ATS - American Thoracic Society HMT - histone methyl transferase enzyme BPC- base peak chromatogram HPLC - high performance liquid chromatography system BSA Bovine serum albumin – HRP Horseradish peroxidase – CARS- Compensatory anti-inflammatory response syndrome ICU intensive care unit – ChAP-MS - chromatin affinity purification IL-1 Interlukin-1 with mass spectrometry K- lysine ChIP - chromatin immunoprecipitation KMT - lysine methyltransferases ChIP-seq - chromatin immunoprecipitation LC Liquid chromatography - sequencing – LC-MS/MS - liquid chromatography CID - collision induced dissociation – tandem mass spectrometry - citrullination of histone H3 LPS lipopolysaccharide – CLP cecal ligature and puncture – LPS Lipopolysaccharide – DA Data analysis – MALDI - matrix assisted laser desorption DC - direct current ionization DIC - disseminated intravascular MAP- Mean Arterial Pressure coagulopathy MDMs Monocyte derived macrophages – ECD - electron capture dissociation Me1- monomethylation ELISA - Enzyme linked immunosorbant Me2- dimethylation assay Me3- trimethylation ESI - electrospray ionization MHC histocompatibility complex ESICM - European Society of Intensive Care – Medicine MILP - integer linear optimization ETD - electron transfer dissociation MS - mass spectrometry FCS- Fetal calf serum MS/MS tandem mass spectrometry – FT-ICR - fourier transform ion cyclotron N Asparagine – resonance NETs - neutrophil extracellular traps G-CSF- granulocyte colony stimulating factor NT- non tolerisable genes HAT - histone acetyl transferase OP- over propionylation HAT- Histone acetylase PADI - peptidyl arginine deiminase HDAC- Histone deactylase PAMP - pathogen associated molecular pattern HILIC - Hydrophilic interaction chromatography PBMCs Peripheral blood mononuclear – cells HKMT- histone lysine methyltransferase
ATS - American Thoracic Society BPC- base peak chromatogram BSA – Bovine serum albumin CARS- Compensatory anti-inflammatory response syndrome ChAP-MS - chromatin affinity purification with mass spectrometry ChIP - chromatin immunoprecipitation ChIP-seq - chromatin immunoprecipitation - sequencing CID - collision induced dissociation - citrullination of histone H3 CLP – cecal ligature and puncture DA – Data analysis DC - direct current DIC - disseminated intravascular coagulopathy ECD - electron capture dissociation ELISA - Enzyme linked immunosorbant assay ESI - electrospray ionization ESICM - European Society of Intensive Care Medicine ETD - electron transfer dissociation FCS- Fetal calf serum FT-ICR - fourier transform ion cyclotron resonance G-CSF- granulocyte colony stimulating factor HAT - histone acetyl transferase HAT- Histone acetylase HDAC- Histone deactylase HILIC - Hydrophilic interaction chromatography HKMT- histone lysine methyltransferase HMT - histone methyl transferase enzyme HPLC - high performance liquid chromatography system HRP – Horseradish peroxidase ICU – intensive care unit IL-1 Interlukin-1 K- lysine KMT - lysine methyltransferases LC – Liquid chromatography LC-MS/MS - liquid chromatography – tandem mass spectrometry LPS – lipopolysaccharide LPS – Lipopolysaccharide MALDI - matrix assisted laser desorption ionization MAP- Mean Arterial Pressure MDMs – Monocyte derived macrophages Me1- monomethylation Me2- dimethylation Me3- trimethylation MHC – histocompatibility complex MILP - integer linear optimization MS - mass spectrometry MS/MS – tandem mass spectrometry N – Asparagine NETs - neutrophil extracellular traps NT- non tolerisable genes OP- over propionylation PADI - peptidyl arginine deiminase PAMP - pathogen associated molecular pattern PBMCs – Peripheral blood mononuclear cells
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