UK (IHE 8/12) (exclusion criteria included clinical reasons. contraindications to CMR or stress agent) Walcher et al. N=57 patients with suspected SP-CMR + 2 patients were Level IV - - () CAD LGE claustrophobic. Low risk of bias Germany (IHE 8/12) (exclusion criteria included 3 patients refused a second contraindications to CMR, CMR scan. contrast medium or stress agent) Klein et al. () Level IV N=55 patients with suspected SP-CMR + - 1 patient had severe dyspnoea during - CAD LGE adenosine. Germany Low risk of bias (IHE 8/12) (exclusion criteria included contraindications to CMR or stress agent) Ma et al. () Level IV N=50 patients with suspected SP-CMR + - 45 patients experienced mild AEs during - CAD LGE adenosine stress (e.g. breathlessness, China Low risk of bias flushing, headache), but no clinically (IHE 8/12) (exclusion criteria included relevant complications occurred. contraindications to CMR, contrast medium or stress agent) Pereira et al. Level IV N=121 patients with suspected SP-CMR + 4 patients had unknown - 4 patients refused () CAD LGE claustrophobia. catheterisation so Moderate risk of ICA was not Portugal bias (exclusion criteria included performed. (IHE 7.5/12) contraindications to CMR, contrast medium or stress agent) Watkins et al. Level IV N=103 patients with suspected SP-CMR + 3 patients felt - - () angina LGE claustrophobic. Moderate risk of Ireland bias (exclusion criteria included 1 patient suffered anxiety. (IHE 7/12) contraindications to CMR, contrast medium or stress agent) Meyer et al. () Level IV N=60 patients with suspected SP-CMR +LGE - 38 patients had mild side effects such as - occlusive CAD headache, flushing, warmth or mild Germany Moderate risk of
UK (IHE 8/12) (exclusion criteria included contraindications to CMR or stress agent) clinical reasons. Walcher et al. () Germany Level IV Low risk of bias (IHE 8/12) N=57 patients with suspected CAD (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE 2 patients were claustrophobic. 3 patients refused a second CMR scan. - - Klein et al. () Germany Level IV Low risk of bias (IHE 8/12) N=55 patients with suspected CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR + LGE - 1 patient had severe dyspnoea during adenosine. - Ma et al. () China Level IV Low risk of bias (IHE 8/12) N=50 patients with suspected CAD (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE - 45 patients experienced mild AEs during adenosine stress (e.g. breathlessness, flushing, headache), but no clinically relevant complications occurred. - Pereira et al. () Portugal Level IV Moderate risk of bias (IHE 7.5/12) N=121 patients with suspected CAD (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE 4 patients had unknown claustrophobia. - 4 patients refused catheterisation so ICA was not performed. Watkins et al. () Ireland Level IV Moderate risk of bias (IHE 7/12) N=103 patients with suspected angina (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE 3 patients felt claustrophobic. 1 patient suffered anxiety. - - Meyer et al. () Germany Level IV Moderate risk of N=60 patients with suspected occlusive CAD SP-CMR +LGE - 38 patients had mild side effects such as headache, flushing, warmth or mild -
1237-AssessmentReport-Final.docx