High:200 orthostatic hypotension, interaction with antiarrhythmics (may lead to mg/day po lowered seizure increased effect of either drug); may reduce threshold; sexual antihypertensive effect of clonidine; may dysfunction. augment hypotensive effect of thiazides. Psychiatric Disorders: Depression; Sidney H. Kennedy, MD, FRCPC, Sagar V. Parikh, MD, FRCPC and Sophie Grigoriadis, MD, PhD, FRCPC; Date of revision: March 2015 Contraindications (CI), Adverse Effects Medication Uses drug interactions (DI) Initial dose; typical dose Monitoring (common and severe) or cautions amitriptyline depression CI: MAOI therapy, MI, stroke, seizure, Adults: 50-100mg at monitor acute MI recovery paralytic ileus, urinary nights Children >12yrs lithium phase, use with retention, constipation, 20mg at nights levels cisapride blurred vision, every 2 hyperpyrexia, rash, months DI: sedatives, SSRIs, bone marrow cimetidine, thyroid depression, testicular meds Increases swelling, suicidal ideation in gynecomastia, children and alopecia, edema adolescents Dose modify in elderly
High:200 mg/day po orthostatic hypotension, lowered seizure threshold; sexual dysfunction. interaction with antiarrhythmics (may lead to increased effect of either drug); may reduce antihypertensive effect of clonidine; may augment hypotensive effect of thiazides. Psychiatric Disorders: Depression; Sidney H. Kennedy, MD, FRCPC, Sagar V. Parikh, MD, FRCPC and Sophie Grigoriadis, MD, PhD, FRCPC; Date of revision: March 2015 Medication Uses Contraindications (CI), drug interactions (DI) or cautions Adverse Effects (common and severe) Initial dose; typical dose Monitoring amitriptyline depression CI: MAOI therapy, acute MI recovery phase, use with cisapride DI: sedatives, SSRIs, cimetidine, thyroid meds Increases suicidal ideation in children and adolescents Dose modify in elderly MI, stroke, seizure, paralytic ileus, urinary retention, constipation, blurred vision, hyperpyrexia, rash, bone marrow depression, testicular swelling, gynecomastia, alopecia, edema Adults: 50-100mg at nights Children >12yrs 20mg at nights monitor lithium levels every 2 months
Nortriptyline_C.docx