Erce & Parks 8 primary studies Cryoablation, RFA, HCC and CRC tumours At this time, MTA of liver had primarily been used to treat HCC. Complete necrosis is 2003 on HCC and MTA, ILP, ethanol possible in tumours <2cm. Recurrence was low. secondary tumours ablation, other SR injections UK Garcea et al. 2 primary studies Ten types of ablation Primary and secondary Studies on treatment of secondary and primary cancer with PEI, percutaneous acetic acid 2003 on primary and tumours injection, other percutaneous injections, RFA, high-intensity focused ultrasound (HIFU), secondary tumours interstitial laser photocoagulation (ILP), MTA, electrolysis and cryotherapy. Two studies SR reported on MTA use in the liver. Fair therapeutic results were achieved with MTA in lesions of 30 mm or less, and in well differentiated HCCs. UK HCC = hepatocellular carcinoma; HIFU = high-intensity focused ultrasound; ILP = interstitial laser photocoagulation; MHz = Megahertz; MTA = microwave tissue ablation; PEI = percutaneous ethanol injection; RFA = radiofrequency ablation; SR = systematic review; UK = United Kingdom; USA = United States of America Table 3 Included systematic reviews on primary liver cancer Study ID Evidence level of Interventions Population Key outcomes included studies Study type Location Weiss et al. 1 level II study on RFA, resection*, PEI, HCC Included one RCT on RFA versus microwave ablation (one trial, 72 participants). No 2013 HCC laser ablation and significant difference was found between RFA and percutaneous MTA regarding local MTA progression. Rate of complications in both groups was low. SR Germany *Included Shibata et al. 2002 only; HCC = hepatocellular carcinoma; ILP = interstitial laser photocoagulation; MTA = microwave tissue ablation; PEI = percutaneous ethanol injection; RCT = randomised controlled trial; RFA = radiofrequency ablation; SR = systematic review
Erce & Parks 2003 SR UK 8 primary studies on HCC and secondary tumours Cryoablation, RFA, MTA, ILP, ethanol ablation, other injections HCC and CRC tumours At this time, MTA of liver had primarily been used to treat HCC. Complete necrosis is possible in tumours <2cm. Recurrence was low. Garcea et al. 2003 SR UK 2 primary studies on primary and secondary tumours Ten types of ablation Primary and secondary tumours Studies on treatment of secondary and primary cancer with PEI, percutaneous acetic acid injection, other percutaneous injections, RFA, high-intensity focused ultrasound (HIFU), interstitial laser photocoagulation (ILP), MTA, electrolysis and cryotherapy. Two studies reported on MTA use in the liver. Fair therapeutic results were achieved with MTA in lesions of 30 mm or less, and in well differentiated HCCs. HCC = hepatocellular carcinoma; HIFU = high-intensity focused ultrasound; ILP = interstitial laser photocoagulation; MHz = Megahertz; MTA = microwave tissue ablation; PEI = percutaneous ethanol injection; RFA = radiofrequency ablation; SR = systematic review; UK = United Kingdom; USA = United States of America Table 3 Included systematic reviews on primary liver cancer Study ID Study type Location Evidence level of included studies Interventions Population Key outcomes Weiss et al. 2013 SR Germany 1 level II study on HCC RFA, resection*, PEI, laser ablation and MTA HCC Included one RCT on RFA versus microwave ablation (one trial, 72 participants). No significant difference was found between RFA and percutaneous MTA regarding local progression. Rate of complications in both groups was low. *Included Shibata et al. 2002 only; HCC = hepatocellular carcinoma; ILP = interstitial laser photocoagulation; MTA = microwave tissue ablation; PEI = percutaneous ethanol injection; RCT = randomised controlled trial; RFA = radiofrequency ablation; SR = systematic review
1402_FinalProtocol.docx