controls. (Table 1-4) Recently, it has been estimated that GA accounts for 22% of patients that present with sporadic ataxia.() Table 1-5 Table 14 Prevalence of antigliadin antibodies in patients with idiopathic sporadic ataxia* Sporadic Familial Healthy Reference Ataxias (%) Ataxias (%) Controls (%) 3/24 (13) 0/23 (0) NP () 12/104 (12) NP 5% () 7/26 (27) 9/24 (38) NP () 4/24 (17) NP 2% () 13/98 (13) 1/15 (6) 5% () 6/32 (19) 63 (8-15) 6/73 (8) () 59/143 (41) 8/59 (14) 149/1200 (12) () 5/14 (36) 1/27 (4) 1/47 (2) () 12/33 (36) NP NP () * Based on previously published data.(). NP = (data) not provided. All of the studies have methodological flaws: almost all were retrospective and varied in their use or inclusion of control groups; different gold standards for the definition of study populations were used; independent and blinded assessments of biopsy samples or measurements of disease outcome were rarely performed; data were largely accrued from tertiary referral centres and were thus subjected to referral bias; and studies attempting to disprove the association had inadequate sample size.()
controls. (Table 1-4) Recently, it has been estimated that GA accounts for 22% of patients that present with sporadic ataxia.() Table 1-5 Table 14 Prevalence of antigliadin antibodies in patients with idiopathic sporadic ataxia* Sporadic Ataxias (%) Familial Ataxias (%) Healthy Controls (%) Reference 3/24 (13) 12/104 (12) 7/26 (27) 4/24 (17) 13/98 (13) 6/32 (19) 59/143 (41) 5/14 (36) 12/33 (36) 0/23 (0) NP 9/24 (38) NP 1/15 (6) 63 (8-15) 8/59 (14) 1/27 (4) NP NP 5% NP 2% 5% 6/73 (8) 149/1200 (12) 1/47 (2) NP () () () () () () () () () * Based on previously published data.(). NP = (data) not provided. All of the studies have methodological flaws: almost all were retrospective and varied in their use or inclusion of control groups; different gold standards for the definition of study populations were used; independent and blinded assessments of biopsy samples or measurements of disease outcome were rarely performed; data were largely accrued from tertiary referral centres and were thus subjected to referral bias; and studies attempting to disprove the association had inadequate sample size.()
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