PART 4 SUMMARY OF EVIDENCE – Provide an overview of all key journal articles or research published in the public domain related to the proposed service that is for your application (limiting these to the English language only). Please do not attach full text articles, this is just intended to be a summary. Type of of journal article or Short description of research (max 50 words)** Website link to journal Date of study research project (including article or research (if publication design* any identifier or study available) *** lead if relevant) Randomised Sentinel-node biopsy or nodal 1269 patients with an intermediate-thickness primary cutaneous 2006 1. observation in melanoma. melanoma were randomly assigned to wide excision and postoperative observation of regional lymph nodes with lymphadenectomy if nodal relapse occurred, or to wide excision and sentinel-node biopsy with immediate lymphadenectomy if nodal micrometastases were detected on biopsy. Randomised Final report of Sentinel-node biopsy, a minimally invasive procedure for 2014 2. biopsy versus nodal regional melanoma staging, was evaluated in a phase 3 trial in observation in melanoma 2001 patients with primary cutaneous melanomas Review Sentinel node biopsy in Review of controversies in patient selection and follow-up 2016 3. melanoma: Current treatment controversies addressed. Meta-analysis Sentinel node biopsy plus Although no significant survival difference was observed in four 4. wide local excision vs. wide of the six series, the pooling summary data from all the studies location excision alone for that deal with this issue suggested that SLNBx is associated with primary cutaneous melanoma: a significantly better outcome compared with WLEA for localized a systematic review and melanoma. Retrospective Clinicopathologic Predictors of Retrospective review of 1240 patients in the multi-institutional 2013 5. analysis Sentinel Node Metastasis Sentinel Lymph Node Working Group database from 1994 to in Thin Melanoma 2012 to determine factors predictive of sentinel lymph node (SLN) metastasis in thin melanoma.
PART 4 – SUMMARY OF EVIDENCE Provide an overview of all key journal articles or research published in the public domain related to the proposed service that is for your application (limiting these to the English language only). Please do not attach full text articles, this is just intended to be a summary. Type of study design* of journal article or research project (including any identifier or study lead if relevant) Short description of research (max 50 words)** Website link to journal article or research (if available) Date of publication *** 1. Randomised Sentinel-node biopsy or nodal observation in melanoma. 1269 patients with an intermediate-thickness primary cutaneous melanoma were randomly assigned to wide excision and postoperative observation of regional lymph nodes with lymphadenectomy if nodal relapse occurred, or to wide excision and sentinel-node biopsy with immediate lymphadenectomy if nodal micrometastases were detected on biopsy. 2006 2. Randomised Final report of biopsy versus nodal observation in melanoma Sentinel-node biopsy, a minimally invasive procedure for regional melanoma staging, was evaluated in a phase 3 trial in 2001 patients with primary cutaneous melanomas 2014 3. Review Sentinel node biopsy in melanoma: Current controversies addressed. Review of controversies in patient selection and follow-up treatment 2016 4. Meta-analysis Sentinel node biopsy plus wide local excision vs. wide location excision alone for primary cutaneous melanoma: a systematic review and Although no significant survival difference was observed in four of the six series, the pooling summary data from all the studies that deal with this issue suggested that SLNBx is associated with a significantly better outcome compared with WLEA for localized melanoma. 5. Retrospective analysis Clinicopathologic Predictors of Sentinel Node Metastasis in Thin Melanoma Retrospective review of 1240 patients in the multi-institutional Sentinel Lymph Node Working Group database from 1994 to 2012 to determine factors predictive of sentinel lymph node (SLN) metastasis in thin melanoma. 2013
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