Medical Advisory Stress contrast Echo 48% 10 87% [83, 91] 86% [82, 89] - - - Secretariat () Perfusion analysis 6 88% [84, 90] 65% [59, 70] Moderate Wall motion analysis 6 69% [65, 73] 79% [72, 85] vs ICA ≥50%–70% DS Heijenbrok-Kal et Stress Echo NR 226 79% [78, 81] 87% [86, 89] - - - al. () Exercise Echo 55 83% [80, 85] 84% [80, 88] Poor vs ICA ≥50%–70% DS Geleijnse et al. () Dobutamine Stress Echo - - - in women 41% 14 Poor 72% (weighted mean) 88% (weighted mean) in men 73% 8 77% (weighted mean) 77% (weighted mean) vs ICA ≥50%–70% DS CAD = coronary artery disease; DS = diameter stenosis; Echo = echocardiography; ICA = invasive coronary angiography; NR = not reported; SR = systematic review Table 167 Diagnostic accuracy reported in SRs of Exercise ECG compared with ICA in patients with suspected or known CAD SR Comparison Prevalence Number Sensitivity Specificity Number Sensitivity Specificity of CAD of studies per patient per patient of studies per coronary artery per coronary artery Nielsen et al. () Exercise ECG NR 7 67% [54, 78] 46% [30, 64] - - - Good vs ICA ≥50%–70% DS Dolor et al. () Exercise ECG 41% - - - Good Suspected CAD–women 29 62% [55, 68] 68% [63, 73] Known or suspected 41 61% [54, 67] 65% [58, 72] vs ICA ≥50%–75% DS Kwok et al. () Exercise ECG 38% 19 61% (54, 68) 70% (64, 75) Poor Suspected CAD–women Known or suspected
Medical Advisory Secretariat () Moderate Stress contrast Echo Perfusion analysis Wall motion analysis vs ICA ≥50%–70% DS 48% 10 6 6 87% [83, 91] 88% [84, 90] 69% [65, 73] 86% [82, 89] 65% [59, 70] 79% [72, 85] - - - Heijenbrok-Kal et al. () Poor Stress Echo Exercise Echo vs ICA ≥50%–70% DS NR 226 55 79% [78, 81] 83% [80, 85] 87% [86, 89] 84% [80, 88] - - - Geleijnse et al. () Poor Dobutamine Stress Echo in women in men vs ICA ≥50%–70% DS 41% 73% 14 8 72% (weighted mean) 77% (weighted mean) 88% (weighted mean) 77% (weighted mean) - - - CAD = coronary artery disease; DS = diameter stenosis; Echo = echocardiography; ICA = invasive coronary angiography; NR = not reported; SR = systematic review Table 167 Diagnostic accuracy reported in SRs of Exercise ECG compared with ICA in patients with suspected or known CAD SR Comparison Prevalence of CAD Number of studies Sensitivity per patient Specificity per patient Number of studies Sensitivity per coronary artery Specificity per coronary artery Nielsen et al. () Good Exercise ECG vs ICA ≥50%–70% DS NR 7 67% [54, 78] 46% [30, 64] - - - Dolor et al. () Good Exercise ECG Suspected CAD–women Known or suspected vs ICA ≥50%–75% DS 41% 29 41 62% [55, 68] 61% [54, 67] 68% [63, 73] 65% [58, 72] - - - Kwok et al. () Poor Exercise ECG Suspected CAD–women Known or suspected 38% 19 61% (54, 68) 70% (64, 75)
1237-AssessmentReport-Final.docx