Prothrombin 20210 genetic point mutation Prothrombin gene predisposes to clotting Diagnosis Supplemental mutation negative, heterozygous, homozygous Ratio of PT tested to PT of Prothrombin time/ normal controls, used to international standardize PT sample Safety Supplemental normalized ratio normal range is 0.8-1.2; (PT/INR) measured as a ratio Autoantibodies to cytoplasmic antigens in Protoplasmic-staining neutrophils; positive in AntiNeutrophil several types of Diagnosis Supplemental Cytoplasmic Antibodies vasculidites, e.g. (ANCA) Wegner's, Churg-Strauss; usually given as titers Screening test for antibodies to syphilis in blood; most sensitive in Rapid plasma reagin Secondary Syphilis, less Diagnosis Supplemental (RPR/VDRL) sensitive in primary and tertiary syphilis; should be confirmed with the more specific FTA-ABS test IgM autoantibody against Fc portion of self IgG; can bind to IG to form immune complexes; positive in Rheumatoid factor 80% of patients with Diagnosis Supplemental Rheumatoid Arthritis, 70% of patients with Sjogren's Syndrome, in 5-10% healthy controls Isotype of Ig; sample serum IgA normal range is 70-370 Other Supplemental measured in mg/dL Isotype of Ig; upper limit of serum IgE normal not well defined; Other Supplemental measured in mg/dL Isotype of Ig; sample serum IgG normal range is 700-1450; Other Supplemental measured in mg/dL Isotype of Ig; sample serum IgM normal range is 30-210; Other Supplemental measured in mg/dL
Prothrombin gene mutation Prothrombin 20210 genetic point mutation predisposes to clotting negative, heterozygous, homozygous Diagnosis Supplemental Prothrombin time/ international normalized ratio (PT/INR) Ratio of PT tested to PT of normal controls, used to standardize PT sample normal range is 0.8-1.2; measured as a ratio Safety Supplemental Protoplasmic-staining AntiNeutrophil Cytoplasmic Antibodies (ANCA) Autoantibodies to cytoplasmic antigens in neutrophils; positive in several types of vasculidites, e.g. Wegner's, Churg-Strauss; usually given as titers Diagnosis Supplemental Rapid plasma reagin (RPR/VDRL) Screening test for antibodies to syphilis in blood; most sensitive in Secondary Syphilis, less sensitive in primary and tertiary syphilis; should be confirmed with the more specific FTA-ABS test Diagnosis Supplemental Rheumatoid factor IgM autoantibody against Fc portion of self IgG; can bind to IG to form immune complexes; positive in 80% of patients with Rheumatoid Arthritis, 70% of patients with Sjogren's Syndrome, in 5-10% healthy controls Diagnosis Supplemental serum IgA Isotype of Ig; sample normal range is 70-370 measured in mg/dL Other Supplemental serum IgE Isotype of Ig; upper limit of normal not well defined; measured in mg/dL Other Supplemental serum IgG Isotype of Ig; sample normal range is 700-1450; measured in mg/dL Other Supplemental serum IgM Isotype of Ig; sample normal range is 30-210; measured in mg/dL Other Supplemental
F1287_Laboratory_Test_Recommendations.docx