Q6 When in pregnancy should screening be carried out? Study ref Design LoE N Aim/methods Results Comments Nested III-2 98 PE Aim: to examine the association Second trimester associations were () each between preeclampsia and stronger than those in the first (e.g. matched biochemical markers, in matched first PAPP-A 2.45, p < 0.01). No to 5 and second trimester maternal serum associations were found that control samples. would provide important improvements in prediction. Method: Stored samples were available from 'integrated' Down syndrome screening. Population distribution parameters and within and between trimester correlations were derived for cases and controls for six markers, as well as in case subgroups. Q7 What are the benefits and risks of the predictive tests (eg PAPP-A) to identify women at risk of pre-eclampsia? See Q3 Q8 Should every woman be tested for proteinuria at every antenatal visit if blood pressure remains normal? No studies identified 2.2 Excluded studies for screening Background papers Background papers will inform revision of the narrative.
Q6 When in pregnancy should screening be carried out? Study ref Design LoE N Aim/methods Results Comments () Nested III-2 98 PE each matched to 5 control Aim: to examine the association between preeclampsia and biochemical markers, in matched first and second trimester maternal serum samples. Method: Stored samples were available from 'integrated' Down syndrome screening. Population distribution parameters and within and between trimester correlations were derived for cases and controls for six markers, as well as in case subgroups. Second trimester associations were stronger than those in the first (e.g. PAPP-A 2.45, p < 0.01). No associations were found that would provide important improvements in prediction. Q7 What are the benefits and risks of the predictive tests (eg PAPP-A) to identify women at risk of pre-eclampsia? See Q3 Q8 Should every woman be tested for proteinuria at every antenatal visit if blood pressure remains normal? No studies identified 2.2 Excluded studies for screening Background papers Background papers will inform revision of the narrative.
Preeclampsia%20evaluation%20report%2016May17.docx