In this task you will prepare acetone derivatives of carbohydrate (I) and D-mannose α-amino acid (II). L-cysteine Chemicals and Reagents D-Mannose Iodine, crystalline Anhydrous acetone Na2S2O3 solution, dilute Chloroform Na2SO4, calcined hydrochloride L-Cisteine Ninhydrine reagent (0.3 % sol-n of ninhydrine in n-butanol cont. 3% of sodium acetate) Table of Chemicals Compound State R-Ratings S-Provisions C6H12O6, Solid - 28 D-Mannose I2 Solid 20/21 50 23 25 61 CH3C(O)CH3 Liquid 11 36 66 67 2 9 16 26 Na2S2O3 Aqueous solution - 24/25 CHCl3 Liquid 22 38 40 48/20/22 2 36/37 Na2SO4 Solid - - C3H8NO2SCl, Solid 22 36/37/38 25 26 36/37/39 L-Cisteine hydrochloride C9H6O4, Ninhydrine Solution 22 36/37/38 26 28A 37/39 C4H9OH, n-butanol Liquid 10 22 37/38 41 67 2 7/9 13 26 37/39 46 CH3COONa Solution - - Equipment and Glassware Magnetic stirrer with heating Magnetic bar Glass beaker, 50 or 100 mL (2 ea.) Round-bottom flask, 50 mL Reflux condenser Laboratory stand with metal rings and clamps Thermometer Adding funnel Separating funnel Filter flask Porous glass filter (2 ea.) Shott’s Rotary evaporator Water- or vacuum pump Analytical balance (± ) Pipette pump Capillary for melting point determination (2-3 ea.)
In this task you will prepare acetone derivatives of carbohydrate D-mannose (I) and α-amino acid L-cysteine (II). Chemicals and Reagents D-Mannose Iodine, crystalline Anhydrous acetone Na2S2O3 solution, dilute Chloroform Na2SO4, calcined L-Cisteine hydrochloride Ninhydrine reagent (0.3 % sol-n of ninhydrine in n-butanol cont. 3% of sodium acetate) Table of Chemicals Compound State R-Ratings S-Provisions C6H12O6, D-Mannose Solid - 28 I2 Solid 20/21 50 23 25 61 CH3C(O)CH3 Liquid 11 36 66 67 2 9 16 26 Na2S2O3 Aqueous solution - 24/25 CHCl3 Liquid 22 38 40 48/20/22 2 36/37 Na2SO4 Solid - - C3H8NO2SCl, L-Cisteine hydrochloride Solid 22 36/37/38 25 26 36/37/39 C9H6O4, Ninhydrine Solution 22 36/37/38 26 28A 37/39 C4H9OH, n-butanol Liquid 10 22 37/38 41 67 2 7/9 13 26 37/39 46 CH3COONa Solution - - Equipment and Glassware Magnetic stirrer with heating Magnetic bar Glass beaker, 50 or 100 mL (2 ea.) Round-bottom flask, 50 mL Reflux condenser Laboratory stand with metal rings and clamps Thermometer Adding funnel Separating funnel Filter flask Porous Shott’s glass filter (2 ea.) Rotary evaporator Water- or vacuum pump Analytical balance (± ) Pipette pump Capillary for melting point determination (2-3 ea.)
Preparatory_problems_IChO_2013.docx