patients. Meyer et al. Level III-2 N=60 patients with SP-CMR or LGE ICA ≥50% DS - () suspected occlusive CAD Low risk of Per patient 60% 32 5 4 19 Germany bias N=180 vessels Per segment 47 16 15 102 and USA Merkle et al. Level III-2 N=59 patients with SP-CMR ICA ≥70% DS 22% 13 9 0 37 An increase in heart rate >10% during adenosine infusion was () suspected CAD Low risk of ICA ≥50% DS 31% 15 7 3 34 achieved in 204/228 (89.5%) Germany bias patients. Transient AV block grade III occurred in 14/228 patients (6.1%) and resulted in trigger dropouts. All patients included in ITT analysis Takase et al. Level III-2 N=57 patients with SP-CMR or LGE ICA ≥50% DS 54% 28 4 3 22 - () suspected CAD Low risk of Japan bias Falcao et al. Level III-2 N=42/57 patients with SP-CMR ICA ≥50% DS 60% 23 3 2 14 10/57 patients did not undergo () suspected CAD CMR Low risk of 2/57 had claustrophobia Brazil bias 2/57 had inadequate CMR images 1/57 patients had PCI. Kirschbaum Level III-2 N=75 vessels from SP-CMR Per artery NR - et al. () patients with stable Unclear risk of MPR <1.8 FFR <0.8 27 14 5 29 angina and suspected The bias CAD with normal LVEF MPR <1.9 31 17 1 26 Netherlands MPR <2.0 31 19 1 24
patients. Meyer et al. () Germany and USA Level III-2 Low risk of bias N=60 patients with suspected occlusive CAD N=180 vessels SP-CMR or LGE ICA ≥50% DS Per patient Per segment 60% 32 47 5 16 4 15 19 102 - Merkle et al. () Germany Level III-2 Low risk of bias N=59 patients with suspected CAD SP-CMR ICA ≥70% DS ICA ≥50% DS 22% 31% 13 15 9 7 0 3 37 34 An increase in heart rate >10% during adenosine infusion was achieved in 204/228 (89.5%) patients. Transient AV block grade III occurred in 14/228 patients (6.1%) and resulted in trigger dropouts. All patients included in ITT analysis Takase et al. () Japan Level III-2 Low risk of bias N=57 patients with suspected CAD SP-CMR or LGE ICA ≥50% DS 54% 28 4 3 22 - Falcao et al. () Brazil Level III-2 Low risk of bias N=42/57 patients with suspected CAD SP-CMR ICA ≥50% DS 60% 23 3 2 14 10/57 patients did not undergo CMR 2/57 had claustrophobia 2/57 had inadequate CMR images 1/57 patients had PCI. Kirschbaum et al. () The Netherlands Level III-2 Unclear risk of bias N=75 vessels from patients with stable angina and suspected CAD with normal LVEF SP-CMR MPR <1.8 MPR <1.9 MPR <2.0 Per artery FFR <0.8 NR 27 31 31 14 17 19 5 1 1 29 26 24 -
1237-AssessmentReport-Final.docx