Meland II Adults (aged Participants were Blood pressure 16 8 weeks Low sodium period: Mean difference (seated after 3 et al. mean randomly 125 (95% CI: 104 between low sodium – min rest), total (1997), age:50) with allocated to start 146) mmol/24hr period and normal cholesterol, Norway mild to one of the two sodium period: HDL Normal sodium study moderate cross-over arms: [] period: 191 (95% SBP: -4mmHg (SEM: hypertension 1. Moderately CI: 159 223) 2.47, CI: -8.84, 0.84) – (mean SBP: reduced salt diet mmol/24hr 146mmHg, DBP: -3mmHg (SEM: with salt mean DBP: (not stated if 1.36, CI: -5.67, -0.33) supplementation 95mmHg) significantly (providing cholesterol: 0.0 different) 50mmol mg/dL (CI: -27.32, sodium/day) 27.32) 2. Moderately HDL: -3.80 mg/dL reduced salt diet 6.87) with placebo Lipid data from Graudal, however does not appear to be based on change Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing study Reporting Funding source randomisation concealment early for benefit all where outcome required results
Meland et al. (1997), Norway [] study II Adults (aged mean age:50) with mild to moderate hypertension (mean SBP: 146mmHg, mean DBP: 95mmHg) Participants were randomly allocated to start one of the two cross-over arms: 1. Moderately reduced salt diet with salt supplementation (providing 50mmol sodium/day) 2. Moderately reduced salt diet with placebo Blood pressure (seated after 3 min rest), total cholesterol, HDL 16 8 weeks Low sodium period: 125 (95% CI: 104 – 146) mmol/24hr Normal sodium period: 191 (95% CI: 159 – 223) mmol/24hr (not stated if significantly different) Mean difference between low sodium period and normal sodium period: SBP: -4mmHg (SEM: 2.47, CI: -8.84, 0.84) DBP: -3mmHg (SEM: 1.36, CI: -5.67, -0.33) cholesterol: 0.0 mg/dL (CI: -27.32, 27.32) HDL: -3.80 mg/dL 6.87) Lipid data from Graudal, however does not appear to be based on change Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to Use of where required Ceasing study early for benefit Reporting all outcome results Funding source
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