Cohort III-2 1,011 Aim: To explore major risk factors and Women with early onset () early prediction methods in the had significantly elevated pathogenesis of early onset hCG (P<0.001). Major risk factors were preeclampsia. pregestational BMI >24 (OR 3.649, 95%CI 1.600 to 8.321, P=0.002), history Methods: Prenatal screening was of hypertension, diabetes and performed in second trimester using nephritis (OR 55.724, 95%CI 8.223 to enzyme-linked immunosorbent assay 377.614, P<0.001), family history of and epidemiological correlation hypertension (OR 6.777, 95%CI 2.917 factors were obtained by telephone. to 15.742, P<0.001) and risk coefficient Predictive model of early onset for trisomy 21 (OR 3.688, 95%CI 1.013 preeclampsia was established and to 13.429, P=0.048). 0.792 (95 % CI evaluated by single and multiple factor 0.701–0.882). logistic analysis. 243 Aim: To develop a model for prediction Screening by maternal characteristics () of late preeclampsia based on (including BMI, woman's mother's maternal history and characteristics, history of PE, previous PE, and parity) MAP, and circulating levels of mRNA for (a priori risk) and MAP detected 46.8% the placenta- specific 1 (PLAC1) gene of all cases of late PE at a fixed FPR of in maternal plasma at 14–18 weeks. 10%. The addition of PLAC1 yielded a DR of 62.8% at the same level of FPR. Method: A Gaussian model was fitted PLAC1 alone yielded a DR of 30.2%. to the log distribution of the multiple of the median (log MoM) PLAC1 mRNA in the PE group and in the unaffected group. Likelihood ratios for log MoM of circulating levels of mRNA for the PLAC1 gene were used to combine the a priori risk from maternal characteristics with MAP to produce patient-specific risks for each case.
() Cohort III-2 1,011 Aim: To explore major risk factors and early prediction methods in the pathogenesis of early onset preeclampsia. Methods: Prenatal screening was performed in second trimester using enzyme-linked immunosorbent assay and epidemiological correlation factors were obtained by telephone. Predictive model of early onset preeclampsia was established and evaluated by single and multiple factor logistic analysis. Women with early onset had significantly elevated hCG (P<0.001). Major risk factors were pregestational BMI >24 (OR 3.649, 95%CI 1.600 to 8.321, P=0.002), history of hypertension, diabetes and nephritis (OR 55.724, 95%CI 8.223 to 377.614, P<0.001), family history of hypertension (OR 6.777, 95%CI 2.917 to 15.742, P<0.001) and risk coefficient for trisomy 21 (OR 3.688, 95%CI 1.013 to 13.429, P=0.048). 0.792 (95 % CI 0.701–0.882). () 243 Aim: To develop a model for prediction of late preeclampsia based on maternal history and characteristics, MAP, and circulating levels of mRNA for the placenta- specific 1 (PLAC1) gene in maternal plasma at 14–18 weeks. Method: A Gaussian model was fitted to the log distribution of the multiple of the median (log MoM) PLAC1 mRNA in the PE group and in the unaffected group. Likelihood ratios for log MoM of circulating levels of mRNA for the PLAC1 gene were used to combine the a priori risk from maternal characteristics with MAP to produce patient-specific risks for each case. Screening by maternal characteristics (including BMI, woman's mother's history of PE, previous PE, and parity) (a priori risk) and MAP detected 46.8% of all cases of late PE at a fixed FPR of 10%. The addition of PLAC1 yielded a DR of 62.8% at the same level of FPR. PLAC1 alone yielded a DR of 30.2%.
Preeclampsia%20evaluation%20report%2016May17.docx