after dosing, the animals showed decreased spontaneous Clinical observations: activity, squatting posture and stilted gait; these signs were reversible after 4 to 6 hours no organ abnormalities were observed at necropsy Morphological findings: no effect on body weight gain was observed Comment: > 2000 mg/kg LD50: the notified chemical was of very low acute oral toxicity in Result: rats 9.1.2 Dermal Toxicity No test results were provided by the notifier. 9.1.3 Inhalation Toxicity No test results were provided by the notifier. 9.1.4 Skin Irritation (Kreiling, 1996) rabbit/New Zealand albino Species/strain: 3 female Number/sex of animals: 3 days Observation period: 0.5 mL test substance was applied to a clipped test site under Method of administration: semi-occlusive conditions for 4 hr OECD TG 404 Test method: no signs of irritation were observed at 30-60 minutes, 24 hr, Comment: 48 hr or 72 hr; all Draize scores were zero the notified chemical was not irritating to the skin of rabbits Result: 9.1.5 Eye Irritation (Kreiling, 1996) rabbit/New Zealand albino Species/strain: 3/not stated Number/sex of animals:
Clinical observations: after dosing, the animals showed decreased spontaneous activity, squatting posture and stilted gait; these signs were reversible after 4 to 6 hours Morphological findings: no organ abnormalities were observed at necropsy Comment: no effect on body weight gain was observed LD50: > 2000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity No test results were provided by the notifier. 9.1.3 Inhalation Toxicity No test results were provided by the notifier. 9.1.4 Skin Irritation (Kreiling, 1996) Species/strain: rabbit/New Zealand albino Number/sex of animals: 3 female Observation period: 3 days Method of administration: 0.5 mL test substance was applied to a clipped test site under semi-occlusive conditions for 4 hr Test method: OECD TG 404 Comment: no signs of irritation were observed at 30-60 minutes, 24 hr, 48 hr or 72 hr; all Draize scores were zero Result: the notified chemical was not irritating to the skin of rabbits 9.1.5 Eye Irritation (Kreiling, 1996) Species/strain: rabbit/New Zealand albino Number/sex of animals: 3/not stated
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