studied. Systolic dysfunction intervals using a standard SCA or appropriate ICD discharge Canada NHMRC level II n=70 (22%) LGE– was defined as an LVEF SSFP-based cine pulse sequence hospitalisation for severe HF Patient characteristics: ≤55% because this value non–SCD LGE sequence: phase-sensitive corresponds to the lower limit SIGN: acceptable age = 62.0 ± 12.9 years; inversion recovery gradient-echo in LGE+ patients compared with those of the 95%CI in healthy quality with a male = 73%; pulse sequence that are LGE– subject. moderate risk of QRS interval = 131.9 ± bias Contrast agent: Exclusion criteria: patients 31.5 milliseconds; mmol/kg; Gadovist clinically suspected to have LBBB = 40%; HCM, restrictive CM Time delay: 10–15 minutes (sarcoidosis or amyloidosis), LVEF (CMR) = 32.6 ± 11.9%; LV function: Cine images were or arrhythmogenic right examined to determine LV and history of VA = 11%, ICM = ventricular CM. Patients right ventricular end-systolic 47%; were also excluded if volumes and end-diastolic standard contraindications NYHA class III–IV = 46%; volumes, in addition to LV mass by to LGE-CMR existed, semi-automated endocardial and medications: ACE inhibitor = inclusive of a GFR of epicardial contour tracing. 59%, ARB = 22%, -blockers ≤30 mL/min/1.73 m2 = 77% LGE diagnosis: The scoring of all LGE fibrosis patterns was as n=169 (53%) had NICM follows: n=50 (30%) LGE+ n=119 (70%) LGE– 1) subendocardial Median follow-up: 467 (IQR 2) mid-wall striae 16–1,422) days 3) mid-wall patchy 4) subepicardial 5) right ventricular insertion point 6) diffuse. Buss et al. Prospective N=210 consecutive patients Inclusion criteria: Scanner: 1.5-T scanner with a ICD implantation: Not described () cohort with DCM consecutive patients with cardiac phased array receiver coil
Canada NHMRC level II SIGN: acceptable quality with a moderate risk of bias n=70 (22%) LGE– Patient characteristics: age = 62.0 ± 12.9 years; male = 73%; QRS interval = 131.9 ± 31.5 milliseconds; LBBB = 40%; LVEF (CMR) = 32.6 ± 11.9%; history of VA = 11%, ICM = 47%; NYHA class III–IV = 46%; medications: ACE inhibitor = 59%, ARB = 22%, -blockers = 77% n=169 (53%) had NICM n=50 (30%) LGE+ n=119 (70%) LGE– Median follow-up: 467 (IQR 16–1,422) days studied. Systolic dysfunction was defined as an LVEF ≤55% because this value corresponds to the lower limit of the 95%CI in healthy subject. Exclusion criteria: patients clinically suspected to have HCM, restrictive CM (sarcoidosis or amyloidosis), or arrhythmogenic right ventricular CM. Patients were also excluded if standard contraindications to LGE-CMR existed, inclusive of a GFR of ≤30 mL/min/1.73 m2 intervals using a standard SSFP-based cine pulse sequence LGE sequence: phase-sensitive inversion recovery gradient-echo pulse sequence Contrast agent: mmol/kg; Gadovist Time delay: 10–15 minutes LV function: Cine images were examined to determine LV and right ventricular end-systolic volumes and end-diastolic volumes, in addition to LV mass by semi-automated endocardial and epicardial contour tracing. LGE diagnosis: The scoring of all LGE fibrosis patterns was as follows: 1) subendocardial 2) mid-wall striae 3) mid-wall patchy 4) subepicardial 5) right ventricular insertion point 6) diffuse. SCA or appropriate ICD discharge hospitalisation for severe HF non–SCD in LGE+ patients compared with those that are LGE– Buss et al. () Prospective cohort N=210 consecutive patients with DCM Inclusion criteria: consecutive patients with Scanner: 1.5-T scanner with a cardiac phased array receiver coil ICD implantation: Not described
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