Cohort III-2 150 Aim: to analyze whether estimation of Mean serum PlGF levels were found () serum PlGF levels in late second to be significantly low in mild and trimester can act as a predictor of severe pre-eclampsia as compared preeclampsia. to normal pregnancy. Serum PlGF levels were highest at 26–28 weeks Methods Nulliparous women were and were lowered at 28–30 and 30–32 divided into three groups: normotensive weeks of gestation within each of the (n=30), mild (n=60) and severe (n=60) three study groups. Cut-off value of preeclampsia. Serum samples serum PlGF levels for predicting collected from the study groups were and severe pre-eclampsia subjected to ELISA, and serum PlGF were <20 and <107 pg/mL, level was calculated. respectively. Cohort III-2 722 Aim: To determine whether maternal Maternal serum PlGF level <155 () serum PlGF estimation in early second pg/mL at 20-22 weeks of gestation trimester (20-22 weeks) can predict the had a strong association with early occurrence of early onset onset preeclampsia (OR 8.35; 95%CI preeclampsia and/or early onset (<32 1.79 to 18.94; P=0.007). The sensitivity wks) IUGR. of serum PlGF <155 pg/mL for predicting early onset preeclampsia Methods: Singleton pregnancies were was 82. screened and serum PlGF levels were estimated at 20-22 weeks of gestation. A cut-off value of <155 pg/mL for serum PlGF was determined by ROC analysis. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures OR was computed.
() Cohort III-2 150 Aim: to analyze whether estimation of serum PlGF levels in late second trimester can act as a predictor of preeclampsia. Methods Nulliparous women were divided into three groups: normotensive (n=30), mild (n=60) and severe (n=60) preeclampsia. Serum samples collected from the study groups were subjected to ELISA, and serum PlGF level was calculated. Mean serum PlGF levels were found to be significantly low in mild and severe pre-eclampsia as compared to normal pregnancy. Serum PlGF levels were highest at 26–28 weeks and were lowered at 28–30 and 30–32 weeks of gestation within each of the three study groups. Cut-off value of serum PlGF levels for predicting and severe pre-eclampsia were <20 and <107 pg/mL, respectively. () Cohort III-2 722 Aim: To determine whether maternal serum PlGF estimation in early second trimester (20-22 weeks) can predict the occurrence of early onset preeclampsia and/or early onset (<32 wks) IUGR. Methods: Singleton pregnancies were screened and serum PlGF levels were estimated at 20-22 weeks of gestation. A cut-off value of <155 pg/mL for serum PlGF was determined by ROC analysis. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures OR was computed. Maternal serum PlGF level <155 pg/mL at 20-22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95%CI 1.79 to 18.94; P=0.007). The sensitivity of serum PlGF <155 pg/mL for predicting early onset preeclampsia was 82.
Preeclampsia%20evaluation%20report%2016May17.docx