if the cylinder is fitted with a minimum 5.3.5 Cylinders should be subject to an internal visual pressure retention when there is no inspection when signal indicating there is a positive they are new residual pressure, the correct functioning of the valve should be checked, and if the in connection with any hydrostatic pressure test or valve is shown not to function properly the equivalent test. cylinder should be sent to maintenance, After fitting of the valve, the valve should be maintained in if the cylinder is not fitted with a minimum a closed position to prevent any contamination from pressure retention valve, when there is no entering the cylinder. positive residual pressure the cylinder should be put aside for additional 5.3.6 Checks to be performed before filling should measures, to make sure it is not include: contaminated with water or other a to determine the residual pressure (>3 to 5 contaminants; additional measures could bar) to ensure that the cylinder is not emptied; consist of internal visual inspection followed by cleaning using a validated Cylinders with no residual pressure should be put method; for additional measures to make sure they are not contaminated with water or other a check to ensure that all previous batch contaminants. These could include cleaning with labels have been removed; validated methods or visual inspection as justified; a check that any damaged product labels have Assuring that all batch labels and other labels if been removed and replaced; damaged have been removed; a visual external inspection of each cylinder, visual external inspection of each valve and mobile cryogenic vessel and for dents, arc container for dents, arc burns, debris, other damage burns, debris, other damage and and contamination with oil or grease; Cylinders contamination with oil or grease; cleaning should be cleaned, tested and maintained in an should be done if necessary; appropriate manner; a check of each cylinder or mobile cryogenic a check of each cylinder or cryogenic vessel valve vessel outlet connection to determine that it is connection to determine that it is the proper type the proper type for the particular gas involved; for the particular medicinal gas involved;
if the cylinder is fitted with a minimum pressure retention when there is no signal indicating there is a positive residual pressure, the correct functioning of the valve should be checked, and if the valve is shown not to function properly the cylinder should be sent to maintenance, if the cylinder is not fitted with a minimum pressure retention valve, when there is no positive residual pressure the cylinder should be put aside for additional measures, to make sure it is not contaminated with water or other contaminants; additional measures could consist of internal visual inspection followed by cleaning using a validated method; a check to ensure that all previous batch labels have been removed; a check that any damaged product labels have been removed and replaced; a visual external inspection of each cylinder, mobile cryogenic vessel and for dents, arc burns, debris, other damage and contamination with oil or grease; cleaning should be done if necessary; a check of each cylinder or mobile cryogenic vessel outlet connection to determine that it is the proper type for the particular gas involved; 5.3.5 Cylinders should be subject to an internal visual inspection when they are new in connection with any hydrostatic pressure test or equivalent test. After fitting of the valve, the valve should be maintained in a closed position to prevent any contamination from entering the cylinder. 5.3.6 Checks to be performed before filling should include: a to determine the residual pressure (>3 to 5 bar) to ensure that the cylinder is not emptied; Cylinders with no residual pressure should be put for additional measures to make sure they are not contaminated with water or other contaminants. These could include cleaning with validated methods or visual inspection as justified; Assuring that all batch labels and other labels if damaged have been removed; visual external inspection of each valve and container for dents, arc burns, debris, other damage and contamination with oil or grease; Cylinders should be cleaned, tested and maintained in an appropriate manner; a check of each cylinder or cryogenic vessel valve connection to determine that it is the proper type for the particular medicinal gas involved;
consult-manuf-automatic-adoption-pics-130529-comparison.docx