What are one or more shared features of the 1) Cytogenetic abnormalities multipotent hematopoietic stem cells (CD 34) in 2) Overproduction of one or more types of MPNs blood cells with dominance of a transformed clone 3) Hypercellular marrow or marrow fibrosis 4) Thrombotic and/or hemorrhagic bleeding 5) Extramedullary hematopoiesis 6) Transformation to acute leukemia Which of the following MPNs characteristics Primary myelofibrosis is also known as agnogenic myeloid metaplasia or myelofibrosis with myeloid metaplasia ? 1. Choronic myelogenous leukemia (CML) 2. Polycythemia rubra vera 3. Primary myelofibrosis 4. Essential thrombocythemia 2008 who classification of myeloid Neoplasms Tyrosine kinase mutation ? Janus kinase mutation What is the primarily neoplasms age of MPNs 50 to 70 in adults ? What is the spent phase found in It is the halting of all blood cell production myeloproliferative disorder ? in the marrow and the increase in fibrosis What condition do myeloproliferative Acute leukemia disorders transform to ? A mutation in Jak2 is associated with which Polycythemia vera, essential types of myeoloproliferative conditions? thrombocythemia, Primary myeolfibrosis Is maturation in in myeloprolife rative Yes there is effective maturation leading to –tact disorder? increased peripheral blood counts Descrive chronic myelogenous leukemia Is an MPN that originates in an abnormal (CML) pluripotent bone marrow stem cell and is consistently associated with the BCR 1 –ABL fusion gene located in the Philadelphia chromosome What are the other principal types of chronic CML and chronic lymphocytic leukemia leukemia ? What two genes are commonly mutated in Activating JAK2 mutations and MPL primary myelofibrosis? True or false ? CML is a clonal proliferative True disorder of the pluripotent hematopoietic progenitor cell that resulrs in a disordered
What are one or more shared features of the multipotent hematopoietic stem cells (CD 34) in MPNs 1) Cytogenetic abnormalities 2) Overproduction of one or more types of blood cells with dominance of a transformed clone 3) Hypercellular marrow or marrow fibrosis 4) Thrombotic and/or hemorrhagic bleeding 5) Extramedullary hematopoiesis 6) Transformation to acute leukemia Which of the following MPNs characteristics is also known as agnogenic myeloid metaplasia or myelofibrosis with myeloid metaplasia ? 1. Choronic myelogenous leukemia (CML) 2. Polycythemia rubra vera 3. Primary myelofibrosis 4. Essential thrombocythemia Primary myelofibrosis 2008 who classification of myeloid Neoplasms ? Tyrosine kinase mutation Janus kinase mutation What is the primarily neoplasms age of MPNs in adults ? 50 to 70 What is the spent phase found in myeloproliferative disorder ? It is the halting of all blood cell production in the marrow and the increase in fibrosis What condition do myeloproliferative disorders transform to ? Acute leukemia A mutation in Jak2 is associated with which types of myeoloproliferative conditions? Polycythemia vera, essential thrombocythemia, Primary myeolfibrosis Is maturation in –tact in myeloprolife rative disorder? Yes there is effective maturation leading to increased peripheral blood counts Descrive chronic myelogenous leukemia (CML) Is an MPN that originates in an abnormal pluripotent bone marrow stem cell and is consistently associated with the BCR –ABL 1 fusion gene located in the Philadelphia chromosome What are the other principal types of chronic leukemia ? CML and chronic lymphocytic leukemia What two genes are commonly mutated in primary myelofibrosis? Activating JAK2 mutations and MPL True or false ? CML is a clonal proliferative disorder of the pluripotent hematopoietic progenitor cell that resulrs in a disordered True
Hematology%20PPT%20Flashcards%20Unit%203.docx