Rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: Oral, (gavage) 5 050 mg/kg (dose volume of 5.92 mL/kg) Method of administration: OECD TG 420 fixed dose method Test method: – In life observations of note included diarrhoea, piloerection Clinical observations: and polyuria, which were no longer evident by Day 11. Nil Mortality: No abnormalities detected. Morphological findings: > 5 050 mg/kg LD50: C18 Isomerised Olefin was of very low acute oral toxicity in Result: rats. 9.1.1.5 Acute Oral Toxicity of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) C20-24 Alkenes, branched and linear Test Substance: Rat/Sprague Dawley Crl:CD BR Species/strain: 5/sex Number/sex of animals: 14 days Observation period: Oral, gavage 5 000 mg/kg (dose volume of 6.29 mL/kg) Method of administration: OECD TG 420 fixed dose method Test method: – Hunched posture and piloerection in all animals on day of Clinical observations: dosing; One female found dead one day after dosing Mortality: The female dead had haemorrhagic lungs, dark liver and Morphological findings: dark kidneys; No abnormalities detected at terminal kill. > 5 000 mg/kg LD50: C20-24 Alkenes, branched and linear was of very low acute Result: oral toxicity in rats.
Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, (gavage) 5 050 mg/kg (dose volume of 5.92 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: In life observations of note included diarrhoea, piloerection and polyuria, which were no longer evident by Day 11. Mortality: Nil Morphological findings: No abnormalities detected. LD50: > 5 050 mg/kg Result: C18 Isomerised Olefin was of very low acute oral toxicity in rats. 9.1.1.5 Acute Oral Toxicity of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) Test Substance: C20-24 Alkenes, branched and linear Species/strain: Rat/Sprague Dawley Crl:CD BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, gavage 5 000 mg/kg (dose volume of 6.29 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: Hunched posture and piloerection in all animals on day of dosing; Mortality: One female found dead one day after dosing Morphological findings: The female dead had haemorrhagic lungs, dark liver and dark kidneys; No abnormalities detected at terminal kill. LD50: > 5 000 mg/kg Result: C20-24 Alkenes, branched and linear was of very low acute oral toxicity in rats.
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