- SP-CMR + LGE – all - - - - - 42% - True N=261 patients Not serious Serious Not serious Not serious None 128 357 722 Moderate positives k=12 studies (122–132) (340–370) (689–748) ⊕⊕⊕⨀ (substantial Cross-sectional heterogeneity; (cohort type accuracy I2 = False study) 22 63 128 negatives (18–28) (50–80) (102–161) True N=469 patients Not serious Not serious Not serious Not serious None 731 499 129 High negatives k=12 studies (680–765) (464–522) (120–135) ⊕⊕⊕⊕ False Cross-sectional positives (cohort type accuracy study) 119 81 21 (85–170) (58–116) (15–30) SP-CMR & LGE versus: ICA cut-off 70% DS pooled sensitivity = 89% (95%CI 83, 93) and pooled specificity = 83% (95%CI 72, 91); ICA (all studies) pooled sensitivity = 85% (95%CI 82, 88) and pooled specificity = 85% (95%CI 81, 88); SP-CMR + LGE versus ICA (all studies) pooled sensitivity = 85% (95%CI 81, 88) and pooled specificity = 86% (95%CI 80, 90) CAD = coronary artery disease; DS = diameter stenosis; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; = stress perfusion cardiac magnetic resonance imaging
- SP-CMR + LGE – all - - - - - 42% - True positives False negatives N=261 patients k=12 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 128 357 722 (122–132) (340–370) (689–748) 22 63 128 (18–28) (50–80) (102–161) Moderate ⊕⊕⊕⨀ True negatives False positives N=469 patients k=12 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Not serious Not serious None 731 499 129 (680–765) (464–522) (120–135) 119 81 21 (85–170) (58–116) (15–30) High ⊕⊕⊕⊕ SP-CMR & LGE versus: ICA cut-off 70% DS pooled sensitivity = 89% (95%CI 83, 93) and pooled specificity = 83% (95%CI 72, 91); ICA (all studies) pooled sensitivity = 85% (95%CI 82, 88) and pooled specificity = 85% (95%CI 81, 88); SP-CMR + LGE versus ICA (all studies) pooled sensitivity = 85% (95%CI 81, 88) and pooled specificity = 86% (95%CI 80, 90) CAD = coronary artery disease; DS = diameter stenosis; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; = stress perfusion cardiac magnetic resonance imaging
1237-AssessmentReport-Final.docx