Seizures Complex partial Complex partial Complex partial No information seizures with seizures, controlled with seizures, controlled with available generalization, Diazepam. Lamotrigine. Right controlled with posterior anomalies on Oxcarbazepine. EEG at age 9 Intermittent focal slowing of left frontal region Irritability Yes No information No information No information available available available Attention Deficit short attention span ADHD ADHD No information available Obsessive or Yes No information No information No information available Aggressive Behavior available available Autism Spectrum Yes No information No information No information available Disorder available available Age at brain Imaging MRI, at 5 MRI, at 16 MRI, at age 9 and 14 No information available Ventriculomegaly Normal ventricles Borderline No information No information available ventriculomegaly available Cortical Atrophy Mild diffuse cerebral No information No information No information available atrophy available available Prominent Virchow Yes Yes, at age 11 on CT No information No information available Spaces available Findings Structural Anomalies Left posterior No focal lesion No focal lesion No information arachnoid cyst Neuroimaging available Corpus Callosum Mildly thinned corpus No information No information No information available Abnormalities callosum available available Subclones of each cell line used in the experiments described in this Supplementary Table 3. manuscript and the number of independent differentiations of each cell clone for each protocol. Subclone NPC Neural Glutamatergic GABAergic Subject ID differentiation differentiation Wortmannin SC79 differentiation differentiation HS1-11 11 3 3 3 3 3 3 RMK0162D 1 3 3 3 3 3 3 3 3 3 3 3 3 3 RMK0165D 3 3 3 3 3 3 3 5 3 3 3 3 3 3 RMK0056C 1 3 3 3 3 3 3 12 3 3 3 3 3 3
Seizures Complex partial seizures with generalization, controlled with Oxcarbazepine. Intermittent focal slowing of left frontal region No information available Complex partial seizures, controlled with Diazepam. Complex partial seizures, controlled with Lamotrigine. Right posterior anomalies on EEG at age 9 Irritability No information available No information available Yes No information available Attention Deficit short attention span No information available ADHD ADHD Obsessive or Aggressive Behavior No information available No information available Yes No information available Autism Spectrum Disorder Yes No information available No information available No information available Neuroimaging Findings Age at brain Imaging MRI, at 5 No information available MRI, at 16 MRI, at age 9 and 14 Ventriculomegaly Normal ventricles No information available Borderline ventriculomegaly No information available Cortical Atrophy No information available No information available Mild diffuse cerebral atrophy No information available Prominent Virchow Spaces Yes No information available Yes, at age 11 on CT No information available Structural Anomalies Left posterior arachnoid cyst No information available No focal lesion No focal lesion Corpus Callosum Abnormalities Mildly thinned corpus callosum No information available No information available No information available Supplementary Table 3. Subclones of each cell line used in the experiments described in this manuscript and the number of independent differentiations of each cell clone for each protocol. Subject Subclone ID NPC differentiation Neural differentiation Wortmannin SC79 Glutamatergic differentiation GABAergic differentiation HS1-11 11 3 3 3 3 3 3 RMK0162D 1 3 3 3 3 3 3 3 3 3 3 3 3 3 RMK0165D 3 3 3 3 3 3 3 5 3 3 3 3 3 3 RMK0056C 1 3 3 3 3 3 3 12 3 3 3 3 3 3
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