2000: growth 4000: growth, chronic nephritis Rats (m), SD, 8/group 0.5 % (~500) Bell et al. 1978 Diet, 21 days 500: liver total lipid & cholesterol BIBRA 1994 Repeated dose studies (dermal) Rabbits 4 mL/kg (~4800) Dow Chemical 1946* Dermal, occlusive 4800: HCT ECB 2000 25 applications/33 days HSDB 2012 Rabbits 0.5, 1, 2, 4 mL/kg Draize et al. 1944; 1948 (~600, 1200, 2400, 4800) Dermal, non-occlusive Lehman 1955 1200 NOAEL 90 days BIBRA 1994 2400: nephritis 4800: lung oedema, chronic nephritis and liver damage Species Doses (mg/kg bw/d) References Route and duration of exposure NOAEL/LOAEL and effects Rabbits 600 Gleiberman et al. 1975* Dermal 600: bilirubin, globulins, ECB 2000 kidney and damage 50 days REACH Dossier Rats 1250 Gleiberman et al. 1975* Dermal 1250: glucose, globulins, ECB 2000 liver weight 50 days REACH Dossier Rats (m) 200, 1250, 2000 Timofievskaya et al. 1976* Dermal 200 NOAEL ECB 2000 3 months 1250: altered kidney function and nervous REACH Dossier system Mice, CD-1, 50/group 0.1 mL/kg NTP 1995 Dermal, non-occlusive 0.1 mL NOAEL 1 year (5 times/week) No effects at the sole dose used Studies on testes and testicular function Rats, SD, 12/group 1400 Foster et al. 1980 Gavage, 4 days 1400 NOAEL Rats, Wistar, 10/group 2 % (~1000) Oishi & Hiraga 1980
2000: growth 4000: growth, chronic nephritis Rats (m), SD, 8/group Diet, 21 days 0.5 % (~500) 500: liver total lipid & cholesterol Bell et al. 1978 BIBRA 1994 Repeated dose studies (dermal) Rabbits Dermal, occlusive 25 applications/33 days 4 mL/kg (~4800) 4800: HCT Dow Chemical 1946* ECB 2000 HSDB 2012 Rabbits Dermal, non-occlusive 90 days 0.5, 1, 2, 4 mL/kg (~600, 1200, 2400, 4800) 1200 NOAEL 2400: nephritis 4800: lung oedema, chronic nephritis and liver damage Draize et al. 1944; 1948 Lehman 1955 BIBRA 1994 Species Route and duration of exposure Doses (mg/kg bw/d) NOAEL/LOAEL and effects References Rabbits Dermal 50 days 600 600: bilirubin, globulins, kidney and damage Gleiberman et al. 1975* ECB 2000 REACH Dossier Rats Dermal 50 days 1250 1250: glucose, globulins, liver weight Gleiberman et al. 1975* ECB 2000 REACH Dossier Rats (m) Dermal 3 months 200, 1250, 2000 200 NOAEL 1250: altered kidney function and nervous system Timofievskaya et al. 1976* ECB 2000 REACH Dossier Mice, CD-1, 50/group Dermal, non-occlusive 1 year (5 times/week) 0.1 mL/kg 0.1 mL NOAEL No effects at the sole dose used NTP 1995 Studies on testes and testicular function Rats, SD, 12/group Gavage, 4 days 1400 1400 NOAEL Foster et al. 1980 Rats, Wistar, 10/group 2 % (~1000) Oishi & Hiraga 1980
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