Germany (IHE 8/12) (exclusion criteria included 105 patients experienced angina pectoris contraindications to CMR) during adenosine stress. No serious adverse side effects of adenosine like anaphylaxis, bronchospasm or serious ventricular arrhythmias occurred during pharmacological stress. Jogiya et al. Level IV N=55 consecutive patients with SP-CMR + 1 patient had 46 patients experienced typical symptoms - () known or suspected CAD. LGE claustrophobia. during adenosine stress. Low risk of bias UK (exclusion criteria included (IHE 9/12) contraindications to CMR or stress agent) Plein et al. () Level IV N= 51 patients with known or SP-CMR +LGE - 40 patients experienced side effects during - suspected CAD the adenosine infusion (e.g. UK and Low risk of bias breathlessness, flushing, headache), but Switzerland (IHE 9/12) (exclusion criteria included no clinically relevant complications contraindications to CMR or stress occurred. agent) Lockie et al. Level IV N=44 patients with known or SP-CMR +LGE 1 patient had 42 patients showed mild symptoms - consistent with adenosine stress but there () suspected CAD. claustrophobia. Low risk of bias were no serious complications. UK (IHE 8/12) (exclusion criteria included contraindications to CMR or contrast agent) Gebker et al. Level IV N=43 consecutive patients with SP-CMR - 1 patient could not complete CMR due to - () known or suspected CAD bronchospasm during adenosine stress. Low risk of bias Germany (IHE 8/12) (exclusion criteria included 31 patients had minimal side effects (e.g. contraindications to CMR or stress flush and dyspnoea). agent) No serious AEs occurred. Pilz et al. () Level IV N=176 consecutive patients SP-CMR + 3 patients had 2 patients had adenosine-induced 171 patients referred with known or suspected LGE claustrophobia bronchospasm. underwent ICA Germany Moderate risk of CAD without major bias complications. (exclusion criteria included
Germany (IHE 8/12) (exclusion criteria included contraindications to CMR) 105 patients experienced angina pectoris during adenosine stress. No serious adverse side effects of adenosine like anaphylaxis, bronchospasm or serious ventricular arrhythmias occurred during pharmacological stress. Jogiya et al. () UK Level IV Low risk of bias (IHE 9/12) N=55 consecutive patients with known or suspected CAD. (exclusion criteria included contraindications to CMR or stress agent) SP-CMR + LGE 1 patient had claustrophobia. 46 patients experienced typical symptoms during adenosine stress. - Plein et al. () UK and Switzerland Level IV Low risk of bias (IHE 9/12) N= 51 patients with known or suspected CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR +LGE - 40 patients experienced side effects during the adenosine infusion (e.g. breathlessness, flushing, headache), but no clinically relevant complications occurred. - Lockie et al. () UK Level IV Low risk of bias (IHE 8/12) N=44 patients with known or suspected CAD. (exclusion criteria included contraindications to CMR or contrast agent) SP-CMR +LGE 1 patient had claustrophobia. 42 patients showed mild symptoms consistent with adenosine stress but there were no serious complications. - Gebker et al. () Germany Level IV Low risk of bias (IHE 8/12) N=43 consecutive patients with known or suspected CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR - 1 patient could not complete CMR due to bronchospasm during adenosine stress. 31 patients had minimal side effects (e.g. flush and dyspnoea). No serious AEs occurred. - Pilz et al. () Germany Level IV Moderate risk of bias N=176 consecutive patients referred with known or suspected CAD (exclusion criteria included SP-CMR + LGE 3 patients had claustrophobia 2 patients had adenosine-induced bronchospasm. 171 patients underwent ICA without major complications.
1237-AssessmentReport-Final.docx