116) patient/cycle proportion of clinic first line patients EGFR WT estimated from Lux Lung 3 trial Cost of chemotherapy (1 PBS item day 1 unit / Estimate 265.32 x 45mg carboplatin) treatment EGFR WT number of (PBS cost per maximum facility, patient / cycles form quantity) private or cycle Lux Lung 3 public trial hospital outpatient clinic Cost of chemotherapy (1 PBS item day 1 unit / Estimate x 3000mg gemcitabine) treatment EGFR WT number of (PBS cost per maximum facility, patient / cycles form quantity) private or cycle Lux Lung 3 public trial hospital outpatient clinic Drug administration cost Day patient Once every $62.60 for <1 hour infusion 3 weeks. (MBS item 13915) No. of infusions per patient TBD Public hospital outpatient Out-patient ~86% Once every $560.00 admission for (EGFR 3 weeks. administration negative No. of pts) infusions per patient TBD Full day hospital Day patient ~86% Once every $562.00 admission for (EGFR 3 weeks. chemotherapy negative No. of administration in a public pts) infusions per hospital setting patient TBD (excluding average pharmacy component) Full day hospital Day patient ~86% Once every $331.00 admission for (EGFR 3 weeks. chemotherapy negative No. of administration in a pts) infusions per private hospital setting patient TBD Follow up consultation Medical Private 1 unit/2 Estimate monitoring disease and oncologist rooms or from Lux treatment (MBS item) inpatient/ R mutation Lung 3 trial outpatient positive clinic patient Resources provided in association with proposed intervention Management of side effects of afatinib Management of side effects of chemotherapy Resources provided to deliver the comparator to the current intervention (from Step 4, e.g., pre-treatments, co-administered interventions). Identify variations where there may be more than one comparator or where these may vary across different decision
116) clinic patient/cycle proportion of first line patients EGFR WT estimated from Lux Lung 3 trial Cost of chemotherapy (1 x 45mg carboplatin) (PBS cost per maximum quantity) PBS item day treatment facility, private or public hospital outpatient clinic 1 unit / EGFR WT patient / cycle Estimate number of cycles form Lux Lung 3 trial 265.32 Cost of chemotherapy (1 x 3000mg gemcitabine) (PBS cost per maximum quantity) PBS item day treatment facility, private or public hospital outpatient clinic 1 unit / EGFR WT patient / cycle Estimate number of cycles form Lux Lung 3 trial Drug administration cost for <1 hour infusion (MBS item 13915) Day patient Once every 3 weeks. No. of infusions per patient TBD $62.60 Public hospital outpatient admission for administration Out-patient ~86% (EGFR negative pts) Once every 3 weeks. No. of infusions per patient TBD $560.00 Full day hospital admission for chemotherapy administration in a public hospital setting (excluding average pharmacy component) Day patient ~86% (EGFR negative pts) Once every 3 weeks. No. of infusions per patient TBD $562.00 Full day hospital admission for chemotherapy administration in a private hospital setting Day patient ~86% (EGFR negative pts) Once every 3 weeks. No. of infusions per patient TBD $331.00 Follow up consultation monitoring disease and treatment (MBS item) Medical oncologist Private rooms or inpatient/ outpatient clinic 1 unit/2 mutation positive patient Estimate from Lux Lung 3 trial Resources provided in association with proposed intervention Management of side effects of afatinib Management of side effects of chemotherapy Resources provided to deliver the comparator to the current intervention (from Step 4, e.g., pre-treatments, co-administered interventions). Identify variations where there may be more than one comparator or where these may vary across different decision R
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