skin sensitisation guinea pig Non sensitiser (Glaza MS, 1993b) 9.1.1 Oral Toxicity (Glaza MS, 1993a) Rats/Crl:CD BR Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A single oral dose of 5000 mg/kg (0.5 g/mL in distilled Method of administration: water) was given by gavage OECD TG 401 (limit test) Test method: None Mortality: Red-stained urine, soft stool and haircoat Clinical observations: All animals had diffusely red tail and/or hair coat around the Morphological findings: perianal region. Microscopic investigation was not conducted in the All animals appeared normal by day 14 Comment: > 5000 mg/kg LD50: the notified chemical was of very low acute oral toxicity in Result: rats 9.1.2 Dermal Toxicity (Allen DJ, 1996) Rats/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A single dermal dose of 2000 mg/kg (moistened with Method of administration: distilled was applied under a semi-occlusive dressing for 24 hours OECD TG 402 (limit test) Test method: None Mortality: None Clinical observations:
skin sensitisation guinea pig Non sensitiser (Glaza MS, 1993b) 9.1.1 Oral Toxicity (Glaza MS, 1993a) Species/strain: Rats/Crl:CD BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A single oral dose of 5000 mg/kg (0.5 g/mL in distilled water) was given by gavage Test method: OECD TG 401 (limit test) Mortality: None Clinical observations: Red-stained urine, soft stool and haircoat Morphological findings: All animals had diffusely red tail and/or hair coat around the perianal region. Microscopic investigation was not conducted in the Comment: All animals appeared normal by day 14 LD50: > 5000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (Allen DJ, 1996) Species/strain: Rats/Sprague-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A single dermal dose of 2000 mg/kg (moistened with distilled was applied under a semi-occlusive dressing for 24 hours Test method: OECD TG 402 (limit test) Mortality: None Clinical observations: None
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