the generation of a highly transforming gene. CELLULAR ONCOGENES [108, 253, 372, 1050] Protein product c-onc symbol cellular localization biochemical properties c-onc that are the homologues of viral oncogene src plasma membrane tyrosine-specific PK it fps it fes ti yes ii fgr ii ros ti abl ski nucleus DNA-binding protein it erbA DNA-binding thyreoid- hormone receptor erbB (neu) plasma membrane EGF receptor fms cytoplasm tyrosine-specific PK raf plasma membrane serine/threonine PK ii ii mil myc nucleus DNA-binding protein ii ii myb the jun protein it fos binds it ets DNA-binding protein mos cytoplasm serine/threonine PK H-ras plasma membrane GTP/GDP-binding GTPase ii ii K-ras sis secreted PDGF- B-chain rel cytoplasm ? kit plasma membrane tyrosine-specific PK fos jun nucleus complexes with the protein
the generation of a highly transforming gene. CELLULAR ONCOGENES [108, 253, 372, 1050] c-onc Protein product symbol cellular localization biochemical properties c-onc that are the homologues of viral oncogene src plasma membrane tyrosine-specific PK fps it fes it yes ti fgr ii ros ii abl ti ski nucleus DNA-binding protein erbA it DNA-binding thyreoid- hormone receptor erbB (neu) plasma membrane EGF receptor fms cytoplasm tyrosine-specific PK raf plasma membrane serine/threonine PK mil ii ii myc nucleus DNA-binding protein myb ii ii fos it binds the jun protein ets it DNA-binding protein mos cytoplasm serine/threonine PK H-ras plasma membrane GTP/GDP-binding GTPase K-ras ii ii sis secreted PDGF- B-chain rel cytoplasm ? kit plasma membrane tyrosine-specific PK jun nucleus complexes with the fos protein
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