Bacterial Repeat Dose Carcinogenicity In vitro In vivo mutagenicity genotoxicity genotoxicity toxicity toxicity Structural Yes Yes Yes Yes Yes Yes alert? No No No No No No Data Yes Yes Yes Yes Yes Yes available? No No No No No No Data Source (study, , read across, journal, model) Effects Yes Yes Yes Yes Yes Yes observed? No No No No No No NA NA NA NA NA NA Result (if study equivocal LOAEL LOAEL = conducted) equivocal equivocal = NA = not applicable, i.e. study not conducted Acute Oral Toxicity Dose Number Mortality Signs of toxicity mg/kg bw of Animals Acute Dermal Toxicity Dose Number Mortality Signs of local toxicity Signs of systemic toxicity mg/kg bw of Animals Acute Inhalation Toxicity Concentration Number and Sex Mortality Signs of toxicity <units> of Animals Nominal Actual Eye Irritation Scores Lesion Mean score* Maximum Maximum Duration Maximum Value at End of Animal no. Score of Any Effect Observation Period 1 2 3 Conjunctiva: redness Conjunctiva: chemosis Conjunctiva:discharge Corneal opacity Iridial inflammation *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Skin Irritation Scores
Bacterial mutagenicity In vitro genotoxicity In vivo genotoxicity Repeat Dose toxicity toxicity Carcinogenicity Structural alert? Yes No Yes No Yes No Yes No Yes No Yes No Data available? Yes No Yes No Yes No Yes No Yes No Yes No Data Source (study, , read across, journal, model) Effects observed? Yes No NA Yes No NA Yes No NA Yes No NA Yes No NA Yes No NA Result (if study conducted) equivocal equivocal equivocal LOAEL = LOAEL = NA = not applicable, i.e. study not conducted Acute Oral Toxicity Dose mg/kg bw Number of Animals Mortality Signs of toxicity Acute Dermal Toxicity Dose mg/kg bw Number of Animals Mortality Signs of local toxicity Signs of systemic toxicity Acute Inhalation Toxicity Concentration <units> Number and Sex of Animals Mortality Signs of toxicity Nominal Actual Eye Irritation Scores Lesion Mean score* Animal no. Maximum Score Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Conjunctiva: redness Conjunctiva: chemosis Conjunctiva:discharge Corneal opacity Iridial inflammation *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Skin Irritation Scores
Form_CUP-1.docx