Hepatic Fibrosis 4.50E+00 7.56E-02 NaN / Hepatic Stellate Cell Activation Acute Phase 4.24E+00 7.64E-02 0.000 Response Signaling Intrinsic 3.82E+00 1.85E-01 -2.000 Prothrombin Activation Pathway Extrinsic 2.47E+00 1.88E-01 NaN F5,TFPI,THBD Prothrombin Activation Pathway Coagulation 2.34E+00 1.14E-01 0.000 F5,TFPI,THBD,SERPIND1 System Atherosclerosis 2.23E+00 6.31E-02 NaN Signaling Dendritic Cell 2.11E+00 5.48E-02 -1.890 Maturation IGF-1 Signaling 2.02E+00 6.45E-02 NaN Supplemental Figures Supplemental Figure 1. Effects of Nano-Orz on gene expressions related to inflammation and ER stress in mesenteric fat from mice ob/ob (A-C) Expression levels of mRNA for MCP-1 (A), Chop, ERdj4, Xbp1s TNFα, IL-6, (B), and in mesenteric fat (n = 8). The mRNA levels were determined by PPARγ2 (C) real-time PCR and normalized by those of Data are expressed as mean ± SEM. * Rn18s. < 0.05, ** < 0.01, vehicle-treated mice (Veh). P P vs Supplemental Figure 2.
Hepatic Fibrosis / Hepatic Stellate Cell Activation 4.50E+00 7.56E-02 NaN Acute Phase Response Signaling 4.24E+00 7.64E-02 0.000 Intrinsic Prothrombin Activation Pathway 3.82E+00 1.85E-01 -2.000 Extrinsic Prothrombin Activation Pathway 2.47E+00 1.88E-01 NaN F5,TFPI,THBD Coagulation System 2.34E+00 1.14E-01 0.000 F5,TFPI,THBD,SERPIND1 Atherosclerosis Signaling 2.23E+00 6.31E-02 NaN Dendritic Cell Maturation 2.11E+00 5.48E-02 -1.890 IGF-1 Signaling 2.02E+00 6.45E-02 NaN Supplemental Figures Supplemental Figure 1. Effects of Nano-Orz on gene expressions related to inflammation and ER stress in mesenteric fat from ob/ob mice (A-C) Expression levels of mRNA for TNFα, IL-6, MCP-1 (A), Chop, ERdj4, Xbp1s (B), and PPARγ2 (C) in mesenteric fat (n = 8). The mRNA levels were determined by real-time PCR and normalized by those of Rn18s. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, vs vehicle-treated mice (Veh). Supplemental Figure 2.
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