Control (14) 2.9 Kono 1977 [88] 1 group/fixed Normal (5) 20 ng/kg/min 2.2 – Lottermoser 2003 [93] 1 Healthy (9) 150-180 10 ng/kg/min 7.4 1973 [100] 3 groups/incremental Normal 12 g (5), 2 ng/kg/min until 20 mm HG 5.9 20mEq (5) (diastolic) increase Anephric 0.86 Kidney allograft 6.4 Mediskou 2011 [104] 2 groups/incremental Hyperprolactinemic women (20) 150 6 ng/kg/min 2.7 Healthy (20) Positive (graph) Menard 1991 [105] 1 group/incremental Normal men (6) Ad libitum 4 ng/kg/min 2.1 Mendelsohn 1972 [106] 2 Hypertensive (17) 100 100 ng/min 1.9 10 1.5 Normotensive (8) 100 1.8 10 1.3 Oelkers 1975 [118] 1 Normal (5) Sequence: Graphs – sustained, incremental Incremental to 12 ng/kg/min (6 h) DR increase sequence Sustained 2 ng/kg/min for 66 h 4.6 Incremental to 16 ng/kg/min (6 h) Enhanced DR Ozono 1996 [123] 2 groups/incremental Japanese subjects Graphs: Modulating eHTN (6) 250 3 ng/kg/min (high Na) Modest response 10 3 ng/kg/mL (low Na) Greatest response Nonmodulating eHTN (9) 250 3 ng/kg/min (high Na) Modest response 10 3 ng/kg/mL (low Na) Modest response Price 1999 [126] 3 Healthy control (25) 10 mmol 3 ng/kg/min 5.3 (low Na) Hypertension (137) 2.5 200 mmol Hypertension, type II diabetes 1.9 (high Na) (42)
Control (14) 2.9 Kono 1977 [88] 1 group/fixed Normal (5) – 20 ng/kg/min 2.2 Lottermoser 2003 [93] 1 Healthy (9) 150-180 10 ng/kg/min 7.4 1973 [100] 3 groups/incremental Normal Anephric Kidney allograft 12 g (5), 20mEq (5) 2 ng/kg/min until 20 mm HG (diastolic) increase 5.9 0.86 6.4 Mediskou 2011 [104] 2 groups/incremental Hyperprolactinemic women (20) Healthy (20) 150 6 ng/kg/min 2.7 Positive (graph) Menard 1991 [105] 1 group/incremental Normal men (6) Ad libitum 4 ng/kg/min 2.1 Mendelsohn 1972 [106] 2 Hypertensive (17) Normotensive (8) 100 10 100 10 100 ng/min 1.9 1.5 1.8 1.3 Oelkers 1975 [118] 1 sustained, incremental sequence Normal (5) – Sequence: Incremental to 12 ng/kg/min (6 h) Sustained 2 ng/kg/min for 66 h Incremental to 16 ng/kg/min (6 h) Graphs DR increase 4.6 Enhanced DR Ozono 1996 [123] 2 groups/incremental Japanese subjects Modulating eHTN (6) Nonmodulating eHTN (9) 250 10 250 10 3 ng/kg/min (high Na) 3 ng/kg/mL (low Na) 3 ng/kg/min (high Na) 3 ng/kg/mL (low Na) Graphs: Modest response Greatest response Modest response Modest response Price 1999 [126] 3 Healthy control (25) Hypertension (137) Hypertension, type II diabetes (42) 10 mmol (low Na) 200 mmol (high Na) 3 ng/kg/min 5.3 2.5 1.9
CCM_45_8_2017_03_09_BUSSE_CCMED-D-17-00321_SDC3.docx