Reference standard smoker 43% bismethylamide diabetes 19% Flow and timing LGE: No family history 26% Sequence: Stress n=10 without CAD Mean age, 50 ± 12 years 5/10 women (50%) Mean LVEF: 73 ± 4 CAD risk factors: hypertension 60% hypercholesterolaemia 100% smoker 80% diabetes 0% family history 50% Stolzmann et Level II: N=60 consecutive patients referred to Exclusion criteria: Scanner: 1.5-T scanner with cardiac Angiograms were obtained al. () CA who all had an intermediate risk of Contraindications for adenosine phased-array receiver coils in at least two orthogonal A comparison against having CAD based on the Diamond (e.g. 2nd or 3rd AV block, sick projections according to Switzerland independent, blinded Perfusion sequence: First-pass with a sinus syndrome, symptomatic standard techniques. and criteria reference standard saturation recovery gradient echo pulse bradycardia, severe asthma or Coronary angiograms of among consecutive Mean age, 64 ± 10 years obstructive pulmonary disease) or the target vessels were Image acquisition: During breath-holds patients n=8 women (13%) to CMR (e.g. implanted electronic evaluated by consensus of Stress agent: Adenosine CAD risk factors: devices, metallic foreign bodies in two readers. Quality: low risk of bias the eye, severe claustrophobia, hypertension 77% Contrast agent: Gadobutrolum Patient selection and others according to local hyperlipidaemia 72% LGE: Yes (10-minute delay) regulations and manufacturer’s smoker 33% Index test recommendations) diabetes 15% Sequence: Stress/rest/LGE Reference standard family history 18% Image analysis: Either perfusion or Flow and timing LGE defects scored positive Takase et al. Level III-2 N=57 consecutive patients with Inclusion criteria: Scanner: 1.5-T scanner with a phased ICA was performed using () suspected CAD array cardiac coil the standard Judkins A comparison with Referred to the National Defense technique and the Japan reference standard (not Mean age, 66 ± 10 years Medical College Hospital and who Perfusion sequence: First-pass presence of significant blinded or blinding not n=17 women (17%) agreed to undergo the stenosis (>50%) was Image acquisition: During breath-holds dipyridamole stress perfusion
Reference standard Flow and timing smoker 43% diabetes 19% family history 26% n=10 without CAD Mean age, 50 ± 12 years 5/10 women (50%) Mean LVEF: 73 ± 4 CAD risk factors: hypertension 60% hypercholesterolaemia 100% smoker 80% diabetes 0% family history 50% bismethylamide LGE: No Sequence: Stress Stolzmann et al. () Switzerland Level II: A comparison against independent, blinded reference standard among consecutive patients Quality: low risk of bias Patient selection Index test Reference standard Flow and timing N=60 consecutive patients referred to CA who all had an intermediate risk of having CAD based on the Diamond and criteria Mean age, 64 ± 10 years n=8 women (13%) CAD risk factors: hypertension 77% hyperlipidaemia 72% smoker 33% diabetes 15% family history 18% Exclusion criteria: Contraindications for adenosine (e.g. 2nd or 3rd AV block, sick sinus syndrome, symptomatic bradycardia, severe asthma or obstructive pulmonary disease) or to CMR (e.g. implanted electronic devices, metallic foreign bodies in the eye, severe claustrophobia, and others according to local regulations and manufacturer’s recommendations) Scanner: 1.5-T scanner with cardiac phased-array receiver coils Perfusion sequence: First-pass with a saturation recovery gradient echo pulse Image acquisition: During breath-holds Stress agent: Adenosine Contrast agent: Gadobutrolum LGE: Yes (10-minute delay) Sequence: Stress/rest/LGE Image analysis: Either perfusion or LGE defects scored positive Angiograms were obtained in at least two orthogonal projections according to standard techniques. Coronary angiograms of the target vessels were evaluated by consensus of two readers. Takase et al. () Japan Level III-2 A comparison with reference standard (not blinded or blinding not N=57 consecutive patients with suspected CAD Mean age, 66 ± 10 years n=17 women (17%) Inclusion criteria: Referred to the National Defense Medical College Hospital and who agreed to undergo the dipyridamole stress perfusion Scanner: 1.5-T scanner with a phased array cardiac coil Perfusion sequence: First-pass Image acquisition: During breath-holds ICA was performed using the standard Judkins technique and the presence of significant stenosis (>50%) was
1237-AssessmentReport-Final.docx