of funding not melanoma presenting a Overall patients mentioned risk of metastatic PET-CT study one Hospital spread. Reference standard 72,9% bias size: 35 imaging, or 92,7% did not receive the August Exclusion: patient with a follow-up including 94,4% same reference standard 2006-April 2007 cardiac pace metal tumor markers 66,7% regardless of the index between tests devices in the body, (S100 and lactate test result unclear allergy to contrast dehydrogenase) (6 MRI of reference test of tests: unclear medium, restricted renal months) 82,6% unclear function, pregnancy, 97,6% unknown claustrophobia 98,3% 76,9% Patient characteristics given Lung PET-CT: Se 30,7%, Sp Prevalence of 100% disease (malignant MRI: Se 61,5%, Sp 100% lesions): 70/120 = 58% Bone PET-CT: Se 71,4%, Sp 100% MRI: Se 82,8%, Sp 100% Liver PET-CT: Se 50%, Sp 100% MRI: Se 100%, Sp 100% Lymph nodes PET-CT: Se 82,7%, Sp 100% MRI: Se 89,6%, Sp N/A Abbreviations: VIBE: Volumetric interpolated breath-hold examination, PET: positron emission tomography, PET-CT: PET/computed tomography, FDG: Fluorine-18-Fluorodeoxyglucose, WB-MRI: magnetic resonance imaging, NPV: negative predictive value; PPV: positive predictive value
of funding not mentioned one Hospital size: 35 August 2006-April 2007 between tests unclear of tests: unclear melanoma presenting a risk of metastatic spread. Exclusion: patient with a cardiac pace metal devices in the body, allergy to contrast medium, restricted renal function, pregnancy, claustrophobia Patient characteristics given Prevalence of disease (malignant lesions): 70/120 = 58% Reference standard imaging, or follow-up including tumor markers (S100 and lactate dehydrogenase) (6 months) Overall PET-CT 72,9% 92,7% 94,4% 66,7% MRI 82,6% 97,6% 98,3% 76,9% Lung PET-CT: Se 30,7%, Sp 100% MRI: Se 61,5%, Sp 100% Bone PET-CT: Se 71,4%, Sp 100% MRI: Se 82,8%, Sp 100% Liver PET-CT: Se 50%, Sp 100% MRI: Se 100%, Sp 100% Lymph nodes PET-CT: Se 82,7%, Sp 100% MRI: Se 89,6%, Sp N/A patients study bias did not receive the same reference standard regardless of the index test result of reference test unclear unknown Abbreviations: VIBE: Volumetric interpolated breath-hold examination, PET: positron emission tomography, PET-CT: PET/computed tomography, FDG: Fluorine-18-Fluorodeoxyglucose, WB-MRI: magnetic resonance imaging, NPV: negative predictive value; PPV: positive predictive value
CoCanCPG_evidence_table_PICO_1_def.doc.docx