Appendix Table : Results of sensitivity analysis of network meta-analysis using alternate cut points for the dosing of mesalamine and budesonide for the induction of remission of patients disease with Crohn’s Intervention COMPARATOR Odds ratio (95% Credible interval)* Probability intervention superior to comparator Placebo <2g 2-4g >4g 3 or 6mg 9mg 15 or 18mg Sulfasalazine Mesalamine Mesalamine Mesalamine Budesonide Budesonide Budesonide <2g Mesalamine 1.22 - (0.46, 3.13) 66% 2-4g Mesalamine 2.01* 1.65 - (1.24, 3.38) (0.69, 4.13) >99% 88% 1.84 1.52 0.92 - >4g Mesalamine (0.75, 3.99) (0.41, 4.91) (0.34, 2.09) 92% 75% 42% 3 or 6mg 1.53 1.26 0.76 0.83 - (0.69, 3.28) (0.37, 4.07) (0.31, 1.78) (0.31, 2.42) Budesonide 86% 65% 26% 36% 9mg Budesonide 3.03* 2.49 1.51 1.64 1.97 - (1.85, 4.73) (0.89, 6.85) (0.83, 2.54) (0.82, 3.60) (0.95, 4.12) 96% 92% 93% 97% >99% 15 or 18mg 3.36* 2.76 1.66 1.83 2.18* 1.11 - Budesonide (1.63, 6.83) (0.87, 9.01) (0.73, 3.73) (0.72, 5.22) (1.02, 4.80) (0.58, 2.17) >99% 96% 89% 90% 98% 63% Sulfasalazine 1.53 1.26 0.76 0.83 1.00 0.50 0.46 -
Appendix Table : Results of sensitivity analysis of network meta-analysis using alternate cut points for the dosing of mesalamine and budesonide for the induction of remission of patients with Crohn’s disease Intervention COMPARATOR Odds ratio (95% Credible interval)* Probability intervention superior to comparator Placebo <2g Mesalamine 2-4g Mesalamine >4g Mesalamine 3 or 6mg Budesonide 9mg Budesonide 15 or 18mg Budesonide Sulfasalazine <2g Mesalamine 1.22 (0.46, 3.13) 66% - 2-4g Mesalamine 2.01* (1.24, 3.38) >99% 1.65 (0.69, 4.13) 88% - >4g Mesalamine 1.84 (0.75, 3.99) 92% 1.52 (0.41, 4.91) 75% 0.92 (0.34, 2.09) 42% - 3 or 6mg Budesonide 1.53 (0.69, 3.28) 86% 1.26 (0.37, 4.07) 65% 0.76 (0.31, 1.78) 26% 0.83 (0.31, 2.42) 36% - 9mg Budesonide 3.03* (1.85, 4.73) >99% 2.49 (0.89, 6.85) 96% 1.51 (0.83, 2.54) 92% 1.64 (0.82, 3.60) 93% 1.97 (0.95, 4.12) 97% - 15 or 18mg Budesonide 3.36* (1.63, 6.83) >99% 2.76 (0.87, 9.01) 96% 1.66 (0.73, 3.73) 89% 1.83 (0.72, 5.22) 90% 2.18* (1.02, 4.80) 98% 1.11 (0.58, 2.17) 63% - Sulfasalazine 1.53 1.26 0.76 0.83 1.00 0.50 0.46 -
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