Group Number and Sex Dose Mortality of Animals mg/kg bw 1 5 male, 5 female 2000 0 LD50 > 2000 mg/kg bw Signs of Toxicity - Local None of Toxicity - Systemic None Effects in Organs No test-related changes were noted at necroscopy. Remarks - Results No microscopic examination of tissues was carried out. The notified chemical is of low toxicity via the dermal route. Eastman Kodak (2004l) 7.4. Irritation skin – Notified chemical OECD TG 404 Acute Dermal Irritation/Corrosion. EC Directive 92/69/EEC B.4 Acute Toxicity (Skin Irritation). Species/Strain Rabbit/Albino (Hra: (NZW)SPF) Number of Animals 3 Vehicle The test substance was moistened with water. Observation Period 72 h Type of Dressing Occlusive/Semi-occlusive. Remarks - Method At the end of the 4 h exposure period the application site was rinsed with running water. Lesion Mean Score* Maximum Maximum Duration Maximum Value at End Animal No. of Any Effect of Observation Period 1 2 3 0 0 0 0 - 0 Erythema/Eschar 0 0 0 0 - 0 Oedema *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results No of irritation were evident at any time during the study. The notified chemical is non-irritating to skin. Eastman (2003i) 7.5. Irritation - eye 7.5.1 Eye Irritation in vivo Notified chemical OECD TG 405 Acute Eye Irritation/Corrosion. EC Directive 92/69/EEC B.5 Acute Toxicity (Eye Irritation). Species/Strain Rabbit/Albino (Hra: (NZW)SPF) Number of Animals 3 Observation Period 72 h Remarks - Method 0.1g of the notified chemical was administered as received, as a brown powder. Three additional rabbits were treated similarly, except that the eyes were immediately irrigated with running distilled water.
Group Number and Sex of Animals Dose mg/kg bw Mortality 1 5 male, 5 female 2000 0 LD50 > 2000 mg/kg bw Signs of Toxicity - Local None of Toxicity - Systemic None Effects in Organs No test-related changes were noted at necroscopy. Remarks - Results No microscopic examination of tissues was carried out. The notified chemical is of low toxicity via the dermal route. Eastman Kodak (2004l) 7.4. Irritation – skin Notified chemical OECD TG 404 Acute Dermal Irritation/Corrosion. EC Directive 92/69/EEC B.4 Acute Toxicity (Skin Irritation). Species/Strain Rabbit/Albino (Hra: (NZW)SPF) Number of Animals 3 Vehicle The test substance was moistened with water. Observation Period 72 h Type of Dressing Occlusive/Semi-occlusive. Remarks - Method At the end of the 4 h exposure period the application site was rinsed with running water. Lesion Mean Score* Animal No. Maximum Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Erythema/Eschar 0 0 0 0 - 0 Oedema 0 0 0 0 - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results No of irritation were evident at any time during the study. The notified chemical is non-irritating to skin. Eastman (2003i) 7.5. Irritation - eye 7.5.1 Eye Irritation in vivo Notified chemical OECD TG 405 Acute Eye Irritation/Corrosion. EC Directive 92/69/EEC B.5 Acute Toxicity (Eye Irritation). Species/Strain Rabbit/Albino (Hra: (NZW)SPF) Number of Animals 3 Observation Period 72 h Remarks - Method 0.1g of the notified chemical was administered as received, as a brown powder. Three additional rabbits were treated similarly, except that the eyes were immediately irrigated with running distilled water.
STD1101FR.docx