Rabbit/NZ White C14 C16 Non irritating – Rabbit/NZ White C14 C18 Olefin/Paraffin Non irritating – Rabbit/NZ White C14 C18 Olefin Non irritating – Rabbit/NZ White C14 C18 Olefin/Paraffin Non irritating – Rabbit/NZ White C14 C26 Olefin Non irritating – Rabbit/NZ White C14 C26 Olefin/Paraffin Non irritating – Rabbit/NZ White C18 C24 Olefins Non irritating – Rabbit/NZ White C18 C26 Olefin/Paraffin Non irritating – Rabbit/NZ White C18 C30 Olefin/Alcohol Non irritating – 9.1.7 Skin sensitisation 9.1.7.1 Landsteiner technique Guineapig/albino C12 C16 Alpha Olefin Non sensiting – 9.1.7.2 Buehler technique Guineapig/Hartley C16/C18 Alpha Olefins, isomerised Non sensitising 9.1.7.3 Magnusson and Kligman Guineapig/Dunkin C20 - 24 Alkenes, branched and linear Non sensitising Hartley White 9.1.7.4 Other Alkenes 9.1.7.4.1 Buehler technique Guineapig/strain not Neodene 16 Olefin Non sensitising specified (1-hexadecene) Guineapig/strain not Neodene 18 Alpha Olefin Non sensitising 9.1.7.4.2 specified (1-octadecene) 9.1.7.5 Other Alkenes Neodene 18 Alpha Olefin Non sensitising Repeated Patch Insult (1-octadecene) Test 9.2 Repeat Dose Toxicity 9.2.1 2-week, dermal Rat/Fischer 344 Gulftene 12-16 NOAEL = 1 000 mg/kg 9.2.2 Other Alkenes 4-week, dermal Rabbit/NZ C16 - C18 Slight hyperemia, exfoliation, oedema
Rabbit/NZ White C14 – C16 Non irritating Rabbit/NZ White C14 – C18 Olefin/Paraffin Non irritating Rabbit/NZ White C14 – C18 Olefin Non irritating Rabbit/NZ White C14 – C18 Olefin/Paraffin Non irritating Rabbit/NZ White C14 – C26 Olefin Non irritating Rabbit/NZ White C14 – C26 Olefin/Paraffin Non irritating Rabbit/NZ White C18 – C24 Olefins Non irritating Rabbit/NZ White C18 – C26 Olefin/Paraffin Non irritating Rabbit/NZ White C18 – C30 Olefin/Alcohol Non irritating 9.1.7 Skin sensitisation 9.1.7.1 Landsteiner technique Guineapig/albino C12 – C16 Alpha Olefin Non sensiting 9.1.7.2 Buehler technique Guineapig/Hartley C16/C18 Alpha Olefins, isomerised Non sensitising 9.1.7.3 Magnusson and Kligman Guineapig/Dunkin Hartley White C20 - 24 Alkenes, branched and linear Non sensitising 9.1.7.4 Other Alkenes 9.1.7.4.1 Buehler technique Guineapig/strain not specified Neodene 16 Olefin (1-hexadecene) Non sensitising 9.1.7.4.2 Guineapig/strain not specified Neodene 18 Alpha Olefin (1-octadecene) Non sensitising 9.1.7.5 Other Alkenes Repeated Patch Insult Test Neodene 18 Alpha Olefin (1-octadecene) Non sensitising 9.2 Repeat Dose Toxicity 9.2.1 2-week, dermal Rat/Fischer 344 Gulftene 12-16 NOAEL = 1 000 mg/kg 9.2.2 Other Alkenes 4-week, dermal Rabbit/NZ C16 - C18 Slight hyperemia, exfoliation, oedema
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