> 5000 mg/kg LD50: OLOA 777R was of very low acute oral toxicity in rats Result: 9.1.2 Dermal Toxicity (Driscoll, 1998b) rat/Sprague-Dawley CD Species/strain: 5/sex Number/sex of animals: 14 days Observation period: single, 24-hour semi-occluded application to intact skin; Method of administration: dose level 2000 mg/kg bodyweight OECD TG 402; EC directive 92/69/EEC Test method: no deaths occurred during the study Mortality: no clinical of toxicity were noted during the study; all Clinical observations: animals showed expected gain in bodyweight during the study no abnormalities were noted at necropsy Morphological findings: no signs of skin irritation were noted during the study Dermal observations: > 2000 mg/kg bodyweight LD50: OLOA 777R was of low dermal toxicity in rats Result: 9.1.3 Inhalation Toxicity No inhalation toxicity data were presented by the notifier, with the argument that because the notified polymer has a very low vapour pressure (less than 4.910-5 kPa at 25°C) and a viscosity of 520 cSt at 100°C, it is unlikely to present an inhalation hazard either as a vapour or as an aerosol. This argument was accepted for the purposes of this assessment. Skin Irritation (Driscoll, 1998a) rabbit/New Zealand white Species/strain: 6/male Number/sex of animals: 4 days Observation period:
LD50: > 5000 mg/kg Result: OLOA 777R was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (Driscoll, 1998b) Species/strain: rat/Sprague-Dawley CD Number/sex of animals: 5/sex Observation period: 14 days Method of administration: single, 24-hour semi-occluded application to intact skin; dose level 2000 mg/kg bodyweight Test method: OECD TG 402; EC directive 92/69/EEC Mortality: no deaths occurred during the study Clinical observations: no clinical of toxicity were noted during the study; all animals showed expected gain in bodyweight during the study Morphological findings: no abnormalities were noted at necropsy Dermal observations: no signs of skin irritation were noted during the study LD50: > 2000 mg/kg bodyweight Result: OLOA 777R was of low dermal toxicity in rats 9.1.3 Inhalation Toxicity No inhalation toxicity data were presented by the notifier, with the argument that because the notified polymer has a very low vapour pressure (less than 4.910-5 kPa at 25°C) and a viscosity of 520 cSt at 100°C, it is unlikely to present an inhalation hazard either as a vapour or as an aerosol. This argument was accepted for the purposes of this assessment. Skin Irritation (Driscoll, 1998a) Species/strain: rabbit/New Zealand white Number/sex of animals: 6/male Observation period: 4 days
NA731FR.docx