Summary of Acute Toxicity Test Species Outcome Reference Acute oral toxicity Rat LD50> 2 000 mg/kg (Henkel KGaA, C16-C18 Esterquat 1994b) Skin irritation Primary Skin Irritation Rabbit Slight to moderate (Scantox, 1999) irritant Notified Chemical Open Epidermal Test Non irritating (Henkel KGaA, 1994f) C16-C18 Esterquat (Henkel KGaA, Eye irritation Rabbit Slight to moderate 1993) Stepantex VS 90 irritant Skin sensitisation: Buehler Method Guineapig Non sensitising (Henkel KGaA, Stepantex VS 90 1991b) Maximisation Test Guineapig Inconclusive (Henkel KGaA, Stepantex VS 90 1991c) (Pharmaco UK Repeated Insult Patch Human Non sensitising Ltd, 1995) Test Dehyquart F75 9.1.1 Oral Toxicity (Henkel KGaA, Esterquat C16-C18 Test substance: Rat/Hsd/Win:WU Species/strain: 5/sex Number/sex of animals: 14 days Observation period: 2 000 mg/kg by gavage, dose volume of 20 mL/kg bw Method of administration: OECD TG 401; EC Directive 91/325/EEC Test method: No symptoms observed Clinical observations: Nil Mortality: No treatment related findings. One animal had moderate Morphological findings: hydrometra in uterine horns
Summary of Acute Toxicity Test Species Outcome Reference Acute oral toxicity C16-C18 Esterquat Rat LD50> 2 000 mg/kg (Henkel KGaA, 1994b) Skin irritation Primary Skin Irritation Notified Chemical Rabbit Slight to moderate irritant (Scantox, 1999) Open Epidermal Test C16-C18 Esterquat Non irritating (Henkel KGaA, 1994f) Eye irritation Stepantex VS 90 Rabbit Slight to moderate irritant (Henkel KGaA, 1993) Skin sensitisation: Buehler Method Stepantex VS 90 Guineapig Non sensitising (Henkel KGaA, 1991b) Maximisation Test Stepantex VS 90 Guineapig Inconclusive (Henkel KGaA, 1991c) Repeated Insult Patch Test Dehyquart F75 Human Non sensitising (Pharmaco UK Ltd, 1995) 9.1.1 Oral Toxicity (Henkel KGaA, Test substance: Esterquat C16-C18 Species/strain: Rat/Hsd/Win:WU Number/sex of animals: 5/sex Observation period: 14 days Method of administration: 2 000 mg/kg by gavage, dose volume of 20 mL/kg bw Test method: OECD TG 401; EC Directive 91/325/EEC Clinical observations: No symptoms observed Mortality: Nil Morphological findings: No treatment related findings. One animal had moderate hydrometra in uterine horns
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