(Intervention C) 5h 2.56 0-8 2.28 32 (22.2) -3.5 (-15.0, 8.0) No 0-100 28.5 (22.2) 32 26 Frame Ibuprofen 400 mg + codeine 30 mg (Intervention D) 3 h 3.42 0-8 2.21 42.75 (22.2) 0-100 27.6 (22.2) 33 26 -15.2 (-26.6, -3.8) Yes 2.56 (Intervention D) 5 h 32 (22.2) 0-8 1.66 26 -11.2 (-22.6, 0.2) Yes 0-100 20.8 (22.2) 33 third molar – Ibuprofen 800 mg + codeine 60 mg 3.42 (Intervention E) 3h 42.75 (22.2) 0-8 1.96 26 26 -18.3 (-30.4, -6.2) Yes 0-100 24.5 (22.2) 2.56 32 (22.2) (Intervention E) 5 h 0-8 2.22 -4.2 (-16.3, 7.9) No 0-100 27.8 (22.2) 26 26 Median SD value used Quiding 1992 Median SD value used Ibuprofen + codeine Mean VAS 1-8 h after first dose 25 (22.2) 26 26 (22.2) 26 -1.0 (-13.1, 11.1) No 0-8 h after 6th dose 10 (22.2) 26 29 (22.2) 25 -19.0 (-31.2, -6.8) Yes
(Intervention C) 5h 0-8 0-100 Frame Ibuprofen 400 mg + codeine 30 mg (Intervention D) 3 h 0-8 0-100 (Intervention D) 5 h 0-8 0-100 – third molar Ibuprofen 800 mg + codeine 60 mg (Intervention E) 3h 0-8 0-100 (Intervention E) 5 h 0-8 0-100 Median SD value used 2.28 28.5 (22.2) 2.21 27.6 (22.2) 1.66 20.8 (22.2) 1.96 24.5 (22.2) 2.22 27.8 (22.2) 32 33 33 26 26 2.56 32 (22.2) 3.42 42.75 (22.2) 2.56 32 (22.2) 3.42 42.75 (22.2) 2.56 32 (22.2) 26 26 26 26 26 -3.5 (-15.0, 8.0) -15.2 (-26.6, -3.8) -11.2 (-22.6, 0.2) -18.3 (-30.4, -6.2) -4.2 (-16.3, 7.9) No Yes Yes Yes No Quiding 1992 Median SD value used Ibuprofen + codeine Mean VAS 1-8 h after first dose 0-8 h after 6th dose 25 (22.2) 10 (22.2) 26 26 26 (22.2) 29 (22.2) 26 25 -1.0 (-13.1, 11.1) -19.0 (-31.2, -6.8) No Yes
review-efficacy-and-safety-over-counter-codeine-combination-medicines.docx