11 Advanced Adenoma This is the number of people diagnosed No agreed Approximately 19.3 detection rate with any advanced adenoma (villous or international per 1000 tubulovillous or, high grade dysplasia or, standard greater than or equal to 10 mm in size) per 1000 screened with a iFOBT result available for the first and subsequent screening round. 12 Adenoma detection This is the number of people diagnosed 13.3-22.3 per Approximately 34.7 rate with any adenoma per 1000 screened with 1000 (Range per 1000 a result available for the first and from population subsequent screening round. screening programmes with iFOBT) 13 Positive predictive This is the % of people with a malignant PPV Cancer first Approximately 4.5% value of FIT for cancer outcome in those having a colonoscopy screen for the first and subsequent screening round. 14 Positive predictive This is the % of people with any advanced No agreed Approximately of FIT for advanced adenoma in those having a colonoscopy international 36.0% adenoma for the first and subsequent screening standard round. 15 Positive predictive This is the % of people with any adenoma PPV adenoma of FIT for adenoma in those having a colonoscopy for the first Approximately 65.0% screen 9.6 40.3% – and subsequent screening round. * These timeframes have been extended by one week to allow adequate time for GPs to contact their patients who have a positive iFOBT result. ** This number was calculated on the expected number adverse event rates reported in the UK Bowel Cancer Screening Programme Quality Assurance Guidelines for Colonoscopy and based on the fact that 70 percent of Pilot participants proceeding to colonoscopy are identified to have had a lesion. Appendix 3: Revised participant bowel preparation information
11 Advanced Adenoma detection rate This is the number of people diagnosed with any advanced adenoma (villous or tubulovillous or, high grade dysplasia or, greater than or equal to 10 mm in size) per 1000 screened with a iFOBT result available for the first and subsequent screening round. No agreed international standard Approximately 19.3 per 1000 12 Adenoma detection rate This is the number of people diagnosed with any adenoma per 1000 screened with a result available for the first and subsequent screening round. 13.3-22.3 per 1000 (Range from population screening programmes with iFOBT) Approximately 34.7 per 1000 13 Positive predictive value of FIT for cancer This is the % of people with a malignant outcome in those having a colonoscopy for the first and subsequent screening round. PPV Cancer first screen Approximately 4.5% 14 Positive predictive of FIT for advanced adenoma This is the % of people with any advanced adenoma in those having a colonoscopy for the first and subsequent screening round. No agreed international standard Approximately 36.0% 15 Positive predictive of FIT for adenoma This is the % of people with any adenoma in those having a colonoscopy for the first and subsequent screening round. PPV adenoma screen 9.6 – 40.3% Approximately 65.0% * These timeframes have been extended by one week to allow adequate time for GPs to contact their patients who have a positive iFOBT result. ** This number was calculated on the expected number adverse event rates reported in the UK Bowel Cancer Screening Programme Quality Assurance Guidelines for Colonoscopy and based on the fact that 70 percent of Pilot participants proceeding to colonoscopy are identified to have had a lesion. Appendix 3: Revised participant bowel preparation information
bps-immersion-visit-report-150414.docx