DASH II Adults (22 Participants SBP (primary 390 30 days Control diet: Mean difference between outcome), DBP 2001 and older), consumed a high low sodium period and Low sodium (BP measured normotensive sodium normal sodium period seated), serum - Sacks et diet: 64 + and (150mmol/day) (intermediate period) total al. (2001) 37mmol/24hr study hypertensive control diet for a 2 cholesterol, Control diet: (SBP: 120 week run-in – HDL and LDL - Vollmer Normal sodium 159mmHg, DBP: period. They were et al. diet SBP: (CI: -5.9, -3.2) 80 95mmHg) then randomised – (2001) (Intermediate DBP: -2.4mmHg (CI: -3.3, to either a control dietary period): - Harsha diet (usual USA 106 + 44 et al. style diet) or mmol/24hr DASH diet: (2004) DASH. Participants DASH diet: in both diet groups SBP: (CI: -3.0, -0.4) USA were then Low sodium DBP: -1.0mmHg (CI: -1.9, randomised to [, , ] diet: 67 + start one of three 46mmol/24hr cross-over arms: Control diet: Normal sodium 1. Low sodium Cholesterol: 0.07mmol/L (CI: diet (50mmol/day) plus -0.02, 0.15) (Intermediate DASH or control dietary period): diet HDL: -0.01mmol/L (CI: -0.03, 107 + 52 0.01) mmol/24hr 2. Intermediate sodium LDL: 0.07mmol/L (CI: 0.00, (100mmol/day) 0.15) plus DASH or DASH diet: control diet
DASH 2001 - Sacks et al. (2001) - Vollmer et al. (2001) - Harsha et al. (2004) USA [, , ] study II Adults (22 and older), normotensive and hypertensive (SBP: 120 – 159mmHg, DBP: 80 – 95mmHg) Participants consumed a high sodium (150mmol/day) control diet for a 2 week run-in period. They were then randomised to either a control diet (usual USA style diet) or DASH. Participants in both diet groups were then randomised to start one of three cross-over arms: 1. Low sodium (50mmol/day) plus DASH or control diet 2. Intermediate sodium (100mmol/day) plus DASH or control diet SBP (primary outcome), DBP (BP measured seated), serum total cholesterol, HDL and LDL 390 30 days Control diet: Low sodium diet: 64 + 37mmol/24hr Normal sodium diet (Intermediate dietary period): 106 + 44 mmol/24hr DASH diet: Low sodium diet: 67 + 46mmol/24hr Normal sodium diet (Intermediate dietary period): 107 + 52 mmol/24hr Mean difference between low sodium period and normal sodium period (intermediate period) Control diet: SBP: (CI: -5.9, -3.2) DBP: -2.4mmHg (CI: -3.3, DASH diet: SBP: (CI: -3.0, -0.4) DBP: -1.0mmHg (CI: -1.9, Control diet: Cholesterol: 0.07mmol/L (CI: -0.02, 0.15) HDL: -0.01mmol/L (CI: -0.03, 0.01) LDL: 0.07mmol/L (CI: 0.00, 0.15) DASH diet:
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx