(2010a). (w/w) mg/kg Mouse 0 C57BL/6♂ 0.005 ~ 100 125.8 TNF-α, in IgM & liver wt ↔ ↔ ↔ ↔ ↓ ↔ ↑ Diet ± 3.9 IFN-γ Spleen IFN-γ, IL-4 (centrilobular response 10d in liver hypertrophy) to LPS or Con A serum TGs & ↓ cholesterol serum ALP ↑ This study investigated the effect of PFOS & PFOA on hepatic immune status. Numbers of hepatic cells that appear immunophenotypically to be erythrocyte progenitors were increased, other intrahepatic immune cells were unaffected. There were decreased cytokines in the liver, but ex vivo production of IgM by hepatic B cells and IFN-γ by hepatic T cells with specific stimulators (LPS and Con A, respectively) was not statistically different from controls, but appeared to be larger in PFOS treated animals. Data for splenocytes not included. Study not suitable for NOEL determination. % diet µg/kg TAD (w/w) bw/d mg/kg 0 0 0.04 Qazi et al. ± (2010b). 0.002 Mouse B6C3F1♂ 11.6 bw serum with liver wt ↓ ↔ ↔ ↔ ↔ ↔ ↔ ↑ 0.000156 250 5.55 ± 0.2 gain IgM & IgG SRBC (also for
(2010a). Mouse C57BL/6♂ Diet 10d (w/w) mg/kg 0 0.005 ~ 100 125.8 ± 3.9 ↔ ↔ ↔ ↔ Spleen ↓ TNF-α, IFN-γ, IL-4 in liver ↔ in IgM & IFN-γ response to LPS or Con A ↑ liver wt (centrilobular hypertrophy) ↓ serum TGs & cholesterol ↑ serum ALP This study investigated the effect of PFOS & PFOA on hepatic immune status. Numbers of hepatic cells that appear immunophenotypically to be erythrocyte progenitors were increased, other intrahepatic immune cells were unaffected. There were decreased cytokines in the liver, but ex vivo production of IgM by hepatic B cells and IFN-γ by hepatic T cells with specific stimulators (LPS and Con A, respectively) was not statistically different from controls, but appeared to be larger in PFOS treated animals. Data for splenocytes not included. Study not suitable for NOEL determination. Qazi et al. (2010b). Mouse B6C3F1♂ % diet (w/w) µg/kg bw/d TAD mg/kg 0 0 0.04 ± 0.002 0.000156 250 5.55 11.6 ± 0.2 ↓ bw gain ↔ ↔ ↔ ↔ (also for ↔ serum IgM & IgG ↔ with SRBC ↑ liver wt
w8.-Immunomodulation-PFASs.docx