Parallel To investigate 119 volunteers (mean The control group Food intake and Relatively low Significant Ma 2013 the effects of age 59 yrs) with received compliance attrition rate, decrease in total naked oats on metabolic syndrome structured dietary recorded. Venous statistical and LDL-C people with and Type 2 diabetes intervention fasting blood analysis showed following naked Type 2 diabetes but normal cholesterol including intensive samples were no effect of oat intervention. using a concentration (43% nutrition education taken. Total and experimental No significant randomised male). and systematic HDL-C were treatment on change in in controlled trial. meal plans. The analysed using dropouts. experimental the enzymatic group received the method, and same diet advice was calculated. and meal plans X2 tests and with the addition ANOVAs were of 50 g/day of used for between naked oats (2.5 group beta glucan/day) comparisons. replacing other staple products such as rice, wheat flour, corn and millet. 1wk run in, 30 day experiment. Maki 2003 To assess the 29 Weight loss diet Compliance by High attrition. Significant clinical efficacy hypercholesterolaemic (NCEP Step 1 return of unused Significantly decrease in of consuming children (6-14y, 72% dietary guidelines) packets. Dietary lower energy in per-protocol in male). 18 completed with 2 portions of intake by 3d diet intake in -glucan analysis, but not cereals in study per protocol. b-glucan record at baseline treatment ITT. blood containing cereal and in each test period. cholesterol (3g of soluble period. Blood decrease in total concentration in fibre) or low fibre lipids measured in cholesterol and children. cereal per day. certified pathology HDL-C. 4wk run-in, 1wk laboratory, LDL-C Change in LDL-C baseline, then 2x calculated. significant in 4wk test periods. Subgroup analysis subjects below, by BMI. but not above, RMANOVA median BMI. analysis.
Ma 2013 Parallel To investigate the effects of naked oats on people with Type 2 diabetes using a randomised controlled trial. 119 volunteers (mean age 59 yrs) with metabolic syndrome and Type 2 diabetes but normal cholesterol concentration (43% male). The control group received structured dietary intervention including intensive nutrition education and systematic meal plans. The experimental group received the same diet advice and meal plans with the addition of 50 g/day of naked oats (2.5 beta glucan/day) replacing other staple products such as rice, wheat flour, corn and millet. 1wk run in, 30 day experiment. Food intake and compliance recorded. Venous fasting blood samples were taken. Total and HDL-C were analysed using the enzymatic method, and was calculated. X2 tests and ANOVAs were used for between group comparisons. Relatively low attrition rate, statistical analysis showed no effect of experimental treatment on dropouts. Significant decrease in total and LDL-C following naked oat intervention. No significant change in in Maki 2003 To assess the clinical efficacy of consuming in cereals in blood cholesterol concentration in children. 29 hypercholesterolaemic children (6-14y, 72% male). 18 completed study per protocol. Weight loss diet (NCEP Step 1 dietary guidelines) with 2 portions of b-glucan containing cereal (3g of soluble fibre) or low fibre cereal per day. 4wk run-in, 1wk baseline, then 2x 4wk test periods. Compliance by return of unused packets. Dietary intake by 3d diet record at baseline and in each test period. Blood lipids measured in certified pathology laboratory, LDL-C calculated. Subgroup analysis by BMI. RMANOVA analysis. High attrition. Significantly lower energy intake in -glucan treatment period. Significant decrease in in per-protocol analysis, but not ITT. decrease in total cholesterol and HDL-C. Change in LDL-C significant in subjects below, but not above, median BMI.
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