Name Mus musculus Suitability as a GM recipient It is a genetic model organism with a well-known, fully-sequenced genome. As a mammal its genome is very similar to that of humans. Mice are small so are cheap to feed and house. Many GM techniques applicable to humans or farm mammals are first tried on mice. Fluorescent GM NeonMice are sold as pets in the USA. Name Homo sapiens Human Suitability as a GM recipient People suffering from genetic diseases caused by two recessive non-functional alleles can be treated with gene therapy. The dominant functional allele is inserted into affected somatic Trials have included treatment of cystic fibrosis and Leber’s congenital amaurosis. The limitation on treating a human with another human allele is whether the cells that need the foreign DNA are accessible (eg lung epithelium) and stable (not replaced every few days).
Name Mus musculus Suitability as a GM recipient It is a genetic model organism with a well-known, fully-sequenced genome. As a mammal its genome is very similar to that of humans. Mice are small so are cheap to feed and house. Many GM techniques applicable to humans or farm mammals are first tried on mice. Fluorescent GM NeonMice are sold as pets in the USA. Name Homo sapiens Human Suitability as a GM recipient People suffering from genetic diseases caused by two recessive non-functional alleles can be treated with gene therapy. The dominant functional allele is inserted into affected somatic Trials have included treatment of cystic fibrosis and Leber’s congenital amaurosis. The limitation on treating a human with another human allele is whether the cells that need the foreign DNA are accessible (eg lung epithelium) and stable (not replaced every few days).
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