1000–1200 IU versus 2000 IU per day Maternal and neonatal 25(OH)D Study ref Design LoE N Intervention/observation/comparison population Results Limitations () RCT II 226 Setting: Greater Vancouver Canada Fewer infants born to mothers in the 2000 IU/d Unclear risk of group had a 25(OH)D concentration bias; see Population: Healthy pregnant women aged <30nmol/L than infants in the 1000 IU/d and Section 2.7 y 400 IU/d groups, respectively (2% vs 16% and Intervention: 400 IU/d, 1000 IU/d or 2000 IU/d 43%; P < 0.05). vitamin D3/d from 13 to 24 wk of gestation until Fewer than 15% of infants in the 400 or 1000/d 8 wk postpartum, with no infant groups achieved a 25(OH)D concentration supplementation. Mother and infant blood was >75 nmol/L compared with 44% in the 2000 collected at 8 wk postpartum. IU/d group (P<0.05). Almost all infants (~98%, Outcome: prevalence of infant serum 25(OH)D n = 44) born to mothers in the 2000 IU/d group cutoffs (>30, >40, >50, and >75 nmol/L) by dose achieved a 25(OH)D concentration >30 at 8 wk of age. nmol/L. At 8 wk postpartum, mean maternal 25(OH)D concentration was higher in the 2000 IU/d [88 (84, 91)] than in the 1000 IU/d [78 (74, 81)] or 400 IU/d [69 (66, 73)] groups (P < 0.05).
1000–1200 IU versus 2000 IU per day Maternal and neonatal 25(OH)D Study ref Design LoE N Intervention/observation/comparison population Results Limitations () RCT II 226 Setting: Greater Vancouver Canada Population: Healthy pregnant women aged y Intervention: 400 IU/d, 1000 IU/d or 2000 IU/d vitamin D3/d from 13 to 24 wk of gestation until 8 wk postpartum, with no infant supplementation. Mother and infant blood was collected at 8 wk postpartum. Outcome: prevalence of infant serum 25(OH)D cutoffs (>30, >40, >50, and >75 nmol/L) by dose at 8 wk of age. Fewer infants born to mothers in the 2000 IU/d group had a 25(OH)D concentration <30nmol/L than infants in the 1000 IU/d and 400 IU/d groups, respectively (2% vs 16% and 43%; P < 0.05). Fewer than 15% of infants in the 400 or 1000/d groups achieved a 25(OH)D concentration >75 nmol/L compared with 44% in the 2000 IU/d group (P<0.05). Almost all infants (~98%, n = 44) born to mothers in the 2000 IU/d group achieved a 25(OH)D concentration >30 nmol/L. At 8 wk postpartum, mean maternal 25(OH)D concentration was higher in the 2000 IU/d [88 (84, 91)] than in the 1000 IU/d [78 (74, 81)] or 400 IU/d [69 (66, 73)] groups (P < 0.05). Unclear risk of bias; see Section 2.7
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