Lysis may be another end result of complement cold autoimmune hemolytic anemia activation, such as in what? What usually manifests itself in increased Hereditary deficiency of any complement susceptibility to infection and delayed clearance protein of immune complexes? Most of these complement protein conditions 0.03% are inherited on an autosomal recessive gene, and they are quite rare, occurring in what percent of the general population? A second deficiency that occurs with some 3 5% – frequency is that of mannose-binding lectin, found in what percent of the population? Lack of what has been associated with MBL pneumonia, sepsis, and meningococcal disease in infants? The most serious deficiency is of what, because C3 it is the key mediator in all pathways? Individuals with paroxysmal nocturnal DAF hemoglobinuria (PNH) have red cells that are deficient in what? Some studies indicate that a DAF deficiency is CD59 (MIRL) associated with a lack of what? A deficiency in the what of the DAF molecule glycophospholipid anchor prevents its insertion into the cell membrane? What prevents insertion of C9 into the cell CD59 membrane by binding to the C5b678 complex, thus inhibiting formation of transmembrane channels? Recurrent attacks of angioedema that affect the hereditary angioedema extremities, skin, gastrointestinal tract, and other mucosal surfaces are characteristic of? What results in excess cleavage of C4 and C2, deficiency or lack of keeping the classical pathway going and creating kinin-related proteins that increase vascular permeability? What are the methods most frequently used to radial immunodiffusion (RID) and assay individual complement components? nephelometry Assays are available for Clq, C4, C3, C5, factor whether the molecules are functionally active B, factor H, factor I, C1 inhibitor, and C3a, C4a, and C5a, but what can they not tell about the factors? What is most commonly used to measure lysis, The hemolytic titration (CH50) assay the end point of complement activation, as a functional test of complement activity? What test measures the amount of patient serum The hemolytic titration (CH50) assay required to lyse 50 percent of a standardized
Lysis may be another end result of complement activation, such as in what? cold autoimmune hemolytic anemia What usually manifests itself in increased susceptibility to infection and delayed clearance of immune complexes? Hereditary deficiency of any complement protein Most of these complement protein conditions are inherited on an autosomal recessive gene, and they are quite rare, occurring in what percent of the general population? 0.03% A second deficiency that occurs with some frequency is that of mannose-binding lectin, found in what percent of the population? 3 – 5% Lack of what has been associated with pneumonia, sepsis, and meningococcal disease in infants? MBL The most serious deficiency is of what, because it is the key mediator in all pathways? C3 Individuals with paroxysmal nocturnal hemoglobinuria (PNH) have red cells that are deficient in what? DAF Some studies indicate that a DAF deficiency is associated with a lack of what? CD59 (MIRL) A deficiency in the what of the DAF molecule prevents its insertion into the cell membrane? glycophospholipid anchor What prevents insertion of C9 into the cell membrane by binding to the C5b678 complex, thus inhibiting formation of transmembrane channels? CD59 Recurrent attacks of angioedema that affect the extremities, skin, gastrointestinal tract, and other mucosal surfaces are characteristic of? hereditary angioedema What results in excess cleavage of C4 and C2, keeping the classical pathway going and creating kinin-related proteins that increase vascular permeability? deficiency or lack of What are the methods most frequently used to assay individual complement components? radial immunodiffusion (RID) and nephelometry Assays are available for Clq, C4, C3, C5, factor B, factor H, factor I, C1 inhibitor, and C3a, C4a, and C5a, but what can they not tell about the factors? whether the molecules are functionally active What is most commonly used to measure lysis, the end point of complement activation, as a functional test of complement activity? The hemolytic titration (CH50) assay What test measures the amount of patient serum required to lyse 50 percent of a standardized The hemolytic titration (CH50) assay
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