lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q5 Is Adults and Reduction in Plasma peak Primary Solucortef, Hydrocortisone, outcome: Clinical vasopressors, pressors, vasoconstrictor agents hemodynamic children (not vasopressor and delta cure as defined inotropes, vasoactive response to neonates) therapy cortisol post by primary author medications hydrocortisone requirement (or 250 µg ACTH of studies OR and critical (50 to 300 mg) equivalent Resolved CIRCI illness superior to 250µg measure) symptoms ACTH test for the Mortality diagnosis of Secondary CIRCI? outcomes: Tissue hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q6 Is Adults and Plasma level Plasma peak Primary outcome: Clinical corticotropin level children (not corticotropin and delta cure as defined superior to 250µg neonates) cortisol post by primary author ACTH test for the 250 µg ACTH of studies OR and critical diagnosis of Resolved CIRCI illness CIRCI? symptoms Mortality
lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q5 Is hemodynamic response to hydrocortisone (50 to 300 mg) superior to 250µg ACTH test for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Reduction in vasopressor therapy requirement (or equivalent measure) Plasma peak and delta cortisol post 250 µg ACTH Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality Secondary outcomes: Tissue hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Solucortef, vasopressors, pressors, inotropes, vasoactive medications Hydrocortisone, vasoconstrictor agents Q6 Is corticotropin level superior to 250µg ACTH test for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Plasma level corticotropin Plasma peak and delta cortisol post 250 µg ACTH Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality
CCM_45_12_2017_09_14_ANNANE_CCMED-D-17-01644_SDC1.docx