Table 1: NINDS CDE Workgroup Cognitive – Recommended CDE’s Rating Scale Usage Instrument Diagnostic Screening Administration Severityb Instrumenta Longitudinalc Instrumentd Name Time N/A 2 2 2 30 min ADAS COG◊ Cognitive 1.5 2 3 2 15-20 min Addenbrooke’s Examination-III ACE-III 2 2 2 2 25-30 min CAMCOG-R† Clinician Global Impression N/A N/A 1.5 N/A 40 min of Change (CGIC)◊ 1 1 1 1 30-50 min Mattis DRS-2□ 3 2.5 3 10-12 min 2 MMSE□ Montreal Cognitive 2 1.5 1.5 1 10-15 min Assessment (MoCA)▲ N/A 2 2 2.5 8-20 min PANDA† N/A 2 2 2 17-26 min PD-CRS† 2 2 1.25 3 10-15 min SCOPA-COG◊ Short Portable Mental N/A N/A N/A 3 5 min Status Questionnaire▲ aScreening Instrument - For initial identification of possible disorder; b Rating Scale - For measurement of disorder severity c Longitudinal - Sensitivity to change over time d Diagnostic Criteria and Instrument Categorization of patients into those with and without a disorder – Instrument available from author– refer to Instrument Summary for information on availability † Instrument available in public domain refer to Instrument Summary for information on availability – ◊ to investigators– refer to Instrument Summary for information on availability ▲ Free Instrument refer to Instrument Summary for information on availability □ Copyrighted – Please note: Each of the above scales are being given a score of 1, 2, 3 for suitability (1= highest or best, 3= lowest or worst)
Table 1: NINDS CDE Workgroup – Cognitive Recommended CDE’s Instrument Name Rating Scale Usage Screening Instrumenta Severityb Longitudinalc Diagnostic Instrumentd Administration Time ADAS COG◊ 2 2 N/A 2 30 min Addenbrooke’s Cognitive Examination-III ACE-III 1.5 2 3 2 15-20 min CAMCOG-R† 2 2 2 2 25-30 min Clinician Global Impression of Change (CGIC)◊ N/A N/A 1.5 N/A 40 min Mattis DRS-2□ 1 1 1 1 30-50 min MMSE□ 3 2.5 2 3 10-12 min Montreal Cognitive Assessment (MoCA)▲ 1.5 1.5 1 2 10-15 min PANDA† 2 2 N/A 2.5 8-20 min PD-CRS† 2 2 N/A 2 17-26 min SCOPA-COG◊ 2 1.25 2 3 10-15 min Short Portable Mental Status Questionnaire▲ 3 N/A N/A N/A 5 min aScreening Instrument - For initial identification of possible disorder; b Rating Scale - For measurement of disorder severity c Longitudinal - Sensitivity to change over time d Diagnostic Criteria and Instrument – Categorization of patients into those with and without a disorder † Instrument available from author– refer to Instrument Summary for information on availability ◊ Instrument available in public domain – refer to Instrument Summary for information on availability ▲ Free to investigators– refer to Instrument Summary for information on availability □ Copyrighted Instrument – refer to Instrument Summary for information on availability Please note: Each of the above scales are being given a score of 1, 2, 3 for suitability (1= highest or best, 3= lowest or worst)
F0774_Cognitive_Guidelines_for_CDE_Use.docx