Oral 14 days Rat- Fischer 344 > 4% dose- decreased body Hejtmancik (drinking weight (severe dehydration); et al., water) 2% dose (females)- increased 1985a@ kidney weight Oral 14 days B6C3F1 8% dose- decreased body Hejtmancik (drinking weight, dehydration, histologic et al., water) changes in liver; > 4% dose- decreased thymus weight; NOEL = 9 000-10 000 mg/kg/day Oral (diet) 28 days Rat > 80 mg/kg/day- mortality, Smyth et al., decreased growth rate, 1951@ organ histopathology Oral (feed) < 168 days Rat Kidney and histopathology Kindsvatter, 1940@ Oral < 168 days Guinea pig Kidney and histopathology Kindsvatter, (gavage) 1940@ Dermal 14 days Rat- Fischer 344 2 250 mg/kg/d- decreased body Hejtmancik weight; et al., > 563 mg/kg/d- skin irritation Melnick et al., 1988@ Dermal 14 days B6C3F1 All skin irritation (males); Hejtmancik > 427 mg/kg/d- skin irritation et al., (females); 1985d@; NOAEL = 281 mg/kg/day(rat), 1 Melnick et 686 mg/kg/day (mouse) al., 1988@ Dermal 91 days Rat- Fischer 344 2 000 mg/kg/d- decreased body Hejtmancik weight, blood and urinary et al., effects, pituitary gland 1987e@; hypertrophy; NTP > 250 mg/kg/d- skin irritation (1994)@ (males); > 500 mg/kg/d- increased kidney weight > 1 000 mg/kg/d- increased kidney weight and pathology (females); > 500 mg/kg/d- skin irritation (females) Dermal 91 days B6C3F1 4 000 mg/kg/d- skin irritation, Hejtmancik increased liver and kidney et al., weight*; increased spleen weight 1987f@; (females); NTP All decreased body (1994)@ weight* (males) Dermal 91 days Mouse- Skin irritation DePass et al., C3H/HeJ 1995@
Oral (drinking water) 14 days Rat- Fischer 344 > 4% dose- decreased body weight (severe dehydration); 2% dose (females)- increased kidney weight Hejtmancik et al., 1985a@ Oral (drinking water) 14 days B6C3F1 8% dose- decreased body weight, dehydration, histologic changes in liver; > 4% dose- decreased thymus weight; NOEL = 9 000-10 000 mg/kg/day Hejtmancik et al., Oral (diet) 28 days Rat > 80 mg/kg/day- mortality, decreased growth rate, histopathology Smyth et al., 1951@ Oral (feed) < 168 days Rat Kidney and histopathology Kindsvatter, 1940@ Oral (gavage) < 168 days Guinea pig Kidney and histopathology Kindsvatter, 1940@ Dermal 14 days Rat- Fischer 344 2 250 mg/kg/d- decreased body weight; > 563 mg/kg/d- skin irritation Hejtmancik et al., Melnick et al., 1988@ Dermal 14 days B6C3F1 All skin irritation (males); > 427 mg/kg/d- skin irritation (females); NOAEL = 281 mg/kg/day(rat), 1 686 mg/kg/day (mouse) Hejtmancik et al., 1985d@; Melnick et al., 1988@ Dermal 91 days Rat- Fischer 344 2 000 mg/kg/d- decreased body weight, blood and urinary effects, pituitary gland hypertrophy; > 250 mg/kg/d- skin irritation (males); > 500 mg/kg/d- increased kidney weight > 1 000 mg/kg/d- increased kidney weight and pathology (females); > 500 mg/kg/d- skin irritation (females) Hejtmancik et al., 1987e@; NTP (1994)@ Dermal 91 days B6C3F1 4 000 mg/kg/d- skin irritation, increased liver and kidney weight*; increased spleen weight (females); All decreased body weight* (males) Hejtmancik et al., 1987f@; NTP (1994)@ Dermal 91 days Mouse- C3H/HeJ Skin irritation DePass et al., 1995@ organ
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