Variable Reference Patient Outcome Result Quality Population of Evidence Positive Predictor Time Chaichana et al., 23 non-ambulatory Ambulation RR 2.9 Low patients recovery 45 non-ambulatory Ambulation 64 vs 18% Crnalic et al., patients recovery 20132 Furstenberg et 35 with neurologic ASIA 71 vs 29% <48 hours al., 20093 deficits improvement, 0 vs 29% deterioration Quraishi et al., 121 patients with Frankel 49 vs 36% neurologic deficits improvement, 7 vs 13% deterioration Hessler et al., 194 patients with Frankel >15 days -- OR 1, 3-5 3 & 10 20095 neurologic deficits days OR 7.6, 1-3 days days OR 10.2, <1 day OR 15.9 Furstenberg et 35 patients with ASIA 45 vs 0% Low Bladder Function al., 20093 neurologic deficits improvement, 0 vs 7% deterioration Park et al., 60 non-ambulatory Ambulation 86 vs 22% Low MRC ≥III 20136 patients recovery Putz et al. 35 patients with ASIA Improved - mean Very Low 20087 neurologic deficits Tokuhashi 9, No Tokuhashi change - mean Tokuhashi 8, Deteriorated - mean Negative Predictor Tokuhashi 7 Vertebral compression Chaichana et al., 35 non-ambulatory Ambulation 35 vs 50%* Very low 20098 patients recovery fracture Thoracic compression Chaichana et al., 23 non-ambulatory Ambulation RR 0.003** Low 20081 patients recovery fracture Chaichana et al., 23 non-ambulatory Ambulation RR 0.41 Low Preoperative RT 20081 patients recovery Prostate-specific factors Crnalic et al., Ambulation 64 vs 29% Low PSA ≥200 45 non-ambulatory 20132 recovery patients Crnalic et al., Ambulation 79 vs 46% Low 45 non-ambulatory 20132 recovery patients *p<0.09 **p<0.07
Variable Reference Patient Population Outcome Result Quality of Evidence Positive Predictor Time <48 hours Chaichana et al., 23 non-ambulatory patients Ambulation recovery RR 2.9 Low Crnalic et al., 20132 45 non-ambulatory patients Ambulation recovery 64 vs 18% Furstenberg et al., 20093 35 with neurologic deficits ASIA 71 vs 29% improvement, 0 vs 29% deterioration Quraishi et al., 121 patients with neurologic deficits Frankel 49 vs 36% improvement, 7 vs 13% deterioration 3 & 10 days Hessler et al., 20095 194 patients with neurologic deficits Frankel >15 days -- OR 1, 3-5 days OR 7.6, 1-3 days OR 10.2, <1 day OR 15.9 Bladder Function Furstenberg et al., 20093 35 patients with neurologic deficits ASIA 45 vs 0% improvement, 0 vs 7% deterioration Low MRC ≥III Park et al., 20136 60 non-ambulatory patients Ambulation recovery 86 vs 22% Low Tokuhashi Putz et al. 20087 35 patients with neurologic deficits ASIA Improved - mean Tokuhashi 9, No change - mean Tokuhashi 8, Deteriorated - mean Tokuhashi 7 Very Low Negative Predictor Vertebral compression fracture Chaichana et al., 20098 35 non-ambulatory patients Ambulation recovery 35 vs 50%* Very low Thoracic compression fracture Chaichana et al., 20081 23 non-ambulatory patients Ambulation recovery RR 0.003** Low Preoperative RT Chaichana et al., 20081 23 non-ambulatory patients Ambulation recovery RR 0.41 Low Prostate-specific factors PSA ≥200 Crnalic et al., 20132 45 non-ambulatory patients Ambulation recovery 64 vs 29% Low Crnalic et al., 20132 45 non-ambulatory patients Ambulation recovery 79 vs 46% Low *p<0.09 **p<0.07
BRS_2016_07_30_LAUFER_SPINE152748_SDC2.docx