149.2±1.3b 151 1:2 139.3±2.1b 140 PVP-HPMCAS-PCM 105.5±2.0b 110 3:1 93.4±1.4b 101 1:1 83.4±1.3b 96 1:2 a Measured by MTDSC from raw materials b Measured by MTDSC using electrospun materials Table 2 ss-NMR results (T1 (1H) and (1H)) of the raw materials and blend formulations T1ρ with (25% w/w) and without paracetamol. Material T1(1H)(ms) T1ρ(1H)(ms) PVP 269 6.9 214.0 3.0 HPMCAS (LF) 93000 N/A Crystalline PCM PVP:HPMCAS 3:1 165.0 1.4 ± 0.3 10 ± 2.0 150.0 1.0 ± 0.3 5.9 ± 0.6 PVP:HPMCAS 1:1 PVP:HPMCAS 1:2 175.0 1.0 ± 0.2 5.5 ± 0.4 PCM PVP:HPMCAS 277.0 0.32 ± 0.09 3.1 ± 0.3 3:1 PCM PVP:HPMCAS 293.0 0.2 ± 0.04 2.5 ± 0.1 1:1 PCM PVP:HPMCAS 299.0 1.51 1:2
1:2 149.2±1.3b 139.3±2.1b 151 140 PVP-HPMCAS-PCM 3:1 1:1 1:2 105.5±2.0b 93.4±1.4b 83.4±1.3b 110 101 96 a Measured by MTDSC from raw materials b Measured by MTDSC using electrospun materials Table 2 ss-NMR results (T1 (1H) and T1ρ (1H)) of the raw materials and blend formulations with (25% w/w) and without paracetamol. Material T1(1H)(ms) T1ρ(1H)(ms) PVP 269 6.9 HPMCAS (LF) 214.0 3.0 Crystalline PCM 93000 N/A PVP:HPMCAS 3:1 165.0 1.4 ± 0.3 10 ± 2.0 PVP:HPMCAS 1:1 150.0 1.0 ± 0.3 5.9 ± 0.6 PVP:HPMCAS 1:2 175.0 1.0 ± 0.2 5.5 ± 0.4 PCM PVP:HPMCAS 3:1 277.0 0.32 ± 0.09 3.1 ± 0.3 PCM PVP:HPMCAS 1:1 293.0 0.2 ± 0.04 2.5 ± 0.1 PCM PVP:HPMCAS 1:2 299.0 1.51
PVP_HPMCAS_revised_0312.docx