Lactation: The safety of the veterinary medicinal product has not been established in lactating sows, thus its use is not recommended during lactation. Fertility: Do not use in breeding animals. 4.8 Interaction with other medicinal products and other forms of interaction The absorption of doxycycline can be reduced in the presence of high amounts of Ca2+, Fe3+, Mg2+ or Al3+ in the diet. Do not administer together with antacids, kaolin and iron preparations and in conjunction with bactericidal antibiotics like 4.9 Amounts to be administered and administration route To be administered orally, in medicated feeding stuff. The premix is administered directly mixed with feed according to the following dose: 10-12 mg of doxycycline/kg bodyweight/day, equivalent to 80-95 mg of the product/kg bodyweight/day. Treatment should be continued for 8 days. the intake of feed will vary depending on the clinical condition of the animals, in order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly. To calculate the dosage of the veterinary medicinal product, the following formula could be used as an example: 80 95 mg veterinary medicinal product/kg – mg of veterinary b.w./day x mean body weight (kg) of animals medicinal product per kg to be treated of feed = Mean daily feed intake/animal (kg) To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The recommended incorporation rate into feed would be 2 kg of the veterinary medicinal product per tonne of feed. The required doses should be measured by suitably calibrated weighing equipment. 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary Not described. 4.11 Withdrawal period(s) Pigs for fattening: Meat and offal: 5 days
Lactation: The safety of the veterinary medicinal product has not been established in lactating sows, thus its use is not recommended during lactation. Fertility: Do not use in breeding animals. 4.8 Interaction with other medicinal products and other forms of interaction The absorption of doxycycline can be reduced in the presence of high amounts of Ca2+, Fe3+, Mg2+ or Al3+ in the diet. Do not administer together with antacids, kaolin and iron preparations and in conjunction with bactericidal antibiotics like 4.9 Amounts to be administered and administration route To be administered orally, in medicated feeding stuff. The premix is administered directly mixed with feed according to the following dose: 10-12 mg of doxycycline/kg bodyweight/day, equivalent to 80-95 mg of the product/kg bodyweight/day. Treatment should be continued for 8 days. the intake of feed will vary depending on the clinical condition of the animals, in order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly. To calculate the dosage of the veterinary medicinal product, the following formula could be used as an example: mg of veterinary medicinal product per kg of feed = 80 – 95 mg veterinary medicinal product/kg b.w./day x mean body weight (kg) of animals to be treated Mean daily feed intake/animal (kg) To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The recommended incorporation rate into feed would be 2 kg of the veterinary medicinal product per tonne of feed. The required doses should be measured by suitably calibrated weighing equipment. 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary Not described. 4.11 Withdrawal period(s) Pigs for fattening: Meat and offal: 5 days
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