Nowson II Adults (aged 33 Participants Blood pressure 92 64weeks Low sodium period: Mean (clinic - seated et al. 74 years), received dietary 50.9 +4.1 difference – after a 5 min (2003), both advice to reduce pts. (data mmol/24hr between low rest, home – Australia normotensive dietary sodium (to on change in sodium period after 10 min Normal sodium study (n=92) (mean 50mmol/day) and outcomes and normal rest, and 24hr [] period: 138.7 + 4.0 SBP: to increase not given for sodium period ambulatory mmol/24hr 121.9mmHg, potassium intake hypertensive (NT pts. only): BP) mean DBP: (to a target of pts.) (p=0.001) Seated (office): 78.1mmHg) and 80mmol/day). hypertensive Participants were SBP: 0.4mmHg (n=16)(mean then randomly (SEM: 0.8, CI: SBP: allocated to start 1.17, 1.97) 151.7mmHg, one of the two DBP: 0.0mmHg mean DBP: cross-over arms: (SEM: 0.6, CI: 151.7mmHg, 1. reduced sodium 1.18) 85.7mmHg) diet plus 120mmol sodium supplements /day 2. reduced sodium diet plus placebo Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing Reporting Funding source randomisation concealment follow-up early for benefit all outcome where results required
Nowson et al. (2003), Australia [] study II Adults (aged 33 – 74 years), both normotensive (n=92) (mean SBP: 121.9mmHg, mean DBP: 78.1mmHg) and hypertensive (n=16)(mean SBP: 151.7mmHg, mean DBP: 151.7mmHg, 85.7mmHg) Participants received dietary advice to reduce dietary sodium (to 50mmol/day) and to increase potassium intake (to a target of 80mmol/day). Participants were then randomly allocated to start one of the two cross-over arms: 1. reduced sodium diet plus 120mmol sodium supplements /day 2. reduced sodium diet plus placebo Blood pressure (clinic - seated after a 5 min rest, home – after 10 min rest, and 24hr ambulatory BP) 92 pts. (data on change in outcomes not given for hypertensive pts.) 64weeks Low sodium period: 50.9 +4.1 mmol/24hr Normal sodium period: 138.7 + 4.0 mmol/24hr (p=0.001) Mean difference between low sodium period and normal sodium period (NT pts. only): Seated (office): SBP: 0.4mmHg (SEM: 0.8, CI: 1.97) DBP: 0.0mmHg (SEM: 0.6, CI: 1.18) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to follow-up Use of where required Ceasing early for benefit Reporting all outcome results Funding source 1.17,
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