(IHE 6.5/12) obesity and contraindications to undergo CMR. 2 patients had intolerable side-effects, CMR or contrast medium) cause not reported. - - - - - Dipyridamole - Al-Saadi et al. N=40 patients referred for ICA 3 patients had Neither the dipyridamole infusion nor the Level IV SP-CMR - () because of new chest pain or claustrophobia. placement of the central venous catheter Moderate risk of progressive symptoms caused any serious AEs requiring active Germany bias ECG triggering was treatment; however, the usual side effects (exclusion criteria included insufficient because of (IHE 7.5/12) of dipyridamole were observed. contraindications to CMR) frequent premature ventricular complexes in 2 patients, and 1 patient developed atrial fibrillation at the beginning of the CMR scan. Sakuma et al. Level IV N=40 patients with suspected SP-CMR + - No patient experienced life-threatening or - serious adverse reactions during () CAD LGE Moderate risk of pharmacologic stress. Japan bias (IHE 5/12) - - - - - Nitroglycerin - Regenfus et Level IV N=61 patients with clinically SP-CMR None of the patients - - al. () suspected CAD experienced nausea or any Moderate risk of other adverse reaction to Germany bias (exclusion criteria included the contrast agent. (IHE 6/12) contraindications to CMR or stress agent) AE = adverse event; AV block = atrioventricular block; CAD = coronary artery disease; CMR = cardiac magnetic resonance imaging; CTCA = computed tomography coronary angiography; ECG = electrocardiogram; FFR = fractional flow rate; ICA = coronary angiography; IHE = Institute of Health Economics; LBBB = left bundle branch block; LGE = late gadolinium enhancement; PTP = pre-test probability; SP-CMR = stress perfusion CMR
(IHE 6.5/12) obesity and contraindications to CMR or contrast medium) undergo CMR. 2 patients had intolerable side-effects, cause not reported. - - - - - Dipyridamole - Al-Saadi et al. () Germany Level IV Moderate risk of bias (IHE 7.5/12) N=40 patients referred for ICA because of new chest pain or progressive symptoms (exclusion criteria included contraindications to CMR) SP-CMR 3 patients had claustrophobia. ECG triggering was insufficient because of frequent premature ventricular complexes in 2 patients, and 1 patient developed atrial fibrillation at the beginning of the CMR scan. Neither the dipyridamole infusion nor the placement of the central venous catheter caused any serious AEs requiring active treatment; however, the usual side effects of dipyridamole were observed. - Sakuma et al. () Japan Level IV Moderate risk of bias (IHE 5/12) N=40 patients with suspected CAD SP-CMR + LGE - No patient experienced life-threatening or serious adverse reactions during pharmacologic stress. - - - - - - Nitroglycerin - Regenfus et al. () Germany Level IV Moderate risk of bias (IHE 6/12) N=61 patients with clinically suspected CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR None of the patients experienced nausea or any other adverse reaction to the contrast agent. - - AE = adverse event; AV block = atrioventricular block; CAD = coronary artery disease; CMR = cardiac magnetic resonance imaging; CTCA = computed tomography coronary angiography; ECG = electrocardiogram; FFR = fractional flow rate; ICA = coronary angiography; IHE = Institute of Health Economics; LBBB = left bundle branch block; LGE = late gadolinium enhancement; PTP = pre-test probability; SP-CMR = stress perfusion CMR
1237-AssessmentReport-Final.docx