Did the reaction reappear when a placebo was given? Yes (-1) No (+1) Do not know/Not measured/Not done (0) Was the drug detected in any body fluid in toxic concentrations? Yes (+1) No (0) Do not know/Not measured/Not done (0) Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? Yes (+1) No (0) Do not know/Not measured/Not done (0) Did the patient have a similar reaction to the same or similar drugs in any previous exposure? Yes (+1) No (0) Do not know/Not measured/Not done (0) Was the adverse event confirmed by any objective evidence? Yes (+1) No (0) Do not know/Not measured/Not done (0). Abnormalities on EEG were not counted as objective evidence because of lack of specificity. Supplement e-References: List of references of case reports/series 1. Abanades S, Nolla J, Rodríguez-Campello A, Pedro C, Valls A, Farré M. Reversible coma secondary to cefepime neurotoxicity. Ann Pharmacother. 2004;38(4):606–608. 2. Abba-Aji A, Mulligan O. Psychosis? Beware - case series of clarithromycin and psychosis. Irish Journal of Psychological Medicine. 2007;24(02):79–80. 3. Abbas MT, Khan FY, Sulimon S, Baidaa A. Encephalopathy secondary to isoniazid in
Did the reaction reappear when a placebo was given? Yes (-1) No (+1) Do not know/Not measured/Not done (0) Was the drug detected in any body fluid in toxic concentrations? Yes (+1) No (0) Do not know/Not measured/Not done (0) Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? Yes (+1) No (0) Do not know/Not measured/Not done (0) Did the patient have a similar reaction to the same or similar drugs in any previous exposure? Yes (+1) No (0) Do not know/Not measured/Not done (0) Was the adverse event confirmed by any objective evidence? Yes (+1) No (0) Do not know/Not measured/Not done (0). Abnormalities on EEG were not counted as objective evidence because of lack of specificity. Supplement e-References: List of references of case reports/series 1. Abanades S, Nolla J, Rodríguez-Campello A, Pedro C, Valls A, Farré M. Reversible coma secondary to cefepime neurotoxicity. Ann Pharmacother. 2004;38(4):606–608. 2. Abba-Aji A, Mulligan O. Psychosis? Beware - case series of clarithromycin and psychosis. Irish Journal of Psychological Medicine. 2007;24(02):79–80. 3. Abbas MT, Khan FY, Sulimon S, Baidaa A. Encephalopathy secondary to isoniazid in
Supplemental_data.docx