Parallel To assess the 43 healthy participants 4g -glucan as a Compliance by Groups well Non-significant calculation Biorklund 2008 effects of with mild soluble oat fibre daily recording of matched at decrease in total for change in consuming hypercholesterolaemia concentrate soup intake. baseline. cholesterol, LDL performed. in a (44% male). consumed daily as Dietary intake by and HDL-C. ready to eat a soup. 3wk run 3d. Blood lipids by meal on blood in, 5wk test standard lipid and period. techniques, postprandial calculated. glucose and ANOVA analysis insulin Statistical analysis response. by t-test. To determine 20 free-living -glucan as Compliance by Controlled by Significant Baseline lipids Braaten 1994 – whether -glucan hypercholesterolaemic or returned packets. cross-over decrease in total calculated from is responsible participants (47% maltodextrin Dietary intake by design. cholesterol and pooled values of for the male). 19 completed placebo, was 3d food record in Some LDL-C pre-test, placebo study. consumed twice first 2wk of each differences in and placebo effect daily in a drink. intervention fat and wash-out phase. of oat bran. Subgroup period. cholesterol Data for placebo analyses Blood lipids intake between groups performed on measured by oat and placebo presented in vs. automated phase. graph only. “responders” method, LDL-C “non-responders”. 1-3wk run-in, 2x calculated. 4wk intervention ANOVA and t-test with 3-4wk analysis. washout. Bremer 1991 To compare 12 participants aged Participants Dietary intake, Controlled by Non-significant lipid-lowering 38-66 (42% male) with consumed bread including bread, cross-over decreases in total effects of oat hyperlipidaemia and with oat or wheat recorded daily. design and daily cholesterol and compared to stable consumption of bran, average oat Blood lipids measurement of LD-C. HDL-C wheat bran. a lipid-lowering diet bran intake measured by food intake. increased in both 45/day. standardised groups, but was 2wk run in with 2x techniques with relatively 4wk interventions LDL-C calculated. decreased in oat separated by a Paired t-test group. 2wk washout. analysis.
Biorklund 2008 Parallel To assess the effects of consuming in a ready to eat meal on blood lipid and postprandial glucose and insulin response. 43 healthy participants with mild hypercholesterolaemia (44% male). 4g -glucan as a soluble oat fibre concentrate consumed daily as a soup. 3wk run in, 5wk test period. Compliance by daily recording of soup intake. Dietary intake by 3d. Blood lipids by standard techniques, calculated. ANOVA analysis Statistical analysis by t-test. Groups well matched at baseline. Non-significant decrease in total cholesterol, and HDL-C. calculation for change in LDL performed. Braaten 1994 – To determine whether -glucan is responsible for the effect of oat bran. 20 free-living hypercholesterolaemic participants (47% male). 19 completed study. -glucan as or maltodextrin placebo, was consumed twice daily in a drink. Subgroup analyses performed on “responders” vs. “non-responders”. 1-3wk run-in, 2x 4wk intervention with 3-4wk washout. Compliance by returned packets. Dietary intake by 3d food record in first 2wk of each intervention period. Blood lipids measured by automated method, LDL-C calculated. ANOVA and t-test analysis. Controlled by cross-over design. Some differences in fat and cholesterol intake between oat and placebo phase. Significant decrease in total cholesterol and LDL-C Baseline lipids calculated from pooled values of pre-test, placebo and placebo wash-out phase. Data for placebo groups presented in graph only. Bremer 1991 To compare lipid-lowering effects of oat compared to wheat bran. 12 participants aged 38-66 (42% male) with hyperlipidaemia and stable consumption of a lipid-lowering diet Participants consumed bread with oat or wheat bran, average oat bran intake 45/day. 2wk run in with 2x 4wk interventions separated by a 2wk washout. Dietary intake, including bread, recorded daily. Blood lipids measured by standardised techniques with LDL-C calculated. Paired t-test analysis. Controlled by cross-over design and daily measurement of food intake. Non-significant decreases in total cholesterol and LD-C. HDL-C increased in both groups, but was relatively decreased in oat group.
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx