-0.03 (NA, NA) 0.41 rs6449213 -0.04 (NA, NA) 0.19 rs6449213 Other outcomes Kleber ADDIN EN.CITE Genetic risk score of 8 0.95 (0.83, 1.08) 0.41 2015 Germany 3,060/226 Cancer NA OR SUA-related SNPs Keenan ADDIN EN.CITE 71,501/3,151 Genetic risk score of 14 5.84 (4.56,0 7.49) Pakistan 2016 Gout 3.1% OR (2)* SUA-related SNPs NO ADDIN EN.CITE Kleber ADDIN EN.CITE Genetic risk score of 8 1.15 (0.72, 1.82) 0.56 2015 Germany 3,060/19 Gout NA OR SUA-related SNPs 77 79 (discordance in statistical Yang ADDIN significance) EN.CITE 25,982/1,033 Genetic risk score of 8 12.40 (8.50, 18.00) 2010 American Gout 6.0% OR (5)* SUA-related SNPs Abbreviations: MR, Mendelian randomisation study; BMI, body mass index; BMD, bone mineral density; SBP, systolic blood pressure; DBP, diastolic blood pressure; CHD, coronary heart disease; IMT, intima-media thickness; CVD, cardiovascular disease; T2DM, Type 2 diabetes; CKD, chronic kidney disease; SCr, serum creatinine; eGFR, glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C,
rs6449213 -0.03 (NA, NA) 0.41 rs6449213 -0.04 (NA, NA) 0.19 Other outcomes Kleber ADDIN EN.CITE 2015 Germany 3,060/226 Cancer Genetic risk score of 8 SUA-related SNPs NA OR 0.95 (0.83, 1.08) 0.41 Keenan ADDIN EN.CITE 2016 Pakistan 71,501/3,151 (2)* Gout Genetic risk score of 14 SUA-related SNPs 3.1% OR 5.84 (4.56,0 7.49) NO ADDIN EN.CITE 77 79 (discordance in statistical significance) Kleber ADDIN EN.CITE 2015 Germany 3,060/19 Gout Genetic risk score of 8 SUA-related SNPs NA OR 1.15 (0.72, 1.82) 0.56 Yang ADDIN EN.CITE 2010 American 25,982/1,033 (5)* Gout Genetic risk score of 8 SUA-related SNPs 6.0% OR 12.40 (8.50, 18.00) Abbreviations: MR, Mendelian randomisation study; BMI, body mass index; BMD, bone mineral density; SBP, systolic blood pressure; DBP, diastolic blood pressure; CHD, coronary heart disease; IMT, intima-media thickness; CVD, cardiovascular disease; T2DM, Type 2 diabetes; CKD, chronic kidney disease; SCr, serum creatinine; eGFR, glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C,
Supplementary%20material_v7%20-%20Final-2.docx