(11).001 1.5 Process Periportal to Zonation of key enzymes (experimental) References Zonation Constant () pericentral ratio in kn=0 no zonation – the model. 0<kn<1 periportal – -1<kn<0 pericentral – Glucose Uptake 1:2.5 Glucokinase (GK) [] (Glucose -> G6P) 1 : 1.5-3.5 Glucose Output 1.9:1 Glucose-6-Phosphatase (G6Pase) [, ] (G6P -> Glucose) 2.3-1.5 : 1 Glycogenesis 3:1 Glycogen Synthase [] 0.5 (G6P-> Glycogen) Periportal no quantitative data found – Glycogenolysis 1:1 Conflicting data in literature perhaps [, ] (no zonation) – dependent on feeding conditions. (Glycogen -> G6P) Glycolysis 1 1:1 6-Phosphofructo-kinaseL (PFKL) []** reported as statistically insignificant (no zonation) difference between sections (Glucose GADP) 1 : 1-1.3** –> Glycolysis 2 1:2.1 Pyruvate KinaseL (PKL) Cited in [] (GADP 1 : 1.66-2.5 [] –> Pyruvate/Lactate)
(11).001 1.5 Process Periportal to pericentral ratio in the model. Zonation of key enzymes (experimental) References Zonation Constant () kn=0 – no zonation 0<kn<1 – periportal -1<kn<0 – pericentral Glucose Uptake (Glucose -> G6P) 1:2.5 Glucokinase (GK) 1 : 1.5-3.5 [] Glucose Output (G6P -> Glucose) 1.9:1 Glucose-6-Phosphatase (G6Pase) 2.3-1.5 : 1 [, ] Glycogenesis (G6P-> Glycogen) 3:1 Glycogen Synthase Periportal – no quantitative data found [] 0.5 Glycogenolysis (Glycogen -> G6P) 1:1 Conflicting data in literature – perhaps dependent on feeding conditions. [, ] (no zonation) Glycolysis 1 (Glucose –> GADP) 1:1 6-Phosphofructo-kinaseL (PFKL) 1 : 1-1.3** []** reported as statistically insignificant difference between sections (no zonation) Glycolysis 2 (GADP –> Pyruvate/Lactate) 1:2.1 Pyruvate KinaseL (PKL) 1 : 1.66-2.5 Cited in [] []
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