OECD TG 401 Test method: None. Mortality: Ataxia, decreased activity, soft stool, wet yellow belly and Clinical observations: diarrhea on days 1 and 2. Not Morphological findings: > 5 000 mg/kg LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Reagan, & Parent, 1981b) Rabbit/New Zealand (NZW). Species/strain: 5/sex Number/sex of animals: 14 days Observation period: Under occlusive dressing for 24 hours at a dose of 2g/kg on Method of administration: abraded and intact skin. Similar to OECD TG 402. Test method: One animal died on day 7. Mortality: From day 11 scattered observations of diarrhea, soft stool Clinical observations: and loss of appetite. None given. Morphological findings: > 2 000 mg/kg LD50: the notified chemical was of low dermal toxicity in rats Result: 9.1.3 Inhalation Toxicity Not provided. 9.1.4 Skin Irritation (Reagan, Becci & Parent, 1981c) Rabbit/NZW Species/strain: 6/males. Number/sex of animals:
Test method: OECD TG 401 Mortality: None. Clinical observations: Ataxia, decreased activity, soft stool, wet yellow belly and diarrhea on days 1 and 2. Morphological findings: Not LD50: > 5 000 mg/kg Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Reagan, & Parent, 1981b) Species/strain: Rabbit/New Zealand (NZW). Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Under occlusive dressing for 24 hours at a dose of 2g/kg on abraded and intact skin. Test method: Similar to OECD TG 402. Mortality: One animal died on day 7. Clinical observations: From day 11 scattered observations of diarrhea, soft stool and loss of appetite. Morphological findings: None given. LD50: > 2 000 mg/kg Result: the notified chemical was of low dermal toxicity in rats 9.1.3 Inhalation Toxicity Not provided. 9.1.4 Skin Irritation (Reagan, Becci & Parent, 1981c) Species/strain: Rabbit/NZW Number/sex of animals: 6/males.
NA835FR.docx