9.1.3. Acute Inhalation Toxicity (Carpenter, 1966) Silane A-1120 Test Substance: Rats, strain not specified Species/strain: 6 Number/sex of animals: Not stated Observation period: Saturated vapour pressure generated by spreading 50g Method of administration: of test substance over 200 cm2 area on a shallow tray placed near the top of a 120L glass chamber and sealed for 16 hours while a fan intermittently agitated the chamber atmosphere; rats were then introduced into the test chamber via a gasketed drawer type cage None observed Clinical observations: nil Mortality: unremarkable pathology: Not an established guideline method Test method: > saturated vapour concentration (not stated) LC50: Silane A-1120 was of low inhalation toxicity in Result: rabbits Skin Irritation (Stanton, Dow Corning X3-3541 Test Substance: rabbit/New Zealand White Species/strain: 4 male Number/sex of animals: 72 Observation period: Dow Corning X3-3541 (0.5 mL) was applied to intact Method of administration: skin under a semi-occlusive dressing for 4 hours All individual scores were zero for erythema and Draize scores: oedema OECD TG 404 Test method: Dow Corning X3-3541 was non irritating to rabbit Result: skin
9.1.3. Acute Inhalation Toxicity (Carpenter, 1966) Test Substance: Silane A-1120 Species/strain: Rats, strain not specified Number/sex of animals: 6 Observation period: Not stated Method of administration: Saturated vapour pressure generated by spreading 50g of test substance over 200 cm2 area on a shallow tray placed near the top of a 120L glass chamber and sealed for 16 hours while a fan intermittently agitated the chamber atmosphere; rats were then introduced into the test chamber via a gasketed drawer type cage Clinical observations: None observed Mortality: nil pathology: unremarkable Test method: Not an established guideline method LC50: > saturated vapour concentration (not stated) Result: Silane A-1120 was of low inhalation toxicity in rabbits Skin Irritation (Stanton, Test Substance: Dow Corning X3-3541 Species/strain: rabbit/New Zealand White Number/sex of animals: 4 male Observation period: 72 Method of administration: Dow Corning X3-3541 (0.5 mL) was applied to intact skin under a semi-occlusive dressing for 4 hours Draize scores: All individual scores were zero for erythema and oedema Test method: OECD TG 404 Result: Dow Corning X3-3541 was non irritating to rabbit skin
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