Medical Advisory Stress SPECT 65% 63 87% [85, 89] 70% [66, 75] - - - Secretariat () Pharm stress SPECT 33 86% [82, 89] 76% [70, 82] Moderate Exercise stress SPECT 20 86% [82, 90] 68% [59, 76] vs ICA ≥50%–70% DS Hacioglu et al. () SPECT MPI NR 8 82% (75–94) 67% (36–100) - - - Poor vs ICA ≥50%–75% DS Heijenbrok-Kal et Stress SPECT NR 103 88% [87, 90] 73% [69, 77] - - - al. () Exercise stress SPECT 48 88% [86, 90] 69% [63, 75] Poor vs ICA ≥50%–70% DS CAD = coronary artery disease; DS = diameter stenosis; FFR = fractional flow rate; ICA = invasive coronary angiography; MPI = myocardial perfusion imaging; NR = not reported; SPECT = single-photon emission computed tomography; SR = systematic review Table 166 Diagnostic accuracy reported in SRs of Echo compared with ICA in patients with suspected or known CAD Prevalence Number Sensitivity Specificity Number Sensitivity Specificity SR Comparison of CAD of studies per patient per patient of studies per coronary artery per coronary artery Lapado et al. () Stress Echo NR 15 84% [80, 89] 77% [69, 86] - - - Moderate vs ICA ≥50%–75% DS de Jong et al. () Stress contrast Echo 66% 10 (all) 87% [81, 91] 72% [56, 83] - - - Moderate In suspected CAD 1 88% [60, 97] 89% [58, 98] vs ICA ≥50% DS 7 86% [79, 92] 74% [63, 82] vs ICA ≥70% DS 3 90% [80, 96] 65% [46, 80] Dolor et al. () Stress Echo 43% - - - Good Suspected CAD–women 14 79% [74, 83] 83% [74, 89] Known or suspected 22 78% [73, 83] 86% [79, 91] vs ICA ≥50%–75% DS
Medical Advisory Secretariat () Moderate Stress SPECT Pharm stress SPECT Exercise stress SPECT vs ICA ≥50%–70% DS 65% 63 33 20 87% [85, 89] 86% [82, 89] 86% [82, 90] 70% [66, 75] 76% [70, 82] 68% [59, 76] - - - Hacioglu et al. () Poor SPECT MPI vs ICA ≥50%–75% DS NR 8 82% (75–94) 67% (36–100) - - - Heijenbrok-Kal et al. () Poor Stress SPECT Exercise stress SPECT vs ICA ≥50%–70% DS NR 103 48 88% [87, 90] 88% [86, 90] 73% [69, 77] 69% [63, 75] - - - CAD = coronary artery disease; DS = diameter stenosis; FFR = fractional flow rate; ICA = invasive coronary angiography; MPI = myocardial perfusion imaging; NR = not reported; SPECT = single-photon emission computed tomography; SR = systematic review Table 166 Diagnostic accuracy reported in SRs of Echo compared with ICA in patients with suspected or known CAD SR Comparison Prevalence of CAD Number of studies Sensitivity per patient Specificity per patient Number of studies Sensitivity per coronary artery Specificity per coronary artery Lapado et al. () Moderate Stress Echo vs ICA ≥50%–75% DS NR 15 84% [80, 89] 77% [69, 86] - - - de Jong et al. () Moderate Stress contrast Echo In suspected CAD vs ICA ≥50% DS vs ICA ≥70% DS 66% 10 (all) 1 7 3 87% [81, 91] 88% [60, 97] 86% [79, 92] 90% [80, 96] 72% [56, 83] 89% [58, 98] 74% [63, 82] 65% [46, 80] - - - Dolor et al. () Good Stress Echo Suspected CAD–women Known or suspected vs ICA ≥50%–75% DS 43% 14 22 79% [74, 83] 78% [73, 83] 83% [74, 89] 86% [79, 91] - - -
1237-AssessmentReport-Final.docx