3. Findings of the assessment 1: Evidence Mapping Table for Designed to Smile Study Study design Outcome Main findings Results Evidence Include? Details measures Grading Reason for exclusion Marinho, Systematic The main Supported by more 74 studies were ++ Exclude VCC et al, Review and outcome than half a century of included, 70 that 2009 Meta-analysis was caries research, the benefits contributed data for Provides increment of fluoride toothpastes meta-analysis evidence Fluoride measured are firmly established. (involving 42,300 for use of toothpastes by the Trial together, the children) the fluoride for change in trials are of relatively D(M)FS pooled PF toothpaste, preventing decayed, high quality, and was 24% (95% limited dental caries missing provide clear evidence confidence interval information and filled that fluoride (CI), 21 to 28%; P on Children and tooth toothpastes are < 0.0001). supervised Adolescents surfaces efficacious in In populations with brushing as (D(M)FS). preventing caries caries increment of in 2.6 D(M)FS per year, 1.6 children need to brush with a fluoride toothpaste (rather than a toothpaste) to prevent one D(M)FS.
3. Findings of the assessment 1: Evidence Mapping Table for Designed to Smile Study Details Study design Outcome measures Main findings Results Evidence Grading Include? Reason for exclusion Marinho, VCC et al, 2009 Fluoride toothpastes for preventing dental caries Children and Adolescents Systematic Review and Meta-analysis The main outcome was caries increment measured by the change in decayed, missing and filled tooth surfaces (D(M)FS). Supported by more than half a century of research, the benefits of fluoride toothpastes are firmly established. together, the trials are of relatively high quality, and provide clear evidence that fluoride toothpastes are efficacious in preventing caries 74 studies were included, 70 that contributed data for meta-analysis (involving 42,300 children) the D(M)FS pooled PF was 24% (95% confidence interval (CI), 21 to 28%; P < 0.0001). In populations with caries increment of 2.6 D(M)FS per year, 1.6 children need to brush with a fluoride toothpaste (rather than a toothpaste) to prevent one D(M)FS. ++ Exclude Provides evidence for use of fluoride toothpaste, limited information on supervised brushing as in Trial
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