(total 50mmol Changes in 50mmol Intermediate: sodium/day) standing BP also sodium/day arm: 155mmHg not able to be 49 (SEM: 8, CI: 34, (SEM: 3) 2. Restricted sodium calculated due 65) mmHg diet plus 70mmol NaCl DBP: to insufficient tablets/day and (p<0.001) data on baseline Low: 91mmHg placebos (total levels in paper Note: Groups 2 (SEM: 2) 100mmol sodium/day) and 3 used for Intermediate: 3. Restricted sodium analysis 95mmHg (SEM: diet plus 160mmol 2) NaCl tablets/day (total 200mmol sodium/day) In follow-up 1 year after study Note: Groups 1 and 3 completed, SBP used for analysis by was: 142mmHg Graudal (insufficient (SEM: 3), DBP data in paper to allow was: 87mmHg manual extraction for (SEM: 2). 24hr excel sheet) urinary sodium excretion was 54mmol/24hr (SEM: 7) Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing Reporting Funding source randomisation concealment early for benefit all
(total 50mmol sodium/day) 2. Restricted sodium diet plus 70mmol NaCl tablets/day and placebos (total 100mmol sodium/day) 3. Restricted sodium diet plus 160mmol NaCl tablets/day (total 200mmol sodium/day) Note: Groups 1 and 3 used for analysis by Graudal (insufficient data in paper to allow manual extraction for excel sheet) Changes in standing BP also not able to be calculated due to insufficient data on baseline levels in paper 50mmol sodium/day arm: 49 (SEM: 8, CI: 34, 65) mmHg (p<0.001) Note: Groups 2 and 3 used for analysis Intermediate: 155mmHg (SEM: 3) DBP: Low: 91mmHg (SEM: 2) Intermediate: 95mmHg (SEM: 2) In follow-up 1 year after study completed, SBP was: 142mmHg (SEM: 3), DBP was: 87mmHg (SEM: 2). 24hr urinary sodium excretion was 54mmol/24hr (SEM: 7) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to Use of Ceasing early for benefit Reporting all Funding source
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx