(Covance Laboratories Inc 1998b) OGA 600 Test 2 16 2 0 0 4 15 1 0 0 Undiluted (39% OGA 499) Naïve 4 5 1 0 0 2 7 1 0 0 No. of test animals with 2/20 1/20 positive response: 5% OGA 600 Test 20 0 0 0 0 18 2 0 0 0 in mineral oil (2% OGA 499) Naïve 10 0 0 0 0 10 0 0 0 0 0/20 0/20 Total No. of test animals with positive response: OGA 600 50% OGA 600 25% OGA 600 Test 6 14 0 0 0 7 13 0 0 0 Non- Diluted to 1% OGA 499 in mineral oil. w/v w/v Sensitising (Covance Laboratories Inc in mineral oil in mineral oil Naïve 1 9 0 0 0 1 9 0 0 0 (0.5% OGA (0.25% OGA 0/20 0/20 Total No. of test animals with positive response: 499) 499) 1 One animal was euthanised on Day 29. Necropsy did not reveal treatment related effects. –
(Covance Laboratories Inc 1998b) OGA 600 Undiluted (39% OGA 499) Test 2 16 2 0 0 4 15 1 0 0 Naïve 4 5 1 0 0 2 7 1 0 0 No. of test animals with positive response: 2/20 1/20 5% OGA 600 in mineral oil (2% OGA 499) Test 20 0 0 0 0 18 2 0 0 0 Naïve 10 0 0 0 0 10 0 0 0 0 Total No. of test animals with positive response: 0/20 0/20 OGA 600 Diluted to 1% OGA 499 in mineral oil. (Covance Laboratories Inc 50% OGA 600 w/v in mineral oil (0.5% OGA 499) 25% OGA 600 w/v in mineral oil (0.25% OGA 499) Test 6 14 0 0 0 7 13 0 0 0 Non- Sensitising Naïve 1 9 0 0 0 1 9 0 0 0 Total No. of test animals with positive response: 0/20 0/20 1 – One animal was euthanised on Day 29. Necropsy did not reveal treatment related effects.
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