Biomarker that forecasts Predictive the likely biomarker response to a specific treatment Measurement providing information Clinical on how a endpoint patient feels, functions or survives Measurement providing early and accurate Surrogate prediction of endpoint both a clinical endpoint, and the effects of treatment on this endpoint Confirmation by robust statistical methods that a prognostic biomarker, predictive Validation biomarker or surrogate end point fulfills a set of conditions that are necessary and sufficient for
Predictive biomarker Biomarker that forecasts the likely response to a specific treatment Clinical endpoint Measurement providing information on how a patient feels, functions or survives Surrogate endpoint Measurement providing early and accurate prediction of both a clinical endpoint, and the effects of treatment on this endpoint Validation Confirmation by robust statistical methods that a prognostic biomarker, predictive biomarker or surrogate end point fulfills a set of conditions that are necessary and sufficient for
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