H2-blockers mechanisms, some of which may not involve mushrooms angiogenesis Curcumin Cinnamon Garlic Spinach chloroplast glycoglycerolipids – synthetic angiogenesis inhibitors epigenetic effects: vorinostat (SAHA) at low doses (-) HDACs – valproic acid at low (-) HATs – Apicidin (fungal metabolite) (-) HDACs Aromatase inhibitors (-) Aromatase inhibits the proliferation of breast cancer Synthetic: Arimidex, Femara Natural: Mushrooms Aspirin (ASA) (-) Arachidonic acid cascade (-) COX1 and COX2 (+) mTOR B Bakuchi seed ( – ( Leaf Benzodiazepines Epigenetic mechanisms: examples: BET bromodomain inhibitors alprazolam => selectively bind to acetyl lysine midazolam modules of BET family B Vitamins (primarily Folic acid (+) DNA methylation risk of colon cancer ⬇ has the anti-cancer effects) (+) stabilization of tumor suppressor genes => (-) LOH Bitter Melon Extract (Momordica charantia) 5% solution in in vivo Ingredients: (-) cell proliferation anti-cancer effects in vitro for breast cancer charantin (+) apoptosis in cancer cells pancreatic cancer, nasopharyngeal cancer, mormordin (+) cell cycle arrest and prostate cancer & polyphenols Black Pepper Root ( Boswellic acid (Frankincense) (-) topoisomerase I and II (-) LOX (+)Caspace and PARP cleavage 3-Bromopyruvate dual metabolic disruptor (-) mitochondrial OxPhos
H2-blockers mechanisms, some of which may not involve mushrooms angiogenesis Curcumin Cinnamon Garlic Spinach – chloroplast glycoglycerolipids synthetic angiogenesis inhibitors epigenetic effects: vorinostat (SAHA) – at low doses (-) HDACs valproic acid – at low (-) HATs Apicidin (fungal metabolite) (-) HDACs Aromatase inhibitors (-) Aromatase inhibits the proliferation of breast cancer Synthetic: Arimidex, Femara Natural: Mushrooms Aspirin (ASA) (-) Arachidonic acid cascade (-) COX1 and COX2 (+) mTOR B – Bakuchi seed ( Leaf ( Benzodiazepines Epigenetic mechanisms: examples: BET bromodomain inhibitors alprazolam => selectively bind to acetyl lysine midazolam modules of BET family B Vitamins (primarily Folic acid (+) DNA methylation ⬇ risk of colon cancer has the anti-cancer effects) (+) stabilization of tumor suppressor genes => (-) LOH Bitter Melon Extract (Momordica charantia) 5% solution in in vivo Ingredients: (-) cell proliferation anti-cancer effects in vitro for breast cancer charantin (+) apoptosis in cancer cells pancreatic cancer, nasopharyngeal cancer, mormordin (+) cell cycle arrest and prostate cancer & polyphenols Black Pepper Root ( Boswellic acid (Frankincense) (-) topoisomerase I and II (-) LOX (+)Caspace and PARP cleavage 3-Bromopyruvate dual metabolic disruptor (-) mitochondrial OxPhos
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