TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 7 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 8 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 10 6.1. Exposure Assessment 10 6.1.1. Occupational Exposure 10 6.1.2. Public Exposure 10 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity oral 16 – B.2. Acute toxicity dermal 16 – B.3. Irritation skin 17 – B.4. Irritation eye 17 – B.5. Skin sensitisation 18 B.6. Repeat dose toxicity 19 B.7. Repeat dose toxicity 20 B.8. Genotoxicity bacteria 22 – B.9. Genotoxicity 22 – in vitro B.10. Genotoxicity 23 in vitro – Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.2. Ecotoxicological Investigations 26 C.2.1. Acute toxicity to fish 26 C.2.2. Acute toxicity to aquatic invertebrates 27 C.2.3. growth inhibition test 28 C.2.4. Toxicity to marine benthic organisms 29 BIBLIOGRAPHY 30
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 7 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 8 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 10 6.1. Exposure Assessment 10 6.1.1. Occupational Exposure 10 6.1.2. Public Exposure 10 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity – oral 16 B.2. Acute toxicity – dermal 16 B.3. Irritation – skin 17 B.4. Irritation – eye 17 B.5. Skin sensitisation 18 B.6. Repeat dose toxicity 19 B.7. Repeat dose toxicity 20 B.8. Genotoxicity – bacteria 22 B.9. Genotoxicity – in vitro 22 B.10. Genotoxicity – in vitro 23 Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.2. Ecotoxicological Investigations 26 C.2.1. Acute toxicity to fish 26 C.2.2. Acute toxicity to aquatic invertebrates 27 C.2.3. growth inhibition test 28 C.2.4. Toxicity to marine benthic organisms 29 BIBLIOGRAPHY 30
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