Figure 1C: The S1 and S1 sub fragments of the HMM fragment. Source: (Lodish, et al.), labels edited for paper. As seen in Figure 2, many different myosin’s cluster together to form a bipolar filament. Figure 2: Myosin proteins together to form a “bipolar” filament with head domains together and both ends. Source: Actin assembles into a polymer, F-actin that is made up of many linear G-actin monomers, can be seen in Figure 3 below. Actin has functionally distinct ends, (+) end and (-) end. The difference in the ends of actin is that actin monomers favor the addition to the (+) end over the (-) end. Cross-Bridge Cycle: When no ATP is present, the myosin head is tightly bound to actin. When one ATP molecule binds to the myosin head domain, the myosin loses affinity for actin, thus myosin and actin are no longer bound. The myosin head then hydrolyzes the ATP to ADP and Pi, which rotates the myosin head into a “cocked state.” In this cocked state, the myosin head stores the energy released during ATP hydrolysis. Also in this cocked
Figure 1C: The S1 and S1 sub fragments of the HMM fragment. Source: (Lodish, et al.), labels edited for paper. As seen in Figure 2, many different myosin’s cluster together to form a bipolar filament. Figure 2: Myosin proteins together to form a “bipolar” filament with head domains together and both ends. Source: Actin assembles into a polymer, F-actin that is made up of many linear G-actin monomers, can be seen in Figure 3 below. Actin has functionally distinct ends, (+) end and (-) end. The difference in the ends of actin is that actin monomers favor the addition to the (+) end over the (-) end. Cross-Bridge Cycle: When no ATP is present, the myosin head is tightly bound to actin. When one ATP molecule binds to the myosin head domain, the myosin loses affinity for actin, thus myosin and actin are no longer bound. The myosin head then hydrolyzes the ATP to ADP and Pi, which rotates the myosin head into a “cocked state.” In this cocked state, the myosin head stores the energy released during ATP hydrolysis. Also in this cocked
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