Nour-eldin et al Retrospective CS Patients with primary NSCLC or secondary lung tumours Intervention: CT-guided 1. Pneumothorax: categorised as mild, moderate or severe (2011) deemed medically inoperable or where the patient had MTA or RFA Level IV refused surgery. Patients with metastatic lung tumours were Germany Conscious sedation Risk of bias: High without evidence of extrapulmonary metastases Duration: NR Hospital setting N = 164 (NR, 248 ablation sessions) Comparator: N/A NR Tumour size: NR M/F ratio: 92:72 Mean (SD) age: 59.7 (9.8) years 20/248 (8.1%) of ablation sessions were for primary lesions, 228/248 (91.9%) were for metastatic lesions Sun et al (2014) Retrospective CS Patients with primary or metastatic lung cancer, primary Intervention: CT-guided 1. Adverse events: any associated symptoms occurring cancers included stage I-IV lung cancer. Distant metastases MTA within 30 days following ablation were considered China Level IV of patients with stage IV cancer and primary tumours of complications Conscious sedation Hospital setting patients with pulmonary metastases had achieved complete Duration: mean (range): 8 25 (3–45) months response or stable disease following prior therapy (5–12) minutes N = 29 (39) Comparator: N/A Tumour size - mean (range): 37 (15–58) mm M/F ratio: 12:12 Median (range) age: 63 (39–74) years Primary NSCLC patients: 7/15 (46.7%) stage I, 2/15 (13.3%) stage II, 4/15 (26.7%) stage III, 2/15 (13.3%) stage IV. Metastases patients: 8/14 (57.1%) intestinal adenocarcinoma, 4/14 (28.6%) liver cancer, 2/14 (14.3%) breast cancer.
Nour-eldin et al (2011) Germany Retrospective CS Level IV Risk of bias: High Hospital setting NR Patients with primary NSCLC or secondary lung tumours deemed medically inoperable or where the patient had refused surgery. Patients with metastatic lung tumours were without evidence of extrapulmonary metastases N = 164 (NR, 248 ablation sessions) Tumour size: NR M/F ratio: 92:72 Mean (SD) age: 59.7 (9.8) years 20/248 (8.1%) of ablation sessions were for primary lesions, 228/248 (91.9%) were for metastatic lesions Intervention: CT-guided MTA or RFA Conscious sedation Duration: NR Comparator: N/A 1. Pneumothorax: categorised as mild, moderate or severe Sun et al (2014) China Retrospective CS Level IV Hospital setting 25 (3–45) months Patients with primary or metastatic lung cancer, primary cancers included stage I-IV lung cancer. Distant metastases of patients with stage IV cancer and primary tumours of patients with pulmonary metastases had achieved complete response or stable disease following prior therapy N = 29 (39) Tumour size - mean (range): 37 (15–58) mm M/F ratio: 12:12 Median (range) age: 63 (39–74) years Primary NSCLC patients: 7/15 (46.7%) stage I, 2/15 (13.3%) stage II, 4/15 (26.7%) stage III, 2/15 (13.3%) stage IV. Metastases patients: 8/14 (57.1%) intestinal adenocarcinoma, 4/14 (28.6%) liver cancer, 2/14 (14.3%) breast cancer. Intervention: CT-guided MTA Conscious sedation Duration: mean (range): 8 (5–12) minutes Comparator: N/A 1. Adverse events: any associated symptoms occurring within 30 days following ablation were considered complications
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