a single dose of 5 000 mg/kg administered by Method of administration: gavage; vehicle was 25% (w/w) corn oil decreased activity and diarrhoea was in one Clinical observations: male on day one of dose administration none Mortality: no abnormalities detected Morphological findings: similar to OECD guidelines limit test (7) Test method: – > 5 000 mg/kg LD50: the notified chemical was of very low acute oral Result: toxicity in rats Dermal Toxicity (2) rabbit/New Zealand White Species/strain: 5/sex Number/sex of animals: 15 days Observation period: a dose of 2 000 mg/kg was applied to an intact skin Method of administration: site and covered with semi-occlusive dressing; after 24 hours the dressing and residual test material were removed one male had soft stools on days 2 and 3; and one Clinical observations: female had anorexia from days 2 to 6 none Mortality: no abnormalities detected Morphological findings: similar to OECD guidelines (7) Test method: > 2 000 mg/kg LD50: the notified chemical was of low dermal toxicity in Result: rabbits
Method of administration: a single dose of 5 000 mg/kg administered by gavage; vehicle was 25% (w/w) corn oil Clinical observations: decreased activity and diarrhoea was in one male on day one of dose administration Mortality: none Morphological findings: no abnormalities detected Test method: similar to OECD guidelines – limit test (7) LD50: > 5 000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats Dermal Toxicity (2) Species/strain: rabbit/New Zealand White Number/sex of animals: 5/sex Observation period: 15 days Method of administration: a dose of 2 000 mg/kg was applied to an intact skin site and covered with semi-occlusive dressing; after 24 hours the dressing and residual test material were removed Clinical observations: one male had soft stools on days 2 and 3; and one female had anorexia from days 2 to 6 Mortality: none Morphological findings: no abnormalities detected Test method: similar to OECD guidelines (7) LD50: > 2 000 mg/kg Result: the notified chemical was of low dermal toxicity in rabbits
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