Synergy rates for polymyxin and carbapenem combination by type of bacteria Figure 1: Study names are comprised of first author and either publication year or convention name and year accordingly. Subgroups within studies (according to resistance profile, antibiotic used, etc – see Methods section) were listed separately and denoted by continuous numbering in parenthesis Figure 2: All-cause mortality in observational studies comparing colistin or polymyxin B vs. comparator antibiotics for sepsis 1 1 Betrosian 2008 was a quasi-randomized study, using alternation for patient allocation Figure 3: Adjusted all-cause mortality in observational studies comparing colistin or polymyxin B vs. comparator antibiotics for sepsis Figure 4: Nephrotoxicity for patients treated with colistin vs. comparator antibiotics in observational studies METHODS Trial design: Randomized, open-label, controlled clinical trial (RCT). Setting: Multicenter study including the following sites/ departments: Italy, Rome: Universita Cattolica del Sacro Cuore, Agostino Gemelli Hospital. Four departments: ICU, Infectious Diseases, Internal Medicine and Pneumology Greece, Athens: Laikon Hospital, all departments
Figure 1: Synergy rates for polymyxin and carbapenem combination by type of bacteria Study names are comprised of first author and either publication year or convention name and year accordingly. Subgroups within studies (according to resistance profile, antibiotic used, etc – see Methods section) were listed separately and denoted by continuous numbering in parenthesis Figure 2: All-cause mortality in observational studies comparing colistin or polymyxin B vs. comparator antibiotics for sepsis 1 1 Betrosian 2008 was a quasi-randomized study, using alternation for patient allocation Figure 3: Adjusted all-cause mortality in observational studies comparing colistin or polymyxin B vs. comparator antibiotics for sepsis Figure 4: Nephrotoxicity for patients treated with colistin vs. comparator antibiotics in observational studies METHODS Trial design: Randomized, open-label, controlled clinical trial (RCT). Setting: Multicenter study including the following sites/ departments: Italy, Rome: Universita Cattolica del Sacro Cuore, Agostino Gemelli Hospital. Four departments: ICU, Infectious Diseases, Internal Medicine and Pneumology Greece, Athens: Laikon Hospital, all departments
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