TRUSGB Table Studies rpeorting safety outcomes associated with TRUSGB Used in Level of Study ID Study type Location Study population characteristics Description of Relevant outcomes assessed evidencec Enrolmenta Setting n Biopsy type (i.e. related to outcomes specified in PICO) Designb Age years Cores PSA ng/ml Enema (%) PSA density Needle thickness Prior biopsy (%) Anastasiadis et al. No Case series IV UK n: 198,361 TRUSGB UTI (2015) Non-consecutive Multiple Age: Cores: 10-12 Urinary obstruction hospitals Prospective 45-54: 3.2% Enema: NR Haematuria 55-64: 21.5% Needle: NR Hospitalisation 65-74: 40.5% 75-84: 28.9% ≥85: 5.9% PSA: NR Prior biopsy: NR Carignan et al. No Case-control III-2 Canada n: 5,798 TRUSGB Major infection (2012) Consecutive Tertiary Age: 66.7 [61.8-72.0] Cores: 12 UTI hospital Retrospective PSA: NR Enema: 28 Hospitalisation Prior biopsy: NR Needle: NR Bacteraemia Nam et al. (2013) No Case series IV Canada n: 75,190 TRUSGB Minor infection Non-consecutive Multiple Age: Cores: NR Urinary obstruction hospitals Retrospective <50=3.1 Enema: NR Hospitalisation 51-59=21.1 Needle: NR bleeding 70-79=41.6 ≥80=4.7 PSA: NR Prior biopsy: 0
TRUSGB Table Studies rpeorting safety outcomes associated with TRUSGB Study ID Used in Study type Enrolmenta Designb Level of evidencec Location Setting Study population characteristics n Age years PSA ng/ml PSA density Prior biopsy (%) Description of Biopsy type Cores Enema (%) Needle thickness Relevant outcomes assessed (i.e. related to outcomes specified in PICO) Anastasiadis et al. (2015) No Case series Non-consecutive Prospective IV UK Multiple hospitals n: 198,361 Age: 45-54: 3.2% 55-64: 21.5% 65-74: 40.5% 75-84: 28.9% ≥85: 5.9% PSA: NR Prior biopsy: NR TRUSGB Cores: 10-12 Enema: NR Needle: NR UTI Urinary obstruction Haematuria Hospitalisation Carignan et al. (2012) No Case-control Consecutive Retrospective III-2 Canada Tertiary hospital n: 5,798 Age: 66.7 [61.8-72.0] PSA: NR Prior biopsy: NR TRUSGB Cores: 12 Enema: 28 Needle: NR Major infection UTI Hospitalisation Bacteraemia Nam et al. (2013) No Case series Non-consecutive Retrospective IV Canada Multiple hospitals n: 75,190 Age: <50=3.1 51-59=21.1 70-79=41.6 ≥80=4.7 PSA: NR Prior biopsy: 0 TRUSGB Cores: NR Enema: NR Needle: NR Minor infection Urinary obstruction Hospitalisation bleeding
1397_Final_MSAC_Assessment_Report.docx