Dermal Toxicity (Arcelin, 1997) rat/HanIbm:WIST(SPF) Species/strain: 5/sex Number/sex of animals: 14 days Observation period: under semi-occlusive dressing for 24 Method of administration: hours no clinical signs or local effects on the Clinical observations: skin none Mortality: none Morphological findings: OECD guideline TG 402 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) > 2 000 mg/kg LD50: the notified chemical was of low acute Result: dermal toxicity in rats Inhalation Toxicity not available Skin Irritation (Parcell, 1995b) rabbit/New Zealand White Species/strain: 3/unspecified Number/sex of animals: 4 days Observation period: 0.5 mL of the notified chemical under semi- Method of administration: occlusive dressing for 4 hours
Dermal Toxicity (Arcelin, 1997) Species/strain: rat/HanIbm:WIST(SPF) Number/sex of animals: 5/sex Observation period: 14 days Method of administration: under semi-occlusive dressing for 24 hours Clinical observations: no clinical signs or local effects on the skin Mortality: none Morphological findings: none Test method: OECD guideline TG 402 (Organisation for Economic Co-operation and Development, 1995- 1996) LD50: > 2 000 mg/kg Result: the notified chemical was of low acute dermal toxicity in rats Inhalation Toxicity not available Skin Irritation (Parcell, 1995b) Species/strain: rabbit/New Zealand White Number/sex of animals: 3/unspecified Observation period: 4 days Method of administration: 0.5 mL of the notified chemical under semi- occlusive dressing for 4 hours
NA638FR.docx