++ 100 ++/+++ 100 ++/+++ 100 1200 0 ++/+++ 100 ++ 100 ++/+++ 100 NIR +++ 1200 100 +++ 100 +++ 100 disintegration) 0 +/++ 100 + 100 + 100 - 1200 +/++ 100 + 100 + 100 0 ++ 100 ++ 100 +/++ 100 Photofrin 25 red ++ 100 ++ 100 ++ 100 1200 0 ++ 100 ++ 100 +/++ 100 blue 1200 ++ 100 ++ 100 ++ 100 b) GST MDR1 MRP7 Electric Concentration field Drug Irradiation [μM] intensity positive positive cells positive cells [V/cm] intensity intensity intensity [%] [%] [%] 0 - 0 ++ 100 ++ 100 - - - 1200 -/+ 100 ++ 100 ++ 90 0 + 100 +/++ 100 ++ 100 - 1200 ++ 100 ++ 100 ++ 77 2 + 100 +/++ 100 +/++ 100 0 NIR 1200 ++ 100 ++ 100 +/++ 100 0 ++/+++ 100 +/++ 100 +/++ 100 IR-775 - 1200 +++ 100 ++/+++ 100 ++/+++ 100 +++ (cell 8 0 ++ 100 +/++ 100 100 disintegration) NIR +++ (cell +++ (cell +++ (cell 1200 100 100 100 disintegration) disintegration) disintegration)
1200 ++ 100 ++/+++ 100 ++/+++ 100 NIR 0 ++/+++ 100 ++ 100 ++/+++ 100 1200 +++ disintegration) 100 +++ 100 +++ 100 Photofrin 25 - 0 +/++ 100 + 100 + 100 1200 +/++ 100 + 100 + 100 red 0 ++ 100 ++ 100 +/++ 100 1200 ++ 100 ++ 100 ++ 100 blue 0 ++ 100 ++ 100 +/++ 100 1200 ++ 100 ++ 100 ++ 100 b) Drug Concentration [μM] Irradiation Electric field intensity [V/cm] GST MDR1 MRP7 intensity positive [%] intensity positive cells [%] intensity positive cells [%] - - - 0 - 0 ++ 100 ++ 100 1200 -/+ 100 ++ 100 ++ 90 IR-775 2 - 0 + 100 +/++ 100 ++ 100 1200 ++ 100 ++ 100 ++ 77 NIR 0 + 100 +/++ 100 +/++ 100 1200 ++ 100 ++ 100 +/++ 100 8 - 0 ++/+++ 100 +/++ 100 +/++ 100 1200 +++ 100 ++/+++ 100 ++/+++ 100 NIR 0 ++ 100 +/++ 100 +++ (cell disintegration) 100 1200 +++ (cell disintegration) 100 +++ (cell disintegration) 100 +++ (cell disintegration) 100
1-s2.0-S1567539417306114-mmc1.docx