Male: 33% Both treatments lasted Clinical Global 8 weeks Impression (CGI) Quality of life (EORTC QLQ-C30) Both groups reduced significantly in their MADRS, HADS, HAM-A scores, and CGI scores in addition to improving their quality of life scores from to end of treatment. Those who received slow-up titration paroxetine had significantly lower MADRS scores at mid-treatment (4 weeks) and significant lower HADS scores at mid treatment (4 weeks) and end of treatment (8 weeks). There was no significant differences between groups on HAM-A scores or quality of life total scores at the end of treatment. There was no significant differences in CGI improvement between groups. Participants in the intervention arm (slow-up titration paroxetine) reported less side effects than the controls. Hameed et Primary care 34% adjustment Pharmacotherapy (24% of patients Naturalistic delivery - Number of N = 96 al. (2005) cohort patients with disorder with received concurrent of antidepressant DSM-IV followed depressive depressed psychotherapy) medication as symptoms over 4 disorders mood (DSM-IV) determined by the - Patient Health months receiving depression Questionnaire Stressor: Not management team (PHQ-9) Age: Unknown reported Male: 20%
Male: 33% Both treatments lasted 8 weeks Clinical Global Impression (CGI) Quality of life (EORTC QLQ-C30) Both groups reduced significantly in their MADRS, HADS, HAM-A scores, and CGI scores in addition to improving their quality of life scores from to end of treatment. Those who received slow-up titration paroxetine had significantly lower MADRS scores at mid-treatment (4 weeks) and significant lower HADS scores at mid treatment (4 weeks) and end of treatment (8 weeks). There was no significant differences between groups on HAM-A scores or quality of life total scores at the end of treatment. There was no significant differences in CGI improvement between groups. Participants in the intervention arm (slow-up titration paroxetine) reported less side effects than the controls. Hameed et al. (2005) cohort followed over 4 months Primary care patients with depressive disorders receiving Age: Unknown Male: 20% 34% adjustment disorder with depressed mood (DSM-IV) Stressor: Not reported Pharmacotherapy (24% of patients received concurrent psychotherapy) Naturalistic delivery of antidepressant medication as determined by the depression management team - Number of DSM-IV symptoms - Patient Health Questionnaire (PHQ-9) N = 96
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