Friday et al., 2009. Extremity injuries 10 cm colour In children presenting analogue (1 mg⁄ kg as to ED with moderate to codeine, maximum severely painful 60 mg) n=32 or extremity injuries, there ibuprofen (10 mg⁄ was adequate and kg, maximum 400 equivalent analgesia mg) n=34 with ibuprofen or the paracetamol−codeine combination. Note differences favour ibuprofen in the first 40 minutes and the combination at 1 hour. Results were not statistically significant based on 95% CI. Gatoulis et al., Third molar Pain Intensity Aspirin (1000 mg), Treatment with aspirin 2012. extraction or Difference on acetaminophen (300 (1000 mg) provides tension type verbal mg) + codeine (30 statistically significant headache rating scale mg), or placebo analgesia compared with placebo use and comparable efficacy with acetaminophen (300 mg) + codeine (30 mg) therapy after impacted third molar extraction and in tension- type headache. Hellman et al., Removal of lower VAS Two-dose The combination 1992. third molars regimen: ibuprofen-codeine had combination greater analgesic ibuprofen 200 mg + efficacy compared to codeine 30 mg was the combination compared with that acetylsalicylic of acetylsalicylic (P<0.005) or acid 500 mg + codeine in patients codeine 30 mg and with pain after removal codeine 30mg of the lower third molars. Madore et al., Post-operative Pain Intensity Fiorinal with Double dose of Fiorinal 1967. pain Difference on codeine was superior to the rating scale single dose. Matts et al., 1966. Recurring pain Sequential Panadeine Co Panadeine Co was Analysis Chart (paracetamol 1 g superior to soluble plus codeine aspirin in obtaining pain phosphate 16 mg) relief. vs soluble aspirin 1 g
Friday et al., 2009. Extremity injuries 10 cm colour analogue (1 mg⁄ kg as codeine, maximum 60 mg) n=32 or ibuprofen (10 mg⁄ kg, maximum 400 mg) n=34 In children presenting to ED with moderate to severely painful extremity injuries, there was adequate and equivalent analgesia with ibuprofen or the paracetamol−codeine combination. Note differences favour ibuprofen in the first 40 minutes and the combination at 1 hour. Results were not statistically significant based on 95% CI. Gatoulis et al., 2012. Third molar extraction or tension type headache Pain Intensity Difference on verbal rating scale Aspirin (1000 mg), acetaminophen (300 mg) + codeine (30 mg), or placebo Treatment with aspirin (1000 mg) provides statistically significant analgesia compared with placebo use and comparable efficacy with acetaminophen (300 mg) + codeine (30 mg) therapy after impacted third molar extraction and in tension- type headache. Hellman et al., 1992. Removal of lower third molars VAS Two-dose regimen: combination ibuprofen 200 mg + codeine 30 mg was compared with that of acetylsalicylic acid 500 mg + codeine 30 mg and codeine 30mg The combination ibuprofen-codeine had greater analgesic efficacy compared to the combination acetylsalicylic (P<0.005) or codeine in patients with pain after removal of the lower third molars. Madore et al., 1967. Post-operative pain Pain Intensity Difference on rating scale Fiorinal with codeine Double dose of Fiorinal was superior to the single dose. Matts et al., 1966. Recurring pain Sequential Analysis Chart Panadeine Co (paracetamol 1 g plus codeine phosphate 16 mg) vs soluble aspirin 1 g Panadeine Co was superior to soluble aspirin in obtaining pain relief.
review-efficacy-and-safety-over-counter-codeine-combination-medicines.docx