Parallel To compare the Adults (aged 20-65, All subjects Compliance by Large Non-significant 4 study strata, effects of %men unclear) with followed and returning unused differences in increase in total regular diet with addition of oat hypercholesterolaemia. NCEP step 1 diet. packets and baseline cholesterol. oat bran, regular 1990 bran to a low fat 81 subjects assigned to Oat group food records. saturated fat No LDL-C data diet with low cholesterol 4 groups, 68 completed consumed 50g Dietary and fibre intakes and HDL processed oat (NCEP) diet. study. In analysis, 18 in unprocessed oats. assessment of 3d at baseline. decreased in both bran, low fat low oat bran group and 15 2wk run-in, then food records at groups (only cholesterol diet in control group. 12wk trial with baseline and 3 reported or low fat low follow-up every times during graphically) cholesterol diet 4wks. intervention. with oat bran. Lipid analysis by Addition of oat standard methods bran to a regular (note no LDL-C diet was not data) included as no RMANOVA adequate control analysis. groups for these strata. Gerhardt 1998 Parallel To compare the In oat bran and rice Subjects Compliance by Differences in Significant Rice bran effects of oat starch placebo groups: consumed 84g/d returning unused baseline SFA decrease in total not considered bran and rice 33 moderately of oat bran (3.3g packets, dietary and fibre intake. cholesterol and in analysis. bran for the hypercholesterolaemic soluble fibre) or intake by weekly LDL-C. No GI symptoms in treatment of adults (52% male).Final placebo (84g/d of food records. difference in oat bran group hyperlipidaemia. analysis of 30 adults, rice starch) in Blood lipids reported. 13 in oat bran and 17 in addition to usual measured in rice starch placebo. low-fat diet. 6wk pathology trial. laboratory, LDL-C calculated. ANOVA with analysis.
1990 Parallel To compare the effects of addition of oat bran to a low fat low cholesterol (NCEP) diet. Adults (aged 20-65, %men unclear) with hypercholesterolaemia. 81 subjects assigned to 4 groups, 68 completed study. In analysis, 18 in oat bran group and 15 in control group. All subjects followed and NCEP step 1 diet. Oat group consumed 50g unprocessed oats. 2wk run-in, then 12wk trial with follow-up every 4wks. Compliance by returning unused packets and food records. Dietary assessment of 3d food records at baseline and 3 times during intervention. Lipid analysis by standard methods (note no LDL-C data) RMANOVA analysis. Large differences in baseline saturated fat and fibre intakes at baseline. Non-significant increase in total cholesterol. No LDL-C data and HDL decreased in both groups (only reported graphically) 4 study strata, regular diet with oat bran, regular diet with processed oat bran, low fat low cholesterol diet or low fat low cholesterol diet with oat bran. Addition of oat bran to a regular diet was not included as no adequate control groups for these strata. Gerhardt 1998 Parallel To compare the effects of oat bran and rice bran for the treatment of hyperlipidaemia. In oat bran and rice starch placebo groups: 33 moderately hypercholesterolaemic adults (52% male).Final analysis of 30 adults, 13 in oat bran and 17 in rice starch placebo. Subjects consumed 84g/d of oat bran (3.3g soluble fibre) or placebo (84g/d of rice starch) in addition to usual low-fat diet. 6wk trial. Compliance by returning unused packets, dietary intake by weekly food records. Blood lipids measured in pathology laboratory, LDL-C calculated. ANOVA with analysis. Differences in baseline SFA and fibre intake. Significant decrease in total cholesterol and LDL-C. No difference in Rice bran not considered in analysis. GI symptoms in oat bran group reported.
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx