Summary table Citation Study Population Intervention Outcomes Sample Intervention Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question II Adults (aged Following dietary pressure 19 4 weeks Normal sodium Mean (supine and et al. with mild to instructions to diet: 160 mmHg difference standing), (1982), moderate consume a reduced (estimated from between low mean arterial UK hypertension salt diet (with a goal of figure, exact values sodium diet to pressure study (SBP: 135 60 - 80mmol/day) for not given) normal sodium – [] 185mmHg, DBP: 2 weeks, participants diet: Insufficient Low sodium diet: 90 110mmHg) were randomly data in to – 83 + 11 mmHg Seated: calculate MAP allocated to start one of the two cross-over (p<0.001) SBP: -10mmHg arms: (SEM: 2.76, CI: -15.41, -4.59) 1. Reduced salt diet with sodium “slow” DBP: -5mmHg supplementation (SEM: 1.76, CI: (designed to restore -8.45, -1.55) sodium intake to match pt.’s baseline urinary sodium excretion) 2. Reduced salt diet with placebo Key features for bias assessment of randomised trials
Summary table Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results et al. (1982), UK [] study II Adults (aged with mild to moderate hypertension (SBP: 135 – 185mmHg, DBP: 90 – 110mmHg) Following dietary instructions to consume a reduced salt diet (with a goal of 60 - 80mmol/day) for 2 weeks, participants were randomly allocated to start one of the two cross-over arms: 1. Reduced salt diet with “slow” sodium supplementation (designed to restore sodium intake to match pt.’s baseline urinary sodium excretion) 2. Reduced salt diet with placebo pressure (supine and standing), mean arterial pressure Insufficient data in to calculate MAP 19 4 weeks Normal sodium diet: 160 mmHg (estimated from figure, exact values not given) Low sodium diet: 83 + 11 mmHg (p<0.001) Mean difference between low sodium diet to normal sodium diet: Seated: SBP: -10mmHg (SEM: 2.76, CI: -15.41, -4.59) DBP: -5mmHg (SEM: 1.76, CI: -8.45, -1.55) Key features for bias assessment of randomised trials
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