Table Summary of published economic evaluation of MTA, RFA, surgery and RT to treat lung cancer Time Country and Intervention Comparator Reference Horizon Population Cost Costs Type of analysis Perspective Results Sher et al. A lifetime 65-year-old men with RFA treatment SBRT cost of Markov model Payer SBRT had an ICER of $6,000/QALY compared to () horizon medically inoperable for eradiation of $14,741.13 comparing RFA, 3DCRT and $14,100/QALY for SBRT relative to NSCLC in USA pulmonary includes SBRT and 3DCRT RFA. tumour and simulation, guidance cost of planning and $5,879.62 treatment Alexander 9 years 84 patients older than Median cost per Median cost of Patient health Payer RFA patients were calculated to have a cost per et al () 65 years of age with month lived was $1,195.92 per histories and billing month of life of $620.74, compared to $1,195.92 for stage IA or IB $620.74 for RFA month for a patient charges converted to surgery lung cancer in treated surgically 2009 Medicare the USA reimbursement fees. Kwan et al 2 years Matched cohort of 128 Ablation had a Surgery had a Compared medical Payer Thermal ablation had lower treatment and medical () patients of at least 65 mean cost of mean cost of costs for a costs at 1 month, 3 months, and 12 months relative years of age with stage $50,682 over 24 $57,994 over 24 cohort of to sub-lobar resection IA/IB NSCLC in USA months months Medicare patients. Grutters et 5-year Inoperable and operable Carbon-ion and CRT and SBRT Decision-analytic Health Carbon-ion therapy costed €67.257 per al () stage I NSCLC. Model proton therapy Markov model system gained compared to SBRT for based on clinical data inoperable stage I NSCLC. from Japan for operable and Dutch for inoperable patients.
Table Summary of published economic evaluation of MTA, RFA, surgery and RT to treat lung cancer Reference Time Horizon Country and Population Intervention Cost Comparator Costs Type of analysis Perspective Results Sher et al. () A lifetime horizon 65-year-old men with medically inoperable NSCLC in USA RFA treatment for eradiation of pulmonary tumour and guidance cost of $5,879.62 SBRT cost of $14,741.13 includes simulation, planning and treatment Markov model comparing RFA, SBRT and 3DCRT Payer SBRT had an ICER of $6,000/QALY compared to 3DCRT and $14,100/QALY for SBRT relative to RFA. Alexander et al () 9 years 84 patients older than 65 years of age with stage IA or IB lung cancer in the USA Median cost per month lived was $620.74 for RFA Median cost of $1,195.92 per month for a patient treated surgically Patient health histories and billing charges converted to 2009 Medicare reimbursement fees. Payer RFA patients were calculated to have a cost per month of life of $620.74, compared to $1,195.92 for surgery Kwan et al () 2 years Matched cohort of 128 patients of at least 65 years of age with stage IA/IB NSCLC in USA Ablation had a mean cost of $50,682 over 24 months Surgery had a mean cost of $57,994 over 24 months Compared medical costs for a cohort of Medicare patients. Payer Thermal ablation had lower treatment and medical costs at 1 month, 3 months, and 12 months relative to sub-lobar resection Grutters et al () 5-year Inoperable and operable stage I NSCLC. Model based on clinical data from Japan for operable and Dutch for inoperable patients. Carbon-ion and proton therapy CRT and SBRT Decision-analytic Markov model Health system Carbon-ion therapy costed €67.257 per gained compared to SBRT for inoperable stage I NSCLC.
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