•A generator is constructed on the principle of the decay-growth relationship between a long-lived parent radionuclide and its short-lived daughter radionuclide. •The chemical property of the daughter nuclide must be distinctly different from that of the parent nuclide so that the former can be readily separated Principles of a Generator •In a generator, basically a long-lived parent nuclide is allowed to decay to its short-lived daughter nuclide and the latter is then chemically separated. importance of radionuclide generators lies in the fact that they are 1.Easily transportable 2.Serve as sources of short-lived radionuclides in institutions far from the site of a cyclotron or reactor facility History •The first commercial radionuclide generator was the 132Te (t1/2=78 (t1/2=2.3 hr) in the early 1960s. •Since then, a number of other generator systems have been developed and tried for routine use in nuclear medicine. •Only a few of these generators are of importance in nuclear medicine. –They are the 99Mo–99mTc, 113Sn–113m In, 82Sr–82Rb, and systems. Structure and Mechanism •consists of a glass or plastic column fitted at the bottom with a fritted disk. •The column is filled with adsorbent material such as cation- or resin, alumina, and zirconia, on which the parent nuclide is adsorbed. •The daughter radionuclide grows as a result of the decay of the parent until either a transient or a secular equilibrium is reached within several half-lives of the daughter
•A generator is constructed on the principle of the decay-growth relationship between a long-lived parent radionuclide and its short-lived daughter radionuclide. •The chemical property of the daughter nuclide must be distinctly different from that of the parent nuclide so that the former can be readily separated Principles of a Generator •In a generator, basically a long-lived parent nuclide is allowed to decay to its short-lived daughter nuclide and the latter is then chemically separated. importance of radionuclide generators lies in the fact that they are 1.Easily transportable 2.Serve as sources of short-lived radionuclides in institutions far from the site of a cyclotron or reactor facility History •The first commercial radionuclide generator was the 132Te (t1/2=78 (t1/2=2.3 hr) in the early 1960s. •Since then, a number of other generator systems have been developed and tried for routine use in nuclear medicine. •Only a few of these generators are of importance in nuclear medicine. –They are the 99Mo–99mTc, 113Sn–113m In, 82Sr–82Rb, and systems. Structure and Mechanism •consists of a glass or plastic column fitted at the bottom with a fritted disk. •The column is filled with adsorbent material such as cation- or resin, alumina, and zirconia, on which the parent nuclide is adsorbed. •The daughter radionuclide grows as a result of the decay of the parent until either a transient or a secular equilibrium is reached within several half-lives of the daughter
handout_-nuclear_pharmacy.docx