, gels or of heterogeneity prevented fraction varnishes) between studies has estimate was 26% been important in the (95% CI, 24% to Children and overall conclusions 29%; P < 0.0001). adolescents. reached, these should There was be interpreted with substantial caution. We were heterogeneity, unable to reach confirmed definite conclusions statistically (P < about any adverse 0.0001), but the effects that might direction of effect result from the use of was consistent. topical fluorides, The effect of topical because data reported fluoride varied in the trials are scarce according to type of control group used, type of TFT used, mode/setting of TFT use, initial caries levels and intensity of TFT application, but was not influenced by exposure to water
gels or varnishes) Children and adolescents. of heterogeneity between studies has been important in the overall conclusions reached, these should be interpreted with caution. We were unable to reach definite conclusions about any adverse effects that might result from the use of topical fluorides, because data reported in the trials are scarce prevented fraction estimate was 26% (95% CI, 24% to 29%; P < 0.0001). There was substantial heterogeneity, confirmed statistically (P < 0.0001), but the direction of effect was consistent. The effect of topical fluoride varied according to type of control group used, type of TFT used, mode/setting of TFT use, initial caries levels and intensity of TFT application, but was not influenced by exposure to water ,
Initiative%20assessment%20report%20D2S%20final.docx