Defects in T-cell-mediated immunity viruses, fungi, and intracellular bacteria result in recurrent infections with what type of intracellular pathogens? What system is part of the innate, The phagocytic system antigen-nonspecific immune response and includes neutrophils and mononuclear phagocytic What system is activated to produce The complement system biologically active molecules that enhance inflammation and promote lysis of cells and microorganisms. What are the mechanisms of the Genetic defects in B-cell maturation or mutations agammaglobulinemias? leading to defective interactions between B and T cells. In evaluating immunoglobulin blood levels of immunoglobulins deficiency states, it is important to remember this varies with age When does IgM reach normal adult 1st year of age levels? When does IgG reach normal adult 5-6 of age levels? True or False: In some normal True. children, IgA levels do not reach normal adult values until adolescence. All infants experience low levels of 5-6 months immunoglobulins at approximately ____ of age, but in some cases, the low levels persist for a longer time. Transient hypogammaglobulinemia Low levels of immunoglobulins past 5-6 months of of infancy (THI) may result due to age what? What is the mechanism of transient Unknown hypogammaglobulinemia? In THI, what type of immunity is Cell-mediated immunity normal? In THI, what Ig is the most affected, IgG dropping at 2 SDs below the age-adjusted mean? THI patients have normal numbers of Bruton’s agammaglobulinemia circulating CD19 positive unlike what agammaglobulinemia? First described in 1952, this Bruton’s agammaglobulinemia agammaglobulinemia is X chromosome–linked, and so affects males almost exclusively.
Defects in T-cell-mediated immunity result in recurrent infections with what type of intracellular pathogens? viruses, fungi, and intracellular bacteria What system is part of the innate, antigen-nonspecific immune response and includes neutrophils and mononuclear phagocytic The phagocytic system What system is activated to produce biologically active molecules that enhance inflammation and promote lysis of cells and microorganisms. The complement system What are the mechanisms of the agammaglobulinemias? Genetic defects in B-cell maturation or mutations leading to defective interactions between B and T cells. In evaluating immunoglobulin deficiency states, it is important to remember this varies with age blood levels of immunoglobulins When does IgM reach normal adult levels? 1st year of age When does IgG reach normal adult levels? 5-6 of age True or False: In some normal children, IgA levels do not reach normal adult values until adolescence. True. All infants experience low levels of immunoglobulins at approximately ____ of age, but in some cases, the low levels persist for a longer time. 5-6 months Transient hypogammaglobulinemia of infancy (THI) may result due to what? Low levels of immunoglobulins past 5-6 months of age What is the mechanism of transient hypogammaglobulinemia? Unknown In THI, what type of immunity is normal? Cell-mediated immunity In THI, what Ig is the most affected, dropping at 2 SDs below the age-adjusted mean? IgG THI patients have normal numbers of circulating CD19 positive unlike what agammaglobulinemia? Bruton’s agammaglobulinemia First described in 1952, this agammaglobulinemia is X chromosome–linked, and so affects males almost exclusively. Bruton’s agammaglobulinemia
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