(Hsu et al. Citalopram 22.9 ± 8.5 Yes 6 T6 21 52.4 43.4± 11.4 No 1 1 No 2011)() Sertraline 57.1± 17.9 21 66.7 38.0± 13.8 3 3 (Hudson et al. Duloxetine 30-60 Yes 12+26 T12 533 71.9 43.4± 12.7 Dysthymia 56 72 Yes 2007)() (Isaac et al. Milnacipran + 100 No 6 T6 39 51.3 32.3± 10.0 No 1 - No 2003)() Placebo (Jazayeri et al. Fluoxetine + 20 No 8 T8 16 75 35.1± 9.4 Dysthymia 1 2 No 2008)() Placebo (Jefferson et al. Bupropion 300-450 Yes 8 T8 135 66 40.0 No 10 - Yes 2006)() Placebo 139 69 39.8 2 - (Kamijima et Sertraline 85.0± 24.2 No 8+16 T8 361 60.4 40.4± 10.8 No - 64 Yes al. 2006)() (Kanemoto et Milnacipran 75-150 Yes 8 T8 66 56.1 56.8± 14.1 No - 1 No al. 2004)() (Kang et al. Mirtazapine 27.6 ± 8.6 No 8 T8 73 76.7 46.5± 12.6 No 1 7 Yes 2009)() Venlafaxine 141.4±62.4 53 77.4 47.2± 12.0 0 3 (Kaplan et al. Venlafaxine 142 No 6 or 8 T6 or T8 69 74.0 38.6 No 6 - Yes 2002)() (Kasper et al. Escitalopram 10 Yes 8 T8 170 75 75±7 No 4 4 Yes 2005)() Fluoxetine 20 164 77 75±7 3 0 Placebo 180 76 75±7 4 1 (Kasper et al. Escitalopram 20 No 8 T8 140 68.6 41.6 ±12.6 No 3 0 Yes 2012)() Placebo 71 74.6 42.6 ±11.6 3 0
(Hsu et al. 2011)() Citalopram Sertraline 22.9 ± 8.5 57.1± 17.9 Yes 6 T6 21 21 52.4 66.7 43.4± 11.4 38.0± 13.8 No 1 3 1 3 No (Hudson et al. 2007)() Duloxetine 30-60 Yes 12+26 T12 533 71.9 43.4± 12.7 Dysthymia 56 72 Yes (Isaac et al. 2003)() Milnacipran + Placebo 100 No 6 T6 39 51.3 32.3± 10.0 No 1 - No (Jazayeri et al. 2008)() Fluoxetine + Placebo 20 No 8 T8 16 75 35.1± 9.4 Dysthymia 1 2 No (Jefferson et al. 2006)() Bupropion Placebo 300-450 Yes 8 T8 135 139 66 69 40.0 39.8 No 10 2 - - Yes (Kamijima et al. 2006)() Sertraline 85.0± 24.2 No 8+16 T8 361 60.4 40.4± 10.8 No - 64 Yes (Kanemoto et al. 2004)() Milnacipran 75-150 Yes 8 T8 66 56.1 56.8± 14.1 No - 1 No (Kang et al. 2009)() Mirtazapine Venlafaxine 27.6 ± 8.6 141.4±62.4 No 8 T8 73 53 76.7 77.4 46.5± 12.6 47.2± 12.0 No 1 0 7 3 Yes (Kaplan et al. 2002)() Venlafaxine 142 No 6 or 8 T6 or T8 69 74.0 38.6 No 6 - Yes (Kasper et al. 2005)() Escitalopram Fluoxetine Placebo 10 20 Yes 8 T8 170 164 180 75 77 76 75±7 75±7 75±7 No 4 3 4 4 0 1 Yes (Kasper et al. 2012)() Escitalopram Placebo 20 No 8 T8 140 71 68.6 74.6 41.6 ±12.6 42.6 ±11.6 No 3 3 0 0 Yes
JCP_00_00_2015_03_31_SERRETTI_JCP14173_SDC1.docx