How substantial are the undesirable anticipated effects? Large ○ Moderate ○ Small ○ Effects Trivial ● Undesirable Varies ○ Don't know ○ What is the overall certainty of the evidence of effects? See Appendix 1 Very low ○ Low ● Moderate ○ The relative importance or values of the main High ○ outcomes of interest: No included studies ○ evidence of Certainty
Undesirable Effects How substantial are the undesirable anticipated effects? ○ Large ○ Moderate ○ Small ● Trivial ○ Varies ○ Don't know Certainty of evidence What is the overall certainty of the evidence of effects? ○ Very low ● Low ○ Moderate ○ High ○ No included studies See Appendix 1 The relative importance or values of the main outcomes of interest:
CCM_46_9_2018_06_08_DEVLIN_CCMED-D-18-00069_SDC41.docx