Table 7. Clinical trials of a 2% miconazole / 2% chlorhexidine and 3% chlorhexidine shampoos in the treatment of canine Malassezia dermatitis. Study Product Design Frequency Clinical outcome Adverse effects Comment LoE Bond et al. 2% miconazole / RCT-B (16 basset Every third day 15/16 Nil Compared to 1 ‘marked 1995[147] 2% chlorhexidine hounds received improvement’ 0.25% selenium MC-CH) sulphide shampoo Maynard et al. 2% miconazole / RCT-B (32 dogs Twice weekly Good (≥50%) Nil Compared to 3% 1 2011[274] 2% chlorhexidine received MC-CH) response in 91% Chlorhexidine of dogs shampoo Bensignor et al. 2% miconazole / RCT-B (10 dogs) weekly 85% NR Abstract 2 2012[421] 2% chlorhexidine improvement at publication only 6 wks Maynard et al. 3% chlorhexidine RCT-B (22 dogs Thrice weekly for Good (≥50%) Transient Compared to 2% 1 2011 received CH) 2 weeks, then response in 86% miconazole / 2% twice weekly for of dogs pododermatitis chlorhexidine two weeks, then [n=1], increased weekly if needed pruritus [n=2], exfoliation [n=2]
Table 7. Clinical trials of a 2% miconazole / 2% chlorhexidine and 3% chlorhexidine shampoos in the treatment of canine Malassezia dermatitis. Study Product Design Frequency Clinical outcome Adverse effects Comment LoE Bond et al. 1995[147] 2% miconazole / 2% chlorhexidine RCT-B (16 basset hounds received MC-CH) Every third day 15/16 ‘marked improvement’ Nil Compared to 0.25% selenium sulphide shampoo 1 Maynard et al. 2011[274] 2% miconazole / 2% chlorhexidine RCT-B (32 dogs received MC-CH) Twice weekly Good (≥50%) response in 91% of dogs Nil Compared to 3% Chlorhexidine shampoo 1 Bensignor et al. 2012[421] 2% miconazole / 2% chlorhexidine RCT-B (10 dogs) weekly 85% improvement at 6 wks NR Abstract publication only 2 Maynard et al. 2011 3% chlorhexidine RCT-B (22 dogs received CH) Thrice weekly for 2 weeks, then twice weekly for two weeks, then weekly if needed Good (≥50%) response in 86% of dogs Transient pododermatitis [n=1], increased pruritus [n=2], exfoliation [n=2] Compared to 2% miconazole / 2% chlorhexidine 1
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