STUDY DESIGN OPTIONAL MODIFIERS Reporting observation on a single patient? CASE REPORT Reporting observations on multiple patients, CASE SERIES with similar findings, or treated in a similar way, but without a comparison group? Comparing observations or results on similar COMPARATIVE CASE patients who have been treated in more than SERIES one way? Comparing a treated and untreated group? Comparing previous exposure(s) between a *CASE-CONTROL STUDY of patients with a given disease or outcome and a group without the given disease or outcome? Determining the prevalence of a symptom, CROSS-SECTIONAL Clinic-based, sign, or disease in a group of individuals or STUDY community-based, examining associations between factors at population-based one point in time? Reporting on a group of individuals with COHORT STUDY defined characteristics before developing a condition or undergoing a procedure, and then observing them over time for the appearance of a disease or surgical result or complication. Reporting the results of a clinical CLINICAL TRIAL Randomized, experiment, that you have registered with masked, clinicaltrials.gov or a similar database, in multicenter which defined groups of subjects receive different treatments, placebo, or no treatment? Evaluating a diagnostic test or comparing EVALUATION OF more than one diagnostic test? DIAGNOSTIC TEST OR TECHNOLOGY Developing a questionnaire or interviewing QUESTIONNAIRE instrument? DEVELOPMENT No human subjects studied (only tissue, EXPERIMENTAL STUDY biopsies, and animals)? Reporting the available data addressing a SYSTEMATIC REVIEW or specific clinical question? META-ANALYSIS Reporting on a phase 4 open-label study, a DATABASE STUDY registry or surveillance system, or an administrative database?
STUDY DESIGN OPTIONAL MODIFIERS Reporting observation on a single patient? CASE REPORT Reporting observations on multiple patients, with similar findings, or treated in a similar way, but without a comparison group? CASE SERIES Comparing observations or results on similar patients who have been treated in more than one way? Comparing a treated and untreated group? COMPARATIVE CASE SERIES Comparing previous exposure(s) between a of patients with a given disease or outcome and a group without the given disease or outcome? *CASE-CONTROL STUDY Determining the prevalence of a symptom, sign, or disease in a group of individuals or examining associations between factors at one point in time? CROSS-SECTIONAL STUDY Clinic-based, community-based, population-based Reporting on a group of individuals with defined characteristics before developing a condition or undergoing a procedure, and then observing them over time for the appearance of a disease or surgical result or complication. COHORT STUDY Reporting the results of a clinical experiment, that you have registered with clinicaltrials.gov or a similar database, in which defined groups of subjects receive different treatments, placebo, or no treatment? CLINICAL TRIAL Randomized, masked, multicenter Evaluating a diagnostic test or comparing more than one diagnostic test? EVALUATION OF DIAGNOSTIC TEST OR TECHNOLOGY Developing a questionnaire or interviewing instrument? QUESTIONNAIRE DEVELOPMENT No human subjects studied (only tissue, biopsies, and animals)? EXPERIMENTAL STUDY Reporting the available data addressing a specific clinical question? SYSTEMATIC REVIEW or META-ANALYSIS Reporting on a phase 4 open-label study, a registry or surveillance system, or an administrative database? DATABASE STUDY
OPHTHA_STUDY_DESIGN.docx