Supplementary Table 1 List of the top 500 differently expressed genes between wild – type and cultures. Table is provided in an attached Microsoft Excel file. Moz-/- Supplementary 2 List of the top 500 differently expressed genes between wild – type and cultures. Table is provided in an attached Microsoft Excel file. Moz+/- Supplementary Table 3 List of the top 500 differently expressed genes in a dose – dependent manner i.e. genes that are different between wild type and cultures Moz-/- – and show intermediate expression in cultures. Table is provided in an attached Moz+/- Microsoft Excel file. Supplementary Table 4 List of Broad Institute datasets that significantly correlate – with the dataset. The list of genes significantly changed in a dependent’ Moz ‘dose manner (Supplementary Table 3) was compared to differentially expressed genes in the datasets provided by the Broad Institute. Table is provided in an attached Microsoft Excel file. Supplementary Figure 6 Western blot analysis of passage 3 wild type and – Moz-/- MEFs grown at 20% O2. Protein levels of senescence marker and mediator p16INK4A were increased as early as passage 3 in MEFs compared to wild type. In contrast, p15INK4B, p21 and p53 Moz-/- levels were unchanged. Treatment with doxorubicin, which induces DNA damage and cell death, is provided as a positive control for p53. These data are consistent with
Supplementary Table 1 – List of the top 500 differently expressed genes between wild type and Moz-/- cultures. Table is provided in an attached Microsoft Excel file. Supplementary 2 – List of the top 500 differently expressed genes between wild type and Moz+/- cultures. Table is provided in an attached Microsoft Excel file. Supplementary Table 3 – List of the top 500 differently expressed genes in a dose dependent manner – i.e. genes that are different between wild type and Moz-/- cultures and show intermediate expression in Moz+/- cultures. Table is provided in an attached Microsoft Excel file. Supplementary Table 4 – List of Broad Institute datasets that significantly correlate with the Moz dataset. The list of genes significantly changed in a ‘dose dependent’ manner (Supplementary Table 3) was compared to differentially expressed genes in the datasets provided by the Broad Institute. Table is provided in an attached Microsoft Excel file. Supplementary Figure 6 – Western blot analysis of passage 3 wild type and Moz-/- MEFs grown at 20% O2. Protein levels of senescence marker and mediator p16INK4A were increased as early as passage 3 in Moz-/- MEFs compared to wild type. In contrast, p15INK4B, p21 and p53 levels were unchanged. Treatment with doxorubicin, which induces DNA damage and cell death, is provided as a positive control for p53. These data are consistent with
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