hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q3 Is salivary Adults and Salivary free Plasma Primary Salivary free cortisol free cortisol level children (not cortisol unstimulated, outcome: Clinical superior to neonates) peak and delta cure as defined plasma total and critical total cortisol by primary author cortisol level for illness level of studies OR the diagnosis of Resolved CIRCI CIRCI? symptoms Mortality Secondary outcomes: Tissue hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q4 Is 1 µg ACTH Adults and Plasma peak Plasma peak Primary ACTH Stimulation test, test superior to children (not and delta and delta Clinical ACTH Stim test, outcome: 250µg ACTH test neonates) cortisol post 1 cortisol post cure as defined cosyntropin stimulation for the diagnosis and critical µg ACTH 250 µg ACTH by primary author test, corticotrophin test; of CIRCI? illness of studies OR tetracosactide test, Resolved CIRCI Synacthen test symptoms Standard stimulation Mortality test; low dose Secondary stimulation test outcomes: Tissue hypoperfusion (measures with
hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Q3 Is salivary free cortisol level superior to plasma total cortisol level for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Salivary free cortisol Plasma unstimulated, peak and delta total cortisol level Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality Secondary outcomes: Tissue hypoperfusion (measures with lactate level or scoring systems) Multiorgan system failure Assessment Length of stay Salivary free cortisol Q4 Is 1 µg ACTH test superior to 250µg ACTH test for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Plasma peak and delta cortisol post 1 µg ACTH Plasma peak and delta cortisol post 250 µg ACTH Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality Secondary outcomes: Tissue hypoperfusion (measures with ACTH Stimulation test, ACTH Stim test, cosyntropin stimulation test, corticotrophin test; tetracosactide test, Synacthen test Standard stimulation test; low dose stimulation test
CCM_45_12_2017_09_14_ANNANE_CCMED-D-17-01644_SDC1.docx