OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 4 5.4. Release 5 5.5. Disposal 5 5.6. Public exposure 5 6. PHYSICAL AND CHEMICAL PROPERTIES 6 6.1 Comments on physico-chemical properties 9 7. TOXICOLOGICAL INVESTIGATIONS 9 7.1. toxicity oral 9 – 7.2. toxicity dermal 10 – 7.3. Acute toxicity inhalation 10 – 7.4. Irritation skin 10 – 7.5. Irritation eye 11 – 7.6. Skin sensitisation 12 7.7. 28-day repeat dose oral toxicity 13 7.8. Genotoxicity bacteria 15 – 7.9. Genotoxicity in vitro 15 – 7.10. Genotoxicity in vivo 16 – 8. ENVIRONMENT 18 8.1. Environmental fate 18 8.1.1. Ready biodegradability 18 8.1.2. Bioaccumulation 18 8.2. Ecotoxicological investigations 18 8.2.1. Acute toxicity to fish 18 8.2.2. Acute toxicity to aquatic invertebrates 19 8.2.3. Algal growth inhibition test 20 8.2.4. Inhibition of microbial activity 20 9. RISK ASSESSMENT 22 9.1. Environment 22 9.1.1. Environment exposure assessment 22 – 9.1.2. Environment effects assessment 22 – 9.1.3. Environment risk characterisation 22 – 9.2. health 23 9.2.1. Occupational health and safety exposure assessment 23 – 9.2.2. Public health exposure assessment 23 – 9.2.3. Human health effects assessment 23 – 9.2.4. Occupational health and safety risk characterisation 24 – 9.2.5. Public health risk characterisation 24 – 10. CONCLUSIONS ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND – HUMANS 25 10.1. Hazard classification 25 10.2. Environmental risk assessment 25 10.3. Human health risk assessment 25 10.3.1. Occupational health and safety 25 10.3.2. Public health 25 11. MATERIAL SAFETY DATA SHEET 25 11.1. Material Safety Data Sheet 25 11.2. Label 25 12. RECOMMENDATIONS 26 12.1. Secondary notification 27 13. BIBLIOGRAPHY 27
OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 4 5.4. Release 5 5.5. Disposal 5 5.6. Public exposure 5 6. PHYSICAL AND CHEMICAL PROPERTIES 6 6.1 Comments on physico-chemical properties 9 7. TOXICOLOGICAL INVESTIGATIONS 9 7.1. toxicity – oral 9 7.2. toxicity – dermal 10 7.3. Acute toxicity – inhalation 10 7.4. Irritation – skin 10 7.5. Irritation – eye 11 7.6. Skin sensitisation 12 7.7. 28-day repeat dose oral toxicity 13 7.8. Genotoxicity – bacteria 15 7.9. Genotoxicity – in vitro 15 7.10. Genotoxicity – in vivo 16 8. ENVIRONMENT 18 8.1. Environmental fate 18 8.1.1. Ready biodegradability 18 8.1.2. Bioaccumulation 18 8.2. Ecotoxicological investigations 18 8.2.1. Acute toxicity to fish 18 8.2.2. Acute toxicity to aquatic invertebrates 19 8.2.3. Algal growth inhibition test 20 8.2.4. Inhibition of microbial activity 20 9. RISK ASSESSMENT 22 9.1. Environment 22 9.1.1. Environment – exposure assessment 22 9.1.2. Environment – effects assessment 22 9.1.3. Environment – risk characterisation 22 9.2. health 23 9.2.1. Occupational health and safety – exposure assessment 23 9.2.2. Public health – exposure assessment 23 9.2.3. Human health – effects assessment 23 9.2.4. Occupational health and safety – risk characterisation 24 9.2.5. Public health – risk characterisation 24 10. CONCLUSIONS – ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND HUMANS 25 10.1. Hazard classification 25 10.2. Environmental risk assessment 25 10.3. Human health risk assessment 25 10.3.1. Occupational health and safety 25 10.3.2. Public health 25 11. MATERIAL SAFETY DATA SHEET 25 11.1. Material Safety Data Sheet 25 11.2. Label 25 12. RECOMMENDATIONS 26 12.1. Secondary notification 27 13. BIBLIOGRAPHY 27
STD-1060-FR.docx