The C-terminal contains the two conserved histidine α residues (in blue), while the anti-parallel sheet in Nterminal β contains the two conserved cysteine residues. These four residues chelate a zinc ion. EGR family. Early growth response (EGR) family members are immediate early genes coding for transcription factors involved in transmission of various stimuli that initiate cellular responses such as mitosis, cellular differentiation and apoptosis (Swirnoff and Milbrandt 1995). Activation of immediate early genes is very fast, transient and independent of de novo protein synthesis (Lemaire, Revelant et al. 1988; Cao, Koski et al. 1990). Table 2. EGR family members in various vertebrate species. Genes Synonyms Full name Organisms References Nfgi-A growth Rat (Milbrandt 1987) clone A Zif268 Zinc finger clone 268 Mouse (Lemaire, Revelant et al. 1988) Krox-24 Krüppel box 24 (Sukhatme, Cao et al. 1988) Early growth (Suggs, Katzowitz et al. 1990) response 1 egr1 Early growth Zebrafish (Drummond, Rohwer-Nutter response 1 et al. 1994) EGR2 Krox-20 Krüppel box 20 Mouse (Chavrier, Lemaire et al. 1988) EGR2 Early growth Human (Joseph, Le Beau et al. 1988) response 2 Krox-20 Krüppel box 20 Chicken (Nieto, Bradley et al. 1991) Krüppel box 20 Xenopus (Bradley, Snape et al. 1993) Krox-20 krox-20 Krüppel box 20 Zebrafish (Oxtoby and Jowett 1993) Early growth Human (Patwardhan, Gashler et al. EGR3 EGR3 response 3 1991) Egr3 growth response Mouse (Patwardhan, Gashler et al. 3 1991) Egr3 Early growth Rat (Yamagata, Kaufmann et al. response 3 1994) EGR4 Ngfi-C Nerve growth Rat (Crosby, et al. 1991) clone A Egr4 Early growth (Barrow, Simin et al. 1994) response 4 pAT133 Clone pAT133 Human (Muller, Skerka et al. 1991)
The C-terminal α contains the two conserved histidine residues (in blue), while the anti-parallel β sheet in Nterminal contains the two conserved cysteine residues. These four residues chelate a zinc ion. EGR family. Early growth response (EGR) family members are immediate early genes coding for transcription factors involved in transmission of various stimuli that initiate cellular responses such as mitosis, cellular differentiation and apoptosis (Swirnoff and Milbrandt 1995). Activation of immediate early genes is very fast, transient and independent of de novo protein synthesis (Lemaire, Revelant et al. 1988; Cao, Koski et al. 1990). Table 2. EGR family members in various vertebrate species. Genes Synonyms Full name Organisms References Nfgi-A growth clone A Rat (Milbrandt 1987) Zif268 Zinc finger clone 268 Mouse (Lemaire, Revelant et al. 1988) Krox-24 Krüppel box 24 (Sukhatme, Cao et al. 1988) Early growth response 1 (Suggs, Katzowitz et al. 1990) egr1 Early growth response 1 Zebrafish (Drummond, Rohwer-Nutter et al. 1994) EGR2 Krox-20 Krüppel box 20 Mouse (Chavrier, Lemaire et al. 1988) EGR2 Early growth response 2 Human (Joseph, Le Beau et al. 1988) Krox-20 Krüppel box 20 Chicken (Nieto, Bradley et al. 1991) Krox-20 Krüppel box 20 Xenopus (Bradley, Snape et al. 1993) krox-20 Krüppel box 20 Zebrafish (Oxtoby and Jowett 1993) EGR3 EGR3 Early growth response 3 Human (Patwardhan, Gashler et al. 1991) Egr3 growth response 3 Mouse (Patwardhan, Gashler et al. 1991) Egr3 Early growth response 3 Rat (Yamagata, Kaufmann et al. 1994) EGR4 Ngfi-C Nerve growth clone A Rat (Crosby, et al. 1991) Egr4 Early growth response 4 (Barrow, Simin et al. 1994) pAT133 Clone pAT133 Human (Muller, Skerka et al. 1991)
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