In N-methylpelletierene isolated from the control experiment atoms labelled j, k and l in the structure shown have 13C NMR chemical shifts of 31.0, 207.8 and 47.1 respectively. Each of these peaks is a singlet. These peaks also appear in the spectra of N-methylpelletierene isolated in experiments 1 and 2, however there are also the following additional peaks: Experiment 1 Experiment 2 Coupling Coupling 13C shift 13C shift Multiplicity constant Multiplicity constant (ppm) (ppm) (Hz) (Hz) 31.0 doublet 40.4 ± 1.8 31.0 doublet of 39.8 ± 1.8 doublets 14.4 ± 1.8 207.8 doublet 39.5 ± 1.8 47.1 doublet of 39.4 ± 1.8 doublets 13.7 ± 1.8 208.7 doublet of 39.4 ± 1.8 doublets 39.5 ± 1.8 Which route does the biosynthesis of pelletierene follow? The synthesis of methadone Methadone Methadone is an analgesic drug with a similar activity to morphine and is used in treating heroin addicts. It may be prepared as its hydrochloride salt by the following multi-stage synthesis: Intermediate C is a chloride salt and may be prepared by treating two isomeric compounds with SOCl2 and then heating up the reaction mixture:
In N-methylpelletierene isolated from the control experiment atoms labelled j, k and l in the structure shown have 13C NMR chemical shifts of 31.0, 207.8 and 47.1 respectively. Each of these peaks is a singlet. These peaks also appear in the spectra of N-methylpelletierene isolated in experiments 1 and 2, however there are also the following additional peaks: Experiment 1 Experiment 2 13C shift (ppm) Multiplicity Coupling constant (Hz) 13C shift (ppm) Multiplicity Coupling constant (Hz) 31.0 doublet 40.4 ± 1.8 31.0 doublet of doublets 39.8 ± 1.8 14.4 ± 1.8 207.8 doublet 39.5 ± 1.8 47.1 doublet of doublets 39.4 ± 1.8 13.7 ± 1.8 208.7 doublet of doublets 39.4 ± 1.8 39.5 ± 1.8 Which route does the biosynthesis of pelletierene follow? The synthesis of methadone Methadone Methadone is an analgesic drug with a similar activity to morphine and is used in treating heroin addicts. It may be prepared as its hydrochloride salt by the following multi-stage synthesis: Intermediate C is a chloride salt and may be prepared by treating two isomeric compounds with SOCl2 and then heating up the reaction mixture:
IChO41UK2009PPq.docx