Neonatal serum calcium Study ref Design LoE N Intervention/observation/comparison population Results Limitations () SLR I 76 (11 RCTs; 65 observational studies) A modest positive relationship was identified Study studies between maternal 25(OH)D and offspring methodology cord blood or postnatal calcium varied widely concentrations in a meta-analysis of six in terms of intervention studies (all found to be at high study design, risk of bias; mean difference 0.05mmol/l, 95% population CI 0.02 to 0.05mmol/l). used, vitamin D status NB of studies not included in the Cochrane assessment, review, one compared vitamin D plus exposure calcium vs no supplement and found a measured significant difference in serum calcium in and outcome cord blood (p<0.25). definition.
Neonatal serum calcium Study ref Design LoE N Intervention/observation/comparison population Results Limitations () SLR I 76 studies (11 RCTs; 65 observational studies) A modest positive relationship was identified between maternal 25(OH)D and offspring cord blood or postnatal calcium concentrations in a meta-analysis of six intervention studies (all found to be at high risk of bias; mean difference 0.05mmol/l, 95% CI 0.02 to 0.05mmol/l). NB of studies not included in the Cochrane review, one compared vitamin D plus calcium vs no supplement and found a significant difference in serum calcium in cord blood (p<0.25). Study methodology varied widely in terms of study design, population used, vitamin D status assessment, exposure measured and outcome definition.
Vitamin%20D%20evidence%20evaluation%2022May17.docx