Citation Study Population Intervention Outcomes Sample Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question Grobbee II adults (18 Participants Blood pressure 40 6 weeks Normal sodium Mean difference (supine), et al. 28 years) with randomly allocated period: 129 +5 between low sodium – serum (1987), mild to start on one of mmHg diet to normal sodium cholesterol over hypertension three cross-over diet (assuming that the Low sodium period: study (SBP > arms: potassium group was 140mmHg, excluded by Graudal, 57 + 5 mmHg [] 1. Low sodium diet DBP> 90mmHg) although this is not plus sodium Low sodium/high clearly stated): supplementation potassium: 69 + 6 (90mmol/day) SBP: -0.8mmHg (SEM: mmHg 1.51, CI: -3.76, 2.61) 2. Low sodium diet (p<0.005) plus potassium DBP: -0.8mmHg (SEM: supplementation 1.44, CI: -3.62, 2.02) (72mmol/day) Cholesterol: 0.0 mg/dL 3. Low sodium diet (CI: -15.31, 15.31) plus placebo data from Graudal, does not appear to be based on change Key features for bias assessment of randomised trials
Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size duration Compliance to sodium target (urinary data) Results Grobbee et al. (1987), [] study II adults (18 – 28 years) with mild hypertension (SBP > 140mmHg, DBP> 90mmHg) Participants randomly allocated to start on one of three cross-over arms: 1. Low sodium diet plus sodium supplementation (90mmol/day) 2. Low sodium diet plus potassium supplementation (72mmol/day) 3. Low sodium diet plus placebo Blood pressure (supine), serum cholesterol 40 6 weeks Normal sodium period: 129 +5 mmHg Low sodium period: 57 + 5 mmHg Low sodium/high potassium: 69 + 6 mmHg (p<0.005) Mean difference between low sodium diet to normal sodium diet (assuming that the potassium group was excluded by Graudal, although this is not clearly stated): SBP: -0.8mmHg (SEM: 1.51, CI: -3.76, 2.61) DBP: -0.8mmHg (SEM: 1.44, CI: -3.62, 2.02) Cholesterol: 0.0 mg/dL (CI: -15.31, 15.31) data from Graudal, does not appear to be based on change Key features for bias assessment of randomised trials over
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