given 6 times in 24 hours, followed by 5 doses every four hours. The study abstract indicates that it was a double blind randomised crossover investigation of 26 patients with coxarthrosis and persistent pain. The analgesic efficacy of ibuprofen plus codeine was significantly superior to that of ibuprofen which was, in turn, superior to that of placebo. The Peloso study was placebo controlled and did not address the issue of incremental effectiveness. The Kjaersgaard-Andersen study looked at the incremental effectiveness of high dose (60mg) codeine and paracetamol. The Quiding study was included in the commissioned review. Neither the da Cochrane review, nor the individual studies mentioned above, provides evidence of the incremental analgesic
given 6 times in 24 hours, followed by 5 doses every four hours. The study abstract indicates that it was a double blind randomised crossover investigation of 26 patients with coxarthrosis and persistent pain. The analgesic efficacy of ibuprofen plus codeine was significantly superior to that of ibuprofen which was, in turn, superior to that of placebo. The Peloso study was placebo controlled and did not address the issue of incremental effectiveness. The Kjaersgaard-Andersen study looked at the incremental effectiveness of high dose (60mg) codeine and paracetamol. The Quiding study was included in the commissioned review. Neither the da Cochrane review, nor the individual studies mentioned above, provides evidence of the incremental analgesic
update-codeine-safety-and-efficacy-review.docx