positives (59–272) (31–141) (10–48) - LGE - - - - - 45% - True N=449 patients Not serious Not serious Not serious Not serious None 61 185 349 High positives k=5 studies (53–69) (158–207) (298–391) ⊕⊕⊕⊕ Cross-sectional (cohort type accuracy study) False 89 265 501 negatives (81–97) (243–292) (459–552) True N=548 patients Not serious Serious Not serious Not serious None 816 528 144 Moderate negatives k=5 studies (774–842) (501–545) (137–149) ⊕⊕⊕⨀ (substantial False Cross-sectional heterogeneity; positives (cohort type accuracy I2 = study) 34 22 6 (8–76) (5–49) (1–13) SP-CMR & LGE pooled sensitivity = 84% (95%CI 78, 89) and pooled specificity = 88% (95%CI 82, 92); SP-CMR pooled sensitivity = 90% (95%CI 77, 96) and pooled specificity = 84% (95%CI 68, 93); LGE pooled sensitivity = 40% (95%CI 34, 47) and pooled specificity = 96% (95%CI 88, 99) CAD = coronary artery disease; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; SP-CMR = stress perfusion cardiac magnetic resonance imaging Table 184 GRADE assessment of body of evidence for diagnostic accuracy of LGE-CMR in patients diagnosed with CAD and LVD to predict segmental recovery Outcome No. of participants, Risk of bias Indirectness Inconsistency Imprecision Other Effect per 1000 QoE No. of studies considerations patients/year Importance Study design PTP: 56% - LGE-CMR (high cut-off) - - - - - 56% - True N=3,438 segments Not serious Not serious Very serious Not serious None 521 (504–538) Low positives k=15 studies ⨁⨁⨀⨀ (considerable Cross-sectional heterogeneity; (cohort type accuracy I2 = >95%) study) False
positives (59–272) (31–141) (10–48) - LGE - - - - - 45% - True positives False negatives N=449 patients k=5 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Not serious Not serious None 61 185 349 (53–69) (158–207) (298–391) 89 265 501 (81–97) (243–292) (459–552) High ⊕⊕⊕⊕ True negatives False positives N=548 patients k=5 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 816 528 144 (774–842) (501–545) (137–149) 34 22 6 (8–76) (5–49) (1–13) Moderate ⊕⊕⊕⨀ SP-CMR & LGE pooled sensitivity = 84% (95%CI 78, 89) and pooled specificity = 88% (95%CI 82, 92); SP-CMR pooled sensitivity = 90% (95%CI 77, 96) and pooled specificity = 84% (95%CI 68, 93); LGE pooled sensitivity = 40% (95%CI 34, 47) and pooled specificity = 96% (95%CI 88, 99) CAD = coronary artery disease; ICA = invasive coronary angiography; LGE = late gadolinium enhancement; PTP = pre-test probability; QoE= quality of evidence; SP-CMR = stress perfusion cardiac magnetic resonance imaging Table 184 GRADE assessment of body of evidence for diagnostic accuracy of LGE-CMR in patients diagnosed with CAD and LVD to predict segmental recovery Outcome No. of participants, No. of studies Study design Risk of bias Indirectness Inconsistency Imprecision Other considerations Effect per 1000 patients/year PTP: 56% QoE Importance - LGE-CMR (high cut-off) - - - - - 56% - True positives False N=3,438 segments k=15 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Very serious (considerable heterogeneity; I2 = >95%) Not serious None 521 (504–538) Low ⨁⨁⨀⨀
1237-AssessmentReport-Final.docx