Where: the margin of exposure during human health MoE = Margin of Exposure risk characterisation. PoD = of Departure (e.g. NOAEL) in mg/kg/d Intake = Intake in mg/kg/day from all exposure routes 6 Formula used to derive the risk quotient during Where: human health risk RQ = Risk Quotient characterisation. Intake = Intake in mg/kg/day T-TRV = Threshold Toxicity Reference Value (TRV) in mg/kg/day 7 Formula used to derive the risk index during human health risk Overall RI = for each exposure pathway characterisation. ∑RQ RQ = Risk Quotient 8 Formula used to derive the increased lifetime Where: cancer risk during ILCR = Increased lifetime cancer risks human health risk Intake = Intake in mg/kg/day characterisation. Exposure concentration = Exposure concentration in mg/m3 TRV Reference Value mg/kg/day 9 General formula for calculating a Predicted No Effect PNEC = Predicted No Effect Concentration Concentration. Assessment factor = safety or uncertainty factor - General formula for calculating the Maximum Acceptable MATC = Maximum Acceptable Toxicant Concentration Toxicant Concentration (MATC) NOEC = No Observable Effects Concentration Included here, for LOEC = Lowest Observable Effects Concentration information only. Its use is not recommended (previously used in effects assessment – reported as the geometric mean between NOEC and LOEC)
Where: MoE = Margin of Exposure PoD = of Departure (e.g. NOAEL) in mg/kg/d Intake = Intake in mg/kg/day from all exposure routes the margin of exposure during human health risk characterisation. 6 Where: RQ = Risk Quotient Intake = Intake in mg/kg/day T-TRV = Threshold Toxicity Reference Value (TRV) in mg/kg/day Formula used to derive the risk quotient during human health risk characterisation. 7 Overall RI = ∑RQ for each exposure pathway RQ = Risk Quotient Formula used to derive the risk index during human health risk characterisation. 8 Where: ILCR = Increased lifetime cancer risks Intake = Intake in mg/kg/day Exposure concentration = Exposure concentration in mg/m3 TRV Reference Value mg/kg/day Formula used to derive the increased lifetime cancer risk during human health risk characterisation. 9 PNEC = Predicted No Effect Concentration Assessment factor = safety or uncertainty factor General formula for calculating a Predicted No Effect Concentration. - MATC = Maximum Acceptable Toxicant Concentration NOEC = No Observable Effects Concentration LOEC = Lowest Observable Effects Concentration General formula for calculating the Maximum Acceptable Toxicant Concentration (MATC) Included here, for information only. Its use is not recommended (previously used in effects assessment – reported as the geometric mean between NOEC and LOEC)
risk-assessment-guidance-manual-chemicals-associated-csg-extraction-australia-exposure-draft.docx