Direct dermal exposure Cosmetic products Use C DA Daily Systemic Exposure Amount Product type RF (%) (%) (mg/kg bw/day) (mg/day) Facial cleanser 800 7 0.01 10 0.0009 Shampoo 10,460 7 0.01 10 0.0114 Conditioner 3,920 7 0.01 10 0.0043 Shower gel 18,670 7 0.01 10 0.0204 Hand wash soap 20,000 7 0.01 10 0.0219 Total 0.0589 Daily systemic exposure = (Use amount × C × RF × DA)/BW, where C = use concentration, RF = retention factor, DA = dermal absorption rate, BW = average bodyweight Household cleaning products Daily Contact Product Film Time systemic Frequency C DA Product type Area Use C Scale exposure (use/day) (%) (%) (cm2) (g/cm3) (cm) Factor (mg/kg bw/day) Laundry 1.43 12 1980 0.01 0.01 0.007 10 0.0004 liquid Dishwashing 3 12 1980 0.009 0.01 0.03 10 0.0030 liquid All-purpose 1 12 1980 1 0.01 0.007 10 0.0260 cleaner Total 0.0294 Daily systemic exposure = (frequency × C × contact area × product use C × film thickness × time scale factor × DA)/BW, where C = concentration, DA = dermal absorption rate, BW = average bodyweight Indirect dermal exposure (from wearing clothes) Household cleaning products Daily systemic Amount C PR PT DA Product type exposure (g/use) (%) (%) (%) (%) (mg/kg bw/day) Laundry liquid 230 12 0.95 10 10 0.0410
Direct dermal exposure Cosmetic products Product type Use Amount (mg/day) C (%) RF DA (%) Daily Systemic Exposure (mg/kg bw/day) Facial cleanser 800 7 0.01 10 0.0009 Shampoo 10,460 7 0.01 10 0.0114 Conditioner 3,920 7 0.01 10 0.0043 Shower gel 18,670 7 0.01 10 0.0204 Hand wash soap 20,000 7 0.01 10 0.0219 Total 0.0589 Daily systemic exposure = (Use amount × C × RF × DA)/BW, where C = use concentration, RF = retention factor, DA = dermal absorption rate, BW = average bodyweight Household cleaning products Product type Frequency (use/day) C (%) Contact Area (cm2) Product Use C (g/cm3) Film (cm) Time Scale Factor DA (%) Daily systemic exposure (mg/kg bw/day) Laundry liquid 1.43 12 1980 0.01 0.01 0.007 10 0.0004 Dishwashing liquid 3 12 1980 0.009 0.01 0.03 10 0.0030 All-purpose cleaner 1 12 1980 1 0.01 0.007 10 0.0260 Total 0.0294 Daily systemic exposure = (frequency × C × contact area × product use C × film thickness × time scale factor × DA)/BW, where C = concentration, DA = dermal absorption rate, BW = average bodyweight Indirect dermal exposure (from wearing clothes) Household cleaning products Product type Amount (g/use) C (%) PR (%) PT (%) DA (%) Daily systemic exposure (mg/kg bw/day) Laundry liquid 230 12 0.95 10 10 0.0410
GlucitolSTD735S-FINAL-06-2017.docx