observations were noted at the other doses as Clinical observations: follows: none at 100 mg/kg; clinical Dose 2 000 825 464 215 (mg/kg): Symptom Dyspnea 1-9D 1-6D 1H- 3-6D* Apathy 1-9D 1-6D 1D “ Staggering 2-9D 1H- “ Spastic Gait 2-9D 1D “ Faeces Blue- – 4H- 4H- 4H- “ Violet 7D 5D 1D Urine Blue- – 4H- Violet 4H- 6D 1-7D Piloerection 5D Diarrhea 4H- 8-16D 4H- Exsiccosis 6D 4D Poor General 4H- 7D State 5D 1-9D 1H- 3-6D 1-6D 6D 3-6D 1H- 1D H = hour, D = day Females Dose 2 000 825 464 215 (mg/kg): Symptom Dyspnea 3-7D* 1-16D 1-16D 4H- Apathy 3-7D 1-15D 1-8D 1D 3D 4H- Abnormal Posn 3-7D Staggering 2-15D 2-8D 1D Paresis 3D Spastic Gait 3-7D 2-15D 2-8D 4H- 1H- 1H- Faeces Blue- – Violet 7D 7D 7D Urine Blue- – Violet 4H- 4H- 4H- 4H- Piloerection 7D 7D 7D Diarrhea 4D Exsiccosis 8-21D 8-16D Impaired General 4H- 1-5H 1H- 1H- 5D 7D 5H 5D State 7D Poor General 3D 16D State 16D 1-15D 3-7D 1-8D 4H- 1D * H = hour, D = day
Clinical observations: none at 100 mg/kg; clinical observations were noted at the other doses as follows: Dose (mg/kg): 2 000 825 464 215 Symptom 3-6D* “ “ “ “ 4H- 6D 4H- 6D 4H- 5D 1-9D 1-9D 2-9D 2-9D 4H- 7D 1-7D 8-16D 7D 1-9D 1-6D 1-6D 4H- 5D 4H- 5D 1H- 1D 1H- 1D 4H- 1D 4H- 4D 1H- Dyspnea Apathy Staggering Spastic Gait Faeces – Blue- Violet Urine – Blue- Violet Piloerection Diarrhea Exsiccosis Poor General State 3-6D 1-6D 6D 3-6D 1H- 1D H = hour, D = day Females Dose (mg/kg): 2 000 825 464 215 Symptom Dyspnea Apathy Abnormal Posn Staggering Paresis Spastic Gait Faeces – Blue- Violet Urine – Blue- Violet Piloerection Diarrhea Exsiccosis Impaired General State Poor General State 3-7D* 3-7D 3D 3-7D 3D 3-7D 4H- 7D 4H- 7D 4H- 5D 3D 3-7D 1-16D 1-15D 2-15D 2-15D 1H- 7D 4H- 7D 8-21D 1-5H 7D 16D 1-15D 1-16D 1-8D 2-8D 2-8D 1H- 7D 4H- 7D 8-16D 1H- 5H 7D 16D 1-8D 4H- 1D 4H- 1D 4H- 4D 1H- 5D 4H- 1D * H = hour, D = day
NA538FR.docx