addition to fluoride data for the of topical toothpaste achieve a modest reduction in 9 trials for the main fluoride caries compared to meta-analysis on toothpaste used alone. the effect of fluoride No conclusions about mouthrinses, gels or gels, any adverse effects varnishes used in varnishes) could be reached, combination with versus because data were toothpaste single scarcely reported in (involving 4026 topical the trials. children) the fluoride D(M)FS pooled PF was 10% (95% CI, Children and 2% to 17%; P = Adolescents 0.01) in favour of the combined regimens. Heterogeneity was not substantial in these results (I2 = 32%). The separate of fluoride gel or mouthrinse
of topical fluoride gels, varnishes) versus single topical fluoride Children and Adolescents addition to fluoride toothpaste achieve a modest reduction in caries compared to toothpaste used alone. No conclusions about any adverse effects could be reached, because data were scarcely reported in the trials. data for the 9 trials for the main meta-analysis on the effect of fluoride mouthrinses, gels or varnishes used in combination with toothpaste (involving 4026 children) the D(M)FS pooled PF was 10% (95% CI, 2% to 17%; P = 0.01) in favour of the combined regimens. Heterogeneity was not substantial in these results (I2 = 32%). The separate of fluoride gel or mouthrinse
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