(Ansseau et al. Paroxetine 20-30 No 6 T6 56 46.4 43.7± 11.5 No - 5 Yes 1994)() (Appelhof et al. Paroxetine + 30 Yes 8 T8 45 64 46.2±11.2 No 19 21 No 2004)() Placebo (Baldwin et al. Milnacipran 100 No 12 T12 80 80 41.8±10.0 No 10 - Yes 2008)() (Baldwin et al. Duloxetine 60 Yes 8 T8 155 67.7 45.3±12.0 No 13 - Yes 2012)() Placebo 148 69.6 43.4±12.5 6 - (Behnke et al. Mirtazapine 38.3 Yes 8 T8 176 55.7 42 ± 11 No 9 35 Yes 2003)() Sertraline 92.7 169 61.5 41 ± 12 15 13 (Benkert et al. Mirtazapine 32.7 Yes 6 T6 135 63 47.2± 11.1 No - 15 Yes 2000)() Paroxetine 22.9 134 65 47.3± 10.3 - 10 (Benkert et al. Venlafaxine 225 No 6 T6 115 - - No 17 - Yes 2006)() (Benkert et al. Venlafaxine 225 Yes 6 T6 85 69.4 48.9± 11.7 No 8 - No 1996)() (Berk et al. Duloxetine 20 Yes 6 T6 80 77.5 38 No 17 7 No 1997)() (Berzewski et Reboxetine 8-20 Yes 6 T6 130 64.6 45.4± 12.0 No 10 4 No al. 1997)() (Bielski et al. Escitalopram 20 Yes 8 T8 97 69.4 37.3± 12.3 No - 9 Yes 2004)() Venlafaxine 225 98 47 37.5± 11.6 - 17 (Blier et al. Fluoxetine + 20 Yes 6 T6 28 - 43.8 ± 1.8 No 3 3 Yes 2010)() Placebo
(Ansseau et al. 1994)() Paroxetine 20-30 No 6 T6 56 46.4 43.7± 11.5 No - 5 Yes (Appelhof et al. 2004)() Paroxetine + Placebo 30 Yes 8 T8 45 64 46.2±11.2 No 19 21 No (Baldwin et al. 2008)() Milnacipran 100 No 12 T12 80 80 41.8±10.0 No 10 - Yes (Baldwin et al. 2012)() Duloxetine Placebo 60 Yes 8 T8 155 148 67.7 69.6 45.3±12.0 43.4±12.5 No 13 6 - - Yes (Behnke et al. 2003)() Mirtazapine Sertraline 38.3 92.7 Yes 8 T8 176 169 55.7 61.5 42 ± 11 41 ± 12 No 9 15 35 13 Yes (Benkert et al. 2000)() Mirtazapine Paroxetine 32.7 22.9 Yes 6 T6 135 134 63 65 47.2± 11.1 47.3± 10.3 No - - 15 10 Yes (Benkert et al. 2006)() Venlafaxine 225 No 6 T6 115 - - No 17 - Yes (Benkert et al. 1996)() Venlafaxine 225 Yes 6 T6 85 69.4 48.9± 11.7 No 8 - No (Berk et al. 1997)() Duloxetine 20 Yes 6 T6 80 77.5 38 No 17 7 No (Berzewski et al. 1997)() Reboxetine 8-20 Yes 6 T6 130 64.6 45.4± 12.0 No 10 4 No (Bielski et al. 2004)() Escitalopram Venlafaxine 20 225 Yes 8 T8 97 98 69.4 47 37.3± 12.3 37.5± 11.6 No - - 9 17 Yes (Blier et al. 2010)() Fluoxetine + Placebo 20 Yes 6 T6 28 - 43.8 ± 1.8 No 3 3 Yes
JCP_00_00_2015_03_31_SERRETTI_JCP14173_SDC1.docx