Sequential testing/screening Study ref Design LoE N Aim/methods Results Comments Cohort III-2 2,433 Aim: To compare performance of While the multimarker algorithm had () multimarker algorithm, risk profiles and the lowest false negative rate, their sequential application in sequential application of prediction of preeclampsia and cardiovascular and metabolic risk determining potential intervention profiles in screen positives reduced targets. false positives by 26% and identified blood pressure and metabolic risk in Methods: Maternal characteristics, 49/54 (91%) women with subsequent ultrasound variables and serum preeclampsia as treatable risk factors. biomarkers were collected prospectively at first trimester. Univariate analysis identified preeclampsia associated variables followed by logistic regression analysis to determine the prediction rule. Combined characteristics of the cardiovascular, metabolic and the personal risk factors were compared to the multimarker algorithm and the sequential application of both methods.
Sequential testing/screening Study ref Design LoE N Aim/methods Results Comments () Cohort III-2 2,433 Aim: To compare performance of multimarker algorithm, risk profiles and their sequential application in prediction of preeclampsia and determining potential intervention targets. Methods: Maternal characteristics, ultrasound variables and serum biomarkers were collected prospectively at first trimester. Univariate analysis identified preeclampsia associated variables followed by logistic regression analysis to determine the prediction rule. Combined characteristics of the cardiovascular, metabolic and the personal risk factors were compared to the multimarker algorithm and the sequential application of both methods. While the multimarker algorithm had the lowest false negative rate, sequential application of cardiovascular and metabolic risk profiles in screen positives reduced false positives by 26% and identified blood pressure and metabolic risk in 49/54 (91%) women with subsequent preeclampsia as treatable risk factors.
Preeclampsia%20evaluation%20report%2016May17.docx