major sensorineural disability at Proportion of infants with sensorineural sensorineural method of therapeutic therefore not included. Benefit is primarily due to decreased 2 years of age. Adverse effects indicators of peripartum impairment at 2 impairment at 2 hypothermia is effective mortality. of hypothermia are negligible. and moderate to years. years. and safe. No impairment in survivors, standard life expectancy. severe clinical encephalopathy (1.2 per 1000) N= 369 Outcome Difference in N if Health service Economic QALY Economic impact on Total Economic Impact risk between implemented at cost per person Impact on impact per QALYS if control and 65% or day health service person implemented treatment costs if implemented Primary Composite outcome – - - - - - - - individually costed below. Secondary Mortality -35% -32 - - -$4.2m -$136m -$136m No statistically Sensorineural significant - - - - - - impairment difference. Change in +<$0.1m intervention costs - Totals -$136m -$136m Columns may not sum due to rounding. Negative values are savings in the calculations. Health service/ Health Service outcome cost per Explanation and costing assumptions Reference or Outcome person or day Incremental gain is extra survivors, who are not impaired or disabled. Office of Best Practice Regulation, value of statistical life year. Survivors have full life expectancy. QALY: Mortality -$4,200,000 Confirmed through interview.
major sensorineural disability at 2 years of age. Adverse effects of hypothermia are negligible. sensorineural impairment at 2 years. sensorineural impairment at 2 years. method of therapeutic hypothermia is effective and safe. therefore not included. Benefit is primarily due to decreased mortality. No impairment in survivors, standard life expectancy. Proportion of infants with indicators of peripartum and moderate to severe clinical encephalopathy (1.2 per 1000) N= 369 Outcome Difference in risk between control and treatment N if implemented at 65% Health service cost per person or day Economic Impact on health service costs if implemented QALY impact per person Economic impact on QALYS if implemented Total Economic Impact Primary Composite outcome – individually costed below. - - - - - - - Secondary Mortality -35% -32 - - -$4.2m -$136m -$136m Sensorineural impairment No statistically significant difference. - - - - - - Change in intervention costs Totals +<$0.1m - -$136m -$136m Columns may not sum due to rounding. Negative values are savings in the calculations. Health Service or Outcome Health service/ outcome cost per person or day Explanation and costing assumptions Reference Mortality QALY: -$4,200,000 Incremental gain is extra survivors, who are not impaired or disabled. Survivors have full life expectancy. Confirmed through interview. Office of Best Practice Regulation, value of statistical life year.
Supplementary-Appendix-B-Economic-evaluation-of-investigator-initiated-clinical-trials-conducted-by-networks.docx