drugs would adversely affect the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests. Category E includes animals that experience pain & distress related to ACUP activities that are not relieved with timely and appropriate treatments such as anesthetics, analgesics, medications, refinements, monitoring, or euthanasia. Category E also includes animals that are maintained in a morbid state without treatment or relief for a period of time in order to reach a later endpoint. Descriptions of Category E activities must include enough detail for a layperson to recognize the cause of pain or distress and understand the associated scientific justification for allowing that condition. Descriptions of Category E activities that are mandated by federal regulations must provide a full explanation as stated above, and include a reference to the agency and specific mandate that applies. Examples: Toxicological or infectious testing/research that results in persistent, moderate-to-severe clinical alterations; experience of noxious stimulation that an animal cannot avoid or escape; exposure to extreme environmental conditions; induced paralysis of a conscious animal; engineered phenotype that causes unalleviated pain/distress; prey in predator/prey studies; death as an experimental endpoint; clinical disease allowed to progress to moribundity; LD50 studies; etc.
drugs would adversely affect the procedures, results, or interpretation of the teaching, research, experiments, surgery, or tests. Category E includes animals that experience pain & distress related to ACUP activities that are not relieved with timely and appropriate treatments such as anesthetics, analgesics, medications, refinements, monitoring, or euthanasia. Category E also includes animals that are maintained in a morbid state without treatment or relief for a period of time in order to reach a later endpoint. Descriptions of Category E activities must include enough detail for a layperson to recognize the cause of pain or distress and understand the associated scientific justification for allowing that condition. Descriptions of Category E activities that are mandated by federal regulations must provide a full explanation as stated above, and include a reference to the agency and specific mandate that applies. Examples: Toxicological or infectious testing/research that results in persistent, moderate-to-severe clinical alterations; experience of noxious stimulation that an animal cannot avoid or escape; exposure to extreme environmental conditions; induced paralysis of a conscious animal; engineered phenotype that causes unalleviated pain/distress; prey in predator/prey studies; death as an experimental endpoint; clinical disease allowed to progress to moribundity; LD50 studies; etc.
pain_distress_policyguide.docx