Summary of bolt-on studies. Author Existing Added Methodology Tariff Results Advantages Disadvantages (date) tool Domain Method Brazier AQL-5D Pain Valuation study TTO No Addition of pain Use of patient data Potential focusing – significantly with both measures effect (2011) asthma and regression on co-efficients of (EQ-5D and Explored only an dimensions, but additive model specific analysis by dimension Results not and severity level. measure AQL-5D and When relating back AQL-6D were to the trial, the mean HS value produced applied to from the AQL-5D was consistently clinical trial data lower than for the AQL-6D across the 5 asthma symptom groups. Krabbe EQ-5D Cognition Comparison of VAS No 87 questionnaires Maintains Valuation (1999) EQ-5D+C paired health returned. 3 level university states, valued of the faculty members Cognitive using VAS. (they may place generated more emphasis systematically on values
Summary of bolt-on studies. Author (date) Existing tool Added Domain Methodology Method Tariff Results Advantages Disadvantages Brazier (2011) AQL-5D – asthma specific measure Pain Valuation study and regression analysis AQL-5D and AQL-6D were applied to clinical trial data TTO No Addition of pain significantly on co-efficients of dimensions, but by dimension and severity level. When relating back to the trial, the mean HS value produced from the AQL-5D was consistently lower than for the AQL-6D across the 5 asthma symptom groups. Use of patient data with both measures (EQ-5D and Potential focusing effect Explored only an additive model Results not Krabbe (1999) EQ-5D Cognition EQ-5D+C Comparison of paired health states, valued using VAS. VAS No 87 questionnaires returned. Cognitive generated systematically values Maintains 3 level of the Valuation university faculty members (they may place more emphasis on
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