Table 6.9. Comparisons of the operating characteristics of four types of dose response curve using Bayesian NDLM model in the adaptive design settings. Weak prior was used in the calculation with adaptive allocation. True Dose Response Dose Level (mg/kg) 0.03 0.3 3 10 20 30 Mean allocation Flat placebo like curve 7.3 7.3 7.3 7.3 7.3 7.3 Emax like Curve 4.6 4.7 4.7 4.6 4.7 4.7 Log Linear Curve 4.9 4.9 4.9 4.9 4.9 5.0 U-Shaped Curve 5.3 5.3 5.3 5.3 5.4 5.4 Proportion of simulation being selected as ED90 Flat placebo like curve 18% 17% 18% 13% 13% 14% Emax like Curve 1% 2% 15% 24% 33% 25% Log Linear Curve 2% 3% 6% 13% 28% 48% U-Shaped Curve 4% 38% 44% 7% 6% 2% Proportion of simulation being selected as MED Flat placebo like curve 0% 0% 0% 0% 0% 0% Emax like Curve 24% 18% 33% 15% 6% 2% Log Linear Curve 25% 16% 16% 16% 15% 6% U-Shaped Curve 22% 51% 16% 1% 0% 0% Proportion of simulation being selected as MAX Flat placebo like curve 16% 17% 19% 15% 14% 18% Emax like Curve 0% 1% 11% 20% 35% 33% Log Linear Curve 1% 2% 4% 10% 27% 56% U-Shaped Curve 2% 32% 46% 10% 8% 3% Probability of dose compared to control Flat placebo like curve 51% 51% 52% 50% 50% 51% Emax like Curve 58% 66% 87% 91% 94% 93% Log Linear Curve 58% 64% 74% 83% 90% 95% U-Shaped Curve 61% 89% 93% 79% 72% 56%
Table 6.9. Comparisons of the operating characteristics of four types of dose response curve using Bayesian NDLM model in the adaptive design settings. Weak prior was used in the calculation with adaptive allocation. True Dose Response Dose Level (mg/kg) 0.03 0.3 3 10 20 30 Mean allocation Flat placebo like curve 7.3 7.3 7.3 7.3 7.3 7.3 Emax like Curve 4.6 4.7 4.7 4.6 4.7 4.7 Log Linear Curve 4.9 4.9 4.9 4.9 4.9 5.0 U-Shaped Curve 5.3 5.3 5.3 5.3 5.4 5.4 Proportion of simulation being selected as ED90 Flat placebo like curve 18% 17% 18% 13% 13% 14% Emax like Curve 1% 2% 15% 24% 33% 25% Log Linear Curve 2% 3% 6% 13% 28% 48% U-Shaped Curve 4% 38% 44% 7% 6% 2% Proportion of simulation being selected as MED Flat placebo like curve 0% 0% 0% 0% 0% 0% Emax like Curve 24% 18% 33% 15% 6% 2% Log Linear Curve 25% 16% 16% 16% 15% 6% U-Shaped Curve 22% 51% 16% 1% 0% 0% Proportion of simulation being selected as MAX Flat placebo like curve 16% 17% 19% 15% 14% 18% Emax like Curve 0% 1% 11% 20% 35% 33% Log Linear Curve 1% 2% 4% 10% 27% 56% U-Shaped Curve 2% 32% 46% 10% 8% 3% Probability of dose compared to control Flat placebo like curve 51% 51% 52% 50% 50% 51% Emax like Curve 58% 66% 87% 91% 94% 93% Log Linear Curve 58% 64% 74% 83% 90% 95% U-Shaped Curve 61% 89% 93% 79% 72% 56%
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