risk of bias patients Databases searched: OVID Medline, Medline In-Process and Other Non-Indexed Citations, EMBASE, Cinahl, the Cochrane Library and INAHTA Patients with suspected or known CAD Inclusion criteria: English- or French-language HTAs, English-language SRs, RCTs and Analysis at patient level clinical trials and observational studies with symptomatic adult patients at intermediate PTP of CAD Exclusion criteria: Non-English studies; studies with paediatric patients; patients with low or high PTP of CAD or non-IHD Medical Advisory 36% To compare Echo performed Search period: Stress contrast ICA: DS cut-off Secretariat () (4/11) with microsphere contrast Echo: k=10 at 50% or above 1 January 2004 until 30 June 2009 agents to Echo performed Canada Moderate without contrast and to Databases searched: quality with SPECT a moderate OVID Medline, Medline In-Process and Other Non-Indexed Citations, EMBASE, the risk of bias Cochrane Library and INAHTA Patients with suspected or Inclusion criteria: known CAD HTAs, SRs, RCTs and observational studies with ≥20 adult patients for the Analysis at patient level diagnosis of CAD Exclusion criteria: Non-systematic reviews, case reports and grey literature (e.g. conference abstracts) Medical Advisory 36% What is the diagnostic Search period: Stress SPECT: ICA: DS cut-off Secretariat () (4/11) accuracy of SPECT for the vs ≥50% DS: k=51 at 50% or above Update of SR by Heijenbrok-Kal et al. () diagnosis of CAD compared vs ≥70% DS: k=12 Moderate Canada with the reference standard 1 January 2002 to 30 October 2009 quality with of ICA? a moderate Databases searched:
risk of bias patients Patients with suspected or known CAD Analysis at patient level Databases searched: OVID Medline, Medline In-Process and Other Non-Indexed Citations, EMBASE, Cinahl, the Cochrane Library and INAHTA Inclusion criteria: English- or French-language HTAs, English-language SRs, RCTs and clinical trials and observational studies with symptomatic adult patients at intermediate PTP of CAD Exclusion criteria: Non-English studies; studies with paediatric patients; patients with low or high PTP of CAD or non-IHD Medical Advisory Secretariat () Canada 36% (4/11) Moderate quality with a moderate risk of bias To compare Echo performed with microsphere contrast agents to Echo performed without contrast and to SPECT Patients with suspected or known CAD Analysis at patient level Search period: 1 January 2004 until 30 June 2009 Databases searched: OVID Medline, Medline In-Process and Other Non-Indexed Citations, EMBASE, the Cochrane Library and INAHTA Inclusion criteria: HTAs, SRs, RCTs and observational studies with ≥20 adult patients for the diagnosis of CAD Exclusion criteria: Non-systematic reviews, case reports and grey literature (e.g. conference abstracts) Stress contrast Echo: k=10 ICA: DS cut-off at 50% or above Medical Advisory Secretariat () Canada 36% (4/11) Moderate quality with a moderate What is the diagnostic accuracy of SPECT for the diagnosis of CAD compared with the reference standard of ICA? Search period: Update of SR by Heijenbrok-Kal et al. () 1 January 2002 to 30 October 2009 Databases searched: Stress SPECT: vs ≥50% DS: k=51 vs ≥70% DS: k=12 ICA: DS cut-off at 50% or above
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