II Adults (mean For 4 weeks prior to the Blood 99 4 weeks Low sodium Mean difference pressure et al. age 51.6 years) study starting, period: 120.5 + between low sodium (seated after (1997), with mild to participants consumed an 68.9mmol/24hr period and normal 15 min rest), USA moderate ad libitum NaCl diet sodium period: total Normal sodium study essential cholesterol, [] period: 175.9 + SBP: -4.90mmHg hypertension Following this, over a 4 LDL, HDL 68.7 mmol/24hr (SEM: 1.23, CI: -7.31, (DBP: 95 week period, all – -2.49) 115mmHg) participants then received (p<0.0001) the required amount of DBP: (SEM: isradipine (2.5mg or 0.81, CI: -4.49, -1.31) 5mg/day) to maintain Total cholesterol: their DBP at <90mmHg. 8.20 mg/dL (CI: -2.89, Participants were 19.29) instructed to consume a low sodium diet (60 – HDL: 0.10 mg/dL 80mmol/24hr), and were 3.79, 3.99) randomised to start one of two study arms: LDL: 5.90 mg/dL (CI: 16.16) 1. Restricted sodium diet plus supplementary NaCl Lipid data from (100mmol/24hr) Graudal, does not appear to be based 2. 1. Restricted sodium on change diet plus placebo Key features for bias assessment of randomised trials
et al. (1997), USA [] study II Adults (mean age 51.6 years) with mild to moderate essential hypertension (DBP: 95 – 115mmHg) For 4 weeks prior to the study starting, participants consumed an ad libitum NaCl diet Following this, over a 4 week period, all participants then received the required amount of isradipine (2.5mg or 5mg/day) to maintain their DBP at <90mmHg. Participants were instructed to consume a low sodium diet (60 – 80mmol/24hr), and were randomised to start one of two study arms: 1. Restricted sodium diet plus supplementary NaCl (100mmol/24hr) 2. 1. Restricted sodium diet plus placebo Blood pressure (seated after 15 min rest), total cholesterol, LDL, HDL 99 4 weeks Low sodium period: 120.5 + 68.9mmol/24hr Normal sodium period: 175.9 + 68.7 mmol/24hr (p<0.0001) Mean difference between low sodium period and normal sodium period: SBP: -4.90mmHg (SEM: 1.23, CI: -7.31, -2.49) DBP: (SEM: 0.81, CI: -4.49, -1.31) Total cholesterol: 8.20 mg/dL (CI: -2.89, 19.29) HDL: 0.10 mg/dL 3.99) LDL: 5.90 mg/dL (CI: 16.16) Lipid data from Graudal, does not appear to be based on change Key features for bias assessment of randomised trials 3.79,
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