Low birth weight Study ref Design LoE N Intervention/observation/comparison population Results Limitations () SLR I 76 (11 RCTs; 65 observational studies) A modest positive relationship was identified Study studies between maternal 25(OH)D and offspring methodology birthweight in meta-analysis of three varied widely observational studies using log-transformed in terms of 25(OH)D concentrations after adjustment for design, potential confounding factors [pooled population, regression coefficient 5.63g/10% change vitamin D maternal 25(OH)D, 95%CI 1.11 to 10.16g], but assessment, not in those four studies using natural units, or exposure across intervention studies. measured and outcome definition.
Low birth weight Study ref Design LoE N Intervention/observation/comparison population Results Limitations () SLR I 76 studies (11 RCTs; 65 observational studies) A modest positive relationship was identified between maternal 25(OH)D and offspring birthweight in meta-analysis of three observational studies using log-transformed 25(OH)D concentrations after adjustment for potential confounding factors [pooled regression coefficient 5.63g/10% change maternal 25(OH)D, 95%CI 1.11 to 10.16g], but not in those four studies using natural units, or across intervention studies. Study methodology varied widely in terms of design, population, vitamin D assessment, exposure measured and outcome definition.
Vitamin%20D%20evidence%20evaluation%2022May17.docx