Table Symptom improvement in lung cancer patients treated palliatively with RFA () № of lesions with № of lesions with Symptom № of lesions treated symptom improvement symptom recurrence (%) Pain 20 19 7 (37) Haemoptysis 3 3 2 (67) Cough 4 4 1 (25) Effectiveness of radiotherapy for palliation of advanced-stage lung cancer The effectiveness of radiotherapy for palliative treatment of advanced stage lung cancer was recently reported in a Cochrane review by Stevens et al (). The review included 13 RCTs that compared the effects of radiotherapy fractionation schedules on symptom improvement and overall survival. The authors noted that all of the included studies reported a benefit of radiotherapy on symptom improvement, but concluded that no strong evidence for higher doses were associated with better or longer lasting palliation. Quality of life The overall survival in patients who have good or poor performance status, with quality of evidence ratings for the reported relative effect, are presented in Table 57. Table Effectiveness and quality of evidence for palliative radiotherapy regimens () Illustrative comparative Relative No of Quality of risks (95% CI) effect patients the evidence Outcomes Less More (95% CI) (studies) (GRADE) Comments fractions fractions 1-year overall Mean 25.6% Mean 33.3% 1,081 NO summary statistic ⨁⨁⨀⨀ survival in LOW due to heterogeneity, (9.4–45.7%) (11.4–46.2%) (8 studies) patients of good incomplete data – performance unable to source status missing data from authors 1-year overall Mean 14.6% Mean 17.5% RR 0.96 911 Incomplete data - ⨁⨁⨁⨀ survival in MODERATE unable to source (1.3–29.5%) (9.1–28.6%) (0.91 to 1.02) (7 studies) patients of poor missing data from performance authors status < CI = confidence interval; NR = not reported; RR = relative risk > GRADE Working Group grades of evidence (Guyatt et al., 2013)
Table Symptom improvement in lung cancer patients treated palliatively with RFA () Symptom № of lesions treated № of lesions with symptom improvement № of lesions with symptom recurrence (%) Pain 20 19 7 (37) Haemoptysis 3 3 2 (67) Cough 4 4 1 (25) Effectiveness of radiotherapy for palliation of advanced-stage lung cancer The effectiveness of radiotherapy for palliative treatment of advanced stage lung cancer was recently reported in a Cochrane review by Stevens et al (). The review included 13 RCTs that compared the effects of radiotherapy fractionation schedules on symptom improvement and overall survival. The authors noted that all of the included studies reported a benefit of radiotherapy on symptom improvement, but concluded that no strong evidence for higher doses were associated with better or longer lasting palliation. Quality of life The overall survival in patients who have good or poor performance status, with quality of evidence ratings for the reported relative effect, are presented in Table 57. Table Effectiveness and quality of evidence for palliative radiotherapy regimens () Illustrative risks comparative (95% CI) Relative effect No of patients Quality of the evidence Outcomes Less fractions More fractions (95% CI) (studies) (GRADE) Comments 1-year overall survival in patients of good performance status Mean 25.6% (9.4–45.7%) Mean 33.3% (11.4–46.2%) 1,081 (8 studies) ⨁⨁⨀⨀ LOW NO summary statistic due to heterogeneity, incomplete data – unable to source missing data from authors 1-year overall survival in patients of poor performance status Mean 14.6% (1.3–29.5%) Mean 17.5% (9.1–28.6%) RR 0.96 (0.91 to 1.02) 911 (7 studies) ⨁⨁⨁⨀ MODERATE Incomplete data - unable to source missing data from authors < CI = confidence interval; NR = not reported; RR = relative risk > GRADE Working Group grades of evidence (Guyatt et al., 2013)
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