Significantly reduced incidences of hyperprolactinaemia and weight gain than other antipsychotics TUTORIAL: Loss of SNc function leads to pathological rise in Ach signaling Anti ACh medications can therefore be used in parkinsons High ACh explains the autonomic dysfunction effects Tyramine is a breakdown product of tyrosine Cocaine has local anaesthetic properties Ethanol can induce a pseudo-Cushing’s syndrome Asian races possess genetic variations in the enzyme alcohol dehydrogenase associated with alcoholism Asian races possess genetic variations in the enzyme aldehyde dehydrogenase associated with alcohol intolerance [easter egg] I bet you think you are so big and clever using CTRL + F “easter egg” to find this. Well $*%& you! Or was it the squiggly red lines that gave away my hiding place? [/easter egg] 09/05/14: Opioids: Dr Chris John Los (from booklet): Learning objectives 1. Define the terms opiate and opioid; identify the importance of opiates and opioids in the clinical control of severe pain. 2. List the principal subtypes of opioid receptor and identify their endogenous ligands 3. Identify the signalling mechanisms used by opioid receptors. 4. Identify the main central nervous pathways concerned with pain transmission/perception. Identify sites within these pathways where opiates/opioids modify transmission. 5. Explain how opiates influence physiological function (e.g. respiration) and identify which of these actions may be advantageous clinically and which may cause unwanted effects.
Significantly reduced incidences of hyperprolactinaemia and weight gain than other antipsychotics TUTORIAL: Loss of SNc function leads to pathological rise in Ach signaling Anti ACh medications can therefore be used in parkinsons High ACh explains the autonomic dysfunction effects Tyramine is a breakdown product of tyrosine Cocaine has local anaesthetic properties Ethanol can induce a pseudo-Cushing’s syndrome Asian races possess genetic variations in the enzyme alcohol dehydrogenase associated with alcoholism Asian races possess genetic variations in the enzyme aldehyde dehydrogenase associated with alcohol intolerance [easter egg] I bet you think you are so big and clever using CTRL + F “easter egg” to find this. Well $*%& you! Or was it the squiggly red lines that gave away my hiding place? [/easter egg] 09/05/14: Opioids: Dr Chris John Los (from booklet): Learning objectives 1. Define the terms opiate and opioid; identify the importance of opiates and opioids in the clinical control of severe pain. 2. List the principal subtypes of opioid receptor and identify their endogenous ligands 3. Identify the signalling mechanisms used by opioid receptors. 4. Identify the main central nervous pathways concerned with pain transmission/perception. Identify sites within these pathways where opiates/opioids modify transmission. 5. Explain how opiates influence physiological function (e.g. respiration) and identify which of these actions may be advantageous clinically and which may cause unwanted effects.
Pharmacology-II-notes-BETA.docx