Rat, harmful inhalation LC50 < 5.1 mg/L/1 hour Rabbit, skin slightly irritation (3 irritating studies) Rabbit, skin moderately irritation irritating (based on 24 hour exposure) Rabbit, eye slightly irritation (4 irritating studies) Guinea pig, skin limited sensitisation evidence of – adjuvant test. Guinea pig, skin no sensitisation evidence of – adjuvant test (2 studies) Rat, repeat NOEL = 500 mg/kg toxicity 91 bw/day – days. Genotoxicity non – bacterial reverse mutagenic mutation Genotoxicity in non – vitro chromosomal genotoxic aberrations in human lymphocytes Genotoxicity in equivocal – vitro mammalian cell gene mutation test Genotoxicity in non – vivo mouse genotoxic micronucleus test 7.1. Acute toxicity oral – 7.1.1 Analogue chemical 1 Analogue chemical 1 Regulation for the Enforcement of the Federal Hazardous Substance Act (16 CFR 1500). Species/Strain Rat/Sprague-Dawley derived, albino rats Vehicle Undiluted Remarks - Method The protocol was followed without deviation. Group Number and Sex Dose Mortality of Animals mg/kg bw 1 5 per sex 5000 0
Rat, inhalation LC50 < 5.1 mg/L/1 hour harmful Rabbit, skin irritation (3 studies) slightly irritating Rabbit, skin irritation moderately irritating (based on 24 hour exposure) Rabbit, eye irritation (4 studies) slightly irritating Guinea pig, skin sensitisation – adjuvant test. limited evidence of Guinea pig, skin sensitisation – adjuvant test (2 studies) no evidence of Rat, repeat toxicity – 91 days. NOEL = 500 mg/kg bw/day Genotoxicity – bacterial reverse mutation non mutagenic Genotoxicity – in vitro chromosomal aberrations in human lymphocytes non genotoxic Genotoxicity – in vitro mammalian cell gene mutation test equivocal Genotoxicity – in vivo mouse micronucleus test non genotoxic 7.1. Acute toxicity – oral 7.1.1 Analogue chemical 1 Analogue chemical 1 Regulation for the Enforcement of the Federal Hazardous Substance Act (16 CFR 1500). Species/Strain Rat/Sprague-Dawley derived, albino rats Vehicle Undiluted Remarks - Method The protocol was followed without deviation. Group Number and Sex of Animals Dose mg/kg bw Mortality 1 5 per sex 5000 0
STD1301FR.docx