existing renal disease, elevation over the presence of fibrin degradation baseline by a factor of at least 2; products Liver involvement: alanine Coagulopathy: platelet count of aminotransferase, or total bilirubin level or disseminated ≤100x109/L at least twice the upper limit of normal intravascular coagulation, defined by for age; in patients with existing liver prolonged clotting times, low disease, elevation over baseline by a fibrinogen level, and the presence of factor of two fibrin degradation products; respiratory distress syndrome: involvement: alanine defined by acute onset of diffuse aminotransferase (ALT), aspartate pulmonary infiltrates and hypoxaemia in aminotransferase (AST), or total the absence of cardiac failure; or bilirubin level at least twice the upper evidence of diffuse capillary leak limit of normal for age; in patients with manifested by acute onset or existing liver disease, elevation over generalised oedema; or pleural or baseline by a factor of 2; peritoneal effusions with hypoalbuminaemia Adult respiratory distress syndrome, Generalised erythematous macular rash defined by acute onset of diffuse that may desquamate pulmonary infiltrates and hypoxaemia Soft tissue necrosis, including in the absence of cardiac failure; or necrotising fasciitis or myositis; or evidence of diffuse capillary leak gangrene. manifested by acute onset or A definite case is an illness fulfilling criteria IA generalised oedema; or pleural or and II (A and B). peritoneal effusions with A probable case is an illness fulfilling criteria IB hypoalbuminaemia; and II (A and B) where no other aetiology is Generalised erythematous macular identified. rash that may desquamate; (Working Group on Severe Streptococcal Infections 1993).
existing renal disease, elevation over baseline by a factor of at least 2; Coagulopathy: platelet count of ≤100x109/L or disseminated intravascular coagulation, defined by prolonged clotting times, low fibrinogen level, and the presence of fibrin degradation products; involvement: alanine aminotransferase (ALT), aspartate aminotransferase (AST), or total bilirubin level at least twice the upper limit of normal for age; in patients with existing liver disease, elevation over baseline by a factor of 2; Adult respiratory distress syndrome, defined by acute onset of diffuse pulmonary infiltrates and hypoxaemia in the absence of cardiac failure; or evidence of diffuse capillary leak manifested by acute onset or generalised oedema; or pleural or peritoneal effusions with hypoalbuminaemia; Generalised erythematous macular rash that may desquamate; the presence of fibrin degradation products Liver involvement: alanine aminotransferase, or total bilirubin level at least twice the upper limit of normal for age; in patients with existing liver disease, elevation over baseline by a factor of two respiratory distress syndrome: defined by acute onset of diffuse pulmonary infiltrates and hypoxaemia in the absence of cardiac failure; or evidence of diffuse capillary leak manifested by acute onset or generalised oedema; or pleural or peritoneal effusions with hypoalbuminaemia Generalised erythematous macular rash that may desquamate Soft tissue necrosis, including necrotising fasciitis or myositis; or gangrene. A definite case is an illness fulfilling criteria IA and II (A and B). A probable case is an illness fulfilling criteria IB and II (A and B) where no other aetiology is identified. (Working Group on Severe Streptococcal Infections 1993).
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