Abbreviations: MA, meta-analysis; CKD, chronic kidney disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; MD, mean difference; SMD, standard mean difference; NA, not available. * Quantitative analyses were not performed, because we suspected some of the reported data misused standard error as standard deviation. Supplementary table S5 General characteristics and main findings of the 107 Mendelian randomisation studies* SUA variance N/n Events Genetic instruments Type of Estimate effect Concordance in Author Year Population Outcomes (R2) explained P value (N studies)* (GI) metric (95%CI) overlapped MR by GI Anthropometric variables Appendicular lean 0.01 (NA, NA) 0.51 β 2016 UK 3,953 rs737267 in SCL2A9 NA mass (kg) Lyngdoh ADDIN EN.CITE 0.05 (-0.10, 0.19) 0.52 β 2012 Switzerland 6,184 Fat mass (kg) rs6855911 in SCL2A9 3.2% Burgess ADDIN EN.CITE Genetic risk score of 29 -0.12(-0.53, 0.57 NO ADDIN β 2015 European 7,158 BMI (kg/m2) NA SUA-related SNPs EN.CITE Palmer ADDIN EN.CITE -0.04 (-0.25, 0.16) NA (discordance in 2013 Danish 68,674 (2)* BMI (kg/m2) rs7442295 in SCL2A9 2.2% MD direction)
Abbreviations: MA, meta-analysis; CKD, chronic kidney disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; MD, mean difference; SMD, standard mean difference; NA, not available. * Quantitative analyses were not performed, because we suspected some of the reported data misused standard error as standard deviation. Supplementary table S5 General characteristics and main findings of the 107 Mendelian randomisation studies* Author Year Population N/n Events (N studies)* Outcomes Genetic instruments (GI) SUA variance (R2) explained by GI Type of metric Estimate effect (95%CI) P value Concordance in overlapped MR Anthropometric variables 2016 UK 3,953 Appendicular lean mass (kg) rs737267 in SCL2A9 NA β 0.01 (NA, NA) 0.51 Lyngdoh ADDIN EN.CITE 2012 Switzerland 6,184 Fat mass (kg) rs6855911 in SCL2A9 3.2% β 0.05 (-0.10, 0.19) 0.52 Burgess ADDIN EN.CITE 2015 European 7,158 BMI (kg/m2) Genetic risk score of 29 SUA-related SNPs NA β -0.12(-0.53, 0.57 NO ADDIN EN.CITE (discordance in direction) Palmer ADDIN EN.CITE 2013 Danish 68,674 (2)* BMI (kg/m2) rs7442295 in SCL2A9 2.2% MD -0.04 (-0.25, 0.16) NA
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