Tanaka () Level III-2 Risk of bias Patients suspected of Patients with anaemia, renal or Not 6.5% IGT: FPG ROC and having diabetes and hepatic dysfunction excluded. reported 7.8 mmol/L≥ analysis Tokyo, Japan Study of ≥7.0 applicability undergoing OGT 2hPG patients unclear due to testing as part of a <11.1 mmol/L suspected of 2hPG inadequate battery of tests in having diabetes, ≥11.1 description of hospitals in Japan, assessment at population. June 1995 – April two hospitals in Study in 1999. N=866 enrolled, Tokyo. Japan so 66% male, mean age questionable 56 ± 0.4 years, range applicability to 20–82 years. Australian population. Appropriate cut-offs. Risk of bias in N=2,231 patients with Patients had at least one of: Not Not 6.1 mmol/L≥ FPG ROC Tankova () Level III-2 conduct of at least one risk factor relative with diabetes, reported reported FPG ≥7.0 analysis Sofia, Study of study low. for diabetes, referred overweight or central obesity, history <7.0 mmol/L; Bulgaria diabetes Few by doctor or of gestational diabetes, had baby diagnosis in 7.8 mmol/L≥ 2hPG applicability to screening over 4 kg, history of IFG or IGT, people who 2hPG< ≥11.1 program from April hypertension, lipid abnormalities or were doctor- or 11.1 mmol/L 2006 – Oct 2010; atherosclerotic vascular disease. self-referred to population. mean age Exclusions not described. the study 50.3 ± 13.9 years, conducted in a Cut-offs differ 41% male. university from hospital Australian department. guidelines. Table 60: Study profiles of included studies on diagnostic accuracy of HbA1c testing for diagnosing diabetes in older adults Study and Diagnostic level Quality Study population Inclusion/exclusion criteria HbA1c HbA1c Reference Reference Outcomes location of evidence and assessment cut-off— standard standard study design diabetes (FPG cut-off(s): and/or OGT (FPG and/or OGT
Tanaka () Tokyo, Japan Level III-2 Study of patients suspected of having diabetes, assessment at two hospitals in Tokyo. Risk of bias and applicability unclear due to inadequate description of population. Study in Japan so questionable applicability to Australian population. Appropriate cut-offs. Patients suspected of having diabetes and undergoing OGT testing as part of a battery of tests in hospitals in Japan, June 1995 – April 1999. N=866 enrolled, 66% male, mean age 56 ± 0.4 years, range 20–82 years. Patients with anaemia, renal or hepatic dysfunction excluded. Not reported 6.5% IGT: 7.8 mmol/L≥ 2hPG <11.1 mmol/L FPG ≥7.0 2hPG ≥11.1 ROC analysis Tankova () Sofia, Bulgaria Level III-2 Study of diabetes diagnosis in people who were doctor- or self-referred to the study conducted in a university hospital department. Risk of bias in conduct of study low. Few applicability population. Cut-offs differ from Australian guidelines. N=2,231 patients with at least one risk factor for diabetes, referred by doctor or to screening program from April 2006 – Oct 2010; mean age 50.3 ± 13.9 years, 41% male. Patients had at least one of: relative with diabetes, overweight or central obesity, history of gestational diabetes, had baby over 4 kg, history of IFG or IGT, hypertension, lipid abnormalities or atherosclerotic vascular disease. Exclusions not described. Not reported Not reported 6.1 mmol/L≥ FPG <7.0 mmol/L; 7.8 mmol/L≥ 2hPG< 11.1 mmol/L FPG ≥7.0 2hPG ≥11.1 ROC analysis Table 60: Study profiles of included studies on diagnostic accuracy of HbA1c testing for diagnosing diabetes in older adults Study and location Diagnostic level of evidence and study design Quality assessment Study population Inclusion/exclusion criteria HbA1c HbA1c cut-off— diabetes Reference standard (FPG and/or OGT Reference standard cut-off(s): (FPG and/or OGT Outcomes
1267-FinalContractedAssessmentReport-accessible.DOCX