Specialist Working Group for Immunology Proposed changes to the Criteria for the clinical use of intravenous immunoglobulin in Australia, Second Edition ITEM CRITERIA FOR THE CLINICAL USE OF PROPOSED REVISIONS TO THE CRITERIA SWG RATIONALE FOR PROPOSED CHANGE INTRAVENOUS IMMUNOGLOBULIN IN (A) Administrative) AUSTRALIA, EDITION 2 (B) Progressive (C) Programmed Condition Condition name retained. Primary immunodeficiency diseases (PID) with Primary immunodeficiency diseases (PID) Name antibody deficiency with antibody deficiency This excludes: ; . Specialty Immunology Immunology Chapter 5 5 Specific In each case, a specific PID diagnosis must be Specific condition will be a mandatory field in Severe combined immunodeficiency Conditions established under the supervision of a specialist the ig system. IUIS criteria have been used to (SCID) clinical immunologist and the diagnosis must be capture diagnostic groups as specific conditions. Combined immunodeficiency generally advised for IVIg to be approved. Given that the full detail may be overwhelming less profound than SCID (e.g. thymoma) to prescribers, it is proposed that the major Combined immunodeficiency with subheadings would be used. (A) associated or syndromal features (e.g.Wiskott Aldrich syndrome; ataxia telangiectasia) Severe reduction in all Ig isotypes with decreased or absent B-cells (e.g.XLA def) Severe reduction in at least two Ig isotypes with low/normal B-cells (CVID) Severe reduction in serum IgG and IgA with normal/elevated IgM (e.g. CD40L def)
Specialist Working Group for Immunology Proposed changes to the Criteria for the clinical use of intravenous immunoglobulin in Australia, Second Edition ITEM CRITERIA FOR THE CLINICAL USE OF INTRAVENOUS IMMUNOGLOBULIN IN AUSTRALIA, EDITION 2 PROPOSED REVISIONS TO THE CRITERIA SWG RATIONALE FOR PROPOSED CHANGE (A) Administrative) (B) Progressive (C) Programmed Condition Name Primary immunodeficiency diseases (PID) with antibody deficiency This excludes: ; . Primary immunodeficiency diseases (PID) with antibody deficiency Condition name retained. Specialty Immunology Immunology Chapter 5 5 Specific Conditions In each case, a specific PID diagnosis must be established under the supervision of a specialist clinical immunologist and the diagnosis must be advised for IVIg to be approved. Severe combined immunodeficiency (SCID) Combined immunodeficiency generally less profound than SCID (e.g. thymoma) Combined immunodeficiency with associated or syndromal features (e.g.Wiskott Aldrich syndrome; ataxia telangiectasia) Severe reduction in all Ig isotypes with decreased or absent B-cells (e.g.XLA def) Severe reduction in at least two Ig isotypes with low/normal B-cells (CVID) Severe reduction in serum IgG and IgA with normal/elevated IgM (e.g. CD40L def) Specific condition will be a mandatory field in the ig system. IUIS criteria have been used to capture diagnostic groups as specific conditions. Given that the full detail may be overwhelming to prescribers, it is proposed that the major subheadings would be used. (A)
primary-immunodeficiency-diseases%28pid%29-with-antibody-deficiency_0.DOCX