at 0.13 and 1.1 mg/L (TMP) changes observed in (Rodford, 1996) circulatory system, inflammatory and degenerative organs chronic oral toxicity rat at 20% for up to (caprylic/capric 18 months no toxic triglyceride oils) effects (Rodford, 1996) no tumourigenic (caprylic/capric carcinogenicity rat response triglyceride oils) no tumourigenic (caprylic/capric mouse response triglyceride oils) (Rodford, 1996) significantly NMU rat lower total (caprylic/capric (mammary tumour mammary triglyceride model) tumours oils) (Rodford, 1996) Subacute Oral Toxicity (RB 105) Species/strain: 20/sex Number/sex of animals: gavage;vehicle arachis oil BP Method of administration: test substance administered daily for a total of 28 days: Dose/Study duration: control 0 mg/kg/day low dose 150 mg/kg/day mid dose 400 mg/kg/day high dose 1 000 mg/kg/day OECD TG 407 Test method: no clinical signs noted in any dose group Clinical observations: Clinical chemistry/ no treatment related effects were detected Haematology no treatment related effects Urinalysis: no treatment related changes Histopathology: no treatment related effects Organ Weights:
at 0.13 and 1.1 mg/L changes observed in circulatory system, inflammatory and degenerative organs (TMP) (Rodford, 1996) chronic oral toxicity rat at 20% for up to 18 months no toxic effects (caprylic/capric triglyceride oils) (Rodford, 1996) carcinogenicity rat mouse no tumourigenic response no tumourigenic response (caprylic/capric triglyceride oils) (caprylic/capric triglyceride oils) (Rodford, 1996) NMU rat (mammary tumour model) significantly lower total mammary tumours (caprylic/capric triglyceride oils) (Rodford, 1996) Subacute Oral Toxicity (RB 105) Species/strain: Number/sex of animals: 20/sex Method of administration: gavage;vehicle arachis oil BP Dose/Study duration: test substance administered daily for a total of 28 days: control 0 mg/kg/day low dose 150 mg/kg/day mid dose 400 mg/kg/day high dose 1 000 mg/kg/day Test method: OECD TG 407 Clinical observations: no clinical signs noted in any dose group Clinical chemistry/ Haematology no treatment related effects were detected Urinalysis: no treatment related effects Histopathology: no treatment related changes Organ Weights: no treatment related effects
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