research question Weir et II Adults with Participants were Resting BP, 132 4 weeks Mean 24 hour Difference in resting SBP 24 hour al. hypertension randomised to per urinary between groups: -9.4mmHg ambulatory (2010), (range SBP intervention groups sodium (0.97SEM, 95%CI: -11.3, -7.50) BP USA in a cross excretion: Difference in resting DBP blinded design (no washout [] Low sodium between groups: end aged 16-60 period) diet: point years, taking -5.7mmHg (0.66SEM, 95%CI: Low sodium 300mg/day 84.8mEq -4.41) diet aliskiren sodium/ 24 (≤100mmol maDBP was lower with the cross (direct renin hours sodium/day), lower sodium diet compared to over inhibitor for dietitian advice High sodium the higher sodium diet (LSM study treatment of provided diet: difference: 5.7mmHg, 95%CI, HT) High sodium 4.4-6.9, p<.0001) (raw data 207.6mEq diet entered into excel sheet) sodium/24 (≥200mmol hours maSBP was lower with the low sodium/day), sodium diet compared with the dietitian advice (P<0.0001) high sodium diet (LSM provided difference: 9.4mmHg, 95%ci: 7.5-11.4) (raw data entered into excel sheet) Key features for bias assessment of randomised trials
research question Weir et al. (2010), USA [] blinded end point cross over study II Adults with hypertension (range SBP aged 16-60 years, taking 300mg/day aliskiren (direct renin inhibitor for treatment of HT) Participants were randomised to intervention groups in a cross design (no washout period) Low sodium diet (≤100mmol sodium/day), dietitian advice provided High sodium diet (≥200mmol sodium/day), dietitian advice provided Resting BP, 24 hour ambulatory BP 132 4 weeks per Mean 24 hour urinary sodium excretion: Low sodium diet: 84.8mEq sodium/ 24 hours High sodium diet: 207.6mEq sodium/24 hours (P<0.0001) Difference in resting SBP between groups: -9.4mmHg (0.97SEM, 95%CI: -11.3, -7.50) Difference in resting DBP between groups: -5.7mmHg (0.66SEM, 95%CI: -4.41) maDBP was lower with the lower sodium diet compared to the higher sodium diet (LSM difference: 5.7mmHg, 95%CI, 4.4-6.9, p<.0001) (raw data entered into excel sheet) maSBP was lower with the low sodium diet compared with the high sodium diet (LSM difference: 9.4mmHg, 95%ci: 7.5-11.4) (raw data entered into excel sheet) Key features for bias assessment of randomised trials
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx