Figure A3 Cumulative frequency distribution of Munro no observed effect levels (NOELs) and corresponding NHMRC and WHO NOELs for compounds with Australian and WHO drinking water guidelines A. 100 80 Munro Y = 11.615 Ln(x) + 37.995 (R2 = 0.9288) 60 ADWG/WHO 40 Y = 12.448 Ln(x) + 40.746 Munro data (R2 = 0.9570) (n=56) NHMRC/WHO 20 data (n=62) Regression equations: 0 0.001 0.01 0.1 1 10 100 1000 B. NOEL (mg/kg/day) 100 Regression equations: 80 Munro Y = 20.592 Ln(x) 10.71 – 60 (R2 = 0.6991) 3 40 ADWG/WHO Y = 15.636 Ln(x) + 8.3364 Munro data (n=6) (R2 = 0.9877) 20 NHMRC/WHO data (n=8) 0 0.001 0.01 0.1 1 10 100 1000 NOEL (mg/kg/day) C. 100 Y = 11.775 Ln(x) + 39.714 80 (R2 = 0.9153) ADWG/WHO 60 Munro data Y = 13.367 Ln(x) + 44.296 0.15 (R2 = 0.9434) (n=49) NHMRC/WHO 40 data (n=53) 20 Regression equations: Munro 0 0.001 0.01 0.1 1 10 100 1000 NOEL (mg/kg/day) ADWG = NHMRC = National Health and Medical Research Council; NOEL = no Australian Drinking Water Guidelines; observed effect level; WHO = World Health Organization a All compounds in Table 4.4 in common with Munro database. b Class I compounds (corresponding Munro database derived TTC value indicated by arrow).
Figure A3 Cumulative frequency distribution of Munro no observed effect levels (NOELs) and corresponding NHMRC and WHO NOELs for compounds with Australian and WHO drinking water guidelines A. 100 80 60 40 Munro data (n=56) 20 NHMRC/WHO data (n=62) Regression equations: Munro Y = 11.615 Ln(x) + 37.995 (R2 = 0.9288) ADWG/WHO Y = 12.448 Ln(x) + 40.746 (R2 = 0.9570) 0 0.001 0.01 0.1 1 10 100 1000 B. NOEL (mg/kg/day) 100 80 60 3 40 Munro data (n=6) 20 NHMRC/WHO data (n=8) 0 Regression equations: Munro Y = 20.592 Ln(x) – 10.71 (R2 = 0.6991) ADWG/WHO Y = 15.636 Ln(x) + 8.3364 (R2 = 0.9877) 0.001 0.01 0.1 1 10 100 1000 NOEL (mg/kg/day) C. 100 80 60 0.15 40 20 Munro data (n=49) NHMRC/WHO data (n=53) Regression equations: Munro Y = 11.775 Ln(x) + 39.714 (R2 = 0.9153) ADWG/WHO Y = 13.367 Ln(x) + 44.296 (R2 = 0.9434) 0 0.001 0.01 0.1 1 10 100 1000 NOEL (mg/kg/day) ADWG = Australian Drinking Water Guidelines; NHMRC = National Health and Medical Research Council; NOEL = no observed effect level; WHO = World Health Organization a All compounds in Table 4.4 in common with Munro database. b Class I compounds (corresponding Munro database derived TTC value indicated by arrow).
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