T cells play a role in what immunity? Cell-mediated immunity and produce sensitized lymphocytes that secrete cytokines B cells are derived from what precursor? Common lymphoid precursor (CLP) Common lymphoid precursor differentiate into B cell progenitor cell what? Early lymphocyte progenitors can becomes T-cell, B-cell NK cells, or dendritic cells what? What are some example of differentiation of B Pro- B cells cell? Pre-B cells Immature B cells Mature B cells Activated B cells Plasma cells Memory cells The earliest B-cell precursor can be recognized CD45R by the presence of a surface molecule called? What so important about antigen-independent Process that prepares them for role in phase? antibody production and restricts the types of antigen to which the cell can respond. How does influence of growth factors and This causes rearrangement of genes to occur cytokines effect the differentiation of B cells? and codes for the heavy and light chains of an antibody molecule. After the rearrangement of genes occurs what is B lymphocyte programmed to produce a unique the outcome? antibody molecule, consisting of two identical light chains and two identical heavy chains. When B lymphocytes produce two identical Pro-B cell light chains and two identical heavy chains, what is this process called? What are some example of markers that exist on CD19, CD45R, CD43, CD24, and c-Kit surface of pro-B cells? In order for pro-B cells to differentiate into Successful rearrangement of heavy-chains cell successfully what must occur? genes. What cell interact with pro-B cells to secrete Stromal cells cytokines, hormones, chemokines, and adhesion molecules? What does the pre-B stage begins? When synthesis of the chain part of the antibody molecule occurs pre-B cells is complete which marker CD43 marker as well as c-Kit and TdT surface marker does it lose? Where does Mu chains accumulate? In the cytoplasm Which combination of chain forms the pre-B Combination of two heavy chains and two cell receptors? surrogate light chains plus two very short (Ig-α and Ig-β) The pre-B cell receptor adheres to what part of Bone marrow stromal cell membranes and the body? transmits a signal to prevent rearrangement of any heavy-chains genes
T cells play a role in what immunity? Cell-mediated immunity and produce sensitized lymphocytes that secrete cytokines B cells are derived from what precursor? Common lymphoid precursor (CLP) Common lymphoid precursor differentiate into what? B cell progenitor cell Early lymphocyte progenitors can becomes what? T-cell, B-cell NK cells, or dendritic cells What are some example of differentiation of B cell? Pro- B cells Pre-B cells Immature B cells Mature B cells Activated B cells Plasma cells Memory cells The earliest B-cell precursor can be recognized by the presence of a surface molecule called? CD45R What so important about antigen-independent phase? Process that prepares them for role in antibody production and restricts the types of antigen to which the cell can respond. How does influence of growth factors and cytokines effect the differentiation of B cells? This causes rearrangement of genes to occur and codes for the heavy and light chains of an antibody molecule. After the rearrangement of genes occurs what is the outcome? B lymphocyte programmed to produce a unique antibody molecule, consisting of two identical light chains and two identical heavy chains. When B lymphocytes produce two identical light chains and two identical heavy chains, what is this process called? Pro-B cell What are some example of markers that exist on surface of pro-B cells? CD19, CD45R, CD43, CD24, and c-Kit In order for pro-B cells to differentiate into cell successfully what must occur? Successful rearrangement of heavy-chains genes. What cell interact with pro-B cells to secrete cytokines, hormones, chemokines, and adhesion molecules? Stromal cells What does the pre-B stage begins? When synthesis of the chain part of the antibody molecule occurs pre-B cells is complete which marker surface marker does it lose? CD43 marker as well as c-Kit and TdT Where does Mu chains accumulate? In the cytoplasm Which combination of chain forms the pre-B cell receptors? Combination of two heavy chains and two surrogate light chains plus two very short (Ig-α and Ig-β) The pre-B cell receptor adheres to what part of the body? Bone marrow stromal cell membranes and transmits a signal to prevent rearrangement of any heavy-chains genes
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