Oral Toxicity (Frank, 1996a) rat/Cr1:CD BR Species/strain: 5/sex Number/sex of animals: 14 days Observation period: oral (gavage) Method of administration: 2 females had anogenital staining at the 6 hour Clinical observations: after treatment nil Mortality: 1 female had a dilated pelvis Morphological findings: limit test, OECD TG 401 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) > 2 000 mg/kg LD50: PDN 1204 was of very low oral toxicity in Result: rats Dermal Toxicity (Frank, 1996b) rabbit/New Zealand White Species/strain: 5/sex Number/sex of animals: 14 days Observation period: dermal application of 2 000 mg/kg (3 to 3.5 mL) Method of administration: under occlusive dressing for 24 hours nil Clinical observations: nil Mortality: 1 male had an unthrifty coat and 1 female had Morphological findings: desquamation on the dose site
Oral Toxicity (Frank, 1996a) Species/strain: rat/Cr1:CD BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: oral (gavage) Clinical observations: 2 females had anogenital staining at the 6 hour after treatment Mortality: nil Morphological findings: 1 female had a dilated pelvis Test method: limit test, OECD TG 401 (Organisation for Economic Co-operation and Development, 1995- 1996) LD50: > 2 000 mg/kg Result: PDN 1204 was of very low oral toxicity in rats Dermal Toxicity (Frank, 1996b) Species/strain: rabbit/New Zealand White Number/sex of animals: 5/sex Observation period: 14 days Method of administration: dermal application of 2 000 mg/kg (3 to 3.5 mL) under occlusive dressing for 24 hours Clinical observations: nil Mortality: nil Morphological findings: 1 male had an unthrifty coat and 1 female had desquamation on the dose site
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