14 Male Cough symptom score (0-100 VAS) Matthys Germany Chronic stable 55.9 (17.2) 16 2 doses of codeine Placebo Cough 8 h 1983 cough due to M: 11 phosphate 20 mg for frequency (per pulmonary F: 5 three consecutive hour) tuberculosis, nights bronchial carcinoma or obstructive lung disease Eccles 1992 Wales, Cardiff Cough associated 23 91 Codeine 30 mg / 10 Placebo Cough ~ 3 h with acute upper M: 47 mL four times a day frequency per (150 minutes) respiratory tract F: 44 up to 120 mg codeine minute infection / day Cough severity (0-100 VAS) Freestone Cardiff, Cough associated 23.5 82 Single dose of Placebo Cough 90 minutes 1997 UK with upper F: 51 codeine 50 mg frequency respiratory tract M: 31 capsules infection I: Intervention; P: Placebo
14 Male Cough symptom score (0-100 VAS) Matthys 1983 Germany Chronic stable cough due to pulmonary tuberculosis, bronchial carcinoma or obstructive lung disease 55.9 (17.2) 16 M: 11 F: 5 2 doses of codeine phosphate 20 mg for three consecutive nights Placebo Cough frequency (per hour) 8 h Eccles 1992 Wales, Cardiff Cough associated with acute upper respiratory tract infection 23 91 M: 47 F: 44 Codeine 30 mg / 10 mL four times a day up to 120 mg codeine / day Placebo Cough frequency per minute Cough severity (0-100 VAS) ~ 3 h (150 minutes) Freestone 1997 Cardiff, UK Cough associated with upper respiratory tract infection 23.5 82 F: 51 M: 31 Single dose of codeine 50 mg capsules Placebo Cough frequency 90 minutes I: Intervention; P: Placebo
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