0, 200, 400 and 800 mg/kg body weight Doses: Gavage Method of administration: OECD TG 474 Test method: No significant increase in the incidence of micronucleated Comment: cells was observed at any dose level. The notified chemical was non clastogenic under the Result: conditions of the test. 9.3.8 Dominant Lethal Test (Rosival and Szokolayová, Rats, Wistar Species/strain: 20 females, 10 males Number and sex of animals: 16.6mg/kg body weight (to Doses: Orally by diet Method of administration: OECD TG 478 Test method: This is a poorly reported study with no information on Comment: control procedures. No mortality in female rats was reported prior to autopsy. Increases in post-implant (0.7%) and total dominant lethality (1.9%) of foetuses were reported compared to controls but these were not deemed statistically significant. The notified chemical appears non mutagenic under the Result: conditions of this test. 9.3.9 Teratogenicity (Rosival and Szokolayová, 1985f) Mice, ICR strain Species/strain: 4 groups, 20 females per group Number and sex of animals: 0, 100, 200, 300 (or 400) mg/kg/day, days 6-15 of Doses: pregnancy. Gavage Method of administration: OECD TG 414 Test method: This is a poorly reported study with contradictory Comment: information on doses. Additive and dislocated ossification
Doses: 0, 200, 400 and 800 mg/kg body weight Method of administration: Gavage Test method: OECD TG 474 Comment: No significant increase in the incidence of micronucleated cells was observed at any dose level. Result: The notified chemical was non clastogenic under the conditions of the test. 9.3.8 Dominant Lethal Test (Rosival and Szokolayová, Species/strain: Rats, Wistar Number and sex of animals: 20 females, 10 males Doses: 16.6mg/kg body weight (to Method of administration: Orally by diet Test method: OECD TG 478 Comment: This is a poorly reported study with no information on control procedures. No mortality in female rats was reported prior to autopsy. Increases in post-implant (0.7%) and total dominant lethality (1.9%) of foetuses were reported compared to controls but these were not deemed statistically significant. Result: The notified chemical appears non mutagenic under the conditions of this test. 9.3.9 Teratogenicity (Rosival and Szokolayová, 1985f) Species/strain: Mice, ICR strain Number and sex of animals: 4 groups, 20 females per group Doses: 0, 100, 200, 300 (or 400) mg/kg/day, days 6-15 of pregnancy. Method of administration: Gavage Test method: OECD TG 414 Comment: This is a poorly reported study with contradictory information on doses. Additive and dislocated ossification
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