MSH is melanocyte stimulating hormone controls pigment cells. This causes patient to have hyperpigmentation only in primary Addison’s disease. THIS DOESN’T happen in secondary Addison’s. Treatment Replace all these three hormones and solve problem Remove tumor if problem Treat infection with antibiotic Deal with autoimmune Secondary Addison’s disease Exists in hypothalamus or anterior lobe of pituitary Autoimmune Destruction Leads to decreased ACTH and CRH which decreases all three hormones from adrenal cortex. There is no feedback since no increase or decreases in peripheral hormones so no hyperpigmentation in patient Treatment is to replace hormones Cushing’s syndrome increases in hormones from adrenal cortex Primary Patient has tumor in adrenal cortex which leads to over secretion of three hormones (peripheral hormones). Increased peripheral decreases central hormones ACTH and decreases CRH (corticotropin releasing hormone) Secondary Case is high level of ACTH or high level of CRH which lead to increase in three hormones. CRH increases ACTH which increases three hormones from adrenal cortex. Overproduction of adrenal cortex hormones in primary and secondary Signs and symptoms of primary and secondary Increased aldosterone and cortisol to hypertension – Hypernatremia from high aldosterone – Hypokalemia from high aldosterone – Signs for hypertension Headache Vomiting Sleep disorder Vertigo Hyperglycemia - from high cortisol In female patients high androgen leads to facial hair growth High androgen in female patient suppresses female sex hormones such as estrogen.
MSH is melanocyte stimulating hormone controls pigment cells. This causes patient to have hyperpigmentation only in primary Addison’s disease. THIS DOESN’T happen in secondary Addison’s. Treatment Replace all these three hormones and solve problem Remove tumor if problem Treat infection with antibiotic Deal with autoimmune Secondary Addison’s disease Exists in hypothalamus or anterior lobe of pituitary Autoimmune Destruction Leads to decreased ACTH and CRH which decreases all three hormones from adrenal cortex. There is no feedback since no increase or decreases in peripheral hormones so no hyperpigmentation in patient Treatment is to replace hormones Cushing’s syndrome increases in hormones from adrenal cortex Primary Patient has tumor in adrenal cortex which leads to over secretion of three hormones (peripheral hormones). Increased peripheral decreases central hormones ACTH and decreases CRH (corticotropin releasing hormone) Secondary Case is high level of ACTH or high level of CRH which lead to increase in three hormones. CRH increases ACTH which increases three hormones from adrenal cortex. Overproduction of adrenal cortex hormones in primary and secondary Signs and symptoms of primary and secondary Increased aldosterone and cortisol – to hypertension Hypernatremia – from high aldosterone Hypokalemia – from high aldosterone Signs for hypertension Headache Vomiting Sleep disorder Vertigo Hyperglycemia - from high cortisol In female patients high androgen leads to facial hair growth High androgen in female patient suppresses female sex hormones such as estrogen.
chapter-15b-endocrine-glands.docx