Depends on time frame EXAMPLE: RENAL ALLOGRAFT Hyperacute IMMEDIATE, PRE-FORMED ANTIBODIES (ABO) ? HOW FORMED KIDNEY EXAMPLE: CYANOTIC, MOTTLED NECROTIZING VASCULITIS, THROMBOSIS, ISCHEMIC NECROSIS OF GRAFT CROSSMATCH: CELLS W/ RECIPIENT SERUM Acute DAYS, WEEKS, MAYBE YEARS IF IMMUNOSUPPRESSION DECREASED CELLULAR: LYMPHOCYTIC INFILTRATION (CD4, CD8) TUBULITIS ENDOTHELIALITIS RESPONDS TO IMMUNOSUPPRESSION CAN MIMIC CYCLOSPORINE TOXICITY VASCULAR: ACUTE AND SUBACUTE VASCULAR INJURY INTIMAL PROLIFERATION, LUMEN COMPROMISE, ISCHEMIA Chronic CORRELATES WITH PRIOR EPISODES OF ACUTE REJECTION, CUMULATIVE EFFECT VESSELS: INTIMAL FIBROSIS INTERSTITIAL FIBROSIS AND ATROPHY Methods of Improving Graft Survival Compatibilitiy: ABO: CROSSMATCH, ESSENTIAL HLA antigens
Depends on time frame EXAMPLE: RENAL ALLOGRAFT Hyperacute IMMEDIATE, PRE-FORMED ANTIBODIES (ABO) ? HOW FORMED KIDNEY EXAMPLE: CYANOTIC, MOTTLED NECROTIZING VASCULITIS, THROMBOSIS, ISCHEMIC NECROSIS OF GRAFT CROSSMATCH: CELLS W/ RECIPIENT SERUM Acute DAYS, WEEKS, MAYBE YEARS IF IMMUNOSUPPRESSION DECREASED CELLULAR: LYMPHOCYTIC INFILTRATION (CD4, CD8) TUBULITIS ENDOTHELIALITIS RESPONDS TO IMMUNOSUPPRESSION CAN MIMIC CYCLOSPORINE TOXICITY VASCULAR: ACUTE AND SUBACUTE VASCULAR INJURY INTIMAL PROLIFERATION, LUMEN COMPROMISE, ISCHEMIA Chronic CORRELATES WITH PRIOR EPISODES OF ACUTE REJECTION, CUMULATIVE EFFECT VESSELS: INTIMAL FIBROSIS INTERSTITIAL FIBROSIS AND ATROPHY Methods of Improving Graft Survival Compatibilitiy: ABO: CROSSMATCH, ESSENTIAL HLA antigens
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