Transcription produces: codon 1 codon 2 codon 3 codon 4 codon 5 codon 6 Beginning of Sickle Cell Hemoglobin mRNA amino amino amino amino amino amino Translation produces: acid 1 acid 2 acid 3 acid 4 acid 5 acid 6 Beginning of Sickle Cell Hemoglobin Protein 26. Complete the above table. Use the table below to help with translation. mRNA codon ACU CAU CCU CUG GAG GUG Corresponding Thr His Pro Leu Glu Val (Threonine) (Histidine) (Proline) (Leucine) (Glutamic (Valine) amino acid acid) Compare the amino acid sequence for the beginning of sickle cell hemoglobin vs. the beginning 27. of normal hemoglobin. What difference do you observe? Sickle cell hemoglobin and normal hemoglobin differ in only a single amino acid out of more than 100 amino acids in the complete hemoglobin protein. This difference in a single amino acid results in the different properties of sickle cell hemoglobin compared to normal hemoglobin. Hemoglobin is carried inside red blood cells. Normal hemoglobin dissolves in the watery cytosol of red blood cells. Sickle cell hemoglobin tends to clump in long rods instead of dissolving in the cytosol. One reason why is: Valine (Val) is much less water-soluble than glutamic acid (Glu). acid 6 is in a crucial location on the outer surface of the hemoglobin protein. This shows how this difference between sickle cell hemoglobin and normal hemoglobin results in the symptoms of sickle cell anemia. Protein Phenotype (characteristics) Genotype Normal 2 copies of the allele hemoglobin Disk-shaped red blood cells can that codes for dissolves in squeeze through the small blood normal hemoglobin the cytosol of vessels (SS) red blood normal health cells. When sickle cell hemoglobin clumps 2 copies of the allele Sickle cell in long rods that codes for hemoglobin sickle-shaped red blood cells sickle cell hemoglobin can clump in block small blood vessels (ss) long rods reduced oxygen supply
Transcription produces: codon 1 codon 2 codon 3 codon 4 codon 5 codon 6 Beginning of Sickle Cell Hemoglobin mRNA Translation produces: amino acid 1 amino acid 2 amino acid 3 amino acid 4 amino acid 5 amino acid 6 Beginning of Sickle Cell Hemoglobin Protein 26. Complete the above table. Use the table below to help with translation. mRNA codon ACU CAU CCU CUG GAG GUG Corresponding amino acid Thr (Threonine) His (Histidine) Pro (Proline) Leu (Leucine) Glu (Glutamic acid) Val (Valine) 27. Compare the amino acid sequence for the beginning of sickle cell hemoglobin vs. the beginning of normal hemoglobin. What difference do you observe? Sickle cell hemoglobin and normal hemoglobin differ in only a single amino acid out of more than 100 amino acids in the complete hemoglobin protein. This difference in a single amino acid results in the different properties of sickle cell hemoglobin compared to normal hemoglobin. Hemoglobin is carried inside red blood cells. Normal hemoglobin dissolves in the watery cytosol of red blood cells. Sickle cell hemoglobin tends to clump in long rods instead of dissolving in the cytosol. One reason why is: Valine (Val) is much less water-soluble than glutamic acid (Glu). acid 6 is in a crucial location on the outer surface of the hemoglobin protein. This shows how this difference between sickle cell hemoglobin and normal hemoglobin results in the symptoms of sickle cell anemia. Genotype Protein Phenotype (characteristics) 2 copies of the allele that codes for normal hemoglobin (SS) Normal hemoglobin dissolves in the cytosol of red blood cells. Disk-shaped red blood cells can squeeze through the small blood vessels normal health 2 copies of the allele that codes for sickle cell hemoglobin (ss) Sickle cell hemoglobin can clump in long rods When sickle cell hemoglobin clumps in long rods sickle-shaped red blood cells block small blood vessels reduced oxygen supply
TranscriptionTranslationProtocol.docx