Necropsy day 22 of gestation Method of administration: gaseous in whole body exposure chambers Clinical observations: low incidence of maternal and foetal toxicity at 50 000 ppm, pre and post-implantation loss of foetuses and minor foetal defects such as parietal ossification and liver changes Maternal Mortality: none Test method: according to OECD Guidelines (15) Result: the notified chemical exhibited low developmental toxicity in rats exposed for 10 gestation days Development toxicity in the rabbit (18) Species/strain: rabbits/New Zealand White Number/sex of animals: 24 female for each dose Dose: 0, 5 000, 15 000 and 50 000 ppm 6 for 13 days Duration: (6-18 days of gestation) Necropsy: day 29 of gestation Method of administration: gaseous in whole body exposure chambers Clinical observations: maternal weight loss at 50 000 ppm for 45% of animals from days 8 to 10, recovered after day 10, no treatment related effects on foetuses evident at any dose, possibility of pre-implantation loss at all doses but incidence did not increase with dose Maternal Mortality: none Test method: according to OECD Guidelines (15)
Necropsy day 22 of gestation Method of administration: gaseous in whole body exposure chambers Clinical observations: low incidence of maternal and foetal toxicity at 50 000 ppm, pre and post-implantation loss of foetuses and minor foetal defects such as parietal ossification and liver changes Maternal Mortality: none Test method: according to OECD Guidelines (15) Result: the notified chemical exhibited low developmental toxicity in rats exposed for 10 gestation days Development toxicity in the rabbit (18) Species/strain: rabbits/New Zealand White Number/sex of animals: 24 female for each dose Dose: 0, 5 000, 15 000 and 50 000 ppm Duration: 6 for 13 days (6-18 days of gestation) Necropsy: day 29 of gestation Method of administration: gaseous in whole body exposure chambers Clinical observations: maternal weight loss at 50 000 ppm for 45% of animals from days 8 to 10, recovered after day 10, no treatment related effects on foetuses evident at any dose, possibility of pre-implantation loss at all doses but incidence did not increase with dose Maternal Mortality: none Test method: according to OECD Guidelines (15)
NA563FR.docx