Appendix The toxicological assessment of NBPT in NA/467 is reproduced here (NICNAS, 1997). A.1 Acute Toxicity Summary of the acute toxicity of NBPT Test Species Outcome Reference acute oral toxicity rat (M) LD50 > 4 200 mg/kg Allied Corporation, (in distilled water) 1984a oral toxicity rat (M/F) LD50 1 000-4 000 mg/kg Allied Corporation, (in propylene glycol) 1985 acute oral toxicity rat LD50 > 2 000 mg/kg North American (in olive oil) Science Associates, 1990a acute oral toxicity rat LD50 > 2 823 mg/kg , 1994a (87% NBPT in distilled water) acute dermal toxicity rabbit LD50 > 2 000 mg/kg North American Science Associates, 1990b acute dermal toxicity rabbit LD50 > 2 000 mg/kg Allied Corporation, 1984b acute dermal toxicity rabbit LD50 > 2 000 mg/kg , 1994b skin irritation rabbit not a classifiable irritant , 1994c eye irritation rabbit *irritant Corning , 1996d skin sensitisation guinea pig not classifiable as a Allied Corporation, dermal sensitiser 1984c * test substance AGROTAIN (25% notified chemical) A.1.1 Oral Toxicity (Allied Corporation, 1984a) Species/strain: Fischer 344 rats Number/sex of animals: 5M/dose (500, 2 100, 4 200 mg/kg) Observation period: 14 days Method of administration: gavage in distilled Clinical observations: none Mortality: nil Morphological findings: none Test method: in accordance with TSCA GLP Regulations, similar to OECD guidelines LD50: > 4 200 mg/kg
Appendix The toxicological assessment of NBPT in NA/467 is reproduced here (NICNAS, 1997). A.1 Acute Toxicity Summary of the acute toxicity of NBPT Test Species Outcome Reference acute oral toxicity (in distilled water) rat (M) LD50 > 4 200 mg/kg Allied Corporation, 1984a oral toxicity (in propylene glycol) rat (M/F) LD50 1 000-4 000 mg/kg Allied Corporation, 1985 acute oral toxicity (in olive oil) rat LD50 > 2 000 mg/kg North American Science Associates, 1990a acute oral toxicity (87% NBPT in distilled water) rat LD50 > 2 823 mg/kg , 1994a acute dermal toxicity rabbit LD50 > 2 000 mg/kg North American Science Associates, 1990b acute dermal toxicity rabbit LD50 > 2 000 mg/kg Allied Corporation, 1984b acute dermal toxicity rabbit LD50 > 2 000 mg/kg , 1994b skin irritation rabbit not a classifiable irritant , 1994c eye irritation rabbit *irritant Corning , 1996d skin sensitisation guinea pig not classifiable as a dermal sensitiser Allied Corporation, 1984c * test substance AGROTAIN (25% notified chemical) A.1.1 Oral Toxicity (Allied Corporation, 1984a) Species/strain: Fischer 344 rats Number/sex of animals: 5M/dose (500, 2 100, 4 200 mg/kg) Observation period: 14 days Method of administration: gavage in distilled Clinical observations: none Mortality: nil Morphological findings: none Test method: in accordance with TSCA GLP Regulations, similar to OECD guidelines LD50: > 4 200 mg/kg
N-n-butyl-thiophosphoric-triamide-NBPT-secondary-notification-assessment.docx