14. Prospective Verweij 2013 Blood collected prior to invasive testing. NIPT 21 July 2013 consecutive evaluated after invasive test. Lab staff blind to cohort invasive test result. N = 520 (Netherlands, Sweden). Outcomes: Sensitivity, specificity, rate, false-positive rate, accuracy (risk cut-off 1%) (T21). 15. Nested Ashoor 2012 Blood collected prior to invasive testing. NIPT April 2012 evaluated after invasive test. Lab staff blind to invasive test result. Each case matched to 3 controls for length of sample storage. N = 400 (Netherlands, Sweden, US). Outcomes: Sensitivity, specificity (risk cut-off not reported) (T21, T18). 16. Prospective Sparks 2012b Lab staff not blind (training set) or blind April 2012 (validation set) to invasive test result. N = 338 (UK). Outcomes: Sensitivity, specificity (by risk cut-off) (T21, T18). 17. Case control Nicolaides 2014 Blood collected prior to invasive testing. NIPT February 2014 evaluated after invasive test result. Lab staff blind to invasive test result. N = 177 (UK). Outcomes: Sensitivity (detection rate), positive rate (risk cut-off 1%) (SCA). 18. Case control Hooks 2014 Blood sample collected prior to invasive testing. 20 February 2014 NIPT evaluated after invasive test. Lab staff blind to invasive test result. N = 432 (UK). Outcomes: Sensitivity (detection rate), false-positive rate (risk cut-off not reported) (SCA). Panorama NIPT
14. Prospective consecutive cohort Verweij 2013 Blood collected prior to invasive testing. NIPT evaluated after invasive test. Lab staff blind to invasive test result. N = 520 (Netherlands, Sweden). Outcomes: Sensitivity, specificity, rate, false-positive rate, accuracy (risk cut-off 1%) (T21). 21 July 2013 15. Nested Ashoor 2012 Blood collected prior to invasive testing. NIPT evaluated after invasive test. Lab staff blind to invasive test result. Each case matched to 3 controls for length of sample storage. N = 400 (Netherlands, Sweden, US). Outcomes: Sensitivity, specificity (risk cut-off not reported) (T21, T18). April 2012 16. Prospective Sparks 2012b Lab staff not blind (training set) or blind (validation set) to invasive test result. N = 338 (UK). Outcomes: Sensitivity, specificity (by risk cut-off) (T21, T18). April 2012 17. Case control Nicolaides 2014 Blood collected prior to invasive testing. NIPT evaluated after invasive test result. Lab staff blind to invasive test result. N = 177 (UK). Outcomes: Sensitivity (detection rate), rate (risk cut-off 1%) (SCA). February 2014 18. Case control Hooks 2014 Blood sample collected prior to invasive testing. NIPT evaluated after invasive test. Lab staff blind to invasive test result. N = 432 (UK). Outcomes: Sensitivity (detection rate), false-positive rate (risk cut-off not reported) (SCA). 20 February 2014 Panorama NIPT positive
1461-MSAC-Application-redacted.docx