What binds to cell surface molecules on Monoclonal antibodies. the lymphocytes as induction agents and to treat severe rejection episodes? OKT3 is a monoclonal antibody that CD3 receptor binds to the on human lymphocytes. True or False. False. The binding of OKT3 to the CD3 T-cells surface has one outcome. What may render the affected T cells Binding may modulate CD3 from the cell surface. nonfunctional? How do higher doses of antibody deplete With complement-mediated or opsonization for T cells from circulation? removal by phagocytic cells. What problem is with monoclonal The development of anti-mouse antibodies by the antibody preparations administered to patient. patient? When are two polyclonal anti-T-cell To treat severe rejection. antibody preparations used? Thymoglobulin is a an anti-thymocyte Rabbit. antibody prepared in . ATGAM is a polyclonal antiserum Horses. prepared from immunization of . Name the two immunosuppressive Thymoglobulin and ATGAM. agents that are potent enough to deplete lymphocytes from the circulation. What activity can the development of The activity of the monoclonal antibody. these anti-mouse antibodies interfere with? What is the drawback associated with The development of serum sickness due to antibody administration of polyclonal antibody responses to the foreign immunoglobulin. preparations? What are the two main activities carried HLA typing and HLA antibody out by histocompatibility laboratories in screening/identification. support of transplantation? What is HLA typing? The phenotypic or genotypic definition of the HLA antigens or genes in a transplant candidate or donor. For clinical HLA testing, of Phenotypes or genotypes. the classical transplant antigens or genes are determined (HLA-A, B, Cw, DR, DQ). What information is used to find the Histocomplatibility. most suitable donor–recipient combination from an immunologic standpoint? True or False. False.
What binds to cell surface molecules on the lymphocytes as induction agents and to treat severe rejection episodes? Monoclonal antibodies. OKT3 is a monoclonal antibody that binds to the on human lymphocytes. CD3 receptor True or False. The binding of OKT3 to the CD3 T-cells surface has one outcome. False. What may render the affected T cells nonfunctional? Binding may modulate CD3 from the cell surface. How do higher doses of antibody deplete T cells from circulation? With complement-mediated or opsonization for removal by phagocytic cells. What problem is with monoclonal antibody preparations administered to patient? The development of anti-mouse antibodies by the patient. When are two polyclonal anti-T-cell antibody preparations used? To treat severe rejection. Thymoglobulin is a an anti-thymocyte antibody prepared in . Rabbit. ATGAM is a polyclonal antiserum prepared from immunization of . Horses. Name the two immunosuppressive agents that are potent enough to deplete lymphocytes from the circulation. Thymoglobulin and ATGAM. What activity can the development of these anti-mouse antibodies interfere with? The activity of the monoclonal antibody. What is the drawback associated with administration of polyclonal antibody preparations? The development of serum sickness due to antibody responses to the foreign immunoglobulin. What are the two main activities carried out by histocompatibility laboratories in support of transplantation? HLA typing and HLA antibody screening/identification. What is HLA typing? The phenotypic or genotypic definition of the HLA antigens or genes in a transplant candidate or donor. For clinical HLA testing, of the classical transplant antigens or genes are determined (HLA-A, B, Cw, DR, DQ). Phenotypes or genotypes. What information is used to find the most suitable donor–recipient combination from an immunologic standpoint? Histocomplatibility. True or False. False.
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