Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely 1 Very slight oedema (barely 1 perceptible) perceptible) Well-defined erythema 2 Slight oedema (edges of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 3 mm) Severe erythema (beet redness) 4 Severe oedema (raised more than 1 4 mm and extending beyond area of exposure) The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent no details of iris 3 visible, size of pupil barely Greater than 75% 4 moderate discernible Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely 1 Any swelling 1 slight Any amount different 1 slight injected above normal slight normal from normal More diffuse, deeper 2 mod. Obvious swelling 2 mild Discharge with 2 mod. crimson red with with partial eversion moistening of lids individual vessels not of lids and adjacent hairs easily discernible Swelling with lids 3 mod. Discharge with 3 Diffuse beefy red 3 half-closed moistening of lids severe severe and and Swelling with lids 4 considerable area half-closed to severe around eye completely closed IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely 1 perceptible) Well-defined erythema 2 Slight oedema (edges of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 3 mm) Severe erythema (beet redness) 4 Severe oedema (raised more than 1 4 mm and extending beyond area of exposure) The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible Easily visible translucent details of iris slightly obscure 1 slight 25% to 50% 2 2 mild 50% to 75% 3 Opalescent no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely 1 Any swelling 1 slight Any amount different 1 slight injected above normal slight normal from normal More diffuse, deeper 2 mod. Obvious swelling 2 mild Discharge with 2 mod. crimson red with with partial eversion moistening of lids individual vessels not of lids and adjacent hairs easily discernible Swelling with lids 3 mod. Discharge with 3 Diffuse beefy red 3 half-closed moistening of lids severe severe Swelling with lids 4 and and considerable area half-closed to completely closed severe around eye IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
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