EEC method B1 Test method: > 5 000 mg/kg LD50: the test substance was of very low oral Result: toxicity in rats Shell Brake Fluid Dot 4 Super rat/Fischer 344 Species/strain: 5/sex Number/sex of animals: 14 days Observation period: undiluted test material by gavage Method of administration: hunched posture within 1 hour of dosing; other Clinical observations: isolated signs were lachrymation, abasia, lethargy, unkempt appearance and encrustation of the periorbital zone; recovery, as judged by external appearance and behaviour, was complete by day 3 none Mortality: none Morphological findings: OECD TG 401 Test method: > 5 000 mg/kg LD50: the test substance was of very low acute oral Result: toxicity in rats Dermal Toxicity (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 rat/Fischer 344 Species/strain: 5/sex Number/sex of animals: 14 days Observation period: single dose at 1.89 mL/kg,under occlusive dressing Method of administration: for 24 hours
Test method: EEC method B1 LD50: > 5 000 mg/kg Result: the test substance was of very low oral toxicity in rats Shell Brake Fluid Dot 4 Super Species/strain: rat/Fischer 344 Number/sex of animals: 5/sex Observation period: 14 days Method of administration: undiluted test material by gavage Clinical observations: hunched posture within 1 hour of dosing; other isolated signs were lachrymation, abasia, lethargy, unkempt appearance and encrustation of the periorbital zone; recovery, as judged by external appearance and behaviour, was complete by day 3 Mortality: none Morphological findings: none Test method: OECD TG 401 LD50: > 5 000 mg/kg Result: the test substance was of very low acute oral toxicity in rats Dermal Toxicity (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 Species/strain: rat/Fischer 344 Number/sex of animals: 5/sex Observation period: 14 days Method of administration: single dose at 1.89 mL/kg,under occlusive dressing for 24 hours
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