Appendix Table 2: Data Extraction Table Treatment N Placebo N Mean Difference Clinically Significant Mean (SD) Mean (SD) Heidrich 1985 post – orthopaedic surgery Paracetamol 300 mg + codeine 30 mg VAS 0-100 3 h 54 (22.2) 40 65 (22.2) 40 -11.0 (-20.7, -1.3) Yes 6 h 71 (22.2) 40 68 (22.2) 40 3.0 (-6.7, 12.7) No Median SD value used Ahlstrom 1985 Paracetamol 1000 mg 15 (22.2) 44 46 (22.2) 85 -31.0 (-39.1, -22.9) YES + codeine 60 mg (treatment A) PID 12h Paracetamol 500 mg + 30 (22.2) 43 46 (22.2) 85 -16.0 (-24.1, -7.9) YES codeine 30 mg (treatment B) PID 12h Median SD used Giles 1986 (Median SD used) Ibuprofen 200 mg + codeine 15 mg 0-9 pain rating 3h 2.2 36 3.5 5h 2.4 36 2.5 35 0-100 3h 27.5 (22.2) 36 43.8 (22.2) 35 -16.3 (-26.6, -6.0) Yes 5h 30 (22.2) 36 2.5 (22.2) 35 -1.3 (-11.6, 9.0) No Skoglund 1991 Codeine 60 mg paracetamol 1000 mg PI VAS 0-100 3h 21 (22.2) 37 47 (22.2) 33 -26.0 (-36.4, -15.6) Yes 6h 27 (22.2) 37 42 (22.2) 33 -15.0 (-25.4, -4.6) Yes Median SD value used
Appendix Table 2: Data Extraction Table Treatment Mean (SD) N Placebo Mean (SD) N Mean Difference Clinically Significant Heidrich 1985 – post orthopaedic surgery Paracetamol 300 mg + codeine 30 mg VAS 0-100 3 h 6 h Median SD value used 54 (22.2) 71 (22.2) 40 40 65 (22.2) 68 (22.2) 40 40 -11.0 (-20.7, -1.3) 3.0 (-6.7, 12.7) Yes No Ahlstrom 1985 Paracetamol 1000 mg + codeine 60 mg (treatment A) PID 12h Paracetamol 500 mg + codeine 30 mg (treatment B) PID 12h Median SD used 15 (22.2) 30 (22.2) 44 43 46 (22.2) 46 (22.2) 85 85 -31.0 (-39.1, -22.9) -16.0 (-24.1, -7.9) YES YES Giles 1986 (Median SD used) Ibuprofen 200 mg + codeine 15 mg 0-9 pain rating 3h 5h 0-100 3h 5h 2.2 2.4 27.5 (22.2) 30 (22.2) 36 36 36 36 3.5 2.5 43.8 (22.2) 2.5 (22.2) 35 35 35 -16.3 (-26.6, -6.0) -1.3 (-11.6, 9.0) Yes No Skoglund 1991 Codeine 60 mg paracetamol 1000 mg PI VAS 0-100 3h 6h Median SD value used 21 (22.2) 27 (22.2) 37 37 47 (22.2) 42 (22.2) 33 33 -26.0 (-36.4, -15.6) -15.0 (-25.4, -4.6) Yes Yes
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