Table 54: Summary statistics of the associated variants before and after adjustment for sex, height and body mass index in the first set of arcOGEN cases. N SNP Cases Definition Controls definition P P_adjusted case/control Hip OA with Hip OA with rs754106 1234/525 4.10 x10-6 5.25 x10-5 superior JSN non-superior JSN Hip OA with Hip OA with rs754106 404/1355 1.05 x10-5 1.75 x10-4 axial/medial JSN non-axial/medial JSN Hip OA with Hip OA with rs73023563 1234/525 2.34 x10-7 1.80 x10-7 superior JSN non-superior JSN Hip OA with Hip OA with rs17050727 1234/525 4.35 x10-5 4.68 x10-5 axial/medial JSN non-axial/medial JSN Hip OA with Hip OA with rs73023563 404/1355 1.74 x10-6 1.14 x10-6 axial/medial JSN non-axial/medial JSN Hip OA with Hip OA with rs6766414 518/1241 2.90 x10-5 3.19 x10-5 hypertrophic response non-hypertrophic response Hip OA with Hip OA with rs61837881 518/1241 1.97 x10-4 2.37 x10-4 hypertrophic response non-hypertrophic response
Table 54: Summary statistics of the associated variants before and after adjustment for sex, height and body mass index in the first set of arcOGEN cases. SNP Cases Definition Controls definition N case/control P P_adjusted rs754106 Hip OA with superior JSN Hip OA with non-superior JSN 1234/525 4.10 x10-6 5.25 x10-5 rs754106 Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 404/1355 1.05 x10-5 1.75 x10-4 rs73023563 Hip OA with superior JSN Hip OA with non-superior JSN 1234/525 2.34 x10-7 1.80 x10-7 rs17050727 Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 1234/525 4.35 x10-5 4.68 x10-5 rs73023563 Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 404/1355 1.74 x10-6 1.14 x10-6 rs6766414 Hip OA with hypertrophic response Hip OA with non-hypertrophic response 518/1241 2.90 x10-5 3.19 x10-5 rs61837881 Hip OA with hypertrophic response Hip OA with non-hypertrophic response 518/1241 1.97 x10-4 2.37 x10-4
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