gap genes begin to divide embryo into regions (knirps or kruppel) pair rule genes establish homeotic genes specify segment segments(ftz or eve) identity (antp or btx) segment polarity genes define A-P within segment and reinforce segment boundaries(wg or en) B. You find a mutation in a gene that you call antenna-leg, in which the animal has antennae growing where legs should be. What class of genes is antenna-leg likely to belong to (4 points)? looks like a homeotic mutation 7. In C. elegans, cell-cell signaling specifies vulval cell fates, causing the Pn.p cells to adopt primary, secondary or tertiary fates. Give the predicted effect of the following mutations in each of the cell fates listed (i.e. increase, decrease or no change, 2 pts each, 10 pts total): primary rationale A. loss of EGFR (let-23) decrease to Can’t activate kinases inhibit transcription factors B. gain-of-function (kinase increase mpk-1 downstream of Ras) loss of EGF plus C. increase activating mutation in Ras D. transcription factors (lin-1 or decrease lin-31) that be inactivated can’t E. loss of transcription factors increase plus loss of Ras 8. Robinow Syndrome is found in different forms, which show different modes of transmission. The pedigree below shows the transmission of one form of the disease. Affected individuals show the trait from birth. A. What mode of inheritance does this form of Robinow Syndrome show (4 points)? Autosomal recessive
gap genes begin to divide embryo into regions (knirps or kruppel) pair rule genes establish homeotic genes specify segment segments(ftz or eve) identity (antp or btx) segment polarity genes define A-P within segment and reinforce segment boundaries(wg or en) B. You find a mutation in a gene that you call antenna-leg, in which the animal has antennae growing where legs should be. What class of genes is antenna-leg likely to belong to (4 points)? looks like a homeotic mutation 7. In C. elegans, cell-cell signaling specifies vulval cell fates, causing the Pn.p cells to adopt primary, secondary or tertiary fates. Give the predicted effect of the following mutations in each of the cell fates listed (i.e. increase, decrease or no change, 2 pts each, 10 pts total): primary rationale A. loss of EGFR (let-23) decrease Can’t activate kinases to inhibit transcription factors B. gain-of-function mpk-1 (kinase increase downstream of Ras) C. loss of EGF plus increase activating mutation in Ras D. transcription factors (lin-1 or lin-31) decrease that can’t be inactivated E. loss of transcription factors increase plus loss of Ras 8. Robinow Syndrome is found in different forms, which show different modes of transmission. The pedigree below shows the transmission of one form of the disease. Affected individuals show the trait from birth. A. What mode of inheritance does this form of Robinow Syndrome show (4 points)? Autosomal recessive
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