(VV4. Questions relating to the nature of recombinant or synthetic nucleic acid sequences transduced by the virus, continued): (a) (b) (c) (d) (e) (f) (g) Insert Nucleic acid Species of Expression Insert name Involved in cell control? Pathogenic type origin (Promoter) Potentially adverse effects? conversion? Expression Gene symbol, genomic, Insert name, then list potentially proliferation, cell survival ex. ex: preferably in cDNA, adverse effects (ex: oncogenic alphabetic order microRNA, potential, toxic, pro-inflammatory) etc. Insert name Insert Nucleic acid Species of Expression Involved in cell control? Pathogenic type origin (Promoter) Potentially adverse effects? conversion? Antisense or Knockout Gene symbol, shRNA, or, species Insert name, then list potentially proliferation, cell survival ex: ex: preferably in siRNA, sgRNA homology adverse effects (ex: oncogenic alphabetic order for CRISPR, for potential, toxic, pro-inflammatory) etc. sgRNA VV Form Revision Date: 12/14/2016
(VV4. Questions relating to the nature of recombinant or synthetic nucleic acid sequences transduced by the virus, continued): (a) (b) (c) (d) (e) (f) (g) Insert Nucleic acid type Species of origin Expression (Promoter) Insert name Potentially adverse effects? Involved in cell control? Pathogenic conversion? Expression Gene symbol, preferably in alphabetic order ex. genomic, cDNA, microRNA, etc. Insert name, then list potentially adverse effects (ex: oncogenic potential, toxic, pro-inflammatory) ex: proliferation, cell survival Insert Nucleic acid type Species of origin Expression (Promoter) Insert name Potentially adverse effects? Involved in cell control? Pathogenic conversion? Antisense or Knockout Gene symbol, preferably in alphabetic order ex: shRNA, siRNA, sgRNA for CRISPR, etc. or, species homology for sgRNA Insert name, then list potentially adverse effects (ex: oncogenic potential, toxic, pro-inflammatory) ex: proliferation, cell survival VV Form Revision Date: 12/14/2016
IBCregistrationnewPIs.docx