(Stahl et al. Agomelatine 50 No 8 T8 167 63.9 43.8 ±12.0 No 11 30 Yes 2010)() Placebo 165 64.5 43.0±13.1 10 7 (Steen et al. Milnacipran 200 No 6+20 T6 30 30 48.1 ±15.2 No 10 - No 1997)() (Steffens et al. Bupropion IR or 250-258 No 12 T12 15 - - No 1 - Yes 2001)() SR (Stewart et al. Duloxetine 74±44 No 8 T8 20 55 35 ± 12 Dysthymia. PD 3 3 Yes 2008)() (Stuppaeck et Paroxetine 33.3 No 6 T6 78 70.5 47.5± 11.6 No 8 3 Yes al. 1994)() (Taner et al. Fluoxetine 20-40 No 8 T8 21 78.4 36.8± 11.0 No 1 - No 2006)() Reboxetine 8-10 22 78.4 36.8± 11.0 4 - (Taragano et al. Sertraline 50-100 No 8 T8 469 73 57.4± 13.9 No 9 5 Yes 1999)() (Thase et al. Venlafaxine 75-225 Yes 8 T8 95 63.2 40±11 No 33 26 Yes 1997)() Placebo 102 59.8 42±12 15 11 et al. Fluoxetine 37.2 No 6 T6 106 72 42.9±12.1 No 22 18 Yes 1997)() (Thase et al. Citalopram 23.9 No 6 T6 61 52.5 43.0±11.9 No 1 5 No 2002)() (Thase et al. Bupropion 299.6±77.1 No 12 T12 168 56 37.1± 12.3 No - 2 Yes 2006)() Venlafaxine 149.8±41.3 174 64 37.4± 11.6 - 12 (Tollefson et al. Fluoxetine 20-40 No 8 T8 62 71 40.1± 11.7 No 19 - Yes 1994)()
(Stahl et al. 2010)() Agomelatine Placebo 50 No 8 T8 167 165 63.9 64.5 43.8 ±12.0 43.0±13.1 No 11 10 30 7 Yes (Steen et al. 1997)() Milnacipran 200 No 6+20 T6 30 30 48.1 ±15.2 No 10 - No (Steffens et al. 2001)() Bupropion IR or SR 250-258 No 12 T12 15 - - No 1 - Yes (Stewart et al. 2008)() Duloxetine 74±44 No 8 T8 20 55 35 ± 12 Dysthymia. PD 3 3 Yes (Stuppaeck et al. 1994)() Paroxetine 33.3 No 6 T6 78 70.5 47.5± 11.6 No 8 3 Yes (Taner et al. 2006)() Fluoxetine Reboxetine 20-40 8-10 No 8 T8 21 22 78.4 78.4 36.8± 11.0 36.8± 11.0 No 1 4 - - No (Taragano et al. 1999)() Sertraline 50-100 No 8 T8 469 73 57.4± 13.9 No 9 5 Yes (Thase et al. 1997)() Venlafaxine Placebo 75-225 Yes 8 T8 95 102 63.2 59.8 40±11 42±12 No 33 15 26 11 Yes et al. 1997)() Fluoxetine 37.2 No 6 T6 106 72 42.9±12.1 No 22 18 Yes (Thase et al. 2002)() Citalopram 23.9 No 6 T6 61 52.5 43.0±11.9 No 1 5 No (Thase et al. 2006)() Bupropion Venlafaxine 299.6±77.1 149.8±41.3 No 12 T12 168 174 56 64 37.1± 12.3 37.4± 11.6 No - - 2 12 Yes (Tollefson et al. 1994)() Fluoxetine 20-40 No 8 T8 62 71 40.1± 11.7 No 19 - Yes
JCP_00_00_2015_03_31_SERRETTI_JCP14173_SDC1.docx