where outcome required results MacGregor Unclear risk (no Unclear risk Participants: 0% loss to Not required No (low risk) High risk Not stated et al. description of (method of low risk follow-up (low (low risk) (Mean (company (1989) method of concealment of risk) arterial supplied Providers: low sequence allocation not pressure capsules but no risk generation) described) measured indication of but results funding) – Outcome not unclear risk assessors: reported) unclear risk Summary table Citation Study Population Intervention Outcomes Sample size Intervention Compliance to Results & design level measured duration sodium target location of relevant to (urinary data) research question Mascioli II Adults (aged Following dietary Blood pressure 48 4 weeks Pooled values not Mean (seated) et al. instructions to given for urinary difference (1991), normotensive consume a sodium levels in between low USA (SBP: reduced salt diet both diets. sodium diet to study <150mmHg, for 8 weeks, Difference normal sodium [] DBP: 80 participants were between the diet: – 89mmHg) randomly normal sodium and SBP: allocated to start low sodium periods
where required outcome results MacGregor et al. (1989) Unclear risk (no description of method of sequence generation) Unclear risk (method of concealment of allocation not described) Participants: low risk Providers: low risk Outcome assessors: unclear risk 0% loss to follow-up (low risk) Not required (low risk) No (low risk) High risk (Mean arterial pressure measured but results not reported) Not stated (company supplied capsules but no indication of funding) – unclear risk Summary table Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results Mascioli et al. (1991), USA [] study II Adults (aged normotensive (SBP: <150mmHg, DBP: 80 – 89mmHg) Following dietary instructions to consume a reduced salt diet for 8 weeks, participants were randomly allocated to start Blood pressure (seated) 48 4 weeks Pooled values not given for urinary sodium levels in both diets. Difference between the normal sodium and low sodium periods Mean difference between low sodium diet to normal sodium diet: SBP:
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