Parallel To test the effect 111 56g instant oats Compliance by High attrition. Non-significant No side effects Van Horn 1991 of consuming hypocholesterolaemic isocalorically food records. Baseline decrease in reported from moderate adults (50% male, substituted into Dietary intake by characteristics cholesterol and oat intake. amounts of 80 completed regular diet 3d food record at of groups well LDL-C. instant oats on study. (recorded baseline, 4 and matched at . consumption 54g). 8wks. Blood lipids baseline. concentration as Subgroup measured Saturated fat well as to analyses by enzymatically, intake changes assess dietary baseline LDL-C calculated. significantly adaptations to cholesterol, Statistical analysis between groups, the daily gender and BMI. by t-test. with decreased inclusion of oats. 8wk trial period. intake in intervention but increased intake in control group. Vortser 1986 To compare the 18 healthy 15g oat fibre Habitual food Minimised by No change in Study reported acceptability and undergraduate tablets (15 x 1g intake recorded at cross-over blood glucose. each period of some volunteers. 6 men and tablets). Wheat baseline. Blood design and Oat and wheat cross-over as biochemical 12 women (mean age bran tablets as lipids measured provision of supplements separate effects of a new 20y). Normal control. 2 x 3wk enzymatically, tablets. lowered total experiment. oats fibre tablet cholesterol values. intervention, with LDL-C measured Compliance and cholesterol and When to a similar 4wk washout directly. Blood dietary intake LDL-C in the first combined, there amount of wheat period. glucose tested, as through intervention were no bran. well as ease of intervention not period; only oat significant intake of recorded. supplements effects of oats supplements. lowered them in on total RMANOVA, the second. cholesterol or ANCOVA and LDL-C. Oat analysis. supplements were easier to take than wheat, with fewer side effects.
Van Horn 1991 Parallel To test the effect of consuming moderate amounts of instant oats on concentration as well as to assess dietary adaptations to the daily inclusion of oats. 111 hypocholesterolaemic adults (50% male, 80 completed study. 56g instant oats isocalorically substituted into regular diet (recorded consumption 54g). Subgroup analyses by baseline cholesterol, gender and BMI. 8wk trial period. Compliance by food records. Dietary intake by 3d food record at baseline, 4 and 8wks. Blood lipids measured enzymatically, LDL-C calculated. Statistical analysis by t-test. High attrition. Baseline characteristics of groups well matched at baseline. Saturated fat intake changes significantly between groups, with decreased intake in intervention but increased intake in control group. Non-significant decrease in cholesterol and LDL-C. . No side effects reported from oat intake. Vortser 1986 To compare the acceptability and some biochemical effects of a new oats fibre tablet to a similar amount of wheat bran. 18 healthy undergraduate volunteers. 6 men and 12 women (mean age 20y). Normal cholesterol values. 15g oat fibre tablets (15 x 1g tablets). Wheat bran tablets as control. 2 x 3wk intervention, with 4wk washout period. Habitual food intake recorded at baseline. Blood lipids measured enzymatically, LDL-C measured directly. Blood glucose tested, as well as ease of intake of supplements. RMANOVA, ANCOVA and analysis. Minimised by cross-over design and provision of tablets. Compliance and dietary intake through intervention not recorded. No change in blood glucose. Oat and wheat supplements lowered total cholesterol and LDL-C in the first intervention period; only oat supplements lowered them in the second. Study reported each period of cross-over as separate experiment. When combined, there were no significant effects of oats on total cholesterol or LDL-C. Oat supplements were easier to take than wheat, with fewer side effects.
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx