Isolated as an oil. Following method F, 155 mg used (64 mg, 47 %). Following method G, 0.11 mL N-(2-(thiophen-2-yl)ethyl)formamide used (77 mg, 56 %). Rf (1:19 ethyl acetate:hexanes) = 0.8; max (film/cm-1) = 3110, 3075, 2925, 2150, 1735, ν 1450, 1435; 1H NMR (250 MHz, CDCl3) = 7.25-7.21 (1H, m), 7.01-6.97 (2H, m), 3.66 (2H, t J δ = 7 Hz), 3.23 (2H, t J = 7 Hz); 13C NMR (400 MHz, CDCl3) = 151.4, 138.4, 127.2, 126.2, δ 124.7, 43.2, 30.0; HRMS (ES) found 137.0298 C7H7NSH+ requires 137.0299. ethyl 2-isocyanoacetate 165127 Isolated as an oil. Following method G, 131 mg ethylformylglycinate used (14 mg, 12 %). Rf (1:19 ethyl acetate:hexanes) = 0.8; max (film/cm-1) =3050, 3035, 2145, 1740; 1H NMR ν (400 MHz, CDCl3) = 4.31 (2H, q = 7 Hz), 4.24 (2H, s), 1.34 (3H, t = 7 Hz); HRMS (ES) found J J δ 114.0555 C7H11NH+ requires 114.0550; Data is in accordance with literature.127 Experimental data for chapter 5 Experimental procedures for the synthesis of preparation of imidazo-[1,2α]-pyrimidines (method J)
Isolated as an oil. Following method F, 155 mg used (64 mg, 47 %). Following method G, 0.11 mL N-(2-(thiophen-2-yl)ethyl)formamide used (77 mg, 56 %). Rf (1:19 ethyl acetate:hexanes) = 0.8; ν max (film/cm-1) = 3110, 3075, 2925, 2150, 1735, 1450, 1435; 1H NMR (250 MHz, CDCl3) δ = 7.25-7.21 (1H, m), 7.01-6.97 (2H, m), 3.66 (2H, t J = 7 Hz), 3.23 (2H, t J = 7 Hz); 13C NMR (400 MHz, CDCl3) δ = 151.4, 138.4, 127.2, 126.2, 124.7, 43.2, 30.0; HRMS (ES) found 137.0298 C7H7NSH+ requires 137.0299. ethyl 2-isocyanoacetate 165127 Isolated as an oil. Following method G, 131 mg ethylformylglycinate used (14 mg, 12 %). Rf (1:19 ethyl acetate:hexanes) = 0.8; ν max (film/cm-1) =3050, 3035, 2145, 1740; 1H NMR (400 MHz, CDCl3) δ = 4.31 (2H, q J = 7 Hz), 4.24 (2H, s), 1.34 (3H, t J = 7 Hz); HRMS (ES) found 114.0555 C7H11NH+ requires 114.0550; Data is in accordance with literature.127 Experimental data for chapter 5 Experimental procedures for the synthesis of preparation of imidazo-[1,2α]-pyrimidines (method J)
Complete_thesis_with_corrections.docx