Assisted reproductive technology Study ref LoE N Aim/ methods Findings Comments Oocyte donation I 19 studies Aim: to determine whether pregnancies that Our pooled data demonstrated that () were achieved via oocyte donation, the risk of preeclampsia is higher in 86,515 compared with pregnancies achieved via oocyte-donation pregnancies pregnancies other assisted reproductive technology compared with other methods of methods or natural conception, demonstrate assisted reproductive technology (OR increased risk of preeclampsia or gestational 2.54; 95%CI 1.98 to 3.24; P<0.0001) or hypertension. natural conception (OR 4.34; 95%CI 3.10 to 6.06; P <.0001). Subgroup analysis Methods: Comparative studies of conducted for singleton and multiple pregnancies that were achieved with oocyte gestations demonstrated a similar risk for donation vs other methods of assisted preeclampsia and gestational reproductive technology or natural hypertension in both singleton and conception with preeclampsia or gestational multiple gestations. hypertension were included as 1 of the measured outcomes. Two reviewers independently selected studies, which were assessed for quality with the use of methodological index for non-randomized studies, and extracted the data. Statistical analysis was conducted.
Assisted reproductive technology Study ref LoE N Aim/ methods Findings Comments Oocyte donation () I 19 studies 86,515 pregnancies Aim: to determine whether pregnancies that were achieved via oocyte donation, compared with pregnancies achieved via other assisted reproductive technology methods or natural conception, demonstrate increased risk of preeclampsia or gestational hypertension. Methods: Comparative studies of pregnancies that were achieved with oocyte donation vs other methods of assisted reproductive technology or natural conception with preeclampsia or gestational hypertension were included as 1 of the measured outcomes. Two reviewers independently selected studies, which were assessed for quality with the use of methodological index for non-randomized studies, and extracted the data. Statistical analysis was conducted. Our pooled data demonstrated that the risk of preeclampsia is higher in oocyte-donation pregnancies compared with other methods of assisted reproductive technology (OR 2.54; 95%CI 1.98 to 3.24; P<0.0001) or natural conception (OR 4.34; 95%CI 3.10 to 6.06; P <.0001). Subgroup analysis conducted for singleton and multiple gestations demonstrated a similar risk for preeclampsia and gestational hypertension in both singleton and multiple gestations.
Preeclampsia%20evaluation%20report%2016May17.docx