Syphilis - congenital Reporting Both confirmed cases and probable cases should be notified, including syphilis-related stiilbirth.1 case A confirmed case requires laboratory definitive evidence. Laboratory definitive evidence Mother and child both seropositive by a treponemal specific test2 AND One or more of the following: Direct demonstration of by any of the following: nucleic acid amplification Treponema pallidum (NAA) test, dark field microscopy, antibody or silver stain - in specimens from lesions, nasal discharge, placenta, umbilical cord, cerebrospinal fluid (CSF), amniotic fluid or autopsy material OR Detection of specific IgM in the child Treponema pallidum OR The serum non-treponemal3 serology titre at birth is at least fourfold greater than the child’s mother's titre. Probable case A probable case requires laboratory suggestive evidence AND clinical evidence. Laboratory suggestive evidence Direct demonstration of as described under laboratory definitive evidence Treponema pallidum (above), but without serological confirmation in the child. OR Child seropositive on non-treponemal testing in the absence of IgM testing OR A reactive CSF non-treponemal test (VDRL or RPR) in a child. OR A child who remains seropositive by a treponemal specific test at 15 months of age, which is confirmed either by another, different reactive treponemal specific test or a reactive non-treponemal test, in the absence of post-natal exposure to , including the non-venereal Treponema pallidum subspecies subsp. (Yaws) or subsp. (Bejel, endemic Treponema pallidum pertenue endemicum syphilis). Clinical evidence 1. Any evidence of congenital syphilis on physical examination OR 2. Any evidence of congenital syphilis on radiographs of long bones
Syphilis - congenital Reporting Both confirmed cases and probable cases should be notified, including syphilis-related stiilbirth.1 case A confirmed case requires laboratory definitive evidence. Laboratory definitive evidence Mother and child both seropositive by a treponemal specific test2 AND One or more of the following: Direct demonstration of Treponema pallidum by any of the following: nucleic acid amplification (NAA) test, dark field microscopy, antibody or silver stain - in specimens from lesions, nasal discharge, placenta, umbilical cord, cerebrospinal fluid (CSF), amniotic fluid or autopsy material OR Detection of Treponema pallidum specific IgM in the child OR The child’s serum non-treponemal3 serology titre at birth is at least fourfold greater than the mother's titre. Probable case A probable case requires laboratory suggestive evidence AND clinical evidence. Laboratory suggestive evidence Direct demonstration of Treponema pallidum as described under laboratory definitive evidence (above), but without serological confirmation in the child. OR Child seropositive on non-treponemal testing in the absence of IgM testing OR A reactive CSF non-treponemal test (VDRL or RPR) in a child. OR A child who remains seropositive by a treponemal specific test at 15 months of age, which is confirmed either by another, different reactive treponemal specific test or a reactive non-treponemal test, in the absence of post-natal exposure to Treponema pallidum , including the non-venereal subspecies Treponema pallidum subsp. pertenue (Yaws) or subsp. endemicum (Bejel, endemic syphilis). Clinical evidence 1. Any evidence of congenital syphilis on physical examination OR 2. Any evidence of congenital syphilis on radiographs of long bones
w-consolidated-case-definitions.docx