FDA Duloxetine 20-40 Yes 8 T8 1139 - - No 125 80 Yes Deuloxetine Placebo 777 - - 47 23 study (Application number 21-427) FDA Escitalopram 10-20 Yes 8 T8 715 - - No 64 23 Yes Escitalopram Placebo 527 - - 24 12 study I (Application number 21-323) FDA Escitalopram 10 Yes 8 T8 310 - - No 22 12 Yes Escitalopram Escitalopram 20 125 - - 17 11 trial I table 2 (Application Placebo 311 - - 12 3 number 21-323) FDA Citalopram 20 Yes 8 T8 125 62.4 40 ± 11.5 No 14 - Yes Escitalopram Escitalopram 10 124 70.6 40.6±12.3 12 - study II Escitalopram 20 128 67.2 39.6± 12.1 17 - Placebo 127 59.0 40.3± 10.6 4 - FDA Fluvoxamine 20-80 Yes 8 T8 1728 - - No 276 225 Yes Fluvoxamine Placebo 975 - - 88 58 study FDA Mirtazapine 21-32 Yes 8 T8 453 - - No - 245 Yes Mirtazapine Placebo 361 - - - 65 study (ID: 3210056) FDA Paroxetine 20-50 Yes 8 T8 421 - - No 55 97 Yes Paroxetine Placebo 421 - - 25 38 study I (Reference ID: 3231319)
FDA Deuloxetine study (Application number 21-427) Duloxetine Placebo 20-40 Yes 8 T8 1139 777 - - - - No 125 47 80 23 Yes FDA Escitalopram study I (Application number 21-323) Escitalopram Placebo 10-20 Yes 8 T8 715 527 - - - - No 64 24 23 12 Yes FDA Escitalopram I table 2 (Application number 21-323) Escitalopram Escitalopram Placebo 10 20 Yes 8 T8 310 125 311 - - - - - - No 22 17 12 12 11 3 Yes FDA Escitalopram study II Citalopram Escitalopram Escitalopram Placebo 20 10 20 Yes 8 T8 125 124 128 127 62.4 70.6 67.2 59.0 40 ± 11.5 40.6±12.3 39.6± 12.1 40.3± 10.6 No 14 12 17 4 - - - - Yes FDA Fluvoxamine study Fluvoxamine Placebo 20-80 Yes 8 T8 1728 975 - - - - No 276 88 225 58 Yes FDA Mirtazapine study (ID: 3210056) Mirtazapine Placebo 21-32 Yes 8 T8 453 361 - - - - No - - 245 65 Yes FDA Paroxetine study I (Reference ID: 3231319) Paroxetine Placebo 20-50 Yes 8 T8 421 421 - - - - No 55 25 97 38 Yes trial
JCP_00_00_2015_03_31_SERRETTI_JCP14173_SDC1.docx