OLOA 232E is slightly to moderate irritating to skin. Chevron Chemical Company (1972). 7.4 Irritation - eye OLOA 232E Similar to OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New Zealand White Number of Animals 6 Observation Period 7 days Remarks - Method None Lesion Mean Score* Maximum Maximum Maximum Value at Value Duration of Any End of Observation Effect Period 0.9 2 7 days 1 Conjunctiva: redness 0.1 1 1 day 0 Conjunctiva: chemosis 0.3 2 1 day 0 Conjunctiva: discharge 0 - - 0 Corneal opacity 0 - - 0 Iridial inflammation *Calculated on the basis of the scores at 24, 48, and 72 hours for ALL animals. Remarks - Results The mean Draize scores for redness, chemosis and discharge at 1 hour were 1.8, 1 and 1.5, respectively. OLOA 232E is slightly irritating to the eye. Chevron Chemical Company (1972). 7.5. Skin sensitisation (1) OLOA 232E OECD TG 406 Skin Sensitisation Buehler method – Species/Strain Guinea pig/Hartley preliminary study Not reported. main Number of Animals Test Group: Control Group: 15 (low-dose) 10 (first challenge control) 15 (high-dose) 10 (second challenge control) 10 (irritation control) induction phase Induction Concentration: topical: 5% in mineral oil (low dose 25% in mineral oil (high dose group) Signs of Irritation Number of animals showing skin reactions (Draize score 1) after inductions were listed below: Animal Number of Animals Showing Skin Reactions after 1st induction 5th induction 10th induction 24 h 48 h 24 h 24 h Test Group 0/15 1/15 9/15 1/15 Low-dose
OLOA 232E is slightly to moderate irritating to skin. Chevron Chemical Company (1972). 7.4 Irritation - eye OLOA 232E Similar to OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New Zealand White Number of Animals 6 Observation Period 7 days Remarks - Method None Lesion Mean Score* Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period Conjunctiva: redness 0.9 2 7 days 1 Conjunctiva: chemosis 0.1 1 1 day 0 Conjunctiva: discharge 0.3 2 1 day 0 Corneal opacity 0 - - 0 Iridial inflammation 0 - - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for ALL animals. Remarks - Results The mean Draize scores for redness, chemosis and discharge at 1 hour were 1.8, 1 and 1.5, respectively. OLOA 232E is slightly irritating to the eye. Chevron Chemical Company (1972). 7.5. Skin sensitisation (1) OLOA 232E OECD TG 406 Skin Sensitisation – Buehler method Species/Strain Guinea pig/Hartley preliminary study Not reported. main Number of Animals Test Group: 15 (low-dose) 15 (high-dose) Control Group: 10 (first challenge control) 10 (second challenge control) 10 (irritation control) induction phase Induction Concentration: topical: 5% in mineral oil (low dose 25% in mineral oil (high dose group) Signs of Irritation Number of animals showing skin reactions (Draize score 1) after inductions were listed below: Animal Number of Animals Showing Skin Reactions after 1st induction 5th induction 10th induction 24 h 48 h 24 h 24 h Test Group Low-dose 0/15 1/15 9/15 1/15
STD1087FR.docx