To compare the 24 dietitians and oat bran Compliance by Total and No significant GI symptoms Swain 1990 effect of hospital employees group consumed recording of saturated fat difference in blood enables subjects oat bran (20% male, 23-49y). muffins and test food intake. intake higher cholesterol to correctly and low fibre Normal cholesterol entrees containing Dietary intake by during test concentration. identify refined-wheat concentration. 20 oat bran to give 4d food records in phase. intervention product on blood completed study. 100g oat bran per week 5 of cholesterol day (86% intervention. concentration. compliance). Blood lipids Control group measured received placebo enzymatically, foods made with LDL-C measured refined low-fibre directly. wheat. RMANOVA with 1wk run-in, 2x 6wk intervention with test. 2wk washout. Theuwissen To compare the 43 mildly Muesli with Compliance by Minimised by Significant Power 2007 effects of hypercholesterolaemic fibre (control) or returned cross-over decrease in total calculation for intake participants (48% male, from oat packages and design cholesterol and LDL-C. alone or in 18-65y). 42 completed fibre was record of any LDL-C. No 2 subjects were combination with study, but 2 excluded consumed 2x daily protocol change in HDL-C. excluded due to and plant stanol from analyses. at least 5 hours deviations. Dietary elevated liver esters on blood apart. Mean intake by FFQ at enzymes lipid intake was end of intervention throughout study concentration 4.8g per day in the phases. Blood (including and lipid oat group. lipids measured control period). metabolism. 3x 4wk enzymatically, Intervention of intervention with LDL-C calculated. combined of 2wk washout. ANOVA with and Tukey post-hoc sterols was not analysis. considered.
Swain 1990 To compare the effect of oat bran and low fibre refined-wheat product on blood cholesterol concentration. 24 dietitians and hospital employees (20% male, 23-49y). Normal cholesterol concentration. 20 completed study. oat bran group consumed muffins and entrees containing oat bran to give 100g oat bran per day (86% compliance). Control group received placebo foods made with refined low-fibre wheat. 1wk run-in, 2x 6wk intervention with 2wk washout. Compliance by recording of test food intake. Dietary intake by 4d food records in week 5 of intervention. Blood lipids measured enzymatically, LDL-C measured directly. RMANOVA with test. Total and saturated fat intake higher during test phase. No significant difference in blood cholesterol concentration. GI symptoms enables subjects to correctly identify intervention Theuwissen 2007 To compare the effects of intake alone or in combination with and plant stanol esters on blood lipid concentration and lipid metabolism. 43 mildly hypercholesterolaemic participants (48% male, 18-65y). 42 completed study, but 2 excluded from analyses. Muesli with fibre (control) or from oat fibre was consumed 2x daily at least 5 hours apart. Mean intake was 4.8g per day in the oat group. 3x 4wk intervention with 2wk washout. Compliance by returned packages and record of any protocol deviations. Dietary intake by FFQ at end of intervention phases. Blood lipids measured enzymatically, LDL-C calculated. ANOVA with Tukey post-hoc analysis. Minimised by cross-over design Significant decrease in total cholesterol and LDL-C. No change in HDL-C. Power calculation for LDL-C. 2 subjects were excluded due to elevated liver enzymes throughout study (including control period). Intervention of combined of and sterols was not considered.
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