homeless shelters, behavioural treatment programs, dialysis centres) Fan et al. () Prospective N=280/335 included Inclusion: SAT-TB assay NA CIM: time to detection cohort (in-house) and of TB Tuberculosis center for Patients with abnormal chest Mean age: 43 ± 18 years culture (liquid diagnosis and treatment, Level: III-3 radiographic findings compatible with 54 (25%) females medium) Shanghai Pulmonary active TB (TB suspects), > 18 years of Quality: 17.5/26 Hospital, Tongji age, sputum scarce or with negative AFB Some risk of bias University School of microscopy Medicine, Shanghai, Exclusion: China AFB-positive patients and HIV positive Conducted at: patients Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Historical control N=107 (50 in NAAT group and Amplified MTD AFB microscopy Unnecessary TB Guerra et al. () Inclusion: study 57 in non-NAAT group) Direct Test, and culture treatment time School of Medicine, AFB-positive pulmonary TB suspects AFB microscopy Johns Hopkins Level: III-3 Median age NAAT: 46.5 years, undergoing initial diagnostic evaluation Concordance between and culture for University, Baltimore, non-NAAT: 47 years between December 2000 and March MTB results and Quality: 14.5/26 MTB MD, USA 2006 definitive diagnosis, 20 (40%) females in NAAT High risk of bias compared with no MTB Conducted at: group, 11 (19.3%) females in Exclusion: results non-NAAT group Baltimore City Health Anti-TB therapy for > 6 days prior to Department, USA 18 (36%) HIV infected in NAAT sputum collection group (10 unknown), 19 (33.3%) HIV infected in group (10 unknown) Hanrahan et al. () Prospective N=641 (50 NAAT-positive, 591 Inclusion: TB suspects presenting at the Xpert MTB/RIF NA Number of cases cohort study NAAT-negative) clinic, providing consent assay, sputum starting TB treatment University of North AFB FL Carolina Gillings School Level: III-3 Median age: 35 years (IQR Exclusion: Median time to TB microscopy and of Global Public Health, treatment Quality: 16.5/26 Not reported liquid culture for Chapel Hill, North 415 (65%) females Some risk of bias MTB Carolina, USA
homeless shelters, behavioural treatment programs, dialysis centres) Fan et al. () Tuberculosis center for diagnosis and treatment, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Conducted at: Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Prospective cohort Level: III-3 Quality: 17.5/26 Some risk of bias N=280/335 included Mean age: 43 ± 18 years 54 (25%) females Inclusion: Patients with abnormal chest radiographic findings compatible with active TB (TB suspects), > 18 years of age, sputum scarce or with negative AFB microscopy Exclusion: AFB-positive patients and HIV positive patients SAT-TB assay (in-house) and culture (liquid medium) NA CIM: time to detection of TB Guerra et al. () School of Medicine, Johns Hopkins University, Baltimore, MD, USA Conducted at: Baltimore City Health Department, USA Historical control study Level: III-3 Quality: 14.5/26 High risk of bias N=107 (50 in NAAT group and 57 in non-NAAT group) Median age NAAT: 46.5 years, non-NAAT: 47 years 20 (40%) females in NAAT group, 11 (19.3%) females in non-NAAT group 18 (36%) HIV infected in NAAT group (10 unknown), 19 (33.3%) HIV infected in group (10 unknown) Inclusion: AFB-positive pulmonary TB suspects undergoing initial diagnostic evaluation between December 2000 and March 2006 Exclusion: Anti-TB therapy for > 6 days prior to sputum collection Amplified MTD Direct Test, AFB microscopy and culture for MTB AFB microscopy and culture Unnecessary TB treatment time Concordance between MTB results and definitive diagnosis, compared with no MTB results Hanrahan et al. () University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA Prospective cohort study Level: III-3 Quality: 16.5/26 Some risk of bias N=641 (50 NAAT-positive, 591 NAAT-negative) Median age: 35 years (IQR 415 (65%) females Inclusion: TB suspects presenting at the clinic, providing consent Exclusion: Not reported Xpert MTB/RIF assay, sputum AFB FL microscopy and liquid culture for MTB NA Number of cases starting TB treatment Median time to TB treatment
1234_FinalAssessmentReport-accessible.docx