fatigue management courses11 Fatigue Review of 38 studies Exercise and Literature review of variety of exercise behavior change and behavioral interventions are change effective in managing interventions12 MS fatigue Fatigue, impairment, Resistance-, Beneficial effects and Literature review disability and QoL endurance-, and improved QoL combined training13 Impairment, Varied exercise Helpful in managing Literature review disability and QoL protocols14 symptoms, preventing complications and comorbidities, and may have neuroprotective effects. Impairment, Inpatient physical Improved functional Randomized, disability and QoL rehabilitation15 independence, controlled trial disability and QoL Disability and QoL Robot-assisted and Both types of Randomized, conventional BWSTT may controlled trial improve QoL and treadmill training decrease overall (BWSTT)16 disability. Cognitive Cognitive Promising for Randomized, dysfunction rehabilitation improving cognitive controlled trial intervention17 function Intervention target Intervention Outcome Study Design Cognitive Treadmill walking, Treadmill walking Randomized, dysfunction cycle ergometer, has a beneficial effect controlled trial guided yoga18 on executive function Cognitive Cognitive retraining Improves day-to-day Review article dysfunction treatment strategies19 performance Cognitive Exercise intervention Significant Systematic review dysfunction programs. Includes improvements in and meta-analysis review of 12 cognition were found controlled clinical in 9 of 12 studies. trials20 Depression Cognitive behavioral Face-to-face CBT is Single-group pilot therapy (CBT)21 feasible for use in feasibility study decreasing depressive symptoms
fatigue management courses11 Fatigue Review of 38 studies of variety of exercise and behavioral change interventions12 Exercise and behavior change interventions are effective in managing MS fatigue Literature review Fatigue, impairment, disability and QoL Resistance-, endurance-, and combined training13 Beneficial effects and improved QoL Literature review Impairment, disability and QoL Varied exercise protocols14 Helpful in managing symptoms, preventing complications and comorbidities, and may have neuroprotective effects. Literature review Impairment, disability and QoL Inpatient physical rehabilitation15 Improved functional independence, disability and QoL Randomized, controlled trial Disability and QoL Robot-assisted and conventional treadmill training (BWSTT)16 Both types of BWSTT may improve QoL and decrease overall disability. Randomized, controlled trial Cognitive dysfunction Cognitive rehabilitation intervention17 Promising for improving cognitive function Randomized, controlled trial Intervention target Intervention Outcome Study Design Cognitive dysfunction Treadmill walking, cycle ergometer, guided yoga18 Treadmill walking has a beneficial effect on executive function Randomized, controlled trial Cognitive dysfunction Cognitive retraining treatment strategies19 Improves day-to-day performance Review article Cognitive dysfunction Exercise intervention programs. Includes review of 12 controlled clinical trials20 Significant improvements in cognition were found in 9 of 12 studies. Systematic review and meta-analysis Depression Cognitive behavioral therapy (CBT)21 Face-to-face CBT is feasible for use in decreasing depressive symptoms Single-group pilot feasibility study
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