What three organs is Creatinine synthesized in? Kidneys Liver Pancreas True or False: Creatinine is present in all body True fluids and secretions. What is Creatinine a marker of? Glomerular Filtration Rate (GFR) What reaction is used in Creatinine? reaction The Jaffe reaction of Creatinine has a reaction Picrate ion with what? Creatinine analytical methods tend to lack Specificity what? Name two enzymes of Creatinine Creatininase creatinase What are four analytical methodology factors Hydroxide that are used in Creatinine? Wavelength Enzymatic methods (Fig. 21-1) Temperature “Concentration” What type of state is Urea? Azotemic state Urea is an underestimation of what? Glomerular filtration rate Urea is an outdated indicator of what function? Kidney What is a chemical method of Urea? Fearon reaction What is an enzymatic method of Urea based Preliminary hydrolysis of urea with urease on? What three types of Urea enzymatic methods Spectrophotometric approached is used? Dry Chemistry Systems Specificity What does a spectrophotometric approach Berthelot method and enzymatic consist of? What does the biochemistry and physiology of Urate pool Uric Acid focus on? Renal handling of uric acid A clinical significance of Uric Acid that Purine metabolism involves, 20-plus inherited disorders of what metabolism? Uric Acid is used as a measurement in Gout management of what? What does Uric Acid help determine on during Link to underlying conditions Hypouricemia? Other causes Name two analytical methodology of Uric Phosphotungstic acid (PTA) Acid? Uricase Which is more specific, PTA or Uricase? Uricase What does HPLC-based methods focus on Ion-exchange or reversed-phase during Uric Acid? What does reference values of Uric Acid Gout indicate? Purine-containing and purine-free diets What are Carbohydrates ? or ketone derivatives of •Aldehyde polyhydroxy (more than one -OH
What three organs is Creatinine synthesized in? Kidneys Liver Pancreas True or False: Creatinine is present in all body fluids and secretions. True What is Creatinine a marker of? Glomerular Filtration Rate (GFR) What reaction is used in Creatinine? reaction The Jaffe reaction of Creatinine has a reaction with what? Picrate ion Creatinine analytical methods tend to lack what? Specificity Name two enzymes of Creatinine Creatininase creatinase What are four analytical methodology factors that are used in Creatinine? Enzymatic methods (Fig. 21-1) Hydroxide Wavelength Temperature “Concentration” What type of state is Urea? Azotemic state Urea is an underestimation of what? Glomerular filtration rate Urea is an outdated indicator of what function? Kidney What is a chemical method of Urea? Fearon reaction What is an enzymatic method of Urea based on? Preliminary hydrolysis of urea with urease What three types of Urea enzymatic methods approached is used? Spectrophotometric Dry Chemistry Systems Specificity What does a spectrophotometric approach consist of? Berthelot method and enzymatic What does the biochemistry and physiology of Uric Acid focus on? Urate pool Renal handling of uric acid A clinical significance of Uric Acid that involves, 20-plus inherited disorders of what metabolism? Purine metabolism Uric Acid is used as a measurement in management of what? Gout What does Uric Acid help determine on during Hypouricemia? Link to underlying conditions Other causes Name two analytical methodology of Uric Acid? Phosphotungstic acid (PTA) Uricase Which is more specific, PTA or Uricase? Uricase What does HPLC-based methods focus on during Uric Acid? Ion-exchange or reversed-phase What does reference values of Uric Acid indicate? Gout Purine-containing and purine-free diets What are Carbohydrates ? •Aldehyde or ketone derivatives of polyhydroxy (more than one -OH
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