Women who experience vaginal bleeding in pregnancy Study ref LoE N Aim/ methods Findings Comments III-2 3,431 Aim: To describe patterns of vaginal bleeding Vaginal bleeding during the first 20 () in the first 20 weeks of pregnancy and weeks was experienced by 780 (23%) evaluate the association between patterns women. Risk of pre-eclampsia was not of bleeding and risk of subsequent associated with the presence or in nulliparous women. absence of bleeding (aOR 0.96; 95% CI 0.67 to 1.38). Analyses confined to Methods: Participating centres of the women with vaginal bleeding showed Screening for Pregnancy Endpoints (SCOPE) that any bleeding episode of five or study in Auckland (New Zealand), Adelaide more consecutive days, compared with (Australia), Manchester and London (UK) and shorter episodes, increased risk of Cork (Ireland). Population. Healthy nulliparous approximately twofold (aOR women (n= 3431). Logistic regression was 2.15, 95% CI 1.01 to 4.57), as did multiple used to assess the association between compared with single episodes of bleeding characteristics and pre-eclampsia bleeding (aOR 2.33, 95%CI 1.16 to 4.67). while controlling for known determinants of pre-eclampsia.
Women who experience vaginal bleeding in pregnancy Study ref LoE N Aim/ methods Findings Comments () III-2 3,431 Aim: To describe patterns of vaginal bleeding in the first 20 weeks of pregnancy and evaluate the association between patterns of bleeding and risk of subsequent in nulliparous women. Methods: Participating centres of the Screening for Pregnancy Endpoints (SCOPE) study in Auckland (New Zealand), Adelaide (Australia), Manchester and London (UK) and Cork (Ireland). Population. Healthy nulliparous women (n= 3431). Logistic regression was used to assess the association between bleeding characteristics and pre-eclampsia while controlling for known determinants of pre-eclampsia. Vaginal bleeding during the first 20 weeks was experienced by 780 (23%) women. Risk of pre-eclampsia was not associated with the presence or absence of bleeding (aOR 0.96; 95% CI 0.67 to 1.38). Analyses confined to women with vaginal bleeding showed that any bleeding episode of five or more consecutive days, compared with shorter episodes, increased risk of approximately twofold (aOR 2.15, 95% CI 1.01 to 4.57), as did multiple compared with single episodes of bleeding (aOR 2.33, 95%CI 1.16 to 4.67).
Preeclampsia%20evaluation%20report%2016May17.docx