added. The capacity to evaluate both cellular stress and live/dead assay after a specific exposure protocol allows pathologists to identify compounds sufficiently toxic as to not warrant further study. If you think about all of those advertisements on TV for pharmaceuticals, often liver failure is a common concern and something that patients are often presented with in terms of potential complciatons. Artificial livers however are very useful to identify overdose thresholds for potential drugs that are sufficiently toxic that it isn’t possible to evaluate directly. Explain why tissue engineered organs have lagged the more widespread use of transplants. Solution: The allure of a transplanted organ that looks, smells, and feels just like the failed organ is really appealing. If the complications associated with trying to replicate the metabolic potential of organs that secrete any number of important and vital proteins are stark, its also worth noting that the transplant teams already have a head start on any potential tissue engineered solution. The more complex the function of any organ in terms of metabolism and secretion, the more nuanced the requirements are to produce cellular engineering strategies capable of co-culturing multiple cell types in a mixed system. Its a lot easier to solve the donor/host issues by suppressing the immune function and inserting away. Perhaps the use of decellularized organs is a nice happy medium, but the stark reality is that none of these transplant options from originally viable organs are available in supplies capable of addressing a long donor list;
added. The capacity to evaluate both cellular stress and live/dead assay after a specific exposure protocol allows pathologists to identify compounds sufficiently toxic as to not warrant further study. If you think about all of those advertisements on TV for pharmaceuticals, often liver failure is a common concern and something that patients are often presented with in terms of potential complciatons. Artificial livers however are very useful to identify overdose thresholds for potential drugs that are sufficiently toxic that it isn’t possible to evaluate directly. Explain why tissue engineered organs have lagged the more widespread use of transplants. Solution: The allure of a transplanted organ that looks, smells, and feels just like the failed organ is really appealing. If the complications associated with trying to replicate the metabolic potential of organs that secrete any number of important and vital proteins are stark, its also worth noting that the transplant teams already have a head start on any potential tissue engineered solution. The more complex the function of any organ in terms of metabolism and secretion, the more nuanced the requirements are to produce cellular engineering strategies capable of co-culturing multiple cell types in a mixed system. Its a lot easier to solve the donor/host issues by suppressing the immune function and inserting away. Perhaps the use of decellularized organs is a nice happy medium, but the stark reality is that none of these transplant options from originally viable organs are available in supplies capable of addressing a long donor list;
Solution-set-complete7-26.docx