The patient ID is given in bold when a genetic diagnosis could be made. ID Cardiac Extra cardiac Prodrome Viral Age of SF LV- Rhythm CK Family Cardiac Endpoint phenotype features etiology onset (%) EF disorder (U/l) history screening first (%) degree period relatives F1P1 DCM with no no uk 15 y 12 uk no 46 Father DCM yes, father - 7 yr features of + myopathy DCM, brother LVNC Brother DCM DCM with Dysplastic with features features of tricuspid of LVNC LVNC valve F1P2 DCM with no no uk 14 y 27 43 no uk Father DCM yes, father - 5 yr features of (last + myopathy DCM, sister LVNC visit) Sister DCM DCM with Dysplastic with features features of tricuspid of LVNC LVNC valve DCM facial coughing 1 neg. 10 y 7 uk mild LV 199 neg. Not advised LVAD, 1 yr:9 F2P1 dysmorphisms: w conduction HtX months synophris, defect strabismus F3P1 DCM no no IgG antenatal 26 37 no 404 Maternal yes, normal - 10 yr EBV grandmother pos. in DCM 32 blood F3P2 DCM no no NP 8 y 30 uk no NP Mother DCM, yes, mother - 10 yr Maternal DCM grandmother DCM F3P3 DCM NP uk NP neonatal <10 uk no NP DCM 3rd yes, normal partly 23 yr (day 8) degree family recovered member F4P1 DCM no coughing, Corona 7 y 11 uk atrial neg. yes, mother EP study 4 yr tiredness 1 virus tachycardia polymorphic with w pos. in After ventricular ablation, blood ablation heart rhythm ICD atrial disorder bigeminy,
The patient ID is given in bold when a genetic diagnosis could be made. ID Cardiac phenotype Extra cardiac features Prodrome Viral etiology Age of onset SF (%) LV- EF (%) Rhythm disorder CK (U/l) Family history Cardiac screening first degree relatives Endpoint period F1P1 DCM with features of LVNC Dysplastic tricuspid valve no no uk 15 y 12 uk no 46 Father DCM + myopathy Brother DCM with features of LVNC yes, father DCM, brother DCM with features of LVNC - 7 yr F1P2 DCM with features of LVNC Dysplastic tricuspid valve no no uk 14 y 27 43 (last visit) no uk Father DCM + myopathy Sister DCM with features of LVNC yes, father DCM, sister DCM with features of LVNC - 5 yr F2P1 DCM facial dysmorphisms: synophris, strabismus coughing 1 w neg. 10 y 7 uk mild LV conduction defect 199 neg. Not advised LVAD, HtX 1 yr:9 months F3P1 DCM no no IgG EBV pos. in blood antenatal 26 37 no 404 Maternal grandmother DCM 32 yes, normal - 10 yr F3P2 DCM no no NP 8 y 30 uk no NP Mother DCM, Maternal grandmother DCM yes, mother DCM - 10 yr F3P3 DCM NP uk NP neonatal (day 8) <10 uk no NP DCM 3rd degree family member yes, normal partly recovered 23 yr F4P1 DCM no coughing, tiredness 1 w Corona virus pos. in blood 7 y 11 uk atrial tachycardia After ablation atrial bigeminy, neg. yes, mother polymorphic ventricular heart rhythm disorder EP study with ablation, ICD 4 yr
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