Table e-1 Rehabilitation and Exercise Studies in MS – Intervention target Intervention Outcome Study Design Balance Aerobic training1 Improving symptoms Randomized, and QoL controlled study Balance Balance rehabilitation Reduced fall rate and Randomized, for motor and sensory improved balance controlled trial strategies2 Balance Balance exercise Reduced falls and Multicenter, program3 improved balance single-group, pretest-posttest trial Balance, cognition, Exercise Training4 Exercise can yield Literature review and fatigue, depression, improvements in meta-analyses walking, QoL walking, balance, cognition, fatigue, depression, QoL Fatigue and balance Vestibular Clinically relevant Randomized, rehabilitation5 changes in fatigue controlled trial and balance Fatigue and mobility Treadmill training6 Walking speed and Prospective, endurance increased. randomized, No significant change controlled trial in fatigue. Fatigue Fatigue management Novel, Randomized, plus physical activity multidisciplinary controlled trial intervention7 effort to combine fatigue management and physical activity promotion Fatigue Endurance exercise8 Maximal walking Randomized, distance improved. controlled trial Fatigue Aerobic training9 Maximum exercise Randomized, tolerance and walking crossover controlled capacity improved. study Intervention target Intervention Outcome Design Fatigue, mood Aerobic training10 Improved upper- and Randomized, lower-extremity controlled strength, reduced depression and anger scores, improved fitness and QoL. Fatigue, function and Multidisciplinary Rehabilitation Systematic review participation rehabilitation and improves function and participation
Table e-1 – Rehabilitation and Exercise Studies in MS Intervention target Intervention Outcome Study Design Balance Aerobic training1 Improving symptoms and QoL Randomized, controlled study Balance Balance rehabilitation for motor and sensory strategies2 Reduced fall rate and improved balance Randomized, controlled trial Balance Balance exercise program3 Reduced falls and improved balance Multicenter, single-group, pretest-posttest trial Balance, cognition, fatigue, depression, walking, QoL Exercise Training4 Exercise can yield improvements in walking, balance, cognition, fatigue, depression, QoL Literature review and meta-analyses Fatigue and balance Vestibular rehabilitation5 Clinically relevant changes in fatigue and balance Randomized, controlled trial Fatigue and mobility Treadmill training6 Walking speed and endurance increased. No significant change in fatigue. Prospective, randomized, controlled trial Fatigue Fatigue management plus physical activity intervention7 Novel, multidisciplinary effort to combine fatigue management and physical activity promotion Randomized, controlled trial Fatigue Endurance exercise8 Maximal walking distance improved. Randomized, controlled trial Fatigue Aerobic training9 Maximum exercise tolerance and walking capacity improved. Randomized, crossover controlled study Intervention target Intervention Outcome Design Fatigue, mood Aerobic training10 Improved upper- and lower-extremity strength, reduced depression and anger scores, improved fitness and QoL. Randomized, controlled Fatigue, function and participation Multidisciplinary rehabilitation and Rehabilitation improves function and participation Systematic review
16170_Table_e-1.docx