intrauterine growth retardation and prematurity, intrauterine growth retardation oligohydramnios. NH differs from most other and oligohydramnios. NH differs from most causes of neonatal liver disease, other than other causes of neonatal liver disease, other congenital infections, in that the condition begins than congenital infections, in that the condition in utero and fulminant liver disease is manifested begins in utero and fulminant liver disease is in the first few days of life. The aetiology and manifested in the first few days of life. The pathogenesis remains uncertain. The NH aetiology and pathogenesis remains uncertain. phenotype may be the outcome of numerous The NH phenotype may be the outcome of disease processes. There is also evidence, numerous disease processes. There is also however, that NH is an alloimmune disorder. evidence, however, that NH is an alloimmune First, there is an approximate 80% likelihood of disorder. First, there is an approximate 80% NH once a woman has an affected baby. Second, likelihood of NH once a woman has an affected mothers can have affected babies with different baby. Second, mothers can have affected babies fathers. It has not been described that fathers can with different fathers. It has not been described have affected half-siblings with different mothers. that fathers can have affected half-siblings with different mothers. Symptoms and signs Symptoms and signs Affected neonates present with signs of liver failure, including extreme cholestasis, Affected neonates present with signs of liver hypoalbuminaemia, coagulopathy, ascites and failure, including extreme cholestasis, hypoglycaemia. hypoalbuminaemia, coagulopathy, ascites and hypoglycaemia. Diagnosis of neonatal haemochromatosis is made after other causes of neonatal liver failure have been ruled out.
intrauterine growth retardation and oligohydramnios. NH differs from most other causes of neonatal liver disease, other than congenital infections, in that the condition begins in utero and fulminant liver disease is manifested in the first few days of life. The aetiology and pathogenesis remains uncertain. The NH phenotype may be the outcome of numerous disease processes. There is also evidence, however, that NH is an alloimmune disorder. First, there is an approximate 80% likelihood of NH once a woman has an affected baby. Second, mothers can have affected babies with different fathers. It has not been described that fathers can have affected half-siblings with different mothers. Symptoms and signs Affected neonates present with signs of liver failure, including extreme cholestasis, hypoalbuminaemia, coagulopathy, ascites and hypoglycaemia. Diagnosis of neonatal haemochromatosis is made after other causes of neonatal liver failure have been ruled out. prematurity, intrauterine growth retardation and oligohydramnios. NH differs from most other causes of neonatal liver disease, other than congenital infections, in that the condition begins in utero and fulminant liver disease is manifested in the first few days of life. The aetiology and pathogenesis remains uncertain. The NH phenotype may be the outcome of numerous disease processes. There is also evidence, however, that NH is an alloimmune disorder. First, there is an approximate 80% likelihood of NH once a woman has an affected baby. Second, mothers can have affected babies with different fathers. It has not been described that fathers can have affected half-siblings with different mothers. Symptoms and signs Affected neonates present with signs of liver failure, including extreme cholestasis, hypoalbuminaemia, coagulopathy, ascites and hypoglycaemia.
neonatal-haemochromatosis%28nh%29_0.DOCX