He et al. II Caucasian, Following Blood pressure 169 (n=71 6 weeks All participants: Mean difference (sitting after 5 (2009), African and consuming a Caucasian, between low sodium Normal sodium 10 min rest), – UK Caribbean and reduced salt diet n=29 diet to normal 24hr period: 165 +58 Asian adults (30 (with a goal of Asian, sodium diet: ambulatory BP [] mmHg study 75 years), with 85mmol/day) for 2 n=69 – Seated: mild weeks, African Low sodium period: hypertension participants were and 110 + 49 mmHg Caucasian pts. (SBP: 140 randomly – (p<0.001) SBP: -4.8mmHg 170mmHg, DBP: allocated to start ) (SEM: 1.24, CI: -7.23, 90 105mmHg) one of the two – Caucasian pts. -2.37) cross-over arms: Normal sodium DBP: -2.2mmHg 1. Reduced salt period: 163 +54 (SEM: 0.66, CI: -3.49, diet with sodium mmHg -0.91) supplementation (90mmol/day) Low sodium period: Asian pts. 104 + 54 mmHg 2. Reduced salt SBP: -5.40mmHg diet with placebo (p<0.001) (SEM: 1.93, CI: -9.18, -1.62) Asian pts. DBP: -2.2mmHg Normal sodium (SEM: 1.04, CI: -4.24, period: 176 + 64 -0.16) mmHg African and Low sodium period: Caribbean pts. 108 + 49 mmHg (p<0.001)
He et al. (2009), UK [] study II Caucasian, African and Caribbean and Asian adults (30 – 75 years), with mild hypertension (SBP: 140 – 170mmHg, DBP: 90 – 105mmHg) Following consuming a reduced salt diet (with a goal of 85mmol/day) for 2 weeks, participants were randomly allocated to start one of the two cross-over arms: 1. Reduced salt diet with sodium supplementation (90mmol/day) 2. Reduced salt diet with placebo Blood pressure (sitting after 5 – 10 min rest), 24hr ambulatory BP 169 (n=71 Caucasian, n=29 Asian, n=69 African and 6 weeks All participants: Normal sodium period: 165 +58 mmHg Low sodium period: 110 + 49 mmHg (p<0.001) Caucasian pts. Normal sodium period: 163 +54 mmHg Low sodium period: 104 + 54 mmHg (p<0.001) Asian pts. Normal sodium period: 176 + 64 mmHg Low sodium period: 108 + 49 mmHg (p<0.001) Mean difference between low sodium diet to normal sodium diet: Seated: Caucasian pts. SBP: -4.8mmHg (SEM: 1.24, CI: -7.23, -2.37) DBP: -2.2mmHg (SEM: 0.66, CI: -3.49, -0.91) Asian pts. SBP: -5.40mmHg (SEM: 1.93, CI: -9.18, -1.62) DBP: -2.2mmHg (SEM: 1.04, CI: -4.24, -0.16) African and Caribbean pts. )
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