart failure or myocardial infarction Post myocardial infarction Healthy adults, mean age 49 Author year Larsson 2010 Abramowitz 2010 McGovern 2013 Dhingra 2009 Aronson 2013 Tuttle 2009
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