() IV 1,550 Among pregnant women in a There was no association between early vitamin D Deficient:<50 maternity service that deficiency and preterm birth (p = 0.11). nmol/L (n=849 Australian recommends routine [55%]) study antenatal screening and Insufficient: 50-74 advises supplementation nmol/L (n=571 where necessary, Vitamin D [37%]) serum concentrations were Replete: >75nmol/L measured in early and late (n=130 [8%]) pregnancy. The relationship between initial vitamin D status, maternal factors and pregnancy outcomes were estimated. Small for gestational age Study ref Evidence Sample Setting/population Findings Comments Level size () II 280 Pregnant women at 11-13 Frequency of SGA neonates was similar in both Deficiency: weeks' gestation, of whom groups (5.3% – 25OHD <20 ng/ml and 3.9% – <20 ng/ml (54%) 75% used vitamin 25OHD>20 ng/ml). Insufficiency: supplementation. 20-30 ng/ml (34%) Sufficiency: >30ng/ml (11%) () II 3,730 Secondary analysis of data Compared with women with adequate vitamin D Deficient: derived from a large levels, women with deficient vitamin D levels had ≤29.9 nmol/l ethnic cohort in The a higher risk of SGA (OR 2.4, 95 % CI 1.9, 3.2). Insufficient: Netherlands (Amsterdam Born 30-49.9 nmol/l Children and their Adequate: Development (ABCD) cohort), ≥50 nmol/l including women with singleton term deliveries.
() IV Australian study 1,550 Among pregnant women in a maternity service that recommends routine antenatal screening and advises supplementation where necessary, Vitamin D serum concentrations were measured in early and late pregnancy. The relationship between initial vitamin D status, maternal factors and pregnancy outcomes were estimated. There was no association between early vitamin D deficiency and preterm birth (p = 0.11). Deficient:<50 nmol/L (n=849 [55%]) Insufficient: 50-74 nmol/L (n=571 [37%]) Replete: >75nmol/L (n=130 [8%]) Small for gestational age Study ref Evidence Level Sample size Setting/population Findings Comments () II 280 Pregnant women at 11-13 weeks' gestation, of whom 75% used vitamin supplementation. Frequency of SGA neonates was similar in both groups (5.3% – 25OHD <20 ng/ml and 3.9% – 25OHD>20 ng/ml). Deficiency: <20 ng/ml (54%) Insufficiency: 20-30 ng/ml (34%) Sufficiency: >30ng/ml (11%) () II 3,730 Secondary analysis of data derived from a large cohort in The Netherlands (Amsterdam Born Children and their Development (ABCD) cohort), including women with singleton term deliveries. Compared with women with adequate vitamin D levels, women with deficient vitamin D levels had a higher risk of SGA (OR 2.4, 95 % CI 1.9, 3.2). Deficient: ≤29.9 nmol/l Insufficient: 30-49.9 nmol/l Adequate: ≥50 nmol/l ethnic
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