Inflammation/ Cellular IL-1 65.81 86.89 141.90 stress (1.8; 295.3) (1.9; 154.6) (1.1; 309.7) TNF-α 150.10 253.70 318.90 (1.2; 384.2) (2.7; 326.9) (15.0; 382.1) NF-κB 46.86 57.27 93.31 (1.1; 192.0) (1.6; 88.6) (1.1; 142.2) ATF4 9.82 12.57 17.12 (1.1; 33.3) (5.4; 17.5) (2.0; 29.5) CHOP 18.03 41.85 60.95 (2.2; 110.3) (1.2; 124.6) (1.6; 97.0) IL-8 85.41 107.90 178.50 (1.6; 240.6) (3.9; 177.3) (70.3; 256.2) Intestinal permeability OCC 45.18 63.11 98.61 and gut barrier (1.4; 280.7) (1.6; 124.4) (5.3; 173.6) function Monocyte F4/80 31.01 42.40 65.06 infiltration/Cell (1.1; 79.0) (2.9; 68.1) (1.2; 98.1) adhesion/Inflammation VCAM1 12.70 21.86 31.38 (3.0; 46.5) (1.5; 29.9) (2.0; 69.7) IL: interleukin; TNF- tumor necrosis factor- NF-κB: nuclear factor kappa B α: α; transcription factor; ATF4: activating transcription factor 4; CHOP: CCAAT/enhancer binding protein homologous protein; OCC: occluding; VCAM1: vascular cell adhesion molecule 1. Data are median (min; max). Outlier detection: GraphPad Prism 6.
Inflammation/ Cellular stress IL-1 65.81 (1.8; 295.3) 86.89 (1.9; 154.6) 141.90 (1.1; 309.7) TNF-α 150.10 (1.2; 384.2) 253.70 (2.7; 326.9) 318.90 (15.0; 382.1) NF-κB 46.86 (1.1; 192.0) 57.27 (1.6; 88.6) 93.31 (1.1; 142.2) ATF4 9.82 (1.1; 33.3) 12.57 (5.4; 17.5) 17.12 (2.0; 29.5) CHOP 18.03 (2.2; 110.3) 41.85 (1.2; 124.6) 60.95 (1.6; 97.0) IL-8 85.41 (1.6; 240.6) 107.90 (3.9; 177.3) 178.50 (70.3; 256.2) Intestinal permeability and gut barrier function OCC 45.18 (1.4; 280.7) 63.11 (1.6; 124.4) 98.61 (5.3; 173.6) Monocyte infiltration/Cell adhesion/Inflammation F4/80 31.01 (1.1; 79.0) 42.40 (2.9; 68.1) 65.06 (1.2; 98.1) VCAM1 12.70 (3.0; 46.5) 21.86 (1.5; 29.9) 31.38 (2.0; 69.7) IL: interleukin; TNF- α: tumor necrosis factor- α; NF-κB: nuclear factor kappa B transcription factor; ATF4: activating transcription factor 4; CHOP: CCAAT/enhancer binding protein homologous protein; OCC: occluding; VCAM1: vascular cell adhesion molecule 1. Data are median (min; max). Outlier detection: GraphPad Prism 6.
Supplementary_Information_NN_10-04-17.docx