OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1. Environmental Exposure 10 7.1.2. Environmental Fate 11 7.1.3. Predicted Environmental Concentration (PEC) 11 7.2. Environmental Effects Assessment 12 7.2.1. Predicted No-Effect Concentration 12 7.3. Environmental Risk Assessment 12 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity oral 15 – B.2. toxicity dermal 15 – B.3. Irritation skin 16 – B.4. Irritation eye 17 – B.5. Skin sensitisation mouse local lymph node assay (LLNA) 17 – B.6. Repeat dose toxicity 18 B.7. Genotoxicity bacteria 20 – B.8. Genotoxicity in vitro 21 – B.9. Genotoxicity in vitro 21 – B.10. Genotoxicity in vitro 23 – Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Ecotoxicological Investigations 25 C.1.1. Acute toxicity to fish 25 C.1.2. Acute toxicity to aquatic invertebrates 25 C.1.3. Algal growth inhibition test 26 C.1.4. Inhibition of microbial activity 27 BIBLIOGRAPHY 28
OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1. Environmental Exposure 10 7.1.2. Environmental Fate 11 7.1.3. Predicted Environmental Concentration (PEC) 11 7.2. Environmental Effects Assessment 12 7.2.1. Predicted No-Effect Concentration 12 7.3. Environmental Risk Assessment 12 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity – oral 15 B.2. toxicity – dermal 15 B.3. Irritation – skin 16 B.4. Irritation – eye 17 B.5. Skin sensitisation – mouse local lymph node assay (LLNA) 17 B.6. Repeat dose toxicity 18 B.7. Genotoxicity – bacteria 20 B.8. Genotoxicity – in vitro 21 B.9. Genotoxicity – in vitro 21 B.10. Genotoxicity – in vitro 23 Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Ecotoxicological Investigations 25 C.1.1. Acute toxicity to fish 25 C.1.2. Acute toxicity to aquatic invertebrates 25 C.1.3. Algal growth inhibition test 26 C.1.4. Inhibition of microbial activity 27 BIBLIOGRAPHY 28
STD1606FR.DOCX