CSF cell population CSF identification by antigens immunophenotyping by expressed by the cells, Outcome Exploratory FACS detected by specific antibodies. Quantitative measure of CSF kappa kappa free light chains in Outcome Exploratory CSF. Quantitative measure of CSF myelin basic detectable MBP like Outcome Exploratory protein (MBP) material in CSF. CSF neural cell Measured in ng/mL. adhesion molecule Quantitative measure of Outcome Exploratory (NCAM) soluble NCAM in CSF. CSF neurofilament light Intentionally left blank Outcome Exploratory chains IgG antibodies reacting to aquaporin 4. Biomarker for CSF NMO IgG Outcome Exploratory NMO Devic spectrum disorder. Qualitative detection of two or more IgG Tears OCB Outcome Exploratory electrophoretic bands in tears but not blood. Table for CSF Culture CDE General Comments Purpose Classification Cryptococcus neoformans antigen; Mycobacteria culture. Culture of CSF Diagnosis/ Bacterial, Fungal culture Supplemental to identify presence of a bacterial or Safety fungal pathogen. Gram stain. No identification/growth Diagnosis/ Sterile fluid culture of any microbial pathogen from CSF Supplemental Safety cultures. Table for Blood Tests CDE General Comments Purpose Classification Test for beta subunit of human chorionic gonadotropin; results Pregnancy test, blood reported as positive, Safety Core negative or not done; sensitive to as low as 1mIU/ml serum
CSF immunophenotyping by FACS CSF cell population identification by antigens expressed by the cells, detected by specific antibodies. Outcome Exploratory CSF kappa Quantitative measure of kappa free light chains in CSF. Outcome Exploratory CSF myelin basic protein (MBP) Quantitative measure of detectable MBP like material in CSF. Outcome Exploratory CSF neural cell adhesion molecule (NCAM) Measured in ng/mL. Quantitative measure of soluble NCAM in CSF. Outcome Exploratory CSF neurofilament light chains Intentionally left blank Outcome Exploratory CSF NMO IgG IgG antibodies reacting to aquaporin 4. Biomarker for NMO Devic spectrum disorder. Outcome Exploratory Tears OCB Qualitative detection of two or more IgG electrophoretic bands in tears but not blood. Outcome Exploratory Table for CSF Culture CDE General Comments Purpose Classification Bacterial, Fungal culture Cryptococcus neoformans antigen; Mycobacteria culture. Culture of CSF to identify presence of a bacterial or fungal pathogen. Diagnosis/ Safety Supplemental Sterile fluid culture Gram stain. No identification/growth of any microbial pathogen from CSF cultures. Diagnosis/ Safety Supplemental Table for Blood Tests CDE General Comments Purpose Classification Pregnancy test, blood Test for beta subunit of human chorionic gonadotropin; results reported as positive, negative or not done; sensitive to as low as 1mIU/ml serum Safety Core
F1287_Laboratory_Test_Recommendations.docx