Interventions A (dark This intervention NICE Recommended A (dark RCT with a very low risk of is supported by good quality intervention/systematic review, of mostly intervention is supported bias demonstrating positive evidence of its effectiveness good quality studies, with meta-analysis of by evidence of its effect majority of studies favouring intervention effectiveness from a good effect quality single study B (light green): This intervention Systematic review of moderate to good B (light green):This RCT with a low risk of bias is supported by moderate quality studies with majority, or intervention is supported demonstrating positive quality evidence of its analysis demonstrating positive effect. by evidence of its effect effectiveness NICE grade B recommendation. effectiveness from a moderate quality single study C (yellow): There is some Systematic review of moderate to poor C (yellow):There is some RCT with a high risk of bias evidence supporting the use of quality studies with majority, or meta - evidence from a poor or well conducted cohort or this intervention but it is not favouring intervention or quality single study case control study with a conclusive systematic review where studies may be of supporting the use of this low risk of confounding, good quality and showing effect but the intervention but it is not bias or chance, number of studies is too small to allow firm conclusive demonstrating positive conclusions to be drawn effect D (orange): The evidence is Systematic review with significant D (orange):It is not Single poor quality cohort inconsistent and it is not weakness and high risk of bias (positive possible to draw a or case control possible to draw a conclusion results) or review of moderate quality with conclusion on effectiveness demonstrating positive but there is some evidence of inconsistent findings in favour of the of the intervention effect effect intervention E (bright orange): There is good evidence to suggest that this intervention has Moderate to good quality systematic review of a sound theoretical basis or that work in this area is likely to have an impact observational or qualitative studies or single but this has not been demonstrated in trials (this would apply particularly to observational (except cohort or case control) or pilot or novel interventions) qualitative study which suggest that the intervention addresses a significant risk factor or determinant of the behaviour of interest
Interventions A (dark This intervention is supported by good quality evidence of its effectiveness NICE Recommended intervention/systematic review, of mostly good quality studies, with meta-analysis of majority of studies favouring intervention effect A (dark intervention is supported by evidence of its effectiveness from a good quality single study RCT with a very low risk of bias demonstrating positive effect B (light green): This intervention is supported by moderate quality evidence of its effectiveness Systematic review of moderate to good quality studies with majority, or demonstrating positive effect. NICE grade B recommendation. B (light green):This intervention is supported by evidence of its effectiveness from a moderate quality single study RCT with a low risk of bias demonstrating positive effect C (yellow): There is some evidence supporting the use of this intervention but it is not conclusive Systematic review of moderate to poor quality studies with majority, or meta - analysis favouring intervention or systematic review where studies may be of good quality and showing effect but the number of studies is too small to allow firm conclusions to be drawn C (yellow):There is some evidence from a poor quality single study supporting the use of this intervention but it is not conclusive RCT with a high risk of bias or well conducted cohort or case control study with a low risk of confounding, bias or chance, demonstrating positive effect D (orange): The evidence is inconsistent and it is not possible to draw a conclusion but there is some evidence of effect Systematic review with significant weakness and high risk of bias (positive results) or review of moderate quality with inconsistent findings in favour of the intervention D (orange):It is not possible to draw a conclusion on effectiveness of the intervention Single poor quality cohort or case control demonstrating positive effect E (bright orange): There is good evidence to suggest that this intervention has a sound theoretical basis or that work in this area is likely to have an impact but this has not been demonstrated in trials (this would apply particularly to pilot or novel interventions) Moderate to good quality systematic review of observational or qualitative studies or single observational (except cohort or case control) or qualitative study which suggest that the intervention addresses a significant risk factor or determinant of the behaviour of interest
CDR%20Research%20Evidence%20Review%20SUID%20report%20FINAL%20091014.docx