Dermal Toxicity (Budd, 1967) Study No. 1 rabbit/albino Species/strain: 2/sex Number/sex of animals: 28 days Observation period: polyethylene wrap for 24 hours Method of administration: moderate erythema on the skin of all four rabbits and Clinical observations: severe oedema, particularly in the abdominal ulceration and inflammation in the most severely affected areas during the first 14 days after treatment; scar formation during the last 14 days None Mortality: None Morphological findings: as described in 16 CFR 1500.40 Test method: > 2 000 mg/kg LD50: the notified chemical was of low acute dermal toxicity Result: in rabbits and may be a severe skin irritant (Heenehan et al., 1977a) No. 2 rabbit/New Zealand White Species/strain: 1/sex/dose group Number/sex of animals: 14 days Observation period: occlusive dressing for 24 hours; test substance as Method of administration: an aqueous slurry at 200 mg/kg, 500 mg/kg and 2 000 mg/kg on abraded and non abraded skin slight erythema was observed in one animal (500 mg/kg) Clinical observations: and severe erythema was observed in the remaining five animals following dressing removal; slight oedema was observed in one animal (500 mg/kg), moderate oedema was observed in 4 animals and severe oedema in one animal (2 000 mg/kg); lethargy was noted in one animal during the first 24 hours following compound
Dermal Toxicity Study No. 1 (Budd, 1967) Species/strain: rabbit/albino Number/sex of animals: 2/sex Observation period: 28 days Method of administration: polyethylene wrap for 24 hours Clinical observations: moderate erythema on the skin of all four rabbits and severe oedema, particularly in the abdominal ulceration and inflammation in the most severely affected areas during the first 14 days after treatment; scar formation during the last 14 days Mortality: None Morphological findings: None Test method: as described in 16 CFR 1500.40 LD50: > 2 000 mg/kg Result: the notified chemical was of low acute dermal toxicity in rabbits and may be a severe skin irritant No. 2 (Heenehan et al., 1977a) Species/strain: rabbit/New Zealand White Number/sex of animals: 1/sex/dose group Observation period: 14 days Method of administration: occlusive dressing for 24 hours; test substance as an aqueous slurry at 200 mg/kg, 500 mg/kg and 2 000 mg/kg on abraded and non abraded skin Clinical observations: slight erythema was observed in one animal (500 mg/kg) and severe erythema was observed in the remaining five animals following dressing removal; slight oedema was observed in one animal (500 mg/kg), moderate oedema was observed in 4 animals and severe oedema in one animal (2 000 mg/kg); lethargy was noted in one animal during the first 24 hours following compound
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