Table 16: Additional Gonadal Histopathology Observations in Male [test organism]. Additional Diagnostic Observations1 Decreased Increased Vascular Asynchronous Altered Proportions of Treatment (mg a.i./L) Granulomatous Proportion of or Interstitial Gonad Spermatocytes or Inflammation [measured] Severity Spermatogonia Proteinaceous Fluid Development Spermatids n Incidence n Incidence n Incidence n Incidence n Incidence 0 8 8 8 8 8 8 8 8 8 8 Control (dilution water only), 1 if used 2 3 4 0 Solvent control, if used 1 2 3 4 0 Test concentration1 1 2 3 4 0 Test concentration 2 1
Table 16: Additional Gonadal Histopathology Observations in Male [test organism]. Treatment (mg a.i./L) [measured] Additional Diagnostic Observations1 Severity Decreased Proportion of Spermatogonia Increased Vascular or Interstitial Proteinaceous Fluid Asynchronous Gonad Development Altered Proportions of Spermatocytes or Spermatids Granulomatous Inflammation n Incidence n Incidence n Incidence n Incidence n Incidence Control (dilution water only), if used 0 8 8 8 8 8 8 8 8 8 8 1 2 3 4 Solvent control, if used 0 1 2 3 4 Test concentration1 0 1 2 3 4 Test concentration 2 0 1
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