APPENDIX A: SUPPLEMENTAL ON THE LITERATURE Reference Objective Population Study Design Disease Reinfection Limitations Incidence or Results Prevalence Mosure et al. Determine rates and 15-19 year old Retrospective Prevalence = 22% 18.0% Majority did not [12] predictors of females; cohort. make second visit; chlamydia Family Medical history of STI not in reinfection planning database analysis; could have clinics in review. been tested at region planning clinics Oh et al. [13] Determine incidence Sexually Prospective Overall incidence = 25.3% Intervals between and risk of active females cohort. 15% Gonorrhea = Overall; rescreening not gonorrhea/chlamydia 11-19 years Analysis on 11.6% Chlamydia 40% uniform; high reinfection among old; subjects with = 23.2% Gonorrha; attrition rates; small adolescent females Adolescent at 2 18% sample size; not clinics of visits Chlamydia generalizable; does Dvision of not include history of Adolescent STDs in analysis Medicine Southeastern U.S. Michelson et al. Describe Lab confirmed Retrosective Incidence = 563 13.0% Cases reported [14] demographics, risk, chlamydia cohort. infections per dependent on site of and geographical tests sent to Review of 100,000 diagnosis; excluded distribution of STEP County test results. asymptomatic males; chlamydia infections Health excluded those who Department did not seek treatment Xu et al. [15] Use Women 10-44 Retrospective N/A 20.2% may have registry to analyze years old; cohort. moved out of state; frequency and Initial positive Medical non-universal predictors of repeat test during database screening; chlamydial infection study period review. reporting in women
APPENDIX A: SUPPLEMENTAL ON THE LITERATURE Reference Objective Population Study Design Disease Incidence or Prevalence Reinfection Results Limitations Mosure et al. [12] Determine rates and predictors of chlamydia reinfection 15-19 year old females; Family planning clinics in region Retrospective cohort. Medical database review. Prevalence = 22% 18.0% Majority did not make second visit; history of STI not in analysis; could have been tested at planning clinics Oh et al. [13] Determine incidence and risk of gonorrhea/chlamydia reinfection among adolescent females Sexually active females 11-19 years old; Adolescent clinics of Dvision of Adolescent Medicine Southeastern U.S. Prospective cohort. Analysis on subjects with at 2 visits Overall incidence = 15% Gonorrhea = 11.6% Chlamydia = 23.2% 25.3% Overall; 40% Gonorrha; 18% Chlamydia Intervals between rescreening not uniform; high attrition rates; small sample size; not generalizable; does not include history of STDs in analysis Michelson et al. [14] Describe demographics, risk, and geographical distribution of chlamydia infections Lab confirmed chlamydia tests sent to STEP County Health Department Retrosective cohort. Review of test results. Incidence = 563 infections per 100,000 13.0% Cases reported dependent on site of diagnosis; excluded asymptomatic males; excluded those who did not seek treatment Xu et al. [15] Use registry to analyze frequency and predictors of repeat chlamydial infection in women Women 10-44 years old; Initial positive test during study period Retrospective cohort. Medical database review. N/A 20.2% may have moved out of state; non-universal screening; reporting
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