None. Comment: >2 000 mg/kg LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Edgar, 1999a) Rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A dermal dose of 2 000 mg/kg was applied under an Method of administration: occlusive dressing for 24 hours. OECD TG 402, limit test Test method: No deaths were recorded. Mortality: Red discharge from the nose was observed on Day 1. Clinical observations: No abnormalities were noted at necropsy. Morphological findings: None, Comment: > 2 000 mg/kg LD50: The notified chemical was of low dermal toxicity in rats. Result: 9.1.3 Inhalation Toxicity An inhalation toxicity study was not provided. 9.1.4 Skin Irritation (Edgar, 1999b) Rabbit/New Zealand White Species/strain: 3 females. Number/sex of animals: 7 days Observation period: A volume of 0.5 mL was applied under a semi-occlusive Method of administration: dressing for 4 hours. OECD TG 404 Test method:
Comment: None. LD50: >2 000 mg/kg Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Edgar, 1999a) Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A dermal dose of 2 000 mg/kg was applied under an occlusive dressing for 24 hours. Test method: OECD TG 402, limit test Mortality: No deaths were recorded. Clinical observations: Red discharge from the nose was observed on Day 1. Morphological findings: No abnormalities were noted at necropsy. Comment: None, LD50: > 2 000 mg/kg Result: The notified chemical was of low dermal toxicity in rats. 9.1.3 Inhalation Toxicity An inhalation toxicity study was not provided. 9.1.4 Skin Irritation (Edgar, 1999b) Species/strain: Rabbit/New Zealand White Number/sex of animals: 3 females. Observation period: 7 days Method of administration: A volume of 0.5 mL was applied under a semi-occlusive dressing for 4 hours. Test method: OECD TG 404
NA869FR.docx