Parallel To test the effect 51 mildly Oat bran and oat Compliance by Groups No significant Power Kerckhoffs 2003 of -glucan from hypercholesterolaemic bran concentrate recording daily at changes in lipid calculation oat bran in adults (44% male, administered in intake of test baseline. profile. No effect performed for goods on serum 48 completed bread and cookies foods. Dietary of gender. LDL-C. lipids and study. to give daily intake intakes by FFQ. lipoproteins. 5.9g -glucan. Blood lipids Subgroup analysis measured performed for enzymatically, gender. 3wk LDL-C calculated. 4wk ANOVA and t-test intervention. analysis, gender subgroup analysis. Kestin 1990 To test the effect 28 mildly Low fibre diet Compliance by Minimised by Significant of different hypercholesterolaemic supplemented food intake diary cross-over decrease in cereal brans on men (aged 29-61). 24 with bread and and weighed food design and LDL-C. blood lipids and completed study. muffins made with records. Dietary lipoproteins as oat, wheat or rice intake by 4d difference in well as bran. Wheat bran weighed food and TG. measures of selected as records in each glucose and control group. Oat period. insulin and stool group consumed Blood lipids frequency. 95g containing measured using 5.8g of water automated soluble fibre. 3wk methods, LDL-C low fibre run-in calculated. then 3x 4wk ANOVA and t-test intervention analysis. periods.
Kerckhoffs 2003 Parallel To test the effect of -glucan from oat bran in goods on serum lipids and lipoproteins. 51 mildly hypercholesterolaemic adults (44% male, 48 completed study. Oat bran and oat bran concentrate administered in bread and cookies to give daily intake 5.9g -glucan. Subgroup analysis performed for gender. 3wk 4wk intervention. Compliance by recording daily intake of test foods. Dietary intakes by FFQ. Blood lipids measured enzymatically, LDL-C calculated. ANOVA and t-test analysis, gender subgroup analysis. Groups at baseline. No significant changes in lipid profile. No effect of gender. Power calculation performed for LDL-C. Kestin 1990 To test the effect of different cereal brans on blood lipids and lipoproteins as well as measures of glucose and insulin and stool frequency. 28 mildly hypercholesterolaemic men (aged 29-61). 24 completed study. Low fibre diet supplemented with bread and muffins made with oat, wheat or rice bran. Wheat bran selected as control group. Oat group consumed 95g containing 5.8g of water soluble fibre. 3wk low fibre run-in then 3x 4wk intervention periods. Compliance by food intake diary and weighed food records. Dietary intake by 4d weighed food records in each period. Blood lipids measured using automated methods, LDL-C calculated. ANOVA and t-test analysis. Minimised by cross-over design Significant decrease in and LDL-C. difference in and TG.
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