from Bristol Myers Squibb and personal fees from Pfizer, outside the submitted work. MC reports grants from Bloodwise during the conduct of the study; personal fees from Ariad/Incyte and Pfizer, personal fees and non-financial support from Novartis Pharma and Bristol-Myers Squibb, outside the submitted work. FP, CP, TC and LF declare no conflict of interests. TABLE and FIGURE LEGENDS Table 1. Patient characteristics at trial entry. IQR = interquartile range. data are BCR-ABL1 the centralised results at trial entry. Table 2. Effect of various parameters on molecular recurrence. Data are frequency (proportion) for categorical variables, and median (IQR) for continuous variables. Statistical tests are Fisher’s exact test for categorical variables and the Mann-Whitney U-test for continuous variables. 3. Serious adverse events during de-escalation. SAE = serious adverse event. Data are the number of SAEs (number of patients). Grading is according to the National Cancer Institute Common Toxicity criteria. * denotes the single fatality.
from Bristol Myers Squibb and personal fees from Pfizer, outside the submitted work. MC reports grants from Bloodwise during the conduct of the study; personal fees from Ariad/Incyte and Pfizer, personal fees and non-financial support from Novartis Pharma and Bristol-Myers Squibb, outside the submitted work. FP, CP, TC and LF declare no conflict of interests. TABLE and FIGURE LEGENDS Table 1. Patient characteristics at trial entry. IQR = interquartile range. BCR-ABL1 data are the centralised results at trial entry. Table 2. Effect of various parameters on molecular recurrence. Data are frequency (proportion) for categorical variables, and median (IQR) for continuous variables. Statistical tests are Fisher’s exact test for categorical variables and the Mann-Whitney U-test for continuous variables. 3. Serious adverse events during de-escalation. SAE = serious adverse event. Data are the number of SAEs (number of patients). Grading is according to the National Cancer Institute Common Toxicity criteria. * denotes the single fatality.
paper174%202nd%20revision%20Lancet%20Haematology%20FINAL%20with%20tracked%20changes.docx