Parallel To test the 110 healthy adults Intervention group Compliance by Randomisation Non-significant Similar GI Chen 2006 effects of (40% male, aged consumed oat daily records and stratified by decreases in total, symptoms soluble from were randomised, bran concentrate returning unused gender and LDL-C and HDL-C reports in both oat-bran on 56 to control group and in muffins and packets. Dietary ethnicity, but oat cholesterol. groups. blood lipids in 54 to intervention. 102 oatmeal cereal to intake by 24hr was older people with completed the study give 7.3g -glucan recall. (3.6 year, normal blood (52 in control, 50 in per day. Control Blood lipids by p=0.03) and had cholesterol intervention) group consumed standard 26% higher concentration. low fibre wheat techniques, baseline dietary muffin and corn calculated. fibre intake. flakes. ITT performed, 2wk run in then comparisons by 12wk intervention. ANOVA and paired t-test. Parallel To test the effect 67 diabetic subjects Soluble oat Compliance by Dietary intakes Non-significant Power Cugnet-Anceau 2010 of enriching a randomised (60% concentrate or returning unused not well changes in total, calculation normal diet with male, aged 30-75, 50% placebo packets, dietary matched. 21% LDL and HDL performed for -glucan on on lipid-lowering consumed in a intake by 5d food participants cholesterol. glucose marker. glucose control medication). soup once a day. intake withdrew, but Thorough and blood lipids 53 completed the trial, 3wk run-in then questionnaire. distribution of assessment, in diabetics. 24 in control, 29 in 8wk intervention. Blood lipids by withdrawals was including blood intervention. standard not reported. analyses, found techniques, LDL no serious calculated. adverse effects. Unpaired t-test or Mann Whitney U test used.
Chen 2006 Parallel To test the effects of soluble from oat-bran on blood lipids in people with normal blood cholesterol concentration. 110 healthy adults (40% male, aged were randomised, 56 to control group and 54 to intervention. 102 completed the study (52 in control, 50 in intervention) Intervention group consumed oat bran concentrate in muffins and oatmeal cereal to give 7.3g -glucan per day. Control group consumed low fibre wheat muffin and corn flakes. 2wk run in then 12wk intervention. Compliance by daily records and returning unused packets. Dietary intake by 24hr recall. Blood lipids by standard techniques, calculated. ITT performed, comparisons by ANOVA and paired t-test. Randomisation stratified by gender and ethnicity, but oat was older (3.6 year, p=0.03) and had 26% higher baseline dietary fibre intake. Non-significant decreases in total, LDL-C and HDL-C cholesterol. Similar GI symptoms reports in both groups. Cugnet-Anceau 2010 Parallel To test the effect of enriching a normal diet with -glucan on glucose control and blood lipids in diabetics. 67 diabetic subjects randomised (60% male, aged 30-75, 50% on lipid-lowering medication). 53 completed the trial, 24 in control, 29 in intervention. Soluble oat concentrate or placebo consumed in a soup once a day. 3wk run-in then 8wk intervention. Compliance by returning unused packets, dietary intake by 5d food intake questionnaire. Blood lipids by standard techniques, LDL calculated. Unpaired t-test or Mann Whitney U test used. Dietary intakes not well matched. 21% participants withdrew, but distribution of withdrawals was not reported. Non-significant changes in total, LDL and HDL cholesterol. Power calculation performed for glucose marker. Thorough assessment, including blood analyses, found no serious adverse effects.
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx