1.1 Amphetamines (speed) Study ref Study LoE Sample Aim/methods Findings Comments design size SLR IV 10 cohort Aim: to systematically review the Significant increases in unadjusted risks of () studies relationship between amphetamine preterm birth (OR 4.11; 95%CI, 3.05 to 5.55), exposure in pregnancy and birth low birthweight (OR 3.97; 95%CI, 2.45 to 6.43), outcomes. and small for gestational age (OR 5.79; 95%CI 1.39 to 24.06) were identified among women Methods: Electronic databases were exposed to amphetamines in pregnancy. searched to identify relevant studies. Data Mean birthweight was significantly lower from included studies were extracted by 2 among amphetamine-exposed pregnancies reviewers. Summary odds ratio (OR) and (MD g; 95% CI, to -74 g). Two studies –279 –485 confidence intervals (Cis) were calculated provided adjusted estimates on different using the random effects model. outcomes, and their results were consistent with the findings from the unadjusted data. 1.2 Opioids ref Study LoE Sample Aim/methods Findings Comments design size
1.1 Amphetamines (speed) Study ref Study design LoE Sample size Aim/methods Findings Comments () SLR IV 10 cohort studies Aim: to systematically review the relationship between amphetamine exposure in pregnancy and birth outcomes. Methods: Electronic databases were searched to identify relevant studies. Data from included studies were extracted by 2 reviewers. Summary odds ratio (OR) and confidence intervals (Cis) were calculated using the random effects model. Significant increases in unadjusted risks of preterm birth (OR 4.11; 95%CI, 3.05 to 5.55), low birthweight (OR 3.97; 95%CI, 2.45 to 6.43), and small for gestational age (OR 5.79; 95%CI 1.39 to 24.06) were identified among women exposed to amphetamines in pregnancy. Mean birthweight was significantly lower among amphetamine-exposed pregnancies (MD –279 g; 95% CI, –485 to -74 g). Two studies provided adjusted estimates on different outcomes, and their results were consistent with the findings from the unadjusted data. 1.2 Opioids ref Study design LoE Sample size Aim/methods Findings Comments
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