TONE II adults Participants were Blood 681 (BP data Median Differences in Mean difference pressure (60 80 randomised to one available for change in urinary between reduced – et (seated), parallel years) taking of two groups: n=142 : 29 sodium excretion sodium and control al. design 1 anti- African months between study groups: events (2001), 1.reduced sodium study hypertensive American groups: (as USA intake intervention African-American medication participants endpoint) (goal to achieve African-American participants: (SBP: and n=471 [] urinary sodium participants: <145mmHg, African SBP: -4.9mmHg (SEM: excretion of less DBP: American Women: -25 (95% 1.71, CI: -8.25, -1.55) than 80 mmol/L) <85mmHg) participants) CI: -47, DBP: -3mmHg (SEM: 1.2, 2. control (usual (23% African CI: -5.35, -0.65) lifestyle) (p=0.03) American) Non-African-American Anti-hypertensive Men: -41 (95% CI: participants: medication was -13)mmol/24hr withdrawn for all (p=0.007) SBP: -4.0mmHg (SEM: participants 90 1.01, CI: -5.98, -2.02) days (+ 14 days) DBP: -1.6mmHg (SEM: after the start of participants: 0.69, CI: -2.95, -0.25) the intervention. Resumption of Women: -28 (95% Cardiovascular events: anti-hypertensive CI: -41, medication, high Stroke: BP (190/110mmHg) (p<0.001) Reduced sodium: 1 or a cardiovascular (individual and event), Men: -54 (95% CI: clinical event were control: 2 (individual and -42)mmol/24hr treated as event), p>0.99 (p<0.001) endpoints.
TONE et al. (2001), USA [] parallel design study II adults (60 – 80 years) taking 1 anti- hypertensive medication (SBP: <145mmHg, DBP: <85mmHg) (23% African American) Participants were randomised to one of two groups: 1.reduced sodium intake intervention (goal to achieve urinary sodium excretion of less than 80 mmol/L) 2. control (usual lifestyle) Anti-hypertensive medication was withdrawn for all participants 90 days (+ 14 days) after the start of the intervention. Resumption of anti-hypertensive medication, high BP (190/110mmHg) or a cardiovascular clinical event were treated as endpoints. Blood pressure (seated), events (as endpoint) 681 (BP data available for n=142 African American participants and n=471 African American participants) Median 29 months Differences in change in urinary sodium excretion between study groups: African-American participants: Women: -25 (95% CI: -47, (p=0.03) Men: -41 (95% CI: -13)mmol/24hr (p=0.007) participants: Women: -28 (95% CI: -41, (p<0.001) Men: -54 (95% CI: -42)mmol/24hr (p<0.001) Mean difference between reduced sodium and control groups: African-American participants: SBP: -4.9mmHg (SEM: 1.71, CI: -8.25, -1.55) DBP: -3mmHg (SEM: 1.2, CI: -5.35, -0.65) Non-African-American participants: SBP: -4.0mmHg (SEM: 1.01, CI: -5.98, -2.02) DBP: -1.6mmHg (SEM: 0.69, CI: -2.95, -0.25) Cardiovascular events: Stroke: Reduced sodium: 1 (individual and event), control: 2 (individual and event), p>0.99 :
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