Estimating creatinine clearance using Cockcroft-Gault formula This equation is named after the scientists who first published the equation (). It uses serum creatinine in mg/dl, weight in Kilogram and age. The equation is as patients’ follows- CCr= (140 Age) × Mass (in kilograms) × [0.85 if female] / 72 × Serum creatinine – (in mg/dl) If SCr is measured in µmol, then the equation is as follows- CCr= (140 Age) × Mass (in kilograms) × Constant / Serum creatinine (in – µmol/l) Where the constant is 1.23 for men and 1.04 for women This equation overestimates the GFR and secretion of creatinine varies among and within individuals. Therefore, it has been gradually replaced with the Modification of Diet in Renal Disease (MDRD) formula. Estimated GFR (eGFR) using the MDRD formula The MDRD formula () is now used as a marker of kidney function. This equation takes consideration of a serum creatinine, weight, age and ethnicity. However this patient’s formula does not accurately measure the eGFR above 60mL/min/1.73m2 and the simplified four variable version () of the equation sometimes causes misclassification of CKD patients. So, there is much debate about its use and /or replacement (, ). The equation () is as follows- For creatinine in mg/dl: eGFR=186 × Serum creatinine-1.154 × Age-0.203 × [1.212 if Black] × [0.742 if female] For creatinine in µmol/l: eGFR=32788 × serum Creatinine-1.154 ×Age-0.203 × [1.212 if Black] × [0.742 if female] Estimating GFR using CKD-EPI formula The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) was first published in May 2009 (). This was developed to create a formula for better measurement of GFR when the GFR is above 60ml/min, than that of using the MDRD
Estimating creatinine clearance using Cockcroft-Gault formula This equation is named after the scientists who first published the equation (). It uses patients’ serum creatinine in mg/dl, weight in Kilogram and age. The equation is as follows- CCr= (140 – Age) × Mass (in kilograms) × [0.85 if female] / 72 × Serum creatinine (in mg/dl) If SCr is measured in µmol, then the equation is as follows- CCr= (140 – Age) × Mass (in kilograms) × Constant / Serum creatinine (in µmol/l) Where the constant is 1.23 for men and 1.04 for women This equation overestimates the GFR and secretion of creatinine varies among and within individuals. Therefore, it has been gradually replaced with the Modification of Diet in Renal Disease (MDRD) formula. Estimated GFR (eGFR) using the MDRD formula The MDRD formula () is now used as a marker of kidney function. This equation takes consideration of a patient’s serum creatinine, weight, age and ethnicity. However this formula does not accurately measure the eGFR above 60mL/min/1.73m2 and the simplified four variable version () of the equation sometimes causes misclassification of CKD patients. So, there is much debate about its use and /or replacement (, ). The equation () is as follows- For creatinine in mg/dl: eGFR=186 × Serum creatinine-1.154 × Age-0.203 × [1.212 if Black] × [0.742 if female] For creatinine in µmol/l: eGFR=32788 × serum Creatinine-1.154 ×Age-0.203 × [1.212 if Black] × [0.742 if female] Estimating GFR using CKD-EPI formula The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) was first published in May 2009 (). This was developed to create a formula for better measurement of GFR when the GFR is above 60ml/min, than that of using the MDRD
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