7 days Observation period: 0.5 mL in a single, 4-hour, semi-occluded Method of administration: application Draize* scores (Draize, 1959): Time after Animal # treatment 1 2 3 (days) Erythema 1 hour 1 1 2 1 1 1 2 2 0 1 2 3 0 1 2 0d 0c 7 0 Oedema 1 hour 1 2 2 1 0 1 2 2 0 1 2 3 0 0 1 7 0 0 0 * see Attachment 1 for Draize scales; d = desquamation; c = crust formation OECD guideline TG404 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) the notified chemical was a slight to moderate skin Result: irritant in rabbits Eye Irritation (Miyamoto, 1992b) rabbit/Japanese albino Species/strain: 3/female (eye irrigated group) and 6/female (eye Number/sex of animals: unirrigated group) per test group 7 days Observation period: 100 mg of undiluted test substance or a 10% Method of administration: aqueous suspension into the conjunctival sac of the right eye; 30 seconds later the eyes of 3 rabbits
Observation period: 7 days Method of administration: 0.5 mL in a single, 4-hour, semi-occluded application Draize* scores (Draize, 1959): Time after Animal # treatment 1 2 3 (days) Erythema 1 hour 1 1 2 1 1 1 2 2 0 1 2 3 7 0 0 1 0d 2 0c Oedema 1 hour 1 2 2 1 0 1 2 2 0 1 2 3 0 0 1 7 0 0 0 * see Attachment 1 for Draize scales; d = desquamation; c = crust formation Test method: OECD guideline TG404 (Organisation for Economic Co-operation and Development, 1995- 1996) Result: the notified chemical was a slight to moderate skin irritant in rabbits Eye Irritation (Miyamoto, 1992b) Species/strain: rabbit/Japanese albino Number/sex of animals: 3/female (eye irrigated group) and 6/female (eye unirrigated group) per test group Observation period: 7 days Method of administration: 100 mg of undiluted test substance or a 10% aqueous suspension into the conjunctival sac of the right eye; 30 seconds later the eyes of 3 rabbits
NA645FR.docx