(ref. std. = EMB) True N=44 patients Not serious Serious a Not serious Serious b None 263–395 Low positives K=3 studies (QUADAS-2 ⨁⨁⨀⨀ Cross-sectional low risk of (cohort-type accuracy study) bias) False 59–191 negatives True N=53 patients Not serious Serious a Not serious Serious b None 180–273 Low negatives K=3 studies (QUADAS-2 ⨁⨁⨀⨀ Cross-sectional low risk of (cohort-type accuracy study) bias) False 273–366 positives a An imperfect reference standard was used. b The confidence intervals of the sensitivity and/or specificity were (too) large. DCM = dilated cardiomyopathy; EMB = endomyocardial biopsy; HF = heart failure; ICA = invasive coronary angiography; LGE-CMR = late gadolinium enhancement cardiac magnetic resonance (imaging); QoE = quality of evidence Table Evidence profile for the SRs investigating the prognostic value of using LGE-CMR to predict health outcomes in patients with DCM Outcome Study Risk of bias Inconsistency Indirectness Imprecision Other Summary of findings Quality of Importance design considerations evidence HRp, ORp (95%CI) All-cause K=4 Not serious Not serious Not serious Serious Confounding ORp = 3.43 (2.26, 5.22), k=5 Low Critical mortality SRs (duplication would suggest (9/9) ⊕⊕⨀⨀ (1 low, 2 HRp = 2.48 [1.78, 3.44] k=3 (level I) of data) spurious effect, moderate, 1 while no effect ORp = 3.27 (1.94, 5.51), k=3 high risk) was observed ORp = 1.71 (0.80, 3.68), k=4 SCD K=2 Not serious Not serious Not serious Very serious None ORp = 3.33 (1.80, 6.17), k=9 Low Critical SRs (duplicated (9/9) ⊕⊕⨀⨀ (1 low, 1 ORp = 2.05 (0.56, 7.50), k=4 (level I) data, wide
(ref. std. = EMB) True positives False negatives N=44 patients K=3 studies Cross-sectional (cohort-type accuracy study) Not serious (QUADAS-2 low risk of bias) Serious a Not serious Serious b None 263–395 59–191 Low ⨁⨁⨀⨀ True negatives False positives N=53 patients K=3 studies Cross-sectional (cohort-type accuracy study) Not serious (QUADAS-2 low risk of bias) Serious a Not serious Serious b None 180–273 273–366 Low ⨁⨁⨀⨀ a An imperfect reference standard was used. b The confidence intervals of the sensitivity and/or specificity were (too) large. DCM = dilated cardiomyopathy; EMB = endomyocardial biopsy; HF = heart failure; ICA = invasive coronary angiography; LGE-CMR = late gadolinium enhancement cardiac magnetic resonance (imaging); QoE = quality of evidence Table Evidence profile for the SRs investigating the prognostic value of using LGE-CMR to predict health outcomes in patients with DCM Outcome Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations Summary of findings HRp, ORp (95%CI) Quality of evidence Importance All-cause mortality K=4 SRs (level I) Not serious (1 low, 2 moderate, 1 high risk) Not serious Not serious Serious (duplication of data) Confounding would suggest spurious effect, while no effect was observed ORp = 3.43 (2.26, 5.22), k=5 HRp = 2.48 [1.78, 3.44] k=3 ORp = 3.27 (1.94, 5.51), k=3 ORp = 1.71 (0.80, 3.68), k=4 Low ⊕⊕⨀⨀ Critical (9/9) SCD K=2 SRs (level I) Not serious (1 low, 1 Not serious Not serious Very serious (duplicated data, wide None ORp = 3.33 (1.80, 6.17), k=9 ORp = 2.05 (0.56, 7.50), k=4 Low ⊕⊕⨀⨀ Critical (9/9)
1393-CMRforDCM.docx