the notified chemical was not a skin irritant Result: in rabbits Eye Irritation (Jackson & Ogilvie, 1993b) rabbit/New Zealand White Species/strain: 3/male Number/sex of animals: 6 days Observation period: 0.1 g of the notified chemical into the conjunctival Method of administration: sac of the right eye of each rabbit Draizea scores (Draize, 1959): no corneal effects (all Draize scores zero) except for dulling of corneal Cornea lustre in animal #1 and #2 at 1 hour, animals #1 and #3 at 48 hours and animal #3 at 72 hours slight iridal effects (Draize score of 1) up to and including 72 hours in all Iris animals except that animal #2 had no iridal effects at 72 hours but constriction of the pupil; no effects on days 4 - 6 Time after instillation Animal 1 hour 1 day 2 days 3 days 4 days 5 days 6 days see Attachment 1 for Draize scales a r = redness c = chemosis d = discharge, s = slight, m = moderate, t = OECD TG 405 Test method: the notified chemical was a moderate eye irritant Result: in rabbits
Result: the notified chemical was not a skin irritant in rabbits Eye Irritation (Jackson & Ogilvie, 1993b) Species/strain: rabbit/New Zealand White Number/sex of animals: 3/male Observation period: 6 days Method of administration: 0.1 g of the notified chemical into the conjunctival sac of the right eye of each rabbit Draizea scores (Draize, 1959): Cornea no corneal effects (all Draize scores zero) except for dulling of corneal lustre in animal #1 and #2 at 1 hour, animals #1 and #3 at 48 hours and animal #3 at 72 hours Iris slight iridal effects (Draize score of 1) up to and including 72 hours in all animals except that animal #2 had no iridal effects at 72 hours but constriction of the pupil; no effects on days 4 - 6 Time after instillation Animal 1 hour 1 day 2 days 3 days 4 days 5 days 6 days a see Attachment 1 for Draize scales r = redness c = chemosis d = discharge, s = slight, m = moderate, t = Test method: OECD TG 405 Result: the notified chemical was a moderate eye irritant in rabbits
NA662FR.docx