Results of assessment Relevant studies for assessment The searches yielded 32 studies that were deemed relevant for this assessment. A summary of these studies is provided in Table 11. Table 11: Summary of studies included in the assessment Reviewed for assessment of : Study Study design Search 1 Amir 2011 Meta-analysis Are patients with breast cancer and taking Becker 2012 Meta-analysis aromatase inhibitors at high risk of fractures? Bell 2011 Comparative study (and related questions) Eastell 2011 RCT Edwards 2011 Systematic review and case series Goss 2013 RCT Kalder 2013 RCT Neuner 2011 Population study, retrospective Search 2 Marshall 1996 Meta-analysis Are DXA scans safe and effective? Homik 1999 HTA report (and related questions) Rud 2007 Meta-analysis Kanis 2009 Meta-analysis Lim 2009 Review and position statement Cummins 2011 Case control study, retrospective Hailey 1998 HTA report Search 3 Brufsky 2012 (Z-FAST) RCT open label Are anti-resorptives or other BMD treatments Coleman 2013 (ZO-FAST) RCT open label safe and effective? Llombart 2012 (E-ZO-FAST) RCT open label (and related questions) Takahashi 2012 RCT open label Nuzzo 2012 (HOBOE) RCT Phase III Safra 2011 RCT Phase II Lee 2011 Comparative study Lester 2012 (ARIBON) RCT Markopoulos 2010 (ARBI) RCT phase II open-label Rhee 2013 RCT Van Poznak 2010 (SABRE) RCT phase III Ellis 2009 RCT phase III Rastelli 2011 RCT phase II Martyn-St James 2009 Meta-analysis Search 4 Ito 2012 Cost-utility analysis Cost-effectiveness of DXA and treatment? Logman 2010 Cost-utility analysis (and related questions) Mueller 2009 Cost-utility analysis Sources: (, , , , , , , , , , , , , , , , , , , , , , , , , , , , , ) Are post-menopausal women with breast cancer on aromatase inhibitors at high risk of minimal trauma fractures? A summary of the key features, results and quality appraisal are provided in Tables 12 and 13. Additional information on these studies is provided in Appendix C.
Results of assessment Relevant studies for assessment The searches yielded 32 studies that were deemed relevant for this assessment. A summary of these studies is provided in Table 11. Table 11: Summary of studies included in the assessment Reviewed for assessment of : Study Study design Search 1 Are patients with breast cancer and taking aromatase inhibitors at high risk of fractures? (and related questions) Amir 2011 Becker 2012 Bell 2011 Eastell 2011 Edwards 2011 Goss 2013 Kalder 2013 Neuner 2011 Meta-analysis Meta-analysis Comparative study RCT Systematic review and case series RCT RCT Population study, retrospective Search 2 Are DXA scans safe and effective? (and related questions) Marshall 1996 Homik 1999 Rud 2007 Kanis 2009 Lim 2009 Cummins 2011 Hailey 1998 Meta-analysis HTA report Meta-analysis Meta-analysis Review and position statement Case control study, retrospective HTA report Search 3 Are anti-resorptives or other BMD treatments safe and effective? (and related questions) Brufsky 2012 (Z-FAST) Coleman 2013 (ZO-FAST) Llombart 2012 (E-ZO-FAST) Takahashi 2012 Nuzzo 2012 (HOBOE) Safra 2011 Lee 2011 Lester 2012 (ARIBON) Markopoulos 2010 (ARBI) Rhee 2013 Van Poznak 2010 (SABRE) Ellis 2009 Rastelli 2011 Martyn-St James 2009 RCT open label RCT open label RCT open label RCT open label RCT Phase III RCT Phase II Comparative study RCT RCT phase II open-label RCT RCT phase III RCT phase III RCT phase II Meta-analysis Search 4 Cost-effectiveness of DXA and treatment? (and related questions) Ito 2012 Logman 2010 Mueller 2009 Cost-utility analysis Cost-utility analysis Cost-utility analysis Sources: (, , , , , , , , , , , , , , , , , , , , , , , , , , , , , ) Are post-menopausal women with breast cancer on aromatase inhibitors at high risk of minimal trauma fractures? A summary of the key features, results and quality appraisal are provided in Tables 12 and 13. Additional information on these studies is provided in Appendix C.
1313_BMDusingDXAAromataseInhibitor_AttA_FinalAssessmentReport%20-accessible.docx