Life-saving 0·97 0·72, 1·32 0·844 Hospitalisation for 1·08 0·90, 1·31 0·407 worsening HF Direct CV death 2·59 1·54, 4·37 <0·001 Direct non-CV death 0·91 0·72; 1·24 0·780 CV after 1·57 1·01, 2·44 0·045 intervention Non-CV after 0·58 0·14, 2·30 0·433 intervention CV death after 0·94 0·72, 1·24 0·660 hospitalisation Non-CV after 1·26 0·58, 2·75 0·557 hospitalisation Censored 630 CV, cardiovascular; HF, heart failure. Associations between adaptive servo-ventilation therapy and hospitalisation for Table 4: worsening heart failure, adjusted for implantable cardioverter defibrillator (ICD), respiration (CSR) proportion at baseline and baseline left ventricular ejection fraction (LVEF). Significant interactions are reported. p-value for Subgroup N (%) Hazard ratio 95% CI interaction CSR <20% 0·64 0·40, 1·02 237 (17·9) CSR 20-50% 1·31 0·92, 1·86 0·021 439 (33.1) CSR >50% 1·36 1·01, 1·83 490 (37·0) LVEF >36% 0·85 0·56, 1·30 486 (36·7) LVEF 31–36% 0·84 0·54, 1·32 0·039 243 (18·3) LVEF 1·38 1·02, 1·86 340 (25·7) ≤30% CI, confidence interval.
Life-saving 0·97 0·72, 1·32 0·844 Hospitalisation for worsening HF 1·08 0·90, 1·31 0·407 Direct CV death 2·59 1·54, 4·37 <0·001 Direct non-CV death 0·91 0·72; 1·24 0·780 CV after intervention 1·57 1·01, 2·44 0·045 Non-CV after intervention 0·58 0·14, 2·30 0·433 CV death after hospitalisation 0·94 0·72, 1·24 0·660 Non-CV after hospitalisation 1·26 0·58, 2·75 0·557 Censored 630 CV, cardiovascular; HF, heart failure. Table 4: Associations between adaptive servo-ventilation therapy and hospitalisation for worsening heart failure, adjusted for implantable cardioverter defibrillator (ICD), respiration (CSR) proportion at baseline and baseline left ventricular ejection fraction (LVEF). Significant interactions are reported. Subgroup N (%) Hazard ratio 95% CI p-value for interaction CSR <20% 237 (17·9) 0·64 0·40, 1·02 0·021 CSR 20-50% 439 (33.1) 1·31 0·92, 1·86 CSR >50% 490 (37·0) 1·36 1·01, 1·83 LVEF >36% 486 (36·7) 0·85 0·56, 1·30 0·039 LVEF 31–36% 243 (18·3) 0·84 0·54, 1·32 LVEF ≤30% 340 (25·7) 1·38 1·02, 1·86 CI, confidence interval.
SERVE-HF%20multi%20state%20model%20paper_LRM_revision2-HW%20MRC.docx