Summary of outcomes of IRT analysis (A) Absolute TSCR and (B) Relative TSCR to a sternal reference region. A Absolute TSCR (°C) Vehicle session Cold Session p-value Base TSCR 35.7±0.07 35.1±0.29 0.09 Peak TSCR (initial) 35.8±0.06 35.2±0.29 0.09 0.1±0.03 0.1±0.03 0.64 Δ10TSCR Peak TSCR (initial & final) 35.9±0.08 35.4±0.25 0.06 TSCR at 10mins of cooling 35.6±0.07 35.1±0.30 0.11 TSCR in final minute of 35.7±0.08 35.3±0.25 0.09 cooling B TSCR relative to sternal reference region (°C) Vehicle session Cold Session p-value Base TSCR 1.3±0.13 1.9± 0.24 0.01 Peak TSCR (initial) 1.4±0.13 2.2±0.27 0.01 0.2±0.03 0.3±0.05 0.04 Δ10TSCR Peak TSCR (initial & final) 1.5±0.14 2.7±0.29 0.001 TSCR at 10mins of cooling 1.4±0.14 2.2±0.26 0.004 1.4±0.13 2.6±0.27 0.0004 TSCR in final minute of cooling Means (± SEM) from 8 adult males. TSCR: supraclavicular temperature; change in TSCR (peak TSCR base TSCR) over the first 10 minutes of Δ10TSCR: – cooling Table Percentage spatial overlap between MIP and TI Individual values from 8 adult males showing the percentage spatial overlap between the area of maximum supraclavicular MR(gluc) on the MR(gluc)MIP image and the area of maximum supraclavicular temperature on the TI. Overlap for participants who underwent both cold and vehicle PET-CT scans was significantly reduced in the vehicle sessions (cold: 35.4±5.1%, vehicle: 4.7±2.8%, p < 0.001). Overlap (%) Cold Vehicle
Summary of outcomes of IRT analysis (A) Absolute TSCR and (B) Relative TSCR to a sternal reference region. A Absolute TSCR (°C) Vehicle session Cold Session p-value Base TSCR 35.7±0.07 35.1±0.29 0.09 Peak TSCR (initial) 35.8±0.06 35.2±0.29 0.09 Δ10TSCR 0.1±0.03 0.1±0.03 0.64 Peak TSCR (initial & final) 35.9±0.08 35.4±0.25 0.06 TSCR at 10mins of cooling 35.6±0.07 35.1±0.30 0.11 TSCR in final minute of cooling 35.7±0.08 35.3±0.25 0.09 B TSCR relative to sternal reference region (°C) Vehicle session Cold Session p-value Base TSCR 1.3±0.13 1.9± 0.24 0.01 Peak TSCR (initial) 1.4±0.13 2.2±0.27 0.01 Δ10TSCR 0.2±0.03 0.3±0.05 0.04 Peak TSCR (initial & final) 1.5±0.14 2.7±0.29 0.001 TSCR at 10mins of cooling 1.4±0.14 2.2±0.26 0.004 TSCR in final minute of cooling 1.4±0.13 2.6±0.27 0.0004 Means (± SEM) from 8 adult males. TSCR: supraclavicular temperature; Δ10TSCR: change in TSCR (peak TSCR – base TSCR) over the first 10 minutes of cooling Table Percentage spatial overlap between MIP and TI Individual values from 8 adult males showing the percentage spatial overlap between the area of maximum supraclavicular MR(gluc) on the MR(gluc)MIP image and the area of maximum supraclavicular temperature on the TI. Overlap for participants who underwent both cold and vehicle PET-CT scans was significantly reduced in the vehicle sessions (cold: 35.4±5.1%, vehicle: 4.7±2.8%, p < 0.001). Overlap (%) Cold Vehicle
Thermal%20imaging%20is%20a%20non-invasive%20alternative%20to%20PET-CT%20for%20measurement%20of%20BAT%20activity%20in%20humans%20-%20accepted%20version.docx