OECD TG 406 Test method: the notified chemical was a not a skin sensitiser in Result: guinea pigs Repeated Dose Toxicity (Lea & Spurgeon, 1994) rat/SD Species/strain: 5/sex/dose group Number/sex of animals: gavage in corn oil Method of administration: 0, 15, 150 or 1 000 mg/kg/day (control, low, mid or Dose/Study duration:: high respectively) for 28 days no deaths occurred during the study; non- Clinical observations: treatment-related and/or ocular discharge was observed in all groups; no treatment-related changes in body weight at week 4 or in body weight gain were observed during the study Clinical chemistry/Haematology no statistically significant differences between control and treatment Haematology: groups 7% increase in magnesium levels in high dose 10% Clinical chemistry: increase in aspartate transaminase, 68% increase in alanine transaminase, 32% increase in alkaline phosphatase levels in high dose males Macroscopic findings: no statistically significant differences in weights were observed; moderate fluid distension of the uterus was observed in 1 mid dose and 4 high dose females; enlargement of the mesenteric lymph nodes was observed in 1 high dose male
Test method: OECD TG 406 Result: the notified chemical was a not a skin sensitiser in guinea pigs Repeated Dose Toxicity (Lea & Spurgeon, 1994) Species/strain: rat/SD Number/sex of animals: 5/sex/dose group Method of administration: gavage in corn oil Dose/Study duration:: 0, 15, 150 or 1 000 mg/kg/day (control, low, mid or high respectively) for 28 days Clinical observations: no deaths occurred during the study; non- treatment-related and/or ocular discharge was observed in all groups; no treatment-related changes in body weight at week 4 or in body weight gain were observed during the study Clinical chemistry/Haematology Haematology: no statistically significant differences between control and treatment groups Clinical chemistry: 7% increase in magnesium levels in high dose 10% increase in aspartate transaminase, 68% increase in alanine transaminase, 32% increase in alkaline phosphatase levels in high dose males Macroscopic findings: no statistically significant differences in weights were observed; moderate fluid distension of the uterus was observed in 1 mid dose and 4 high dose females; enlargement of the mesenteric lymph nodes was observed in 1 high dose male
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