20 studies Aim: to assess the risk for PTB in women with treated and Compared to women with untreated CIN, () untreated cervical intraepithelial neoplasia (CIN). women treated for CIN before or during pregnancy, had overall a significantly higher risk Methods: We performed an electronic literature search in of PTB<37 weeks (OR 1.7, 95%CI 1.0 to 2.7). MEDLINE, Embase and CENTRAL for studies that reported on pregnancy outcome after treated and untreated CIN. Compared to women with untreated CIN, The methodological was scored using the STROBE women treated for CIN before pregnancy had combined checklist for observational studies. We an increased risk of preterm birth (OR 1.4, 95%CI extracted data on PTB<37 weeks, very PTB<32 weeks, 0.85 to 2.3). spontaneous PTB<37 weeks, (preterm) premature rupture Women treated during pregnancy had a clearly of membranes ((P)PROM), perinatal mortality and increased risk for PTB compared to women with caesarean each before and after treatment for CIN. We untreated CIN (OR 6.5, 95%CI 1.1 to 37). used the Mantel-Haenszel method to estimate In women with cervical surgery compared to summarizing odds ratios. Our search identified 620 studies, women with untreated CIN, the risks for of which 20 were reporting on pregnancy outcome for a spontaneous PTB<37 weeks (OR 0.87, 95% CI 0.54 total of 12,159,293 women. There were 20,832 women who to 1.4) was not increased. gave birth after treatment for CIN before pregnancy, 52 The increased risk of PTB in women who women who gave birth after treatment for CIN during underwent cervical surgery for CIN is especially pregnancy, 64,237 women with CIN who gave birth increased when performed during pregnancy. before treatment, and 8,902,865 women who gave birth When performed before pregnancy the risk of without CIN. PTB is increased, although insignificant.
() 20 studies Aim: to assess the risk for PTB in women with treated and untreated cervical intraepithelial neoplasia (CIN). Methods: We performed an electronic literature search in MEDLINE, Embase and CENTRAL for studies that reported on pregnancy outcome after treated and untreated CIN. The methodological was scored using the STROBE combined checklist for observational studies. We extracted data on PTB<37 weeks, very PTB<32 weeks, spontaneous PTB<37 weeks, (preterm) premature rupture of membranes ((P)PROM), perinatal mortality and caesarean each before and after treatment for CIN. We used the Mantel-Haenszel method to estimate summarizing odds ratios. Our search identified 620 studies, of which 20 were reporting on pregnancy outcome for a total of 12,159,293 women. There were 20,832 women who gave birth after treatment for CIN before pregnancy, 52 women who gave birth after treatment for CIN during pregnancy, 64,237 women with CIN who gave birth before treatment, and 8,902,865 women who gave birth without CIN. Compared to women with untreated CIN, women treated for CIN before or during pregnancy, had overall a significantly higher risk of PTB<37 weeks (OR 1.7, 95%CI 1.0 to 2.7). Compared to women with untreated CIN, women treated for CIN before pregnancy had an increased risk of preterm birth (OR 1.4, 95%CI 0.85 to 2.3). Women treated during pregnancy had a clearly increased risk for PTB compared to women with untreated CIN (OR 6.5, 95%CI 1.1 to 37). In women with cervical surgery compared to women with untreated CIN, the risks for spontaneous PTB<37 weeks (OR 0.87, 95% CI 0.54 to 1.4) was not increased. The increased risk of PTB in women who underwent cervical surgery for CIN is especially increased when performed during pregnancy. When performed before pregnancy the risk of PTB is increased, although insignificant.
Preterm%20evaluation%20report%2021May17.docx