Parallel To test the 211 participants with Intervention Compliance by Baseline dietary Significant No clear Davidson 1991 effects of borderline or high groups consumed recording and fibre appeared decreases in total for increasing enrolled in diet 28g, 56g or 84g of return of unused systematically and LDL-C in and amounts of stabilisation phase. 156 oatmeal or oat packets. Dietary different, with groups consuming cholesterol. oatmeal and oat stable” subjects bran per day to intake by 4d food higher baseline 56g and 84g oat “diet bran consumed randomised. 148 give 1.2. 2.4, 3.6, records. levels in bran, and 84g calculation in combination completed study, 140 2.0, 4.0, 6.0g RMANOVA participants oatmeal. performed for with a NCEP included in per protocol Blood lipids by assigned to total cholesterol. Step 1 diet. analysis. 6 oat groups respectively. standard higher -glucan increase in with 20-23 subjects, Control consumed techniques, consumption. control group 15 28g farina (low calculated. subjects. fibre cereal). Per protocol 8wk run-in, 6wk analysis reported, intervention ITT gave similar followed by 6wk results. washout. Davy 2002 Parallel To compare the 39 overweight men Oat group Compliance by Groups poorly Non-significant Total and LDL-C effects of 2 large (age 50-75, BMI 25-35) consumed 60g returning uneaten matched for decrease in total increased in serves per day participated, 36 oatmeal and 76g cereal, dietary baseline cholesterol and wheat group. of oat or completed the study oat bran cereal intake by 4d food saturated fat increase in cereals but lipid data reported per day to give records. and fibre intake. Significant on blood lipids for 35 (17 oat, 18 5.5g -glucan. Lipids measured Large decrease in and lipoproteins. wheat). Wheat group by nuclear differences in consumed 60g magnetic reductions in whole wheat hot resonance. dietary cereal and 81g cholesterol frosted wheat intake between cereal per day. groups. 12wk trial.
Davidson 1991 Parallel To test the effects of increasing amounts of oatmeal and oat bran consumed in combination with a NCEP Step 1 diet. 211 participants with borderline or high enrolled in diet stabilisation phase. 156 “diet stable” subjects randomised. 148 completed study, 140 included in per protocol analysis. 6 oat groups with 20-23 subjects, control group 15 subjects. Intervention groups consumed 28g, 56g or 84g of oatmeal or oat bran per day to give 1.2. 2.4, 3.6, 2.0, 4.0, 6.0g respectively. Control consumed 28g farina (low fibre cereal). 8wk run-in, 6wk intervention followed by 6wk washout. Compliance by recording and return of unused packets. Dietary intake by 4d food records. RMANOVA Blood lipids by standard techniques, calculated. Per protocol analysis reported, ITT gave similar results. Baseline dietary fibre appeared systematically different, with higher baseline levels in participants assigned to higher -glucan consumption. Significant decreases in total and LDL-C in groups consuming 56g and 84g oat bran, and 84g oatmeal. increase in No clear for and cholesterol. calculation performed for total cholesterol. Davy 2002 Parallel To compare the effects of 2 large serves per day of oat or cereals on blood lipids and lipoproteins. 39 overweight men (age 50-75, BMI 25-35) participated, 36 completed the study but lipid data reported for 35 (17 oat, 18 wheat). Oat group consumed 60g oatmeal and 76g oat bran cereal per day to give 5.5g -glucan. Wheat group consumed 60g whole wheat hot cereal and 81g frosted wheat cereal per day. 12wk trial. Compliance by returning uneaten cereal, dietary intake by 4d food records. Lipids measured by nuclear magnetic resonance. Groups poorly matched for baseline saturated fat and fibre intake. Large differences in reductions in dietary cholesterol intake between groups. Non-significant decrease in total cholesterol and increase in Significant decrease in Total and LDL-C increased in wheat group.
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx