9.1.1 Oral Toxicity (Shepard, 1999c) rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: gavage; single dose of 2000 mg/kg of test substance as a Method of administration: 10 % (w/v) suspension in 0.5% carboxymethylcellulose vehicle OECD TG 401 Test method: no deaths were recorded during the study period Mortality: these were limited to discoloured (light brown) faeces from Clinical observations: all animals the day following dosing no treatment-related changes were observed at necropsy Morphological findings: body weight gain was not adversely affected over the Comment: observation period > 2000 mg/kg LD50: the notified chemical was of very low acute oral toxicity in Result: rats 9.1.2 Dermal Toxicity (Jessup, 1999) rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: single dose of 2000 mg/kg test substance, moistened in Method of administration: was administered under occlusive conditions on the dorsal skin for 24 hours OECD TG 402 Test method: no deaths were recorded during the study period Mortality: reduced amounts of faeces during days 4 - 7; minor Clinical observations: porphyrin discharge during days 4 - 13; weight loss during the first week of the study; each for a single male
9.1.1 Oral Toxicity (Shepard, 1999c) Species/strain: rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: gavage; single dose of 2000 mg/kg of test substance as a 10 % (w/v) suspension in 0.5% carboxymethylcellulose vehicle Test method: OECD TG 401 Mortality: no deaths were recorded during the study period Clinical observations: these were limited to discoloured (light brown) faeces from all animals the day following dosing Morphological findings: no treatment-related changes were observed at necropsy Comment: body weight gain was not adversely affected over the observation period LD50: > 2000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (Jessup, 1999) Species/strain: rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: single dose of 2000 mg/kg test substance, moistened in was administered under occlusive conditions on the dorsal skin for 24 hours Test method: OECD TG 402 Mortality: no deaths were recorded during the study period Clinical observations: reduced amounts of faeces during days 4 - 7; minor porphyrin discharge during days 4 - 13; weight loss during the first week of the study; each for a single male
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