To test the effect 40 mildly Addition of 0, 30, Compliance by Minimised by No significant Leadbetter 1991 of consuming hypercholesterolaemic 60 or 90g per day returning unused design difference on total different subjects (50% male, oat bran to regular sachets. Dietary cholesterol, quantities of oat 25-64y). 2 subjects diet. intake by 5d food or HDL-C. bran on blood withdrew but were 4 x 1mo periods in record before Significant, lipids. replaced. Latin square and 1d food negative design. records during correlation each intervention between oat bran period. Blood amount and lipids measured enzymatically, LDL-C calculated. RMANOVA analysis. To determine if 37 mildly Subjects Compliance by Minimised by Significant Minor GI Lepre 1992 adding oat bran hypercholesterolaemic consumed a low diet review and 4 cross-over decrease in symptoms in to a low subjects (43% male, saturated fat, low x 1 day food design. Small non-significant some subjects saturated fat, 28-69y). 30 completed cholesterol diet, records in last 4 but statistically decrease in (unclear in low cholesterol study. with 2 muffins per of study. significant cholesterol. which diet had day containing Dietary intake by differences in intervention) additional either 60g oat 4 x 1 day weighed some nutrient bran (3.2g soluble food records (1 intakes between effects. or 60g wheat day/week for last intervention bran. four weeks of periods. 3x 8wk periods each period). (diet only, oat Blood lipids muffin or wheat measured, LDL-C muffin) calculated. Statistical analysis by variance and
Leadbetter 1991 To test the effect of consuming different quantities of oat bran on blood lipids. 40 mildly hypercholesterolaemic subjects (50% male, 25-64y). 2 subjects withdrew but were replaced. Addition of 0, 30, 60 or 90g per day oat bran to regular diet. 4 x 1mo periods in Latin square design. Compliance by returning unused sachets. Dietary intake by 5d food record before and 1d food records during each intervention period. Blood lipids measured enzymatically, LDL-C calculated. RMANOVA analysis. Minimised by design No significant difference on total cholesterol, or HDL-C. Significant, negative correlation between oat bran amount and Lepre 1992 To determine if adding oat bran to a low saturated fat, low cholesterol diet had additional effects. 37 mildly hypercholesterolaemic subjects (43% male, 28-69y). 30 completed study. Subjects consumed a low saturated fat, low cholesterol diet, with 2 muffins per day containing either 60g oat bran (3.2g soluble or 60g wheat bran. 3x 8wk periods (diet only, oat muffin or wheat muffin) Compliance by diet review and 4 x 1 day food records in last 4 of study. Dietary intake by 4 x 1 day weighed food records (1 day/week for last four weeks of each period). Blood lipids measured, LDL-C calculated. Statistical analysis by variance and Minimised by cross-over design. Small but statistically significant differences in some nutrient intakes between intervention periods. Significant decrease in non-significant decrease in cholesterol. Minor GI symptoms in some subjects (unclear in which intervention)
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