X Chronic disease † § X Chronic lung disease Diabetes mellitus X CSF leaks X X Immunocompetent Cochlear implants X X persons Alcoholism X Chronic liver disease, X cirrhosis Cigarette smoking X Sickle cell disease/other X X X Persons with hemoglobinopathies functional or anatomic Congenital or acquired asplenia X X X asplenia Congenital or acquired X X X ¶ immunodeficiencies HIV infection X X X Chronic renal failure X X X Nephrotic syndrome X X X Leukemia X X X Immunocompromised Lymphoma X X X persons Hodgkin disease X X X Generalized malignancy X X X Iatrogenic X X X ** immunosuppression Solid organ transplant X X X Multiple myeloma X X X
Immunocompetent persons Chronic disease † X Chronic lung disease § X Diabetes mellitus X CSF leaks X X Cochlear implants X X Alcoholism X Chronic liver disease, cirrhosis X Cigarette smoking X Persons with functional or anatomic asplenia Sickle cell disease/other hemoglobinopathies X X X Congenital or acquired asplenia X X X Immunocompromised persons Congenital or acquired immunodeficiencies ¶ X X X HIV infection X X X Chronic renal failure X X X Nephrotic syndrome X X X Leukemia X X X Lymphoma X X X Hodgkin disease X X X Generalized malignancy X X X Iatrogenic immunosuppression ** X X X Solid organ transplant X X X Multiple myeloma X X X
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