One CR MDR Positive vs. 2/20 clinical isolate: blood culture Clinical strain: 13/20 imipenem MIC at 24h vs. 3/20 (p<0.05 for 32 colistin MIC all) 8 Aoki In-vivo - BALB/c female imipenem 1 Survival, 90% survival in Significant P. aeruginosa, 2008[] mice pneumonia model PAO1 strain and lung bacterial combination vs 10% effects on (intranasal and 6 clinical strains burden in monotherapy, survival and subcutaneous) reduced bacterial bacterial burden burden with colistin Song In-vivo randomized Imipenem 1 Lung Combi 7.15 ± 3.56 vs. In-vivo bacterial A. baumannii, 2009 [] (neutropenic mice with clinical CR bacterial Colistin alone 6.35 ± load, bacteremia pneumonia following isolate OXA-51 loads at 48h 0.98 and mortality tracheal positive. Combi 0/3 vs. A. baumannii inoculation) Imipenem MIC Colistin alone 0/3 64, colistin Bacteremia Combi 1/3 vs. ≤0.5 eradication at Colistin alone 1/3 48h Mortality at 48h
One CR MDR clinical isolate: imipenem MIC 32 colistin MIC 8 Positive blood culture at 24h vs. 2/20 Clinical strain: 13/20 vs. 3/20 (p<0.05 for all) Aoki 2008[] In-vivo - BALB/c female mice pneumonia model (intranasal and subcutaneous) imipenem P. aeruginosa, 1 PAO1 strain and 6 clinical strains Survival, lung bacterial burden 90% survival in combination vs 10% in monotherapy, reduced bacterial burden Significant effects on survival and bacterial burden with colistin Song 2009 [] In-vivo randomized (neutropenic mice with pneumonia following tracheal A. baumannii inoculation) Imipenem A. baumannii, 1 clinical CR isolate OXA-51 positive. Imipenem MIC 64, colistin ≤0.5 Lung bacterial loads at 48h Bacteremia eradication at 48h Mortality at 48h Combi 7.15 ± 3.56 vs. Colistin alone 6.35 ± 0.98 Combi 0/3 vs. Colistin alone 0/3 Combi 1/3 vs. Colistin alone 1/3 In-vivo bacterial load, bacteremia and mortality
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