TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 12 7.2. Environmental Effects Assessment 12 7.2.1. Predicted No-Effect Concentration 13 7.3. Environmental Risk Assessment 13 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity oral 16 – B.2. Irritation skin (in vitro) 16 – B.3. Repeat dose toxicity 17 B.4. Genotoxicity bacteria 18 – B.5. Genotoxicity in vitro 19 – B.6. Developmental toxicity 20 Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. biodegradability 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 22 C.2.4. Inhibition of microbial activity 23 BIBLIOGRAPHY 24
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 12 7.2. Environmental Effects Assessment 12 7.2.1. Predicted No-Effect Concentration 13 7.3. Environmental Risk Assessment 13 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity – oral 16 B.2. Irritation – skin (in vitro) 16 B.3. Repeat dose toxicity 17 B.4. Genotoxicity – bacteria 18 B.5. Genotoxicity – in vitro 19 B.6. Developmental toxicity 20 Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. biodegradability 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 22 C.2.4. Inhibition of microbial activity 23 BIBLIOGRAPHY 24
STD1450FR.docx