THC in vivo []. However, the THC-V concentrations used to produce an antagonistic response are at least 100-1000 times higher than what would be reasonably absorbed during smoking of a typical joint. CBC, another trace non-psychotropic phytocannabinoid appears to modulate the effect of THC by inhibiting endocannabinoid cellular reuptake, and is also a potent activator of TRPA1 receptors, with apparent analgesic [] and anti-inflammatory effects [,]. However, like CBD, the trend for maximising THC production may have led to marginalisation of CBC as historically, CBC has sometimes been reported to be the second or third most abundant cannabinoid []. Some limitations inherent in the data presented here should be acknowledged. Due to funding constraints we could not collect a very large random or necessarily representative sample of Cannabis Cautioning seizures. However, we did ensure the samples we obtained came from the major rural cannabis growing areas on the NSW north coast and the major urban areas of the state. Further, as both Cannabis Cautioning and Known Provenance samples were not required to be retained for criminal proceedings, we received and stored them soon after they were seized. The freshness of the samples is confirmed by the dominance of carboxylic acid forms of THC, CBD and CBG, and very low levels of CBN, the main oxidation product of THC. Given the known variability of THC within a single plant [3], it is possible that these results do not represent the “true” average potency of each plant as buds were used whenever possible from samples that were analyzed. However, there were strong positive
THC in vivo []. However, the THC-V concentrations used to produce an antagonistic response are at least 100-1000 times higher than what would be reasonably absorbed during smoking of a typical joint. CBC, another trace non-psychotropic phytocannabinoid appears to modulate the effect of THC by inhibiting endocannabinoid cellular reuptake, and is also a potent activator of TRPA1 receptors, with apparent analgesic [] and anti-inflammatory effects [,]. However, like CBD, the trend for maximising THC production may have led to marginalisation of CBC as historically, CBC has sometimes been reported to be the second or third most abundant cannabinoid []. Some limitations inherent in the data presented here should be acknowledged. Due to funding constraints we could not collect a very large random or necessarily representative sample of Cannabis Cautioning seizures. However, we did ensure the samples we obtained came from the major rural cannabis growing areas on the NSW north coast and the major urban areas of the state. Further, as both Cannabis Cautioning and Known Provenance samples were not required to be retained for criminal proceedings, we received and stored them soon after they were seized. The freshness of the samples is confirmed by the dominance of carboxylic acid forms of THC, CBD and CBG, and very low levels of CBN, the main oxidation product of THC. Given the known variability of THC within a single plant [3], it is possible that these results do not represent the “true” average potency of each plant as buds were used whenever possible from samples that were analyzed. However, there were strong positive
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