Table 18 Diagnostic yield (% of subjects) May Takano Domagk Efthymiou Lenz 2010 2011 2011 2012 2013 DBE 52.0% 50.0% 43.1% 53.0% 48.2% SBE 42.0% 61.1% 36.9% 56.6% 61.7% p-value ns 0.53 0.59 0.70 <0.001 In the four randomised controlled studies there was no significant difference in diagnostic yield between DBE and SBE. In the non-randomised study by Lenz et al (2013), a significant difference in diagnostic yield in favour of SBE was found. However in this study DBE was performed over the period 2004 to 2011, whereas SBE was performed from 2008 to 2011. The authors suggest that a change over time in the reasons for referral for enteroscopy may explain the higher yield with SBE. Therapeutic intervention yield This endpoint refers the percentage of patients in whom a therapeutic intervention (e.g. argon plasma coagulation, endoscopic haemostasis, polypectomy, dilatation) can be undertaken during enteroscopy. It was measured in four studies: Table 19 Therapeutic yield using oral approach only or anal approach only Lenz % of 2013 subjects Oral approach Anal approach DBE 11.1% 3.5% SBE 14.4% 10.4% p-value ns <0.001 ns = not significant Table 20 Therapeutic yield using oral AND anal approaches % of May Takano Domagk Efthymiou Lenz subjects 2010 2011 2011 2012 2013 - 15.0% 9.2% 25.7% - DBE SBE - 11.1% 4.6% 30.0% - p-value - ns 0.49 0.592 - Takano 2011 reported results for and “endoscopic haemostasis” “endoscopic polypectomy”. ns = not significant These findings do not suggest that SBE is associated with inferior ability to perform therapeutic interventions compared with DBE. Biopsy yield. One study (Efthymiou et al 2012) reported on the proportion of patients who had targeted biopsies collected during enteroscopy using oral and anal approaches. Table 21 Therapeutic yield of targeted biopsies using oral AND anal approaches % of Efthymiou subjects 2012
Table 18 Diagnostic yield (% of subjects) May 2010 Takano 2011 Domagk 2011 Efthymiou 2012 Lenz 2013 DBE 52.0% 50.0% 43.1% 53.0% 48.2% SBE 42.0% 61.1% 36.9% 56.6% 61.7% p-value ns 0.53 0.59 0.70 <0.001 In the four randomised controlled studies there was no significant difference in diagnostic yield between DBE and SBE. In the non-randomised study by Lenz et al (2013), a significant difference in diagnostic yield in favour of SBE was found. However in this study DBE was performed over the period 2004 to 2011, whereas SBE was performed from 2008 to 2011. The authors suggest that a change over time in the reasons for referral for enteroscopy may explain the higher yield with SBE. Therapeutic intervention yield This endpoint refers the percentage of patients in whom a therapeutic intervention (e.g. argon plasma coagulation, endoscopic haemostasis, polypectomy, dilatation) can be undertaken during enteroscopy. It was measured in four studies: Table 19 Therapeutic yield using oral approach only or anal approach only % of subjects Lenz 2013 Oral approach Anal approach DBE 11.1% 3.5% SBE 14.4% 10.4% p-value ns <0.001 ns = not significant Table 20 Therapeutic yield using oral AND anal approaches % of subjects May 2010 Takano 2011 Domagk 2011 Efthymiou 2012 Lenz 2013 DBE - 15.0% 9.2% 25.7% - SBE - 11.1% 4.6% 30.0% - p-value - ns 0.49 0.592 - Takano 2011 reported results for “endoscopic haemostasis” and “endoscopic polypectomy”. ns = not significant These findings do not suggest that SBE is associated with inferior ability to perform therapeutic interventions compared with DBE. Biopsy yield. One study (Efthymiou et al 2012) reported on the proportion of patients who had targeted biopsies collected during enteroscopy using oral and anal approaches. Table 21 Therapeutic yield of targeted biopsies using oral AND anal approaches % of subjects Efthymiou 2012
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