Study Country Sample Design Timeframe Population Median ART eligibility Exclusions Intervention Comparator CD4 at ART initiation, mm3 (IQR) Amanyire1 Uganda 12024 Cluster 2013-2015 Adults (>18 310 CD4 <350, None ART initiation Training and SoC (variable RCT years) WHO Stage within 14 days coaching, PoC but usual III/IV, of eligibility CD4, revised practice pregnancy, later determination counselling included 3 pre included key approach and treatment populations + (Same Day facility feedback counselling sdc + CD4 ART start was sessions, <500 reported as a requirement for secondary treatment endpoint) supporter, + overnight CD4 cell count processing); ART at 28 days (mean) Koening2 Haiti 703 RCT 2014-2016 Adults 248 CD4<500 Pregnancy, Same Day SoC (with the SoC= TB or ART (same exception of Counselling/ pneumonia; day as HIV ART start social worker failure to diagnosis) timing) visits1 demonstrate Chest x-ray and transportation subsidy ART at day 21 Rosen3 South Africa 463 RCT 2013-2014 Adults (>18 Median: CD4 <350 or Pregnancy Same Day PoC CD4, rapid ART at visit 6 (377 years) <200 WHO Stage ART (first TB test and (2-4 weeks post eligible III/IV HIV-related PoC baseline visit 1; mean 22 for Rapid arm: clinical visit) blood tests days, Mean 22 ART) 224 Group and days)2 individual Group and counseling as individual SoC arm: per SoC also counseling 195 provided but condensed version provided all on same day Labhardt4 Lesotho 276 Cluster -2017 Adults (>18 380 Treat All Pregnant or Same Day Home-based Post-test RCT years) breast-feeding, ART (same HIV testing counselling and already day as HIV referral to enrolled in care diagnosis) nearest for another clinic chronic disease, clinical WHO stage 4 or active tuberculosis, or
Study Country Sample Design Timeframe Population Median CD4 at ART initiation, mm3 (IQR) ART eligibility Exclusions Intervention Comparator Amanyire1 Uganda 12024 Cluster RCT 2013-2015 Adults (>18 years) 310 CD4 <350, WHO Stage III/IV, pregnancy, later included key populations + sdc + CD4 <500 None ART initiation within 14 days of eligibility determination (Same Day ART start was reported as a secondary endpoint) Training and coaching, PoC CD4, revised counselling approach and facility feedback SoC (variable but usual practice included 3 pre treatment counselling sessions, requirement for treatment supporter, + overnight CD4 cell count processing); ART at 28 days (mean) Koening2 Haiti 703 RCT 2014-2016 Adults 248 CD4<500 Pregnancy, TB or pneumonia; failure to demonstrate Same Day ART (same day as HIV diagnosis) SoC (with the exception of ART start timing) Chest x-ray SoC= Counselling/ social worker visits1 and transportation subsidy ART at day 21 Rosen3 South Africa 463 (377 eligible for ART) RCT 2013-2014 Adults (>18 years) Median: <200 Rapid arm: 224 SoC arm: 195 CD4 <350 or WHO Stage III/IV Pregnancy Same Day ART (first HIV-related clinical visit) PoC CD4, rapid TB test and PoC baseline blood tests Group and individual counseling as per SoC also provided but condensed version provided all on same day ART at visit 6 (2-4 weeks post visit 1; mean 22 days, Mean 22 days)2 Group and individual counseling Labhardt4 Lesotho 276 Cluster RCT -2017 Adults (>18 years) 380 Treat All Pregnant or breast-feeding, already enrolled in care for another chronic disease, clinical WHO stage 4 or active tuberculosis, or Same Day ART (same day as HIV diagnosis) Home-based HIV testing Post-test counselling and referral to nearest clinic
QAD_2017_10_12_FORD_AIDS-D-17-00709_SDC1.docx