742 (m); NOAEL = 112 (f) & 275 (m); Hepatocellular ↑ adenomas and carcinomas combined. Positive in vitro (1 of 7 studies). C9 DNP Rat: Insufficient Insufficient Unlikely to be Insufficient data. > 2000 data data genotoxic C6-10 Di-C6-10 Rat: ME ME Unlikely to be Rat: Negative in vitro. Rat: Rat: PE >2000 genotoxic LOAEL = 45; 450 (F0): 450: Litter No NOAEL ↓ Seminal vesicle ↓ survival, ↓ assigned; Liver, weight pup kidney. weight C9-11 Di-C9-11 Rat: negative negative negative Unlikely to be Rat: NE Rat: PE >6200 genotoxic LOAEL = 1000; 500: NOAEL = 500; – Skeletal ↑ 19700 Liver variations (lumbar ribs). C9, C10 DIDP Rat: Rat: Rat, 4h: ME ME negative Non-genotoxic Rat: Positive in vitro (1 of NE 134-352: ↓ >29100 >2910 >12.54 LOAEL = 120; 2 studies). Pup NOAEL = 60; survival in F2 Liver, kidney Dog: LOAEL=75 mg/kg bw/d: liver weight ↑ (low reliability study) C10 DIUP Rat: negative Unlikely to be Negative in vitro. >15800 genotoxic C11 DUP Rat: Rat, 6h: negative ME negative Non-genotoxic Rat: >15800 >1.8 LOAEL = 1145; NOAEL = 282; Liver, kidney C12-rich DITDP Rat: Rabbit: ME ME negative Unlikely to be >10000 >3160 genotoxic C13 DTDP Rat: Non-genotoxic Rat: NE NE
742 (m); NOAEL = 112 (f) & 275 (m); ↑ Hepatocellular adenomas and carcinomas combined. Positive in vitro (1 of 7 studies). C9 DNP Rat: > 2000 Insufficient data Insufficient data Unlikely to be genotoxic Insufficient data. C6-10 Di-C6-10 PE Rat: >2000 ME ME Unlikely to be genotoxic Rat: LOAEL = 45; No NOAEL assigned; Liver, kidney. Negative in vitro. Rat: 450 (F0): ↓ Seminal vesicle weight Rat: 450: ↓ Litter survival, ↓ pup weight C9-11 Di-C9-11 PE Rat: >6200 – 19700 negative negative negative Unlikely to be genotoxic Rat: LOAEL = 1000; NOAEL = 500; Liver NE Rat: 500: ↑ Skeletal variations (lumbar ribs). C9, C10 DIDP Rat: >29100 Rat: >2910 Rat, 4h: >12.54 ME ME negative Non-genotoxic Rat: LOAEL = 120; NOAEL = 60; Liver, kidney Dog: LOAEL=75 mg/kg bw/d: ↑ liver weight (low reliability study) Positive in vitro (1 of 2 studies). NE 134-352: ↓ Pup survival in F2 C10 DIUP Rat: >15800 negative Unlikely to be genotoxic Negative in vitro. C11 DUP Rat: >15800 Rat, 6h: >1.8 negative ME negative Non-genotoxic Rat: LOAEL = 1145; NOAEL = 282; Liver, kidney C12-rich DITDP Rat: >10000 Rabbit: >3160 ME ME negative Unlikely to be genotoxic C13 DTDP Rat: Non-genotoxic Rat: NE NE
Phthalates-hazard-compendium.docx