Non-Opioid Drug Products for Pain Management The list that follows below is intended for informational purposes only and not intended to be either complete or to be used as guidance for opioid substitution. Clinicians have reported favorable experience with many drug and non-drug interventions for pain and headache. Not all of these observations are equally well supported by the best available evidence, and not all conditions or patients respond equally well to the same dose of the same agent. Competencies in the safe and effective diagnosis and treatment of painful conditions are complex skill sets. Appropriate clinical expertise should be sought in the individualized decision making required for optimal pain assessment and treatment. Brand FDA-Labeled Therapeutic Class Generic Name Off-Label Pain Use Name(s) Pain Indication Analgesics and Antipyretics, Acetaminophen Tylenol® Headache, - Miscellaneous musculoskeletal pain Acetaminophen Ofirmev® Mild to - injection moderate pain, moderate to severe pain (adjunct) Acetaminophen/ Excedrin® Headache, - aspirin Back and musculoskeletal Body pain Acetaminophen/ Excedrin® Headache - aspirin/caffeine (various products) Angiotensin-Converting Enalapril Vasotec® - Migraine prophylaxis Enzyme Inhibitors (ACE-I) Lisinopril Prinivil®, - Migraine prophylaxis Zestril® Anticonvulsants Carbamazepine Carbatrol®, Trigeminal - Epitol®, Neuralgia Tegretol®, Tegretol XR® Divalproex sodium Depakote®, Migraine - Depakote prophylaxis ER® Gabapentin Gralise®, Postherpetic Diabetic peripheral Horizant®, neuralgia neuropathy, fibromyalgia, Neurontin® postoperative pain (preemptive), chemotherapy-induced peripheral neuropathy Lacosamide Vimpat® - Diabetic peripheral neuropathy Lamotrigine Lamictal®, - Migraine prophylaxis, Lamictal neuropathic pain, ODT®, trigeminal neuralgia Lamictal XR®
Non-Opioid Drug Products for Pain Management The list that follows below is intended for informational purposes only and not intended to be either complete or to be used as guidance for opioid substitution. Clinicians have reported favorable experience with many drug and non-drug interventions for pain and headache. Not all of these observations are equally well supported by the best available evidence, and not all conditions or patients respond equally well to the same dose of the same agent. Competencies in the safe and effective diagnosis and treatment of painful conditions are complex skill sets. Appropriate clinical expertise should be sought in the individualized decision making required for optimal pain assessment and treatment. Therapeutic Class Generic Name Brand Name(s) FDA-Labeled Pain Indication Off-Label Pain Use Analgesics and Antipyretics, Miscellaneous Acetaminophen Tylenol® Headache, musculoskeletal pain - Acetaminophen injection Ofirmev® Mild to moderate pain, moderate to severe pain (adjunct) - Acetaminophen/ aspirin Excedrin® Back and Body Headache, musculoskeletal pain - Acetaminophen/ aspirin/caffeine Excedrin® (various products) Headache - Angiotensin-Converting Enzyme Inhibitors (ACE-I) Enalapril Vasotec® - Migraine prophylaxis Lisinopril Prinivil®, Zestril® - Migraine prophylaxis Anticonvulsants Carbamazepine Carbatrol®, Epitol®, Tegretol®, Tegretol XR® Trigeminal Neuralgia - Divalproex sodium Depakote®, Depakote ER® Migraine prophylaxis - Gabapentin Gralise®, Horizant®, Neurontin® Postherpetic neuralgia Diabetic peripheral neuropathy, fibromyalgia, postoperative pain (preemptive), chemotherapy-induced peripheral neuropathy Lacosamide Vimpat® - Diabetic peripheral neuropathy Lamotrigine Lamictal®, Lamictal ODT®, Lamictal XR® - Migraine prophylaxis, neuropathic pain, trigeminal neuralgia
non-opioid-drug-list-and-letter-july2016.docx