no abnormalities were noted for animals that Morphological findings: survived the dosing; the animal that died on the day of dosing had haemorrhagic lungs, dark liver, dark kidneys and haemorrhage of the gastric mucosa similar to OECD TG 401 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) > 2 000 mg.kg-1 LD50: the notified chemical is of low acute oral toxicity Result: in rats Dermal Toxicity (Tuffnell, 1992b) rat/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: dose of 2 000 mg.kg-1 of the notified chemical was Method of administration: applied to an area of shaved skin for 24 hours under an occlusive dressing no signs of systemic toxicity were observed; Clinical observations: desquamation was noted at the treatment sites of four females three to six days after dosing and persisted in two females seven days after dosing nil Mortality: nil Morphological findings: similar to OECD TG 402 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) > 2 000 mg.kg-1 LD50: the notified chemical is of low toxicity when Result: applied dermally to rats
Morphological findings: no abnormalities were noted for animals that survived the dosing; the animal that died on the day of dosing had haemorrhagic lungs, dark liver, dark kidneys and haemorrhage of the gastric mucosa Test method: similar to OECD TG 401 (Organisation for Economic Co-operation and Development, 1995- 1996) LD50: > 2 000 mg.kg-1 Result: the notified chemical is of low acute oral toxicity in rats Dermal Toxicity (Tuffnell, 1992b) Species/strain: rat/Sprague-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: dose of 2 000 mg.kg-1 of the notified chemical was applied to an area of shaved skin for 24 hours under an occlusive dressing Clinical observations: no signs of systemic toxicity were observed; desquamation was noted at the treatment sites of four females three to six days after dosing and persisted in two females seven days after dosing Mortality: nil Morphological findings: nil Test method: similar to OECD TG 402 (Organisation for Economic Co-operation and Development, 1995- 1996) LD50: > 2 000 mg.kg-1 Result: the notified chemical is of low toxicity when applied dermally to rats
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