No treatment related changes were observed at necropsy. Morphological findings: Microscopic investigation was not conducted in the study. Purple coloured staining of the treatment site was in all Comment: animals which prevented accurate evaluation of erythema during the study. > 2000 mg/kg LD50: the notified chemical was of low dermal toxicity in rats Result: Inhalation Toxicity No report on inhalation toxicity was provided. 9.1.4 Skin Irritation (Glaza MS, 1992) Rabbits/New Zealand White Species/strain: 3/sex Number/sex of animals: 7 days Observation period: A single dermal dose of 0.5 g notified chemical (moistened Method of administration: with 0.9% saline) was applied under a semi-occlusive dressing for 4 hours OECD TG 404 Test method: Draize scores: Time Animal # treatment 1 2 3 4 5 6 (days) Erythema 1 2a,b,c 2b,c 1c 1c 1c 1c 2 2b,c 2b,c 1c 1c 1c 1c 3 2b,c 2b,c 1c 1c 1c 1c 4 1 1 0 1 1 0 7 0d 0d 0 0 0 0 Oedema 1 0 1 1 0 0 1
Morphological findings: No treatment related changes were observed at necropsy. Microscopic investigation was not conducted in the study. Comment: Purple coloured staining of the treatment site was in all animals which prevented accurate evaluation of erythema during the study. LD50: > 2000 mg/kg Result: the notified chemical was of low dermal toxicity in rats Inhalation Toxicity No report on inhalation toxicity was provided. 9.1.4 Skin Irritation (Glaza MS, 1992) Species/strain: Rabbits/New Zealand White Number/sex of animals: 3/sex Observation period: 7 days Method of administration: A single dermal dose of 0.5 g notified chemical (moistened with 0.9% saline) was applied under a semi-occlusive dressing for 4 hours Test method: OECD TG 404 Draize scores: Time Animal # treatment (days) 1 2 3 4 5 6 Erythema 1 2a,b,c 2b,c 1c 1c 1c 1c 2 2b,c 2b,c 1c 1c 1c 1c 3 2b,c 2b,c 1c 1c 1c 1c 4 1 1 0 1 1 0 7 0d 0d 0 0 0 0 Oedema 1 0 1 1 0 0 1
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