Study Population Age Medication Duration EMD Mean Funder () 33 children, 6-19 yrs Multivitamins 3 months MEMS 64% CF USA Foundation Traineeship () 36 children, 6-13 yrs Pancreatic 3 months MEMS* 43% Agency for USA Enzymes Healthcare & Research Quality () 28 children, 2-15 yrs Nebulised 1 year I-Neb 67% RLCH R&D UK Antibiotics fund () 24 children, 11-17 yrs Nebulised 1 year I 65% Not declared UK Antibiotics I-Neb Table 3 Mean adherence rates to therapy in children with CF when measured – electronically * MEMS- Medication Event Monitoring System Aardex, Union City, California, USA – Philips Respironics, UK 2.9 Trends in adherence for children with asthma and CF Data from these studies show that adherence rates are lower in older children and adolescents in asthma and CF (, , ), with the highest rates seen in children under the age of 6. In asthma, rates are lower in children from a poor socioeconomic background (, , , , ). The populations where adherence rates are highest are developed western countries such as the UK, the Netherlands, Australia & the USA, although these rates are often still below 75%. These studies with more adherent populations in developed countries also only included younger children (, , , , ). Adult studies have reported that adherence rates are higher in males than in females in both asthma() and CF (), but this has not been shown in paediatric populations. The studies which have reported this trend in adults have used prescription
Study Population Age Medication Duration EMD Mean Funder () 33 children, USA 6-19 yrs Multivitamins 3 months MEMS 64% CF Foundation Traineeship () 36 children, USA 6-13 yrs Pancreatic Enzymes 3 months MEMS* 43% Agency for Healthcare & Research Quality () 28 children, UK 2-15 yrs Nebulised Antibiotics 1 year I-Neb 67% RLCH R&D fund () 24 children, UK 11-17 yrs Nebulised Antibiotics 1 year I I-Neb 65% Not declared Table 3 – Mean adherence rates to therapy in children with CF when measured electronically * MEMS- Medication Event Monitoring System – Aardex, Union City, California, USA Philips Respironics, UK 2.9 Trends in adherence for children with asthma and CF Data from these studies show that adherence rates are lower in older children and adolescents in asthma and CF (, , ), with the highest rates seen in children under the age of 6. In asthma, rates are lower in children from a poor socioeconomic background (, , , , ). The populations where adherence rates are highest are developed western countries such as the UK, the Netherlands, Australia & the USA, although these rates are often still below 75%. These studies with more adherent populations in developed countries also only included younger children (, , , , ). Adult studies have reported that adherence rates are higher in males than in females in both asthma() and CF (), but this has not been shown in paediatric populations. The studies which have reported this trend in adults have used prescription
Rob_Morton_Thesis_Submission_December_2017.docx