EQ-5D-5L and study Wolfs EQ-5D Cognition Application of VAS No 234 patients Application of Exploration of new Krabbe (1999) tool within existing (2007) EQ-5D+C Krabbe (1999) study in clinical trial (not designed Construct validity – practice specifically for this similar correlations in practice purpose) found between and MMSE, and Completion by EQ-5D+C and proxies. MMSE. Focusing effect EQ-5D adequate to detect differences, little gained by using EQ-5D+C EQ-5D was slightly more responsive than the EQ-5D+C EQ-5D Sleep TTO No Yang Valuation study Co-efficient for sleep Maintains Small sample size dimension non 3 level system
EQ-5D-5L and study Wolfs (2007) EQ-5D Cognition EQ-5D+C Application of Krabbe (1999) in practice VAS No 234 patients Construct validity – similar correlations found between and MMSE, and EQ-5D+C and MMSE. EQ-5D adequate to detect differences, little gained by using EQ-5D+C EQ-5D was slightly more responsive than the EQ-5D+C Application of Krabbe (1999) study in clinical practice Exploration of new tool within existing trial (not designed specifically for this purpose) Completion by proxies. Focusing effect Yang EQ-5D Sleep Valuation study TTO No Co-efficient for sleep dimension non Maintains 3 level system Small sample size
VKBrennan%20THESIS%20FINAL%20%28including%20appendix%29.docx