Fotherby Unclear risk (no Unclear risk (not Participants: low One No (unclear No (low risk) Yes (low British Heart et al. description of described) risk participant risk) risk) Foundation (low (1993) method of (5.6%) lost to risk) Providers: low and sequence follow-up (low risk Fotherby generation) risk) et al. Outcome (1997) assessors: unclear risk Summary table Citation Study Population Intervention Outcomes Sample Intervention Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question Gates et II Adults (aged Participants Blood pressure 12 4 weeks Normal sodium Mean difference (seated and al. 50 years) randomly allocated period: ~ 160 between low sodium – supine), 24hr (2004), with stage 1 to start on one of 170mmol/24hr diet to normal sodium ambulatory USA over systolic two cross-over (estimated from diet: BP, total study hypertension arms: figure, exact cholesterol, [] Supine: values not given) HDL, LDL 1. Reduced sodium SBP: -3mmHg (SEM: diet plus salt Low sodium 1.84, CI: -6.61, -0.61) tablets (intended period: ~60 – to return 70mmol/24hr DBP: -1.2mmHg (SEM: participants to trial (estimated from 1.46, CI: -4.06, 1.66)
Fotherby et al. (1993) and Fotherby et al. (1997) Unclear risk (no description of method of sequence generation) Unclear risk (not described) Participants: low risk Providers: low risk Outcome assessors: unclear risk One participant (5.6%) lost to follow-up (low risk) No (unclear risk) No (low risk) Yes (low risk) British Heart Foundation (low risk) Summary table Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results Gates et al. (2004), USA [] study II Adults (aged 50 years) with stage 1 systolic hypertension Participants randomly allocated to start on one of two cross-over arms: 1. Reduced sodium diet plus salt tablets (intended to return participants to Blood pressure (seated and supine), 24hr ambulatory BP, total cholesterol, HDL, LDL 12 4 weeks Normal sodium period: ~ 160 – 170mmol/24hr (estimated from figure, exact values not given) Low sodium period: ~60 – 70mmol/24hr (estimated from Mean difference between low sodium diet to normal sodium diet: Supine: SBP: -3mmHg (SEM: 1.84, CI: -6.61, -0.61) DBP: -1.2mmHg (SEM: 1.46, CI: -4.06, 1.66) over trial
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