N-cadherin Structure of N-cadherin cell-cell adhesion molecule N-cadherin is a member of a Ca2+-dependent cell-cell adhesion receptor family known as cadherin 2, containing extracellular domain, transmembrane domain and cytoplasmic domain (Figure 1.8). The extracellular domain of N-cadherin contains five extracellular repeats of ~110 amino acids each. The cytoplasmic domain directly binds to p120 catenin, and cleaved by protein and translocate the β-catenin α-catenin γ-secretase carboxy-terminal fragment of N-cadherin with to the nucleus (Figure 1.9). β-catenin Cleaved N-cadherin mediates signalling pathway following cell-cell adhesion (, ). N-cadherin expression in bone cells Within the skeleton there are four basic types of bone cells; osteoclasts, osteoblast, bone lining cells and osteocytes. Mbalaviele et al (1995) showed that E-cadherin was expressed by osteoclasts, but no expression of N-cadherin was detected in these cells (). In osteoblasts, Ferrari et al (2000) demonstrated that N-cadherin was expressed and this was increased during osteoblastogenesis. This study suggested a role for in the late stage of osteoblast differentiation (). Kawaguchi et al (2001) also showed that N-cadherin was expressed by osteoblasts and this expression was increased during osteoblastogenesis (). Marie (2002) demonstrated that the marked increases in
N-cadherin Structure of N-cadherin cell-cell adhesion molecule N-cadherin is a member of a Ca2+-dependent cell-cell adhesion receptor family known as cadherin 2, containing extracellular domain, transmembrane domain and cytoplasmic domain (Figure 1.8). The extracellular domain of N-cadherin contains five extracellular repeats of ~110 amino acids each. The cytoplasmic domain directly binds to p120 catenin, β-catenin and α-catenin cleaved by γ-secretase protein and translocate the carboxy-terminal fragment of N-cadherin with β-catenin to the nucleus (Figure 1.9). Cleaved N-cadherin mediates signalling pathway following cell-cell adhesion (, ). N-cadherin expression in bone cells Within the skeleton there are four basic types of bone cells; osteoclasts, osteoblast, bone lining cells and osteocytes. Mbalaviele et al (1995) showed that E-cadherin was expressed by osteoclasts, but no expression of N-cadherin was detected in these cells (). In osteoblasts, Ferrari et al (2000) demonstrated that N-cadherin was expressed and this was increased during osteoblastogenesis. This study suggested a role for in the late stage of osteoblast differentiation (). Kawaguchi et al (2001) also showed that N-cadherin was expressed by osteoblasts and this expression was increased during osteoblastogenesis (). Marie (2002) demonstrated that the marked increases in
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