Table 1 Acute oral toxicity of TGIC LD50 Dose mg/kg Chemical Species mg/kg Pathology Ref TK Rat: < 100 (m) 100- Oedematous and haemorrhagic 2 Tif, RAI 255 (f) 500 lungs; liquid-filled thoracic cavity; f (SPF) (0.5% CMC) spotted, haemorrhagic or involuted thymus; involuted testes; enlarged kidney; dilated stomach; dilated small intestine TK 10622 Rat: 302 (m) 100- No compound-related gross organ 3 Tif, RAI 305 (f) 1000 changes f (SPF) (A.O.) TEPIC Rat: 447 (m) 100- Haemorrhagic lungs; dark or pale 4 Sprague- 948 (f) 1290 liver;intestinal haemorrhage; Dawley (A.O.) pale kidneys; sloughing and CFY haemorrhage of gastric epithelia TK 10622 Hamster 1672 (m/f) 300- No compound-related gross organ 5 (A.O.) 3000 changes TK Rat: 431 (m/f) 100- No compound-related gross organ 6 Tif, RAI (2% CMC) 1290 changes f (SPF) m males f females CMC carboxymethylcellulose, vehicle A.O. arachid oil, vehicle
Table 1 Acute oral toxicity of TGIC Chemical Species LD50 mg/kg Dose mg/kg Pathology Ref TK Rat: < 100 (m) 100- Oedematous and haemorrhagic 2 Tif, RAI f (SPF) 255 (f) (0.5% CMC) 500 lungs; liquid-filled thoracic cavity; spotted, haemorrhagic or involuted thymus; involuted testes; enlarged kidney; dilated stomach; dilated small intestine TK 10622 Rat: 302 (m) 100- No compound-related gross organ 3 Tif, RAI f (SPF) 305 (f) (A.O.) 1000 changes TEPIC Rat: 447 (m) 100- Haemorrhagic lungs; dark or pale 4 Sprague- Dawley CFY 948 (f) (A.O.) 1290 liver;intestinal haemorrhage; pale kidneys; sloughing and haemorrhage of gastric epithelia TK 10622 Hamster 1672 (m/f) 300- No compound-related gross organ 5 (A.O.) 3000 changes TK Rat: 431 (m/f) 100- No compound-related gross organ 6 Tif, RAI f (SPF) (2% CMC) 1290 changes m males f females CMC carboxymethylcellulose, vehicle A.O. arachid oil, vehicle
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