Appendix 8 GRADE summary of findings table for barley* – Question: What is the food-health relationship between barley and blood cholesterol concentration? Effect Quality assessment of body of evidence Participants Quality estimate (degree of Number Risk Mean certainty in of Design of Inconsistency Indirectness Imprecision Considerations difference relationship) studies bias (95% CI) Change in total cholesterol -0.32 7 RCTs Low1 None None Serious# None 118 33 34 [-0.42, Moderate Change in total cholesterol baseline total cholesterol <5.5 mmol/L – -0.54 2 RCTs Low1 None None Serious# None 10 7 7 [-0.76, Moderate Change in total cholesterol baseline total cholesterol mmol/L – ≥5.5 -0.27 5 RCTs Low1 None None Serious# None 108 26 27 [-0.36, Moderate Change in LDL cholesterol -0.25 7 RCTs Low1 None None Serious# None 118 33 34 [-0.32, Moderate Change in LDL cholesterol baseline total cholesterol <5.5 mmol/L – -0.30 2 RCTs Low1 None None Serious# None 10 7 7 [-0.39, Moderate Change in LDL cholesterol baseline total cholesterol mmol/L – ≥5.5 -0.22 5 RCTs Low1 None None Serious# None 108 26 27 [-0.32, Moderate No change in HDL cholesterol -0.03 7 RCTs Low1 None None Serious None 118 33 34 [-0.06, Moderate 0.00]
Appendix 8 – GRADE summary of findings table for barley* Question: What is the food-health relationship between barley and blood cholesterol concentration? Quality assessment of body of evidence Participants Effect estimate Quality (degree of certainty in relationship) Number of studies Design Risk of bias Inconsistency Indirectness Imprecision Considerations Mean difference (95% CI) Change in total cholesterol 7 RCTs Low1 None None Serious# None 118 33 34 -0.32 [-0.42, Moderate Change in total cholesterol – baseline total cholesterol <5.5 mmol/L 2 RCTs Low1 None None Serious# None 10 7 7 -0.54 [-0.76, Moderate Change in total cholesterol – baseline total cholesterol ≥5.5 mmol/L 5 RCTs Low1 None None Serious# None 108 26 27 -0.27 [-0.36, Moderate Change in LDL cholesterol 7 RCTs Low1 None None Serious# None 118 33 34 -0.25 [-0.32, Moderate Change in LDL cholesterol – baseline total cholesterol <5.5 mmol/L 2 RCTs Low1 None None Serious# None 10 7 7 -0.30 [-0.39, Moderate Change in LDL cholesterol – baseline total cholesterol ≥5.5 mmol/L 5 RCTs Low1 None None Serious# None 108 26 27 -0.22 [-0.32, Moderate No change in HDL cholesterol 7 RCTs Low1 None None Serious None 118 33 34 -0.03 [-0.06, 0.00] Moderate
SR%20beta-glucan%20cholesterol%20-%20Master%20version.docx