10 males Number/sex of animals: 14 days Observation period: Whole body exposure to saturated mists for one hour; Method of administration: exposure concentration to aerosol size of <8m was 9 900 mg/m3; and 0.45m 2.0 m was 100 mg/m3. – US Federal Hazardous Substances Labelling Act. Test method: Animals were drowsy upon removal from the chamber. Clinical observations: Animals had very oily fur over. Nil. Mortality: No gross pathology at necropsy. Morphological findings: > 9 900 mg/m3 mist (1 hour) LD50: C12-C16 Alpha Olefin was of low acute inhalation toxicity Result: in rats. 9.1.3.2 Acute Inhalation Toxicity of C16 Alpha Olefin (Rinehart 1967) C16 alpha Olefin (98.5% olefins, 1.5% saturates) Test Substance: Rat/Wistar Species/strain: 10 Number/sex of animals: 14 days Observation period: Whole body exposure to saturated mists for one hour; exposure Method of administration: concentration to aerosol size of <8m was 8 500 mg/m3; and 0.45m 2.0 m was 150 mg/m3. – US Federal Hazardous Substances Labelling Act Test method: Animals were drowsy upon removal from the chamber. Clinical observations: Animals had very oily fur over. Nil. Mortality: No gross pathology at necropsy. Morphological findings: > 8 500 mg/m3 mist (1 hour) LD50: C16 Alpha Olefin was of low acute inhalation toxicity in rats. Result: 9.1.3.3 Acute Inhalation Toxicity of C16-C18 Alkene (EU 1995)
Number/sex of animals: 10 males Observation period: 14 days Method of administration: Whole body exposure to saturated mists for one hour; exposure concentration to aerosol size of <8m was 9 900 mg/m3; and 0.45m – 2.0 m was 100 mg/m3. Test method: US Federal Hazardous Substances Labelling Act. Clinical observations: Animals were drowsy upon removal from the chamber. Animals had very oily fur over. Mortality: Nil. Morphological findings: No gross pathology at necropsy. LD50: > 9 900 mg/m3 mist (1 hour) Result: C12-C16 Alpha Olefin was of low acute inhalation toxicity in rats. 9.1.3.2 Acute Inhalation Toxicity of C16 Alpha Olefin (Rinehart 1967) Test Substance: C16 alpha Olefin (98.5% olefins, 1.5% saturates) Species/strain: Rat/Wistar Number/sex of animals: 10 Observation period: 14 days Method of administration: Whole body exposure to saturated mists for one hour; exposure concentration to aerosol size of <8m was 8 500 mg/m3; and 0.45m – 2.0 m was 150 mg/m3. Test method: US Federal Hazardous Substances Labelling Act Clinical observations: Animals were drowsy upon removal from the chamber. Animals had very oily fur over. Mortality: Nil. Morphological findings: No gross pathology at necropsy. LD50: > 8 500 mg/m3 mist (1 hour) Result: C16 Alpha Olefin was of low acute inhalation toxicity in rats. 9.1.3.3 Acute Inhalation Toxicity of C16-C18 Alkene (EU 1995)
NA713FR.docx