weight No change No change Higher liver to body weight ratio Higher liver to body weight ratio than controls than controls Males had high absolute kidney Higher absolute weight weight and kidney/body weight ratios Marked elevations of alanine No changes High serum alanine No changes Liver enzyme changes aminotransferase and alkaline aminotransferase activity phosphatase activities. Slight elevation of activity Histopathology Hepatocellular degeneration, No changes Microscopically visible granular No changes changes necrosis and inflammation degeneration of the renal tubular epithelial cells Deaths None None One, but not related to exposure 10 from the original group and 5/6 replacement animals died. Convulsions, hyperactivity in 5/16 prior to death
weight No change No change Higher liver to body weight ratio than controls Males had high absolute kidney weight and kidney/body weight ratios Higher liver to body weight ratio than controls Higher absolute weight Liver enzyme changes Marked elevations of alanine aminotransferase and alkaline phosphatase activities. Slight elevation of activity No changes High serum alanine aminotransferase activity No changes Histopathology changes Hepatocellular degeneration, necrosis and inflammation No changes Microscopically visible granular degeneration of the renal tubular epithelial cells No changes Deaths None None One, but not related to exposure 10 from the original group and 5/6 replacement animals died. Convulsions, hyperactivity in 5/16 prior to death
PEC5-sodium-ethyl-xanthate.docx