NSCLC considered samples inadequate for mutation analysis Dingemans Conference EGFR and Retrospective 188 cases High resolution Archival FFPE Netherlands Not reported Test failures 2011 abstract KRAS mutation testing of patients where tissue melting following tissue analysis in with chemo-naive avilable sequencing NSCLC advanced NSCLC treated with a platinum doublet Halblass 2011 Conference Germany EGFR, ALK, Part prospective, 88 patients Not reported Various Reviewed Test failures BRAF and part retrospective archival FFPE abstract KRAS mutation testing of patients tissue analysis in NSCLC Subramonia Conference US EGFR mutation Retrospective 64 cases Diagnosed Not applicable Archival tissue On review. 2012 abstract testing in chart review of during 2010; adequacy of NSCLC patients with reviewed 2011 biopsy samples NSCLC; single for potential centre; testing Wu 2014 Conference US EGFR and Method 15 samples Not reported Cell enriched Reviewed Test failures abstract KRAS mutation development transfer; PCR archive FFPE testing in using previously tumour tissue NSCLC tested tissue; Single centre Madrid 2004 Full journal Philippines HER2-/neu Evaluation of 160 randomly Testing CISH Archival FFPE Test failures article testing in breast CISH assay; selected between primary breast cancer single centre HER2+ cases tumour tissue study Penault-Llorca Full journal France HER2 testing in Retrospective 710 Cases Cases between Not reported Archival FFPE Availability of 2008 article breast cancer testing of tissues 1982-2004 primary breast usable sample
NSCLC considered inadequate for mutation analysis samples Dingemans 2011 Conference abstract Netherlands EGFR and KRAS mutation analysis in NSCLC Retrospective testing of patients with chemo-naive advanced NSCLC treated with a platinum doublet 188 cases where tissue avilable Not reported High resolution melting following sequencing Archival FFPE tissue Test failures Halblass 2011 Conference abstract Germany EGFR, ALK, BRAF and KRAS mutation analysis in NSCLC Part prospective, part retrospective testing of patients 88 patients Not reported Various Reviewed archival FFPE tissue Test failures Subramonia 2012 Conference abstract US EGFR mutation testing in NSCLC Retrospective chart review of patients with NSCLC; single centre; 64 cases Diagnosed during 2010; reviewed 2011 Not applicable Archival tissue On review. adequacy of biopsy samples for potential testing Wu 2014 Conference abstract US EGFR and KRAS mutation testing in NSCLC Method development using previously tested tissue; Single centre 15 samples Not reported Cell enriched transfer; PCR Reviewed archive FFPE tumour tissue Test failures Madrid 2004 Full journal article Philippines HER2-/neu testing in breast cancer Evaluation of CISH assay; single centre study 160 randomly selected HER2+ cases Testing between CISH Archival FFPE primary breast tumour tissue Test failures Penault-Llorca 2008 Full journal article France HER2 testing in breast cancer Retrospective testing of tissues 710 Cases Cases between 1982-2004 Not reported Archival FFPE primary breast Availability of usable sample
1331-Contracted_Assessment_Report-accessible.docx