School of Medicine, 4-day data acquisition Comparator: NA Chicago, Illinois, Indications: USA Acid reflux symptoms, chest pain, laryngeal symptoms that were poorly responsive to twice-daily PPI therapy for a minimum of 6 weeks Gillies et al. () Diagnostic yield 95 patients Inclusion: Index test: Accuracy: study Departments of Indication: See indication System: Bravo™ wireless capsule system Diagnostic yield Upper Symptoms suggestive of Exclusion: Insertion: transorally Gastrointestinal Level: IV GORD or documenting No specific exclusion criteria exist Placement: 6 cm proximal to the SCJ Surgery and the outcome of Duration: 48 hours Gastrointestinal laparoscopic anti-reflux Physiology, Royal surgery Berkshire Hospital, Reading, UK Matched-pairs Grigolon et al. () 102 patients Inclusion: Index test: Accuracy: retrospective cohort Department of Catheter group: 51 All consecutive patients who underwent System: Bravo™ wireless capsule system Diagnostic yield study Gastroenterology, patients, 20 males, mean wireless 96-hour pH monitoring Insertion: NA Concordance (acid Universita Degli Level: III-2 age 48 years (range between January and December 2007 exposure time) Placement: 6 cm above the SCJ Studi and off PPI therapy, and patients Quality: 16.5/26 Incremental diagnostic yield Duration: 48–96 hours Fondazione IRCCS undergoing traditional 24-hour pH Bravo group: 51 patients, C1 (of prolonged monitoring) Comparator for concordance: Ca Granada, monitoring in the same period, after 22 males, mean age P2 System: Slimline mod 901P3001, Ospedale Maggiore matching for the most troublesome 48 years (range 23–82) Medtronic, Denmark Policlinico, Milan, symptom potentially related to GORD, Italy sex and age Insertion: transnasally Exclusion: Placement: 6 cm above the point of sudden change in pH from acid to neutral as Not stated detected by means of continuous rapid withdrawal from the stomach, or 5 cm above the upper margin of the LOS Duration: 24 hours Gunnarsdottir, Diagnostic yield 58 children Inclusion: Index test: Accuracy:
School of Medicine, Chicago, Illinois, USA 4-day data acquisition Indications: Acid reflux symptoms, chest pain, laryngeal symptoms that were poorly responsive to twice-daily PPI therapy for a minimum of 6 weeks Comparator: NA Gillies et al. () Departments of Upper Gastrointestinal Surgery and Gastrointestinal Physiology, Royal Berkshire Hospital, Reading, UK Diagnostic yield study Level: IV 95 patients Indication: Symptoms suggestive of GORD or documenting the outcome of laparoscopic anti-reflux surgery Inclusion: See indication Exclusion: No specific exclusion criteria exist Index test: System: Bravo™ wireless capsule system Insertion: transorally Placement: 6 cm proximal to the SCJ Duration: 48 hours Accuracy: Diagnostic yield Grigolon et al. () Department of Gastroenterology, Universita Degli Studi and Fondazione IRCCS Ca Granada, Ospedale Maggiore Policlinico, Milan, Italy Matched-pairs retrospective cohort study Level: III-2 Quality: 16.5/26 C1 P2 102 patients Catheter group: 51 patients, 20 males, mean age 48 years (range Bravo group: 51 patients, 22 males, mean age 48 years (range 23–82) Inclusion: All consecutive patients who underwent wireless 96-hour pH monitoring between January and December 2007 off PPI therapy, and patients undergoing traditional 24-hour pH monitoring in the same period, after matching for the most troublesome symptom potentially related to GORD, sex and age Exclusion: Not stated Index test: System: Bravo™ wireless capsule system Insertion: NA Placement: 6 cm above the SCJ Duration: 48–96 hours Comparator for concordance: System: Slimline mod 901P3001, Medtronic, Denmark Insertion: transnasally Placement: 6 cm above the point of sudden change in pH from acid to neutral as detected by means of continuous rapid withdrawal from the stomach, or 5 cm above the upper margin of the LOS Duration: 24 hours Accuracy: Diagnostic yield Concordance (acid exposure time) Incremental diagnostic yield (of prolonged monitoring) Gunnarsdottir, Diagnostic yield 58 children Inclusion: Index test: Accuracy:
1203-ContractedAssessmentReport-Catheter-free%20ambulatory%20pH%20test%20for%20GORD%20accessible.docx