BKA (14) or Syme (1) 146 Diabetes 186 amp Minor and major 1993-1998 Not reported 66 (mean age) Neuropathic toe Van Damme et amp: 14% al 200186 Neuropathic midfoot amp: 9% re-amputation toe amputation: 28% Neuro-ischaemic midfoot amp: 25% re-amputation 89 Diabetes 65/89 healed by Minor (first ray 16±7 months Not reported 66±9 17% ulcer Dalla Paola et first intention. The amputations) recurrence during al 2003145 remaining 24 follow-up. healed after 8% re-amputation dressings. (no major amputation). 670 Diabetes + non Limb salvage Minor only 47.3 months ESRD, transmetatarsal Not reported Not reported Mortality 16% at 1 Sheahan et al diabetes (all had 89.8% at 1 year amputation (initial year. 2005134 PVD) amputation), and subsequent revascularization were factors related to limb loss. 165 Diabetes + non 208 forefoot Minor only 2 Renal insufficiency Not reported 25% Berceli et al diabetes amputations. 2006136 Closed amputation; 86% healed Staged amputation; 91% healed Open amputation; 70% healed 126 Diabetes + non Not reported Minor only Not reported Not reported 75±12.9 (DM) Not reported Retrospective Uzzaman et al diabetes 2011195 80.5±14.8 5 year mortality 27% (non DM) 194 Diabetes 18% of Minor 1 year Depth of ulcer, PVD, 65.2±11.6 Not reported Analysis of subgroup van Battum et al EURODIALE infection, and male sex in the EURODIALE 2011166 cohort underwent predicted minor cohort. The rate of minor amputation. amputation. minor amputations
BKA (14) or Syme (1) Van Damme et al 200186 146 Diabetes 186 amp Minor and major 1993-1998 Not reported 66 (mean age) Neuropathic toe amp: 14% Neuropathic midfoot amp: 9% re-amputation toe amputation: 28% Neuro-ischaemic midfoot amp: 25% re-amputation Dalla Paola et al 2003145 89 Diabetes 65/89 healed by first intention. The remaining 24 healed after dressings. Minor (first ray amputations) 16±7 months Not reported 66±9 17% ulcer recurrence during follow-up. 8% re-amputation (no major amputation). Sheahan et al 2005134 670 Diabetes + non diabetes (all had PVD) Limb salvage 89.8% at 1 year Minor only 47.3 months ESRD, transmetatarsal amputation (initial amputation), and subsequent revascularization were factors related to limb loss. Not reported Not reported Mortality 16% at 1 year. Berceli et al 2006136 165 Diabetes + non diabetes 208 forefoot amputations. Closed amputation; 86% healed Staged amputation; 91% healed Open amputation; 70% healed Minor only 2 Renal insufficiency Not reported 25% Uzzaman et al 2011195 126 Diabetes + non diabetes Not reported Minor only Not reported Not reported 75±12.9 (DM) 80.5±14.8 (non DM) Not reported Retrospective 5 year mortality 27% van Battum et al 2011166 194 Diabetes 18% of EURODIALE cohort underwent minor amputation. Minor 1 year Depth of ulcer, PVD, infection, and male sex predicted minor amputation. 65.2±11.6 Not reported Analysis of subgroup in the EURODIALE cohort. The rate of minor amputations
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