Gerschman Copenhagen Temporomandibular I: 34.6 I: 14 Paracetamol 450 mg Placebo VAS 0-100 2 weeks (cross 1984 joint pain P: 29.7 P: 16 + codeine 9.75 mg 2 over study dysfunction tabs every 4 hours design) syndrome Giles 1986 Nottingham Postoperative I: 23.9 I: 36 Placebo 9 point pain 5 h Single dose study England dental pain P: 25.7 P: 35 Ibuprofen 200 mg + rating scale i.e. codeine 15 mg 0-8 Heidrich 1985 Washington Post-orthopaedic 31 years I: 40 Single dose trial Placebo VAS 0-100 6 h surgery patients across entire P: 40 Paracetamol 300 mg with moderate to cohort + codeine 30 mg severe pain. Quiding 1983 Sweden Post meniscectomy I: 33 (9.6) I: 16 Single dose study Placebo Pain intensity 6 h P: 38 (11.3) P:10 paracetamol 1000 mg Difference 0-10 + codeine 60 mg Skoglund Norway Post-surgery to I: 25 I: 37 Single dose study Placebo VAS 0-100 6 h 1991 remove impacted P: 24.4 P 33 paracetamol 1000 mg wisdom + codeine 60 mg Squires 1981 Canada Dental surgery pain I: 27.0 I: 30 Single dose study Placebo 9 point pain 4 h P: 28.7 P: 26 ASA-30 (Aspirin 375 rating scale i.e. mg + codeine 30 mg + 0-8 caffeine 30 mg) Quiding 1992 Sweden Coxarthrosis 53 I: 26 I (A): ibuprofen 200 Placebo 0-100 VAS 32 h P: 26 mg + codeine 30 mg M: 4 Six doses during 24 F: 22 hours Cough Trials Smith 2006 United in COPD 68.0 (6.86) 21 Codeine phosphate Placebo Cough 12 h (day and (cross-over Kindgdom I: 19 60 mg capsules and frequency night) design) P: 19 again after 12 hours (coughs/hour)
Gerschman 1984 Copenhagen Temporomandibular joint pain dysfunction syndrome I: 34.6 P: 29.7 I: 14 P: 16 Paracetamol 450 mg + codeine 9.75 mg 2 tabs every 4 hours Placebo VAS 0-100 2 weeks (cross over study design) Giles 1986 Nottingham England Postoperative dental pain I: 23.9 P: 25.7 I: 36 P: 35 Single dose study Ibuprofen 200 mg + codeine 15 mg Placebo 9 point pain rating scale i.e. 0-8 5 h Heidrich 1985 Washington Post-orthopaedic surgery patients with moderate to severe pain. 31 years across entire cohort I: 40 P: 40 Single dose Paracetamol 300 mg + codeine 30 mg Placebo VAS 0-100 6 h Quiding 1983 Sweden Post meniscectomy I: 33 (9.6) P: 38 (11.3) I: 16 P:10 Single dose study paracetamol 1000 mg + codeine 60 mg Placebo Pain intensity Difference 0-10 6 h Skoglund 1991 Norway Post-surgery to remove impacted wisdom I: 25 P: 24.4 I: 37 P 33 Single dose study paracetamol 1000 mg + codeine 60 mg Placebo VAS 0-100 6 h Squires 1981 Canada Dental surgery pain I: 27.0 P: 28.7 I: 30 P: 26 Single dose study ASA-30 (Aspirin 375 mg + codeine 30 mg + caffeine 30 mg) Placebo 9 point pain rating scale i.e. 0-8 4 h Quiding 1992 Sweden Coxarthrosis 53 I: 26 P: 26 M: 4 F: 22 I (A): ibuprofen 200 mg + codeine 30 mg Six doses during 24 hours Placebo 0-100 VAS 32 h Cough Trials Smith 2006 (cross-over design) United Kindgdom in COPD 68.0 (6.86) 21 I: 19 P: 19 Codeine phosphate 60 mg capsules and again after 12 hours Placebo Cough frequency (coughs/hour) 12 h (day and night) trial
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