In multiple myeloma, compare the The of normal immunoglobulin is often level of normal immunoglobulin to decreased in proportion to the amount of M protein the amount of M protein present in present in the serum the serum The clinical manifestations of Hematologic, skeletal, and immunologic. multiple myeloma are primarily ___, ___ and ___. What percent of patients with 15% multiple myeloma develop chain deposition disease or amyloidosis What two related disorders have free deposition disease and amyloidosis light chains or fragments of immunoglobulin deposited in the tissues? How do amyloid fibers stained with Apple-green birefringence the dye Congo red appear when viewed under a polarizing microscope? Deposits of light chains in multiple Tissue sections; immunofluorescence or myeloma can be identified in what immunohistochemical staining with specific specimens? With what techniques? antibodies. Criteria for the diagnosis of multiple plasma cells constituting greater than 10 percent of myeloma include? bone marrow cells or a plasmacytoma (a solid tumor mass of plasma cells), plus either serum M protein greater than 3g/dL, urinary M protein, or osteolytic bone lesions. M proteins can be detected in serum electrophoresis and immunofixation or urine by what 2 methods? An important feature supporting the Bence Jones protein diagnosis of multiple myeloma is the presence of this protein in urine Free light chains can be detected in electrophoresis and immunofixation serum or urine by what 2 methods? What disease is a malignant Waldenström’s macroglobulinemia proliferation of IgM-producing lymphocytes and corresponds to lymphoplasmacytoid lymphoma as defined by the WHO? Describe the malignant cells of Malignant cells are more immature than plasma cells Waldenström’s macroglobulinemia and have a microscopic appearance somewhere between that of small lymphocytes and plasma cells. The clinical signs and symptoms of Infiltration of the malignant cells into bone marrow, Waldenström’s macroglobulinemia the spleen, and lymph nodes with the overproduction are? of monoclonal IgM
In multiple myeloma, compare the level of normal immunoglobulin to the amount of M protein present in the serum The of normal immunoglobulin is often decreased in proportion to the amount of M protein present in the serum The clinical manifestations of multiple myeloma are primarily ___, ___ and ___. Hematologic, skeletal, and immunologic. What percent of patients with multiple myeloma develop deposition disease or amyloidosis 15% What two related disorders have free light chains or fragments of immunoglobulin deposited in the tissues? deposition disease and amyloidosis How do amyloid fibers stained with the dye Congo red appear when viewed under a polarizing microscope? Apple-green birefringence Deposits of light chains in multiple myeloma can be identified in what specimens? With what techniques? Tissue sections; immunofluorescence or immunohistochemical staining with specific antibodies. Criteria for the diagnosis of multiple myeloma include? plasma cells constituting greater than 10 percent of bone marrow cells or a plasmacytoma (a solid tumor mass of plasma cells), plus either serum M protein greater than 3g/dL, urinary M protein, or osteolytic bone lesions. M proteins can be detected in serum or urine by what 2 methods? electrophoresis and immunofixation An important feature supporting the diagnosis of multiple myeloma is the presence of this protein in urine Bence Jones protein Free light chains can be detected in serum or urine by what 2 methods? electrophoresis and immunofixation What disease is a malignant proliferation of IgM-producing lymphocytes and corresponds to lymphoplasmacytoid lymphoma as defined by the WHO? Waldenström’s macroglobulinemia Describe the malignant cells of Waldenström’s macroglobulinemia Malignant cells are more immature than plasma cells and have a microscopic appearance somewhere between that of small lymphocytes and plasma cells. The clinical signs and symptoms of Waldenström’s macroglobulinemia are? Infiltration of the malignant cells into bone marrow, the spleen, and lymph nodes with the overproduction of monoclonal IgM chain
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