Squires 1981 (dental surgery) (ASA 375mg + codeine 30mg + caffeine 30 1.2 1.9 mg) 9 point rating scale 15 (20) 30 23.8 (16.3) 26 -8.8 (-18.31, 0.71) No PID 3h SD converted and used from baseline Quiding 1983 Single dose of paracetamol 1000 mg codeine 60 mg Mean PI (over 4 h) 44 (13.6) 16 51 (24.4) 10 -7.0 (-23.53, 9.53) No Gerschman 1984 Paracetamol 450 mg + codeine 9.75 mg (2 tabs 4 hourly) _end of treatment Mean Difference in -45.4 (24.8) 14 -19.4 (27.0) 16 -26.0 (-44.54, -7.46) Yes Pain VAS 0-100 Cater 1985 Ibuprofen 400 mg + codeine 30 mg 3h 0-8 2.4 46 3.2 47 -10.00 (-19.0, -1.0) No 0-100 30 (22.2) 40 (22.2) 6h 0-8 2.8 46 3.3 47 -6.3 (-15.3, 2.7) No 0-100 35 (22.2) 41.3 (22.2) 8 h 0-8 3.5 3.2 0-100 43.8 (22.2) 46 40 (22.2) 47 3.80 (-5.2, 12.8) No Median SD value used Frame (1986) Ibuprofen 200 mg + codeine 15 mg 9 point rating scale (Intervention C) 3h 0-8 2.43 3.42 Yes 0-100 30.38 (22.2) 32 42.75 (22.2) 26 -12.4 (-23.9, -0.9)
Squires 1981 (dental surgery) (ASA 375mg + codeine 30mg + caffeine 30 mg) 9 point rating scale PID 3h SD converted and used from baseline 1.2 15 (20) 30 1.9 23.8 (16.3) 26 -8.8 (-18.31, 0.71) No Quiding 1983 Single dose of paracetamol 1000 mg codeine 60 mg Mean PI (over 4 h) 44 (13.6) 16 51 (24.4) 10 -7.0 (-23.53, 9.53) No Gerschman 1984 Paracetamol 450 mg + codeine 9.75 mg (2 tabs 4 hourly) _end of treatment Mean Difference in Pain VAS 0-100 -45.4 (24.8) 14 -19.4 (27.0) 16 -26.0 (-44.54, -7.46) Yes Cater 1985 Ibuprofen 400 mg + codeine 30 mg 3h 0-8 0-100 6h 0-8 0-100 8 h 0-8 0-100 Median SD value used 2.4 30 (22.2) 2.8 35 (22.2) 3.5 43.8 (22.2) 46 46 46 3.2 40 (22.2) 3.3 41.3 (22.2) 3.2 40 (22.2) 47 47 47 -10.00 (-19.0, -1.0) -6.3 (-15.3, 2.7) 3.80 (-5.2, 12.8) No No No Frame (1986) Ibuprofen 200 mg + codeine 15 mg 9 point rating scale (Intervention C) 3h 0-8 0-100 2.43 30.38 (22.2) 32 3.42 42.75 (22.2) 26 -12.4 (-23.9, -0.9) Yes
review-efficacy-and-safety-over-counter-codeine-combination-medicines.docx