3. The number and rate of suicides involving single-drugs or single and multiple (first-listed) drugs in England and the number and rates of non-fatal self-poisoning episodes in three centres in England, in individuals aged 15 years and over Fatal self-poisoning in England (2005-12) Non-fatal self-poisoning Single drug Single drug and first in the 3 centres (2005-12) listed drug Total Death rate per Total Death rate per Average Prescription N 100,000 N 100,000 Number rate per person-years per year 100,000 (95% CI) (95% CI) (95% CI) Diazepam 12 0.0035 35 0.0102 250 34.92 (0.0018-0.0061) (0.0071-0.0142) (33.41-36.48) Temazepam 58 0.0170 81 0.0236 93 12.94 (0.0129-0.0219) (0.0188-0.0294) (12.03-13.91) Chlordiazepoxide 4 0.0012 4 0.0012 26 3.56 (0.0003-0.0030) (0.0003-0.0030) (3.09-4.08) Lorazepam 2 0.0006 5 0.0015 30 4.19 (0.0005-0.0034) (3.67-4.75) Nitrazepam 7 0.0021 9 0.0026 23 3.24
3. The number and rate of suicides involving single-drugs or single and multiple (first-listed) drugs in England and the number and rates of non-fatal self-poisoning episodes in three centres in England, in individuals aged 15 years and over Fatal self-poisoning in England (2005-12) Non-fatal self-poisoning in the 3 centres (2005-12) Single drug Single drug and first listed drug Total N Death rate per 100,000 (95% CI) Total N Death rate per 100,000 person-years (95% CI) Average Number per year Prescription rate per 100,000 (95% CI) Diazepam 12 0.0035 (0.0018-0.0061) 35 0.0102 (0.0071-0.0142) 250 34.92 (33.41-36.48) Temazepam 58 0.0170 (0.0129-0.0219) 81 0.0236 (0.0188-0.0294) 93 12.94 (12.03-13.91) Chlordiazepoxide 4 0.0012 (0.0003-0.0030) 4 0.0012 (0.0003-0.0030) 26 3.56 (3.09-4.08) Lorazepam 2 0.0006 5 0.0015 (0.0005-0.0034) 30 4.19 (3.67-4.75) Nitrazepam 7 0.0021 9 0.0026 23 3.24
Relative_toxicity_of_benzodiazepines_accepted_version.docx