Santiago Retrospective review of Paediatric malignancy Initial diagnosis EEO provided by one or more Initial Diagnostic accuracy (agreement, 2013 international paediatric cases histopathology cases pathologists (a board-certified diagnosis minor disagreement, major from low- to middle-income anatomic pathologist, a disagreement) N=705 countries submitted to an haematopathologist, and/or a Diagnostic accuracy by anatomic International Outreach Program neuropathologist) from the site for histopathologic EEO during Department of Pathology at St. Characteristics of cases sent for a 3-year period from 2009 to Jude Children’s Research review 2011. Excluded cases when Hospital. EEO requested by 184 Nature of IHC used by initial EEO was not definitively pathologists from 37 countries pathologist and EEO pathologist conclusive, insufficient tissue (International Outreach Program Correlation between major quality or quantity for diagnosis, partner sites). disagreements and use of IHC or when original primary diagnostic report not available. Low- to middle-income countries obtaining EEO from United States Zembowicz Review of dermatopathology Dermatopathology Initial diagnosis or EEO provided by a consultant Initial Turnaround time 2011 cases received for SO cases no diagnosis pathologist at a free-standing diagnosis Diagnostic categories of consultation from within the rendered clinical laboratory with no formal N=1229 cases specimens submitted for review United States during a 6-month affiliations with large medical (average case period from February to August, institutions. EEO requested by consisted of 3.4 ± 3 2009. pathologists or clinicians due to slides) diagnostic challenges or specific United States policies at outside institutions requiring external second opinion. Abbreviations: EEO, external expert opinion; IHC, immunohistochemistry; SO, second opinion.
Santiago 2013 Retrospective review of international paediatric cases from low- to middle-income countries submitted to an International Outreach Program for histopathologic EEO during a 3-year period from 2009 to 2011. Excluded cases when EEO was not definitively conclusive, insufficient tissue quality or quantity for diagnosis, or when original primary diagnostic report not available. Low- to middle-income countries obtaining EEO from United States Paediatric malignancy histopathology cases N=705 Initial diagnosis EEO provided by one or more pathologists (a board-certified anatomic pathologist, a haematopathologist, and/or a neuropathologist) from the Department of Pathology at St. Jude Children’s Research Hospital. EEO requested by 184 pathologists from 37 countries (International Outreach Program partner sites). Initial diagnosis Diagnostic accuracy (agreement, minor disagreement, major disagreement) Diagnostic accuracy by anatomic site Characteristics of cases sent for review Nature of IHC used by initial pathologist and EEO pathologist Correlation between major disagreements and use of IHC Zembowicz 2011 Review of dermatopathology cases received for SO consultation from within the United States during a 6-month period from February to August, 2009. United States Dermatopathology cases N=1229 cases (average case consisted of 3.4 ± 3 slides) Initial diagnosis or no diagnosis rendered EEO provided by a consultant pathologist at a free-standing clinical laboratory with no formal affiliations with large medical institutions. EEO requested by pathologists or clinicians due to diagnostic challenges or specific policies at outside institutions requiring external second opinion. Initial diagnosis Turnaround time Diagnostic categories of specimens submitted for review Abbreviations: EEO, external expert opinion; IHC, immunohistochemistry; SO, second opinion.
1332%20-%20FinalAssessmentReport%20-accessible.docx