Supplemental Table 23. Studies on prediction models Method delirious Effect Study Assessment Number Predictors Exclusion Predictor Inclusion Outcome Type Quality Article Model (%) Estimate Design Delirium / IC Total of Age 1.04 APACHE II 1.06 Coma No Ref Drug induced 1.7 Miscellaneous 14.9 Combination 17.1 Persistent Coma Admission category Delirious Surgery Ref after admission Medical Prospective CAM-ICU 1.4 Auditory/visual Trauma ICU Delirium Incidence Cohort 911/3056 Mixed 8hrly LOS 3.1 impairment Neurosurgery ++ vd Boogaard (30%) ICU ICU>24hrs 4.0 Mentally disbaled Infection Logistic Regression 2012 [1] Multicenter Bedside 2.9 CNS disorder Metabolic acidosis 1.3 Compliance rate Use of morphine CAM-ICU <80% None Ref 0.01-7.1 mg 1.5 7.2-18.6 mg 1.1 >18.6 mg 1.7 Use of sedatives 4.0 Urea concentration 1.0 (mmol/L) 1.5 Urgent admission Internal validation: bootstrapping, temporal validation. External validation: 4 other Dutch Hospitals. Pooled results presented here. AUROC 0.85 (95% CI 0.82-0.87) Comments Predictors available within 24 hours of admission. Predictor Effect Estimate: OR is the natural logarithm of the logistic regression coefficients of the prediction model. No 95% CI given. ICU: Intensive Care unit, CAM-ICU: Confusion Assessment Method for use in the ICU, LOS: Length of stay, CNS: Central Nervous System, APACHE II: Acute Physiology and Chronic Health Evaluation II, AUROC: area under the receiver operating characteristic curve, hrly: hourly, hrs:hours, hr: hour, OR: odds ratio, CI: confidence interval
Supplemental Table 23. Studies on prediction models Article Study Design Number of delirious / Total (%) Type IC Method Delirium Assessment Inclusion Exclusion Predictors Predictor Effect Estimate Outcome Model Quality vd Boogaard 2012 [1] Prospective Cohort Multicenter 911/3056 (30%) Mixed ICU CAM-ICU 8hrly Bedside LOS ICU>24hrs Persistent Coma Delirious after admission Auditory/visual impairment Mentally disbaled CNS disorder Compliance rate CAM-ICU <80% Age APACHE II Coma No Drug induced Miscellaneous Combination Admission category Surgery Medical Trauma Neurosurgery Infection Metabolic acidosis Use of morphine None 0.01-7.1 mg 7.2-18.6 mg >18.6 mg Use of sedatives Urea concentration (mmol/L) Urgent admission 1.04 1.06 Ref 1.7 14.9 17.1 Ref 1.4 3.1 4.0 2.9 1.3 Ref 1.5 1.1 1.7 4.0 1.0 1.5 ICU Delirium Incidence Logistic Regression ++ Comments Internal validation: bootstrapping, temporal validation. External validation: 4 other Dutch Hospitals. Pooled results presented here. AUROC 0.85 (95% CI 0.82-0.87) Predictors available within 24 hours of admission. Predictor Effect Estimate: OR is the natural logarithm of the logistic regression coefficients of the prediction model. No 95% CI given. ICU: Intensive Care unit, CAM-ICU: Confusion Assessment Method for use in the ICU, LOS: Length of stay, CNS: Central Nervous System, APACHE II: Acute Physiology and Chronic Health Evaluation II, AUROC: area under the receiver operating characteristic curve, hrly: hourly, hrs:hours, hr: hour, OR: odds ratio, CI: confidence interval
CCM_46_9_2018_06_08_DEVLIN_CCMED-D-18-00069_SDC31.docx