Which is the most serious and most Multiple myeloma common of the plasma cell dyscrasias? Patients progress from the monoclonal gammopathy of undetermined asymptomatic ___ to ___ to the significance (MGUS); smoldering multiple myeloma symptomatic disease of multiple (SMM). myeloma. Patients with multiple myeloma bone marrow; bone lesions typically have excess plasma cells in ____ a monoclonal immunoglobulin component in the plasma and/or urine, and lytic _____. True or False: In multiple myeloma True plasma cells infiltrating the bone marrow may be morphologically normal or may show atypical or bizarre cytological features. In multiple myeloma, the IgG (50%) immunoglobulin produced by the malignant clone can be of any type. Which is the most common? In multiple myeloma, the IgA and IgM (light chains only) immunoglobulin produced by the malignant clone can be of any type. After IgG, which 2 are the most common? Why are an excess of free light Very the production of heavy and light chains by chains produced in multiple the malignant plasma cells are not well synchronized myeloma? In what percent of cases do myeloma 10% cells exclusively produce light chains? Free chains are rapidly excreted Urine in ___. What are free immunoglobulin light Jones protein chains (κ or excreted in the urine? λ) True or False: In multiple myeloma, True very rarely, two or more distinct M proteins are produced, or a clinically typical myeloma may produce no secretory product
Which is the most serious and most common of the plasma cell dyscrasias? Multiple myeloma Patients progress from the asymptomatic ___ to ___ to the symptomatic disease of multiple myeloma. monoclonal gammopathy of undetermined significance (MGUS); smoldering multiple myeloma (SMM). Patients with multiple myeloma typically have excess plasma cells in ____ a monoclonal immunoglobulin component in the plasma and/or urine, and lytic _____. bone marrow; bone lesions True or False: In multiple myeloma plasma cells infiltrating the bone marrow may be morphologically normal or may show atypical or bizarre cytological features. True In multiple myeloma, the immunoglobulin produced by the malignant clone can be of any type. Which is the most common? IgG (50%) In multiple myeloma, the immunoglobulin produced by the malignant clone can be of any type. After IgG, which 2 are the most common? IgA and IgM (light chains only) Why are an excess of free light chains produced in multiple myeloma? Very the production of heavy and light chains by the malignant plasma cells are not well synchronized In what percent of cases do myeloma cells exclusively produce light chains? 10% Free chains are rapidly excreted in ___. Urine What are free immunoglobulin light chains (κ or λ) excreted in the urine? Jones protein True or False: In multiple myeloma, very rarely, two or more distinct M proteins are produced, or a clinically typical myeloma may produce no secretory product True
Immuno%20PPT%20Flashcards%20Unit%203.docx