Table 5: Results of repeated inhalation study with potassium amyl xanthate in laboratory animals28 Dogs Rabbits Rats Mice (2 animals) (4 animals) (10 animals) (10,6 animals) 100 mg/m3 Eyes No irritation No irritation No irritation No irritation Nasal effects No effects No effects No effects No effects Hair coat Yellow staining. Progressive yellow brown staining Yellow brown staining No staining effects Staining of the appendages and None None None scrotum; ulceration of the skin in the scrotal region. Body weight No change No change No change No change Organ weight No change No change No change Higher liver to body weight ratio than controls Liver enzyme Marked elevation of serum alanine No change No change No change changes aminotransferase and alkaline phosphatase activities Histopathology Hepatocellular degeneration, No treatment related change No treatment related change No treatment related change changes necrosis and inflammation Deaths None None None None Dogs Rabbits Rats Mice (2 animals) (4 animals) (10 animals) (10,6 animals) Table 5 cont… 800 mg/m3 Eye changes Excessive lacrimation due to local Conjunctival redness during the No irritation No changes irritant effect. exposure period. Nasal effects None None Reddish nasal discharge on the None last three exposure days Hair coat Yellow brown staining of the hair A more intense yellow brown staining of Yellow brown staining of the hair No effects coat of the appendages and the hair coat, partial alopecia on the coat scrotum external portion of the ears Skin Ulceration of the skin in the scrotal No effect No effect No effect region Body weight No change No change No change No change
Table 5: Results of repeated inhalation study with potassium amyl xanthate in laboratory animals28 Dogs (2 animals) Rabbits (4 animals) Rats (10 animals) Mice (10,6 animals) 100 mg/m3 Eyes No irritation No irritation No irritation No irritation Nasal effects No effects No effects No effects No effects Hair coat Yellow staining. Progressive yellow brown staining Yellow brown staining No staining effects Staining of the appendages and scrotum; ulceration of the skin in the scrotal region. None None None Body weight No change No change No change No change Organ weight No change No change No change Higher liver to body weight ratio than controls Liver enzyme changes Marked elevation of serum alanine aminotransferase and alkaline phosphatase activities No change No change No change Histopathology changes Hepatocellular degeneration, necrosis and inflammation No treatment related change No treatment related change No treatment related change Deaths None None None None Table 5 cont… Dogs (2 animals) Rabbits (4 animals) Rats (10 animals) Mice (10,6 animals) 800 mg/m3 Eye changes Excessive lacrimation due to local irritant effect. Conjunctival redness during the exposure period. No irritation No changes Nasal effects None None Reddish nasal discharge on the last three exposure days None Hair coat Yellow brown staining of the hair coat of the appendages and scrotum A more intense yellow brown staining of the hair coat, partial alopecia on the external portion of the ears Yellow brown staining of the hair coat No effects Skin Ulceration of the skin in the scrotal region No effect No effect No effect Body weight No change No change No change No change
PEC5-sodium-ethyl-xanthate.docx