contraindication to CMR Objective: Continuous NRI To determine whether the addition of regadenoson stress CMR to a clinical risk model can be used for reclassification of cardiovascular risk Bingham & Level IV: CS N=932 patients Inclusion criteria: Setting: Outpatient clinic NA Early referral to Hachamovitch () referred to stress revascularisation Quality: 8.5/12 Referred for stress CMR MRI machine: 1.5-T scanner CMR of whom 908 USA Cardiovascular risk (98%) were Moderate risk of Exclusion criteria: Stress agent: Adenosine reclassification with the included in the final bias addition of LGE and Moderate to severe valvular Protocol for CMR: Adenosine stress analysis stress perfusion models disease perfusion, myocardial delayed Age, median (25th, to model of baseline enhancement, LV volumes and function Objective: 75th percentiles): patient characteristics and aortic blood flow 65 years (55, 74) To assess the incremental Follow-up: Median (25th, 75th prognostic power of myocardial Male: 59% percentiles): 948 days (639, 1,263) viability, vasodilator stress Ethnicity: NR perfusion, and ventricular wall motion and volumes over patient clinical and historical data alone for the prediction of adverse cardiac events
contraindication to CMR Objective: To determine whether the addition of regadenoson stress CMR to a clinical risk model can be used for reclassification of cardiovascular risk Continuous NRI Bingham & Hachamovitch () USA Level IV: CS Quality: 8.5/12 Moderate risk of bias N=932 patients referred to stress CMR of whom 908 (98%) were included in the final analysis Age, median (25th, 75th percentiles): 65 years (55, 74) Male: 59% Ethnicity: NR Inclusion criteria: Referred for stress CMR Exclusion criteria: Moderate to severe valvular disease Objective: To assess the incremental prognostic power of myocardial viability, vasodilator stress perfusion, and ventricular wall motion and volumes over patient clinical and historical data alone for the prediction of adverse cardiac events Setting: Outpatient clinic MRI machine: 1.5-T scanner Stress agent: Adenosine Protocol for CMR: Adenosine stress perfusion, myocardial delayed enhancement, LV volumes and function and aortic blood flow Follow-up: Median (25th, 75th percentiles): 948 days (639, 1,263) NA Early referral to revascularisation Cardiovascular risk reclassification with the addition of LGE and stress perfusion models to model of baseline patient characteristics
1237-AssessmentReport-Final.docx