not on a specified list Mutagenicity/genotoxicity: – In vitro study on chemical OECD not on a specified list AND TG 471 AND in vitro or in vivo study - point In study using suitable – mutations in microbial systems do information – OECD 473 not indicate mutagenic/genotoxic effects AND in vitro or in vivo study – chromosome damage in mammalian cells - do not indicate mutagenic/genotoxic effects Hazard band B toxicity (fatal or toxic): In vivo acute oral toxicity study in vivo result – acute oral toxicity using suitable read-across LD50 > 300 mg/kg bw OR information – OECD TG 420 in vivo result – acute dermal toxicity LD50 > 1000 mg/kg bw OR – in vivo result acute inhalation toxicity LC50 > 2500ppmV (gases), or > 10 mg/L (vapours), or > 1 mg/L (dusts/mists/fumes) Specific target organ toxicity after a single exposure (significant toxicity): Not required Specific target organ toxicity after repeated exposure: – in vivo result 28 day oral toxicity: In vivo 28 day oral toxicity study NOAEL ≥ 300 mg/kg bw/day, or no using suitable read-across significant toxic effects relevant to information – OECD TG 407 humans OR
not on a specified list Mutagenicity/genotoxicity: not on a specified list AND in vitro or in vivo study - point mutations in microbial systems – do not indicate mutagenic/genotoxic effects AND in vitro or in vivo study – chromosome damage in mammalian cells - do not indicate mutagenic/genotoxic effects In vitro study on chemical – OECD TG 471 AND In study using suitable information – OECD 473 Hazard band B toxicity (fatal or toxic): in vivo result – acute oral toxicity LD50 > 300 mg/kg bw OR in vivo result – acute dermal toxicity LD50 > 1000 mg/kg bw OR in vivo result – acute inhalation toxicity LC50 > 2500ppmV (gases), or > 10 mg/L (vapours), or > 1 mg/L (dusts/mists/fumes) In vivo acute oral toxicity study using suitable read-across information – OECD TG 420 Specific target organ toxicity after a single exposure (significant toxicity): Not required Specific target organ toxicity after repeated exposure: in vivo result – 28 day oral toxicity: NOAEL ≥ 300 mg/kg bw/day, or no significant toxic effects relevant to humans OR In vivo 28 day oral toxicity study using suitable read-across information – OECD TG 407
Case-study-high-volume-surfactant-cosmetic.docx