28 4 500 = 20 0.5 = 144 0.176 = 38 μM, β —/— μM, β μM, β 852 29 Polymer 9 4.12 34 μM —/— —/— μM 30 2 0.22 = 111 —/— μM, β —/— —/— 545 31 67 0.45 = 100 33 0.05 = 105 μM, β —/— μM μM, β 2824 32 9 230 nM, = 409 106 —/— —/— —/— β 33 4 0.78 = 4000a 0.1 = 875 112 μM, β —/— —/— μM, β a value calculated with galactose as reference. β Table 3 3 Multivalent compounds targeted to LecB. values are calculated versus fucose β Comp. Val. ELLA ITC Ref. 1 0.47 167 αMeFuc μM 35 4 Test biofilm 80% inhibition at 200 116 μM 36 4 0.14 = 79 125 μM, β —/— 37 4 0.11 = 100 126 μM, β —/— 38 8 0.025 = 440 168 μM, β —/— 39 10 0.25 = 22 117 μM, β —/— 40 2 0.09 118 —/— μM 41 2 0.62 = 3 119 —/— μM, β
28 4 500 μM, β = 20 —/— 0.5 μM, β = 144 0.176 μM, β = 852 38 29 Polymer 9 μM —/— —/— 4.12 μM 34 30 2 —/— 0.22 μM, β = 545 —/— —/— 111 31 67 0.45 μM, β = 100 —/— 33 μM 0.05 μM, β = 2824 105 32 9 —/— —/— —/— 230 nM, β = 409 106 33 4 0.78 μM, β = 4000a —/— —/— 0.1 μM, β = 875 112 a β value calculated with galactose as reference. Table 3 3 Multivalent compounds targeted to LecB. β values are calculated versus fucose Comp. Val. ELLA ITC Ref. αMeFuc 1 0.47 μM 167 35 4 Test biofilm 80% inhibition at 200 μM 116 36 4 0.14 μM, β = 79 —/— 125 37 4 0.11 μM, β = 100 —/— 126 38 8 0.025 μM, β = 440 —/— 168 39 10 0.25 μM, β = 22 —/— 117 40 2 —/— 0.09 μM 118 41 2 —/— 0.62 μM, β = 3 119
Chem_Soc_Rev_2013_42_4709-4727.docx