C6 DEHP Rat: Rabbit: Rat: ME ME Insufficient negative Non-genotoxic Rat: F344 rat: 140: Fertility. 14: testes wt, ↓ ↓ 30600 24750 >10.62 data LOAEL = 146.6; LOAEL = 146.6; seminiferous NOAEL = 28.9; NOAEL = 28.9; tubule atrophy. – >40000 Liver, kidney. Adenomas, carcinomas, MCL. LOAEL = 37.6; Sprague-Dawley NOAEL= 3.7; Testes. rat: Adenomas, carcinomas; benign Leydig cell tumours. Mouse: LOAEL = 292; NOAEL = 98; Adenomas and carcinomas. Syrian golden hamster: C7 DIOP Rat: Rabbit: ME negative Unlikely to be Insufficient data Negative in vitro. >22000 >3160 genotoxic Inhalation: negative. C8 DnOP Rat: Guinea ME ME Insufficient negative Non-genotoxic Rat: Rat: Insufficient data. NE NE 53700 pig: data LOAEL = 350; 75 NOAEL = 37; bw Liver, thyroid C7-9 Di-C7-9 Rat: negative negative negative Unlikely to be Rat: NE > 1000 1000: PE >15000 genotoxic LOAEL = 120 Skeletal ↑ NOAEL = 60 variations – >20000 Liver, testes, blood, (lumbar ribs). kidney C8, C9 DINP Rat: Rabbit: Rat, 4h: ME ME negative Non-genotoxic Rat: Rat: Mouse: Rat: LOAEL = 358-442 >10000 >3160 >4.4 LOAEL = 358-442 (m- 742 (m): 159-395 (m-f): (CAS (CAS f); (m-f); Testes weight. Pup weight at ↓ ↓ 68515- 68515- NOAEL = 88-108 (m- NOAEL = 88-108 (m- weaning. 48-0); 48-0) f); f); Rat: >40000 Liver, kidney. MCL 966: ↑ (CAS live birth and ↓ 28553- Mouse: survival indices 12-0) LOAEL = 335 (f) &
C6 DEHP Rat: 30600 – >40000 Rabbit: 24750 Rat: >10.62 ME ME Insufficient data negative Non-genotoxic Rat: LOAEL = 146.6; NOAEL = 28.9; Liver, kidney. LOAEL = 37.6; NOAEL= 3.7; Testes. F344 rat: LOAEL = 146.6; NOAEL = 28.9; Adenomas, carcinomas, MCL. Sprague-Dawley rat: Adenomas, carcinomas; benign Leydig cell tumours. Mouse: LOAEL = 292; NOAEL = 98; Adenomas and carcinomas. Syrian golden hamster: Inhalation: negative. 140: ↓ Fertility. 14: ↓ testes wt, seminiferous tubule atrophy. C7 DIOP Rat: >22000 Rabbit: >3160 ME negative Unlikely to be genotoxic Insufficient data Negative in vitro. C8 DnOP Rat: 53700 bw Guinea pig: 75 ME ME Insufficient data negative Non-genotoxic Rat: LOAEL = 350; NOAEL = 37; Liver, thyroid Rat: Insufficient data. NE NE C7-9 Di-C7-9 PE Rat: >15000 – >20000 negative negative negative Unlikely to be genotoxic Rat: LOAEL = 120 NOAEL = 60 Liver, testes, blood, kidney NE > 1000 1000: ↑ Skeletal variations (lumbar ribs). C8, C9 DINP Rat: Rabbit: Rat, 4h: ME ME negative Non-genotoxic Rat: Rat: Mouse: Rat: >10000 >3160 >4.4 LOAEL = 358-442 (m- LOAEL = 358-442 742 (m): 159-395 (m-f): (CAS (CAS f); (m-f); ↓ Testes weight. ↓ Pup weight at 68515- 68515- NOAEL = 88-108 (m- NOAEL = 88-108 (m- weaning. 48-0); 48-0) f); f); Rat: >40000 Liver, kidney. ↑ MCL 966: (CAS ↓ live birth and 28553- Mouse: survival indices 12-0) LOAEL = 335 (f) &
Phthalates-hazard-compendium.docx