69 patients treated for HBO2 + HBO2: 94 min sessions Time points: baseline, 24 hours Not reported. Data in this study can be summarized by the (0) severe TBI (defined as Standard care of 100% FiO2 at 1.5 ATA following 7 major points: 1) Hyperbaric O2 201028 GCS of 8 or less) at 26(ND) daily x 3 sessions VITAL SIGNS: Intracranial Pressure (ICP). had a significantly greater positive Hennepin County Compression: 17 min; ICP was significantly lower statistically after effect than NBH on oxidative Rockswold, Medical Center, after Normobaric Plateau 60 min; HBO2 until the next treatment session (p < cerebral metabolism and ICP. 2) Although resuscitation (58M, 11F) hyperoxia + Decompression: 17 min. 0.001) in comparison with levels in the the treatment effect was not an with a mean age of 35 Standard care control group. The post-treatment effect phenomenon, a critical brain tissue +/- NDa (NBH) 21(ND) 1) NBH: 3-hour sessions was the same for all 3 days. The NBH pressure of oxygen (PO2) level of 200 mm Hg of 100% FiO2 at 1 ATA group’s ICP measures did not differ seemed important to achieve a robust Standard care x 3 sessions significantly from those in the control positive effect on cerebral metabolism, 22(ND)e group following each treatment session. especially cerebral metabolic rate for oxygen 2) Standard care: (CMRO2), which reflects mitochondrial Intensive neurosurgical function. Brain tissue PO2 monitoring to care closely paralleling determine O2 delivery in the injured brain Brain Trauma during O2 therapy appeared to be important Foundation’s as well. 3) Hyperbaric O2 had a for the effect lasting at least 6 hours, “Guidelines Management of Severe which means that HBO2 can be delivered TBI, 3rd Edition”, intermittently to maintain the treatment including stabilization effect over many days and reduce potential with early intubation, O2 toxicity. 4) The treatment effect was as surgical evacuation of great on Day 3 as it was in the first 24 hours significant hematomas, that is, the treatment effect was the same
Rockswold, 201028 69 patients treated for severe TBI (defined as GCS of 8 or less) at Hennepin County Medical Center, after resuscitation (58M, 11F) with a mean age of 35 +/- NDa HBO2 + Standard care 26(ND) Normobaric hyperoxia + Standard care (NBH) 21(ND) Standard care 22(ND)e HBO2: 94 min sessions of 100% FiO2 at 1.5 ATA daily x 3 sessions Compression: 17 min; Plateau 60 min; Decompression: 17 min. 1) NBH: 3-hour sessions of 100% FiO2 at 1 ATA x 3 sessions 2) Standard care: Intensive neurosurgical care closely paralleling Brain Trauma Foundation’s “Guidelines for the Management of Severe TBI, 3rd Edition”, including stabilization with early intubation, surgical evacuation of significant hematomas, Time points: baseline, 24 hours VITAL SIGNS: Intracranial Pressure (ICP). ICP was significantly lower statistically after HBO2 until the next treatment session (p < 0.001) in comparison with levels in the control group. The post-treatment effect was the same for all 3 days. The NBH group’s ICP measures did not differ significantly from those in the control group following each treatment session. Not reported. Data in this study can be summarized by the following 7 major points: 1) Hyperbaric O2 had a significantly greater positive effect than NBH on oxidative cerebral metabolism and ICP. 2) Although the treatment effect was not an phenomenon, a critical brain tissue pressure of oxygen (PO2) level of 200 mm Hg seemed important to achieve a robust positive effect on cerebral metabolism, especially cerebral metabolic rate for oxygen (CMRO2), which reflects mitochondrial function. Brain tissue PO2 monitoring to determine O2 delivery in the injured brain during O2 therapy appeared to be important as well. 3) Hyperbaric O2 had a effect lasting at least 6 hours, which means that HBO2 can be delivered intermittently to maintain the treatment effect over many days and reduce potential O2 toxicity. 4) The treatment effect was as great on Day 3 as it was in the first 24 hours that is, the treatment effect was the same (0)
JHTR_1_1_2016_08_18_CRAWFORD_1_SDC1.docx