Neonatal 0.81 (0.22, 2.96) 0.752 115 2.21 (0.76, 6.40) 0.148 56 0.24 Childhood -2.30 (-10.30, 5.70) p=0.575 81 -1.08 (-11.91, 9.76) p=0.846 43 0.86 History of spontaneous preterm No Yes birth Obstetric 0.99 (0.51, 1.92) 0.972 273 0.82 (0.58, 1.16) 0.254 903 0.62 1.22 (0.55, 2.71) 0.620 270 0.48 (0.29, 0.79) 886 0.053 Neonatal 0.0042 Childhood -1.11 (-5.96, 3.73) 0.653 201 -0.14 (-2.79, 2.52) 0.919 656 0.73 History of any preterm birth No Yes 1.06 (0.53, 2.12) 0.868 250 0.81 (0.58, 1.14) 0.225 946 0.50 Obstetric Neonatal 1.09 0.48, 2.45) 0.836 248 0.52 (0.32, 0.84) 0.0079 927 0.12 Childhood -0.91 (-5.92, 4.11) 0.724 187 -0.37 (-2.96, 2.23) 0.782 681 0.85 Logistic or linear mixed effects regression models predicting outcome from treatment, subgroup and the interaction of treatment with the subgroup variable, adjusting for previous pregnancy of at least 14 weeks and a random effect for centre. The estimated treatment effect is presented within each subgroup as odds ratio or expected mean difference, as appropriate.
Neonatal 0.81 (0.22, 2.96) 0.752 115 2.21 (0.76, 6.40) 0.148 56 0.24 Childhood -2.30 (-10.30, 5.70) p=0.575 81 -1.08 (-11.91, 9.76) p=0.846 43 0.86 History of spontaneous preterm birth No Yes Obstetric 0.99 (0.51, 1.92) 0.972 273 0.82 (0.58, 1.16) 0.254 903 0.62 Neonatal 1.22 (0.55, 2.71) 0.620 270 0.48 (0.29, 0.79) 0.0042 886 0.053 Childhood -1.11 (-5.96, 3.73) 0.653 201 -0.14 (-2.79, 2.52) 0.919 656 0.73 History of any preterm birth No Yes Obstetric 1.06 (0.53, 2.12) 0.868 250 0.81 (0.58, 1.14) 0.225 946 0.50 Neonatal 1.09 0.48, 2.45) 0.836 248 0.52 (0.32, 0.84) 0.0079 927 0.12 Childhood -0.91 (-5.92, 4.11) 0.724 187 -0.37 (-2.96, 2.23) 0.782 681 0.85 Logistic or linear mixed effects regression models predicting outcome from treatment, subgroup and the interaction of treatment with the subgroup variable, adjusting for previous pregnancy of at least 14 weeks and a random effect for centre. The estimated treatment effect is presented within each subgroup as odds ratio or expected mean difference, as appropriate.
Corrected_preprint_version_OPPTIMUM_clean.docx