High titre low-avidity antibodies Unlikely Local policy or seek (HTLA) advice from reference laboratory Antibodies to low/high frequency Depends on policy or seek antigens specificity advice from reference laboratory policy or seek Other antibodies active by IAT at 37°C advice from reference laboratory * Antigen negative red cells should be crossmatched by IAT at 37°C For rare anti sera IAT, crossmatch compatible blood is appropriate if antisera is not available Appendix B Red Cell Antibodies and the Risk of HDFN (Informative)8 HDFN HDFN Severity Antibody Specificity Likelihood Rh Common Mild to severe Kell Common Mild to severe
High titre low-avidity antibodies (HTLA) Unlikely Local policy or seek advice from reference laboratory Antibodies to low/high frequency antigens Depends on specificity policy or seek advice from reference laboratory Other antibodies active by IAT at 37°C policy or seek advice from reference laboratory * Antigen negative red cells should be crossmatched by IAT at 37°C For rare anti sera IAT, crossmatch compatible blood is appropriate if antisera is not available Appendix B Red Cell Antibodies and the Risk of HDFN (Informative)8 Antibody Specificity HDFN Likelihood HDFN Severity Rh Common Mild to severe Kell Common Mild to severe
Reqs%20Transfusion%20Lab%20Pract%20-3rd%20Ed%20.docx