had pTis disease, 13.5% (n=7) had pT1 disease and 34.6% (n=18) patients had pT2-4 disease. With regards to the 20 normal urothelial samples, the male to female ratio was 9:1 (18 versus 2) with the same age range as the bladder cancer samples of 90. The 10 samples that were from patients who had no history of bladder cancer were obtained from patients who underwent trans-urethral resection of prostate (n=4) and radical prostatectomy (n=6). The 10 macroscopically normal looking samples that were collected from patients with bladder cancer were obtained from patients that either underwent a radical cystectomy (n=7) or a trans-urethral resection of bladder tumour (n=3). Overall follow-up of bladder cancer patients incorporating all grades of disease ranged from 2-93 months. This represented a mean follow up of 43.4, 57 and 23.5 months for NMI, high-grade NMI and invasive disease respectively. Bladder cancer Normal urothelium Low-grade High-grade Invasive Cancer NMI NMI history Total 22 12 18 10 10 Gender Male 14 12 14 10 8 Female 8 0 4 0 2 Age Mean 75 71.9 71.4 67 66.4 Range 56-83 55-81 46-90 54-81 46-90 Source TURP 4 RP 6 TURBT 3 RC 7 Grade
had pTis disease, 13.5% (n=7) had pT1 disease and 34.6% (n=18) patients had pT2-4 disease. With regards to the 20 normal urothelial samples, the male to female ratio was 9:1 (18 versus 2) with the same age range as the bladder cancer samples of The 10 samples that were from patients who had no history of bladder cancer were obtained from patients who underwent trans-urethral resection of prostate (n=4) and radical prostatectomy (n=6). The 10 macroscopically normal looking samples that were collected from patients with bladder cancer were obtained from patients that either underwent a radical cystectomy (n=7) or a trans-urethral resection of bladder tumour (n=3). Overall follow-up of bladder cancer patients incorporating all grades of disease ranged from 2-93 months. This represented a mean follow up of 43.4, 57 and 23.5 months for NMI, high-grade NMI and invasive disease respectively. Bladder cancer Normal urothelium Low-grade NMI High-grade NMI Invasive Cancer history Total 22 12 18 10 10 Gender Male Female 14 8 12 0 14 4 10 0 8 2 Age Mean Range 75 56-83 71.9 55-81 71.4 46-90 67 54-81 66.4 46-90 Source TURP RP TURBT RC 4 6 3 7 Grade 90.
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