Y181C 74.7 95 98 87.5 G190A 80.2 96.1 98.4 88.9 V106M 81 97.6 98.9 93 K65R 81.9 98.5 99.3 97 LMICs, All Subtypes Total Total Children TDF (n=573) (n=3,282) (n=725) (n=291) 49.4 K103N 46.8 45 40.5 95.2 M184V 62.7 92 79 97.9 Y181C 76.1 95.6 87.6 98.3 G190A 81.7 96.7 89 98.9 V106M 82.9 98.4 95.9 99.3 K65R 83.9 99 99 All Regions, Subtype C Total Total Children TDF (n=157) (n=1,909) (n=473) (n=242) 56.7 K103N 45.9 51.1 38.8 96.2 M184V 56.7 92 75.6 97.5 Y181C 71.3 94.6 83.5 97.9 G190A 80.3 95.5 85.1 98.7 V106M 83.4 98.5 94.2 99.4 K65R 84.7 99.4 98.8 and ADR were defined as having one or more major DRMs. Major NRTI-associated DRMs aTDR (HIVDB score K65R, D67 deletion, T69 insertion, K70R, L74V/I, Y115F, Q151M, ≥30) included M184I/V, and T215F/Y. Major NNRTI-associated DRMs (HIVDB score included: L100I, K101P, ≥60) K103N/S, V106A/M, Y181C/I/V, Y188L/H/C, G190A/S/E/Q, and M230L.
Y181C 74.7 95 98 87.5 G190A 80.2 96.1 98.4 88.9 V106M 81 97.6 98.9 93 K65R 81.9 98.5 99.3 97 LMICs, All Subtypes Total (n=573) Total (n=3,282) Children (n=725) TDF (n=291) K103N 46.8 45 49.4 40.5 M184V 62.7 92 95.2 79 Y181C 76.1 95.6 97.9 87.6 G190A 81.7 96.7 98.3 89 V106M 82.9 98.4 98.9 95.9 K65R 83.9 99 99.3 99 All Regions, Subtype C Total (n=157) Total (n=1,909) Children (n=473) TDF (n=242) K103N 45.9 51.1 56.7 38.8 M184V 56.7 92 96.2 75.6 Y181C 71.3 94.6 97.5 83.5 G190A 80.3 95.5 97.9 85.1 V106M 83.4 98.5 98.7 94.2 K65R 84.7 99.4 99.4 98.8 aTDR and ADR were defined as having one or more major DRMs. Major NRTI-associated DRMs (HIVDB score ≥30) included K65R, D67 deletion, T69 insertion, K70R, L74V/I, Y115F, Q151M, M184I/V, and T215F/Y. Major NNRTI-associated DRMs (HIVDB score ≥60) included: L100I, K101P, K103N/S, V106A/M, Y181C/I/V, Y188L/H/C, G190A/S/E/Q, and M230L.
POC_DRMs.docx