TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 3 4. PHYSICAL AND CHEMICAL PROPERTIES 4 Discussion of Observed Effects 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1. Exposure assessment 5 6.1.1. Occupational exposure 5 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1 Environmental Exposure 9 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 10 7.2. Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3. Environmental risk assessment 11 8. CONCLUSIONS SUMMARY OF RISK ASSESSMENT FOR THE ENVIRONMENT AND – HUMAN HEALTH 11 8.1. Hazard classification 11 8.2. health risk assessment 11 8.2.1. Occupational health and safety 11 8.2.2. Public health 11 8.3. Environmental risk assessment 11 9. MATERIAL SAFETY DATA SHEET 12 10. RECOMMENDATIONS 12 11. REGULATORY OBLIGATIONS 12 12 . BIBLIOGRAPHY 13 Appendix A: Physico-Chemical Properties 16 Appendix B: Toxicological Investigations 19 B.1. Acute toxicity oral 19 – B.2. Acute toxicity dermal 19 – B.3. Irritation skin 19 – B.4. Irritation eye 20 – B.5. Skin sensitisation 20 B.6. Repeat dose toxicity (14 day) 21 B.7. Repeat dose toxicity (28 day) 22 B.8. Genotoxicity bacteria 23 – B.9. Genotoxicity 25 – in vitro B.10. Genotoxicity 25 in vivo – Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.1.2. Bioaccumulation 27 C2. Ecotoxicological Investigations 27 C.2.1. Acute toxicity to fish 27 C.2.2. toxicity to aquatic invertebrates 28 C.2.3. Algal growth inhibition test 29 C.2.4. Inhibition of microbial activity 30
TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 3 4. PHYSICAL AND CHEMICAL PROPERTIES 4 Discussion of Observed Effects 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1. Exposure assessment 5 6.1.1. Occupational exposure 5 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1 Environmental Exposure 9 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 10 7.2. Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3. Environmental risk assessment 11 8. CONCLUSIONS – SUMMARY OF RISK ASSESSMENT FOR THE ENVIRONMENT AND HUMAN HEALTH 11 8.1. Hazard classification 11 8.2. health risk assessment 11 8.2.1. Occupational health and safety 11 8.2.2. Public health 11 8.3. Environmental risk assessment 11 9. MATERIAL SAFETY DATA SHEET 12 10. RECOMMENDATIONS 12 11. REGULATORY OBLIGATIONS 12 12 . BIBLIOGRAPHY 13 Appendix A: Physico-Chemical Properties 16 Appendix B: Toxicological Investigations 19 B.1. Acute toxicity – oral 19 B.2. Acute toxicity – dermal 19 B.3. Irritation – skin 19 B.4. Irritation – eye 20 B.5. Skin sensitisation 20 B.6. Repeat dose toxicity (14 day) 21 B.7. Repeat dose toxicity (28 day) 22 B.8. Genotoxicity – bacteria 23 B.9. Genotoxicity – in vitro 25 B.10. Genotoxicity – in vivo 25 Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.1.2. Bioaccumulation 27 C2. Ecotoxicological Investigations 27 C.2.1. Acute toxicity to fish 27 C.2.2. toxicity to aquatic invertebrates 28 C.2.3. Algal growth inhibition test 29 C.2.4. Inhibition of microbial activity 30
STD1242FR.docx