I 11 studies Aim: to determine whether there is a higher Oocyte donation is a risk factor for the () incidence of preeclampsia (PE) in development of PE compared to IVF pregnancies achieved by oocyte donation cycles, with a weighted OR of 3.12 (OD) compared with pregnancies achieved under a fixed effects method (FEM: no by in vitro fertilization with autologous heterogeneity between the studies). oocytes (IVF). The weighted OR under a random effects model was 2.9 (95%CI 2.19 to Methods: A systematic review was performed 3.85). The meta-regression analysis to identify relevant studies published from showed that neither multiple January 1994 until April 2015 with at least an pregnancies (estimate = 0.08; p = 0.19) abstract in English using PubMed, ISI Web of nor patient age (estimate = -2.29; p = Knowledge, and clinicaltrials.gov. The studies 0.13) significantly explained the included in this systematic review were variability of the effect of oocyte retrospective and prospective cohort studies donation on PE. Q statistic was 12.78 (p of women reporting results on the association = 0.237), suggesting absence of between oocyte donation vs. in vitro heterogeneity between the studies. fertilization (exposure) and preeclampsia (outcome). Donor insemination I 7 studies Aim: to evaluate whether women who Conception using donor sperm was Included studies () conceive with donor sperm have an associated with an increased risk of were 10,898 increased risk of preeclampsia compared preeclampsia (OR 1.63, 95%CI 1.36 to observational women with those who use their partner's sperm. 1.95) compared with using a partner's sperm. No difference was observed in Methods: Studies that compared women the risk of gestational hypertension who were impregnated by donor (n=2,342) (OR 0.94, 95% CI 0.43-2.03). and partner (n=8,556) sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates.
() I 11 studies Aim: to determine whether there is a higher incidence of preeclampsia (PE) in pregnancies achieved by oocyte donation (OD) compared with pregnancies achieved by in vitro fertilization with autologous oocytes (IVF). Methods: A systematic review was performed to identify relevant studies published from January 1994 until April 2015 with at least an abstract in English using PubMed, ISI Web of Knowledge, and clinicaltrials.gov. The studies included in this systematic review were retrospective and prospective cohort studies of women reporting results on the association between oocyte donation vs. in vitro fertilization (exposure) and preeclampsia (outcome). Oocyte donation is a risk factor for the development of PE compared to IVF cycles, with a weighted OR of 3.12 under a fixed effects method (FEM: no heterogeneity between the studies). The weighted OR under a random effects model was 2.9 (95%CI 2.19 to 3.85). The meta-regression analysis showed that neither multiple pregnancies (estimate = 0.08; p = 0.19) nor patient age (estimate = -2.29; p = 0.13) significantly explained the variability of the effect of oocyte donation on PE. Q statistic was 12.78 (p = 0.237), suggesting absence of heterogeneity between the studies. Donor insemination () I 7 studies 10,898 women Aim: to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Methods: Studies that compared women who were impregnated by donor (n=2,342) and partner (n=8,556) sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Conception using donor sperm was associated with an increased risk of preeclampsia (OR 1.63, 95%CI 1.36 to 1.95) compared with using a partner's sperm. No difference was observed in the risk of gestational hypertension (OR 0.94, 95% CI 0.43-2.03). Included studies were observational
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