II A randomised controlled A prospective cohort A prospective study cohort study III-1 A pseudo-randomised All or none All or none controlled trial(i.e. alternate allocation or some other method) III-2 A comparative study with Analysis of prognostic A retrospective concurrent controls: factors amongst persons cohort study Non-randomised, experimental in a single arm of a randomised controlled Cohort study Case-control study Interrupted time series with a control group III-3 A comparative study without A retrospective cohort A case-control concurrent controls: study study Historical control study Two or more single arm study Interrupted time series without a parallel control group IV Case series with either post-test Case series, or cohort A cross-sectional or pre-test/post-test outcomes study of persons at study or case series different stages of disease 3.2.1.7 Quality of relevant evidence The quality of relevant item of evidence must be assessed utilising a published, critical appraisal instrument that is appropriate for the type of evidence being considered. The instrument must include as a minimum an assessment of the following: characterisation of the ingredient/s study design/methods participant eligibility (inclusion/exclusion criteria) randomisation and blinding of participants (for Randomised Controlled Trials (RCT)) sample size justification/power calculations controlling for potential confounders
II A randomised controlled A prospective cohort study A prospective cohort study III-1 A pseudo-randomised controlled trial(i.e. alternate allocation or some other method) All or none All or none III-2 A comparative study with concurrent controls: Non-randomised, experimental Cohort study Case-control study Interrupted time series with a control group Analysis of prognostic factors amongst persons in a single arm of a randomised controlled A retrospective cohort study III-3 A comparative study without concurrent controls: Historical control study Two or more single arm study Interrupted time series without a parallel control group A retrospective cohort study A case-control study IV Case series with either post-test or pre-test/post-test outcomes Case series, or cohort study of persons at different stages of disease A cross-sectional study or case series 3.2.1.7 Quality of relevant evidence The quality of relevant item of evidence must be assessed utilising a published, critical appraisal instrument that is appropriate for the type of evidence being considered. The instrument must include as a minimum an assessment of the following: characterisation of the ingredient/s study design/methods participant eligibility (inclusion/exclusion criteria) randomisation and blinding of participants (for Randomised Controlled Trials (RCT)) sample size justification/power calculations controlling for potential confounders
consult-cm-evidence-listed-medicines-120827-a.docx