Bacterial Infections Morphology Disease Pathogenesis Clinical Manifestation Microscopic Macroscopic Neurosyphilis Happens during Meningovascular Meningovascular Neurosyphilis (Meninges) the tertiary syphilis Neurosyphilis Lymphocytes and Primarily involved the This occurs in Apathy Types plasma cells appeared meninges of the about 10% of Seizures Meningovascular at the peripheral to Base of the brain syphilitic patients General paresis with neurosyphilis blood vessels Subarachnoid who didn’t have dementia Paretic Heubner Arteritis space proper treatment Paretic Neurosyphilis neurosyphilis Marked endothelial Blood vessels It is caused by Insidious loss of mental Tabes dorsalis thickening, thickened spirochete and physical function Tunica Treponema Mood alteration Tunica adventitia Delusion of pallidum grandeur Paretic Neurosyphilis (Brain Parenchyma) Terminating with severe Loss of neurons with appeared dementia microglial (rod cells) Shrunken Dorsalis proliferation Firm Impaired joint position Gliosis Frontal lobe is sense Loss of Ependymal lining atrophic Locomotor ataxia with subependymal Leptomeninges is Loss of pain sensation gliosis thickened Charcot’s joint Granular ependymitis With or wihout Skin and joint hydrocephalus damage Tabes Dorsalis (Spinal Cord) Lightning pains Loss of deep tendon Loss of axons and myelin Pallor and atrophy of reflex sheath at the Dorsal the Dorsal Column Column
Bacterial Infections Disease Pathogenesis Morphology Clinical Manifestation Microscopic Macroscopic Neurosyphilis Types Meningovascular neurosyphilis Paretic neurosyphilis Tabes dorsalis Happens during the tertiary syphilis This occurs in about 10% of syphilitic patients who didn’t have proper treatment It is caused by spirochete Treponema pallidum Meningovascular Neurosyphilis (Meninges) Meningovascular Neurosyphilis Apathy Seizures General paresis with dementia Paretic Neurosyphilis Insidious loss of mental and physical function Mood alteration Delusion of grandeur Terminating with severe dementia Dorsalis Impaired joint position sense Locomotor ataxia Loss of pain sensation Charcot’s joint Skin and joint damage Lightning pains Loss of deep tendon reflex Lymphocytes and plasma cells appeared at the peripheral to blood vessels Heubner Arteritis Marked endothelial thickening, thickened Tunica Tunica adventitia Primarily involved the meninges of the Base of the brain Subarachnoid space Blood vessels Paretic Neurosyphilis (Brain Parenchyma) Loss of neurons with microglial (rod cells) proliferation Gliosis Loss of Ependymal lining with subependymal gliosis Granular ependymitis appeared Shrunken Firm Frontal lobe is atrophic Leptomeninges is thickened With or wihout hydrocephalus Tabes Dorsalis (Spinal Cord) Loss of axons and myelin sheath at the Dorsal Column Pallor and atrophy of the Dorsal Column
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