3 days Observation period: A single, topical application of 0.5g to clipped skin for 4 Method of administration: using semi-occlusive dressing OECD TG 404 Test method: no skin irritation was caused by 4 hours exposure to the Comment: notified chemical all Draize scores were zero; – no symptoms of systematic toxicity were observed; purple staining of the treated skin was observed the notified chemical was not irritating to the skin of rabbits Result: Eye Irritation (NOTOX B.V,1996p) Rabbit/New Zealand White Species/strain: 3/male Number/sex of animals: 7 days Observation period: A single ocular dose of approximately 28mg (in 0.1mL) to Method of administration: one eye OECD TG 405 Test method:
Observation period: 3 days Method of administration: A single, topical application of 0.5g to clipped skin for 4 using semi-occlusive dressing Test method: OECD TG 404 Comment: no skin irritation was caused by 4 hours exposure to the notified chemical – all Draize scores were zero; no symptoms of systematic toxicity were observed; purple staining of the treated skin was observed Result: the notified chemical was not irritating to the skin of rabbits Eye Irritation (NOTOX B.V,1996p) Species/strain: Rabbit/New Zealand White Number/sex of animals: 3/male Observation period: 7 days Method of administration: A single ocular dose of approximately 28mg (in 0.1mL) to one eye Test method: OECD TG 405
NA679FR.docx