A dermal application (2 000 mg/kg in corn oil) under Method of administration: occlusive dressing for 24 hours. OECD TG 402 Test method: None Mortality: None Clinical observations: None Morphological findings: 3 female animals had either no bodyweight gain or low Comment: bodyweight gain. LD50: > 2 000 mg/kg The notified chemical was of low dermal toxicity in rats. Result: 9.1.3 Inhalation Toxicity Not provided. 9.1.4 Skin Irritation (Parcell, 1998b) Rabbit/New Zealand White Species/strain: 6 Number/sex of animals: 72 hours Observation period: A single application of the notified chemical (0.5 g) in corn Method of administration: oil under a semi-occlusive dressing for 4 hours. OECD TG 404 Test method: Draize scores for erythema and oedema were zero for all Draize scores: animals at 1, 24, 48 and 72 hours after dosing. The notified chemical was not irritating to the skin of Result: rabbits. 9.1.5 Eye Irritation (Parcell, 1998a) Rabbit/New Zealand Species/strain: 6 females Number/sex of animals:
Method of administration: A dermal application (2 000 mg/kg in corn oil) under occlusive dressing for 24 hours. Test method: OECD TG 402 Mortality: None Clinical observations: None Morphological findings: None Comment: 3 female animals had either no bodyweight gain or low bodyweight gain. LD50: > 2 000 mg/kg Result: The notified chemical was of low dermal toxicity in rats. 9.1.3 Inhalation Toxicity Not provided. 9.1.4 Skin Irritation (Parcell, 1998b) Species/strain: Rabbit/New Zealand White Number/sex of animals: 6 Observation period: 72 hours Method of administration: A single application of the notified chemical (0.5 g) in corn oil under a semi-occlusive dressing for 4 hours. Test method: OECD TG 404 Draize scores: Draize scores for erythema and oedema were zero for all animals at 1, 24, 48 and 72 hours after dosing. Result: The notified chemical was not irritating to the skin of rabbits. 9.1.5 Eye Irritation (Parcell, 1998a) Species/strain: Rabbit/New Zealand Number/sex of animals: 6 females
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