Skin Irritation (Carpenter, 1966) Silane A-1120 Test Substance: rabbit/New Zealand White Species/strain: 5 animals, sex not stated Number/sex of animals: applied in 0.1 mL amounts to clipped, intact skin of Method of the belly either undiluted or in progressive dilutions of administration/Dermal 10, 1, 0.1 or 0.01% solvent. Ten grades are recognised response evaluation : based on appearance of moderate or marked capillary injection, erythema, oedema, necrosis within 24 hours. Test substance Grade 1 = No injury from undiluted. Moderate erythema on one animal and from moderate Response: to marked capillary injection on four others. Grade 3. (No individual scores provided) Not stated Test method: Silane A-1120 was moderately irritating to rabbit skin Result: Eye Irritation (Stanton, 1990b) Dow Corning X3-3541 Test Substance: rabbit/New Zealand White Species/strain: 3 male/group Number/sex of animals: 14 days (group 1), Observation period: 7 days 2). Dow Corning X3-3541 (0.1 mL) was instilled into the Method of administration: right eye of each rabbit. Group 1 eyes were dosed and not washed. Group 2 eyes were dosed and washed 30 seconds after treatment. similar to OECD TG 405 Test method:
Skin Irritation (Carpenter, 1966) Test Substance: Silane A-1120 Species/strain: rabbit/New Zealand White Number/sex of animals: 5 animals, sex not stated Method of administration/Dermal response evaluation : Test substance applied in 0.1 mL amounts to clipped, intact skin of the belly either undiluted or in progressive dilutions of 10, 1, 0.1 or 0.01% solvent. Ten grades are recognised based on appearance of moderate or marked capillary injection, erythema, oedema, necrosis within 24 hours. Grade 1 = No injury from undiluted. Response: Moderate erythema on one animal and from moderate to marked capillary injection on four others. Grade 3. (No individual scores provided) Test method: Not stated Result: Silane A-1120 was moderately irritating to rabbit skin Eye Irritation (Stanton, 1990b) Test Substance: Dow Corning X3-3541 Species/strain: rabbit/New Zealand White Number/sex of animals: 3 male/group Observation period: 14 days (group 1), 7 days 2). Method of administration: Dow Corning X3-3541 (0.1 mL) was instilled into the right eye of each rabbit. Group 1 eyes were dosed and not washed. Group 2 eyes were dosed and washed 30 seconds after treatment. Test method: similar to OECD TG 405
NA648FR.docx