B3. Details of New leads obtained, if any: Lead Molecule Biological Activity Test Model Target Protein Identified Anti cholesterogenic K562, A549, Homobrassinolide X Receptor and anti carcinogenic Hep3B ZINC08764498 Anticancer K562 BCR-ABL ZINC04654813 Anticancer MDA MB-231 AKT1 Piperine Antifertility Wistar Rat Androgenic receptors MDR cell lines developed Piperine analog A549 P-gp inhibition for testing Astaxanthin Antiaging Yeast cells Antioxidant proteins Licarin A Anticancer A549 Autophagy A549, K562, Curcumin Anticancer Gene expression analysis SW480 Sesamin Anticancer complex β-catenin/TCF4 Acylhomoserine D-alanine - D alanine A.baumannii Antimicrobial Lactone and synthetase S. aureus Probiotic in treatment of dental caries & as Lactobacillus Novel Bacterocins Antimicrobial preservative in Agro-food fermentum industry
B3. Details of New leads obtained, if any: Lead Molecule Identified Biological Activity Test Model Target Protein Homobrassinolide Anti cholesterogenic and anti carcinogenic K562, A549, Hep3B X Receptor ZINC08764498 Anticancer K562 BCR-ABL ZINC04654813 Anticancer MDA MB-231 AKT1 Piperine Antifertility Wistar Rat Androgenic receptors Piperine analog P-gp inhibition A549 MDR cell lines developed for testing Astaxanthin Antiaging Yeast cells Antioxidant proteins Licarin A Anticancer A549 Autophagy Curcumin Anticancer A549, K562, SW480 Gene expression analysis Sesamin Anticancer β-catenin/TCF4 complex Acylhomoserine Lactone Antimicrobial A.baumannii and S. aureus D-alanine - D alanine synthetase Novel Bacterocins Antimicrobial Lactobacillus fermentum Probiotic in treatment of dental caries & as preservative in Agro-food industry
NArumugam_PondiUniv_ComplRep2017_revreq.docx