TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 5 5.4. Release 6 5.5. Disposal 6 5.6. Public exposure 6 6. PHYSICAL AND CHEMICAL PROPERTIES 6 7. TOXICOLOGICAL INVESTIGATIONS 11 7.1. Acute toxicity oral 11 – 7.2. toxicity dermal 11 – 7.3. Acute toxicity inhalation 12 – 7.4. Irritation skin 12 – 7.5. Irritation eye 12 – 7.6. Skin sensitisation mouse local lymph node assay (LLNA) 13 – 7.7. Repeat dose toxicity - oral 14 7.8. Genotoxicity bacteria 19 – 7.9. Genotoxicity in vitro 19 – 7.10. Genotoxicity in vivo 20 – 8. ENVIRONMENT 21 8.1. Environmental fate 21 8.1.1. biodegradability 21 8.1.2. Bioaccumulation 22 8.2. Ecotoxicological investigations 22 8.2.1. Acute toxicity to fish 22 8.2.2. Acute toxicity to aquatic invertebrates 23 8.2.3. Algal growth inhibition test 24 8.2.4. Inhibition of microbial activity 25 9. RISK ASSESSMENT 26 9.1. Environment 26 9.1.1. Environment exposure assessment 26 – 9.1.2. Environment effects assessment 27 – 9.1.3. Environment risk characterisation 27 – 9.2. Human health 28 9.2.1. Occupational health and safety exposure assessment 28 – 9.2.2. Public health exposure assessment 29 – 9.2.3. Human health effects assessment 29 – 9.2.4. Occupational health and safety risk characterisation 29 – 9.2.5. Public health risk characterisation 30 – 10. CONCLUSIONS ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND – HUMANS 30 10.1. Hazard classification 30 10.2. Environmental risk assessment 30 10.3. Human health risk assessment 30 10.3.1. Occupational health and safety 30 10.3.2. Public health 30 11. MATERIAL SAFETY DATA SHEET 31 11.1. Material Safety Data Sheet 31 11.2. Label 31 12. RECOMMENDATIONS 31 12.1. Secondary notification 32 13. BIBLIOGRAPHY 33
TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 5 5.4. Release 6 5.5. Disposal 6 5.6. Public exposure 6 6. PHYSICAL AND CHEMICAL PROPERTIES 6 7. TOXICOLOGICAL INVESTIGATIONS 11 7.1. Acute toxicity – oral 11 7.2. toxicity – dermal 11 7.3. Acute toxicity – inhalation 12 7.4. Irritation – skin 12 7.5. Irritation – eye 12 7.6. Skin sensitisation – mouse local lymph node assay (LLNA) 13 7.7. Repeat dose toxicity - oral 14 7.8. Genotoxicity – bacteria 19 7.9. Genotoxicity – in vitro 19 7.10. Genotoxicity – in vivo 20 8. ENVIRONMENT 21 8.1. Environmental fate 21 8.1.1. biodegradability 21 8.1.2. Bioaccumulation 22 8.2. Ecotoxicological investigations 22 8.2.1. Acute toxicity to fish 22 8.2.2. Acute toxicity to aquatic invertebrates 23 8.2.3. Algal growth inhibition test 24 8.2.4. Inhibition of microbial activity 25 9. RISK ASSESSMENT 26 9.1. Environment 26 9.1.1. Environment – exposure assessment 26 9.1.2. Environment – effects assessment 27 9.1.3. Environment – risk characterisation 27 9.2. Human health 28 9.2.1. Occupational health and safety – exposure assessment 28 9.2.2. Public health – exposure assessment 29 9.2.3. Human health – effects assessment 29 9.2.4. Occupational health and safety – risk characterisation 29 9.2.5. Public health – risk characterisation 30 10. CONCLUSIONS – ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND HUMANS 30 10.1. Hazard classification 30 10.2. Environmental risk assessment 30 10.3. Human health risk assessment 30 10.3.1. Occupational health and safety 30 10.3.2. Public health 30 11. MATERIAL SAFETY DATA SHEET 31 11.1. Material Safety Data Sheet 31 11.2. Label 31 12. RECOMMENDATIONS 31 12.1. Secondary notification 32 13. BIBLIOGRAPHY 33
STD1146FR.docx