Conducted at: 443 (69%) HIV infected Primary care clinic in 36 (6%) unknown Johannesburg, South Africa Retrospective N=681 patients requested for Xpert MTB/RIF Time to report of results Kwak et al. () Inclusion: NA cohort NAAT assay, from laboratory Division of Pulmonary Patients in whom NAAT was requested mycobacterial and Critical Care Level: III-3 Median age: 61 years (IQR due to suspicion of pulmonary TB Time to confirmation of culture (liquid Medicine, Department of 47.5–73.0) between 1 January 2011 and 31 May results by physician Quality: 16.5/26 and/or solid) Internal Medicine, Seoul 2013 255 (37.4%) females Time to treatment Some risk of bias and AFB National University Exclusion: 5 (0.7%) HIV infected microscopy College of Medicine, Not reported Seoul, Republic of Korea Conducted at: Seoul National University Hospital Retrospective N=115/134 included (77 NAAT, PCR (in-house, No PCR Average delay in Lacroix et al. () Inclusion: cohort 38 no NAAT) not specified) (culture, AFB diagnosis University of Contagious (pulmonary, laryngeal, microscopy, Sherbrooke, Level: III-3 43 (37.4%) females miliary) active TB cases declared to the chest X-ray) Sherbrooke, Quebec, Public Health Department between 1 Quality: 12/26 7 (9.9%) HIV infected Canada January 1998 and 30 June 2007 High risk of bias Conducted at: Exclusion: Public Health Non-respiratory TB, clinical case not Department in confirmed by culture or PCR, incomplete Montegrie (Quebec) file, previous episode of TB, incidentally found cases
Conducted at: Primary care clinic in Johannesburg, South Africa 443 (69%) HIV infected 36 (6%) unknown Kwak et al. () Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Conducted at: Seoul National University Hospital Retrospective cohort Level: III-3 Quality: 16.5/26 Some risk of bias N=681 patients requested for NAAT Median age: 61 years (IQR 47.5–73.0) 255 (37.4%) females 5 (0.7%) HIV infected Inclusion: Patients in whom NAAT was requested due to suspicion of pulmonary TB between 1 January 2011 and 31 May 2013 Exclusion: Not reported Xpert MTB/RIF assay, mycobacterial culture (liquid and/or solid) and AFB microscopy NA Time to report of results from laboratory Time to confirmation of results by physician Time to treatment Lacroix et al. () University of Sherbrooke, Sherbrooke, Quebec, Canada Conducted at: Public Health Department in Montegrie (Quebec) Retrospective cohort Level: III-3 Quality: 12/26 High risk of bias N=115/134 included (77 NAAT, 38 no NAAT) 43 (37.4%) females 7 (9.9%) HIV infected Inclusion: Contagious (pulmonary, laryngeal, miliary) active TB cases declared to the Public Health Department between 1 January 1998 and 30 June 2007 Exclusion: Non-respiratory TB, clinical case not confirmed by culture or PCR, incomplete file, previous episode of TB, incidentally found cases PCR (in-house, not specified) No PCR (culture, AFB microscopy, chest X-ray) Average delay in diagnosis
1234_FinalAssessmentReport-accessible.docx