Kitagawa et Level IV N=50 patients with known or SP-CMR + - No serious AE was reported during - al. () suspected CAD LGE adenosine stress. Moderate risk of bias (exclusion criteria included Japan (IHE 7/12) contraindications to CMR, contrast medium or stress agent) Bernhardt et Level IV N=34 patients with stable angina SP-CMR - CMR was completed without complications ICA was completed al. () and suspected or known CAD in all patients. without Moderate risk of referred for ICA complications in all Germany bias patients. (IHE 6/12) Thiele et al. () Level IV N=32 patients with suspected or SP-CMR All 32 patients tolerated the All 32 patients tolerated adenosine All 32 patients known CAD imaging procedure and administration well. tolerated the Germany Moderate risk of contrast agent well. tetrofosmin for and UK bias (exclusion criteria included SPECT well. (IHE 7/12) contraindications to CMR or stress agent) - - - - - Adenosine or dobutamine - Bruder et al. Level IV N=10,228 patients on the Stress CMR 5% of mild cases were 745 (7.3%) patients had mild - () EuroCMR registry who underwent allergic reactions after complications. Low risk of bias stress CMR testing for suspected injection of contrast (e.g. 15 75% of events (e.g. dyspnoea, chest pain, (IHE 8/12) or known CAD mild urticarial or European extra systoles) occurred during exanthema). countries dobutamine or adenosine infusion. 7 (0.1%) patients had severe complications. 2 had non-sustained VT and 1 had ventricular fibrillation during dobutamine infusion 2 had overt heart failure, 1 had unstable angina and 1 had an anaphylactic shock during adenosine stress. - - - - - Dobutamine -
Kitagawa et al. () Japan Level IV Moderate risk of bias (IHE 7/12) N=50 patients with known or suspected CAD (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE - No serious AE was reported during adenosine stress. - Bernhardt et al. () Germany Level IV Moderate risk of bias (IHE 6/12) N=34 patients with stable angina and suspected or known CAD referred for ICA SP-CMR - CMR was completed without complications in all patients. ICA was completed without complications in all patients. Thiele et al. () Germany and UK Level IV Moderate risk of bias (IHE 7/12) N=32 patients with suspected or known CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR All 32 patients tolerated the imaging procedure and contrast agent well. All 32 patients tolerated adenosine administration well. All 32 patients tolerated the tetrofosmin for SPECT well. - - - - - Adenosine or dobutamine - Bruder et al. () 15 European countries Level IV Low risk of bias (IHE 8/12) N=10,228 patients on the EuroCMR registry who underwent stress CMR testing for suspected or known CAD Stress CMR 5% of mild cases were allergic reactions after injection of contrast (e.g. mild urticarial or exanthema). 745 (7.3%) patients had mild complications. 75% of events (e.g. dyspnoea, chest pain, extra systoles) occurred during dobutamine or adenosine infusion. 7 (0.1%) patients had severe complications. 2 had non-sustained VT and 1 had ventricular fibrillation during dobutamine infusion 2 had overt heart failure, 1 had unstable angina and 1 had an anaphylactic shock during adenosine stress. - - - - - - Dobutamine -
1237-AssessmentReport-Final.docx