Acute oral toxicity (calcium/sodium Rat LD50 >5.0 g/kg SEAC Toxicology Group, salt) 1979b Acute oral toxicity (free acid) Mice LD50 4.1 g/kg SEAC Toxicology Group, 1976 Acute oral toxicity (free acid) Rats LD50 4.1 g/kg SEAC Toxicology Group, 1977a intraperitoneal toxicity (free Mice LD50 0.30 g/kg SEAC Toxicology Group, acid) 1977b percutaneous toxicity (free Rabbits Non-toxic by skin Younger Laboratories, acid) absorption 1968a Skin irritation intradermal Rabbit – Slight to moderate SEAC Toxicology injection test (notified chemical) 1980a Skin irritation covered test Rabbit – Slight irritant SEAC Toxicology Group, (notified chemical) 1980b Skin irritation (intradermal injection Rabbit Slight to moderate SEAC Toxicology Group, test; Komplex ) 1980c Skin irritation (intradermal injection Rabbit Slight to moderate SEAC Toxicology Group, test, Calcium analogue Draise – 1980d Product) Skin irritation covered patch test Rabbit – Slight to moderate SEAC Toxicology Group, (free acid) 1977c Skin irritation - intradermal Rabbits Slight to moderate SEAC Toxicology injection test (free acid) 1977d Eye irritation (notified chemical) Rabbit Slight irritant SEAC Toxicology Group, 1980e Eye irritation (free acid) Rabbit Moderate Younger Laboratories, 1968b Skin sensitisation (notified Guinea pig Non-sensitiser SEAC Toxicology Group, chemical) 1981a Skin sensitisation (notified Guinea pig Sensitiser SEAC Toxicology Group, chemical) 1983 Skin sensitisation (notified Guinea pig Weak sensitiser SEAC Toxicology Group, chemical) 1982 Skin sensitisation (calcium/sodium Guinea pig Weak-sensitiser SEAC Toxicology Group, salt) 1981b Skin sensitisation (calcium sodium Guinea pig Non-sensitiser SEAC Toxicology Group, salt) 1984 Skin sensitisation (free acid) Guinea pig Non-sensitiser SEAC Toxicology Group, 1977e Oral Toxicity Oral toxicity of the calcium/sodium salt (SEAC toxicology Group, 1979a) Mice (strain not specified) Species/strain: 3/sex/group Number/sex of animals: 21 days Observation period:
Acute oral toxicity (calcium/sodium salt) Rat LD50 >5.0 g/kg SEAC Toxicology Group, 1979b Acute oral toxicity (free acid) Mice LD50 4.1 g/kg SEAC Toxicology Group, 1976 Acute oral toxicity (free acid) Rats LD50 4.1 g/kg SEAC Toxicology Group, 1977a intraperitoneal toxicity (free acid) Mice LD50 0.30 g/kg SEAC Toxicology Group, 1977b percutaneous toxicity (free acid) Rabbits Non-toxic by skin absorption Younger Laboratories, 1968a Skin irritation – intradermal injection test (notified chemical) Rabbit Slight to moderate SEAC Toxicology 1980a Skin irritation – covered test (notified chemical) Rabbit Slight irritant SEAC Toxicology Group, 1980b Skin irritation (intradermal injection test; Komplex ) Rabbit Slight to moderate SEAC Toxicology Group, 1980c Skin irritation (intradermal injection test, Calcium analogue – Draise Product) Rabbit Slight to moderate SEAC Toxicology Group, 1980d Skin irritation – covered patch test (free acid) Rabbit Slight to moderate SEAC Toxicology Group, 1977c Skin irritation - intradermal injection test (free acid) Rabbits Slight to moderate SEAC Toxicology 1977d Eye irritation (notified chemical) Rabbit Slight irritant SEAC Toxicology Group, 1980e Eye irritation (free acid) Rabbit Moderate Younger Laboratories, 1968b Skin sensitisation (notified chemical) Guinea pig Non-sensitiser SEAC Toxicology Group, 1981a Skin sensitisation (notified chemical) Guinea pig Sensitiser SEAC Toxicology Group, 1983 Skin sensitisation (notified chemical) Guinea pig Weak sensitiser SEAC Toxicology Group, 1982 Skin sensitisation (calcium/sodium salt) Guinea pig Weak-sensitiser SEAC Toxicology Group, 1981b Skin sensitisation (calcium sodium salt) Guinea pig Non-sensitiser SEAC Toxicology Group, 1984 Skin sensitisation (free acid) Guinea pig Non-sensitiser SEAC Toxicology Group, 1977e Oral Toxicity Oral toxicity of the calcium/sodium salt (SEAC toxicology Group, 1979a) Species/strain: Mice (strain not specified) Number/sex of animals: 3/sex/group Observation period: 21 days
STD1016FR.docx