0.2±0.6 PSVT Verapamil (authors 2.9±5.7, speculate all 0.6±1.6 pts w/ AVRNT or ORT w/ Duration (min) concealed (diary, Holter) conduction. Digoxin 75±164, 47±157 Propranolol 60±112, 1±1 Verapamil 56±148, 1±1 Yeh SJ Effect of 15 Combination Direct Inducible PSVT N/A W/ placebo The heart rate N/A N/A Single dose of 1984 diltiazem diltiazem 120 comparison PSVT lasted was 87±16 (113) and on 2 AVRT (n=13) 164±89 min; 4 bpm before and 160 mg vs. consecutive d AVNRT (n=2) pts had 59±10 bpm at terminated as placebos spontaneous 90 min after acute PSVT conversion. diltiazem and propranolol Limited due to W/ diltiazem (p<0.001). EP study and efficacy and propranolol The systolic low numbers PSVT lasted and diastolic of AVNRT pts. 39±49 min pressures Not placebo (p<.001). 14 were, controlled. pts had respectively, spontaneous 111±11 and conversion in 77±10 mm an average of Hg before and 27 ±15 min. 88 + 9 and 66 + 9 mm Hg after None of the diltiazem and 14 pts had propranolol electrical (p<0.001) reinduction of sustained PSVT after conversion. Outpatient f/u w/ 50/51 conversion of PSVT w/in 21±16 min, f/u of 5.6 mo. Efficacy 71 Esmolol Placebo “SVT” (HR>120) VHD, AV block, Therapeutic Hypotension N/A p=NS Rapid onset
0.2±0.6 Verapamil 2.9±5.7, 0.6±1.6 Duration (min) (diary, Holter) Digoxin 75±164, 47±157 Propranolol 60±112, 1±1 Verapamil 56±148, 1±1 PSVT (authors speculate all pts w/ AVRNT or ORT w/ concealed conduction. Yeh SJ 1984 (113) Effect of diltiazem and as 15 Combination diltiazem 120 160 mg vs. placebos Direct comparison on 2 consecutive d Inducible PSVT AVRT (n=13) AVNRT (n=2) N/A W/ placebo PSVT lasted 164±89 min; 4 pts had spontaneous conversion. W/ diltiazem and propranolol PSVT lasted 39±49 min (p<.001). 14 pts had spontaneous conversion in an average of 27 ±15 min. None of the 14 pts had electrical reinduction of sustained PSVT after conversion. Outpatient f/u w/ 50/51 conversion of PSVT w/in 21±16 min, f/u of 5.6 mo. The heart rate was 87±16 bpm before and 59±10 bpm at 90 min after diltiazem and propranolol (p<0.001). The systolic and diastolic pressures were, respectively, 111±11 and 77±10 mm Hg before and 88 + 9 and 66 + 9 mm Hg after diltiazem and propranolol (p<0.001) N/A N/A Single dose of terminated acute PSVT Limited due to EP study efficacy and low numbers of AVNRT pts. Not placebo controlled. Efficacy 71 Esmolol Placebo “SVT” (HR>120) VHD, AV block, Therapeutic Hypotension N/A p=NS Rapid onset
2015_SVT_Evidence_Tables_Data_Supplement.docx