metabolite 1-methyl-3-(tetrahydro-3-furylmethyl)urea (UF) was found to be a significant component in whole rice (5.6–17.2 % TRR) and rice straw (8.1–15.9% TRR). For rotational crops, one application of 14C-dinotefuran was made to bare soil at 608 g ai/ha. Following a 30 or 120 day Plant Back Interval (PBI), radishes, lettuces and cereals (sorghum or wheat) were planted. Total radioactive residue levels above 0.010 mg eq/kg plant part were detected in the plants originating from the 30–day field plot. However, the total radioactive residue was below 0.010 mg eq/ kg for all plant parts originating from the plants grown in the 120–day field plot, except for the radish leaf which had residues of 0.035 ppm and 0.026 mg eq/kg for immature and mature leaf samples, respectively. Analyses of the samples of the 120–day field plot showed that no radioactive component exceeded 0.006 mg eq/kg (DN). Parent dinotefuran and its MNG, UF, BCDN and DN metabolites were significant components in rotational crops. The proposed metabolic pathway for dinotefuran in plants is presented below. Figure 2: The Proposed metabolic pathway for dinotefuran in plants Animals For lactating goats, 14C-dinotefuran was orally administered daily for 5 consecutive days at an actual dose of 8.8 ppm in the feed. TRR levels in goat milk, muscle, fat, liver and kidney were low (0.012–0.272 mg eq/kg), with the majority of the TRR being detected in urine and faeces (7.15 and 3.02 mg eq/kg respectively
metabolite 1-methyl-3-(tetrahydro-3-furylmethyl)urea (UF) was found to be a significant component in whole rice (5.6–17.2 % TRR) and rice straw (8.1–15.9% TRR). For rotational crops, one application of 14C-dinotefuran was made to bare soil at 608 g ai/ha. Following a 30 or 120 day Plant Back Interval (PBI), radishes, lettuces and cereals (sorghum or wheat) were planted. Total radioactive residue levels above 0.010 mg eq/kg plant part were detected in the plants originating from the 30–day field plot. However, the total radioactive residue was below 0.010 mg eq/ kg for all plant parts originating from the plants grown in the 120–day field plot, except for the radish leaf which had residues of 0.035 ppm and 0.026 mg eq/kg for immature and mature leaf samples, respectively. Analyses of the samples of the 120–day field plot showed that no radioactive component exceeded 0.006 mg eq/kg (DN). Parent dinotefuran and its MNG, UF, BCDN and DN metabolites were significant components in rotational crops. The proposed metabolic pathway for dinotefuran in plants is presented below. Figure 2: The Proposed metabolic pathway for dinotefuran in plants Animals For lactating goats, 14C-dinotefuran was orally administered daily for 5 consecutive days at an actual dose of 8.8 ppm in the feed. TRR levels in goat milk, muscle, fat, liver and kidney were low (0.012–0.272 mg eq/kg), with the majority of the TRR being detected in urine and faeces (7.15 and 3.02 mg eq/kg respectively
18426-18426-prs-dinotefuran.docx