between centres giving optimal conditions for decision tree analysis on which approaches are suitable for personalised medicine R5 Next Generation All centres have demonstrated successful WP2, WP3, WP4 Sequencing to work Next Generation Sequencing testing adequately on using formalin-fixed paraffin embedded paraffin embedded samples in their own laboratories. WES samples will use validated fresh frozen material. R6 Technology platforms not Logistic planning in preparatory phase in WP2, WP3, WP4 ready in time for sample order to harmonise sample delivery with analysis analysis capacities. R7 Schedule slippage, late Regular meetings with Prinicipal WP1 deliveries and slow Investigator and Secondment Host will progress in general identify problems early on. Relevant indicators will be defined to identify trends in progress achievement, showing the average actual schedule slippage of each task with respect to the original planning;
between centres giving optimal conditions for decision tree analysis on which approaches are suitable for personalised medicine R5 Next Generation Sequencing to work adequately on paraffin embedded samples All centres have demonstrated successful Next Generation Sequencing testing using formalin-fixed paraffin embedded samples in their own laboratories. WES will use validated fresh frozen material. WP2, WP3, WP4 R6 Technology platforms not ready in time for sample analysis Logistic planning in preparatory phase in order to harmonise sample delivery with analysis capacities. WP2, WP3, WP4 R7 Schedule slippage, late deliveries and slow progress in general Regular meetings with Prinicipal Investigator and Secondment Host will identify problems early on. Relevant indicators will be defined to identify trends in progress achievement, showing the average actual schedule slippage of each task with respect to the original planning; WP1
UCD%20TOPMed10%20Risk%20Assessment%20Template%20NOV15.docx