II Older adults All participants pressure 47 (18 4 weeks Normotensive pts.: Mean changes between (supine), total et al. (60 78 were prescribed a NT, 29 Normal sodium low sodium diet to – cholesterol (1997), years), both reduced sodium HT) period: 167 + 54 normal sodium diet: UK over diet (80mmol/day) mmol/24hr Normotensive pts. study and for 2 weeks. [] Low sodium period: hypertensive Following this SBP: -8.1mmHg (SEM: 91 + 54 mmol/24hr (SBP range: period, they were 2.77, CI: -13.53, -2.67) (p<0.001) 123 then allocated to a – DBP: -3.9mmHg (SEM: 205mmHg, cross-over arm: Hypertensive pts.: 1.54, CI: -6.92, -0.88) DBP range: Normal sodium 1. 12 sodium 64 – period: 182 + 46 Hypertensive pts. tablets/day (total 112mmHg) mmol/24hr of 120mmol/day) SBP: -6.6 mmHg Low sodium period: (SEM:2.51, CI: -11.52, 2. 12 placebo 95 + 48 mmol/24hr tablets/day (p<0.001) DBP: -2.8mmHg (SEM: 1.33, CI: -5.41, -0.19) Mean total cholesterol was 5.9+ 1.1 mg/dL during normal sodium period and 6.0 + 1.0 mg/dL during low salt period (NS, p-value not given, not given separately for HT and NT pts.)
et al. (1997), UK [] study II Older adults (60 – 78 years), both and hypertensive (SBP range: 123 – 205mmHg, DBP range: 64 – 112mmHg) All participants were prescribed a reduced sodium diet (80mmol/day) for 2 weeks. Following this period, they were then allocated to a cross-over arm: 1. 12 sodium tablets/day (total of 120mmol/day) 2. 12 placebo tablets/day pressure (supine), total cholesterol 47 (18 NT, 29 HT) 4 weeks Normotensive pts.: Normal sodium period: 167 + 54 mmol/24hr Low sodium period: 91 + 54 mmol/24hr (p<0.001) Hypertensive pts.: Normal sodium period: 182 + 46 mmol/24hr Low sodium period: 95 + 48 mmol/24hr (p<0.001) Mean changes between low sodium diet to normal sodium diet: Normotensive pts. SBP: -8.1mmHg (SEM: 2.77, CI: -13.53, -2.67) DBP: -3.9mmHg (SEM: 1.54, CI: -6.92, -0.88) Hypertensive pts. SBP: -6.6 mmHg (SEM:2.51, CI: -11.52, DBP: -2.8mmHg (SEM: 1.33, CI: -5.41, -0.19) Mean total cholesterol was 5.9+ 1.1 mg/dL during normal sodium period and 6.0 + 1.0 mg/dL during low salt period (NS, p-value not given, not given separately for HT and NT pts.) over
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