Category B Breeding or No more than Pain or distress Pain or distress or potential Holding Colony momentary or slight appropriately relieved pain or distress that is not Protocols pain or distress and with anesthetics, relieved with anesthetics, no use of analgesics and/or analgesics and/or tranquilizer relieving drugs, or no tranquilizer or other drugs or other methods for pain or distress. For methods for relieving pain or distress. example: pain or distress. Examples Examples Examples euthanatized for Holding or Diagnostic procedures Toxicological or tissues; just observed under normal weighing animals such as laparoscopy or microbiological testing, conditions; positive in teaching or needle biopsies. cancer research or reward projects; research Non-survival surgical infectious disease routine procedures; activities. procedures. research that requires injections; and blood Injections, blood Survival surgical continuation until clinical sampling. collection or procedures. symptoms are evident or catheter Post-operative pain or death occurs. implantation via distress. Ocular or skin irritancy superficial Ocular collection testing. vessels. in mice. Food or water deprivation Tattooing Terminal cardiac beyond that necessary for animals. blood collection. ordinary pre-surgical Ear punching of Any post procedural preparation. rodents. outcome resulting in Application of noxious Routine physical evident pain, stimuli such as electrical examinations. discomfort or distress shock if the animal cannot Observation of such as that avoid/escape the stimuli animal behavior. associated with and/or it is severe enough Feeding studies, decreased appetite/ to cause injury or more which do not activity level, adverse than momentary pain or result in clinical reactions, to touch, distress. health problems. open skin lesions, Infliction of or AVMA approved abscesses, lameness, trauma. humane conjunctivitis, corneal Prolonged restraint. euthanasia edema and Any procedures for procedures. photophobia. needed analgesics, Routine Exposure of blood tranquilizers, sedatives, or agricultural vessels for catheter anesthetics must be husbandry implantation. withheld for justifiable procedures. Exsanguination under study purposes. trapping. anesthesia. Use of paralyzing or reward Induced infections immobilizing drugs for projects. or antibody restraint.
Category B Breeding or Holding Colony Protocols No more than momentary or slight pain or distress and no use of drugs, or no pain or distress. For example: euthanatized for tissues; just observed under normal conditions; positive reward projects; routine procedures; injections; and blood sampling. Pain or distress appropriately relieved with anesthetics, analgesics and/or tranquilizer or other methods for relieving pain or distress. Pain or distress or potential pain or distress that is not relieved with anesthetics, analgesics and/or tranquilizer drugs or other methods for relieving pain or distress. Examples Examples Examples Holding or weighing animals in teaching or research activities. Injections, blood collection or catheter implantation via superficial vessels. Tattooing animals. Ear punching of rodents. Routine physical examinations. Observation of animal behavior. Feeding studies, which do not result in clinical health problems. AVMA approved humane euthanasia procedures. Routine agricultural husbandry procedures. trapping. reward projects. Diagnostic procedures such as laparoscopy or needle biopsies. Non-survival surgical procedures. Survival surgical procedures. Post-operative pain or distress. Ocular collection in mice. Terminal cardiac blood collection. Any post procedural outcome resulting in evident pain, discomfort or distress such as that associated with decreased appetite/ activity level, adverse reactions, to touch, open skin lesions, abscesses, lameness, conjunctivitis, corneal edema and photophobia. Exposure of blood vessels for catheter implantation. Exsanguination under anesthesia. Induced infections or antibody Toxicological or microbiological testing, cancer research or infectious disease research that requires continuation until clinical symptoms are evident or death occurs. Ocular or skin irritancy testing. Food or water deprivation beyond that necessary for ordinary pre-surgical preparation. Application of noxious stimuli such as electrical shock if the animal cannot avoid/escape the stimuli and/or it is severe enough to cause injury or more than momentary pain or distress. Infliction of or trauma. Prolonged restraint. Any procedures for needed analgesics, tranquilizers, sedatives, or anesthetics must be withheld for justifiable study purposes. Use of paralyzing or immobilizing drugs for restraint.
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