by DST Hillemann et al. Level III-2 DST N=29 culture-positive Xpert RIF 0 1 0 28 3/29 culture-positive () non-respiratory specimens by Xpert NAAT Low risk of had an indeterminate RIF specimens Germany bias resistance result Theron et al. () Level III-2 DST with N=27 culture-positive RIF resistance None reported MGIT SIRE BAL samples South Africa Low risk of Xpert RIF 1 3 0 23 bias MDR Xpert RIF 1 3 0 23 BACTEC N=18 culture-positive Deggim et al. () Level III-2 Xpert RIF 0 2 0 16 None reported MGIT 960 mixed specimens Switzerland Low risk of bias Sohn et al. () Level III-2 DST N=501 culture-positive Xpert RIF 1 1 0 499 1/502 specimens had sputum samples contaminated cultures Canada Some risk of 44/502 had invalid Xpert bias results and were repeated Halse et al. () Level III-2 DST N=143 culture-positive rpoB pyrosequencing 2 1 1 139 None reported mixed specimens Some risk of USA bias Marlowe et al. () Level III-2 DST N=130 culture-positive Xpert RIF 0 3 0 127 None reported respiratory specimens USA Some risk of bias Zeka, Tasbakan Level III-2 DST N=89 culture-positive RIF resistance None reported & Cavusoglu () mixed specimens Some risk of Xpert RIF 1 0 0 88 Turkey bias N=58 pulmonary MDR N=31 extrapulmonary Xpert RIF 1 0 4 84
by DST Hillemann et al. () Germany Level III-2 Low risk of bias DST N=29 culture-positive non-respiratory specimens Xpert RIF 0 1 0 28 3/29 culture-positive specimens by Xpert NAAT had an indeterminate RIF resistance result Theron et al. () South Africa Level III-2 Low risk of bias DST with MGIT SIRE N=27 culture-positive BAL samples RIF resistance Xpert RIF MDR Xpert RIF 1 1 3 3 0 0 23 23 None reported Deggim et al. () Switzerland Level III-2 Low risk of bias BACTEC MGIT 960 N=18 culture-positive mixed specimens Xpert RIF 0 2 0 16 None reported Sohn et al. () Canada Level III-2 Some risk of bias DST N=501 culture-positive sputum samples Xpert RIF 1 1 0 499 1/502 specimens had contaminated cultures 44/502 had invalid Xpert results and were repeated Halse et al. () USA Level III-2 Some risk of bias DST N=143 culture-positive mixed specimens rpoB pyrosequencing 2 1 1 139 None reported Marlowe et al. () USA Level III-2 Some risk of bias DST N=130 culture-positive respiratory specimens Xpert RIF 0 3 0 127 None reported Zeka, Tasbakan & Cavusoglu () Turkey Level III-2 Some risk of bias DST N=89 culture-positive mixed specimens N=58 pulmonary N=31 extrapulmonary RIF resistance Xpert RIF MDR Xpert RIF 1 1 0 0 0 4 88 84 None reported
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