Remarks The pH of a 5% solution of the chemical is 2-4. The notified chemical is stable below about pH 4.5. The chemical contains ester linkages that are expected to undergo hydrolysis quickly above pH 4.5 to 5 (Garcia 2000). et al., Partition Coefficient (n-octanol/water) Not determined Remarks The notified chemical is a quaternary ammonium surfactant. As such, it is not possible to measure the partition co-efficient and get meaningful results. Adsorption/Desorption Not determined Remarks The notified chemical is expected to undergo ion exchange in the environment and to adsorb strongly to clays and organic matter. Dissociation Constant Not determined Remarks The chemical is expected to dissociate completely in water at a concentration <20 mg/L. At concentrations >20 mg/L, the chemical is expected to aggregate, form a dispersive solution, and then precipitate. Particle Size Not determined Remarks Paste is not expected to form particles of respirable size. Flash Point 35 oC Pensky Martin closed cup method Remarks Test pressure not provided Not stated. Flammability Limits Not determined Remarks Expected to be combustible but not flammable Autoignition Temperature Not applicable Explosive Properties None Reactivity Stable and non- reactive at normal temperatures and conditions. 7. TOXICOLOGICAL INVESTIGATIONS Endpoint and Result Assessment Conclusion Rat, acute oral LD50 > 5000 mg/kg bw, low toxicity Rabbit, skin irritation Irritating Rabbit, skin irritation (20% notified chemical in water) Not irritating Rabbit, eye irritation Irritating Rabbit, eye irritation (20% notified chemical in water) Not irritating Guinea pig, skin sensitisation - adjuvant test Inadequate evidence of sensitisation. Guinea pig, skin sensitisation non-adjuvant test Non-sensitising – Skin Sensitisation Human Repeated Insult Patch Test Non-sensitising – Rat, Oral gavage repeat dose toxicity - 90 days. NOAEL 300 mg/kg – Genotoxicity - Bacterial Reverse Mutation Non mutagenic Genotoxicity in vivo Mammalian Erythrocyte Micronucleus Test Non genotoxic –
Remarks The pH of a 5% solution of the chemical is 2-4. The notified chemical is stable below about pH 4.5. The chemical contains ester linkages that are expected to undergo hydrolysis quickly above pH 4.5 to 5 (Garcia et al., 2000). Partition Coefficient (n-octanol/water) Not determined Remarks The notified chemical is a quaternary ammonium surfactant. As such, it is not possible to measure the partition co-efficient and get meaningful results. Adsorption/Desorption Not determined Remarks The notified chemical is expected to undergo ion exchange in the environment and to adsorb strongly to clays and organic matter. Dissociation Constant Not determined Remarks The chemical is expected to dissociate completely in water at a concentration <20 mg/L. At concentrations >20 mg/L, the chemical is expected to aggregate, form a dispersive solution, and then precipitate. Particle Size Not determined Remarks Paste is not expected to form particles of respirable size. Flash Point 35 oC Pensky Martin closed cup method Remarks Test pressure not provided Not stated. Flammability Limits Not determined Remarks Expected to be combustible but not flammable Autoignition Temperature Not applicable Explosive Properties None Reactivity Stable and non- reactive at normal temperatures and conditions. 7. TOXICOLOGICAL INVESTIGATIONS Endpoint and Result Assessment Conclusion Rat, acute oral LD50 > 5000 mg/kg bw, low toxicity Rabbit, skin irritation Irritating Rabbit, skin irritation (20% notified chemical in water) Not irritating Rabbit, eye irritation Irritating Rabbit, eye irritation (20% notified chemical in water) Not irritating Guinea pig, skin sensitisation - adjuvant test Inadequate evidence of sensitisation. Guinea pig, skin sensitisation – non-adjuvant test Non-sensitising Skin Sensitisation – Human Repeated Insult Patch Test Non-sensitising Rat, Oral – gavage repeat dose toxicity - 90 days. NOAEL 300 mg/kg Genotoxicity - Bacterial Reverse Mutation Non mutagenic Genotoxicity – in vivo Mammalian Erythrocyte Micronucleus Test Non genotoxic
STD-1027-FR.docx