72 79 Parsa ADDIN 92 93 EN.CITE (discordance in direction and statistical eGFR (mL/min/1.73 0.71 0.42 (-1.78, 2.62) 2012 USA 868 rs16890979 in SCL2A9 NA MD significance) m2) Yang ADDIN EN.CITE Log eGFR Genetic risk score of 8 0.91 β 0.001 (-0.01, 0.02) 2010 American 23,844 (5)* 6.0% (mL/min/1.73 m2) SUA-related SNPs Tabara ADDIN EN.CITE eGFR (mL/min/1.73 Genetic risk score of 3 <0.001 β -0.11 (NA, NA) 2010 Japanese 5,165 (2)* NA m2) SUA-related SNPs No overall result 7 SNPs in SCL2A9: 0.52 (NA, NA) 0.002 rs16890979 Voruganti ADDIN EN.CITE 0.52 (NA, NA) 0.002 rs6832439 Residual American eGFR (mL/min/1.73 2014 3,604 (3)* 5.3% Indians m2) variance¶ 0.22 (NA, NA) 0.08 rs6449213 0.58 (NA, NA) 0.001 rs13131257 0.44 (NA, NA) 0.004 rs737267
72 79 92 93 (discordance in direction and statistical significance) Parsa ADDIN EN.CITE 2012 USA 868 eGFR (mL/min/1.73 m2) rs16890979 in SCL2A9 NA MD 0.42 (-1.78, 2.62) 0.71 Yang ADDIN EN.CITE 2010 American 23,844 (5)* Log eGFR (mL/min/1.73 m2) Genetic risk score of 8 SUA-related SNPs 6.0% β 0.001 (-0.01, 0.02) 0.91 Tabara ADDIN EN.CITE 2010 Japanese 5,165 (2)* eGFR (mL/min/1.73 m2) Genetic risk score of 3 SUA-related SNPs NA β -0.11 (NA, NA) <0.001 Voruganti ADDIN EN.CITE 2014 American Indians 3,604 (3)* eGFR (mL/min/1.73 m2) 7 SNPs in SCL2A9: 5.3% Residual variance¶ No overall result rs16890979 0.52 (NA, NA) 0.002 rs6832439 0.52 (NA, NA) 0.002 rs6449213 0.22 (NA, NA) 0.08 rs13131257 0.58 (NA, NA) 0.001 rs737267 0.44 (NA, NA) 0.004
Supplementary%20material_v7%20-%20Final-2.docx