HeartMate® II8,9 200 (200) Continuous-flow MLHF — (2005–2007) LVAD versus KCCQ pulsatile flow LVAD A median improvement of 42 points at 24 months compared with baseline in the MHLF Both groups achieved a clinically meaningful (>5 points) improvement in KCCQ at 6 months, with no decline out to 24 months Placement of Aortic 699 (628) TAVI versus SAVR KCCQ Follow-up Transcatheter SF-12 questionnaires (PARTNER A) EQ-5D were collected (2007–2009)10,11 from >80% of The two groups surviving had similar QOL patients improvements at 12 months Placement of Aortic 358 (358) TAVI versus KCCQ QOL Transcatheter Valve medical therapy SF-12 questionnaires (PARTNER B) were completed (2007–2009)11 The for 84% of difference patients still at 1 year in the alive at KCCQ Overall 12 months Summary Scores was 26.0 points, in the SF-12 physical scale was 5.7 points, and in the SF-12 mental scale was 6.4 points, all in favour of TAVI CRT, cardiac resynchronization therapy; EQ-5D, EuroQol-5D; ICD, implantable cardioverter–defibrillator; KCCQ, Kansas City Cardiomyopathy Questionnaire; LVAD, left ventricular assist device; MLHF, Minnesota Living with Heart Failure Questionnaire; QOL, quality of life; SF, short form; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve implantation. Supplementary references 1. Abraham, W. T. et al. Cardiac resynchronization in chronic heart failure. N. Engl. J. Med. 346, 1845–1853 (2002).
HeartMate® II8,9 (2005–2007) 200 (200) Continuous-flow LVAD versus pulsatile flow LVAD MLHF KCCQ A median improvement of 42 points at 24 months compared with baseline in the MHLF Both groups achieved a clinically meaningful (>5 points) improvement in KCCQ at 6 months, with no decline out to 24 months — Placement of Aortic Transcatheter (PARTNER A) (2007–2009)10,11 699 (628) TAVI versus SAVR KCCQ SF-12 EQ-5D The two groups had similar QOL improvements at 12 months Follow-up questionnaires were collected from >80% of surviving patients Placement of Aortic Transcatheter Valve (PARTNER B) (2007–2009)11 358 (358) TAVI versus medical therapy KCCQ SF-12 The difference at 1 year in the KCCQ Overall Summary Scores was 26.0 points, in the SF-12 physical scale was 5.7 points, and in the SF-12 mental scale was 6.4 points, all in favour of TAVI QOL questionnaires were completed for 84% of patients still alive at 12 months CRT, cardiac resynchronization therapy; EQ-5D, EuroQol-5D; ICD, implantable cardioverter–defibrillator; KCCQ, Kansas City Cardiomyopathy Questionnaire; LVAD, left ventricular assist device; MLHF, Minnesota Living with Heart Failure Questionnaire; QOL, quality of life; SF, short form; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve implantation. Supplementary references 1. Abraham, W. T. et al. Cardiac resynchronization in chronic heart failure. N. Engl. J. Med. 346, 1845–1853 (2002).
nrcardio.2016.10-s4.docx