The GRADE Working Group grades of evidence () presented in the tables below are defined as: ⨁⨁⨁⨁ High quality: We are very confident that the true effect lies close to that of the estimate of effect. ⨁⨁⨁⨀ Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. ⨁⨁⨀⨀ Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. ⨁⨀⨀⨀ Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. Table Evidence profile table for the accuracy of LGE-CMR compared with the reference standards for patients with HF symptoms (suspected of DCM) or DCM patients Outcome No. of participants, Risk of bias Indirectness Inconsistency Imprecision Other Effect per 1,000 QoE No. of studies considerations patients/year Importance Study design Study prevalence - LGE-CMR to diagnose DCM - - - - - - 39.7% (ref. std. = available diagnostic data) True N=54 patients Not serious Not serious Not serious Not serious None 330 (282–365) High positives K=1 study (QUADAS-2 ⨁⨁⨁⨁ Cross-sectional low risk of (cohort-type accuracy study) bias) False 67 (32–115) negatives True N=82 patients Not serious Not serious Not serious Not serious None 561 (513–585) High negatives K=1 study (QUADAS-2 ⨁⨁⨁⨁ Cross-sectional low risk of (cohort-type accuracy study) bias) False 42 (18–90) positives - LGE-CMR to diagnose non-ischaemic - - - - - 63.1% -
The GRADE Working Group grades of evidence () presented in the tables below are defined as: ⨁⨁⨁⨁ High quality: We are very confident that the true effect lies close to that of the estimate of effect. ⨁⨁⨁⨀ Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. ⨁⨁⨀⨀ Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. ⨁⨀⨀⨀ Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. Table Evidence profile table for the accuracy of LGE-CMR compared with the reference standards for patients with HF symptoms (suspected of DCM) or DCM patients Outcome No. of participants, No. of studies Study design Risk of bias Indirectness Inconsistency Imprecision Other considerations Effect per 1,000 patients/year Study prevalence QoE Importance - LGE-CMR to diagnose DCM (ref. std. = available diagnostic data) - - - - - 39.7% - True positives False negatives N=54 patients K=1 study Cross-sectional (cohort-type accuracy study) Not serious (QUADAS-2 low risk of bias) Not serious Not serious Not serious None 330 (282–365) 67 (32–115) High ⨁⨁⨁⨁ True negatives False positives N=82 patients K=1 study Cross-sectional (cohort-type accuracy study) Not serious (QUADAS-2 low risk of bias) Not serious Not serious Not serious None 561 (513–585) 42 (18–90) High ⨁⨁⨁⨁ - LGE-CMR to diagnose non-ischaemic - - - - - 63.1% -
1393-CMRforDCM.docx