AND A positive result on one of the following tests: hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), or nucleic acid test for hepatitis B virus DNA (including qualitative, quantitative and genotype testing), OR HBsAg positive or nucleic acid test for hepatitis B virus DNA (including qualitative, quantitative and genotype testing), or HBeAg positive two times at least 6 months apart (Any combination of these tests performed 6 months apart is acceptable.) Probable: A case with a single HBsAg positive or HBV DNA positive (including qualitative, quantitative and genotype testing), or HBeAg positive lab result when no IgM anti-HBc results are available Acute HBV infection Clinical Presentation: An illness with a discrete onset of symptoms consistent with acute viral hepatitis (e.g., fever, headache, malaise, anorexia, nausea, vomiting, diarrhea, and abdominal pain) and either a) jaundice or b) elevated serum alanine aminotransferase levels > 100 IU/L Confirmed: Clinically compatible case* not known to have chronic hepatitis B and positive AND IgM antibody to hepatitis B core antigen (IgM anti– HBc) positive, if done * A documented negative hepatitis B surface antigen (HBsAg) laboratory test result within 6 months prior to a positive test (either HBsAg, Hepatitis B antigen (HBeAg), or hepatitis “e” B virus nucleic acid testing (HBV NAT) including genotype) result does NOT require an acute clinical presentation to meet the surveillance case definition. Suspect: Positive IgM antibody to hepatitis B core antigen (IgM anti-HBc) that does not meet the clinical definition Note that the year into which a case is categorized is based upon the case’s Date”, which “Event is assigned by the following case characteristics, in decreasing order of specificity, dependent on
AND A positive result on one of the following tests: hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), or nucleic acid test for hepatitis B virus DNA (including qualitative, quantitative and genotype testing), OR HBsAg positive or nucleic acid test for hepatitis B virus DNA (including qualitative, quantitative and genotype testing), or HBeAg positive two times at least 6 months apart (Any combination of these tests performed 6 months apart is acceptable.) Probable: A case with a single HBsAg positive or HBV DNA positive (including qualitative, quantitative and genotype testing), or HBeAg positive lab result when no IgM anti-HBc results are available Acute HBV infection Clinical Presentation: An illness with a discrete onset of symptoms consistent with acute viral hepatitis (e.g., fever, headache, malaise, anorexia, nausea, vomiting, diarrhea, and abdominal pain) and either a) jaundice or b) elevated serum alanine aminotransferase levels > 100 IU/L Confirmed: Clinically compatible case* not known to have chronic hepatitis B and positive AND IgM antibody to hepatitis B core antigen (IgM anti– HBc) positive, if done * A documented negative hepatitis B surface antigen (HBsAg) laboratory test result within 6 months prior to a positive test (either HBsAg, Hepatitis B “e” antigen (HBeAg), or hepatitis B virus nucleic acid testing (HBV NAT) including genotype) result does NOT require an acute clinical presentation to meet the surveillance case definition. Suspect: Positive IgM antibody to hepatitis B core antigen (IgM anti-HBc) that does not meet the clinical definition Note that the year into which a case is categorized is based upon the case’s “Event Date”, which is assigned by the following case characteristics, in decreasing order of specificity, dependent on
std-surveillance-2016.docx