Histopathology: rats killed following 28 days of dosing treatment-related findings in the ovary, liver and mesenteric lymph node were observed vacuolated cells were present in the of 6/10 treated rats; ovaries: corpora lutea granulomata were present in the of 4/10 treated rats; in total, 9/10 rats corpora lutea showed a histological change in the ovary granulomata in the liver of a single treated rat corresponding with the pale foci liver: noted macroscopically in this animal; for this reason the tissue was processed as an abnormality marked histiocytosis in the mesenteric lymph node of a single mesenteric lymph node: treated rat, corresponding with the enlargement noted macroscopically there was a higher incidence of luminal dilatation of the uterus in incidental findings: treated, but this was consistent with the stage of the oestrous cycle that they were in and is not considered likely to be related to treatment; treated rats were in a variety of different stages of the oestrous cycle, such as would normally be expected in rats of this age rats killed on day 20 of gestation there were vacuolated cells in the and granulomata in the ovaries: corpora lutea ovaries of the majority of treated rats there were granulomata in the livers of two treated rats (these livers were liver: processed due to the presence of macroscopic abnormalities). all findings were of a nature and incidence commonly found in rats of this age and strain, and were considered of no toxicological importance; there were no histological findings in tissues from the pair of rats that did not breed successfully to suggest any infertility Foetal observations: external observations at dissection, narrow and flattened heads were seen in 15/113 foetuses from 7/9 litters treated with the notified chemical; 27/113 treated foetuses were observed to have narrow heads and 13/113 flattened heads; this finding was not seen in the 125 control
Histopathology: rats killed following 28 days of dosing treatment-related findings in the ovary, liver and mesenteric lymph node were observed ovaries: vacuolated cells were present in the corpora lutea of 6/10 treated rats; granulomata were present in the corpora lutea of 4/10 treated rats; in total, 9/10 rats showed a histological change in the ovary liver: granulomata in the liver of a single treated rat corresponding with the pale foci noted macroscopically in this animal; for this reason the tissue was processed as an abnormality mesenteric lymph node: marked histiocytosis in the mesenteric lymph node of a single treated rat, corresponding with the enlargement noted macroscopically incidental findings: there was a higher incidence of luminal dilatation of the uterus in treated, but this was consistent with the stage of the oestrous cycle that they were in and is not considered likely to be related to treatment; treated rats were in a variety of different stages of the oestrous cycle, such as would normally be expected in rats of this age rats killed on day 20 of gestation ovaries: there were vacuolated cells in the corpora lutea and granulomata in the ovaries of the majority of treated rats liver: there were granulomata in the livers of two treated rats (these livers were processed due to the presence of macroscopic abnormalities). all findings were of a nature and incidence commonly found in rats of this age and strain, and were considered of no toxicological importance; there were no histological findings in tissues from the pair of rats that did not breed successfully to suggest any infertility Foetal observations: external observations at dissection, narrow and flattened heads were seen in 15/113 foetuses from 7/9 litters treated with the notified chemical; 27/113 treated foetuses were observed to have narrow heads and 13/113 flattened heads; this finding was not seen in the 125 control
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