for Test 2 and Test 3, the observation times did not Comment: extend beyond 72 and 48 hours, respectively, even though dermal responses were still present at these times, therefore, the reversibility of the dermal effects cannot be evaluated Test 1: at 5%, the notified chemical was a slight irritant Result: to rabbit skin; Test 2: at 76%, the notified chemical was slight to moderate irritant to rabbit skin; Test 3: at 90%, the notified chemical was a moderate to severe irritant to rabbit skin; Eye Irritation 1, 2 and 3 were conducted by (Thompson GW 1981), (Harris DL 1975), and (Thompson GW 1981), respectively. Test 1: Varisoft 3690, 5 % solids Test Substance Test 2: Varisoft 3690, 76 % solids Test 3: Varisoft 3690, 90 % solids rabbit/New Zealand Species/strain: 3/sex/test Number/sex of animals: 7 days Observation period: 0.1 mL of the test substance placed on the everted Method of administration: lid of one eye; the contralateral eye served as the control Test 1: 24, 48, 72 and 96 hours and 7 days Observation after Test 2: 24, 48 and 72 hours application: Test 3: 24, 48, 72 and 96 hours and 7 days Draize scoresa of non-irrigated eyes: Test 1: VARISOFT 3690, 5% solids Time after Instillation Animal 1 day 2 days 3 days 4 days 7 days Cornea o a o a o a o a o a 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0
Comment: for Test 2 and Test 3, the observation times did not extend beyond 72 and 48 hours, respectively, even though dermal responses were still present at these times, therefore, the reversibility of the dermal effects cannot be evaluated Result: Test 1: at 5%, the notified chemical was a slight irritant to rabbit skin; Test 2: at 76%, the notified chemical was slight to moderate irritant to rabbit skin; Test 3: at 90%, the notified chemical was a moderate to severe irritant to rabbit skin; Eye Irritation 1, 2 and 3 were conducted by (Thompson GW 1981), (Harris DL 1975), and (Thompson GW 1981), respectively. Test Substance Test 1: Varisoft 3690, 5 % solids Test 2: Varisoft 3690, 76 % solids Test 3: Varisoft 3690, 90 % solids Species/strain: rabbit/New Zealand Number/sex of animals: 3/sex/test Observation period: 7 days Method of administration: 0.1 mL of the test substance placed on the everted lid of one eye; the contralateral eye served as the control Observation after application: Test 1: 24, 48, 72 and 96 hours and 7 days Test 2: 24, 48 and 72 hours Test 3: 24, 48, 72 and 96 hours and 7 days Draize scoresa of non-irrigated eyes: Test 1: VARISOFT 3690, 5% solids Time after Instillation Animal 1 day 2 days 3 days 4 days 7 days Cornea o a o a o a o a o a 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0
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