Dermal Toxicity (McRae, 1995) rat/ Sprague Dawley Species/strain: 5/sex Number/sex of animals: 15 days Observation period: a single dose of 2 000 mg/kg (166.67% w/v in corn oil) Method of administration: applied to an intact skin site and covered with semi- occlusive dressing; after 24 hours the dressing and residual test material were removed bodyweight fluctuations in the occasional animal Clinical observations: OECD TG 402 Test method: none Mortality: none Morphological findings: > 2 000 mg/kg LD50: the notified chemical was of very low dermal toxicity in rats Result: Inhalation Toxicity An acute inhalation toxicity test has not been conducted for the notified chemical and claims were made and accepted for variation of schedule requirements for this toxicological end point. To support their claim the notifier states that the median particle size of the notified chemical is 40 in diameter, with less than 10% with a diameter of 10 This coupled m m. with the high specific gravity and negligible vapour pressure of the substance, limits exposure via the inhalation The notifier also states that acute dermal and oral studies indicate the notified chemical is unlikely to be harmful. Skin Irritation (Parcell, 1995) rabbit/New Zealand White Species/strain: 3 females Number/sex of animals: 4 days Observation period: 0.5 g of the test substance was applied to intact skin site; the Method of administration: site was covered with semi occlusive dressing; after 4 hours the dressing and residual test material were removed OECD TG 404 Test method:
Dermal Toxicity (McRae, 1995) Species/strain: rat/ Sprague Dawley Number/sex of animals: 5/sex Observation period: 15 days Method of administration: a single dose of 2 000 mg/kg (166.67% w/v in corn oil) applied to an intact skin site and covered with semi- occlusive dressing; after 24 hours the dressing and residual test material were removed Clinical observations: bodyweight fluctuations in the occasional animal Test method: OECD TG 402 Mortality: none Morphological findings: none LD50: > 2 000 mg/kg Result: the notified chemical was of very low dermal toxicity in rats Inhalation Toxicity An acute inhalation toxicity test has not been conducted for the notified chemical and claims were made and accepted for variation of schedule requirements for this toxicological end point. To support their claim the notifier states that the median particle size of the notified chemical is 40 m in diameter, with less than 10% with a diameter of 10 m. This coupled with the high specific gravity and negligible vapour pressure of the substance, limits exposure via the inhalation The notifier also states that acute dermal and oral studies indicate the notified chemical is unlikely to be harmful. Skin Irritation (Parcell, 1995) Species/strain: rabbit/New Zealand White Number/sex of animals: 3 females Observation period: 4 days Method of administration: 0.5 g of the test substance was applied to intact skin site; the site was covered with semi occlusive dressing; after 4 hours the dressing and residual test material were removed Test method: OECD TG 404
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