Group Number and Sex Dose Mortality of Animals mg/kg bw 1 5/sex 5004 0 LD50 >5004 mg/kg bw Signs of Toxicity None Effects in Organs None Remarks - Results None The analogous chemical is of low toxicity via the oral route. Pharmakon (1997a) 7.2. Acute toxicity dermal – Analogue B OECD TG 402 Acute Dermal Toxicity Limit Test. – EC Directive 92/69/EEC B.3 Acute Toxicity (Dermal) Limit Test. – Species/Strain Rat/Sprague-Dawley Vehicle None Type of dressing Semi-occlusive Remarks - Method No significant protocol deviations Group Number and Sex Dose Mortality of Animals mg/kg bw 1 5/sex 2006 0 LD50 >2006 mg/kg bw Signs of Toxicity - Local None of Toxicity - Systemic One treated female showed low body weight gain, however, this is likely incidental. Effects in Organs None Remarks - Results None The analogous chemical is of low toxicity via the dermal route. Pharmakon (1997b) 7.3. Acute toxicity inhalation – Not performed. 7.4. Irritation skin – Analogue C 0.5 mL of test substance was applied to three clipped, intact areas on the back of each of six rabbits for four hours under occlusive dressings. After exposure, the exposed areas were wiped with mineral oil. Irritation was scored at 1, 24, 48 and 72 hours and 7 and 14 days, using a modified Draize scoring method. Species/Strain Rabbit/New Zealand White Number of Animals 6 Vehicle None Observation Period 14 days Type of Dressing Occlusive Remarks - Method None
Group Number and Sex of Animals Dose mg/kg bw Mortality 1 5/sex 5004 0 LD50 >5004 mg/kg bw Signs of Toxicity None Effects in Organs None Remarks - Results None The analogous chemical is of low toxicity via the oral route. Pharmakon (1997a) 7.2. Acute toxicity – dermal Analogue B OECD TG 402 Acute Dermal Toxicity – Limit Test. EC Directive 92/69/EEC B.3 Acute Toxicity (Dermal) – Limit Test. Species/Strain Rat/Sprague-Dawley Vehicle None Type of dressing Semi-occlusive Remarks - Method No significant protocol deviations Group Number and Sex of Animals Dose mg/kg bw Mortality 1 5/sex 2006 0 LD50 >2006 mg/kg bw Signs of Toxicity - Local None of Toxicity - Systemic One treated female showed low body weight gain, however, this is likely incidental. Effects in Organs None Remarks - Results None The analogous chemical is of low toxicity via the dermal route. Pharmakon (1997b) 7.3. Acute toxicity – inhalation Not performed. 7.4. Irritation – skin Analogue C 0.5 mL of test substance was applied to three clipped, intact areas on the back of each of six rabbits for four hours under occlusive dressings. After exposure, the exposed areas were wiped with mineral oil. Irritation was scored at 1, 24, 48 and 72 hours and 7 and 14 days, using a modified Draize scoring method. Species/Strain Rabbit/New Zealand White Number of Animals 6 Vehicle None Observation Period 14 days Type of Dressing Occlusive Remarks - Method None
STD1198FR.docx