What are three clinical significances of LD3 Pulmonary edema when elevated? Pulmonary infarction Pancreatitis What are two clinical significances of LD4 and Liver disease LD5 when elevated? Skeletal muscle disease The LD isoenzyme pattern in renal disease is Absolute values very similar to a normal pattern except for the higher _____________? Define Diagnostic Window. The interval of time after an episode of injury during which plasma concentrations of the marker are increased, thereby demonstrating the occurrence of injury When does CK activity increase? 4-6 hours after the symptoms When does CK activity peak? 12-24 hours When does CK activity return to normal? 48-72 hours When does AST activity increase? 6-8 hours after the symptoms When does AST activity peak? 24-46 hours When does AST activity return to normal? 4th of 5th day When does LD activity increase? 8-12 hours after the symptoms When does LD activity peak? 48-60 hours How long does LD activity remain elevated? 10-14 days What does AMI stand for? Acute Myocardial Infarction What is a myoglobin? A heme protein that can bind oxygen reversibly found in cardiac and striated muscles How long does myoglobin take to increase 1-3 hours after infarction? How long does myoglobin take to double its 1-2 initial volume after infarction? When does myoglobin peak? 5-12 hours When does myoglobin return to normal? 18-30 hours What is myoglobin used in conjunction with to Troponin and CK-MB assess AMI? What is Troponin? A group of three proteins that function in muscle contraction by binding to the thin filaments of cardiac and skeletal muscles What are the 3 types of Troponin? Troponin T (TnT) Troponin I (Tn I) Troponin C (TnC) When does Cardiac troponin I (cTn I) increase 4-8 hours after an AMI? How long does Cardiac troponin I (cTn I) 3-5 days remain elevated after an AMI? When is a serial quantification of Cardiac 3-6 hours troponin I (cTn I) necessary after an AMI? 6-9 hours 12-24 hours interval
What are three clinical significances of LD3 when elevated? Pulmonary edema Pulmonary infarction Pancreatitis What are two clinical significances of LD4 and LD5 when elevated? Liver disease Skeletal muscle disease The LD isoenzyme pattern in renal disease is very similar to a normal pattern except for the higher _____________? Absolute values Define Diagnostic Window. The interval of time after an episode of injury during which plasma concentrations of the marker are increased, thereby demonstrating the occurrence of injury When does CK activity increase? 4-6 hours after the symptoms When does CK activity peak? 12-24 hours When does CK activity return to normal? 48-72 hours When does AST activity increase? 6-8 hours after the symptoms When does AST activity peak? 24-46 hours When does AST activity return to normal? 4th of 5th day When does LD activity increase? 8-12 hours after the symptoms When does LD activity peak? 48-60 hours How long does LD activity remain elevated? 10-14 days What does AMI stand for? Acute Myocardial Infarction What is a myoglobin? A heme protein that can bind oxygen reversibly found in cardiac and striated muscles How long does myoglobin take to increase after infarction? 1-3 hours How long does myoglobin take to double its initial volume after infarction? 1-2 When does myoglobin peak? 5-12 hours When does myoglobin return to normal? 18-30 hours What is myoglobin used in conjunction with to assess AMI? Troponin and CK-MB What is Troponin? A group of three proteins that function in muscle contraction by binding to the thin filaments of cardiac and skeletal muscles What are the 3 types of Troponin? Troponin T (TnT) Troponin I (Tn I) Troponin C (TnC) When does Cardiac troponin I (cTn I) increase after an AMI? 4-8 hours How long does Cardiac troponin I (cTn I) remain elevated after an AMI? 3-5 days When is a serial quantification of Cardiac troponin I (cTn I) necessary after an AMI? 3-6 hours 6-9 hours 12-24 hours interval
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