Results 2. Table 1. Characterization of AmB formulations. Particle size is reported as volume distribution of the different populations and its corresponding percentage. Zeta potential values are reported as mean ± SD. Formulation Composition Appearance Size (nm - %) Zeta potential (mV) GCPQ GCPQ (5 mg mL-1) Transparent 16.7 nm 98.4% +16.0 ± 0.98 – >500 nm 1.6% – AmB in dextrose 5% AmB (1 mg mL-1) Opaque 1656 nm 72.3% -39.5 ± 3.1 – yellow 438.9 nm 27.7% – AmB-GCPQ before AmB (1 mg mL-1) Transparent 5610 nm 4.7% +3.0 ± 0.1 – centrifugation GCPQ (5 mg mL-1) yellow 170.5 nm - 28.3% 25.2 nm - 67% AmB-GCPQ after AmB (1 mg mL-1) Transparent 216 nm - 40.9% +3.0 ± 0.1 centrifugation GCPQ (5 mg mL-1) yellow 34.7 nm 59.6% – AMBd AmB (1 mg mL-1) Translucent 759.9 nm 96.2% -27.7 ± 5.8 – (AmB-desoxycholate) Sodium deoxycholate orange 182.5 nm 3.8% – (0.82 mg mL-1)
2. Results Table 1. Characterization of AmB formulations. Particle size is reported as volume distribution of the different populations and its corresponding percentage. Zeta potential values are reported as mean ± SD. Formulation Composition Appearance Size (nm - %) Zeta potential (mV) GCPQ GCPQ (5 mg mL-1) Transparent 16.7 nm – 98.4% >500 nm – 1.6% +16.0 ± 0.98 AmB in dextrose 5% AmB (1 mg mL-1) Opaque yellow 1656 nm – 72.3% 438.9 nm – 27.7% -39.5 ± 3.1 AmB-GCPQ before centrifugation AmB (1 mg mL-1) GCPQ (5 mg mL-1) Transparent yellow 5610 nm – 4.7% 170.5 nm - 28.3% 25.2 nm - 67% +3.0 ± 0.1 AmB-GCPQ after centrifugation AmB (1 mg mL-1) GCPQ (5 mg mL-1) Transparent yellow 216 nm - 40.9% 34.7 nm – 59.6% +3.0 ± 0.1 AMBd (AmB-desoxycholate) AmB (1 mg mL-1) Sodium deoxycholate (0.82 mg mL-1) Translucent orange 759.9 nm – 96.2% 182.5 nm – 3.8% -27.7 ± 5.8
Supporting_information_Serrano_et_al.docx