Nowson et Low risk (random Low risk Participants: 15.6% loss to No (high risk) No (low risk) High risk National Health al. (2003) number generator (Examiners low risk follow-up (and (data on and Medical used) blinded to unclear from changes in Research Providers: low allocation, study outcomes Committee and risk randomisation period) not reported the Rebecca – procedure unclear risk for Cooper Outcome stratified by hypertensive Foundation (low assessors: low household) pts.) risk) risk Summary table Citation Study Population Intervention Outcomes Sample size Compliance to Results & design level measured sodium target location of relevant to duration (urinary data) research question Parker et II Adult Participants pressure 59 (normal 4 weeks All participants: Mean difference (supine and al. males(aged 20 consumed a low alcohol: n= between low – Low sodium diet: standing) (1990), parallel 70 years), with sodium diet 28, low sodium period and 68.6 + 8.0 Australia design stable, treated (60mmol/day) plus alcohol: n= normal sodium mmol/24hr study hypertension 100mmol NaCl 31) period: [] (SBP: tablets/day for a 2 Normal sodium Supine: week run-in diet: 141.7 + 7.6 DBP<115mmHg) period. They were mmol/24hr Regular alcohol then randomly participants: Regular alcohol assigned to one of participants: four groups:
Nowson et al. (2003) Low risk (random number generator used) Low risk (Examiners blinded to allocation, randomisation procedure stratified by household) Participants: low risk Providers: low risk Outcome assessors: low risk 15.6% loss to follow-up (and unclear from study period) – unclear risk No (high risk) No (low risk) High risk (data on changes in outcomes not reported for hypertensive pts.) National Health and Medical Research Committee and the Rebecca Cooper Foundation (low risk) Summary table Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size duration Compliance to sodium target (urinary data) Results Parker et al. (1990), Australia [] parallel design study II Adult males(aged 20 – 70 years), with stable, treated hypertension (SBP: DBP<115mmHg) Participants consumed a low sodium diet (60mmol/day) plus 100mmol NaCl tablets/day for a 2 week run-in period. They were then randomly assigned to one of four groups: pressure (supine and standing) 59 (normal alcohol: n= 28, low alcohol: n= 31) 4 weeks All participants: Low sodium diet: 68.6 + 8.0 mmol/24hr Normal sodium diet: 141.7 + 7.6 mmol/24hr Regular alcohol participants: Mean difference between low sodium period and normal sodium period: Supine: Regular alcohol participants:
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