has changed since this study was done. Limited applicability to Australian setting. Englegau () Low risk of N=1,018 people who had a Analysis included subjects with Retinal photo HbA1c FPG and ROC Level III-2 Cairo and bias in random blood glucose all blood glucose and taken and graded continuum 2hPG analysis, High-risk rural conduct of measure of ≥5.6 mmol/L at retinopathy measures; overall by external staff continuum only subgroup of surrounds, study, baseline survey, plus participation rate 50%. using modified sensitivity randomly although likely random sample of those Airlie house and Egypt sampled that quality of below; about 2/3 sample at classification. specificity population tests has high risk or with diabetes. reported invited for changed since Analysis conducted with further testing this study was and without people with including OGT done. diabetes. Description and retinal limited; mean age 45 years, photographs; Limited 41% male. further testing applicability to appears Australia concurrent. given Egyptian setting. Table 58: Study profiles of included studies on diagnostic accuracy of HbA1c testing for diagnosing diabetes: studies included in meta-analysis Study and Diagnostic Quality Study population Inclusion/exclusion criteria HbA1c HbA1c Reference Reference Outcomes location level of assessment cut-off— cut-off— standard standard evidence and diabetes (FPG cut-off(s): and/or OGT (FPG study design and/or OGT
has changed since this study was done. Limited applicability to Australian setting. Englegau () Cairo and rural surrounds, Egypt Level III-2 High-risk subgroup of randomly sampled population invited for further testing including OGT and retinal photographs; further testing appears concurrent. Low risk of bias in conduct of study, although likely that quality of tests has changed since this study was done. Limited applicability to Australia given Egyptian setting. N=1,018 people who had a random blood glucose measure of ≥5.6 mmol/L at baseline survey, plus random sample of those below; about 2/3 sample at high risk or with diabetes. Analysis conducted with and without people with diabetes. Description limited; mean age 45 years, 41% male. Analysis included subjects with all blood glucose and retinopathy measures; overall participation rate 50%. Retinal photo taken and graded by external staff using modified Airlie house classification. HbA1c continuum FPG and 2hPG continuum ROC analysis, only sensitivity and specificity reported Table 58: Study profiles of included studies on diagnostic accuracy of HbA1c testing for diagnosing diabetes: studies included in meta-analysis Study and location Diagnostic level of evidence and study design Quality assessment Study population Inclusion/exclusion criteria HbA1c cut-off— HbA1c cut-off— diabetes Reference standard (FPG and/or OGT Reference standard cut-off(s): (FPG and/or OGT Outcomes
1267-FinalContractedAssessmentReport-accessible.DOCX