The 5D framework: a clinical primer for fecal microbiota transplantation to treat <em>Clostridium difficile</em> infection. Gastrointest Endosc [Internet]. 2017 Jul 26; Available from: http://dx.doi.org/10.1016/j.gie.2017.05.036 8.2.2. FMT should be offered with caution to immunosuppressed Thank you for this comment. Immunosuppression patients, in whom FMT appears efficacious without significant and FMT: additional adverse effects (strong). We agree. 8.2.3. Other Recommendation: Thank you for this comment. and FMT: FMT should be offered to those with recurrent CDI and inflammatory bowel disease (strong). FMT should be considered for appropriate patients with recurrent CDI regardless of other comorbidities (conditional). We agree. 8.3.1. General Related or unrelated donors should both be considered Thank you for this comment. approach to donor acceptable. However, where possible, FMT is best sourced from a selection: centralised stool bank, from a healthy unrelated donor (conditional). We agree. 8.3.2. Age and BMI People should only be considered as potential FMT donors if they Thank you for this comment. restrictions for are ≥18 and ≤60 years old, and have a BMI of <30 kg/m2 potential donors: (conditional). We agree. 8.3.3. General A donor-screening history/ questionnaire is mandatory (Table 2) approach to the donor (strong). screening assessment: Receipt of antimicrobials within the past three months.
The 5D framework: a clinical primer for fecal microbiota transplantation to treat <em>Clostridium difficile</em> infection. Gastrointest Endosc [Internet]. 2017 Jul 26; Available from: http://dx.doi.org/10.1016/j.gie.2017.05.036 8.2.2. Immunosuppression and FMT: FMT should be offered with caution to immunosuppressed patients, in whom FMT appears efficacious without significant additional adverse effects (strong). We agree. Thank you for this comment. 8.2.3. Other and FMT: Recommendation: FMT should be offered to those with recurrent CDI and inflammatory bowel disease (strong). FMT should be considered for appropriate patients with recurrent CDI regardless of other comorbidities (conditional). We agree. Thank you for this comment. 8.3.1. General approach to donor selection: Related or unrelated donors should both be considered acceptable. However, where possible, FMT is best sourced from a centralised stool bank, from a healthy unrelated donor (conditional). We agree. Thank you for this comment. 8.3.2. Age and BMI restrictions for potential donors: People should only be considered as potential FMT donors if they are ≥18 and ≤60 years old, and have a BMI of <30 kg/m2 (conditional). We agree. Thank you for this comment. 8.3.3. General approach to the donor screening assessment: A donor-screening history/ questionnaire is mandatory (Table 2) (strong). Receipt of antimicrobials within the past three months.
fmt-appendices-a-e.docx