Appendix 7: GRADE evidence profile Quality assessment No of patients Effect Quality Other No of A low intake of A high intake of Design Risk of bias Inconsistency Indirectness Imprecision Absolute studies sodium sodium systolic blood pressure (all participants) (follow-up 4 - 156 weeks; measured with: resting; Better indicated by lower values) 61 no serious risk of serious2 no serious no serious none5 3592 3634 MD 3.9 lower (4.7 to 3 lower)  trials bias1 indirectness3 imprecision4 systolic blood pressure (HT participants only) (follow-up 4 - 104 weeks; measured with: resting; Better indicated by lower values) 42 no serious risk of no serious no serious no serious none9 1672 1609 MD 4.7 (5.8 to 3.6 lower)  trials bias inconsistency7 indirectness imprecision8 HIGH systolic blood pressure (NT participants only) (follow-up 6 - 156 weeks; measured with: resting; Better indicated by lower values) 13 no serious risk of no serious no serious no serious none12 1394 1495 MD 1.0 (1.8 to 0.2 lower)  trials bias inconsistency10 indirectness imprecision11 HIGH systolic pressure (mixed hypertension status) (follow-up 4 - 6 weeks; measured with: resting; Better indicated by lower values) 6 no serious risk of serious13 no serious no serious none15 526 530 MD 4.4 lower (6.7 to 2.1 lower)  trials bias indirectness imprecision14 Total cholesterol (follow-up 4 - 8 weeks; Better indicated by lower values) 16 no serious risk of no serious no serious no serious none18 804 803 MD 0.03 higher (0.02 lower to  trials bias inconsistency16 indirectness imprecision17 0.08 higher) HIGH
Appendix 7: GRADE evidence profile Quality assessment No of patients Effect Quality No of studies Design Risk of bias Inconsistency Indirectness Imprecision Other A low intake of sodium A high intake of sodium Absolute systolic blood pressure (all participants) (follow-up 4 - 156 weeks; measured with: resting; Better indicated by lower values) 61 trials no serious risk of bias1 serious2 no serious indirectness3 no serious imprecision4 none5 3592 3634 MD 3.9 lower (4.7 to 3 lower)  systolic blood pressure (HT participants only) (follow-up 4 - 104 weeks; measured with: resting; Better indicated by lower values) 42 trials no serious risk of bias no serious inconsistency7 no serious indirectness no serious imprecision8 none9 1672 1609 MD 4.7 (5.8 to 3.6 lower)  HIGH systolic blood pressure (NT participants only) (follow-up 6 - 156 weeks; measured with: resting; Better indicated by lower values) 13 trials no serious risk of bias no serious inconsistency10 no serious indirectness no serious imprecision11 none12 1394 1495 MD 1.0 (1.8 to 0.2 lower)  HIGH systolic pressure (mixed hypertension status) (follow-up 4 - 6 weeks; measured with: resting; Better indicated by lower values) 6 trials no serious risk of bias serious13 no serious indirectness no serious imprecision14 none15 526 530 MD 4.4 lower (6.7 to 2.1 lower)  Total cholesterol (follow-up 4 - 8 weeks; Better indicated by lower values) 16 trials no serious risk of bias no serious inconsistency16 no serious indirectness no serious imprecision17 none18 804 803 MD 0.03 higher (0.02 lower to 0.08 higher)  HIGH
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx