administrated once daily for 3 weeks [425], there is insufficient evidence to comment specifically on the efficacy of the various doses used (5 or 10 mg/kg, once or twice daily). Reports of improved efficacy with KTZ at doses of 10 mg/kg twice daily [390](Mason and Stewart 1993) do not appear to have been subjected to critical comparative trials. Adverse reactions are regularly reported with the use of ketoconazole in dogs; a retrospective study of 632 dogs that received a median daily dose of 10 mg/kg reported adverse effects in 14.6%, including primarily vomiting (7.1%), anorexia (4.9%), lethargy (1.9%) and diarrhoea (1.1%).[426] Adverse effects were significantly more frequent in dogs receiving concurrent ivermectin or ciclosporin.
administrated once daily for 3 weeks [425], there is insufficient evidence to comment specifically on the efficacy of the various doses used (5 or 10 mg/kg, once or twice daily). Reports of improved efficacy with KTZ at doses of 10 mg/kg twice daily [390](Mason and Stewart 1993) do not appear to have been subjected to critical comparative trials. Adverse reactions are regularly reported with the use of ketoconazole in dogs; a retrospective study of 632 dogs that received a median daily dose of 10 mg/kg reported adverse effects in 14.6%, including primarily vomiting (7.1%), anorexia (4.9%), lethargy (1.9%) and diarrhoea (1.1%).[426] Adverse effects were significantly more frequent in dogs receiving concurrent ivermectin or ciclosporin.
clinical-consensus-guidelines-diagnosis-treatment-malessezia-dermatitis.docx