Region Characteristic Value Glomeruli Mean number examined 15.3 ± 7.8 Normal or minimal lesions 13 (22.8) Segmental sclerosis 40 (70.2) Mesangium Hypercellularity 17 (29.8) Increased matrix 22 (38.6) Tubules and interstitium Interstitial fibrosis or tubular 42 (73.4) atrophy Immunofluorescence / Any other immunoglobulin 4 (7.0) Immunoperoxidase C3 29 (50.9) C1q 30 (52.6) Electron microscopy (EM) Segmental epithelial foot 22 (38.6) process effacement Mesangial expansion 40 (70.2) Table : Clinical and histological features of those undergoing a repeated renal biopsy Time Patient IgM Mesangial Rebiopsy Sex Age to re- Indication Treatment No stain EDD finding biopsy 1 F 41 4.5 Cr up 1+ N/A Prednisolone FSGS 2 F 33 4.1 Cr up 1+ N None FSGS 3 M 20 2.0 Nephrotic 1+ Y None IgMN
Region Characteristic Value Glomeruli Mean number examined 15.3 ± 7.8 Normal or minimal lesions 13 (22.8) Segmental sclerosis 40 (70.2) Mesangium Hypercellularity 17 (29.8) Increased matrix 22 (38.6) Tubules and interstitium Interstitial fibrosis or tubular atrophy 42 (73.4) Immunofluorescence / Immunoperoxidase Any other immunoglobulin 4 (7.0) C3 29 (50.9) C1q 30 (52.6) Electron microscopy (EM) Segmental epithelial foot process effacement 22 (38.6) Mesangial expansion 40 (70.2) Table : Clinical and histological features of those undergoing a repeated renal biopsy Patient No Sex Age Time to re- biopsy Indication IgM stain Mesangial EDD Treatment Rebiopsy finding 1 F 41 4.5 Cr up 1+ N/A Prednisolone FSGS 2 F 33 4.1 Cr up 1+ N None FSGS 3 M 20 2.0 Nephrotic 1+ Y None IgMN
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