Others: Tissue fludrocortisone, cortivasol, hypoperfusion fluorinef, (measures with lactate mineralocorticoid, level or scoring glucocorticoid systems) adrenal hormones Harms: Any treatments harms Q2 Are Adults and children (not Prednisone Primary outcome synthetic neonates) Prednisolone 1. Resolution (or and critical illness with improvement) of acute superior to CIRCI (as defined by of manifestations original studies’ Betamethasone CIRCI [shock; for the authors) Dexamethasone respiratory failure; treatment of Fludrocortisone MODS; etc.] OR CIRCI? sepsis Hydrocortisone + clinical cure as defined fludrocortisone by primary author of ‘heterogeneous’ Cortivasol studies Septic 2. Mortality hospital or ARDS 28 or 90 days] Trauma Secondary outcomes: Multiple trauma Effective Head trauma response [cytokines, CRP, etc.] Duration of: treatment, ICU stay, hospital stay Medium-long-term outcome: -Mortality, QoL, functional capacity, PTSS, etc.
Others: Tissue hypoperfusion (measures with lactate level or scoring systems) Harms: Any treatments harms fludrocortisone, cortivasol, fluorinef, mineralocorticoid, glucocorticoid adrenal hormones Q2 Are synthetic superior to for the treatment of CIRCI? Adults and children (not neonates) and critical illness with CIRCI (as defined by original studies’ authors) sepsis ‘heterogeneous’ Septic ARDS Trauma Multiple trauma Head trauma Prednisone Prednisolone Betamethasone Dexamethasone Fludrocortisone Hydrocortisone + fludrocortisone Cortivasol Primary outcome 1. Resolution (or improvement) of acute manifestations of CIRCI [shock; respiratory failure; MODS; etc.] OR clinical cure as defined by primary author of studies 2. Mortality hospital or 28 or 90 days] Secondary outcomes: Effective response [cytokines, CRP, etc.] Duration of: treatment, ICU stay, hospital stay Medium-long-term outcome: -Mortality, QoL, functional capacity, PTSS, etc.
CCM_45_12_2017_09_14_ANNANE_CCMED-D-17-01644_SDC1.docx