(Liebowitz et Desvenlafaxine 179.0-195.3 No 8 T8 121 56 41.9±12.5 No 21 14 Yes al. 2007)() Placebo 117 65 39.3±12.9 13 7 (Liebowitz et Desvenlafaxine 50 No 8 T8 151 62 43±15 No 14 - Yes al. 2008)() Desvenlafaxine 100 148 53 43±13 15 - Placebo 152 63 42±14 5 - (Lin et al. Sertraline + 50 Yes 10 T10 20 80 35.2 ±10.0 No 0 1 No 2011)() Placebo (Lineberry et al. Bupropion 286.8 No 6 T6 110 - 41.9 No 25 - Yes 1990)() Placebo 109 - 40.8 8 - (Lopez-Ibor et Milnacipran 100 Yes 6 T6 51 74.5 18-70 No 11 - Yes al. 2004)() (Lydiard et al. Sertraline 138.6 No 8 T8 132 64.4 41.2 No 8 14 Yes 1997)() Placebo 129 66.7 40.2 3 7 (Mao et al. Escitalopram 10 Yes 8 T8 118 47.5 37.1±14.1 No - 8 Yes 2008)() Fluoxetine 20 113 61.9 40.7±13.9 - 7 (Marchesi et al. Fluoxetine 20 Yes 10 T10 67 73.1 43.6± 11.9 No - 1 Yes 1998)() (Masco et al. Bupropion + 333 No 6 T6 58 50 46.3 No 6 2 Yes 1994)() Placebo (Mathur et al. Mirtazapine 22. 9±10.5 No 6 T6 18 - - No 1 - No 2002)() (Mathur et al. Citalopram 36.0 ± 16.7 No 6 T6 20 55 - No 0 0 No 2005)()
(Liebowitz et al. 2007)() Desvenlafaxine Placebo 179.0-195.3 No 8 T8 121 117 56 65 41.9±12.5 39.3±12.9 No 21 13 14 7 Yes (Liebowitz et al. 2008)() Desvenlafaxine Desvenlafaxine Placebo 50 100 No 8 T8 151 148 152 62 53 63 43±15 43±13 42±14 No 14 15 5 - - - Yes (Lin et al. 2011)() Sertraline + Placebo 50 Yes 10 T10 20 80 35.2 ±10.0 No 0 1 No (Lineberry et al. 1990)() Bupropion Placebo 286.8 No 6 T6 110 109 - - 41.9 40.8 No 25 8 - - Yes (Lopez-Ibor et al. 2004)() Milnacipran 100 Yes 6 T6 51 74.5 18-70 No 11 - Yes (Lydiard et al. 1997)() Sertraline Placebo 138.6 No 8 T8 132 129 64.4 66.7 41.2 40.2 No 8 3 14 7 Yes (Mao et al. 2008)() Escitalopram Fluoxetine 10 20 Yes 8 T8 118 113 47.5 61.9 37.1±14.1 40.7±13.9 No - - 8 7 Yes (Marchesi et al. 1998)() Fluoxetine 20 Yes 10 T10 67 73.1 43.6± 11.9 No - 1 Yes (Masco et al. 1994)() Bupropion + Placebo 333 No 6 T6 58 50 46.3 No 6 2 Yes (Mathur et al. 2002)() Mirtazapine 22. 9±10.5 No 6 T6 18 - - No 1 - No (Mathur et al. 2005)() Citalopram 36.0 ± 16.7 No 6 T6 20 55 - No 0 0 No
JCP_00_00_2015_03_31_SERRETTI_JCP14173_SDC1.docx