CAD = coronary artery disease; DS = diameter stenosis; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; = stress perfusion cardiac magnetic resonance imaging Table 180 Evidence profile for the accuracy of SP-CMR & LGE compared with ICA by coronary artery or segment in patients suspected of having CAD Outcome No. of participants, Risk of bias Inconsistency Indirectness Imprecision Other Effect per 1,000 patients/year QoE No. of studies considerations PTP study PTP Importance Study design 15% prevalence 85% - ICA cut-off 70% DS - - - - - 44% - True N=190 patients 134 392 757 Moderate Not serious Serious Not serious Not serious None positives k=6 studies (124–140) (365–409) (705–791) ⊕⊕⊕⨀ (substantial Cross-sectional heterogeneity; (cohort type accuracy I2 = False study) 16 48 93 negatives (10–26) (31–75) (59–145) True N=241 patients Not serious Serious Not serious Not serious None 705 465 125 Moderate negatives k=6 studies (612–774) (403–510) (108–137) ⊕⊕⊕⨀ (substantial Cross-sectional heterogeneity; (cohort type accuracy I2 = study) False 145 95 25 positives (76–238) (50–157) (13–42) - All studies - - - - - 45% - True N=486 patients Not serious Serious Not serious Not serious None 128 383 722 Moderate positives k=16 studies (123–132) (369–396) (697–748) ⊕⊕⊕⨀ (substantial Cross-sectional heterogeneity; (cohort type accuracy I2 = study) False 22 67 128 negatives (18–27) (54–81) (102–153) True N=604 patients Not serious Not serious Not serious Not serious None 722 468 128 High negatives k=16 studies (689–748) (446–484) (122–132) ⊕⊕⊕⊕ False Cross-sectional positives (cohort type accuracy study) 128 82 22 (102–161) (66–104) (18–28)
CAD = coronary artery disease; DS = diameter stenosis; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; = stress perfusion cardiac magnetic resonance imaging Table 180 Evidence profile for the accuracy of SP-CMR & LGE compared with ICA by coronary artery or segment in patients suspected of having CAD Outcome No. of participants, No. of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations Effect per 1,000 patients/year PTP study PTP 15% prevalence 85% QoE Importance - ICA cut-off 70% DS - - - - - 44% - True positives False negatives N=190 patients k=6 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 134 392 757 (124–140) (365–409) (705–791) 16 48 93 (10–26) (31–75) (59–145) Moderate ⊕⊕⊕⨀ True negatives False positives N=241 patients k=6 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 705 465 125 (612–774) (403–510) (108–137) 145 95 25 (76–238) (50–157) (13–42) Moderate ⊕⊕⊕⨀ - All studies - - - - - 45% - True positives False negatives N=486 patients k=16 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 128 383 722 (123–132) (369–396) (697–748) 22 67 128 (18–27) (54–81) (102–153) Moderate ⊕⊕⊕⨀ True negatives False positives N=604 patients k=16 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Not serious Not serious None 722 468 128 (689–748) (446–484) (122–132) 128 82 22 (102–161) (66–104) (18–28) High ⊕⊕⊕⊕
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