TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure assessment 7 6.1.1. Occupational exposure 7 6.1.2. Public exposure 8 6.2. Human health effects assessment 8 6.3. Human health risk characterisation 9 6.3.1. Occupational health and safety 9 6.3.2. Public health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1 Environmental Exposure 10 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 11 7.2. Environmental effects assessment 11 7.2.1 Predicted No-Effect Concentration 11 7.3. Environmental risk assessment 12 8. CONCLUSIONS SUMMARY OF RISK ASSESSMENT FOR THE ENVIRONMENT AND – HUMAN HEALTH 12 8.1. Hazard classification 12 8.2. Environmental risk assessment 12 8.3. Human health risk assessment 12 8.3.1. Occupational health and safety 12 8.3.2. Public health 12 9. MATERIAL SAFETY DATA SHEET 12 10. RECOMMENDATIONS 13 11. REGULATORY OBLIGATIONS 13 12 . BIBLIOGRAPHY 14 Appendix A: Physico-Chemical Properties 17 Appendix B: Toxicological Investigations 20 B.1. Acute toxicity oral 20 – B.2. toxicity dermal 20 – B.3. Acute toxicity inhalation 20 – B.4. Irritation skin 21 – B.5. Irritation eye 21 – B.6. Skin sensitisation 22 B.7. Repeat dose toxicity 22 B.8. Genotoxicity bacteria 24 – B.9. Genotoxicity in vitro 25 – B.10. Neurotoxicity 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C.1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.1.2. Bioaccumulation 27 C.1.3. Chemical oxygen demand (COD) 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute/chronic toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 31
TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure assessment 7 6.1.1. Occupational exposure 7 6.1.2. Public exposure 8 6.2. Human health effects assessment 8 6.3. Human health risk characterisation 9 6.3.1. Occupational health and safety 9 6.3.2. Public health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1 Environmental Exposure 10 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 11 7.2. Environmental effects assessment 11 7.2.1 Predicted No-Effect Concentration 11 7.3. Environmental risk assessment 12 8. CONCLUSIONS – SUMMARY OF RISK ASSESSMENT FOR THE ENVIRONMENT AND HUMAN HEALTH 12 8.1. Hazard classification 12 8.2. Environmental risk assessment 12 8.3. Human health risk assessment 12 8.3.1. Occupational health and safety 12 8.3.2. Public health 12 9. MATERIAL SAFETY DATA SHEET 12 10. RECOMMENDATIONS 13 11. REGULATORY OBLIGATIONS 13 12 . BIBLIOGRAPHY 14 Appendix A: Physico-Chemical Properties 17 Appendix B: Toxicological Investigations 20 B.1. Acute toxicity – oral 20 B.2. toxicity – dermal 20 B.3. Acute toxicity – inhalation 20 B.4. Irritation – skin 21 B.5. Irritation – eye 21 B.6. Skin sensitisation 22 B.7. Repeat dose toxicity 22 B.8. Genotoxicity – bacteria 24 B.9. Genotoxicity – in vitro 25 B.10. Neurotoxicity 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C.1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.1.2. Bioaccumulation 27 C.1.3. Chemical oxygen demand (COD) 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute/chronic toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 31
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