The Search Results I focused on three different forms of non-invasive tools that could help to prevent side effects, as well as the negative impacts these could possibly have. First, I researched nanoparticles that specifically target harmful tumors and can remove tissue for testing. Next, I looked into drug delivery capsules. These both required additional research of how remotely control tools inside of the body functions. Finally, I looked into dissolving surgical screws that only require one surgical procedure, reducing the risk of infection. Researching all of these topics revealed technologies that could be shared among the tools and all would be effective in reducing side effects. Nanoparticles are able to carry non-viral DNA to different cells in the human body. They target cells with mutations such as cancer and use the non-viral DNA to alter the genetic coding of the cell. The non-viral DNA when contained in the polymer was more effective at attacking the malignant tumor than the naked DNA. The nanoparticles more accurately target the tumor in order to lower the dosage of medicine needed and are less toxic than a procedure such as chemotherapy. One type of nanoparticle that is being developed is made from polyethylene glycol which allows the nanoparticle to go undetected by proteins and white blood cells due to its water-like properties. It also has peptides that bind with the specific cell in order to deliver the desired drug.1 Therefore, it is successfully delivered to the correct cell without outside interference. Another type of nanoparticle is created from biodegradable poly esters (IPBAEs). These can be stored for at least two years without losing their efficiency, whereas the ones made from polyethylene glycol were made of a mesh-like net so the drug cannot last as long.2 Doctors found that when the drug was delivered by the nanoparticle it had a much higher concentration in the tumor the day after taking the drug1, 2.
The Search Results I focused on three different forms of non-invasive tools that could help to prevent side effects, as well as the negative impacts these could possibly have. First, I researched nanoparticles that specifically target harmful tumors and can remove tissue for testing. Next, I looked into drug delivery capsules. These both required additional research of how remotely control tools inside of the body functions. Finally, I looked into dissolving surgical screws that only require one surgical procedure, reducing the risk of infection. Researching all of these topics revealed technologies that could be shared among the tools and all would be effective in reducing side effects. Nanoparticles are able to carry non-viral DNA to different cells in the human body. They target cells with mutations such as cancer and use the non-viral DNA to alter the genetic coding of the cell. The non-viral DNA when contained in the polymer was more effective at attacking the malignant tumor than the naked DNA. The nanoparticles more accurately target the tumor in order to lower the dosage of medicine needed and are less toxic than a procedure such as chemotherapy. One type of nanoparticle that is being developed is made from polyethylene glycol which allows the nanoparticle to go undetected by proteins and white blood cells due to its water-like properties. It also has peptides that bind with the specific cell in order to deliver the desired drug.1 Therefore, it is successfully delivered to the correct cell without outside interference. Another type of nanoparticle is created from biodegradable poly esters (IPBAEs). These can be stored for at least two years without losing their efficiency, whereas the ones made from polyethylene glycol were made of a mesh-like net so the drug cannot last as long.2 Doctors found that when the drug was delivered by the nanoparticle it had a much higher concentration in the tumor the day after taking the drug1, 2.
isearch-preventing_side_effects.docx