Intubation 7 days Rats 0, 2% NE Oishi & Fertility-related 10/group Male (~2000) Hiraga, 1980 parameters: Wistar 2000: serum and testis Diet testosterone 2 days Rats 0, 2000 NE Jones et al., Fertility-related 12/group Male 1993 parameters: Wistar 2000: ultrastructural Gavage changes in Leydig cells 150 days Rats 0, 10, 25, 50 NE Pereira et al., Fertility-related 6/group Male ppm (0, 2008b ND parameters: Wistar 0.57, 1.43, 0.57: testis weight, Diet 2.85) testicular antioxidant enzymes, serum testosterone and androstenedione 28 days Rats 0, 250 NE Kwack et al., Fertility-related 6/group Male (MEP) 2009 ND parameters: SD 250: sperm counts & Gavage motility Prenatal developmental toxicity studies GD 5, 10, 15 Rats 0, 0.51, 1.01, NE et al., Developmental: 5/group SD 1.69 mL/kg 500: pup weight, 1972 ip (0, 500, skeletal abnormalities 1000, 1500) GD 0-17 Mice 0, 500, 1600, Tanaka et al., Maternal: Maternal: 17-20/group Jcl:ICR 5600 1600 5600: adrenal and 1987* Dermal kidney weights (reviewed by SCCNFP, Developmental: Developmental: 1600 5600: pup weight, 2002; IPCS, skeletal variations 2003) (rudimentary cervical and lumbar ribs) GD 6-13 Mice 0, 4500 NE Hardin et al., Developmental: 50/group CD-1 4500 1987 Gavage GD 6-15 Rats 0, 0.25, 2.5, Field et al., Maternal: Maternal: 27-32/group CD 5% (0, 200, 200 1900: body weight & 1993 Diet 1900, 3200) food consumption Developmental: Developmental: 1900 3200: skeletal variations (rudimentary lumbar ribs) GD 12-19 Rats 0, 500 NE Liu et al., Developmental: 5/group CD 500 2005 Gavage GD 8-18 Rats 0, 100, 300, NE Howdeshell Maternal: SD 600, 900 900 et al., 2008 Gavage ND Developmental: 900
Intubation 7 days 10/group Rats Male Wistar Diet 0, 2% (~2000) NE Fertility-related parameters: 2000: serum and testis testosterone Oishi & Hiraga, 1980 2 days 12/group Rats Male Wistar Gavage 0, 2000 NE Fertility-related parameters: 2000: ultrastructural changes in Leydig cells Jones et al., 1993 150 days 6/group Rats Male Wistar Diet 0, 10, 25, 50 ppm (0, 0.57, 1.43, 2.85) NE Fertility-related parameters: 0.57: testis weight, testicular antioxidant enzymes, serum testosterone and androstenedione Pereira et al., 2008b ND 28 days 6/group Rats Male SD Gavage 0, 250 (MEP) NE Fertility-related parameters: 250: sperm counts & motility Kwack et al., 2009 ND Prenatal developmental toxicity studies GD 5, 10, 15 5/group Rats SD ip 0, 0.51, 1.01, 1.69 mL/kg (0, 500, 1000, 1500) NE Developmental: 500: pup weight, skeletal abnormalities et al., 1972 GD 0-17 17-20/group Mice Jcl:ICR Dermal 0, 500, 1600, 5600 Maternal: 1600 Developmental: 1600 Maternal: 5600: adrenal and kidney weights Developmental: 5600: pup weight, skeletal variations (rudimentary cervical and lumbar ribs) Tanaka et al., 1987* (reviewed by SCCNFP, 2002; IPCS, 2003) GD 6-13 50/group Mice CD-1 Gavage 0, 4500 Developmental: 4500 NE Hardin et al., 1987 GD 6-15 27-32/group Rats CD Diet 0, 0.25, 2.5, 5% (0, 200, 1900, 3200) Maternal: 200 Developmental: 1900 Maternal: 1900: body weight & food consumption Developmental: 3200: skeletal variations (rudimentary lumbar ribs) Field et al., 1993 GD 12-19 5/group Rats CD Gavage 0, 500 Developmental: 500 NE Liu et al., 2005 GD 8-18 Rats SD Gavage 0, 100, 300, 600, 900 Maternal: 900 Developmental: 900 NE Howdeshell et al., 2008 ND
PEC33-DEP.docx