Method Strengths Limitations Expected Relevance Recommended variability and and Fit for for CFP & Food Food Code Code (H/M/L) ASTM vitro” test, relatively vitro” test (i.e. results will Results more High: Good Yes “In “In E2783 inexpensive, can be run with not necessarily predict real variable when screening (Time Kill) many organisms and by many world hand hygiene results or the product test, should labs with good the in-vivo methods) has high foam; be required reproducibility. results are as a means highly to ensure Large amount of data and dependent of broad experience using this method the mixing spectrum technique antimicrobial effectiveness before “in vivo” testing. Chlorine vitro” test. Long history of posed by working with S. Products with Low No “In use (typhoid fever) border line Equivalency typhi efficacy have Data is not relevant for hand high variability antiseptics in general, in results especially those that do not contain halogen based active ingredients EN 1276 vitro” test Some of microorganisms are No Low No “In not relevant for food retail Includes options of to be use added, based on the industry. Could be tested for clean and The test method is not dirty conditions designed for chemistries affected by soil
Method Strengths Limitations Expected variability and Relevance and Fit for Food Code (H/M/L) Recommended for CFP & Food Code ASTM E2783 (Time Kill) “In vitro” test, relatively inexpensive, can be run with many organisms and by many labs with good reproducibility. Large amount of data and experience using this method “In vitro” test (i.e. results will not necessarily predict real world hand hygiene results or the in-vivo methods) Results more variable when the product has high foam; results are highly dependent of the mixing technique High: Good screening test, should be required as a means to ensure broad spectrum antimicrobial effectiveness before “in vivo” testing. Yes Chlorine Equivalency “In vitro” test. Long history of use posed by working with S. typhi (typhoid fever) Data is not relevant for hand antiseptics in general, especially those that do not contain halogen based active ingredients Products with border line efficacy have high variability in results Low No EN 1276 “In vitro” test Includes options of to be added, based on the industry. Could be tested for clean and dirty conditions Some of microorganisms are not relevant for food retail use The test method is not designed for chemistries affected by soil No Low No
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