Table Ongoing clinical trials Study identifier, Title Inclusion Sponsor Target Time Status Finish Study type population, sample frame date country size Can 3-Tesla Magnetic Men with a high or The Wesley 225 NR Recruiting NR III-3, Resonance imaging of the concerning PSA, or Hospital diagnostic prostate be useful in abnormal prostatic rectal case-control Population 1 making the decision to examination study Australia perform prostate biopsy in men with a high or concerning PSA? NCT01492270 PICTURE - Prostate Men who have undergone University NR 1.5 years Unknown NR III-3, Imaging (Multi-parametric prior trans-rectal biopsies College London – status diagnostic Population 1 MRI and Prostate and are undergoing has not case-control Hospitals UK HistoScanning™) further evaluation for been study Compared to characterisation. verified in Ultrasound more than Guided Biopsy for two years Significant Prostate Cancer Risk Evaluation. NCT02526797 Multiparametric MRI in Men with low risk localized Herlev Hospital 150 3 months Enrolling June 2015 III-3, Men With Prostate Cancer PCa enrolled in active by diagnostic Population 2 Undergoing Active case-control surveillance invitation Denmark Surveillance study NCT02485379 Improvement in the Men referred for prostate Hospices Civils 250 1 – 4 Recruiting October III-3, Detection of Aggressive mpMRI before a first set of de Lyon months 2916 diagnostic Population 1 Prostate Cancer by prostate biopsies, with a case-control France Targeted Biopsies Using planned time interval of study Multiparametric MRI less than 3 months Findings NCT02564549 Multiparametric Gleason score ≤ 6 Virginia 192 3 years Recruiting October III-2 Active Surveillance Commonwealth 2017 Population 2 to Avoid the Risks of University, USA Serial Biopsies in Men Massey Cancer With Low-Risk Prostate Center, Hunter
Table Ongoing clinical trials Study identifier, population, country Title Inclusion Sponsor Target sample size Time frame Status Finish date Study type Population 1 Australia Can 3-Tesla Magnetic Resonance imaging of the prostate be useful in making the decision to perform prostate biopsy in men with a high or concerning PSA? Men with a high or concerning PSA, or abnormal prostatic rectal examination The Wesley Hospital 225 NR Recruiting NR III-3, diagnostic case-control study NCT01492270 Population 1 UK PICTURE - Prostate Imaging (Multi-parametric MRI and Prostate HistoScanning™) Compared to Ultrasound Guided Biopsy for Significant Prostate Cancer Risk Evaluation. Men who have undergone prior trans-rectal biopsies and are undergoing further evaluation for characterisation. University College London Hospitals NR 1.5 years Unknown – status has not been verified in more than two years NR III-3, diagnostic case-control study NCT02526797 Population 2 Denmark Multiparametric MRI in Men With Prostate Cancer Undergoing Active Surveillance Men with low risk localized PCa enrolled in active surveillance Herlev Hospital 150 3 months Enrolling by invitation June 2015 III-3, diagnostic case-control study NCT02485379 Population 1 France Improvement in the Detection of Aggressive Prostate Cancer by Targeted Biopsies Using Multiparametric MRI Findings Men referred for prostate mpMRI before a first set of prostate biopsies, with a planned time interval of less than 3 months Hospices Civils de Lyon 250 1 – 4 months Recruiting October 2916 III-3, diagnostic case-control study NCT02564549 Population 2 USA Multiparametric Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk Prostate Gleason score ≤ 6 Virginia Commonwealth University, Massey Cancer Center, Hunter 192 3 years Recruiting October 2017 III-2
1397_Final_MSAC_Assessment_Report.docx