negatives 39 (22–56) True N=2,815 segments Not serious Not serious Very serious Not serious None 198 (132–268) Low negatives k=15 studies ⨁⨁⨀⨀ (considerable Cross-sectional heterogeneity; (cohort type accuracy I2 = >95%) study) False 242 (172–308) positives - LGE-CMR (low cut-off) - - - - - - - True N=3,257 segments Not serious Not serious Very serious Not serious None 382 (294–447) Low positives k=10 (considerable ⨁⨁⨀⨀ Cross-sectional heterogeneity; (cohort type accuracy I2 = >95%) study) False 163 (98–251) negatives True N=2,153 segments Not serious Not serious Very serious Not serious None 309 (255–355) Low negatives k=10 (considerable ⨁⨁⨀⨀ Cross-sectional heterogeneity; (cohort type accuracy I2 = >95%) False study) 146 (100–200) positives LGE-CMR (low cut-off) pooled sensitivity = 70% (95%CI 54, 82) and pooled specificity = 68% (95%CI 56, 78); LGE-CMR (high cut-off) pooled sensitivity = 93% (95%CI 90, 96) and pooled specificity = 45% (95%CI 30, 61) CAD = coronary artery disease; LGE-CMR = late gadolinium enhancement cardiac magnetic resonance imaging; LVD = left ventricular dysfunction; PTP = pre-test probability; QoE= quality of evidence
negatives 39 (22–56) True negatives False positives N=2,815 segments k=15 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Very serious (considerable heterogeneity; I2 = >95%) Not serious None 198 (132–268) 242 (172–308) Low ⨁⨁⨀⨀ - LGE-CMR (low cut-off) - - - - - - - True positives False negatives N=3,257 segments k=10 Cross-sectional (cohort type accuracy study) Not serious Not serious Very serious (considerable heterogeneity; I2 = >95%) Not serious None 382 (294–447) 163 (98–251) Low ⨁⨁⨀⨀ True negatives False positives N=2,153 segments k=10 Cross-sectional (cohort type accuracy study) Not serious Not serious Very serious (considerable heterogeneity; I2 = >95%) Not serious None 309 (255–355) 146 (100–200) Low ⨁⨁⨀⨀ LGE-CMR (low cut-off) pooled sensitivity = 70% (95%CI 54, 82) and pooled specificity = 68% (95%CI 56, 78); LGE-CMR (high cut-off) pooled sensitivity = 93% (95%CI 90, 96) and pooled specificity = 45% (95%CI 30, 61) CAD = coronary artery disease; LGE-CMR = late gadolinium enhancement cardiac magnetic resonance imaging; LVD = left ventricular dysfunction; PTP = pre-test probability; QoE= quality of evidence
1237-AssessmentReport-Final.docx