Appendix 3 Characteristics of included studies – Reference Study Objectives Participants & sample Interventions Methods Confounders Results Notes design size Comparison of 31 healthy females made with Compliance and Controlled by Non-significant Abrahamsson 1994 effect between aged 20-46 y, majority oat or wheat bran. dietary intake by design decrease in total, oat and wheat with normal cholesterol. 7d food records 7d weighed food and measured LDL-C, and fibre on 27 included in final for compliance records. Lipids by food intake. Dietary intakes cholesterol analysis. and food intake. measured by well-matched metabolism in Average -glucan enzymatic assay. between strata. healthy women intake 7.5g per LDL-C measured day in oat group, directly. 1.1g per day in ANOVA analysis wheat group. 1wk run-in period then 2x 5wk periods. Amundsen Assess effects 20 subjects (56% men) Whole diet 7d food record for Minimised by Significant Power of addition of oat with provided, baseline dietary design decrease in calculation 2003 bran hypercholesterolaemia. prepared with oat intakes, food and provision of and LDL-C, performed for concentrate to a 16 completed study. bran concentrate for consumption of all foods. total cholesterol. low saturated fat or placebo diet. test and non-test decrease in and cholesterol Test diet provided foods. diet. 5 g (2.7 g soluble) LDL-C calculated. -glucan per day. t-test analysis 2x 3wk periods with 2.5wk washout.
Appendix 3 – Characteristics of included studies Reference Study design Objectives Participants & sample size Interventions Methods Confounders Results Notes Abrahamsson 1994 Comparison of effect between oat and wheat fibre on cholesterol metabolism in healthy women 31 healthy females aged 20-46 y, majority with normal cholesterol. 27 included in final analysis. made with oat or wheat bran. 7d food records for compliance and food intake. Average -glucan intake 7.5g per day in oat group, 1.1g per day in wheat group. 1wk run-in period then 2x 5wk periods. Compliance and dietary intake by 7d weighed food records. Lipids measured by enzymatic assay. LDL-C measured directly. ANOVA analysis Controlled by design and measured by food intake. Non-significant decrease in total, LDL-C, and Dietary intakes well-matched between strata. Amundsen 2003 Assess effects of addition of oat bran concentrate to a low saturated fat and cholesterol diet. 20 subjects (56% men) with hypercholesterolaemia. 16 completed study. Whole diet provided, prepared with oat bran concentrate or placebo diet. Test diet provided 5 g (2.7 g soluble) -glucan per day. 2x 3wk periods with 2.5wk washout. 7d food record for baseline dietary intakes, food for consumption of test and non-test foods. LDL-C calculated. t-test analysis Minimised by design and provision of all foods. Significant decrease in and LDL-C, decrease in Power calculation performed for total cholesterol.
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