Citation Study Population Intervention Outcomes Sample Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question Ruppert II Adults (aged All participants were Blood pressure 25 4 weeks Low sodium diet: Mean difference (supine after instructed to et al. 27 75 82 + between low sodium – 30 min rest), consume a diet (1993), years) 3.4mmol/24hr period and normal mean arterial containing 85mmol Germany sodium period: pressure, total Normal sodium sodium/day. study cholesterol, [] diet: 199.6 + 5.3 SBP: 1.70mmHg (CI: Participants were LDL, HDL then randomised to mmol/24hr 8.38) who had start one of two previously (p<0.001) DBP: (CI: -3.47, cross-over arms: participated 5.47) 1. Restricted sodium in one week diet plus NaCl Cholesterol: 0.00mmol/L study of NaCl capsules (total daily (CI: -0.46, 0.46) and placebo sodium intake: (cannot be HDL:-0.04mmol/L (CI: 200mmol/day) included in 0.15) current 2. Restricted sodium analysis due diet plus placebo LDL: 0.13mmol/L (CI: to duration) daily sodium intake: 0.54) 85mmol/day) (All values from WHO) Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing Reporting all Funding source randomisation concealment study outcome results
Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size duration Compliance to sodium target (urinary data) Results Ruppert et al. (1993), Germany [] study II Adults (aged 27 – 75 years) who had previously participated in one week study of NaCl and placebo (cannot be included in current analysis due to duration) All participants were instructed to consume a diet containing 85mmol sodium/day. Participants were then randomised to start one of two cross-over arms: 1. Restricted sodium diet plus NaCl capsules (total daily sodium intake: 200mmol/day) 2. Restricted sodium diet plus placebo daily sodium intake: 85mmol/day) Blood pressure (supine after 30 min rest), mean arterial pressure, total cholesterol, LDL, HDL 25 4 weeks Low sodium diet: 82 + 3.4mmol/24hr Normal sodium diet: 199.6 + 5.3 mmol/24hr (p<0.001) Mean difference between low sodium period and normal sodium period: SBP: 1.70mmHg (CI: 8.38) DBP: (CI: -3.47, 5.47) Cholesterol: 0.00mmol/L (CI: -0.46, 0.46) HDL:-0.04mmol/L (CI: 0.15) LDL: 0.13mmol/L (CI: 0.54) (All values from WHO) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to Use of Ceasing study Reporting all outcome results Funding source
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx