IL-6 Released in response to IL-1; Macrophages, mast cells, induces fever; enhances release of keratinocytes, acute-phase reactants by the liver; lymphocytes. inhibits ECM breakdown during mediator) proliferation. IL-7 Lymphocyte maturation Stromal cells of red bone marrow and thymus IL-8 Enhances neutrophil adherence, Macrophages, mast cells, chemotaxis and granule release; keratinocytes, enhances epithelialisation. lymphocytes. IL-9 Stimulate mast cells T lymphocytes IL-10 Downregulates cytokine expression Mesenchymal stem cell. in latter stages (anti-inflammatory). (Cross and Mustoe, 2003; Stratford 2006) et al., Colony Stimulating Factor (CSF) Colony Stimulating Factor (CSF) is a member of a group of cytokines that stimulate wound-healing. Macrophages secrete CSF-1, an autocrine mediator, in order to in an act of The macrophage ‘reproduce’ itself ‘self-preservation’. releases granulocyte-macrophage CSF, which has chemotactic, as well as cellular proliferation and activation abilities (Stratford 2006). et al., Interferon (IFN) The interferon (IFN) group is made up of three subtypes; IFN-, IFN- and Each group is named according to their capability to with viral ‘interfere’
IL-6 Released in response to IL-1; induces fever; enhances release of acute-phase reactants by the liver; inhibits ECM breakdown during proliferation. Macrophages, mast cells, keratinocytes, lymphocytes. mediator) IL-7 Lymphocyte maturation Stromal cells of red bone marrow and thymus IL-8 Enhances neutrophil adherence, chemotaxis and granule release; enhances epithelialisation. Macrophages, mast cells, keratinocytes, lymphocytes. IL-9 Stimulate mast cells T lymphocytes IL-10 Downregulates cytokine expression in latter stages (anti-inflammatory). Mesenchymal stem cell. (Cross and Mustoe, 2003; Stratford et al., 2006) Colony Stimulating Factor (CSF) Colony Stimulating Factor (CSF) is a member of a group of cytokines that stimulate wound-healing. Macrophages secrete CSF-1, an autocrine mediator, in order to ‘reproduce’ itself in an act of ‘self-preservation’. The macrophage releases granulocyte-macrophage CSF, which has chemotactic, as well as cellular proliferation and activation abilities (Stratford et al., 2006). Interferon (IFN) The interferon (IFN) group is made up of three subtypes; IFN-, IFN- and Each group is named according to their capability to ‘interfere’ with viral
PhDthesis_ANDREW_SLOAN.docx