(DBP: 95 2. Dietary advice however Control group 180 SBP: -1.5mmHg (SEM: – insufficient 109mmHg) to reduce sodium (SEM: 9) 5.55, CI: -12.38, -9.38) data reported intake to 70 mmol/24hr – in paper to DBP: -7mmHg (SEM: 100mmol/day analyse (p<0.05) 2.77, CI: -12.43, -1.57) 3. chlorothiazide Mortality: (500 mg twice daily) 1 participant in the restricted sodium 4. propranolol (up died due to MI to 480 mg/day) (compared to 0 and a diuretic participants in control, Note: only groups statistical analysis not 1 and 2 used in conducted) this analysis Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing Reporting all Funding source randomisation concealment study early outcome results where for benefit required
(DBP: 95 – 109mmHg) 2. Dietary advice to reduce sodium intake to 70 – 100mmol/day 3. chlorothiazide (500 mg twice daily) 4. propranolol (up to 480 mg/day) and a diuretic Note: only groups 1 and 2 used in this analysis however insufficient data reported in paper to analyse Control group 180 (SEM: 9) mmol/24hr (p<0.05) SBP: -1.5mmHg (SEM: 5.55, CI: -12.38, -9.38) DBP: -7mmHg (SEM: 2.77, CI: -12.43, -1.57) Mortality: 1 participant in the restricted sodium died due to MI (compared to 0 participants in control, statistical analysis not conducted) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to Use of where required Ceasing study early for benefit Reporting all outcome results Funding source
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx