Supplementary Figure Figure S1. Expression analysis of and in NSCLC, SCLC, and FAIM2, FADD, FAS, CASP8 133 NSCLC, 54 SCLC, and 17 neuroblastoma (NB) cell lines neuroblastoma (NB) cell lines. from CCLE database () were analyzed. mRNA expression was significantly higher in NB FAIM2 cells compared to those in NSCLC cells (p = 0.0015). In contrast, three proapoptotic genes, FAS, and showed higher expression in NSCLC compared to those NB cells (p < FADD, CASP8 0.0001 for and These data suggest tumor cells (SCLC and NB) with FADD, FAS, CASP8). neuroendocrine origin commonly have a suppressed Fas apoptosis signaling pathway and overexpression of the anti-apoptotic gene FAIM2.
Supplementary Figure Figure S1. Expression analysis of FAIM2, FADD, FAS, and CASP8 in NSCLC, SCLC, and neuroblastoma (NB) cell lines. 133 NSCLC, 54 SCLC, and 17 neuroblastoma (NB) cell lines from CCLE database () were analyzed. FAIM2 mRNA expression was significantly higher in NB cells compared to those in NSCLC cells (p = 0.0015). In contrast, three proapoptotic genes, FAS, FADD, and CASP8 showed higher expression in NSCLC compared to those NB cells (p < 0.0001 for FADD, FAS, and CASP8). These data suggest tumor cells (SCLC and NB) with neuroendocrine origin commonly have a suppressed Fas apoptosis signaling pathway and overexpression of the anti-apoptotic gene FAIM2.
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