of bias PubMed and the Cochrane Library Stress SPECT: k=103 Pooled meta-analyses of Inclusion criteria: studies included in 11 SRs Meta-analyses on the diagnostic performance of non-invasive imaging tests for the Analysis at patient level diagnosis of CAD with ICA as the reference standard; the absolute numbers of true positives, false negatives, true negatives and false positives of the source studies were available or derivable from the meta-analyses, or from the authors Exclusion criteria: Meta-analyses published before 1990 Iskandar et al. () 64% To perform an SR and Search period: SPECT MPI: ICA: DS cut-off (7/11) bivariate meta-analysis to at 50% USA From inception to January 2012 In women: k=17 compare the diagnostic Good accuracy of SPECT MPI Databases searched: In men: k=13 quality with between men and women low risk of Medline and EMBASE, bibliographies of review articles and relevant chapters of bias central cardiology textbooks Patients with known or Inclusion criteria: suspected CAD English-language literature; prospective studies that provided patient level; Analysis at patient level true and false positives and negatives of at least 20 patients Exclusion criteria: Studies that explicitly stated they were retrospective or reported data of <20 patients of one gender; in case of overlapping publication of study cohorts, only largest study was included Jaarsma et al. () 36% To determine the diagnostic Search period: Stress perfusion: ICA: DS cut-off (4/11) accuracy of the most at 50% or above The Netherlands January 1990 to February 2010 SPECT: k=105 commonly used and UK Moderate invasive myocardial Databases searched: SP-CMR: k=27 quality with perfusion imaging a moderate PubMed modalities, for the diagnosis risk of bias of obstructive CAD Inclusion criteria:
of bias Pooled meta-analyses of studies included in 11 SRs Analysis at patient level PubMed and the Cochrane Library Inclusion criteria: Meta-analyses on the diagnostic performance of non-invasive imaging tests for the diagnosis of CAD with ICA as the reference standard; the absolute numbers of true positives, false negatives, true negatives and false positives of the source studies were available or derivable from the meta-analyses, or from the authors Exclusion criteria: Meta-analyses published before 1990 Stress SPECT: k=103 Iskandar et al. () USA 64% (7/11) Good quality with low risk of bias To perform an SR and bivariate meta-analysis to compare the diagnostic accuracy of SPECT MPI between men and women Patients with known or suspected CAD Analysis at patient level Search period: From inception to January 2012 Databases searched: Medline and EMBASE, bibliographies of review articles and relevant chapters of central cardiology textbooks Inclusion criteria: English-language literature; prospective studies that provided patient level; true and false positives and negatives of at least 20 patients Exclusion criteria: Studies that explicitly stated they were retrospective or reported data of <20 patients of one gender; in case of overlapping publication of study cohorts, only largest study was included SPECT MPI: In women: k=17 In men: k=13 ICA: DS cut-off at 50% Jaarsma et al. () The Netherlands and UK 36% (4/11) Moderate quality with a moderate risk of bias To determine the diagnostic accuracy of the most commonly used myocardial perfusion imaging modalities, for the diagnosis of obstructive CAD Search period: January 1990 to February 2010 Databases searched: PubMed Inclusion criteria: Stress perfusion: SPECT: k=105 SP-CMR: k=27 ICA: DS cut-off at 50% or above invasive
1237-AssessmentReport-Final.docx