Conjunctival redness: 0.0 (24, 48 & 72 hour Conjunctival chemosis: 0.0 observation): Conjunctival redness was noted in 2 treated eyes at the Ocular effects, 1 hour observation; all treated eyes appeared normal at the Irrigated eyes: 24 hour observation; no iridial or conjunctival effects noted C20-24 Alkenes, branched and linear were very slightly Result: irritating to the eyes of rabbits. 9.1.6.5 Acute Eye Irritation of Other Alkenes The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate tests were not conducted in accordance with GLP or OECD or EC testing guidelines. In each case the following test substances were instilled into the eyes of New Zealand rabbits, without eye irrigation. The HEDSET documents reported each of the test substances as non-irritating. Test Substance Mean group score (24, 48 & 72 hour observation) Corneal Iridial Conjunctival Conjunctival opacity inflammation redness chemosis C12 C14H14 0.0 0.0 Draize Score = 3.0** – C12 - C26* 0.0 0.0 0.2 0.06 Olefin/ParaffinH18 C14 C16H14 0.0 0.0 Draize Score = 2.1** – C14 C18* OlefinH14 0.0 0.0 Draize Score = 2.7** – C14 C18* 0.0 0.0 0.22 0.4 – Olefin/ParaffinH18 C14 C26* OlefinH14 0.0 0.0 Draize Score = 2.7** – C14 C26* 0.0 0.0 0.1 0.3 – Olefin/ParaffinH18 C18 C24* OlefinsH18 0.0 0.0 0.5 0.6 – C18 C26* 0.0 0.0 0.2 0.3 – Olefin/ParaffinH18
(24, 48 & 72 hour observation): Conjunctival redness: 0.0 Conjunctival chemosis: 0.0 Ocular effects, Irrigated eyes: Conjunctival redness was noted in 2 treated eyes at the 1 hour observation; all treated eyes appeared normal at the 24 hour observation; no iridial or conjunctival effects noted Result: C20-24 Alkenes, branched and linear were very slightly irritating to the eyes of rabbits. 9.1.6.5 Acute Eye Irritation of Other Alkenes The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate tests were not conducted in accordance with GLP or OECD or EC testing guidelines. In each case the following test substances were instilled into the eyes of New Zealand rabbits, without eye irrigation. The HEDSET documents reported each of the test substances as non-irritating. Test Substance Mean group score (24, 48 & 72 hour observation) Corneal opacity Iridial inflammation Conjunctival redness Conjunctival chemosis C12 – C14H14 0.0 0.0 Draize Score = 3.0** C12 - C26* Olefin/ParaffinH18 0.0 0.0 0.2 0.06 C14 – C16H14 0.0 0.0 Draize Score = 2.1** C14 – C18* OlefinH14 0.0 0.0 Draize Score = 2.7** C14 – C18* Olefin/ParaffinH18 0.0 0.0 0.22 0.4 C14 – C26* OlefinH14 0.0 0.0 Draize Score = 2.7** C14 – C26* Olefin/ParaffinH18 0.0 0.0 0.1 0.3 C18 – C24* OlefinsH18 0.0 0.0 0.5 0.6 C18 – C26* Olefin/ParaffinH18 0.0 0.0 0.2 0.3
NA713FR.docx