Cohort III-2 176 Aim: To evaluate the NICE and The NICE guideline had a higher () PRECOG guidelines risk factors for sensitivity rate of 77% (95%CI 65 to to identify mothers at risk 87%) vs 59% (95% CI 46 to 71%) but a before 20 weeks' gestation. Cases lower specificity of 54% (95% CI 44 to (n=64) and controls (n=112) were 64%) vs 81% (95% CI 73 to 88%) with classified retrospectively as screen the PRECOG guideline. Based on an positive or negative as recommended incidence of pre-eclampsia of 4% the by the two guidelines PPVs of PRECOG and NICE guidelines were estimated at only 11% and 7%, respectively. The most discriminatory risk factor was history of pre-eclampsia in a previous pregnancy. Cohort III-2 615 Aim: To determine the diagnostic The multivariate screening effectively () accuracy of preeclampsia (PE) identified cases of PE with >97% screening test offered in early specificity. The detection rate (DR) pregnancy for the prediction of the risks was 93.8% for late-onset PE at a false for early-onset (requiring delivery <32 positive rate (FPR) of 2.3% and 44.4% weeks gestation) and late onset for early-onset PE at an FPR of 0.0%. (requiring delivery ≥32 weeks gestation) The incidence of PE was 7% overall, disease. with 1.52% and 5.43% for early- and late-onset PE, respectively. The study Methods: In women with singleton demonstrated 96.6% diagnostic pregnancy, the risk for PE was accuracy of the multi-variable calculated by the combined effect of screening test to predict the risk of PE multiple variables: serum PlGF, PAPP-A, in the first trimester. The negative maternal age, parity, ethnicity, MAP, predictive value (>98%) reinforces the BMI, UtA PI, and previous history of PE or utility of cost-effective noninvasive hypertension (HT). The results of the screening test for the early detection screening test in three different groups of PE. of women were validated by pregnancy outcome: control group; history of PE without HT; and (iii) history of HT without PE.
() Cohort III-2 176 Aim: To evaluate the NICE and PRECOG guidelines risk factors for to identify mothers at risk before 20 weeks' gestation. Cases (n=64) and controls (n=112) were classified retrospectively as screen positive or negative as recommended by the two guidelines The NICE guideline had a higher sensitivity rate of 77% (95%CI 65 to 87%) vs 59% (95% CI 46 to 71%) but a lower specificity of 54% (95% CI 44 to 64%) vs 81% (95% CI 73 to 88%) with the PRECOG guideline. Based on an incidence of pre-eclampsia of 4% the PPVs of PRECOG and NICE guidelines were estimated at only 11% and 7%, respectively. The most discriminatory risk factor was history of pre-eclampsia in a previous pregnancy. () Cohort III-2 615 Aim: To determine the diagnostic accuracy of preeclampsia (PE) screening test offered in early pregnancy for the prediction of the risks for early-onset (requiring delivery <32 weeks gestation) and late onset (requiring delivery ≥32 weeks gestation) disease. Methods: In women with singleton pregnancy, the risk for PE was calculated by the combined effect of multiple variables: serum PlGF, PAPP-A, maternal age, parity, ethnicity, MAP, BMI, UtA PI, and previous history of PE or hypertension (HT). The results of the screening test in three different groups of women were validated by pregnancy outcome: control group; history of PE without HT; and (iii) history of HT without PE. The multivariate screening effectively identified cases of PE with >97% specificity. The detection rate (DR) was 93.8% for late-onset PE at a false positive rate (FPR) of 2.3% and 44.4% for early-onset PE at an FPR of 0.0%. The incidence of PE was 7% overall, with 1.52% and 5.43% for early- and late-onset PE, respectively. The study demonstrated 96.6% diagnostic accuracy of the multi-variable screening test to predict the risk of PE in the first trimester. The negative predictive value (>98%) reinforces the utility of cost-effective noninvasive screening test for the early detection of PE.
Preeclampsia%20evaluation%20report%2016May17.docx