The PARROT Dr. Steven To determine the safety and 15 2016 Industry efficacy of Fragmin to study: Phase IIIb Soroka, Dr. prevent clotting in the open label study Jo-Anne extracorporeal system to optimize the Wilson, Ms. during hemodialysis, when single bolus dose Susan Fleet Fragmin is administered of dalteparin according to the adjustable sodium for the dose regimen. prevention of clotting within the extracorporeal system during hemodialysis procedures for subjects with chornic renal insufficiency Effectiveness and Dr. Steven To determine, in real world 100 2016 Both clinical practice among cost of weekly Soroka, Dr. industry outpatient hemodialysis in Jo-Anne and patients with a CVC who hemodialysis Wilson, Dr. are at high risk of catheter patients at high Karthik malfunction, if use of rtPA risk of catheter Tennankore funded once per week compared to complications: Ms. Paula citrate as a locking solution Quality Assurance Mossop results in: 1) a reduction in Project of the the rate of rt-PA use for implementation treatment of catheter and evaluation of malfunction ; 2) a reduction the PreCLOT. in the rate of catheter-related bacteremia; 3) a reduction in the rate of radiological interventions for catheter malfunction ;and 4) a reduction in cost and hospitalizations Dr. Jo-Anne The objectives are to 800 HD, An Evaluation of Wilson, Dr. determine: 1) whether 50 hepatitis B Steven patients (matched for Vaccine Soroka,Dr. characteristics that have Seroconversion Karthik been shown to influence in Predialysis Tennankore, response rates to Hepatitis B Chronic Kidney Dr. Bryce vaccine) with CKD stages Disease and Kiberd, Dr. (predialysis) have better Hemodialysis Shelly seroconversion rates Patients: A MacNeil, compared to hemodialysis
The PARROT study: Phase IIIb open label study to optimize the single bolus dose of dalteparin sodium for the prevention of clotting within the extracorporeal system during hemodialysis procedures for subjects with chornic renal insufficiency Dr. Steven Soroka, Dr. Jo-Anne Wilson, Ms. Susan Fleet To determine the safety and efficacy of Fragmin to prevent clotting in the extracorporeal system during hemodialysis, when Fragmin is administered according to the adjustable dose regimen. 15 2016 Industry Effectiveness and cost of weekly in hemodialysis patients at high risk of catheter complications: Quality Assurance Project of the implementation and evaluation of the PreCLOT. Dr. Steven Soroka, Dr. Jo-Anne Wilson, Dr. Karthik Ms. Paula Mossop To determine, in real world clinical practice among outpatient hemodialysis patients with a CVC who are at high risk of catheter malfunction, if use of rtPA once per week compared to citrate as a locking solution results in: 1) a reduction in the rate of rt-PA use for treatment of catheter malfunction ; 2) a reduction in the rate of catheter-related bacteremia; 3) a reduction in the rate of radiological interventions for catheter malfunction ;and 4) a reduction in cost and hospitalizations 100 2016 Both industry and funded An Evaluation of hepatitis B Vaccine Seroconversion in Predialysis Chronic Kidney Disease and Hemodialysis Patients: A Dr. Jo-Anne Wilson, Dr. Steven Soroka,Dr. Karthik Tennankore, Dr. Bryce Kiberd, Dr. Shelly MacNeil, The objectives are to determine: 1) whether patients (matched for characteristics that have been shown to influence response rates to Hepatitis B vaccine) with CKD stages (predialysis) have better seroconversion rates compared to hemodialysis 800 HD, 50 Tennankore
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