Carafiello et al Retrospective CS Patients with primary or secondary lung tumours treated by Intervention: CT-guided 1. Adverse events: Classified as side effects and major and (2012) MTA or RFA, MTA minor adverse events in accordance with the classification Level IV proposed by the Society of Interventional Radiology (SIR). Italy Patients were judged to have inoperable disease or refused Conscious sedation Risk of bias: High Patients were evaluated for the presence of post ablation surgery Duration: total ablation Hospital setting syndrome and pain was measured with VAS. N = 16 with MTA (17) time of 10 minutes NR Mean tumour size(range): 37.5 (28–47) mm Comparator: N/A M/F ratio: NR Mean age (range): 74.75 (40–84) years Reasons for inoperability: 9 based on advanced stage, 6 comorbidities, 1 with metastases from an advanced primary Chung et al 2014 Retrospective CS Patients with lung tumours treated by MTA underperformed Intervention: 1. Adverse events: defined according tothe standardization with normal respiration under conscious sedation (NR-CS) Percutaneous MTA with of terminology and reporting criteria set out by the United Kingdom Level IV or high-frequency jet ventilation under general anaesthesia HFJV under GA with CT International Working Group on Image- Guided Tumour Risk of bias: High (HFJV-GA) guidance Ablation Hospital setting N = 39 (63) Anaesthesiologist time NR mean (SD): 27.78 (17.78) Mean (SD) tumour size NR-CS: 27.38 (14.73), HFJV-GA: 16.09 (9.21) Comparator: Percutaneous MTA with M/F ratio: 24:15 NR under CS with CT Mean age HF JV-GA (range): 66.39 (12.20), NR-CS: 69.15 guidance (15.59) years Anaesthesiologist time Other details NR mean (SD): 21.08 (8.45)
Carafiello et al (2012) Italy Retrospective CS Level IV Risk of bias: High Hospital setting NR Patients with primary or secondary lung tumours treated by MTA or RFA, Patients were judged to have inoperable disease or refused surgery N = 16 with MTA (17) Mean tumour size(range): 37.5 (28–47) mm M/F ratio: NR Mean age (range): 74.75 (40–84) years Reasons for inoperability: 9 based on advanced stage, 6 comorbidities, 1 with metastases from an advanced primary Intervention: CT-guided MTA Conscious sedation Duration: total ablation time of 10 minutes Comparator: N/A 1. Adverse events: Classified as side effects and major and minor adverse events in accordance with the classification proposed by the Society of Interventional Radiology (SIR). Patients were evaluated for the presence of post ablation syndrome and pain was measured with VAS. Chung et al 2014 United Kingdom Retrospective CS Level IV Risk of bias: High Hospital setting NR Patients with lung tumours treated by MTA underperformed with normal respiration under conscious sedation (NR-CS) or high-frequency jet ventilation under general anaesthesia (HFJV-GA) N = 39 (63) Mean (SD) tumour size NR-CS: 27.38 (14.73), HFJV-GA: 16.09 (9.21) M/F ratio: 24:15 Mean age HF JV-GA (range): 66.39 (12.20), NR-CS: 69.15 (15.59) years Other details NR Intervention: Percutaneous MTA with HFJV under GA with CT guidance Anaesthesiologist time mean (SD): 27.78 (17.78) Comparator: Percutaneous MTA with NR under CS with CT guidance Anaesthesiologist time mean (SD): 21.08 (8.45) 1. Adverse events: defined according tothe standardization of terminology and reporting criteria set out by the International Working Group on Image- Guided Tumour Ablation
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