Pharmacotherapy Depressive symptoms – Amodeo RCT Italian cancer 50% with Intervention: Intervention: 2.5 Hospital N = 30 et al. patients with adjustment titration of m/g day increasing Anxiety and (2011) depressive disorder with paroxetine (SSRI) by 2.5m/g each third Depression disorders depressed Control: day until 10m/g was Scale mood titration of reached day 8. Day 9 (HADS) Intervention: paroxetine (SSRI) dose was increased Montgomery Age: 59.9 to 15m/g day and on Asberg (11.7) Stressor: day 11 the full 20m/g Depression Male: 27% Health day dose was Rating Scale reached (MADRS) Control: Control: 10m/g day Hamilton Age: 61.8 and increased to Anxiety (10.5) 20m/g day on day 8 Rating Scale Male: 33% (HAM-A) Both treatments Clinical lasted 8 weeks Global Impression (CGI)
Pharmacotherapy – Depressive symptoms Amodeo et al. (2011) RCT Italian cancer patients with depressive disorders Intervention: Age: 59.9 (11.7) Male: 27% Control: Age: 61.8 (10.5) Male: 33% 50% with adjustment disorder with depressed mood Stressor: Health Intervention: titration of paroxetine (SSRI) Control: titration of paroxetine (SSRI) Intervention: 2.5 m/g day increasing by 2.5m/g each third day until 10m/g was reached day 8. Day 9 dose was increased to 15m/g day and on day 11 the full 20m/g day dose was reached Control: 10m/g day and increased to 20m/g day on day 8 Both treatments lasted 8 weeks Hospital Anxiety and Depression Scale (HADS) Montgomery Asberg Depression Rating Scale (MADRS) Hamilton Anxiety Rating Scale (HAM-A) Clinical Global Impression (CGI) N = 30
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