R.E.Schrimer, Modern methods of Pharmaceutical Analysis CRC Press. J.W.Robinson, Undergraduate Instrumental analysis. Marcel Dekker, Inc., New York Chromatography, D.R. Browning. Mcgraw Hill, London. Pharmaceutical Chemistry L.G. Chatten Ed., Marcel Dekker Inc., New York PHARMACEUTICS III – (Dosage formulations & design) PY . 4 . 103 Period/week: 4 Sessional : 30 Duration of Exam : 3 hrs Examination : 70 Nature of Exam : Theory UNIT I Dosage form necessities: Antioxidants, Preservatives, colouring, flavouring and – diluting agents, solvents and vehicles, their properties & selection. Surfactants, hydrocolloids, stabilizers. UNIT II Formulation: Importance, physical properties physical form particle size crystal – – – form. Bulk control solubility. Wet flow cohesiveness compressibility – – – organoleptic properties, chemical properties hydrolysis oxidation, racemization, – – polymerization, isomerization, and decarboxylations, enzymic decomposition; ( formulation excipients destabilizers, suspending and dispersing agents dyes – – – excipients.) UNIT III Stability of formulated products requirements, product stability, shelf life, – – overage, containers, closures. Kinetic principles and stability testing Reaction – rate and order, acid base catalysis, decomposition reactions, stabilization and – stability testing. UNIT IV Prolonged action pharmaceuticals benefits, limitations; oral products, – – terminology, drug elimination rate, types and construction of product, evaluation, parenteral products and evaluation.
R.E.Schrimer, Modern methods of Pharmaceutical Analysis CRC Press. J.W.Robinson, Undergraduate Instrumental analysis. Marcel Dekker, Inc., New York Chromatography, D.R. Browning. Mcgraw Hill, London. Pharmaceutical Chemistry L.G. Chatten Ed., Marcel Dekker Inc., New York PHARMACEUTICS – III (Dosage formulations & design) PY . 4 . 103 Period/week: 4 Sessional : 30 Duration of Exam : 3 hrs Examination : 70 Nature of Exam : Theory UNIT – I Dosage form necessities: Antioxidants, Preservatives, colouring, flavouring and diluting agents, solvents and vehicles, their properties & selection. Surfactants, hydrocolloids, stabilizers. UNIT – II Formulation: Importance, physical properties – physical form particle size – crystal form. Bulk control solubility. Wet flow – cohesiveness – compressibility – organoleptic properties, chemical properties – hydrolysis – oxidation, racemization, polymerization, isomerization, and decarboxylations, enzymic decomposition; ( formulation excipients – destabilizers, suspending and dispersing agents – dyes – excipients.) UNIT – III Stability of formulated products – requirements, product stability, shelf life, overage, containers, closures. Kinetic principles and stability testing – Reaction rate and order, acid – base catalysis, decomposition reactions, stabilization and stability testing. UNIT – IV Prolonged action pharmaceuticals – benefits, limitations; oral products, terminology, drug elimination rate, types and construction of product, evaluation, parenteral products and evaluation.
bpholdsyllabus.docx