Positive 14,413 patients not not serious serious1 not serious none One study reported Important ⨁⨀⨀⨀ surgical serious a delay >9 months VERY LOW (6 studies). margins was associated with an increase in the rate of positive surgical margins in patients with intermediate risk disease. 8 studies reported no impact from delayed treatment a: GRADE Working Group grades of evidence () High quality: We are very confident that the true effect lies close to that of the estimate of effect. ⨁⨁⨁⨁ Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. ⨁⨁⨁⨀ Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. ⨁⨁⨀⨀ Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. ⨁⨀⨀⨀ 1: Indirectness was rated serious: this was due to the delay in the included studies being shorted than what would likely be experienced by patients in our population. 2: Noting the small number of included studies; however both studies had >300 patients. 3: Noting the small number of included studies; however median sample size was >300 patients. QoE = quality of evidence.
Positive surgical margins 14,413 patients (6 studies). not serious not serious serious1 not serious none One study reported a delay >9 months was associated with an increase in the rate of positive surgical margins in patients with intermediate risk disease. 8 studies reported no impact from delayed treatment ⨁⨀⨀⨀ VERY LOW Important a: GRADE Working Group grades of evidence () ⨁⨁⨁⨁ High quality: We are very confident that the true effect lies close to that of the estimate of effect. ⨁⨁⨁⨀ Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. ⨁⨁⨀⨀ Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. ⨁⨀⨀⨀ Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. 1: Indirectness was rated serious: this was due to the delay in the included studies being shorted than what would likely be experienced by patients in our population. 2: Noting the small number of included studies; however both studies had >300 patients. 3: Noting the small number of included studies; however median sample size was >300 patients. QoE = quality of evidence.
1397_Final_MSAC_Assessment_Report.docx