Supplementary table S2 General characteristics and main findings of the systematic reviews of observational studies Author Year Population Study design Comparison Outcome N studies Authors' interpretation Cardiovascular Outcomes Baker1 2005 Healthy subjects Cohort SUA level CVD 10 The excess risk associated with SUA in healthy patients is likely to be small. High SUA is likely an independent risk factor in patients at high CVD risk. Patients at high CVD Baker1 2005 Cohort SUA level CVD 11 risk Strazzullo2 2007 General Cohort SUA level CVD 16 Patients with arterial SUA is a very weak predictor of CVD in healthy population, but a Strazzullo2 2007 Cohort SUA level CVD 8 hypertension significant independent predictor among subjects at high or very high risk. Patients at high CVD Strazzullo2 2007 Cohort SUA level CVD 5 risk Barron ADDIN EN.CITE Greater risk of CVD/all-cause mortality in those with the highest than with 2015 General Cohort SUA level CVD 3 the lowest quartiles of SUA. It remains controversial whether elevated serum uric acid is neuroprotective Dimitroula4 2008 General Cohort SUA level Stroke 13 or injurious at the onset of acute stroke. Hwu5 2010 General SUA level Hypertension 6 All except one study have documented a direct association with either incident hypertension or increase in blood pressure. Hyper vs Hwu5 2010 General Hypertension 17 control normal Kidney disease
Supplementary table S2 General characteristics and main findings of the systematic reviews of observational studies Author Year Population Study design Comparison Outcome N studies Authors' interpretation Cardiovascular Outcomes Baker1 2005 Healthy subjects Cohort SUA level CVD 10 The excess risk associated with SUA in healthy patients is likely to be small. High SUA is likely an independent risk factor in patients at high CVD risk. Baker1 2005 Patients at high CVD risk Cohort SUA level CVD 11 Strazzullo2 2007 General Cohort SUA level CVD 16 SUA is a very weak predictor of CVD in healthy population, but a significant independent predictor among subjects at high or very high risk. Strazzullo2 2007 Patients with arterial hypertension Cohort SUA level CVD 8 Strazzullo2 2007 Patients at high CVD risk Cohort SUA level CVD 5 Barron ADDIN EN.CITE 2015 General Cohort SUA level CVD 3 Greater risk of CVD/all-cause mortality in those with the highest than with the lowest quartiles of SUA. Dimitroula4 2008 General Cohort SUA level Stroke 13 It remains controversial whether elevated serum uric acid is neuroprotective or injurious at the onset of acute stroke. Hwu5 2010 General SUA level Hypertension 6 All except one study have documented a direct association with either incident hypertension or increase in blood pressure. Hwu5 2010 General Hyper vs normal Hypertension 17 Kidney disease control
Supplementary%20material_v7%20-%20Final-2.docx