Outcome Difference in risk N if Health Economic Impact QALY Economic Total Economic Impact between control implemented at service cost on health service impact per impact on and treatment 65% per person or costs if person QALYS if day implemented implemented Primary (included Severe lung disease -40% -236 - -$5,460 -$1m -$1m elsewhere) Mechanical -24 -70,944 -$104 -$7m - - -$7m ventilation (hours) Secondary Surfactant use -25% -236 -$500 -$0.1m - - -$0.1m Patent ductus -42% -148 -$4,182 -$0.6m -$5,460 -$0.8m -$1m arteriosus Caesarean sections +16% +151 +$5,014 +$0.8m - - +$0.8m Change in intervention costs +$0.5m Totals -$7m -$2m -$9m Columns may not sum due to rounding. Negative values are savings in the calculations. Health service/outcome Health Service Explanation and costing assumptions Reference cost per person or or Outcome day Severe lung QALY: -$5,460 Cost is captured in mechanical ventilation and surfactant use (no difference in Mathers et al.1999. The burden of disease and injury in Australia. AIHW disease average length of stay or NICU admission rates). Confirmed through interview cat. no. PHE 17. Canberra: AIHW. with senior trial investigators. AIHW disability weight 0.03 equivalent to surgically treated congenital atrial or ventricular septal defect. Impairment is for one year.
Outcome Difference in risk between control and treatment N if implemented at 65% Health service cost per person or day Economic Impact on health service costs if implemented QALY impact per person Economic impact on QALYS if implemented Total Economic Impact Primary Severe lung disease -40% -236 (included elsewhere) - -$5,460 -$1m -$1m Mechanical ventilation (hours) -24 -70,944 -$104 -$7m - - -$7m Secondary Surfactant use -25% -236 -$500 -$0.1m - - -$0.1m Patent ductus arteriosus -42% -148 -$4,182 -$0.6m -$5,460 -$0.8m -$1m Caesarean sections +16% +151 +$5,014 +$0.8m - - +$0.8m Change in intervention costs Totals +$0.5m -$7m -$2m -$9m Columns may not sum due to rounding. Negative values are savings in the calculations. Health Service or Outcome Health service/outcome cost per person or day Explanation and costing assumptions Reference Severe lung disease QALY: -$5,460 Cost is captured in mechanical ventilation and surfactant use (no difference in average length of stay or NICU admission rates). Confirmed through interview with senior trial investigators. AIHW disability weight 0.03 equivalent to surgically treated congenital atrial or ventricular septal defect. Impairment is for one year. Mathers et al.1999. The burden of disease and injury in Australia. AIHW cat. no. PHE 17. Canberra: AIHW.
Supplementary-Appendix-B-Economic-evaluation-of-investigator-initiated-clinical-trials-conducted-by-networks.docx