Macrosomia Study ref Evidence Sample Setting/population Findings Comments Level size () II 2,358 Pregnant women (median Maternal deficit of 25(OH)D3 (<20 ng ml(-1)) was weeks of gestation 14.0, range associated with increased risk of fetal overweight 13.0-15.0) from the INMA defined as AC 90th percentile (OR=1.50, 95%CI: (INfancia y Medio Ambiente) 1.01-2.21; P=0.041) or as EFW 90th percentile (OR = cohort (Spain, 2003-2008) 1.47, 95% CI: 1.00-2.16; P = 0.046). No significant associations were found with rapid growth. Fetal anthropometry Study ref Evidence Sample Setting/population Findings Comments Level size () II 2,358 Pregnant women (median We found no association of maternal 25(OH)D3 weeks of gestation 14.0, range concentration with femur length and a weak 13.0-15.0) from the INMA inverse association with biparietal diameter at 34 (INfancia y Medio Ambiente) weeks. cohort (Spain, 2003-2008) Infant and childhood outcomes Growth in the first year Study ref Evidence Sample Setting/population Findings Comments Level size () II 3,730 Secondary analysis of data Neonates born to mothers with a deficient vitamin Deficient: derived from a large D status showed accelerated growth in weight ≤29.9 nmol/l ethnic cohort in The and length during the first year of life. Insufficient: Netherlands (Amsterdam Born 30-49.9 nmol/l Children and their Adequate: Development (ABCD) cohort), ≥50 nmol/l including women with singleton term deliveries.
Macrosomia Study ref Evidence Level Sample size Setting/population Findings Comments () II 2,358 Pregnant women (median weeks of gestation 14.0, range 13.0-15.0) from the INMA (INfancia y Medio Ambiente) cohort (Spain, 2003-2008) Maternal deficit of 25(OH)D3 (<20 ng ml(-1)) was associated with increased risk of fetal overweight defined as AC 90th percentile (OR=1.50, 95%CI: 1.01-2.21; P=0.041) or as EFW 90th percentile (OR = 1.47, 95% CI: 1.00-2.16; P = 0.046). No significant associations were found with rapid growth. Fetal anthropometry Study ref Evidence Level Sample size Setting/population Findings Comments () II 2,358 Pregnant women (median weeks of gestation 14.0, range 13.0-15.0) from the INMA (INfancia y Medio Ambiente) cohort (Spain, 2003-2008) We found no association of maternal 25(OH)D3 concentration with femur length and a weak inverse association with biparietal diameter at 34 weeks. Infant and childhood outcomes Growth in the first year Study ref Evidence Level Sample size Setting/population Findings Comments () II 3,730 Secondary analysis of data derived from a large cohort in The Netherlands (Amsterdam Born Children and their Development (ABCD) cohort), including women with singleton term deliveries. Neonates born to mothers with a deficient vitamin D status showed accelerated growth in weight and length during the first year of life. Deficient: ≤29.9 nmol/l Insufficient: 30-49.9 nmol/l Adequate: ≥50 nmol/l ethnic
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