Elimination rate constant from k10 — K10 the central compartment, also ke or kelim. Half-life for the elimination k10_Half-life — K10_HL process from the central compartment. Distribution rate constant from k12 (k13, etc.) — K12 the first to the second compartment, etc. Distribution rate constant from k21 (k31, etc.) — K21 the second to the first compartment, etc. Clearance, includes total Cl Cl_obs, Cl_F_obs — clearance. Clearance from the central Cl1 — CL compartment, Clapp or apparent clearance for IV groups. Clearance from the secondary Cl2 — CLD2 compartment. Apparent clearance of the central compartment, also Cl_F Cl1_F Cl_F (gavage) CL_F for gavage groups in models. Apparent clearance from the Cl2_F — CLD2_F secondary compartment. Volume of distribution for the central compartment, includes Vd and V, volume of V1 Vz_obs V1 distribution; Vz, apparent volume of distribution for NCA; and Vapp, apparent volume of distribution for IV studies. Volume of distribution for the V2 — V2 peripheral compartment. Volume of distribution at steady Vss Vss_obs, Vss_pred Vss state. Apparent volume of distribution for the central compartment, V1_F Vz_F_obs V1_F includes Vd_F, V_F (for oral groups), and Vc_F. Apparent volume of distribution V2_F — V2_F for the peripheral compartment. MRTINF_obs, MRT MRT Mean residence time MRTINF_pred Area under the plasma concentration versus time curve, AUC_0-T AUCall, AUClast — AUC, from time ti (initial) to tf (final).
k10 — K10 Elimination rate constant from the central compartment, also ke or kelim. k10_Half-life — K10_HL Half-life for the elimination process from the central compartment. k12 (k13, etc.) — K12 Distribution rate constant from the first to the second compartment, etc. k21 (k31, etc.) — K21 Distribution rate constant from the second to the first compartment, etc. Cl Cl_obs, Cl_F_obs — Clearance, includes total clearance. Cl1 — CL Clearance from the central compartment, Clapp or apparent clearance for IV groups. Cl2 — CLD2 Clearance from the secondary compartment. Cl1_F Cl_F (gavage) CL_F Apparent clearance of the central compartment, also Cl_F for gavage groups in models. Cl2_F — CLD2_F Apparent clearance from the secondary compartment. V1 Vz_obs V1 Volume of distribution for the central compartment, includes Vd and V, volume of distribution; Vz, apparent volume of distribution for NCA; and Vapp, apparent volume of distribution for IV studies. V2 — V2 Volume of distribution for the peripheral compartment. Vss Vss_obs, Vss_pred Vss Volume of distribution at steady state. V1_F Vz_F_obs V1_F Apparent volume of distribution for the central compartment, includes Vd_F, V_F (for oral groups), and Vc_F. V2_F — V2_F Apparent volume of distribution for the peripheral compartment. MRT MRTINF_obs, MRTINF_pred MRT Mean residence time AUC_0-T AUCall, AUClast — Area under the plasma concentration versus time curve, AUC, from time ti (initial) to tf (final).
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