Latency will be narrative or meta-analysis (dependent on number of studies for outcome). Subgroup analysis will be performed for tumour grade and type of mouse. Specify (per outcome measure) how it Meta-analysis will only be performed if more than 3 43. will be decided whether a studies provide data for the outcome. analysis will be performed If a meta-analysis seems feasible/sensible, specify (for each outcome measure): All effect The effect measure to be used (e.g. Percentage of biopsies will be risk ratio. measures 44. mean difference, standardized mean if difference, risk ratio, odds ratio) Latency will be mean difference. presented. All statistical methods The statistical model of (e.g. 45. Both random and fixed effects will be considered will be random or fixed effects model) extracted and reported The statistical methods to assess 46. I2 NA heterogeneity (e.g. I2, Q) Which study characteristics will be Subgroup analysis will be performed for tissue type, 47. examined as potential source of NA tumour grade and type of mouse. heterogeneity (subgroup analysis) Any sensitivity analyses you propose No 48. NA to perform Other details meta-analysis (e.g. correction for multiple testing, 49. NA NA correction for multiple use of control group) The method for assessment of Eggers (if more than 10 studies only) 50. NA publication bias Final approval by (names, affiliations): Date:
Latency will be narrative or meta-analysis (dependent on number of studies for outcome). Subgroup analysis will be performed for tumour grade and type of mouse. 43. Specify (per outcome measure) how it will be decided whether a will be performed Meta-analysis will only be performed if more than 3 studies provide data for the outcome. If a meta-analysis seems feasible/sensible, specify (for each outcome measure): 44. The effect measure to be used (e.g. mean difference, standardized mean difference, risk ratio, odds ratio) Percentage of biopsies will be risk ratio. Latency will be mean difference. All effect measures if presented. 45. The statistical model of analysis (e.g. random or fixed effects model) Both random and fixed effects will be considered All statistical methods will be extracted and reported 46. The statistical methods to assess heterogeneity (e.g. I2, Q) I2 NA 47. Which study characteristics will be examined as potential source of heterogeneity (subgroup analysis) Subgroup analysis will be performed for tissue type, tumour grade and type of mouse. NA 48. Any sensitivity analyses you propose to perform No NA 49. Other details meta-analysis (e.g. correction for multiple testing, correction for multiple use of control group) NA NA 50. The method for assessment of publication bias Eggers (if more than 10 studies only) NA Final approval by (names, affiliations): Date:
SYRCLE%3ACAMARADES_protocol_.docx