Helb et al. () Level III-2 MGIT N=107 patients AFB 29 0 53 25 None reported and/or L-J Xpert 67 0 15 25 Vietnam Low risk of media - AFB + NAAT 67 0 15 25 bias culture n=29 AFB +ve: Xpert 29 0 0 0 n=78 AFB –ve: Xpert 38 0 15 25 Al-Ateah et al. Level III-2 MGIT N=56 sputum specimens AFB (FL) 31 0 7 18 None reported () and/or L-J Xpert 37 0 1 18 Low risk of culture - AFB + NAAT 37 0 1 18 Kingdom of bias Saudi Arabia n=31 AFB +ve: Xpert 31 0 0 0 n=25 AFB –ve: Xpert 6 0 1 18 Malbruny et al. Level III-2 MGIT and N=18 sputum specimens AFB (FL) 4 0 1 13 None reported () Coletsos Xpert 5 0 0 13 Low risk of slants - AFB + NAAT 5 0 0 13 France bias n=14 AFB –ve: Xpert 1 0 0 13 Hanrahan et al. MGIT media Level III-2 N=2,082 patients AFB 186 10 186 1,472 None reported () culture Some risk of Xpert 299 47 107 1,638 South Africa bias Theron et al. () Level III-2 MGIT N=480 sputum samples AFB (FL) 102 3 47 328 None reported medium Xpert 115 15 34 316 South Africa Some risk of culture - AFB + NAAT 122 17 27 314 bias n=286 HIV –ve: AFB (FL) 65 2 19 200 Xpert 68 10 16 193 - AFB + NAAT 72 10 12 192 HIV +ve: AFB (FL) 26 1 24 79 n=130 Xpert 35 4 15 76 AFB + NAAT 37 5 13 75 Sohn et al. () Level III-2 Liquid N=435 sputum samples AFB (FL) 7 4 17 407 1/436 invalid Xpert culture Xpert 11 1 13 410 result Canada Some risk of - AFB + NAAT 12 5 12 406 bias n=11 AFB +ve: Xpert 6 0 1 4 n=424 AFB –ve: Xpert 5 1 12 405
Helb et al. () Vietnam Level III-2 Low risk of bias MGIT and/or L-J media culture N=107 patients - n=29 n=78 AFB Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert 29 67 67 29 38 0 0 0 0 0 53 15 15 0 15 25 25 25 0 25 None reported Al-Ateah et al. () Kingdom of Saudi Arabia Level III-2 Low risk of bias MGIT and/or L-J culture N=56 sputum specimens - n=31 n=25 AFB (FL) Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert 31 37 37 31 6 0 0 0 0 0 7 1 1 0 1 18 18 18 0 18 None reported Malbruny et al. () France Level III-2 Low risk of bias MGIT and Coletsos slants N=18 sputum specimens - n=14 AFB (FL) Xpert AFB + NAAT AFB –ve: Xpert 4 5 5 1 0 0 0 0 1 0 0 0 13 13 13 13 None reported Hanrahan et al. () South Africa Level III-2 Some risk of bias MGIT media culture N=2,082 patients AFB Xpert 186 299 10 47 186 107 1,472 1,638 None reported Theron et al. () South Africa Level III-2 Some risk of bias MGIT medium culture N=480 sputum samples - n=286 - n=130 AFB (FL) Xpert AFB + NAAT HIV –ve: AFB (FL) Xpert AFB + NAAT HIV +ve: AFB (FL) Xpert AFB + NAAT 102 115 122 65 68 72 26 35 37 3 15 17 2 10 10 1 4 5 47 34 27 19 16 12 24 15 13 328 316 314 200 193 192 79 76 75 None reported Sohn et al. () Canada Level III-2 Some risk of bias Liquid culture N=435 sputum samples - n=11 n=424 AFB (FL) Xpert AFB + NAAT AFB +ve: Xpert AFB –ve: Xpert 7 11 12 6 5 4 1 5 0 1 17 13 12 1 12 407 410 406 4 405 1/436 invalid Xpert result
1234_FinalAssessmentReport-accessible.docx