Continued Protein product c- one symbol cellular localization biochemical properties c-onc lacking a corresponding v-onc N-ras as and K-ras L-myc as c-myc N-myc as c -myc met cytoplasm tyrosine-specific PK or hepatocyte GF hst ? FGF-related protein ret ? ? mas plasma membrane angiotensin receptor (lacking PK activity) B-Iym ? ? Ick plasma membrane tyrosine-specific PK bcl plasma membrane tyrosine-specific PK G-protein ii trc cytoplasm •I pim-1 serine/threonine PK int-1 secreted glycoprotein int-2 ? FGF-related protein int-1 and int-2 represent the integration locus for mouse mammary tumour virus [253, 1050]. No oncogenic potential has yet been demonstrated for the activated form of these genes per se. The genes bcr and bcl are the breakpoint regions of chromosomes in cells of some leukemias, and lack any oncogenic potential in transfection assay [1050]. A hypothetical oncogene mapping in the bcl locus is pradI [876]. Some authors include one of the homeobox genes, /fox-2.4, as well as the gene coding for interleukin 3 (a multipotential colony stimulating factor), in the oncogene group [141]. Coexpression of Hox- 2.4 (which apparently blocks myeloid differentiation) and IL-3 (which provides the necessary autocrine growth stimulus for myeloid cells) generates murine myeloid leukemias [523, 795]. The rat insulinoma gene (rig) was found to code for a highly conserved nucleoprotein in various tumours, but the possible designation of the as an oncogene was not discussed [951].
Continued c- one Protein product symbol cellular localization biochemical properties c-onc lacking a corresponding v-onc N-ras as and K-ras L-myc as c-myc N-myc as c -myc met cytoplasm tyrosine-specific PK or hepatocyte GF hst ? FGF-related protein ret ? ? mas plasma membrane angiotensin receptor (lacking PK activity) B-Iym ? ? Ick plasma membrane tyrosine-specific PK bcl plasma membrane tyrosine-specific PK G-protein trc cytoplasm ii pim-1 •I serine/threonine PK int-1 secreted glycoprotein int-2 ? FGF-related protein int-1 and int-2 represent the integration locus for mouse mammary tumour virus [253, 1050]. No oncogenic potential has yet been demonstrated for the activated form of these genes per se. The genes bcr and bcl are the breakpoint regions of chromosomes in cells of some leukemias, and lack any oncogenic potential in transfection assay [1050]. A hypothetical oncogene mapping in the bcl locus is pradI [876]. Some authors include one of the homeobox genes, /fox-2.4, as well as the gene coding for interleukin 3 (a multipotential colony stimulating factor), in the oncogene group [141]. Coexpression of Hox- 2.4 (which apparently blocks myeloid differentiation) and IL-3 (which provides the necessary autocrine growth stimulus for myeloid cells) generates murine myeloid leukemias [523, 795]. The rat insulinoma gene (rig) was found to code for a highly conserved nucleoprotein in various tumours, but the possible designation of the as an oncogene was not discussed [951].
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