Chile Low risk of and liquid mouthwash specimens Xpert 11 1 1 147 MTB/RIF assays were bias media performed for patients culture who had discordant results MGIT N=153 specimens AFB (FL) 47 11 30 65 9/162 respiratory Teo et al. () Level III-2 and/or L-J Xpert 70 8 7 68 specimens gave invalid Singapore Low risk of culture - AFB + NAAT 70 14 7 62 GeneXpert results bias n=58 AFB +ve: Xpert 47 5 0 6 n=95 AFB –ve: Xpert 23 3 7 62 N= 122 pulmonary : AFB (FL) 43 9 19 51 Xpert 56 5 6 55 - AFB + NAAT 56 11 6 49 n=52 AFB +ve: Xpert 43 3 0 6 n=70 AFB –ve: Xpert 13 2 6 49 N=31 extrapulmonary AFB (FL) 4 2 11 14 Xpert 14 3 1 13 - AFB + NAAT 14 3 1 13 n=6 AFB +ve: Xpert 4 2 0 0 n=25 AFB –ve: Xpert 10 1 1 13 Ioannidis et al. () Level III-2 MGIT N=92 AFB -ve mixed AFB –ve: Xpert 19 5 3 65 12/105 cultures were and/or L-J specimens contaminated Greece Low risk of culture bias 1/105 had invalid Xpert result Deggim et al. () Level III-2 MGIT 960 N=77 mixed specimens AFB (FL) 14 5 4 54 2/79 had invalid Xpert liquid and - Xpert 15 2 3 57 results Switzerland Low risk of Middlebrook AFB + NAAT 15 7 3 52 bias 7H11 n=19 AFB +ve Xpert 14 0 0 5 culture n=58 AFB –ve Xpert 1 2 3 52
Chile Low risk of bias and liquid media culture mouthwash specimens Xpert 11 1 1 147 MTB/RIF assays were performed for patients who had discordant results Teo et al. () Singapore Level III-2 Low risk of bias MGIT and/or L-J culture N=153 specimens - n=58 n=95 N= 122 pulmonary - n=52 n=70 N=31 extrapulmonary - n=6 n=25 AFB (FL) Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert : AFB (FL) Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert AFB (FL) Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert 47 70 70 47 23 43 56 56 43 13 4 14 14 4 10 11 8 14 5 3 9 5 11 3 2 2 3 3 2 1 30 7 7 0 7 19 6 6 0 6 11 1 1 0 1 65 68 62 6 62 51 55 49 6 49 14 13 13 0 13 9/162 respiratory specimens gave invalid GeneXpert results Ioannidis et al. () Greece Level III-2 Low risk of bias MGIT and/or L-J culture N=92 AFB -ve mixed specimens AFB –ve: Xpert 19 5 3 65 12/105 cultures were contaminated 1/105 had invalid Xpert result Deggim et al. () Switzerland Level III-2 Low risk of bias MGIT 960 liquid and Middlebrook 7H11 culture N=77 mixed specimens - n=19 n=58 AFB (FL) Xpert AFB + NAAT AFB +ve Xpert AFB –ve Xpert 14 15 15 14 1 5 2 7 0 2 4 3 3 0 3 54 57 52 5 52 2/79 had invalid Xpert results
1234_FinalAssessmentReport-accessible.docx