Describe any new information regarding the phenotype, including adverse events, during the annual review. References: Bloom, F., Brown, M. (Eds). (2003). Guidelines for the care and use of mammals in neuroscience and behavioral research. Washington DC: The National Academies Press. Appendix 1: Definition and Examples of USDA Pain and Distress Categories Category B Category C Category D Category E Animals being bred, acclimatized, Animals that are subject Animals subjected to Animals subjected to or held for use in teaching, testing, to procedures that cause potentially painful or potentially painful or experiments, research, or surgery, no pain or distress, or stressful procedures for stressful procedures that but not yet used for such purposes. only momentary or slight which they receive are not alleviated with Non‐invasive observation of pain or distress and do appropriate anesthetics, anesthetics, analgesics animals in the wild. not require the use of analgesics and/or and/or tranquilizer drugs. pain‐relieving drugs. tranquilizer drugs. Withholding anesthesia/analgesia must be scientifically justified in the protocol and be approved by the IACUC. Example Examples Examples Examples
Describe any new information regarding the phenotype, including adverse events, during the annual review. References: Bloom, F., Brown, M. (Eds). (2003). Guidelines for the care and use of mammals in neuroscience and behavioral research. Washington DC: The National Academies Press. Appendix 1: Definition and Examples of USDA Pain and Distress Categories Category B Category C Category D Category E Animals being bred, acclimatized, or held for use in teaching, testing, experiments, research, or surgery, but not yet used for such purposes. Non‐invasive observation of animals in the wild. Animals that are subject to procedures that cause no pain or distress, or only momentary or slight pain or distress and do not require the use of pain‐relieving drugs. Animals subjected to potentially painful or stressful procedures for which they receive appropriate anesthetics, analgesics and/or tranquilizer drugs. Animals subjected to potentially painful or stressful procedures that are not alleviated with anesthetics, analgesics and/or tranquilizer drugs. Withholding anesthesia/analgesia must be scientifically justified in the protocol and be approved by the IACUC. Example Examples Examples Examples
IACUC%20Policy%20320%20Guidelines%20for%20Assigning%20Animals%20into%20USDA%20Pain%20and%20Distress%20Categories.docx