Wide cranial sutures Wormian bones stiffness Bulbous fingertips Mandible & clavicle hypoplasia Type B Mottled Acroosteolysis MAD <1 Almost all pigmentation IR/DM Progressive AR None contractures N N N N Dysmorphic facies year fat lost Skin atrophy glomerulopathy ↑TG Delayed closure of Alopecia cranial sutures SC calcifications Severe osteoporosis Skin atrophy Sinus Osteolysis Pigmented tachycardia Micrognathia 1-2 Almost all skin lesions Right bundle Growth failure Progeria AR None Scoliosis N N N N N years fat lost Alopecia branch block Short stature Syndrome Dental crowding Pulmonary (BANF1) Open cranial hypertension sutures joints AD Atypical Alopecia Small mandible Dysmorphic facies de Partial or Valvular IR/DM Mammary Progeria None Mottled skin Dental crowding N N Aged appearance generalized calcification hypoplasia ↑TG (LMNA) pigment High arched palate Short stature fat loss
Wide cranial sutures Wormian bones stiffness Bulbous fingertips Type B MAD AR <1 year Almost all fat lost None Mottled pigmentation Skin atrophy Alopecia Mandible & clavicle hypoplasia Acroosteolysis contractures Delayed closure of cranial sutures SC calcifications N IR/DM ↑TG N N N Progressive glomerulopathy Dysmorphic facies Progeria Syndrome (BANF1) AR 1-2 years Almost all fat lost None Skin atrophy Pigmented skin lesions Alopecia Severe osteoporosis Osteolysis Micrognathia Scoliosis Dental crowding Open cranial sutures joints Sinus tachycardia Right bundle branch block Pulmonary hypertension N N N N N Growth failure Short stature Atypical Progeria (LMNA) AD de Partial or generalized fat loss None Alopecia Mottled skin pigment Small mandible Dental crowding High arched palate Valvular calcification IR/DM ↑TG N N Mammary hypoplasia Dysmorphic facies Aged appearance Short stature
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