Table 4. Clinical trials of oral ketoconazole in the treatment of canine Malassezia dermatitis in dogs. Study Design Dose used Clinical outcome Adverse effects Comment LoE Bensignor RCT-UB (10 dogs 5 OR 10 mg/kg 7/20 complete In 10 mg/kg trial: Small group sizes; two KTZ 2 2001[425] per group) once response, rest vomiting [n=2], doses compared partial anorexia [n=1], apathy [n=1] Rosales et al. RCT-B (7 dogs 5-10 mg/kg 4/7 >50 % clinical Nil group sizes and 2 2005 [148] received KTZ) twice daily improvement concurrent cefalexin therapy limits interpretation. Compared with terbinafine. Bensignor RCT-B (10 dogs 10 mg/kg once 4/10 complete Nil Small group sizes; compared to 2 2006[424] received KTZ) response, 6/10 pulse ITZ partial Bensignor et al. RCT-B (10 dogs) 10 mg/kg once 83% Not specified Abstract publication only; 2 2012[421] daily improvement at compared to shampoo alone 6 wks or combined with KTZ Sickafoose et al. RCT-B (12 dogs 5-10 mg/kg once 7/12 >50 % 6/12 dogs: Concurrent cefalexin therapy 2 2010[384] received KTZ + daily clinical transient limits interpretation. cefalexin) improvement anorexia [n=2], vomiting [n=3], vomiting and soft stool [n=1] RCT-B, randomised controlled blinded; RCT-UB, randomised controlled unblinded . – –
Table 4. Clinical trials of oral ketoconazole in the treatment of canine Malassezia dermatitis in dogs. Study Design Dose used Clinical outcome Adverse effects Comment LoE Bensignor 2001[425] RCT-UB (10 dogs per group) 5 OR 10 mg/kg once 7/20 complete response, rest partial In 10 mg/kg vomiting [n=2], anorexia [n=1], apathy [n=1] Small group sizes; two KTZ doses compared 2 Rosales et al. 2005 [148] RCT-B (7 dogs received KTZ) 5-10 mg/kg twice daily 4/7 >50 % clinical improvement Nil group sizes and concurrent cefalexin therapy limits interpretation. Compared with terbinafine. 2 Bensignor 2006[424] RCT-B (10 dogs received KTZ) 10 mg/kg once 4/10 complete response, 6/10 partial Nil Small group sizes; compared to pulse ITZ 2 Bensignor et al. 2012[421] RCT-B (10 dogs) 10 mg/kg once daily 83% improvement at 6 wks Not specified Abstract publication only; compared to shampoo alone or combined with KTZ 2 Sickafoose et al. 2010[384] RCT-B (12 dogs received KTZ + cefalexin) 5-10 mg/kg once daily 7/12 >50 % clinical improvement 6/12 dogs: transient anorexia [n=2], vomiting [n=3], vomiting and soft stool [n=1] Concurrent cefalexin therapy limits interpretation. 2 RCT-B, randomised controlled – blinded; RCT-UB, randomised controlled – unblinded . trial:
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