HCV antibody positive result may indicate past HCV infection. EASL 2016 recommend that positive, HCV RNA “Anti-HCV negative individuals should be retested for HCV RNA 3 months later to confirm definitive clearance”26. Reactive or RNA not Reactive or 4 No evidence of active HCV infection. Equivocal detected Equivocal Suggest a repeat sample to confirm HCV antibody status. Please note that undetectable HCV RNA does not exclude current infection because viraemia may be intermittent. Suggest testing a follow-up blood for HCV NAAT to investigate possible fluctuating viraemia49, 26. Consider reporting initial HCV Ab reactivity according to local Reactive or RNA not 5 Not reactive No evidence of active HCV infection. policy. Equivocal detected HCV RNA detected. Indicates either acute HCV infection or possibly a chronic infection in an immunocompromised patient. Evidence of active HCV infection. Please ensure hepatitis A and B vaccination status is known Advise referral to an appropriate and vaccination given if needed. 6 Not tested Not reactive RNA detected specialist for further assessment/treatment. Consider requesting HCV genotyping and other BBV testing unless already performed. Hepatitis A and B vaccine recommended if appropriate.
4 Reactive or Equivocal RNA not detected Reactive or Equivocal No evidence of active HCV infection. HCV antibody positive result may indicate past HCV infection. EASL 2016 recommend that “Anti-HCV positive, HCV RNA negative individuals should be retested for HCV RNA 3 months later to confirm definitive clearance”26. Suggest a repeat sample to confirm HCV antibody status. Please note that undetectable HCV RNA does not exclude current infection because viraemia may be intermittent. Suggest testing a follow-up blood for HCV NAAT to investigate possible fluctuating viraemia49, 26. 5 Reactive or Equivocal RNA not detected Not reactive No evidence of active HCV infection. Consider reporting initial HCV Ab reactivity according to local policy. 6 Not reactive RNA detected Not tested HCV RNA detected. Evidence of active HCV infection. Advise referral to an appropriate specialist for further assessment/treatment. Hepatitis A and B vaccine recommended if appropriate. Indicates either acute HCV infection or possibly a chronic infection in an immunocompromised patient. Please ensure hepatitis A and B vaccination status is known and vaccination given if needed. Consider requesting HCV genotyping and other BBV testing unless already performed.
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