A.1.3 Acute toxicity oral – Test Substance ABIL Quat 3474 Method Similar to OECD TG 401 Acute Oral Toxicity Limited Test – Species/Strain Rat/Sprague Dawley (albino) Vehicle None Remarks Method No significant protocol deviations – Results Group Number and sex of Dose (mg/kg bw) Mortality animals 1 5 males, 5 females 5000 0 LD50 >5000 mg/kg bw Remarks Signs of None – toxicity Conclusion ABIL Quat 3272 is of low toxicity via the oral route Test Facility Product Safety Labs (1995a) A.1.4 Irritation skin – Test Substance ABIL Quat 3270 Method Primary Dermal Irritation Test US Federal Guidelines 16 CFR 1500.41 PSL Protocol 002/P201 Species/Strain Rabbit/New Zealand White (albino) Number of animals 6 males Vehicle Distilled water Observation period 3 days Type of dressing Semi-occlusive Remarks Method Abraded skin and intact skin sites on each animal were tested – with the test substance as a 10% w/w solution for a 24 hour exposure period. Observations were recorded at 24 and 72 hours after patch removal only. The FHSA Primary Skin Irritation Scoring system was used to grade the skin reaction observations. Original data tables were not provided. Results Remarks Results At 24 hour post-dosing, moderate to well-defined erythema – was observed at all abraded and intact sites. Oedema ranging from very slight to slight was observed at all but one abraded site and at all intact sites. By 72 hours, erythema in four rabbits increased from well-defined to severe. Thickening of the skin was noted at all sites. The remaining two rabbits had eschar at the abraded site, with erythema being stable at the intact sites. Oedema cleared in one rabbit and remained stable
A.1.3 Acute toxicity – oral Test Substance ABIL Quat 3474 Method Similar to OECD TG 401 Acute Oral Toxicity – Limited Test Species/Strain Rat/Sprague Dawley (albino) Vehicle None Remarks – Method No significant protocol deviations Results Group Number and sex of animals Dose (mg/kg bw) Mortality 1 5 males, 5 females 5000 0 LD50 >5000 mg/kg bw Remarks – Signs of toxicity None Conclusion ABIL Quat 3272 is of low toxicity via the oral route Test Facility Product Safety Labs (1995a) A.1.4 Irritation – skin Test Substance ABIL Quat 3270 Method Primary Dermal Irritation Test US Federal Guidelines 16 CFR 1500.41 PSL Protocol 002/P201 Species/Strain Rabbit/New Zealand White (albino) Number of animals 6 males Vehicle Distilled water Observation period 3 days Type of dressing Semi-occlusive Remarks – Method Abraded skin and intact skin sites on each animal were tested with the test substance as a 10% w/w solution for a 24 hour exposure period. Observations were recorded at 24 and 72 hours after patch removal only. The FHSA Primary Skin Irritation Scoring system was used to grade the skin reaction observations. Original data tables were not provided. Results Remarks – Results At 24 hour post-dosing, moderate to well-defined erythema was observed at all abraded and intact sites. Oedema ranging from very slight to slight was observed at all but one abraded site and at all intact sites. By 72 hours, erythema in four rabbits increased from well-defined to severe. Thickening of the skin was noted at all sites. The remaining two rabbits had eschar at the abraded site, with erythema being stable at the intact sites. Oedema cleared in one rabbit and remained stable
Polysiloxanes-di-Me-NA103S_Final-SN-Report.docx