5/sex Number/sex of animals: 14 days Observation period: the notified chemical, a viscous liquid, was spread Method of administration: evenly over an area of approximately 25 cm2 and covered with an occlusive dressing for 24 hours no of systemic reaction to treatment; well Clinical observations: defined erythema in nine rats, slight erythema in one rat and slight oedema in male rats were observed on day 2; all animals recovered by day 5 none Mortality: none Morphological findings: Directive 84/449/EEC (OJ No. L251) Part B Test method: Method B.3 (European Economic Community, 1984) > 2 000 mg/kg LD50: the notified chemical was of low acute dermal Result: toxicity in rats Inhalation Toxicity (Jackson, 1994) rat/Sprague-Dawley Species/strain: 5/sex (test and control groups) Number/sex of animals: 14 days Observation period: 5.32 mg/L Dose(Exposure Concentration) snout only exposure to (liquid) aerosol (87% within Method of administration: respirable range) for 4 hours a soiled appearance of the fur was noted on day 0 Clinical observations: for test and control animals; exaggerated respiratory movements, staggering gait and poor grooming noted up to day 3; brown staining around the snout, jaws and around the eyes were persistent after day 3; food consumption of the test group slightly reduced on day 1 none Mortality:
Number/sex of animals: 5/sex Observation period: 14 days Method of administration: the notified chemical, a viscous liquid, was spread evenly over an area of approximately 25 cm2 and covered with an occlusive dressing for 24 hours Clinical observations: no of systemic reaction to treatment; well defined erythema in nine rats, slight erythema in one rat and slight oedema in male rats were observed on day 2; all animals recovered by day 5 Mortality: none Morphological findings: none Test method: Directive 84/449/EEC (OJ No. L251) Part B Method B.3 (European Economic Community, 1984) LD50: > 2 000 mg/kg Result: the notified chemical was of low acute dermal toxicity in rats Inhalation Toxicity (Jackson, 1994) Species/strain: rat/Sprague-Dawley Number/sex of animals: 5/sex (test and control groups) Observation period: 14 days Dose(Exposure Concentration) 5.32 mg/L Method of administration: snout only exposure to (liquid) aerosol (87% within respirable range) for 4 hours Clinical observations: a soiled appearance of the fur was noted on day 0 for test and control animals; exaggerated respiratory movements, staggering gait and poor grooming noted up to day 3; brown staining around the snout, jaws and around the eyes were persistent after day 3; food consumption of the test group slightly reduced on day 1 Mortality: none
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