6. Did participants enter the study at a similar point in the disease? 7. Was the clearly described in the study? 8. Were additional interventions (co-interventions) clearly reported in the study? 9. Are the outcome measures clearly defined in the introduction or methods section? (30-day mortality) 10. Were relevant outcomes appropriately measured with objective and/or subjective methods? (30-day mortality) 11. Were outcomes measured before and after intervention? (30-day mortality) 12. Were the statistical tests used to assess the relevant outcomes appropriate? 13. Was the length of follow-up reported? 14. Was the loss to follow-up reported? 15. Does the study provide estimates of the random variability in the data analysis of relevant outcomes? 16. Are adverse events reported? (30-day follow-up) 17. Are the conclusions of the study supported by results? 18. Are both competing interest and source of support for the study reported? 19. Have the authors taken account of potential confounding factors in the design or analyses? 20. Are results adjusted for confounding? 21. Has adjustment made a big difference? Table S4 Thirty-day mortality or peri-operative mortality in comparative studies Unadjusted Unadjusted Unadjusted Adjusted Adjusted Method of adjustment Endpoint in
6. Did participants enter the study at a similar point in the disease? 7. Was the clearly described in the study? 8. Were additional interventions (co-interventions) clearly reported in the study? 9. Are the outcome measures clearly defined in the introduction or methods section? (30-day mortality) 10. Were relevant outcomes appropriately measured with objective and/or subjective methods? (30-day mortality) 11. Were outcomes measured before and after intervention? (30-day mortality) 12. Were the statistical tests used to assess the relevant outcomes appropriate? 13. Was the length of follow-up reported? 14. Was the loss to follow-up reported? 15. Does the study provide estimates of the random variability in the data analysis of relevant outcomes? 16. Are adverse events reported? (30-day follow-up) 17. Are the conclusions of the study supported by results? 18. Are both competing interest and source of support for the study reported? 19. Have the authors taken account of potential confounding factors in the design or analyses? 20. Are results adjusted for confounding? 21. Has adjustment made a big difference? Table S4 Thirty-day mortality or peri-operative mortality in comparative studies Unadjusted Unadjusted Unadjusted Adjusted Adjusted Method of adjustment Endpoint in
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