method unclear Van Horn ? Stratified by ? Not described high Not blinded ? Not stated high 28% low Expected low gender and attrition outcomes 1991 total chol., reported method unclear ? Method not ? Not described low Participants ? Not stated low No attrition low Expected low stated blinded outcomes Vorster 1986 reported 1992 ? Method not ? Not described ? Not stated ? Not stated low 4% low Expected low stated attrition outcomes reported Wolever low Computer low Sequentially low Double low Blinded low 6% low Expected low generated numbered blind attrition, outcomes 2010 opaque reported envelopes analysis performed Zhang 2012 ? Method not ? Not described high Not blinded low Statistician low 9% low Expected low stated blinded attrition outcomes reported ?, indicates unclear risk of bias Appendix 6 GRADE summary of findings table for – β-glucan Question: What is the food-health relationship between pure and blood cholesterol concentration? β-glucan Effect Quality assessment of body of evidence Participants Quality estimate (degree of Number Mean certainty in Risk of of Design Inconsistency Indirectness Imprecision Considerations difference relationship) bias studies (95% CI) Change in total cholesterol Not Not Not applicable 0 Not applicable 0 0 0 applicable applicable Change in LDL cholesterol Not Not Not applicable 0 Not applicable 0 0 0 applicable applicable
method unclear Van Horn 1991 ? Stratified by gender and total chol., method unclear ? Not described high Not blinded ? Not stated high 28% attrition low Expected outcomes reported low Vorster 1986 ? Method not stated ? Not described low Participants blinded ? Not stated low No attrition low Expected outcomes reported low 1992 ? Method not stated ? Not described ? Not stated ? Not stated low 4% attrition low Expected outcomes reported low Wolever 2010 low Computer generated low Sequentially numbered opaque envelopes low Double blind low Blinded low 6% attrition, analysis performed low Expected outcomes reported low Zhang 2012 ? Method not stated ? Not described high Not blinded low Statistician blinded low 9% attrition low Expected outcomes reported low ?, indicates unclear risk of bias Appendix 6 – GRADE summary of findings table for β-glucan Question: What is the food-health relationship between pure β-glucan and blood cholesterol concentration? Quality assessment of body of evidence Participants Effect estimate Quality (degree of certainty in relationship) Number of studies Design Risk of bias Inconsistency Indirectness Imprecision Considerations Mean difference (95% CI) Change in total cholesterol 0 Not applicable Not applicable Not applicable Not applicable 0 0 0 Change in LDL cholesterol 0 Not applicable Not applicable Not applicable Not applicable 0 0 0
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx