(24, 48, 72 hours Oedema: 1.3, 0, 0.3. observation): There were no signs of toxicity or ill health in any rabbit Comment: during the observation period. Well-defined erythema with or without very slight to slight oedema was seen in all three animals. Additionally, desquamation of the stratum corneum (characterised by dryness and sloughing of the skin) developed in all rabbits, and resolved completely by either Days 9, 10, or 13. The notified chemical was a moderate irritant to the skin of Result: rabbits. Eye Irritation (HLS, Rabbit/New Zealand White Species/strain: 3 females Number/sex of animals: 3 days Observation period: 0.1 mL of the notified chemical was placed into the Method of administration: everted lid and held in for one second. The contralateral eye served as control. OECD TG 405 Test method: Draize scores of unirrigated eyes: Time after instillation see Attachment 1 for Draize scales * r = redness c = chemosis d = discharge Mean individual (24, 48 and 72 hour Redness of the conjunctivae: 0.3, 0.3, 1; observation): Chemosis: 0, 0, 0. were no signs of toxicity or ill health in any rabbit Comment: during the observation period. No corneal damage or iridial
(24, 48, 72 hours observation): Oedema: 1.3, 0, 0.3. Comment: There were no signs of toxicity or ill health in any rabbit during the observation period. Well-defined erythema with or without very slight to slight oedema was seen in all three animals. Additionally, desquamation of the stratum corneum (characterised by dryness and sloughing of the skin) developed in all rabbits, and resolved completely by either Days 9, 10, or 13. Result: The notified chemical was a moderate irritant to the skin of rabbits. Eye Irritation (HLS, Species/strain: Rabbit/New Zealand White Number/sex of animals: 3 females Observation period: 3 days Method of administration: 0.1 mL of the notified chemical was placed into the everted lid and held in for one second. The contralateral eye served as control. Test method: OECD TG 405 Draize scores of unirrigated eyes: Time after instillation * see Attachment 1 for Draize scales r = redness c = chemosis d = discharge Mean individual (24, 48 and 72 hour observation): Redness of the conjunctivae: 0.3, 0.3, 1; Chemosis: 0, 0, 0. Comment: were no signs of toxicity or ill health in any rabbit during the observation period. No corneal damage or iridial
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