Butorphanol (Stadol) Nalbuphine (Nubain) Buprenorphine (Buprenex) receptor Bind to MU receptors and act as a partial Agonist OR Antagonist effects Provide weaker analgesia than opioid agonists good for mild moderate pain – – Produce analgesia without respiratory depression side Antagonist quality creates a effect for analgesia (only first dose effective) “CEILING” Low potential for physical dependence effects Side effects similar to Opioids May cause Dysphoric Reactions Opioid Agonists-Antagonists Pentazocine Butorphanol Nalbuphine Buprenorphine (Talwin) (Stadol) (Nubain ) (Buprenex) moa Opioid agonist Similar to Related to Derived from Opioid Alkaloid: Weak antagonist Pentazocine Oxymorphone Thebaine Naloxone
Butorphanol (Stadol) Nalbuphine (Nubain) Buprenorphine (Buprenex) receptor Bind to MU receptors and act as a partial Agonist OR Antagonist effects Provide weaker analgesia than opioid agonists – good for mild – moderate pain Produce analgesia without respiratory depression side effects Antagonist quality creates a “CEILING” effect for analgesia (only first dose effective) Low potential for physical dependence Side effects similar to Opioids May cause Dysphoric Reactions Opioid Agonists-Antagonists Pentazocine (Talwin) Butorphanol (Stadol) Nalbuphine (Nubain ) Buprenorphine (Buprenex) moa Opioid agonist Weak antagonist Similar to Pentazocine Related to Oxymorphone Naloxone Derived from Opioid Alkaloid: Thebaine
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