Cochrane Library Quality: 23/27 multiple studies in the UK, comparing medical management types) Heartburn one study was conducted in with laparoscopic fundoplication Comparator: Regurgitation (acid reflux) 11 European countries, and surgery Medical management: either Dysphagia one study was conducted in Exclusion: PPIs or histamine receptor Other GORD-related symptoms a centre in Canada. Sample Non-randomised studies antagonists (H2RAs) Conversion to open surgery sizes ranged from 104 to Intraoperative complications 554 participants, with a total of 1,232 randomised Postoperative complications patients Admission to intensive treatment unit / unit Reoperation Mortality during index admission Medication use Length of operation Length of hospital stay Time off work Visits to GP due to GORD Visits to hospital due to GORD pH monitoring (% time pH <4 / DeMeester score) Manometry (LOS pressure) Endoscopy Other complications or adverse events False positives Study setting Study design Study population / Included Inclusion criteria / exclusion ‘True diagnosis’ and misdiagnosis Health outcomes assessed studies criteria
Cochrane Library Quality: 23/27 multiple studies in the UK, one study was conducted in 11 European countries, and one study was conducted in a centre in Canada. Sample sizes ranged from 104 to 554 participants, with a total of 1,232 randomised patients comparing medical management with laparoscopic fundoplication surgery Exclusion: Non-randomised studies types) Comparator: Medical management: either PPIs or histamine receptor antagonists (H2RAs) Heartburn Regurgitation (acid reflux) Dysphagia Other GORD-related symptoms Conversion to open surgery Intraoperative complications Postoperative complications Admission to intensive treatment unit / unit Reoperation Mortality during index admission Medication use Length of operation Length of hospital stay Time off work Visits to GP due to GORD Visits to hospital due to GORD pH monitoring (% time pH <4 / DeMeester score) Manometry (LOS pressure) Endoscopy Other complications or adverse events False positives Study setting Study design Study population / Included studies Inclusion criteria / exclusion criteria ‘True diagnosis’ and misdiagnosis Health outcomes assessed
1203-ContractedAssessmentReport-Catheter-free%20ambulatory%20pH%20test%20for%20GORD%20accessible.docx