Remarks - Method Remarks - Results Tested on the eye mucosa of albino rabbits as an 80% and 60% w/v aqueous solution, the notified chemical did not cause irritation to the washed or unwashed eyes. All scores were zero. The notified chemical is non-irritating to the eye. Chemical industries Inc. (1964b) 7.5.3 Irritation - eye Notified chemical Primary irritation to the eye mucosa of the rabbit was tested and scored in accordance with the procedure outlined in AFDO, US (1959) Species/Strain Rabbit/New Zealand Number of Animals 4F/5M Observation Period 7 days Remarks - Method 0.1 mL instilled into eye- 6 unwashed, 3 washed for 2 seconds with 20 mL water. Concentration (%) Condition of eye in Classification regard to wash after Kay and Calandra Code of Federal No of eyes instillation regulations Positive/No. Tested 100 Unwashed Mildly irritating Negative 0/6 2 second wash Mildly irritating Negative 0/3 Remarks - Results The notified chemical, tested on the eye mucosa of albino rabbits as a 100% w/v aqueous solution, was classified as mildly irritating according to the interpretation of Kay and Calandra. The notified chemical is slightly irritating to the eye. Atlas Chemical industries Inc. (1968) 7.6.1 13-Week repeat dose oral toxicity Notified chemical OECD TG 408 Repeated Dose 90-Day Oral Toxicity Study in Rodents. Species/Strain Rat Sprague Dawley. – Route of Administration Oral gavage/diet/drinking – Exposure Information Total exposure days: 13 weeks Dose regimen: 7 days per week Post-exposure observation period: None Vehicle Water Remarks - Method
Remarks - Method Remarks - Results Tested on the eye mucosa of albino rabbits as an 80% and 60% w/v aqueous solution, the notified chemical did not cause irritation to the washed or unwashed eyes. All scores were zero. The notified chemical is non-irritating to the eye. Chemical industries Inc. (1964b) 7.5.3 Irritation - eye Notified chemical Primary irritation to the eye mucosa of the rabbit was tested and scored in accordance with the procedure outlined in AFDO, US (1959) Species/Strain Rabbit/New Zealand Number of Animals 4F/5M Observation Period 7 days Remarks - Method 0.1 mL instilled into eye- 6 unwashed, 3 washed for 2 seconds with 20 mL water. Concentration (%) Condition of eye in regard to wash after instillation Classification Kay and Calandra Code of Federal regulations No of eyes Positive/No. Tested 100 Unwashed Mildly irritating Negative 0/6 2 second wash Mildly irritating Negative 0/3 Remarks - Results The notified chemical, tested on the eye mucosa of albino rabbits as a 100% w/v aqueous solution, was classified as mildly irritating according to the interpretation of Kay and Calandra. The notified chemical is slightly irritating to the eye. Atlas Chemical industries Inc. (1968) 7.6.1 13-Week repeat dose oral toxicity Notified chemical OECD TG 408 Repeated Dose 90-Day Oral Toxicity Study in Rodents. Species/Strain Rat – Sprague Dawley. Route of Administration Oral – gavage/diet/drinking Exposure Information Total exposure days: 13 weeks Dose regimen: 7 days per week Post-exposure observation period: None Vehicle Water Remarks - Method
STD-1052-FR.docx