OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure assessment 5 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1 Environmental Exposure 9 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 10 7.2. Environmental effects assessment 11 7.2.1 Predicted No-Effect Concentration 11 7.3. Environmental risk assessment 11 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 12 Hazard classification 12 Human health risk assessment 12 Environmental risk assessment 12 Recommendations 12 Regulatory Obligations 13 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 18 B.1. toxicity oral 18 – B.2. Acute toxicity dermal 18 – B.3. Irritation skin 19 – B.4. Irritation eye 19 – B.5. Skin sensitisation 20 B.6. Repeat dose toxicity 20 B.6. Genotoxicity bacteria 22 – B.7. Genotoxicity in vitro 22 – B.8. Genotoxicity in vivo 23 – Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.1.2. Inherent biodegradability 25 C.1.3. Potential for Bioaccumulation 26 C.2. Ecotoxicological Investigations 26 C.2.1. Acute toxicity to fish 26 C.2.2. Acute toxicity to aquatic invertebrates 27 C.2.3. Algal growth inhibition test 27 C.2.4. Inhibition of microbial activity 28 Bibliography 29
OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure assessment 5 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. health risk characterisation 8 6.3.1. Occupational health and safety 8 6.3.2. Public health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1 Environmental Exposure 9 7.1.2 Environmental fate 10 7.1.3 Predicted Environmental Concentration (PEC) 10 7.2. Environmental effects assessment 11 7.2.1 Predicted No-Effect Concentration 11 7.3. Environmental risk assessment 11 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 12 Hazard classification 12 Human health risk assessment 12 Environmental risk assessment 12 Recommendations 12 Regulatory Obligations 13 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 18 B.1. toxicity – oral 18 B.2. Acute toxicity – dermal 18 B.3. Irritation – skin 19 B.4. Irritation – eye 19 B.5. Skin sensitisation 20 B.6. Repeat dose toxicity 20 B.6. Genotoxicity – bacteria 22 B.7. Genotoxicity – in vitro 22 B.8. Genotoxicity – in vivo 23 Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.1.2. Inherent biodegradability 25 C.1.3. Potential for Bioaccumulation 26 C.2. Ecotoxicological Investigations 26 C.2.1. Acute toxicity to fish 26 C.2.2. Acute toxicity to aquatic invertebrates 27 C.2.3. Algal growth inhibition test 27 C.2.4. Inhibition of microbial activity 28 Bibliography 29
STD1272-FR.docx