One of the early problems in immunology was trying to understand how an organism with a limited number of genes (for humans, about 20,500) could produce a million different B cell protein receptors and 10 million different T cell receptors! The answer resulted in a Nobel Prize and a stratling exception to the notion that all cells have exactly the same DNA. Use figure 43.13 (page 938) to explain the four steps producing genetically unique B cell receptors. Explain how the body develops self-tolerance in the immune system.
One of the early problems in immunology was trying to understand how an organism with a limited number of genes (for humans, about 20,500) could produce a million different B cell protein receptors and 10 million different T cell receptors! The answer resulted in a Nobel Prize and a stratling exception to the notion that all cells have exactly the same DNA. Use figure 43.13 (page 938) to explain the four steps producing genetically unique B cell receptors. Explain how the body develops self-tolerance in the immune system.
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