Table 2: Percentage sequence identities between genes of HIV-1 isolate used in VIA and Ad5-based regimen gene inserts Vaccine candidate and HIV-1 gene insert VIA HIV-1 isolate (clade), gene accession and % identity with vaccine gene insert HIV-1 Insert Insert Clade IIIB (B) CH77 (B) CH106 (B) ELI (AD) 247FV2 (C) 97ZA012 (C) gene isolate accession AAB50258 AET76070 AET75990 AAA44324 ** AAK30990 Gag CAM-1 B BAA00992 96% 92% 92% 91% 84% 84% AAB50259 AET76071 AET75991 AAA44325 ** AAK30991 MRKAd5 Pol IIIB (HXB2) B AAB50259 100% 94% 95% 95% 92% 92% AAB50263 ** AET75998 AAA44330 ** AAK30998 Nef JRFL B [48] 85% 82% 79% 75% 77% 80% AAB50258 AET76070 AET75990 AAA44324 ** AAK30990 Gag HXB2 B AAB50258 100% 92% 91% 89% 84% 84% VRC AAB50259 AET76071 AET75991 AAA44325 ** AAK30991 DNA/Ad5 Pol NL4-3 B AAA44988 97% 93% 95% 95% 92% 90% Nef B AAA44993 AAB50263 NA AET75998 AAA44330 ** AAK30998
Table 2: Percentage sequence identities between genes of HIV-1 isolate used in VIA and Ad5-based regimen gene inserts Vaccine candidate and HIV-1 gene insert VIA HIV-1 isolate (clade), gene accession and % identity with vaccine gene insert HIV-1 gene Insert isolate Clade Insert accession IIIB (B) CH77 (B) CH106 (B) ELI (AD) 247FV2 (C) 97ZA012 (C) MRKAd5 Gag CAM-1 B BAA00992 AAB50258 AET76070 AET75990 AAA44324 ** AAK30990 96% 92% 92% 91% 84% 84% Pol IIIB (HXB2) B AAB50259 AAB50259 AET76071 AET75991 AAA44325 ** AAK30991 100% 94% 95% 95% 92% 92% Nef JRFL B [48] AAB50263 ** AET75998 AAA44330 ** AAK30998 85% 82% 79% 75% 77% 80% VRC DNA/Ad5 Gag HXB2 B AAB50258 AAB50258 AET76070 AET75990 AAA44324 ** AAK30990 100% 92% 91% 89% 84% 84% Pol NL4-3 B AAA44988 AAB50259 AET76071 AET75991 AAA44325 ** AAK30991 97% 93% 95% 95% 92% 90% Nef B AAA44993 AAB50263 NA AET75998 AAA44330 ** AAK30998
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