HPHR Opioid Interchangeable Commercially Dosing ADP Efficacy Abuse Deterrent Available Frequency Category Drug Product Strengths Kadian® (morphine 20 mg/0.8 mg ER capsules) Morphine ER 12 or 24 hour capsules (generic 30 mg/1.2 mg Kadian®) Embeda® Every 24 Morphine ER 24 hour (morphine sulfate hours or Category II ER/naltrexone every 12 capsules (generic 50 mg/2 mg capsule) hours Avinza®) Morphine ER tablet 60 mg/2.4 mg (generic MS Contin®) MS Contin® 80 mg/3.2 mg (morphine ER tablet) 20 mg 30 mg 40 mg Zohydro ER® Hysingla ER® 24 (hydrocodone ER (hydrocodone ER 60 mg Category II hours capsule) tablet) 80 mg 100 mg 120 mg 50 mg 100 mg Nucynta ER® No equivalent HPHR 12 (tapentadol ER Category II 150 mg opioid identified hours tablet) 200 mg 250 mg
HPHR Opioid Interchangeable Abuse Deterrent Drug Product Commercially Available Strengths Dosing Frequency ADP Efficacy Category Kadian® (morphine ER capsules) Embeda® (morphine sulfate ER/naltrexone capsule) 20 mg/0.8 mg Every 24 hours or every 12 hours Category II Morphine ER 12 or 24 hour capsules (generic Kadian®) 30 mg/1.2 mg Morphine ER 24 hour capsules (generic Avinza®) 50 mg/2 mg Morphine ER tablet (generic MS Contin®) 60 mg/2.4 mg MS Contin® (morphine ER tablet) 80 mg/3.2 mg Zohydro ER® (hydrocodone ER capsule) Hysingla ER® (hydrocodone ER tablet) 20 mg 24 hours Category II 30 mg 40 mg 60 mg 80 mg 100 mg 120 mg No equivalent HPHR opioid identified Nucynta ER® (tapentadol ER tablet) 50 mg 12 hours Category II 100 mg 150 mg 200 mg 250 mg
105cmr720-proposed-revision_0.docx