Inhalation Toxicity No was provided by the notifier. Skin Irritation (Tuffnell, 1992c) rabbit/New Zealand Species/strain: 3 males Number/sex of animals: 72 hours Observation period: 0.5 g of the test material, moistened with 0.5 mL Method of administration: distilled was applied under a gauze patch for a period of 4 hours similar to OECD TG 404 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) one animal developed erythema and oedema (Draize, 1959) Draize scores (Draize score of 1) by the 24 hour reading; (see Attachment 1 for Draize scales): oedema had cleared by 48 and erythema had disappeared by day 7 the notified chemical is a slight irritant to the Result: skin of rabbits Eye Irritation (Tuffnell, 1992d) rabbit/New Zealand Species/strain: 3 males Number/sex of animals: 72 hours for two of the animals, 7 days for the Observation period: third animal. 0.1 mL of the test solution was placed into the Method of administration: conjunctival sac of the right eye; the left eye was used as a control; animals 2 and 3 were administered one drop of local anaesthetic into each eye 1-2 minutes before dosing
Inhalation Toxicity No was provided by the notifier. Skin Irritation (Tuffnell, 1992c) Species/strain: rabbit/New Zealand Number/sex of animals: 3 males Observation period: 72 hours Method of administration: 0.5 g of the test material, moistened with 0.5 mL distilled was applied under a gauze patch for a period of 4 hours Test method: similar to OECD TG 404 (Organisation for Economic Co-operation and Development, 1995- 1996) Draize scores (Draize, 1959) (see Attachment 1 for Draize scales): one animal developed erythema and oedema (Draize score of 1) by the 24 hour reading; oedema had cleared by 48 and erythema had disappeared by day 7 Result: the notified chemical is a slight irritant to the skin of rabbits Eye Irritation (Tuffnell, 1992d) Species/strain: rabbit/New Zealand Number/sex of animals: 3 males Observation period: 72 hours for two of the animals, 7 days for the third animal. Method of administration: 0.1 mL of the test solution was placed into the conjunctival sac of the right eye; the left eye was used as a control; animals 2 and 3 were administered one drop of local anaesthetic into each eye 1-2 minutes before dosing
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