Q2 What are the risk factors for developing pre-eclampsia? Study ref LoE N Aim/ methods Findings Comments I 92 studies Aim: To develop a practical evidence based The pooled relative risk for each risk () list of clinical risk factors that can be assessed factor significantly exceeded 1.0, 25,356,688 by a clinician at < 16 weeks' gestation to except for prior intrauterine growth pregnancies estimate a woman's risk of pre-eclampsia. restriction. Women with antiphospholipid antibody syndrome Methods: Systematic review and had the highest pooled rate of of cohort studies from PubMed and (17.3%, 95% confidence Embase databases, 2000-15. Cohort studies interval 6.8% to 31.4%). Those with prior with >1,000 participants that evaluated the pre-eclampsia had the greatest pooled risk of pre-eclampsia in relation to a common relative risk (8.4, 7.1 to 9.9). Chronic and generally accepted clinical risk factor hypertension ranked second, both in assessed at <16 weeks' gestation. Two terms of its pooled rate (16.0%, 12.6% to independent reviewers extracted data from 19.7%) and pooled relative risk (5.1, 4.0 included studies. A pooled event rate and to 6.5) of pre-eclampsia. Pregestational pooled relative risk for pre-eclampsia were diabetes (pooled rate 11.0%, 8.4% to calculated for each of 14 risk factors. 13.8%; pooled relative risk 3.7, 3.1 to 4.3), prepregnancy body mass index (BMI) >30 (7.1%, 6.1% to 8.2%; 2.8, 2.6 to 3.1), and use of assisted reproductive technology (6.2%, 4.7% to 7.9%; 1.8, 1.6 to 2.1) were other prominent risk factors.
Q2 What are the risk factors for developing pre-eclampsia? Study ref LoE N Aim/ methods Findings Comments () I 92 studies 25,356,688 pregnancies Aim: To develop a practical evidence based list of clinical risk factors that can be assessed by a clinician at < 16 weeks' gestation to estimate a woman's risk of pre-eclampsia. Methods: Systematic review and of cohort studies from PubMed and Embase databases, 2000-15. Cohort studies with >1,000 participants that evaluated the risk of pre-eclampsia in relation to a common and generally accepted clinical risk factor assessed at <16 weeks' gestation. Two independent reviewers extracted data from included studies. A pooled event rate and pooled relative risk for pre-eclampsia were calculated for each of 14 risk factors. The pooled relative risk for each risk factor significantly exceeded 1.0, except for prior intrauterine growth restriction. Women with antiphospholipid antibody syndrome had the highest pooled rate of (17.3%, 95% confidence interval 6.8% to 31.4%). Those with prior pre-eclampsia had the greatest pooled relative risk (8.4, 7.1 to 9.9). Chronic hypertension ranked second, both in terms of its pooled rate (16.0%, 12.6% to 19.7%) and pooled relative risk (5.1, 4.0 to 6.5) of pre-eclampsia. Pregestational diabetes (pooled rate 11.0%, 8.4% to 13.8%; pooled relative risk 3.7, 3.1 to 4.3), prepregnancy body mass index (BMI) >30 (7.1%, 6.1% to 8.2%; 2.8, 2.6 to 3.1), and use of assisted reproductive technology (6.2%, 4.7% to 7.9%; 1.8, 1.6 to 2.1) were other prominent risk factors.
Preeclampsia%20evaluation%20report%2016May17.docx