Table 4.1: PbB response in adults from occupational epidemiology studies a ^ ^ k ^ PbB (μg/dL) Male Liver? Blood? Female Nervous system? system? Kidneys? System Immune Cancer? Endocrine vascular Mutagenicity? Gastrointestinal reproduction? reproduction <5 hormone in ↓haemoglobin, ↑ 5-10 l response to activity? Auditory function m stress? k decrements? 10-15 15-20 Increased Subtle Endocrine chrom ↑ blood changes in function, aberration, haemoglobin, ↓ 20-30 pressure & immune reduced micronuclei, d activity heart rate g sperm i markers & SCE c h variability quality Slight Kidney ? Changes neurobehavioral e n dysfunction in levels of symptoms 30-40 (cognitive f adrenal axes deficits, Hormones peripheral q b neuropathy) Changes in g thyroid 40-50 hormone p levels Kidney 50-60 j lung? d Anaemia 60-80 Encephalopathy, >80 Nephropathy o neuropathy cramps
Table 4.1: PbB response in adults from occupational epidemiology studies a PbB (μg/dL) Nervous System ^ ^ Blood? Kidneys? Endocrine system? Immune system? Female reproduction? Male reproduction ^ Mutagenicity? Cancer? k Gastrointestinal Liver? <5 5-10 Auditory function decrements? k ↓haemoglobin, activity? l ↑ hormone in response to stress? m 10-15 15-20 20-30 Increased blood pressure & heart rate variability c ↓ haemoglobin, activity d Subtle changes in immune markers g Endocrine function, reduced sperm quality h ↑ chrom aberration, micronuclei, & SCE i 30-40 Slight neurobehavioral symptoms (cognitive deficits, peripheral neuropathy) b Kidney dysfunction e adrenal axes f Changes in levels of Hormones q ? n 40-50 Changes in thyroid hormone levels p g 50-60 Kidney lung? j 60-80 Anaemia d >80 Encephalopathy, neuropathy o Nephropathy cramps vascular
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