C4, C5 BBP Rat: Two generation study 400: atrophy of testis, seminal vesicle and Rat: epididymis 100: body weight and AGD ↓ C4 (ring) DCHP Rat: Rat: 80-107 (m-f): sperm head counts and 80-107 (m-f): AGD & retained nipples in F2 males ↓ ↓ focal seminiferous tubule atrophy in F1 males C5-6 DIHP No data No data C6 DnHP 380: number of litters/pair, live 380: pup mortality ↓ ↑ pups/litter and proportion of pups born alive C6-rich DiHepP Developmental study: 419-1360 (m-f): reproductive ↓ 750: resorptions and malformations organ ↑ weight Two generation study: 222-750 (m-f): AGD in F2 ↓ C6 DEHP 140: fertility 14: testes wt, seminiferous tubule atrophy ↓ ↓ C7 DIOP No data No data C8 DnOP NE NE C7-9 Di-C7-9 NE 1000: skeletal variations (lumbar ribs) ↑ PE C8, C9 DINP Rat: Two generation study: Rat: 966: live birth and survival indices ↓ 159-395 (m-f): pup weight at weaning ↓ Mouse: Developmental study: 742 (m): testes weight ↓ Rat: 750: areolas/nipples in males; male reproductive ↑ ↑ malformations 1000: skeletal and visceral variations ↑
C4, C5 BBP Rat: 400: atrophy of testis, seminal vesicle and epididymis Two generation study Rat: 100: ↓ body weight and AGD C4 (ring) DCHP Rat: 80-107 (m-f): ↓ sperm head counts and focal seminiferous tubule atrophy in F1 males Rat: 80-107 (m-f): ↓ AGD & retained nipples in F2 males C5-6 DIHP No data No data C6 DnHP 380: ↓ number of litters/pair, live pups/litter and proportion of pups born alive 380: ↑ pup mortality C6-rich DiHepP 419-1360 (m-f): ↓ reproductive organ weight Developmental study: 750: ↑ resorptions and malformations Two generation study: 222-750 (m-f): ↓ AGD in F2 C6 DEHP 140: ↓ fertility 14: ↓ testes wt, seminiferous tubule atrophy C7 DIOP No data No data C8 DnOP NE NE C7-9 Di-C7-9 PE NE 1000: ↑ skeletal variations (lumbar ribs) C8, C9 DINP Rat: 966: ↓ live birth and survival indices Mouse: 742 (m): ↓ testes weight Two generation study: Rat: 159-395 (m-f): ↓ pup weight at weaning Developmental study: Rat: 750: ↑ areolas/nipples in males; ↑ male reproductive malformations 1000: ↑ skeletal and visceral variations
Phthalates-hazard-compendium.docx