9.1.1 Oral Toxicity (Chida T, 1992) rats/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: Dose: 2 000 mg/kg 14 days Observation period: 10 mL/kg of test substance in 0.5% 80, Method of administration: in 0.5% carboxymethylcellulose (CMC)-sodium aqueous solution by gavage Japanese Ministry of Health and Welfare (Japanese Test method: Ministry of Health and Welfare, 1989) no signs of systemic toxicity Clinical observations: nil Mortality: none Morphological findings: > 2 000 mg/kg LD50: the notified chemical was of very low oral Result: toxicity in rats 9.1.2 Dermal Toxicity (Allan SA, 1992) rat/Sprague-Dawley Crl.CD (SD) BR VAF Species/strain: 5/sex Number/sex of animals: 14 days Observation period: 2 000 mg/kg Dose: 2.14 mL/kg of test substance administered as Method of administration: supplied and held under occlusive dressing; after 24 hours, the treated area was washed with warm water and blotted dry with absorbent paper. EEC Directive 84/449/EEC, Annex V, Method B3 Test method: (European Economic Community (EEC), 1993a)
9.1.1 Oral Toxicity (Chida T, 1992) Species/strain: Number/sex of animals: Dose: Observation period: Method of administration: rats/Sprague-Dawley 5/sex 2 000 mg/kg 14 days 10 mL/kg of test substance in 0.5% 80, in 0.5% carboxymethylcellulose (CMC)-sodium aqueous solution by gavage Test method: Japanese Ministry of Health and Welfare (Japanese Ministry of Health and Welfare, 1989) Clinical observations: no signs of systemic toxicity Mortality: nil Morphological findings: none LD50: > 2 000 mg/kg Result: the notified chemical was of very low oral toxicity in rats 9.1.2 Dermal Toxicity (Allan SA, 1992) Species/strain: rat/Sprague-Dawley Crl.CD (SD) BR VAF Number/sex of animals: 5/sex Observation period: 14 days Dose: 2 000 mg/kg Method of administration: 2.14 mL/kg of test substance administered as supplied and held under occlusive dressing; after 24 hours, the treated area was washed with warm water and blotted dry with absorbent paper. Test method: EEC Directive 84/449/EEC, Annex V, Method B3 (European Economic Community (EEC), 1993a)
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