1,3-benzenedimethanamine, rather than the 24-28 % (w/w) in the notified chemical. The aqueous solution used in the test had a pH of 11.5. rat/Wistar Species/strain: Number/sex of animals: 14 days Observation period: gavage, 10 % (w/v) aqueous solution Method of administration: males: 415, 490, 578, 682, 805, 950 mg/kg Dose range: females: 490, 578, 682, 805, 950, mg/kg OECD TG 401 (Organisation for Economic Cooperation and Test method: Development, 1987) males Mortality: dose (mg/kg) mortality 0 (control) 0/10 415 0/10 490 2/10 578 4/10 682 3/10 805 9/10 950 10/10 females dose (mg/kg) mortality 0 (control) 0/10 490 0/10 578 1/10 682 4/10 805 7/10 950 8/10 1121 10/10 transient signs of excitement were observed in the animals Clinical observations: immediately administration; sudden collapse due to ataxia resulting in death was seen in a number of the animals, generally within two hours of administration and always within the first day; partial recovery from the symptoms was seen in the surviving animals by the second day
1,3-benzenedimethanamine, rather than the 24-28 % (w/w) in the notified chemical. The aqueous solution used in the test had a pH of 11.5. Species/strain: rat/Wistar Number/sex of animals: Observation period: 14 days Method of administration: gavage, 10 % (w/v) aqueous solution Dose range: males: 415, 490, 578, 682, 805, 950 mg/kg females: 490, 578, 682, 805, 950, mg/kg Test method: OECD TG 401 (Organisation for Economic Cooperation and Development, 1987) Mortality: males dose (mg/kg) mortality 0 (control) 0/10 415 0/10 490 2/10 578 4/10 682 3/10 805 9/10 950 10/10 females dose (mg/kg) mortality 0 (control) 0/10 490 0/10 578 1/10 682 4/10 805 7/10 950 8/10 1121 10/10 Clinical observations: transient signs of excitement were observed in the animals immediately administration; sudden collapse due to ataxia resulting in death was seen in a number of the animals, generally within two hours of administration and always within the first day; partial recovery from the symptoms was seen in the surviving animals by the second day
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