CpG mutations: Mismatch, but the wrong base cannot be identified. CpG mutations: Genome Evolution Genome Evolution CpG mutations rate: Substitution rate on CpG dinucleotides is about – 15x higher than for or ordinary C’s G’s. Genome Evolution CpG mutations rate Methylated cytosines causes a high – –Conclusion: mutation rate. Worked as a fuel for genome evolution LESSON 168 Genome Evolution Indels: When the ancestral sequence is not known, insertions and deletions cannot be distinguished, then referred to as When one cannot infer the phylogenetic “indels”. direction of the sequence change, the sequence change event is referred to as an "indel". A microindel is defined as an indel that results in a net change of 1 to 50 nucleotides. In coding
CpG mutations: Mismatch, but the wrong base cannot be identified. CpG mutations: Genome Evolution Genome Evolution – CpG mutations rate: Substitution rate on CpG dinucleotides is about 15x higher than for ordinary C’s or G’s. Genome Evolution – CpG mutations rate –Conclusion: Methylated cytosines causes a high mutation rate. Worked as a fuel for genome evolution LESSON 168 Genome Evolution Indels: When the ancestral sequence is not known, insertions and deletions cannot be distinguished, then referred to as “indels”. When one cannot infer the phylogenetic direction of the sequence change, the sequence change event is referred to as an "indel". A microindel is defined as an indel that results in a net change of 1 to 50 nucleotides. In coding
Handouts%20Genomics.docx