1mo-18yr: 25mg/kg 8-hourly (max 1g per dose) Cefalexin <7days: 50mg/kg 12-hourly 7-21days: 50mg/kg 8-hourly 21days-18yr: 50mg/kg 8-hourly (6 hourly for meningitis) (max. 12g per day) Neonatal dose banding option for >0.5kg babies with early-onset sepsis (if over 7 days of age change to 50mg/kg 8-hourly): Cefotaxime CF only: Cefoxitin >1mo: 40mg/kg 6-hourly (max 3g/dose) <7days: 50mg/kg 24-hourly CF: (nebulised 7-20days: 50mg/kg 12-hourly using iv prep) 21days–18yr: 50mg/kg 8-hourly (max. 6g daily 1g 12-hourly Ceftazidime except CF with pseudomonas chest infection when max 9g daily (if over 12yr up to 12g daily may be considered.) Can use ceftriaxone age <1 month if weeks ≥37 gestation & no contraindications (see below) <15 days: 50 mg/kg once daily Ceftriaxone days: 80mg/kg once daily (max 4g daily) ≥15 2nd dose of ceftriaxone can be given between 12-24 hours following the first dose to facilitate ambulation . –
Cefalexin 1mo-18yr: 25mg/kg 8-hourly (max 1g per dose) Cefotaxime <7days: 50mg/kg 12-hourly 7-21days: 50mg/kg 8-hourly 21days-18yr: 50mg/kg 8-hourly (6 hourly for meningitis) (max. 12g per day) Neonatal dose banding option for >0.5kg babies with early-onset sepsis (if over 7 days of age change to 50mg/kg 8-hourly): Cefoxitin CF only: >1mo: 40mg/kg 6-hourly (max 3g/dose) Ceftazidime <7days: 50mg/kg 24-hourly 7-20days: 50mg/kg 12-hourly 21days–18yr: 50mg/kg 8-hourly (max. 6g daily except CF with pseudomonas chest infection when max 9g daily (if over 12yr up to 12g daily may be considered.) CF: (nebulised using iv prep) 1g 12-hourly Ceftriaxone Can use ceftriaxone age <1 month if ≥37 weeks gestation & no contraindications (see below) <15 days: 50 mg/kg once daily ≥15 days: 80mg/kg once daily (max 4g daily) 2nd dose of ceftriaxone can be given between 12-24 hours following the first dose to facilitate ambulation – .
pier_first_line_antibiotic_guide_v_3_4_13_3_18__2_.docx