Table Comparative summary of characteristics of clinical studies relating to external expert opinion: Scenario 1 studies Study ID Study characteristics Population Prior test Intervention Comparator Outcomes Country ALL SURGICAL - - - - - - PATHOLOGY Cook 2001 Retrospective review of all All histopathology Initial diagnosis SO provided by “external Initial SO consultation rate cases sent for SO during cases; any organ or no diagnosis experts” from other diagnosis Specimen anatomical site 1998, compared to 1990, pathology laboratories in the system rendered Nature of initial pathology opinion from two large district UK. SO was mainly N=128 casesa (no/differential/provisional general hospitals requested by pathologistsb diagnosis) histopathology laboratories. at Portsmouth Hospitals Reason for referral National Health Service United Kingdom Diagnostic accuracy (NHS) Trust. (concordance/discordance; major discrepancies) Turnaround time Nature of expert diagnosis (no diagnosis/confident diagnosis) Hsu 2010 Retrospective Anatomic Initial diagnosis EEO provided by 65 Initial Annual SO consultation rate review of pathology; any or no diagnosis pathologists with diagnosis Tissue origin of specimens consecutive cases sent for organ system rendered subspecialty expertise from Nature of initial pathology opinion extra-departmental anatomic teaching hospitals across N=2686 cases (no diagnosis, tentative diagnosis) pathology consultation by Taiwan. Additional Diagnostic accuracy (concordance, Taiwan Society of Pathology specialised testing discordance; major and minor (TSP) members from 2003 performed as required. EEO discrepancies) to 2006. TSP received requested by 224 Turnaround time research funding for EEO pathologists from 79 Use of special stains provided. Study does not institutes across Taiwan. Characteristics of referring include cases sent directly Reasons for consultation not pathologists to Taiwan-based or provided. Characteristics of EEO pathologists overseas consultants. Taiwan
Table Comparative summary of characteristics of clinical studies relating to external expert opinion: Scenario 1 studies Study ID Study characteristics Country Population Prior test Intervention Comparator Outcomes ALL SURGICAL PATHOLOGY - - - - - - Cook 2001 Retrospective review of all cases sent for SO during 1998, compared to 1990, from two large district general hospitals histopathology laboratories. United Kingdom All histopathology cases; any organ system N=128 casesa Initial diagnosis or no diagnosis rendered SO provided by “external experts” from other pathology laboratories in the UK. SO was mainly requested by pathologistsb at Portsmouth Hospitals National Health Service (NHS) Trust. Initial diagnosis SO consultation rate Specimen anatomical site Nature of initial pathology opinion (no/differential/provisional diagnosis) Reason for referral Diagnostic accuracy (concordance/discordance; major discrepancies) Turnaround time Nature of expert diagnosis (no diagnosis/confident diagnosis) Hsu 2010 Retrospective review of consecutive cases sent for extra-departmental anatomic pathology consultation by Taiwan Society of Pathology (TSP) members from 2003 to 2006. TSP received research funding for EEO provided. Study does not include cases sent directly to Taiwan-based or overseas consultants. Taiwan Anatomic pathology; any organ system N=2686 cases Initial diagnosis or no diagnosis rendered EEO provided by 65 pathologists with subspecialty expertise from teaching hospitals across Taiwan. Additional specialised testing performed as required. EEO requested by 224 pathologists from 79 institutes across Taiwan. Reasons for consultation not provided. Initial diagnosis Annual SO consultation rate Tissue origin of specimens Nature of initial pathology opinion (no diagnosis, tentative diagnosis) Diagnostic accuracy (concordance, discordance; major and minor discrepancies) Turnaround time Use of special stains Characteristics of referring pathologists Characteristics of EEO pathologists
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