Animal Challenge Concentration Number of Animals Showing Skin Reactions after Challenge 24 h 48 h undiluted 0/20 0/20 Test Group undiluted 0/10 0/10 Control There was no evidence of reactions indicative of skin sensitisation to the notified chemical under the conditions of the test. Notox (2001m). 7.7. Repeat dose toxicity Notified chemical. OECD TG 412 Repeated Dose Inhalation Toxicity: 28-day or 14-day Study. EC Directive 92/69/EEC B.8 Repeated Dose (28 Days) Toxicity (Inhalation). Species/Strain Rat/Wistar. Route of Administration Inhalation oro-nasal exposure. – Exposure Information Total exposure days: 28 days; Dose regimen: 5 days per week; Duration of exposure (inhalation/dermal): 6 Post-exposure observation period: 14 days. Vehicle None. Physical Form Vapour. Number and Sex Dose/Concentration Mortality of Animals ppm Nominal Actual I (control) 5/sex 0 0 0/10 II (low dose) 1000 997 “ “ III (lower-mid dose) 4000 3984 “ “ IV (upper-mid dose) 10000 10018 “ “ V (high dose) 20000 19644 “ “ VI (control recovery) 0 0 “ “ VII (high dose recovery) 20000 19644 “ “ Clinical Observations A trend to reduction in bodyweight was noted in high dose males; this was statistically significant by day 21 and also in the recovery group but not observed in females. A slightly lower overall food intake in high dose males accompanied by a lower food conversion efficiency.
Animal Challenge Concentration Number of Animals Showing Skin Reactions after Challenge 24 h 48 h Test Group undiluted 0/20 0/20 Control undiluted 0/10 0/10 There was no evidence of reactions indicative of skin sensitisation to the notified chemical under the conditions of the test. Notox (2001m). 7.7. Repeat dose toxicity Notified chemical. OECD TG 412 Repeated Dose Inhalation Toxicity: 28-day or 14-day Study. EC Directive 92/69/EEC B.8 Repeated Dose (28 Days) Toxicity (Inhalation). Species/Strain Rat/Wistar. Route of Administration Inhalation – oro-nasal exposure. Exposure Information Total exposure days: 28 days; Dose regimen: 5 days per week; Duration of exposure (inhalation/dermal): 6 Post-exposure observation period: 14 days. Vehicle None. Physical Form Vapour. Number and Sex of Animals Dose/Concentration ppm Mortality Nominal Actual I (control) 5/sex 0 0 0/10 II (low dose) “ 1000 997 “ III (lower-mid dose) “ 4000 3984 “ IV (upper-mid dose) “ 10000 10018 “ V (high dose) “ 20000 19644 “ VI (control recovery) “ 0 0 “ VII (high dose recovery) “ 20000 19644 “ Clinical Observations A trend to reduction in bodyweight was noted in high dose males; this was statistically significant by day 21 and also in the recovery group but not observed in females. A slightly lower overall food intake in high dose males accompanied by a lower food conversion efficiency.
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