subsequently dissected into 1mm Benefit: thick slices to facilitated movement Nil of the cryoprotectants (anti-freeze solutions). This is a manual procedure. Freezing of the cortical ovarian tissue The slices of ovarian cortical tissue are exposed to cryoprotectants to remove water from the cells and placed in vials in an automated freezing machine which gradually reduces temperature at a controlled rate over time to °C. The vials are then stored in a large tank containing liquid nitrogen at a temperature below °C. MBS ONC2 Processing and cryopreservation Fee proposal: of semen for fertility preservation $ 495 treatment. Benefit: MBS ON3 Processing and cryopreservation Fee proposal: of testicular tissue for fertility $ 675 preservation treatment. Benefit: Table 3: Summary of Patient Information Comparator Outcomes (PICO) Population Intervention Comparator Outcomes Female MBS ONC1 Health Outcomes Infertility post- patients gonadotoxic Fertility preserved receiving Processing and treatment Miscarriage gonadotoxic cryopreservation Natural Pregnancy treatment of ovarian tissue pregnancy Premature/live/still births for fertility following Increased quality of life preservation treatment with Improved relationship and treatment for gonadotoxic family life female patients. treatment Cost-effectiveness Cost Cost per quality adjusted life year
subsequently dissected into 1mm thick slices to facilitated movement of the cryoprotectants (anti-freeze solutions). This is a manual procedure. Freezing of the cortical ovarian tissue The slices of ovarian cortical tissue are exposed to cryoprotectants to remove water from the cells and placed in vials in an automated freezing machine which gradually reduces temperature at a controlled rate over time to °C. The vials are then stored in a large tank containing liquid nitrogen at a temperature below °C. Benefit: Nil MBS ONC2 Processing and cryopreservation of semen for fertility preservation treatment. Fee proposal: $ 495 Benefit: MBS ON3 Processing and cryopreservation of testicular tissue for fertility preservation treatment. Fee proposal: $ 675 Benefit: Table 3: Summary of Patient Information Comparator Outcomes (PICO) Population Intervention Comparator Outcomes Female patients receiving gonadotoxic treatment MBS ONC1 Processing and cryopreservation of ovarian tissue for fertility preservation treatment for female patients. Infertility post- gonadotoxic treatment Natural pregnancy following treatment with gonadotoxic treatment Health Outcomes Fertility preserved Miscarriage Pregnancy Premature/live/still births Increased quality of life Improved relationship and family life Cost-effectiveness Cost Cost per quality adjusted life year
1435-ConsultationProtocol-Accessible.docx