anxiety Control: 2 mg/day for Rating Scale Intervention: anxiolytic) 28 days (HAM-A) Age: 44.0 Control: Lorazepam Clinical Global (13.4) Stressor: 41% (benzodiazepine) Impression Male: 38% family-related; Scale (CGI) 30% work Sheehan Control: related; 9% Disability Age: 42.0 health; 20% Scale (SDS) (13.1) other Social Male: 30% Adjustment Scale Etifoxine was found non-inferior (i.e. at least as effective) to the control, but a significantly higher percentage of the treatment group were classified as responders (72%) at the end of treatment compared to controls (56%). Both groups improved in CGI ratings, but etifoxine had a higher proportion of markedly improved individuals. SAS-SR and SDS scores improved comparably between groups with no significant differences. Stein RCT South African 100% Pharmacotherapy Intervention: Intervention: Three Hamilton N = 201 (2015) outpatients adjustment Etifoxine capsules per day for Anxiety disorder with 28 days (150mg/day) Rating Scale Intervention: anxiety anxiolytic) Control: Three (HAM-A)
Intervention: Age: 44.0 (13.4) Male: 38% Control: Age: 42.0 (13.1) Male: 30% anxiety Stressor: 41% family-related; 30% work related; 9% health; 20% other anxiolytic) Control: Lorazepam (benzodiazepine) Control: 2 mg/day for 28 days Rating Scale (HAM-A) Clinical Global Impression Scale (CGI) Sheehan Disability Scale (SDS) Social Adjustment Scale Etifoxine was found non-inferior (i.e. at least as effective) to the control, but a significantly higher percentage of the treatment group were classified as responders (72%) at the end of treatment compared to controls (56%). Both groups improved in CGI ratings, but etifoxine had a higher proportion of markedly improved individuals. SAS-SR and SDS scores improved comparably between groups with no significant differences. Stein (2015) RCT South African outpatients Intervention: 100% adjustment disorder with anxiety Pharmacotherapy Intervention: Etifoxine anxiolytic) Intervention: Three capsules per day for 28 days (150mg/day) Control: Three Hamilton Anxiety Rating Scale (HAM-A) N = 201
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