COPD chronic obstructive pulmonary disease DPT diffuse pleural thickening EDS energy dispersive spectroscopy EPA Environmental Protection Agency FEV1 forced expiratory volume in one second IARC International Agency for Research on Cancer ICD International Classification of Diseases ILO International Labor Organization IRIS Integrated Risk Information System IUR inhalation unit risk LAA Libby Amphibole asbestos LOAEL Lowest Observed Adverse Effect Level LPT Localized Pleural Thickening MCMC Markov Chain Monte Carlo MOA mode of action NAS National Academy of Sciences NCI National Cancer Institute NIOSH National Institute for Occupational Safety and Health NOAEL No Observed Adverse Effect Level NRC National Research Council NTP National Toxicology Program OR odds ratio ORD Office of Research and Development PCM phase contrast microscopy PCME phase contrast microscopy equivalent POD point of departure RfC reference concentration ROS reactive oxygen species RR relative risk RTW residence time-weighted SAED Selected Area Electron Diffraction SEER Surveillance, Epidemiology, and End Results SEM scanning electron microscopy SMR standardized mortality ratio SIR standardized incidence ratio TEM transmission electron microscopy Th1 T Helper Cell Type 1 Th2 T Helper Cell Type 2 TSFE time since first exposure UCL Upper Confidence Limit UF uncertainty factor UFD Database uncertainty factor UFH Human inter-individual variability uncertainty factor UFL LOAEL-to-NOAEL uncertainty factor UFS subchronic-to-chronic uncertainty factor WDS wavelength dispersive spectroscopy XRD X-ray diffraction
COPD chronic obstructive pulmonary disease DPT diffuse pleural thickening EDS energy dispersive spectroscopy EPA Environmental Protection Agency FEV1 forced expiratory volume in one second IARC International Agency for Research on Cancer ICD International Classification of Diseases ILO International Labor Organization IRIS Integrated Risk Information System IUR inhalation unit risk LAA Libby Amphibole asbestos LOAEL Lowest Observed Adverse Effect Level LPT Localized Pleural Thickening MCMC Markov Chain Monte Carlo MOA mode of action NAS National Academy of Sciences NCI National Cancer Institute NIOSH National Institute for Occupational Safety and Health NOAEL No Observed Adverse Effect Level NRC National Research Council NTP National Toxicology Program OR odds ratio ORD Office of Research and Development PCM phase contrast microscopy PCME phase contrast microscopy equivalent POD point of departure RfC reference concentration ROS reactive oxygen species RR relative risk RTW residence time-weighted SAED Selected Area Electron Diffraction SEER Surveillance, Epidemiology, and End Results SEM scanning electron microscopy SMR standardized mortality ratio SIR standardized incidence ratio TEM transmission electron microscopy Th1 T Helper Cell Type 1 Th2 T Helper Cell Type 2 TSFE time since first exposure UCL Upper Confidence Limit UF uncertainty factor UFD Database uncertainty factor UFH Human inter-individual variability uncertainty factor UFL LOAEL-to-NOAEL uncertainty factor UFS subchronic-to-chronic uncertainty factor WDS wavelength dispersive spectroscopy XRD X-ray diffraction
EPA-SAB-13-001-unsigned.docx