ONLINE APPENDIX Supplementary Methods Pulse sequence parameters and CMR protocol Cine imaging used a balanced steady-state free precession (bSSFP) pulse sequence (echo time (TE)/repetition time (TR)/flip angle 1.3ms/2.6ms/40°, spatial resolution 1.6×2.0×10mm, typical temporal resolution 25ms). Tissue tagging used a spatial modulation of magnetization (SPAMM) pulse sequence (spatial resolution 1.5×1.5×10mm, tag separation 7mm, temporal resolution typical TR/TE/flip angle 5.9/3.5/10°). T2-weighted ≤35ms, imaging used a dark-blood T2w fast spin echo short tau inversion-recovery (STIR) sequence (TE 90 ms, TR two R-R intervals, flip angle 90 degrees, spatial resolution 1.7×1.7×10 mm) and constant level appearance (CLEAR) homogeneity correction. T1 mapping used a 17-heart MOLLI method to acquire 11 images (3-3-5 acquisition with 3x R-R interval recovery epochs) in a single end-expiratory breath hold (1,2) (bSSFP readout in end-diastole, manual RF shim adjustments, 2x sensitivity-encoded (SENSE) acceleration, acquired spatial resolution 1.7×2.1×10mm, typical TE/TR/flip angle 2.7/1.06/35°). 0.1mmol/kg gadolinium-DTPA (gadopentetate dimeglumine; Magnevist, Bayer, Berlin, Germany) was then administered using a power injector (Spectris, Solaris, PA). Repeat MOLLI T1 mapping was performed at 15 minutes post-contrast, and LGE imaging at 16-20 minutes post contrast (inversion recovery-prepared T1-weighted gradient echo, inversion time according to Look-Locker scout, spatial resolution 1.54×1.75×10mm, TR/TE/flip angle 3.7/2.0/25°). In addition to the three LGE short-axis slices for analysis, a contiguous stack of LGE images was acquired immediately after the three slice LGE acquisition (imaging parameters as above, slice thickness 10mm, no slice gap).
ONLINE APPENDIX Supplementary Methods Pulse sequence parameters and CMR protocol Cine imaging used a balanced steady-state free precession (bSSFP) pulse sequence (echo time (TE)/repetition time (TR)/flip angle 1.3ms/2.6ms/40°, spatial resolution 1.6×2.0×10mm, typical temporal resolution 25ms). Tissue tagging used a spatial modulation of magnetization (SPAMM) pulse sequence (spatial resolution 1.5×1.5×10mm, tag separation 7mm, temporal resolution ≤35ms, typical TR/TE/flip angle 5.9/3.5/10°). T2-weighted imaging used a dark-blood T2w fast spin echo short tau inversion-recovery (STIR) sequence (TE 90 ms, TR two R-R intervals, flip angle 90 degrees, spatial resolution 1.7×1.7×10 mm) and constant level appearance (CLEAR) homogeneity correction. T1 mapping used a 17-heart MOLLI method to acquire 11 images (3-3-5 acquisition with 3x R-R interval recovery epochs) in a single end-expiratory breath hold (1,2) (bSSFP readout in end-diastole, manual RF shim adjustments, 2x sensitivity-encoded (SENSE) acceleration, acquired spatial resolution 1.7×2.1×10mm, typical TE/TR/flip angle 2.7/1.06/35°). 0.1mmol/kg gadolinium-DTPA (gadopentetate dimeglumine; Magnevist, Bayer, Berlin, Germany) was then administered using a power injector (Spectris, Solaris, PA). Repeat MOLLI T1 mapping was performed at 15 minutes post-contrast, and LGE imaging at 16-20 minutes post contrast (inversion recovery-prepared T1-weighted gradient echo, inversion time according to Look-Locker scout, spatial resolution 1.54×1.75×10mm, TR/TE/flip angle 3.7/2.0/25°). In addition to the three LGE short-axis slices for analysis, a contiguous stack of LGE images was acquired immediately after the three slice LGE acquisition (imaging parameters as above, slice thickness 10mm, no slice gap).
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