symptoms and signs of AHF since the Greater 60-day mortality previous evaluation, and Higher CV or renal (1) and/or (2) occurred concomitantly with readmission rates instituting/increasing the dose of IV therapy or mechanical support WHF signs/symptoms necessitating intensification Longer length of or re-institution of IV or mechanical HF treatment hospitalization from admission to day 5 Reduced number of days alive out of hospital up to day 60 Greater 180-day CV mortality DOSE34 Worsening or persistent HF requiring rescue Persistent or worsening HF therapy (loop diuretic, thiazide, IV vasoactive up to day 3 agents, ultrafiltration, or mechanical or respiratory support) from randomization to day 3 RELAX-AHF31 WHF signs/symptoms necessitating intensification Greater 180-day all-cause or re-institution of IV or mechanical HF treatment mortality from admission to day 5 ROSE-AHF35 Worsening or persistent HF requiring rescue Persistent or worsening HF therapy (IV vasoactive agents, ultrafiltration, or up to day 3 mechanical or respiratory support) ADHERE16 Need for escalation of therapy (inotropic Greater mortality at 30 days medications or IV vasodilator) >12 hours after and 1 year hospital presentation, transfer to the intensive care Greater all-cause
symptoms and signs of AHF since the previous evaluation, and (1) and/or (2) occurred concomitantly with instituting/increasing the dose of IV therapy or mechanical support Greater 60-day mortality Higher CV or renal readmission rates WHF signs/symptoms necessitating intensification or re-institution of IV or mechanical HF treatment from admission to day 5 Longer length of hospitalization Reduced number of days alive out of hospital up to day 60 Greater 180-day CV mortality DOSE34 Worsening or persistent HF requiring rescue therapy (loop diuretic, thiazide, IV vasoactive agents, ultrafiltration, or mechanical or respiratory support) from randomization to day 3 Persistent or worsening HF up to day 3 RELAX-AHF31 WHF signs/symptoms necessitating intensification or re-institution of IV or mechanical HF treatment from admission to day 5 Greater 180-day all-cause mortality ROSE-AHF35 Worsening or persistent HF requiring rescue therapy (IV vasoactive agents, ultrafiltration, or mechanical or respiratory support) Persistent or worsening HF up to day 3 ADHERE16 Need for escalation of therapy (inotropic medications or IV vasodilator) >12 hours after hospital presentation, transfer to the intensive care Greater mortality at 30 days and 1 year Greater all-cause
Submission%20draft_WHF%20Review_13May2016.docx