Cyclosporine Calcineurin Solid organ Inhibit T cell Infection, malignancy, HT, inhibitor transplant, GVHD, activation nephrotoxic, liver toxic, seizure, KD, lupus encephalopathy, BM suppression, nephritis, nephrotic TMA, gum hyperplasia, syndrome hypertrichosis, GI upset Daclizumab Anti-IL-2 receptor Multiple sclerosis Liver toxic, autoimmune hepatitis, (anti-CD25) immune-mediated disorder (skin, antibody LN, colitis), seizure, anaemia, lymphopenia, allergic reaction, infection, fever Eculizumab anti-C5 PNH, atypical Binds to C5 Major: headache, monocloncal HUS, thrombotic preventing thrombocytopenia, leukopenia, antibody microangiopathy haemolysis and haemolysis, GE complaints, post-BMT coagulation infections, fever & chills, asthenia, oedema, oral herpes, URT infections, anaphylaxis, skin reactions, myalgia Etanercept Anti-TNF JIA, idiopathic Infection, malignancy, rash, allergic pneumonia reaction, injection site reaction, syndrome, KD, heart failure, CNS demyelination FMF Infliximab Anti-TNF JIA, KD, IBD Infection, malignancy, cytopenia, rash, heart failure, hepatitis, CNS demyelination, infusion reaction Mycophenolate Mycophenolate Solid organ hyperlipidaemia, cytopenia, GI mofetil mofetil is an ester transplant, lupus upset, infection, malignancy prodrug that is nephritis hydrolyzed to the active immune suppressor mycophenolic acid (MPA). MPA inhibits the activity of inosine monophosphate dehydrogenase, a key enzyme in the de novo pathway of guanosine nucleotide synthesis in B and T that slows their proliferative response
Cyclosporine Calcineurin inhibitor Solid organ transplant, GVHD, KD, lupus nephritis, nephrotic syndrome Inhibit T cell activation Infection, malignancy, HT, nephrotoxic, liver toxic, seizure, encephalopathy, BM suppression, TMA, gum hyperplasia, hypertrichosis, GI upset Daclizumab Anti-IL-2 receptor (anti-CD25) antibody Multiple sclerosis Liver toxic, autoimmune hepatitis, immune-mediated disorder (skin, LN, colitis), seizure, anaemia, lymphopenia, allergic reaction, infection, fever Eculizumab anti-C5 monocloncal antibody PNH, atypical HUS, thrombotic microangiopathy post-BMT Binds to C5 preventing haemolysis and coagulation Major: headache, thrombocytopenia, leukopenia, haemolysis, GE complaints, infections, fever & chills, asthenia, oedema, oral herpes, URT infections, anaphylaxis, skin reactions, myalgia Etanercept Anti-TNF JIA, idiopathic pneumonia syndrome, KD, FMF Infection, malignancy, rash, allergic reaction, injection site reaction, heart failure, CNS demyelination Infliximab Anti-TNF JIA, KD, IBD Infection, malignancy, cytopenia, rash, heart failure, hepatitis, CNS demyelination, infusion reaction Mycophenolate mofetil Mycophenolate mofetil is an ester prodrug that is hydrolyzed to the active immune suppressor mycophenolic acid (MPA). MPA inhibits the activity of inosine monophosphate dehydrogenase, a key enzyme in the de novo pathway of guanosine nucleotide synthesis in B and T that slows their proliferative response Solid organ transplant, lupus nephritis hyperlipidaemia, cytopenia, GI upset, infection, malignancy
PICU%20Guidelines%20Nov%2015th%202017.docx