- Density of nanomaterial: 10.5 g/cm3 (silver) Nanomaterial - Type of distribution: log-normal characterization - of nanomaterial: sphere - Solubility: non-soluble - Exposure pattern: single event Simulation - Simulation duration: 1 per day - Inhalation rate: 0.61 m3/hr - Species: human - Model: Yeh/Schum 5-lobe, Stochastic lung Airway morphometry - FRC: 3,300 mL - URT volume: 50 mL - Density: 10.5 g/cm3 Inhalation properties - Diamter: polydisperse mode (0.01-10 μm) MPPD - Constant exposure: acceleration of gravity (981.0 cm/s2), body orientation (upright), 82.0 for polydispersed mode), breathing μg/m3 Exposure conditions frequency (12 /min), tidal volume (833 mL), inspiratory fraction (0.5), breathing scenario (nasal) Deposition/clearance - Deposition only CEM, Consumer Exposure Model; ECETOC TRA, European Centre for Ecotoxicology and Toxicology of Chemicals Abbreviation: Targeted Risk Assessment; ACH, Air exchange rate; CMD, Count median diameter; MMD, Mass median diameter; MMAD, Mass median aerodynamic diameter; CV, Coefficient of variation; FRC, Functional residual capacity; URT, Upper respiratory tract; ICRP, International Commission on Radiological Protection.
Nanomaterial characterization - Density of nanomaterial: 10.5 g/cm3 (silver) - Type of distribution: log-normal - of nanomaterial: sphere - Solubility: non-soluble Simulation - Exposure pattern: single event - Simulation duration: 1 per day - Inhalation rate: 0.61 m3/hr MPPD Airway morphometry - Species: human - Model: Yeh/Schum 5-lobe, Stochastic lung - FRC: 3,300 mL - URT volume: 50 mL Inhalation properties - Density: 10.5 g/cm3 - Diamter: polydisperse mode (0.01-10 μm) Exposure conditions - Constant exposure: acceleration of gravity (981.0 cm/s2), body orientation (upright), 82.0 μg/m3 for polydispersed mode), breathing frequency (12 /min), tidal volume (833 mL), inspiratory fraction (0.5), breathing scenario (nasal) Deposition/clearance - Deposition only Abbreviation: CEM, Consumer Exposure Model; ECETOC TRA, European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment; ACH, Air exchange rate; CMD, Count median diameter; MMD, Mass median diameter; MMAD, Mass median aerodynamic diameter; CV, Coefficient of variation; FRC, Functional residual capacity; URT, Upper respiratory tract; ICRP, International Commission on Radiological Protection.
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