reported Difference Expected in baseline Khandelwal Sealed 11% low low low low low low high Blinded outcomes LDL-C 2009 envelopes attrition sequence reported between groups Participants Unclear Expected Not but not No Ruiu 2009 ? ? low high low low low method of Not blinded outcomes described personnel attrition randomisation reported blinded Unclear Expected Shaghaghi Not Not Not 11% ? method of ? ? ? low low outcomes low 2014 described described described attrition randomisation reported Participants Difference Unclear Expected Not but not No in protocol Sialvera 2012 ? ? low high low low high method of Not blinded outcomes described personnel attrition between randomisation reported blinded arms. Stratified for Expected Soderholm Not Not 7% low total chol. and ? low ? low low outcomes low 2012 described described attrition gender reported Dietary Unclear Not Not 2% intake Weidner 2008 ? ? low ? low high low method of described described attrition data not randomisation reported Appendix 4 GRADE summary of findings table – GRADE evidence profile of systematic review FSANZ’s updated Question: What is the effect of phytosterol intake on blood cholesterol concentrations in adults? Source: FSANZ update of Demonty et al. 2009 and Ras et al 2013 systematic reviews.
reported Khandelwal 2009 low sequence low Sealed envelopes low low Blinded low 11% attrition low Expected outcomes reported high Difference in baseline LDL-C between groups Ruiu 2009 ? Unclear method of randomisation ? Not described low Participants but not personnel blinded high Not blinded low No attrition low Expected outcomes reported low Shaghaghi 2014 ? Unclear method of randomisation ? Not described ? Not described ? Not described low 11% attrition low Expected outcomes reported low Sialvera 2012 ? Unclear method of randomisation ? Not described low Participants but not personnel blinded high Not blinded low No attrition low Expected outcomes reported high Difference in protocol between arms. Soderholm 2012 low Stratified for total chol. and gender ? Not described low ? Not described low 7% attrition low Expected outcomes reported low Weidner 2008 ? Unclear method of randomisation ? Not described low ? Not described low 2% attrition high Dietary intake data not reported low Appendix 4 – GRADE summary of findings table GRADE evidence profile of FSANZ’s updated systematic review Question: What is the effect of phytosterol intake on blood cholesterol concentrations in adults? Source: FSANZ update of Demonty et al. 2009 and Ras et al 2013 systematic reviews.
Systematic%20review%20phytosterols%20and%20cholesterol.docx