period) and provide the citations. Risk of bias within 19 Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). 9 studies Results of individual 20 For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each 9-11 studies intervention group (b) effect estimates and confidence intervals, ideally with a forest plot. Synthesis of results 21 Present results of each meta-analysis done, including confidence intervals and measures of consistency. NA Risk of bias across 22 Present results of any assessment of risk of bias across studies (see Item 15). 9 studies Additional analysis 23 Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item NA 16]). DISCUSSION Summary of evidence 24 Summarize the main findings including the strength of evidence for each main outcome; consider their 12-13 relevance to key groups (e.g., healthcare providers, users, and policy makers). Limitations 25 Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete 14 retrieval of identified research, reporting bias). Conclusions 26 Provide a general interpretation of the results in the context of other evidence, and implications for future 14 research. FUNDING Funding 27 Describe sources of funding for the systematic review and other support (e.g., supply of data); role of 4 funders for the systematic review.
period) and provide the citations. Risk of bias within studies 19 Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). 9 Results of individual studies 20 For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each intervention group (b) effect estimates and confidence intervals, ideally with a forest plot. 9-11 Synthesis of results 21 Present results of each meta-analysis done, including confidence intervals and measures of consistency. NA Risk of bias across studies 22 Present results of any assessment of risk of bias across studies (see Item 15). 9 Additional analysis 23 Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item 16]). NA DISCUSSION Summary of evidence 24 Summarize the main findings including the strength of evidence for each main outcome; consider their relevance to key groups (e.g., healthcare providers, users, and policy makers). 12-13 Limitations 25 Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval of identified research, reporting bias). 14 Conclusions 26 Provide a general interpretation of the results in the context of other evidence, and implications for future research. 14 FUNDING Funding 27 Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders for the systematic review. 4
icmo_a_1281109_sm0750.docx