Citation Population Intervention Outcomes Sample size Intervention Compliance to Results & design level measured duration sodium target location of relevant to (urinary data) research question Melander II Adults (mean All participants pressure 39 4 weeks Low sodium period: Mean (supine after et al. age 53±11 received all meals 50.7 + 17.3 difference 30 min rest), (2007), years), without and drinks mmol/24hr between low 24hr Sweden known throughout the sodium period ambulatory BP Normal sodium study hypertension study duration to and normal [] period: 140 + 39.5 (mean SBP: provide a total sodium period: mmol/24hr 139mmHg, daily intake of Supine: mean DBP: 50mmol of (p<0.0001) 86.3mmHg) sodium/salt (NaCl). SBP: -6mmHg Participants were (SEM: 1.18, CI: randomly -8.31, -3.69) allocated to start DBP: -2.3mmHg one of the two (SEM: 0.86, CI: cross-over arms: -3.99, -0.61) 1. Provided food and drinks plus 100mmol NaCl/day 2. Provided food and drinks plus placebo Key features for bias assessment of randomised trials
Citation & location design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results Melander et al. (2007), Sweden [] study II Adults (mean age 53±11 years), without known hypertension (mean SBP: 139mmHg, mean DBP: 86.3mmHg) All participants received all meals and drinks throughout the study duration to provide a total daily intake of 50mmol of sodium/salt (NaCl). Participants were randomly allocated to start one of the two cross-over arms: 1. Provided food and drinks plus 100mmol NaCl/day 2. Provided food and drinks plus placebo pressure (supine after 30 min rest), 24hr ambulatory BP 39 4 weeks Low sodium period: 50.7 + 17.3 mmol/24hr Normal sodium period: 140 + 39.5 mmol/24hr (p<0.0001) Mean difference between low sodium period and normal sodium period: Supine: SBP: -6mmHg (SEM: 1.18, CI: -8.31, -3.69) DBP: -2.3mmHg (SEM: 0.86, CI: -3.99, -0.61) Key features for bias assessment of randomised trials
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