I 107 studies Aim: to assess the published evidence concerning the The association of PSP with PTB varied with the () association between psychosocial stress (PSP) and PTB, dimensions and timing of PSP. Stronger highlighting established and hypothesized physiological associations were generally found in early pathways mediating this association. pregnancy, and most studies demonstrating positive results found moderate effect sizes (RR Method: The PubMed and Web of Science databases 1.2 to 2.1). Subjective perception of stress and were searched using the keywords 'psychosocial stress', pregnancy-related anxiety appeared to be the 'pregnancy', 'pregnancy stress', 'preterm', 'preterm birth', stress measures most closely associated with PTB. 'gestational age', 'anxiety', and 'social support'. I 23 studies Aim: To understand the effect of untreated depression on Untreated depression was associated with () neonatal outcomes. significantly increased risks of preterm birth (OR 25,663 1.56; 95%CI 1.25 to 1.94; 14 studies), with a trend women Methods: Searches of MEDLINE, EMBASE, PsycINFO, toward higher risks for exposure to more severe Cumulative Index to Nursing and Allied Health, Cochrane depression. Central Register of Controlled Trials, and Web of Science were conducted. Randomised and non-randomised While the odds of preterm birth almost doubled studies examining neonatal outcomes in women with in studies reporting conflicts of interest (ie with depression receiving neither pharmacological nor pharmaceutical industry support) (OR, 2.50; treatment compared with women 95%CI, 1.70-3.67; 5 studies; I2, 0%), studies not without depression were included. Data were pooled reporting such conflicts showed more moderate data using random-effects meta-analyses, heterogeneity results (OR, 1.34; 95%CI, 1.08-1.66; 9 studies; I2, quantified using the I2 statistic and explored with 30%). subgroup analyses by type of assessment of depression, severity, reported conflicts of interest, and study quality.
() I 107 studies Aim: to assess the published evidence concerning the association between psychosocial stress (PSP) and PTB, highlighting established and hypothesized physiological pathways mediating this association. Method: The PubMed and Web of Science databases were searched using the keywords 'psychosocial stress', 'pregnancy', 'pregnancy stress', 'preterm', 'preterm birth', 'gestational age', 'anxiety', and 'social support'. The association of PSP with PTB varied with the dimensions and timing of PSP. Stronger associations were generally found in early pregnancy, and most studies demonstrating positive results found moderate effect sizes (RR 1.2 to 2.1). Subjective perception of stress and pregnancy-related anxiety appeared to be the stress measures most closely associated with PTB. () I 23 studies 25,663 women Aim: To understand the effect of untreated depression on neonatal outcomes. Methods: Searches of MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health, Cochrane Central Register of Controlled Trials, and Web of Science were conducted. Randomised and non-randomised studies examining neonatal outcomes in women with depression receiving neither pharmacological nor treatment compared with women without depression were included. Data were pooled data using random-effects meta-analyses, heterogeneity quantified using the I2 statistic and explored with subgroup analyses by type of assessment of depression, severity, reported conflicts of interest, and study quality. Untreated depression was associated with significantly increased risks of preterm birth (OR 1.56; 95%CI 1.25 to 1.94; 14 studies), with a trend toward higher risks for exposure to more severe depression. While the odds of preterm birth almost doubled in studies reporting conflicts of interest (ie with pharmaceutical industry support) (OR, 2.50; 95%CI, 1.70-3.67; 5 studies; I2, 0%), studies not reporting such conflicts showed more moderate results (OR, 1.34; 95%CI, 1.08-1.66; 9 studies; I2, 30%).
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