F (blue): Expert opinion, formal consensus on experience not research Recommended good practice based on clinical evidence experience of an expert group e.g. NICE good practice recommendation G (pink): The evidence is Systematic review with studies judged as G (pink):It is not possible Single poor quality cohort inconsistent and it is not significant weak/risk of bias (evidence of no to draw a conclusion on or case control study possible to draw a conclusion effect) or review of moderate quality effectiveness of the demonstrating negative but it tends towards no effect studies with inconsistent findings in favour intervention effect of no effect H (red): is some evidence Systematic review of moderate to poor H is evidence RCT with a high risk of bias suggesting that this intervention quality studies with majority favouring no from a single study or well conducted cohort or is ineffective but it is not effect suggesting that this case control study with a conclusive intervention is ineffective low risk of confounding, but it is not conclusive bias or chance, demonstrating no effect I (dark red): There is moderate Systematic review of moderate to good I (dark red):There is RCTs with a low risk of bias to good quality evidence that quality studies with majority in favour of moderate to good evidence demonstrating no effect this intervention is unlikely to be control/no effect from a single study that effective this intervention is unlikely to be effective J (purple): There is high quality NICE specifically recommends this J (purple):There is high RCT with a very low risk of evidence of ineffectiveness or a intervention should not be adopted or there quality evidence of bias demonstrating no specific recommendation that is high quality review level evidence from ineffectiveness from a effect these interventions should not meta-analysis of good quality studies that single study be introduced in the UK demonstrates no effect K (grey): Evidence about the Systematic review or NICE guidance which effectiveness of the intervention concludes that no reliable evidence of is lacking. effectiveness of ineffectiveness, is available
F (blue): Expert opinion, formal consensus on experience not research evidence Recommended good practice based on clinical experience of an expert group e.g. NICE good practice recommendation G (pink): The evidence is inconsistent and it is not possible to draw a conclusion but it tends towards no effect Systematic review with studies judged as significant weak/risk of bias (evidence of no effect) or review of moderate quality studies with inconsistent findings in favour of no effect G (pink):It is not possible to draw a conclusion on effectiveness of the intervention Single poor quality cohort or case control study demonstrating negative effect H (red): is some evidence suggesting that this intervention is ineffective but it is not conclusive Systematic review of moderate to poor quality studies with majority favouring no effect H is evidence from a single study suggesting that this intervention is ineffective but it is not conclusive RCT with a high risk of bias or well conducted cohort or case control study with a low risk of confounding, bias or chance, demonstrating no effect I (dark red): There is moderate to good quality evidence that this intervention is unlikely to be effective Systematic review of moderate to good quality studies with majority in favour of control/no effect I (dark red):There is moderate to good evidence from a single study that this intervention is unlikely to be effective RCTs with a low risk of bias demonstrating no effect J (purple): There is high quality evidence of ineffectiveness or a specific recommendation that these interventions should not be introduced in the UK NICE specifically recommends this intervention should not be adopted or there is high quality review level evidence from meta-analysis of good quality studies that demonstrates no effect J (purple):There is high quality evidence of ineffectiveness from a single study RCT with a very low risk of bias demonstrating no effect K (grey): Evidence about the effectiveness of the intervention is lacking. Systematic review or NICE guidance which concludes that no reliable evidence of effectiveness of ineffectiveness, is available
CDR%20Research%20Evidence%20Review%20SUID%20report%20FINAL%20091014.docx