after exponentiation Costa 2009 Italy - 2007 37 Adjusted mean difference - from regression 107 - Frisbee 2010 US C8 2005-6 Results from continuous multivariate regression presented in quintiles Nelson 2010 US 2003-4 860 Adjusted means for - quartiles of PFAS 2010 - 2004 723 Adjusted means for - quartiles of PFOS (artic) - Eriksen 2013 - 1993-7 753 Results from continuous multivariate regression presented in octiles Fisher 2013 Health 2007-9 2345 Results from log continuous - q multivariate regression; OR for for elevated cholesterol Survey 2013 US C8 2005-6 521 Change in LDL-C in tertiles - e & 2010 of change in PFAS (longitudinal analysis) - e 2013 US C8 2005-11 Hazard ratio for developing hypercholesterolemia reported) based on cumulative estimated PFOA exposure over 20 years or blood data from 2005-6 - Starling 2014 MoBA 2003-4 891 Adjusted regression using quartiles of natural log -PFAS, reported after back-transformation - Geiger 2014 US 815 Adjusted regression by <19 tertiles of PFAS years 2015 US C8 2845 Incidence of - e hypercholesterolaemia not assessed as self-report was not validated estimate included in this review,-: not referred to in the review; OR: odds ratio, c: comment e- excluded q- included for qualitative assessment but not quantitative assessment Additional studies identified by FSANZ The following search strategy was conducted in PubMed on 15 Nov, 2016 (PFOA[All Fields] AND PFOA[All Fields] OR PFOS[All Fields] AND ("cholesterol"[MeSH Terms] OR "cholesterol"[All Fields])) AND "humans"[MeSH Terms]
after exponentiation Costa 2009 Italy - 2007 37 107 Adjusted mean difference from regression - Frisbee 2010 US C8 2005-6 Results from continuous multivariate regression presented in quintiles - Nelson 2010 US 2003-4 860 Adjusted means for quartiles of PFAS - 2010 (artic) - 2004 723 Adjusted means for quartiles of PFOS - Eriksen 2013 - 1993-7 753 Results from continuous multivariate regression presented in octiles - Fisher 2013 Health Survey 2007-9 2345 for Results from log continuous multivariate regression; OR for elevated cholesterol - q 2013 US C8 2005-6 & 2010 521 Change in LDL-C in tertiles of change in PFAS (longitudinal analysis) - e 2013 US C8 2005-11 Hazard ratio for developing hypercholesterolemia based on cumulative estimated PFOA exposure over 20 years or blood data from 2005-6 - e Starling 2014 MoBA 2003-4 891 Adjusted regression using quartiles of natural log -PFAS, reported after back-transformation - Geiger 2014 US 815 <19 years Adjusted regression by tertiles of PFAS - 2015 US C8 estimate 2845 Incidence of hypercholesterolaemia not assessed as self-report was not validated - e OR: odds ratio, included in this review,-: not referred to in the review; c: comment e- excluded q- included for qualitative assessment but not quantitative assessment Additional studies identified by FSANZ The following search strategy was conducted in PubMed on 15 Nov, 2016 (PFOA[All Fields] AND PFOA[All Fields] OR PFOS[All Fields] AND ("cholesterol"[MeSH Terms] OR "cholesterol"[All Fields])) AND "humans"[MeSH Terms] reported)
w6.sd1-Hazard-assessment-report.docx