Citation Study Population Intervention Outcomes Sample size Compliance to Results & design level measured sodium target location of relevant to (urinary data) research question Swift II African or Following a run in Blood 46 4 weeks urinary sodium Mean changes between pressure (2005), African period on usual randomised, excretion in study low sodium and higher (measured UK double diet, then advice to 40 groups: sodium groups (based on blind, descent reduce salt intake completed supine BP): by a [] Higher sodium placebo (mean age to 5g/day, nurse), 24 SBP: (SEM: 2.06, 50±10 Participants were hour 169±73mmol/24 95%CI: -12.04, -3.96) cross years), randomised to one ambulatory hours BP of two groups: DBP: -3mmHg (SEM: Placebo (lower not taking 1.11, 95%CI: -5.18, -0.82) 1.Reduced sodium sodium) group: medication (low salt diet + *no baseline 24 hour 89±52mmol/24 placebo tablets) ambulatory BP available DBP hours to calculate change ≥90mmHg) 2. Higher sodium Mean fall in urinary (low salt diet + Mean SBP sodium excretion 120mmol/day slow 156±12, was 78±62mmol.24 sodium tablets) in a mean DBP (P<0.001) cross over design
Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Compliance to sodium target (urinary data) Results Swift (2005), UK [] double blind, placebo cross II African or African descent (mean age 50±10 years), not taking medication DBP ≥90mmHg) Mean SBP 156±12, mean DBP Following a run in period on usual diet, then advice to reduce salt intake to 5g/day, Participants were randomised to one of two groups: 1.Reduced sodium (low salt diet + placebo tablets) 2. Higher sodium (low salt diet + 120mmol/day slow sodium tablets) in a cross over design Blood pressure (measured by a nurse), 24 hour ambulatory BP 46 randomised, 40 completed 4 weeks urinary sodium excretion in study groups: Higher sodium 169±73mmol/24 hours Placebo (lower sodium) group: 89±52mmol/24 hours Mean fall in urinary sodium excretion was 78±62mmol.24 (P<0.001) Mean changes between low sodium and higher sodium groups (based on supine BP): SBP: (SEM: 2.06, 95%CI: -12.04, -3.96) DBP: -3mmHg (SEM: 1.11, 95%CI: -5.18, -0.82) *no baseline 24 hour ambulatory BP available to calculate change
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