Moderate risk of bias Prior PCI: 21% (IHE 6/12) CAD risk factors: hypertension 39% hypercholesterolaemia 56% smoker 35% diabetes 15% family history 16% Groothuis et Level IV N=198 patients with low or intermediate Inclusion criteria: Adenosine SP-CMR + LGE al. () PTP of having CAD A case series with either Chest pain and low or intermediate PTP of having CAD according to The post-test or 104 patients had no obstructive CAD on the Diamond/Forrester and CASS scales. Netherlands outcomes CTCA or CMR and did not have ICA and Exclusion criteria: FFR Low risk of bias Any prior history of CAD (prior documented myocardial ischaemia, (IHE 8/12) Mean age, 56 ± 10 years MI, PCI or cardiac surgery), significant arrhythmia, pregnancy, renal n=96 women (50%) insufficiency, known allergy to iodinated contrast material, any PTP according to the combined absolute contra-indication for CMR (e.g. cerebral clips), Diamond/Forrester and CASS scale: claustrophobia, and asthma. low PTP 45% intermediate PTP 33% high PTP 22% CAD risk factors: hypertension 38% hyperlipidaemia 20% smoker 27% diabetes 12% family history 41%
Moderate risk of bias (IHE 6/12) Prior PCI: 21% CAD risk factors: hypertension 39% hypercholesterolaemia 56% smoker 35% diabetes 15% family history 16% Groothuis et al. () The Netherlands Level IV A case series with either post-test or outcomes Low risk of bias (IHE 8/12) N=198 patients with low or intermediate PTP of having CAD 104 patients had no obstructive CAD on CTCA or CMR and did not have ICA and FFR Mean age, 56 ± 10 years n=96 women (50%) PTP according to the combined Diamond/Forrester and CASS scale: low PTP 45% intermediate PTP 33% high PTP 22% CAD risk factors: hypertension 38% hyperlipidaemia 20% smoker 27% diabetes 12% family history 41% Inclusion criteria: Chest pain and low or intermediate PTP of having CAD according to the Diamond/Forrester and CASS scales. Exclusion criteria: Any prior history of CAD (prior documented myocardial ischaemia, MI, PCI or cardiac surgery), significant arrhythmia, pregnancy, renal insufficiency, known allergy to iodinated contrast material, any absolute contra-indication for CMR (e.g. cerebral clips), claustrophobia, and asthma. Adenosine SP-CMR + LGE
1237-AssessmentReport-Final.docx