patients n=33/60 women (55%) older than 30 years or a woman Stress agent: Adenosine events during follow-up. older than 40 years. Quality: high risk of bias CAD risk factors: Contrast agent: Gadolinium hypertension 60% Risk factors included Patient selection LGE: Yes (5-minute delay) hypercholesterolaemia 37% hypertension, hyperlipidaemia, smoker 17% diabetes mellitus, current smoker, Index test Sequence: Stress/rest/LGE diabetes 13% and a family history of MI before Reference standard Image analysis: Perfusion + LGE family history 35% age 55 years. algorithm to detect ischaemia Flow and timing Exclusion criteria: Atypical chest pain; those with a very low or high PTP of having CAD; aortic stenosis with a mean gradient of 40 mm Hg of more; 2nd-degree or higher AV block; pregnancy; haemodynamic or clinical instability; non-cardiac medical problems that could lead to hospital admission; and standard contraindications to CMR imaging. Husser et al. () Level III-1: N=166 patients with chest pain of Inclusion criteria: Scanner: 1.5-T scanner with a Angiographic data was possible coronary origin who Retrospective selection of women array body surface coil evaluated by an Spain A comparison against underwent dipyridamole stress CMR who underwent both CMR and experienced cardiologist independent, blinded Perfusion sequence: First-pass with a and ICA within 3 months ICA within 3 months on a standard digital reference standard notched saturation pulse imaging system among non-consecutive Mean age 65 ± 11 years Exclusion criteria: Image acquisition: During breath-holds patients n=51 women (31%) Patients who had undergone a Mean LVEF: 60 ± 13% Stress agent: Dipyridamole Quality: low risk of bias coronary revascularisation; had Previous MI: 27% had an MI within 3 months before Contrast agent: Gadopentetate Previous PCI: 16% Patient selection the CMR study; or any dimeglumine CAD risk factors: contraindication for dipyridamole Index test LGE: Yes (10-minute delay) hypertension 66% Reference standard hypercholesterolaemia 54% Sequence: Rest/stress/LGE smoker 21% Flow and timing Image analysis: Perfusion and LGE
patients Quality: high risk of bias Patient selection Index test Reference standard Flow and timing n=33/60 women (55%) CAD risk factors: hypertension 60% hypercholesterolaemia 37% smoker 17% diabetes 13% family history 35% older than 30 years or a woman older than 40 years. Risk factors included hypertension, hyperlipidaemia, diabetes mellitus, current smoker, and a family history of MI before age 55 years. Exclusion criteria: Atypical chest pain; those with a very low or high PTP of having CAD; aortic stenosis with a mean gradient of 40 mm Hg of more; 2nd-degree or higher AV block; pregnancy; haemodynamic or clinical instability; non-cardiac medical problems that could lead to hospital admission; and standard contraindications to CMR imaging. Stress agent: Adenosine Contrast agent: Gadolinium LGE: Yes (5-minute delay) Sequence: Stress/rest/LGE Image analysis: Perfusion + LGE algorithm to detect ischaemia events during follow-up. Husser et al. () Spain Level III-1: A comparison against independent, blinded reference standard among non-consecutive patients Quality: low risk of bias Patient selection Index test Reference standard Flow and timing N=166 patients with chest pain of possible coronary origin who underwent dipyridamole stress CMR and ICA within 3 months Mean age 65 ± 11 years n=51 women (31%) Mean LVEF: 60 ± 13% Previous MI: 27% Previous PCI: 16% CAD risk factors: hypertension 66% hypercholesterolaemia 54% smoker 21% Inclusion criteria: Retrospective selection of women who underwent both CMR and ICA within 3 months Exclusion criteria: Patients who had undergone a coronary revascularisation; had had an MI within 3 months before the CMR study; or any contraindication for dipyridamole Scanner: 1.5-T scanner with a body surface coil Perfusion sequence: First-pass with a notched saturation pulse Image acquisition: During breath-holds Stress agent: Dipyridamole Contrast agent: Gadopentetate dimeglumine LGE: Yes (10-minute delay) Sequence: Rest/stress/LGE Image analysis: Perfusion and LGE Angiographic data was evaluated by an experienced cardiologist on a standard digital imaging system array
1237-AssessmentReport-Final.docx