5 0 0 0 0 6 0 0 0 0 Iris 1 0 0 0 0 No readings given 2 0 0 0 0 3 0 0 0 0 4 0 0 0 0 5 0 0 0 0 6 0 0 0 0 Conjunctiva r c d r c d r c d 1 3 3 3 3 3 3 Scores not given, but reported as corrosive, 2 2 2 2 2 2 2 irreversible damage to 3 3 2 2 3 2 2 the eye 4 3 2 2 3 2 2 5 3 2 2 3 2 2 6 3 3 2 3 3 2 1 see Attachment 1 for Draize scales o opacity, a area, r redness, c chemosis, d discharge Draize scoresa of non-irrigated eyes (continued): Test 3: VARISOFT 3690, 90% solids Time after Instillation Animal 1 day 2 days 3 days 4 days 7 days Cornea o a o a o a o a o a 1 1.5 4 2 4 3 1.5 4 2 2.5 2 E 100 E 100 E 75 E 75 E 50 2 4 1 4 1 4 1 4 1 3 4 E 100 E 100 E 100 E 100 E 100 3 4 1 4 1 3 2 3 3 3 2 E 100 E 100 E 60 E 100 E 10 L 4 1.5 3 2 2 2.5 2 2 1.5 2 1 E 100 E 60 E 40 E 30 E 10
5 0 0 0 0 6 0 0 0 0 Iris 1 0 0 0 0 No readings given 2 0 0 0 0 3 0 0 0 0 4 0 0 0 0 5 0 0 0 0 6 0 0 0 0 Conjunctiva r c d r c d r c d 1 3 3 3 3 3 3 Scores not given, but reported as corrosive, irreversible damage to the eye 2 2 2 2 2 2 2 3 3 2 2 3 2 2 4 3 2 2 3 2 2 5 3 2 2 3 2 2 6 3 3 2 3 3 2 1 see Attachment 1 for Draize scales o opacity, a area, r redness, c chemosis, d discharge Draize scoresa of non-irrigated eyes (continued): Test 3: VARISOFT 3690, 90% solids Time after Instillation Animal 1 day 2 days 3 days 4 days 7 days Cornea o a o a o a o a o a 1 1.5 E 100 4 2 E 100 4 3 E 75 1.5 4 E 75 2 2.5 E 50 2 2 4 E 100 1 4 E 100 1 4 E 100 1 4 E 100 1 3 E 100 4 3 4 E 100 1 4 E 100 1 3 E 60 2 3 E 100 L 3 3 E 10 2 4 1.5 E 100 3 2 E 60 2 2.5 E 40 2 2 E 30 1.5 2 E 10 1
NA500FR.docx