Intervention Reference Year No. Country Setting Age Samp. Relevant Outcome Point of Descriptor Parameter Value p Size Measure(s) Assessment [95% C.I.] -3.00 Euglycemia Biolo 2008 16 Italy Major 8 Phenylananine loss in 48 hours Difference in < 0.05a abdominal nmol/100ml/min means cancer +46.00 Glutamine uptake in Difference in < 0.05a resection nmol/100ml/min +0.78 Mikaeili 2012 17 Iran Medical ICU Adult 40 Incidence of CIP 18 days Relative risk 0.01d [0.10,0.95] reduction +20 Glutamine Tjader 2004 26 Sweden medical Adult 40 Muscle protein content 5 days Difference in NSg and surgical following 0.28g/kg in means ICU kg/kg Muscle protein content Difference in +305 < 0.05g following 0.57g/kg in means kg/kg +48 Muscle protein content Difference in < 0.05g following 0.86g/kg in means kg/kg -0.09 FSR of muscle following Difference in NSg 0.28g/kg in % means FSR of muscle following Difference in -0.16 NSg 0.57g/kg in % means FSR of muscle following Difference in -0.08 NSg 0.86g/kg in % 0.30 Growth Pichard 1996 18 Mechanical 20 Adductor pollicis force 12 days Difference in NSe Hormone ventilation measured in N means ≥ 7 days -4.70 Lean body mass in % Difference in NSe
Intervention Reference Year No. Country Setting Age Samp. Size Relevant Outcome Measure(s) Point of Assessment Descriptor Parameter Value [95% C.I.] p Euglycemia Biolo 2008 16 Italy Major abdominal cancer resection 8 Phenylananine loss in nmol/100ml/min 48 hours Difference in means -3.00 < 0.05a Glutamine uptake in nmol/100ml/min Difference in +46.00 < 0.05a Mikaeili 2012 17 Iran Medical ICU Adult 40 Incidence of CIP 18 days Relative risk reduction +0.78 [0.10,0.95] 0.01d Glutamine Tjader 2004 26 Sweden medical and surgical ICU Adult 40 Muscle protein content following 0.28g/kg in kg/kg 5 days Difference in means +20 NSg Muscle protein content following 0.57g/kg in kg/kg Difference in means +305 < 0.05g Muscle protein content following 0.86g/kg in kg/kg Difference in means +48 < 0.05g FSR of muscle following 0.28g/kg in % Difference in means -0.09 NSg FSR of muscle following 0.57g/kg in % Difference in means -0.16 NSg FSR of muscle following 0.86g/kg in % Difference in -0.08 NSg Growth Hormone Pichard 1996 18 Mechanical ventilation ≥ 7 days 20 Adductor pollicis force measured in N 12 days Difference in means 0.30 NSe Lean body mass in % Difference in -4.70 NSe
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