deficiency is a temporary problem. The first clinical signs of juvenile demodicosis in dogs occur typically in the first 18 months of life. Adult-onset demodicosis also exists and is comparable to the demodicosis seen in other species. In the dog, this was reported to be associated with diseases or drugs leading to a compromised immune system such as leishmaniasis, hyperadrenocorticism,, hypothyroidism, neoplasia, babesiosis, ehrlichiosis, and glucocorticoid treatment or chemotherapy. One report mentioned atopic dermatitis as a frequent concurrent disease, but many dogs received glucocorticoid therapy. In cats, demodicosis has been reported in association with feline immunodeficiency virus,,, xanthoma, and diabetes mellitus. The localised form has been described in lesions of feline squmous cell carcinoma in situ., In humans, demodicosis is described as a primary immunosuppressive disorder based on a hereditary T cell defect or as a consequence of immunosuppression. Genetics of juvenile demodicosis For decades, strong breed predilections were reported for canine juvenile demodicosis. In early reports those lists were largely anecdotal. More recently, one larger study identified an at least four-fold increased risk to develop generalised demodicosis for the Affenpinscher, Briard, Bullnese, Dogue de Bordeaux, English Bulldog, French bull terrier, Pit bull terrier, Presa canario, Pug and West Highland White Terrier., A further multi-centered and well-powered study in the United States identified the American Staffordshire terrier, Staffordshire bull terrier and Chinese shar-pei as predisposed breeds. Those breed predilections and the frequent occurrence of juvenile demodicosis in certain lines, sibling puppies and related dogs make a hereditary basis very likely. In addition, there is anecdotal evidence that preventing affected dogs from breeding decreases the frequency of the disease. However, to the authors' knowledge only one study has been published evaluating the genetic basis in more detail. In this study using microsatellite markers, a significant association was found between generalised demodicosis and the DLA haplotypes FH2002, FH2975 and FH2054 in Argentinian mastiffs and Boxers.
deficiency is a temporary problem. The first clinical signs of juvenile demodicosis in dogs occur typically in the first 18 months of life. Adult-onset demodicosis also exists and is comparable to the demodicosis seen in other species. In the dog, this was reported to be associated with diseases or drugs leading to a compromised immune system such as leishmaniasis, hyperadrenocorticism,, hypothyroidism, neoplasia, babesiosis, ehrlichiosis, and glucocorticoid treatment or chemotherapy. One report mentioned atopic dermatitis as a frequent concurrent disease, but many dogs received glucocorticoid therapy. In cats, demodicosis has been reported in association with feline immunodeficiency virus,,, xanthoma, and diabetes mellitus. The localised form has been described in lesions of feline squmous cell carcinoma in situ., In humans, demodicosis is described as a primary immunosuppressive disorder based on a hereditary T cell defect or as a consequence of immunosuppression. Genetics of juvenile demodicosis For decades, strong breed predilections were reported for canine juvenile demodicosis. In early reports those lists were largely anecdotal. More recently, one larger study identified an at least four-fold increased risk to develop generalised demodicosis for the Affenpinscher, Briard, Bullnese, Dogue de Bordeaux, English Bulldog, French bull terrier, Pit bull terrier, Presa canario, Pug and West Highland White Terrier., A further multi-centered and well-powered study in the United States identified the American Staffordshire terrier, Staffordshire bull terrier and Chinese shar-pei as predisposed breeds. Those breed predilections and the frequent occurrence of juvenile demodicosis in certain lines, sibling puppies and related dogs make a hereditary basis very likely. In addition, there is anecdotal evidence that preventing affected dogs from breeding decreases the frequency of the disease. However, to the authors' knowledge only one study has been published evaluating the genetic basis in more detail. In this study using microsatellite markers, a significant association was found between generalised demodicosis and the DLA haplotypes FH2002, FH2975 and FH2054 in Argentinian mastiffs and Boxers.
clinical-consensus-guidelines-demodicosis.docx