TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 6 6.1 Exposure assessment 6 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2 Human health effects assessment 6 Acute toxicity, Irritation and Sensitisation 7 7 Health hazard classification 6.3. health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 9 7.2.1 Predicted No-Effect Concentration 9 7.3. Environmental risk assessment 9 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 9 Hazard classification 9 Human health risk assessment 9 Environmental risk assessment 9 Recommendations 10 Regulatory Obligations 10 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 14 B.1. toxicity oral 14 – B.2. Acute toxicity dermal 14 – B.3. Irritation - skin 15 B.4. Irritation eye 15 – B.5. Skin sensitisation 16 B.6. Repeat dose toxicity 17 B.7. Genotoxicity bacteria 18 – B.8. Genotoxicity in vitro 18 – B.9. Genotoxicity in vivo 19 – Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. Ready biodegradability 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 23 Bibliography 24
TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 6 6.1 Exposure assessment 6 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2 Human health effects assessment 6 Acute toxicity, Irritation and Sensitisation 7 Health hazard classification 7 6.3. health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 9 7.2.1 Predicted No-Effect Concentration 9 7.3. Environmental risk assessment 9 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 9 Hazard classification 9 Human health risk assessment 9 Environmental risk assessment 9 Recommendations 10 Regulatory Obligations 10 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 14 B.1. toxicity – oral 14 B.2. Acute toxicity – dermal 14 B.3. Irritation - skin 15 B.4. Irritation – eye 15 B.5. Skin sensitisation 16 B.6. Repeat dose toxicity 17 B.7. Genotoxicity – bacteria 18 B.8. Genotoxicity – in vitro 18 B.9. Genotoxicity – in vivo 19 Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. Ready biodegradability 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 23 Bibliography 24
STD1346FR.docx