Supplemental Digital Content 1 DIAGNOSIS PICO QUESTIONS CIRCI - Diagnosis Questions Population Diagnostic Comparator Outcomes Keywords MESH Headings test (reference exposure) Q1 Is total Adults and Plasma Peak Plasma Basal Primary ICU, intensive care, Critical Care, cortisol response children (not cortisol level cortisol level outcome: Clinical adults, children, Adrenocorticotropic to ACTH superior neonates) post ACTH cure as defined pediatrics, critical Hormone, Adrenal to random and critical by primary author illness, cortisol level, Insufficiency, plasma total illness Plasma Delta of studies OR plasma cortisol, ACTH, Pediatrics, Adult cortisol for the cortisol Resolved CIRCI corticotrophin, diagnosis of symptoms adrenocorticotrophic, CIRCI? Mortality adrenal hormones, delta Secondary cortisol, basal cortisol, outcomes: cosyntropin, CIRCI, Tissue critical illness-related hypoperfusion corticosteroid (measures with insufficiency lactate or scoring systems) Multiorgan system failure Assessment Length of stay Q2 Is plasma Adults and Plasma Plasma Primary Free cortisol, peak free cortisol level children (not unstimulated unstimulated, outcome: Clinical cortisol, delta free superior to neonates) free cortisol peak and delta cure as defined cortisol plasma total and critical level total cortisol by primary author cortisol level for illness level of studies OR the diagnosis of Plasma peak Resolved CIRCI CIRCI? free cortisol symptoms level Mortality Secondary Plasma delta outcomes: free cortisol Tissue
Supplemental Digital Content 1 DIAGNOSIS PICO QUESTIONS CIRCI - Diagnosis Questions Population Diagnostic test Comparator (reference exposure) Outcomes Keywords MESH Headings Q1 Is total cortisol response to ACTH superior to random plasma total cortisol for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Plasma Peak cortisol level post ACTH Plasma Delta cortisol Plasma Basal cortisol level Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality Secondary outcomes: Tissue hypoperfusion (measures with lactate or scoring systems) Multiorgan system failure Assessment Length of stay ICU, intensive care, adults, children, pediatrics, critical illness, cortisol level, plasma cortisol, ACTH, corticotrophin, adrenocorticotrophic, adrenal hormones, delta cortisol, basal cortisol, cosyntropin, CIRCI, critical illness-related corticosteroid insufficiency Critical Care, Adrenocorticotropic Hormone, Adrenal Insufficiency, Pediatrics, Adult Q2 Is plasma free cortisol level superior to plasma total cortisol level for the diagnosis of CIRCI? Adults and children (not neonates) and critical illness Plasma unstimulated free cortisol level Plasma peak free cortisol level Plasma delta free cortisol Plasma unstimulated, peak and delta total cortisol level Primary outcome: Clinical cure as defined by primary author of studies OR Resolved CIRCI symptoms Mortality Secondary outcomes: Tissue Free cortisol, peak cortisol, delta free cortisol
CCM_45_12_2017_09_14_ANNANE_CCMED-D-17-01644_SDC1.docx