Adrenal insufficiency is Baseline and post Short Synacthen Investigation; excluded by a Synacthen cortisol investigation of suspected rise in cortisol values do not apply adrenal insufficiency >200nmol/L and to women on oral a 30 min contraceptives >600nmol/L. Low dose overnight A normal response is suppression of dexamethasone suppression cortisol at 0900hrs to <50nmol/L. test; Investigation of suspected Failure to suppress is indicative of Cushing Syndrome: Cushing’s syndrome. Serum (Red top C-Reactive Protein < 5 mg/L Daily tube) Serum (Red top <190 IU/L (m) See report for Daily or STAT Creatine Kinase Blood tube) <167 IU/L (f) paediatric ranges samples <1hr Serum (Red top 62-106 umol/L tube) or See report for or STAT Creatinine (M) 44-80 Plasma (Green paediatric ranges samples <1hr umol/L (F) top tube) Blood & 24 hr Serum (Red top collection of urine. Blood and tube) and Blood sample Creatinine Clearance 80 - 100 mls/min Urine Universal or 24H should be taken container during the urine collection period. CSF Protein CSF Universal 0.2 - 0.4 g/L STAT sample Contact Laboratory <1hr CSF Glucose CSF Universal 2.5 - 4.7 mmol/L Unique specimens Universal and for Biochemistry. Oligoclonal banding CSF and Blood Serum (Red top Send Blood sample tube) tube with CSF. Specimen should Serum (Red top be taken at least 6 Digoxin Blood 1.2 - 2.6 nmol/L Weekly tube) hours after lasr oral dose. Serum (Red top Blood tube) Electrophoresis See report form Fortnightly EMU- full morning EMU or 24H 24Hr container void or complete 24h colledtion Serum (Red top 6m 15yr 7-140 – Ferritin Blood Daily tube) ug/L
Short Synacthen Investigation; investigation of suspected adrenal insufficiency Adrenal insufficiency is excluded by a rise in cortisol >200nmol/L and a 30 min >600nmol/L. Baseline and post Synacthen cortisol values do not apply to women on oral contraceptives Low dose overnight dexamethasone suppression test; Investigation of suspected Cushing Syndrome: A normal response is suppression of cortisol at 0900hrs to <50nmol/L. Failure to suppress is indicative of Cushing’s syndrome. C-Reactive Protein Serum (Red top tube) < 5 mg/L Daily Creatine Kinase Blood Serum (Red top tube) <190 IU/L (m) <167 IU/L (f) See report for paediatric ranges Daily or STAT samples <1hr Creatinine Serum (Red top tube) or Plasma (Green top tube) 62-106 umol/L (M) 44-80 umol/L (F) See report for paediatric ranges or STAT samples <1hr Creatinine Clearance Blood and Urine Serum (Red top tube) and Universal or 24H container 80 - 100 mls/min Blood & 24 hr collection of urine. Blood sample should be taken during the urine collection period. CSF Protein CSF Universal 0.2 - 0.4 g/L Contact Laboratory STAT sample <1hr CSF Glucose CSF Universal 2.5 - 4.7 mmol/L Oligoclonal banding CSF and Blood Universal and Serum (Red top tube) tube Unique specimens for Biochemistry. Send Blood sample with CSF. Digoxin Blood Serum (Red top tube) 1.2 - 2.6 nmol/L Specimen should be taken at least 6 hours after lasr oral dose. Weekly Electrophoresis Blood Serum (Red top tube) See report form Fortnightly EMU or 24H 24Hr container EMU- full morning void or complete 24h colledtion Ferritin Blood Serum (Red top tube) 6m – 15yr 7-140 ug/L Daily
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