Hippocampal Subfield Volumes in Mood Disorders S1. Hippocampal subfield volume difference of bipolar I and II disorders vs. healthy subjects Abbreviations: BD-I, bipolar I disorder; BD-II, bipolar II disorder; HC, healthy controls; CA, cornu ammonis; GCL, granule cell layer; ML, molecular layer; Presub, presubiculum; Sub, subiculum and Tail, hippocampal tail. S2. Hippocampal subfield volume association with number of mood episodes in BD-I Abbreviations: BD-I, bipolar I disorder; CA, cornu ammonis; GCL, granule cell layer; ML, molecular layer; Presub, presubiculum; Sub, subiculum and Tail, hippocampal tail. Potential effect of lithium, anti-convulsants, psychosis history, anti-psychotics, and alcohol abuse We compared BD patients with vs. without lithium exposure and found that only left molecular layer (p=0.038) and left subiculum (p=0.004) had significantly larger volume in patients with lithium than those without lithium. However, neither would survive the multiple comparison correction. Although these results were preliminary, because we only had eight patients with lithium, all the regions showed higher volumes due to lithium, which was consistent to the literature. In line with these observations, most the main results got slightly more significant if we took the patients with lithium out from the analysis, e.g., left CA1, CA3,
Hippocampal Subfield Volumes in Mood Disorders S1. Hippocampal subfield volume difference of bipolar I and II disorders vs. healthy subjects Abbreviations: BD-I, bipolar I disorder; BD-II, bipolar II disorder; HC, healthy controls; CA, cornu ammonis; GCL, granule cell layer; ML, molecular layer; Presub, presubiculum; Sub, subiculum and Tail, hippocampal tail. S2. Hippocampal subfield volume association with number of mood episodes in BD-I Abbreviations: BD-I, bipolar I disorder; CA, cornu ammonis; GCL, granule cell layer; ML, molecular layer; Presub, presubiculum; Sub, subiculum and Tail, hippocampal tail. Potential effect of lithium, anti-convulsants, psychosis history, anti-psychotics, and alcohol abuse We compared BD patients with vs. without lithium exposure and found that only left molecular layer (p=0.038) and left subiculum (p=0.004) had significantly larger volume in patients with lithium than those without lithium. However, neither would survive the multiple comparison correction. Although these results were preliminary, because we only had eight patients with lithium, all the regions showed higher volumes due to lithium, which was consistent to the literature. In line with these observations, most the main results got slightly more significant if we took the patients with lithium out from the analysis, e.g., left CA1, CA3,
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