They cause prolonged constriction of smooth muscles. The cause of much antihistamine-resistant asthma in humans. Thromboxanes and Prostaglandins: They are vasoactive causing bronchoconstriction and are chemotactic for neutrophils, eosinophils, basophils, and monocytes. Platelet-Activating Factor "PAF": Activation leads to release of histamine, serotonin, arachidonic acid metabolites. Potent bronchoconstrictor and vasodilator produces shock. Late-Phase Reaction: Occurs within 48h and persists for several days. Clinical consequences of allergic reactions: Allergic rhinitis "hay fever". Food allergics. Atopic dermatitis. Asthma. Clinical Tests: Skin-prick test: Minute amounts of Ag. Wheal and flare response "redness and edema" within 10-15 min. Radioallergosorbent test "FAST": Covalent coupling of allergen to insoluble matrix. Dip into a sample of patients serum, allowed to bind specific Ab for allergen. Wash, radiolabeled Ab specific for IgE is added.
They cause prolonged constriction of smooth muscles. The cause of much antihistamine-resistant asthma in humans. Thromboxanes and Prostaglandins: They are vasoactive causing bronchoconstriction and are chemotactic for neutrophils, eosinophils, basophils, and monocytes. Platelet-Activating Factor "PAF": Activation leads to release of histamine, serotonin, arachidonic acid metabolites. Potent bronchoconstrictor and vasodilator produces shock. Late-Phase Reaction: Occurs within 48h and persists for several days. Clinical consequences of allergic reactions: Allergic rhinitis "hay fever". Food allergics. Atopic dermatitis. Asthma. Clinical Tests: Skin-prick test: Minute amounts of Ag. Wheal and flare response "redness and edema" within 10-15 min. Radioallergosorbent test "FAST": Covalent coupling of allergen to insoluble matrix. Dip into a sample of patients serum, allowed to bind specific Ab for allergen. Wash, radiolabeled Ab specific for IgE is added.
12-hypersensitivity.docx