Unclear risk Unclear risk Participants: >45% (many No (high risk) No (low Yes (low risk) Not stated et al. (randomisation (method of unclear risk excluded due risk) (unclear risk) (1993), method not concealment of to compliance Providers: high Spain stated) allocation not cut-offs) – risk described, high risk stratified by Outcome locality and age) assessors: low risk Summary table Citation Study Population Intervention Outcomes Sample size Compliance to Results & design level measured duration sodium target location of relevant to (urinary data) research question Richards II Adults (aged Participants were pressure 12 4 - 6 weeks Low sodium diet: Mean difference (supine after et al. 19-52 randomised to start 100mmol/24hr between low 20 min rest, (1984), with mild one of three sodium period and standing after Normal sodium New essential arms: normal sodium 5 min), 24 hr. diet: Zealand study hypertension period: ambulatory control diet 200mmol/24hr (140/90 – pressure (180mmol [] SBP: -4mmHg (SEM: (during (p<0.001) sodium/day and 2.79, CI: -9.47, 1.47) out period) 60mmol Note: estimated potassium/day) from figure
et al. (1993), Spain Unclear risk (randomisation method not stated) Unclear risk (method of concealment of allocation not described, stratified by locality and age) Participants: unclear risk Providers: high risk Outcome assessors: low risk >45% (many excluded due to compliance cut-offs) – high risk No (high risk) No (low risk) Yes (low risk) Not stated (unclear risk) Summary table Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size duration Compliance to sodium target (urinary data) Results Richards et al. (1984), New Zealand [] study II Adults (aged 19-52 with mild essential hypertension (140/90 – Participants were randomised to start one of three arms: control diet (180mmol sodium/day and 60mmol potassium/day) pressure (supine after 20 min rest, standing after 5 min), 24 hr. ambulatory pressure (during period) 12 4 - 6 weeks Low sodium diet: 100mmol/24hr Normal sodium diet: 200mmol/24hr (p<0.001) Note: estimated from figure Mean difference between low sodium period and normal sodium period: SBP: -4mmHg (SEM: 2.79, CI: -9.47, 1.47) out
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