Age: 40.0 Control: Alprazolam capsules per day for Self-report for (11.8) Stressor: 39% (benzodiazepine) 28 days (1.5mg/day) the Male: 32% interpersonal, Assessment Control: (38%) of Adjustment Age: 38.9 work/school; Disorders (12.8) economic Male: 30% (12%); other (11%) Alprazolam improved outcomes on HAM-A significantly more than etifoxine at day 7 but at day 35 (one week discontinuation), etifoxine demonstrated non-inferiority compared with alprazolam on HAM-A measures. There were no significant differences at day 35 for other measures. There were more adverse events reported in the alprazolam group. Combined psychological and pharmacotherapy Ichitovkina Controlled Russian 60% with Psychological: Art Psychiatrist delivered - Adaptivity N = 199 et al. cohort combatants adjustment therapy, collective 14 days of inpatient multi-factorial (2014) recently disorder: 27% rehabilitation hypnosuggestion, treatment followed by personality returned from with depressed rational therapy, twice-weekly questionnaire assignment mood; 32% with family therapy outpatient treatment (MPQ) anxiety and Pharmacotherapy: for five weeks, Intervention: depressed Primarily SSRIs and consisting of Age: 40.0 (1.4) mood; 10% benzodiazepines
Age: 40.0 (11.8) Male: 32% Control: Age: 38.9 (12.8) Male: 30% Stressor: 39% interpersonal, (38%) work/school; economic (12%); other (11%) Control: Alprazolam (benzodiazepine) capsules per day for 28 days (1.5mg/day) Self-report for the Assessment of Adjustment Disorders Alprazolam improved outcomes on HAM-A significantly more than etifoxine at day 7 but at day 35 (one week discontinuation), etifoxine demonstrated non-inferiority compared with alprazolam on HAM-A measures. There were no significant differences at day 35 for other measures. There were more adverse events reported in the alprazolam group. Combined psychological and pharmacotherapy Ichitovkina et al. (2014) Controlled cohort Russian combatants recently returned from assignment Intervention: Age: 40.0 (1.4) 60% with adjustment disorder: 27% with depressed mood; 32% with anxiety and depressed mood; 10% rehabilitation Psychological: Art therapy, collective hypnosuggestion, rational therapy, family therapy Pharmacotherapy: Primarily SSRIs and benzodiazepines Psychiatrist delivered 14 days of inpatient treatment followed by twice-weekly outpatient treatment for five weeks, consisting of - Adaptivity multi-factorial personality questionnaire (MPQ) N = 199
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