16 CFR 1500.41 Test method: severe erythema was observed in all animals at 24 and Result: 72 hours post-treatment; slight oedema was observed in 3 animals at 24 hours and 5 animals at 72 hours with the remaining animals exhibiting moderate oedema the notified chemical was a severe skin irritant in rabbits (Gabriel, undated) Study No. 5 rabbit/Albino Species/strain: 6 Number/sex of animals: 72 Observation period: 0.5 g of the test substance was applied under an Method of administration: occluded gauze patch for 24 hours Federal Hazardous Substances Amendment (US Test method: Government, 1964) severe erythema was observed in all animals at 24 and Result: 72 hours post-treatment the notified chemical was a severe skin irritant in rabbits (Chang, 1981) Study No. 6 rabbit/New Zealand Species/strain: 6/test: 3 tests done Number/sex of animals: up to 48 Observation period: in all tests 0.5 g of the test substance was applied under Method of administration: a patch for 4 hours; the patches were: 25 cm2 gauze patch under occlusive plastic sheet; a Eye Occlusor” (6 in2); “Coverlet 25 cm2 gauze patch loosely wrapped in a plastic sheet Unspecified Test method: 1. at 4 hours, blanching and oedema in two rabbits, 4 Result:
Test method: 16 CFR 1500.41 Result: severe erythema was observed in all animals at 24 and 72 hours post-treatment; slight oedema was observed in 3 animals at 24 hours and 5 animals at 72 hours with the remaining animals exhibiting moderate oedema the notified chemical was a severe skin irritant in rabbits Study No. 5 (Gabriel, undated) Species/strain: rabbit/Albino Number/sex of animals: 6 Observation period: 72 Method of administration: 0.5 g of the test substance was applied under an occluded gauze patch for 24 hours Test method: Federal Hazardous Substances Amendment (US Government, 1964) Result: severe erythema was observed in all animals at 24 and 72 hours post-treatment the notified chemical was a severe skin irritant in rabbits Study No. 6 (Chang, 1981) Species/strain: rabbit/New Zealand Number/sex of animals: 6/test: 3 tests done Observation period: up to 48 Method of administration: in all tests 0.5 g of the test substance was applied under a patch for 4 hours; the patches were: 25 cm2 gauze patch under occlusive plastic sheet; a “Coverlet Eye Occlusor” (6 in2); 25 cm2 gauze patch loosely wrapped in a plastic sheet Test method: Unspecified Result: 1. at 4 hours, blanching and oedema in two rabbits, 4
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