Allman et al. () Level III-2 k=24 studies Inclusion criteria: Intervention: USA Quality: 2/11 N=3,088 patients NR Revascularisation Poor quality 35% underwent revascularisation Exclusion criteria: Comparator: SR 65% underwent medical therapy Studies not reporting deaths or where deaths could not be Medical therapy apportioned to patients with versus without viability were Outcomes: excluded. Age mean: 61.4 years (range 55–69) Survival Male: 70.1% (range 38%–91%) Ethnicity: NR Follow-up: mean 24.7 months (range 12–47) Bonow et al. () Level III-1 N=601 patients undergoing assessment for Inclusion criteria: Intervention: myocardial viability USA Quality: 23/26 Patients with angiographic documentation of CAD amenable to CABG + medical therapy 298 patients randomised to medical therapy + surgical revascularisation and with LVD (LVEF <35%) Good quality Comparator: CABG Exclusion criteria: RCT Medical therapy alone 303 randomised to medical therapy alone. Left main coronary artery stenosis of >50%; cardiogenic shock; Outcomes: MI within 3 months; need for aortic valve surgery Mortality rates; hazard ratios Mean age: 60.7 ± 9.4 years Male: 87% Ethnicity: NR Follow-up: median 5.1 years
Allman et al. () USA SR Level III-2 Quality: 2/11 Poor quality k=24 studies N=3,088 patients 35% underwent revascularisation 65% underwent medical therapy Age mean: 61.4 years (range 55–69) Male: 70.1% (range 38%–91%) Ethnicity: NR Follow-up: mean 24.7 months (range 12–47) Inclusion criteria: NR Exclusion criteria: Studies not reporting deaths or where deaths could not be apportioned to patients with versus without viability were excluded. Intervention: Revascularisation Comparator: Medical therapy Outcomes: Survival Bonow et al. () USA RCT Level III-1 Quality: 23/26 Good quality N=601 patients undergoing assessment for myocardial viability 298 patients randomised to medical therapy + CABG 303 randomised to medical therapy alone. Mean age: 60.7 ± 9.4 years Male: 87% Ethnicity: NR Follow-up: median 5.1 years Inclusion criteria: Patients with angiographic documentation of CAD amenable to surgical revascularisation and with LVD (LVEF <35%) Exclusion criteria: Left main coronary artery stenosis of >50%; cardiogenic shock; MI within 3 months; need for aortic valve surgery Intervention: CABG + medical therapy Comparator: Medical therapy alone Outcomes: Mortality rates; hazard ratios
1237-AssessmentReport-Final.docx