100 mg/ 10 ml in a single dose vial 500 mg/ 50 ml in a single dose vial Calculating total volume: For RA patients administer Rituxan as 2-1000mg intravenous infusions separated by two For GPA patients administer Rituxan as intravenous infusions once weekly for four weeks. Utilize mixing table below for volume totals. Mixing table: BSA Rituxan Rituxan NS/D5W Total m2 mg ml ml ml 1.3 488 49 74 123 1.4 525 53 80 133 1.5 563 56 84 140 1.6 600 60 90 150 1.7 638 64 96 160 1.8 675 68 102 170 1.9 713 71 107 178 2.0 750 75 133 188 2.1 788 79 119 198 2.2 825 83 125 208 Preparation and Administration: Administer ordered antihistamines and corticosteroids in ordered doses, 30 mins. Prior to start of infusion. Withdraw a volume of 0.9%NaCl equal to the volume for Rituxan required for the patients’ dose from the infusion bag. Withdraw the amount of Rituxan for intravenous infusion from vial(s) and add slowly to the Sodium Chloride infusion bag. Gently invert the gab to mix. Administer the initial infusion beginning at a rate of 50 mg /hr and increasing by 50 mg/hr very 30 mins. to a maximum rate of 400 mg /hr in the absence of infusion toxicity. Subsequent infusions should be administered at a rate of 100mg /hr increasing by 100mg /hr every 30 mins. to a maximum rate of 400mg /hr in the absence of infusion toxicity. If particulates and discolorations are noted, the product should not be used. Documentation: Weight Vital signs pre infusion and every 30 mins until infusion completion and 30 mins. post infusion. Total dose administered Start and stop times of infusion Wastage if applicable
100 mg/ 10 ml in a single dose vial 500 mg/ 50 ml in a single dose vial Calculating total volume: For RA patients administer Rituxan as 2-1000mg intravenous infusions separated by two For GPA patients administer Rituxan as intravenous infusions once weekly for four weeks. Utilize mixing table below for volume totals. Mixing table: BSA m2 Rituxan mg Rituxan ml NS/D5W ml Total ml 1.3 488 49 74 123 1.4 525 53 80 133 1.5 563 56 84 140 1.6 600 60 90 150 1.7 638 64 96 160 1.8 675 68 102 170 1.9 713 71 107 178 2.0 750 75 133 188 2.1 788 79 119 198 2.2 825 83 125 208 Preparation and Administration: Administer ordered antihistamines and corticosteroids in ordered doses, 30 mins. Prior to start of infusion. Withdraw a volume of 0.9%NaCl equal to the volume for Rituxan required for the patients’ dose from the infusion bag. Withdraw the amount of Rituxan for intravenous infusion from vial(s) and add slowly to the Sodium Chloride infusion bag. Gently invert the gab to mix. Administer the initial infusion beginning at a rate of 50 mg /hr and increasing by 50 mg/hr very 30 mins. to a maximum rate of 400 mg /hr in the absence of infusion toxicity. Subsequent infusions should be administered at a rate of 100mg /hr increasing by 100mg /hr every 30 mins. to a maximum rate of 400mg /hr in the absence of infusion toxicity. If particulates and discolorations are noted, the product should not be used. Documentation: Weight Vital signs pre infusion and every 30 mins until infusion completion and 30 mins. post infusion. Total dose administered Start and stop times of infusion Wastage if applicable
Rituxan-REM.docx