Supplementary 11. Top diseases and bio functions annotations derived from Ingenuity Pathway Analysis (IPA) Group Category value Number of molecules P Diseases and disorders 1.61E-02 1.13E-17 140 Neurological disease – Psychological disorders 8.90E-03 7.12E-06 69 – Hereditary disorder 1.51E-02 2.22E-05 51 – Organismal injury and abnormalities 1.61E-02 2.22E-05 358 – Skeletal and muscular disorders 1.60E-02 2.22E-05 88 – Molecular and cellular functions Cell cycle 1.57E-02 1.59E-05 60 – Cellular compromise 1.61E-02 1.59E-05 19 – Cellular development 1.51E-02 4.04E-05 163 – Cellular growth and proliferation 1.51E-02 4.87E-05 175 – Lipid metabolism 1.59E-02 1.07E-04 22 – Physiological system development and function Behavior 1.50E-02 1.57E-07 57 – 1.61E-02 1.57E-07 108 Nervous system development and function – Connective tissue development and function 1.23E-02 5.52E-07 69 – Skeletal and muscular system development and function 1.61E-02 5.52E-07 73 – Tissue morphology 1.50E-02 5.52E-07 112 –
Supplementary 11. Top diseases and bio functions annotations derived from Ingenuity Pathway Analysis (IPA) Group Category P value Number of molecules Diseases and disorders Neurological disease 1.61E-02 – 1.13E-17 140 Psychological disorders 8.90E-03 – 7.12E-06 69 Hereditary disorder 1.51E-02 – 2.22E-05 51 Organismal injury and abnormalities 1.61E-02 – 2.22E-05 358 Skeletal and muscular disorders 1.60E-02 – 2.22E-05 88 Molecular and cellular functions Cell cycle 1.57E-02 – 1.59E-05 60 Cellular compromise 1.61E-02 – 1.59E-05 19 Cellular development 1.51E-02 – 4.04E-05 163 Cellular growth and proliferation 1.51E-02 – 4.87E-05 175 Lipid metabolism 1.59E-02 – 1.07E-04 22 Physiological system development and function Behavior 1.50E-02 – 1.57E-07 57 Nervous system development and function 1.61E-02 – 1.57E-07 108 Connective tissue development and function 1.23E-02 – 5.52E-07 69 Skeletal and muscular system development and function 1.61E-02 – 5.52E-07 73 Tissue morphology 1.50E-02 – 5.52E-07 112
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