SPs who weigh more than 100 pounds will drink 10 ounces of Trutol®. SPs who weigh less than 94 pounds must have a calibrated dose of Trutol®. Note: The investigator should record the calibrated amount of Trutol® given to the sample person. Ask the SP to indicate a preference for one of the three flavors. Choose the flavor that matches the preference of the soft drink flavor that he or she prefers. Follow the instructions; remove the correct amount of Trutol® from the bottle before handing the bottle to the SP. Use a small medicine cup to measure the correct amount to remove and discard the excess Trutol®. Hand the SP a cold bottle of Trutol® (containing the calibrated dose) and a straw. SPs MUST consume the entire calibrated dose of the Trutol within 10 minutes. Recite the script "Please drink this solution within 10 minutes" and start the timer. The timer counts down from 10:00 minutes. When the SP has finished drinking the entire calibrated dose of Trutol®, or cannot continue drinking the Trutol, then stop the timer. The choices for the amount of solution that the SP consumed are "All," "Some," or "None." Record the amount of solution the SP drank. If the SP drank "some" or "none" of the Trutol® solution, then the section status is Not Done. If the total time is 00:10:00, then "Solution not consumed in 10 minutes." Second Venipuncture If an SP consumed the entire calibrated dose of the Trutol® solution in 10 minutes, then he or she is eligible to have a 2-ml gray top tube drawn 2
SPs who weigh more than 100 pounds will drink 10 ounces of Trutol®. SPs who weigh less than 94 pounds must have a calibrated dose of Trutol®. Note: The investigator should record the calibrated amount of Trutol® given to the sample person. Ask the SP to indicate a preference for one of the three flavors. Choose the flavor that matches the preference of the soft drink flavor that he or she prefers. Follow the instructions; remove the correct amount of Trutol® from the bottle before handing the bottle to the SP. Use a small medicine cup to measure the correct amount to remove and discard the excess Trutol®. Hand the SP a cold bottle of Trutol® (containing the calibrated dose) and a straw. SPs MUST consume the entire calibrated dose of the Trutol within 10 minutes. Recite the script "Please drink this solution within 10 minutes" and start the timer. The timer counts down from 10:00 minutes. When the SP has finished drinking the entire calibrated dose of Trutol®, or cannot continue drinking the Trutol, then stop the timer. The choices for the amount of solution that the SP consumed are "All," "Some," or "None." Record the amount of solution the SP drank. If the SP drank "some" or "none" of the Trutol® solution, then the section status is Not Done. If the total time is 00:10:00, then "Solution not consumed in 10 minutes." Second Venipuncture If an SP consumed the entire calibrated dose of the Trutol® solution in 10 minutes, then he or she is eligible to have a 2-ml gray top tube drawn 2
141001_Protocol.docx