Table 9 Summary of PICO to define research question Health care Outcomes to Population Intervention Comparator resources to be be assessed considered Patients at high TAVI Standard AVR Improvement in Cost of – risk for operative transfemoral overall survival. intervention and mortality & Impact on comparator. percutaneous quality of life Cost of peripheral management of access is adverse events. available Cost of follow-up management. Patients who are TAVI Medical Improvement in Cost of – non-operable transaortic / management ± overall survival. intervention and but do not have transapical / balloon Impact on comparator. a short life sub-clavian valvuloplasty quality of life Cost of expectancy & management of percutaneous adverse events. peripheral Cost of follow-up access is management. available Patients at high TAVI - Standard AVR Improvement in Cost of risk for operative transfemoral overall survival. intervention and mortality & Impact on comparator. percutaneous quality of life Cost of peripheral management of access is NOT adverse events. available Cost of up management. Patients who are TAVI - Medical Improvement in Cost of non-operable transaortic / management ± overall survival. intervention and but do not have transapical / balloon Impact on comparator. a short life sub-clavian valvuloplasty quality of life Cost of expectancy & management of percutaneous adverse events. peripheral Cost of access is NOT available management.
Table 9 Summary of PICO to define research question Population Intervention Comparator Outcomes to be assessed Health care resources to be considered Patients at high risk for operative mortality & percutaneous peripheral access is available TAVI – transfemoral Standard AVR Improvement in overall survival. Impact on quality of life Cost of intervention and comparator. Cost of management of adverse events. Cost of follow-up management. Patients who are non-operable but do not have a short life expectancy & percutaneous peripheral access is available TAVI – transaortic / transapical / sub-clavian Medical management ± balloon valvuloplasty Improvement in overall survival. Impact on quality of life Cost of intervention and comparator. Cost of management of adverse events. Cost of follow-up management. Patients at high risk for operative mortality & percutaneous peripheral access is NOT available TAVI - transfemoral Standard AVR Improvement in overall survival. Impact on quality of life Cost of intervention and comparator. Cost of management of adverse events. Cost of management. Patients who are non-operable but do not have a short life expectancy & percutaneous peripheral access is NOT available TAVI - transaortic / transapical / sub-clavian Medical management ± balloon valvuloplasty Improvement in overall survival. Impact on quality of life Cost of intervention and comparator. Cost of management of adverse events. Cost of management. up
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