9.1.1 Oral Toxicity (Kern, 1999e) rat/Crl:CD(SD)IGS BR Species/strain: 5/sex/dose Number/sex of animals: 14 days Observation period: gavage, dose levels 1183, 1538 and 2000 mg/kg; notified Method of administration: chemical administered as a suspension in corn oil; dose volume 20 mL/kg; dose administered in two halves given 4 hr apart OECD TG 401 Test method: 1183 mg/kg 1/10 Mortality: 1538 mg/kg 2/10 2000 mg/kg 2/10 one female in the 1183 mg/kg died prior to administration of the second half of the dose; the other premature decedents died within 2 days of dosing 29 animals showed discoloured areas due to discharges or Clinical observations: excretions (clear, red, yellow or brown) around the nose, mouth, hindlimbs, dorsal rump, ventral trunk, anogenital and/or urogenital area; 27 animals showed abnormalities in excretion (mucoid faeces, soft faeces and/or diarrhoea); hypoactivity was observed in six animals, predominantly in the 2000 mg/kg group prostration, hypothermia and laboured respiration were noted in two of the animals which later died other observations in one or two animals included impaired muscle coordination, clear ocular discharge, swollen nose and hair loss all observations with the exception of hair loss in one animal (till the end) and soft faeces in one animal on day 10 had cleared by day 6 no significant body weight changes were observed Body weight: three premature decedents had yellow stomach contents, one Morphological findings: of these had dark red lungs; no other gross pathological abnormalities were observed in these animals or at scheduled necropsy significant toxicity was observed at all doses tested Comment:
9.1.1 Oral Toxicity (Kern, 1999e) Species/strain: rat/Crl:CD(SD)IGS BR Number/sex of animals: 5/sex/dose Observation period: 14 days Method of administration: gavage, dose levels 1183, 1538 and 2000 mg/kg; notified chemical administered as a suspension in corn oil; dose volume 20 mL/kg; dose administered in two halves given 4 hr apart Test method: OECD TG 401 Mortality: 1183 mg/kg 1/10 1538 mg/kg 2/10 2000 mg/kg 2/10 one female in the 1183 mg/kg died prior to administration of the second half of the dose; the other premature decedents died within 2 days of dosing Clinical observations: 29 animals showed discoloured areas due to discharges or excretions (clear, red, yellow or brown) around the nose, mouth, hindlimbs, dorsal rump, ventral trunk, anogenital and/or urogenital area; 27 animals showed abnormalities in excretion (mucoid faeces, soft faeces and/or diarrhoea); hypoactivity was observed in six animals, predominantly in the 2000 mg/kg group prostration, hypothermia and laboured respiration were noted in two of the animals which later died other observations in one or two animals included impaired muscle coordination, clear ocular discharge, swollen nose and hair loss all observations with the exception of hair loss in one animal (till the end) and soft faeces in one animal on day 10 had cleared by day 6 Body weight: no significant body weight changes were observed Morphological findings: three premature decedents had yellow stomach contents, one of these had dark red lungs; no other gross pathological abnormalities were observed in these animals or at scheduled necropsy Comment: significant toxicity was observed at all doses tested
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