() Historical III-3 1,069 Aim: To investigate how the introduction of In multivariable analysis, first trimester control cfDNA testing influenced women's testing screening, nulliparity and working women choices following a positive Down syndrome were significant predictors of accepting screening. cfDNA, while only nulliparity was a predictor of declining IPD (OR = 0.61). Setting: Hong Kong Population: (largely Chinese) with a singleton pregnancy and a positive trisomy 21 screening (first trimester combined screen or second trimester screening depending on gestational age at presentation). Methods: With the use of descriptive statistics and a test, rates of women choosing the χ2 invasive test and those who declined further testing were compared before and after the introduction of cfDNA. We also compared demographic factors with rates of different options including an invasive test, cfDNA or further testing’. Predictors of ‘declined accepting cfDNA and an invasive test were analyzed with multiple logistic regression. Conventional screening was funded publicly, but cfDNA was not. Outcomes: differences in the uptake of invasive prenatal diagnosis (IPD) or no testing before and after the introduction of cfDNA and factors affecting choices.
() Historical control III-3 1,069 Aim: To investigate how the introduction of cfDNA testing influenced women's testing choices following a positive Down syndrome screening. Setting: Hong Kong Population: (largely Chinese) with a singleton pregnancy and a positive trisomy 21 screening (first trimester combined screen or second trimester screening depending on gestational age at presentation). Methods: With the use of descriptive statistics and a χ2 test, rates of women choosing the invasive test and those who declined further testing were compared before and after the introduction of cfDNA. We also compared demographic factors with rates of different options including an invasive test, cfDNA or ‘declined further testing’. Predictors of accepting cfDNA and an invasive test were analyzed with multiple logistic regression. Conventional screening was funded publicly, but cfDNA was not. Outcomes: differences in the uptake of invasive prenatal diagnosis (IPD) or no testing before and after the introduction of cfDNA and factors affecting choices. In multivariable analysis, first trimester screening, nulliparity and working women were significant predictors of accepting cfDNA, while only nulliparity was a predictor of declining IPD (OR = 0.61).
cfDNA%20testing%20evidence%20evaluation%2016May17.docx