III-2 120 Aim: to evaluate placental protein-13 There was a significant inverse () (PP-13) and pregnancy-associated correlation between PAPP-A and late plasma protein-A (PAPP-A) in first pre-eclampsia (p=0.003), with a trimester maternal serum, for predicting off value of 0.805 (ROC analysis area pre-eclampsia. under curve 0.751). There was a significant reverse correlation Methods: A prospective case-control between PAPP-A and early study included women with (p=0.02). There was no (n=30) and pregnant significant relationship between PP13 controls (n=90). Women with and early pre-eclampsia, nor with late were divided into two pre-eclampsia (p=0.7, p=0.6, subgroups: early (n=9) and late-onset respectively). It was concluded that (n=21), and PP-13 and PAPP-A levels neither of these markers can serve as were compared between the groups a sufficient and reliable screening test and the comparison of risks for of pre-eclampsia because of were calculated. inadequate sensitivity in the Turkish pregnant population. Cohort III-2 500 Aim: to find indicators with sufficient TNF-alpha cut-off value >14. pg/mL () positive predictive value. had a sensitivity of 67.8% and a specificity of 98% in predicting PE with Methods: Serum TNF-alpha and uterine PPV of 79.4% and NPV of 96.4%. Mean artery Doppler were measured at 11-13 uterine artery PI >1.7 had a 100% weeks in low-risk pregnant women. sensitivity and 84.4% specificity in predicting PE, with a PPV of 41.7% and NPV of 100%.
() III-2 120 Aim: to evaluate placental protein-13 (PP-13) and pregnancy-associated plasma protein-A (PAPP-A) in first trimester maternal serum, for predicting pre-eclampsia. Methods: A prospective case-control study included women with (n=30) and pregnant controls (n=90). Women with were divided into two subgroups: early (n=9) and late-onset (n=21), and PP-13 and PAPP-A levels were compared between the groups and the comparison of risks for were calculated. There was a significant inverse correlation between PAPP-A and late pre-eclampsia (p=0.003), with a value of 0.805 (ROC analysis area under curve 0.751). There was a significant reverse correlation between PAPP-A and early (p=0.02). There was no significant relationship between PP13 and early pre-eclampsia, nor with late pre-eclampsia (p=0.7, p=0.6, respectively). It was concluded that neither of these markers can serve as a sufficient and reliable screening test of pre-eclampsia because of inadequate sensitivity in the Turkish pregnant population. () Cohort III-2 500 Aim: to find indicators with sufficient positive predictive value. Methods: Serum TNF-alpha and uterine artery Doppler were measured at 11-13 weeks in low-risk pregnant women. TNF-alpha cut-off value >14. pg/mL had a sensitivity of 67.8% and a specificity of 98% in predicting PE with PPV of 79.4% and NPV of 96.4%. Mean uterine artery PI >1.7 had a 100% sensitivity and 84.4% specificity in predicting PE, with a PPV of 41.7% and NPV of 100%. off
Preeclampsia%20evaluation%20report%2016May17.docx