probabilities of these treatment-related complications, an Australian quality of life study from the New South Wales Cancer Registry paper () was used. The probability of erectile dysfunction was 50 per cent for radical prostatectomy and 33 per cent for external beam radiotherapy, with a weighted (50/50, see Subsection D.4) average of 41.5 per cent in the “intermediate to high risk prostate cancer” health state. The probability of urinary incontinence was 10 per cent for radical prostatectomy and 2.4 per cent for external beam radiotherapy, with a weighted (50/50, see Subsection D.4) average of 6.2 per cent in the “intermediate to high risk prostate cancer” health state. A summary of each of the translational issues discussed in Section C and their use in Section D is provided in Table 46. Table Example of summary of results of pre-modelling studies and their uses in the economic evaluation Pre-modelling Results used in Section study Results used in Section D Subsection D.6 Applicability Subsection C.2 Comparison of The economic model is D.2 Sensitivity analyses D.6 patient and based on the Australian will be performed intervention patient population. with the lower and characteristics upper values of the between the key 95% CIs for accuracy clinical studies and results. Also, Australian registry Australia-specific accuracy results will data, Population 1 be used (sensitivity 54.3%, specificity 87.2%), obtained from a subsample of three, Australian studies. Subsection C.2 Comparison of The economic model is D.2 Sensitivity analyses D.6 patient and based on the Australian will be performed intervention with the lower and patient population. characteristics upper values of the between the key 95% CIs for accuracy clinical studies and results. Australian registry data, Population 2 Extrapolation Subsection C.3 Literature review Alignment of transition D.4 None NA for prostate cancer probabilities with the mortality and the evaluation for MR-guided impact of false biopsy procedures for diagnosis on diagnosis of PCa (CA 1424). prognosis. No impact of false diagnosis on prognosis.
probabilities of these treatment-related complications, an Australian quality of life study from the New South Wales Cancer Registry paper () was used. The probability of erectile dysfunction was 50 per cent for radical prostatectomy and 33 per cent for external beam radiotherapy, with a weighted (50/50, see Subsection D.4) average of 41.5 per cent in the “intermediate to high risk prostate cancer” health state. The probability of urinary incontinence was 10 per cent for radical prostatectomy and 2.4 per cent for external beam radiotherapy, with a weighted (50/50, see Subsection D.4) average of 6.2 per cent in the “intermediate to high risk prostate cancer” health state. A summary of each of the translational issues discussed in Section C and their use in Section D is provided in Table 46. Table Example of summary of results of pre-modelling studies and their uses in the economic evaluation Section Pre-modelling study Results used in Section D Results used in Subsection D.6 Applicability Subsection C.2 Comparison of patient and intervention characteristics between the key clinical studies and Australian registry data, Population 1 The economic model is based on the Australian patient population. D.2 Sensitivity analyses will be performed with the lower and upper values of the 95% CIs for accuracy results. Also, Australia-specific accuracy results will be used (sensitivity 54.3%, specificity 87.2%), obtained from a subsample of three, Australian studies. D.6 Subsection C.2 Comparison of patient and intervention characteristics between the key clinical studies and Australian registry data, Population 2 The economic model is based on the Australian patient population. D.2 Sensitivity analyses will be performed with the lower and upper values of the 95% CIs for accuracy results. D.6 Extrapolation Subsection C.3 Literature review for prostate cancer mortality and the impact of false diagnosis on prognosis. Alignment of transition probabilities with the evaluation for MR-guided biopsy procedures for diagnosis of PCa (CA 1424). No impact of false diagnosis on prognosis. D.4 None NA
1397_Final_MSAC_Assessment_Report.docx