Familial Partial Lipodystrophy Subtype Onset Skin Muscle Meta-bolic Kidney Nervous GI GU Other ↓Fat ↑Fat Appendages Bone Liver Endocrine Mineral Spleen AN Child- Face Coronary Phlebomegaly IR/DM or Buttocks Neck Calf artery U Eruptive N N Hepatomegaly N Only ↑TG ♀ Abd hypertrophy disease xanthomata reported (sc + visc.) HTN Hirsutism PCOS AN Face Coronary IR/DM Pancreatitis Labial Phlebomegaly Muscle Proteinuria Nerve Buttocks Neck artery Hepatomegaly ↑TG AD Puberty Eruptive hypertrophy in late entrapment Lipomas (LMNA) Limbs Abd disease Mild Hepatic Breast hypoplasia xanthomata Myalgia stages syndromes (visc.) HTN steatosis Preeclampsia ↓Leptin Hirsutism Miscarriages IR/DM Trunk AN Hepatomegaly FPLD3 Muscular ↑TG AD Buttocks ±Abdomen Phlebomegaly HTN N N Hepatic PCOS (PPAR) appearance Mild Limbs Hirsutism steatosis ↓Leptin Child- Hepatomegaly Cushingoid FPLD4 Buttocks Muscle IR/DM AD or ±Face AN N N Hepatic PCOS appearance Limbs hypertrophy HTN ↑TG steatosis occasional FPLD5 Buttocks IR/DM Muscle Pancreatitis Diabetic AR Lower None AN Proteinuria N Irregular menses ↑TG hypertrophy HTN Hepatomegaly limbs ↓Leptin
Familial Partial Lipodystrophy Subtype Onset ↓Fat ↑Fat Skin Appendages Muscle Bone Mineral Meta-bolic Kidney Nervous GI Liver Spleen GU Endocrine Other U Child- or Buttocks Face Neck Abd (sc + visc.) AN Phlebomegaly Eruptive xanthomata Hirsutism Calf hypertrophy Coronary artery disease HTN IR/DM ↑TG N N Hepatomegaly N Only ♀ reported (LMNA) AD Puberty Buttocks Limbs Face Neck Abd (visc.) AN Phlebomegaly Eruptive xanthomata Hirsutism Muscle hypertrophy Myalgia Coronary artery disease HTN IR/DM ↑TG Mild ↓Leptin Proteinuria in late stages Nerve entrapment syndromes Pancreatitis Hepatomegaly Hepatic steatosis PCOS Labial Breast hypoplasia Preeclampsia Miscarriages Lipomas FPLD3 (PPAR) AD Trunk Buttocks Limbs ±Abdomen AN Phlebomegaly Hirsutism Muscular appearance HTN IR/DM ↑TG Mild ↓Leptin N N Hepatomegaly Hepatic steatosis PCOS FPLD4 AD Child- or Buttocks Limbs ±Face AN Muscle hypertrophy HTN IR/DM ↑TG N N Hepatomegaly Hepatic steatosis PCOS Cushingoid appearance occasional FPLD5 AR Buttocks Lower limbs None AN Muscle hypertrophy HTN IR/DM ↑TG ↓Leptin Proteinuria N Pancreatitis Hepatomegaly Irregular menses Diabetic
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