Febrile, Anti-leucocyte Up to several Unpleasant but Treat with Anti-pyretic (e.g. antibodies hours post not usually life Paracetamol 1g) transfusion threatening Initiate Safety Learning Event report (Datix) grade appropriately Urticaria IgE Antibodies in During Unpleasant but Treat or prevent with blood transfusion not usually life Antihistamine (Oral or IV) threatening Initiate Safety Learning Event report (Datix) grade appropriately Delayed Event Delayed IgG Antibodies 2 26 days post Not usually Poor response to transfusion – haemolytic to donor blood transfusion life Jaundice reaction threatening Send samples for investigation Review transfusion needs TA-GvHD Donor Extremely rare up to Usually None seen in the last 10 years (Transfusion lymphocytes 30 days following fatal following leucocyte depletion Associated transfusion Irradiated blood to risk’ ‘at Graft Versus groups Host Disease) Post Recipient 5 12 days post Rare but Contact Bloodbank to arrange – Transfusion antibodies transfusion treatable patient investigation at platelet Purpura (PTP) against HPA laboratory system Post Infected donor Post transfusion Rare Depends on virus Transfusion blood Seek specialist medical advice Infection Iron overload Occurs either with Rare but Use iron chelation therapy or single episode of treatable if venesection patients or long term diagnosed Monitor LFT’s and cardiac transfusion therapies enzymes Consider cardiac scans
Febrile, Anti-leucocyte antibodies Up to several hours post transfusion Unpleasant but not usually life threatening Treat with Anti-pyretic (e.g. Paracetamol 1g) Initiate Safety Learning Event report (Datix) grade appropriately Urticaria IgE Antibodies in blood During transfusion Unpleasant but not usually life threatening Treat or prevent with Antihistamine (Oral or IV) Initiate Safety Learning Event report (Datix) grade appropriately Delayed Event Delayed haemolytic reaction IgG Antibodies to donor blood 2 – 26 days post transfusion Not usually life threatening Poor response to transfusion Jaundice Send samples for investigation Review transfusion needs TA-GvHD (Transfusion Associated Graft Versus Host Disease) Donor lymphocytes Extremely rare up to 30 days following transfusion Usually fatal None seen in the last 10 years following leucocyte depletion Irradiated blood to ‘at risk’ groups Post Transfusion Purpura (PTP) Recipient antibodies against HPA system 5 – 12 days post transfusion Rare but treatable Contact Bloodbank to arrange patient investigation at platelet laboratory Post Transfusion Infection Infected donor blood Post transfusion Rare Depends on virus Seek specialist medical advice Iron overload patients Occurs either with single episode of or long term transfusion therapies Rare but treatable if diagnosed Use iron chelation therapy or venesection Monitor LFT’s and cardiac enzymes Consider cardiac scans
Transfusion%20Policy%20Adult.docx