1.1 Determinants of vitamin D status in pregnancy Level II studies Study ref Evidence Sample Setting/population Findings Comments Level size () II 50 150 serum samples from BMI: Mean 250HD concentrations by BMI in 1st Optimal 250HD women in 1st, 2nd and 3rd trimester differed significantly (p<0.05): levels (30-80 ng/ml) trimester of pregnancy in 30.0% BMI <21 (13 patients, 39 samples): 27.3 ng/mL Warsaw. 72.7% of the sera Hypovitaminosis BMI >25 (14 patients, 42 samples): 23.5 ng/mL were from women who (20-30 ng/ml): reported taking multivitamin 38.7%, supplements containing Deficiency vitamin D3 (71% of that group (10-20 ng/ml): was taking 400 IU daily). 24.0% Severe deficiency (< 10 ng/ml) 7.3%
1.1 Determinants of vitamin D status in pregnancy Level II studies Study ref Evidence Level Sample size Setting/population Findings Comments () II 50 150 serum samples from women in 1st, 2nd and 3rd trimester of pregnancy in Warsaw. 72.7% of the sera were from women who reported taking multivitamin supplements containing vitamin D3 (71% of that group was taking 400 IU daily). BMI: Mean 250HD concentrations by BMI in 1st trimester differed significantly (p<0.05): BMI <21 (13 patients, 39 samples): 27.3 ng/mL BMI >25 (14 patients, 42 samples): 23.5 ng/mL Optimal 250HD levels (30-80 ng/ml) 30.0% Hypovitaminosis (20-30 ng/ml): 38.7%, Deficiency (10-20 ng/ml): 24.0% Severe deficiency (< 10 ng/ml) 7.3%
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