Latin American and reviews found in the Caribbean Health first phase were more Science Literature than 2 years old). Database. Reference of - Reference lists of articles also reviewed articles also reviewed for additional studies for additional studies Inclusion - Adults (18 years or - Adults (16 years or -Individuals of all - Adults (16 trial and - Adults (16 years - Studies used FFQ, criteria older) with normal or older) ages with normal or older) with normal or and older) with 24-hr recall, food raised blood pressure - Randomised elevated blood elevated blood normal or elevated record or urinary - Random allocation controlled clinical pressure pressure blood pressure sodium excretion to either modestly trials - Randomised - Randomised - Included (included overnight reduced salt intake or - Studies which were controlled trials controlled trials randomised and spot urine with usual salt intake (ie designed to reduce allocating which compared controlled trials and appropriate control) sodium intake, with a participants to either reduced sodium prospective cohort validation) - Reduction in 24hr control group a low or high sodium intakes with usual or studies - RCTs, cohort, urinary sodium receiving either a diet higher intakes - Studies included a studies excretion must be placebo or no active - Estimation of - Healthy individuals quantitative measure - studies in all ages, within the range of intervention sodium intake by as well as those with of exposure (sodium health statuses, races 40 120mmol/24hr - Study duration of 24hr urinary sodium obesity, diabetes or intake) and compared and ethnicities – - Duration of salt over 6 months excretion (either by chronic this with an outcome included reduction must have 24hr measurement or nephrolithiasis of interest, or been for 4 or more estimated from a (kidney stones) compared groups weeks sample of at trial 8 - Co-interventions consuming different hours) allowed if they were levels of sodium - No restriction on identical in the - Healthy individuals study duration control and as well as those with intervention groups obesity, diabetes or - Duration of 4 trial chronic or more nephrolithiasis - Reduction of (kidney stones) sodium intake of - Duration of 1 year >40mmol/day in or more intervention - Reported on outcome of interest
Latin American and Caribbean Health Science Literature Database. - Reference lists of articles also reviewed for additional studies reviews found in the first phase were more than 2 years old). Reference of articles also reviewed for additional studies Inclusion criteria - Adults (18 years or older) with normal or raised blood pressure - Random allocation to either modestly reduced salt intake or usual salt intake (ie control) - Reduction in 24hr urinary sodium excretion must be within the range of 40 – 120mmol/24hr - Duration of salt reduction must have been for 4 or more weeks - Adults (16 years or older) - Randomised controlled clinical trials - Studies which were designed to reduce sodium intake, with a control group receiving either a placebo or no active intervention - Study duration of over 6 months -Individuals of all ages with normal or elevated blood pressure - Randomised controlled trials allocating participants to either a low or high sodium diet - Estimation of sodium intake by 24hr urinary sodium excretion (either by 24hr measurement or estimated from a sample of at 8 hours) - No restriction on study duration - Adults (16 and older) with normal or elevated blood pressure - Randomised controlled trials which compared reduced sodium intakes with usual or higher intakes - Healthy individuals as well as those with obesity, diabetes or chronic nephrolithiasis (kidney stones) - Co-interventions allowed if they were identical in the control and intervention groups - Duration of 4 or more - Reduction of sodium intake of >40mmol/day in intervention - Adults (16 years and older) with normal or elevated blood pressure - Included randomised controlled trials and prospective cohort studies - Studies included a quantitative measure of exposure (sodium intake) and compared this with an outcome of interest, or compared groups consuming different levels of sodium - Healthy individuals as well as those with obesity, diabetes or chronic nephrolithiasis (kidney stones) - Duration of 1 year or more - Reported on outcome of interest - Studies used FFQ, 24-hr recall, food record or urinary sodium excretion (included overnight and spot urine with appropriate validation) - RCTs, cohort, studies - studies in all ages, health statuses, races and ethnicities included trial trial trial
Sodium%20Supporting%20Document%201%20%20Systematic%20Literature%20Review.docx