USA (IHE 8/12) (exclusion criteria included In 1 patient intravenous stopping adenosine. contraindications to CMR or access could not be stress agent) obtained. N=100 women with symptoms SP-CMR + 1 patient had discomfort 1 patient had severe adenosine-induced Klem et al. () Level IV - suggestive of CAD who were not LGE during CMR and dyspnoea, which quickly resolved after USA and Low risk of bias included in the Klem et al. () study discontinued. stopping adenosine. Germany (IHE 9/12) (exclusion criteria included In 2 patients intravenous contraindications to CMR or access could not be stress agent) obtained. Nagel et al. () Level IV N=90 patients with moderate PTP SP-CMR 3 patients had Most patients had minimal side effects - for CAD claustrophobia. (e.g. flush, warmth, headache). Germany Low risk of bias (IHE 8/12) (exclusion criteria included 1 patient was too obese 6 patients had angina (1 with severe contraindications to CMR or (>150 kg) for scan. symptoms). stress agent) 1 patient had breathing difficulties. 1 patient had AV block III that resolved within 30 seconds after stopping the adenosine infusion. Heitner et al. Level IV N=68 patients with acute chest SP-CMR + 1 patient had There were no AEs or complications - () discomfort and an intermediate LGE claustrophobia. associated with adenosine administration. Low risk of bias PTP of CAD USA (IHE 8/12) 2 patients had body (exclusion criteria included circumference too large to contraindications to CMR or fit in CMR scanner. stress agent) Arnold et al. Level IV N=65 patients for investigation of SP-CMR + 2 patients had No significant AEs occurred during the - () exertional chest pain LGE claustrophobia. scan. Low risk of bias UK (IHE 8/12) (exclusion criteria included contraindications to CMR, contrast medium or stress agent) Cheng et al. Level IV N=65 patients with suspected SP-CMR 2 patients had 1 patient had adenosine intolerance. 1 patient had ICA () CAD claustrophobia. cancelled for Low risk of bias
USA (IHE 8/12) (exclusion criteria included contraindications to CMR or stress agent) In 1 patient intravenous access could not be obtained. stopping adenosine. Klem et al. () USA and Germany Level IV Low risk of bias (IHE 9/12) N=100 women with symptoms suggestive of CAD who were not included in the Klem et al. () study (exclusion criteria included contraindications to CMR or stress agent) SP-CMR + LGE 1 patient had discomfort during CMR and discontinued. In 2 patients intravenous access could not be obtained. 1 patient had severe adenosine-induced dyspnoea, which quickly resolved after stopping adenosine. - Nagel et al. () Germany Level IV Low risk of bias (IHE 8/12) N=90 patients with moderate PTP for CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR 3 patients had claustrophobia. 1 patient was too obese (>150 kg) for scan. Most patients had minimal side effects (e.g. flush, warmth, headache). 6 patients had angina (1 with severe symptoms). 1 patient had breathing difficulties. 1 patient had AV block III that resolved within 30 seconds after stopping the adenosine infusion. - Heitner et al. () USA Level IV Low risk of bias (IHE 8/12) N=68 patients with acute chest discomfort and an intermediate PTP of CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR + LGE 1 patient had claustrophobia. 2 patients had body circumference too large to fit in CMR scanner. There were no AEs or complications associated with adenosine administration. - Arnold et al. () UK Level IV Low risk of bias (IHE 8/12) N=65 patients for investigation of exertional chest pain (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE 2 patients had claustrophobia. No significant AEs occurred during the scan. - Cheng et al. () Level IV Low risk of bias N=65 patients with suspected CAD SP-CMR 2 patients had claustrophobia. 1 patient had adenosine intolerance. 1 patient had ICA cancelled for
1237-AssessmentReport-Final.docx