none Morphological findings: OECD guideline TG 403 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) > 5.32 mg/L LC50: the notified chemical was of very low acute Result: inhalation toxicity in rats 9.1.4 Skin Irritation (Liggett, rabbit/New Zealand Species/strain: 3/females Number/sex of animals: 12 days Observation period: 0.5 mL of the notified chemical applied a Method of administration: 625 mm2 gauze pad under occlusive dressing for 4 hours Draize scores:(Draize, 1959) of unirrigated eyes Time after treatment (days) Animal # * 1 2 3 4 5 6 7 8 9 Erythema 1 1 1 2 2 2 2 2 1a 0a 0a 2 1 1 2 2 2 2 2a 1a 0a 0a 3 1 1 2 2 2 2 2a 1a 1a 0a Oedema 1 1 1 1 1 1 1 1 1 0 0 2 1 1 2 2 2 2 1 1 0 0 3 1 1 2 2 2 2 1 1 1 0 see Attachment 1 for Draize scales a=sloughing of epidermis *=approximately 30 minutes after removal of the dressing Directive 84/449/EEC (OJ No. L251) Part B Test method: Method B.4 (European Economic Community, 1984) very slight erythema was observed in all three Result: animals 30 minutes after removal of the dressing; well-defined erythema was seen in all three animals from day 2 to 6 and continued as very slight erythema up to day 7 and in one animal up to day
Morphological findings: Test method: none OECD guideline TG 403 (Organisation for Economic Co-operation and Development, 1995- 1996) LC50: > 5.32 mg/L Result: the notified chemical was of very low acute inhalation toxicity in rats 9.1.4 Skin Irritation (Liggett, Species/strain: rabbit/New Zealand Number/sex of animals: 3/females Observation period: 12 days Method of administration: 0.5 mL of the notified chemical applied a 625 mm2 gauze pad under occlusive dressing for 4 hours Draize scores:(Draize, 1959) of unirrigated eyes Time after treatment (days) Animal # Erythema * 1 2 3 4 5 6 7 8 9 1 1 1 2 2 2 2 2 1a 0a 0a 2 1 1 2 2 2 2 2a 1a 0a 0a 3 1 1 2 2 2 2 2a 1a 1a 0a Oedema 1 1 1 1 1 1 1 1 1 0 0 2 1 1 2 2 2 2 1 1 0 0 3 1 1 2 2 2 2 1 1 1 0 see Attachment 1 for Draize scales a=sloughing of epidermis *=approximately 30 minutes after removal of the dressing Test method: Directive 84/449/EEC (OJ No. L251) Part B Method B.4 (European Economic Community, 1984) Result: very slight erythema was observed in all three animals 30 minutes after removal of the dressing; well-defined erythema was seen in all three animals from day 2 to 6 and continued as very slight erythema up to day 7 and in one animal up to day
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