TREATMENT PICO QUESTIONS Questions Population Intervention Comparator Outcomes Keywords MESH terms (experimental (reference exposure) exposure) Q1 Should Adults and children (not Intravenous or No treatment ICU, intensive Critical Care, Primary outcome care, adults, patients with neonates) oral or 1. Resolution (or children, Hormone, CIRCI be and critical illness with corticosteroids placebo improvement) of pediatrics, critical Adrenal treated with CIRCI (not topical) of manifestations illness, CIRCI, Insufficiency, CIRCI [shock; critical Pediatrics, sepsis respiratory failure; Adult, sepsis, MODS; etc.] OR ‘heterogeneous’ corticosteroid systemic sepsis clinical cure as defined insufficiency, inflammatory CAP/HCAP by primary author of sepsis, infection, response studies septic shock, syndrome, CAP SIRS, systemic respiratory distress 2. Mortality: hospital or response syndrome Community acquired 28 or 90 days] syndrome, CAP, (adult), wounds pneumonia HCAP, and injuries, Meningitis Secondary outcomes: pneumonia, shock, Effective meningitis, hydrocortisone Septic shock inflammatory response ARDS, ALI, acute [cytokines, CRP, etc.] lung injury, ARDS trauma, cardiac Duration of: arrest, shock, Trauma treatment, hypotension, cardiogenic Multiple trauma ICU stay, hospital stay shock, steroids, Head trauma corticosteroids, Medium-long-term dexamethasone, outcome: hydrocortisone, -Mortality, QoL, solucortef, functional capacity, solumedrol, PTSS, etc. prednisone, prednisolone, betamethasone,
TREATMENT PICO QUESTIONS Questions Population Intervention (experimental exposure) Comparator (reference exposure) Outcomes Keywords MESH terms Q1 Should patients with CIRCI be treated with Adults and children (not neonates) and critical illness with CIRCI sepsis ‘heterogeneous’ sepsis CAP/HCAP CAP Community acquired pneumonia Meningitis Septic shock ARDS Trauma Multiple trauma Head trauma Intravenous or oral corticosteroids (not topical) No treatment or placebo Primary outcome 1. Resolution (or improvement) of manifestations of CIRCI [shock; respiratory failure; MODS; etc.] OR clinical cure as defined by primary author of studies 2. Mortality: hospital or 28 or 90 days] Secondary outcomes: Effective response [cytokines, CRP, etc.] Duration of: treatment, ICU stay, hospital stay Medium-long-term outcome: -Mortality, QoL, functional capacity, PTSS, etc. ICU, intensive care, adults, children, pediatrics, critical illness, CIRCI, critical corticosteroid insufficiency, sepsis, infection, septic shock, SIRS, systemic inflammatory response syndrome, CAP, HCAP, pneumonia, meningitis, ARDS, ALI, acute lung injury, trauma, cardiac arrest, shock, hypotension, cardiogenic shock, steroids, corticosteroids, dexamethasone, hydrocortisone, solucortef, solumedrol, prednisone, prednisolone, betamethasone, Critical Care, Hormone, Adrenal Insufficiency, Pediatrics, Adult, sepsis, systemic inflammatory response syndrome, respiratory distress syndrome (adult), wounds and injuries, shock, hydrocortisone
CCM_45_12_2017_09_14_ANNANE_CCMED-D-17-01644_SDC1.docx