a reduction in the metastable zone width and induction time, ultrasound also favours the precipitation of form by improving the surface nucleation. β Ultrasound has previously been used for the crystallization of paracetamol to show the effect of different ultrasound frequencies on the MZW and degradation of paracetamol . Results show that the MZW decreases with ultrasonic frequency and degradation of paracetamol is significantly greater at higher frequencies . Also reported is the melt crystallization of paracetamol using sonication as carrier free approach for enhancing the solubility of poorly soluble drugs. Another very recent report shows that antisolvent sonocrystallization of paracetamol yields monoclinic polymorph (form I) of paracetamol with a smaller crystal size which resulted in a significantly improved compaction behaviour whereas Mori et al. reported the formation of orthorhombic (form II) crystals. However, none of these reports provided systematic investigation on the effect of various sonication experimental parameters such as frequency and power on the crystal size, crystal size distribution and different polymorphs of paracetamol, which will be important for a better understanding of the influence of ultrasound on the crystallization process of paracetamol, and will be the focus of this study. 2. Materials and Methods
a reduction in the metastable zone width and induction time, ultrasound also favours the precipitation of β form by improving the surface nucleation. Ultrasound has previously been used for the crystallization of paracetamol to show the effect of different ultrasound frequencies on the MZW and degradation of paracetamol . Results show that the MZW decreases with ultrasonic frequency and degradation of paracetamol is significantly greater at higher frequencies . Also reported is the melt crystallization of paracetamol using sonication as carrier free approach for enhancing the solubility of poorly soluble drugs. Another very recent report shows that antisolvent sonocrystallization of paracetamol yields monoclinic polymorph (form I) of paracetamol with a smaller crystal size which resulted in a significantly improved compaction behaviour whereas Mori et al. reported the formation of orthorhombic (form II) crystals. However, none of these reports provided systematic investigation on the effect of various sonication experimental parameters such as frequency and power on the crystal size, crystal size distribution and different polymorphs of paracetamol, which will be important for a better understanding of the influence of ultrasound on the crystallization process of paracetamol, and will be the focus of this study. 2. Materials and Methods
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