202/428 84 48 55 75 Beach, 2007 (13) Various agents‡ (47%) (67-93%) (26-72%) 126/252 79 51 HMW agents‡ 62 73 (50%) (68-88) (35-67) 424/1071 67 64 LMW agents‡ 56 75 (40%) (58-74) (56-71) At baseline of SIC 129/519 73 51 33 85 Malo, CEA 2011 (36) (various agents) (25%) At baseline of SIC 278/1012 80 47 36 86 Lemière, 2016 (37) (various agents) (28%) At baseline while still 131/430 exposed at work 95 40 41 95 (30%) (various agents) At baseline while off 147/582 67 52 32 82 work (various agents) (25%) At least one assessment during 157/479 98 39 44 98 work exposure (33%) (various agents) Legend: HMW: high molecular weight; LMW: low molecular weight; NSBH: nonspecific bronchial hyperresponsiveness; SIC: specific inhalation challenge. * OA defined by a positive specific inhalation challenge; 95% confidence interval within parentheses when available; † In the meta-analysis by Beach and coworkers, the time elapsed between the last work exposure and NSBH ‡ assessment was not available; the prevalence of OA and the predictive values of a single NSBH assessment were derived from the figures provided in reference (12). Table 4. Validity of immunological tests Positive Negative Predictive Predictive Prevalence Sensitivity Specificity Value Value Agent Test of OA* (%)† (%)† (%)† (%)† Reference HMW agents: 175/434 Beach, 2007 SPT‡ 81 (70-88) 60 (42-75) Various 73 81 (40%) (13) 113/246 sIgE‡ 73 (64-81) 79 (50-93) 86 82 (46%) Van Kampen, SPT Flour, wheat 37/71 (52%) 68 74 74 68 2008 (49) sIgE£ 37/71 (52%) 87 68 74 82 kUA/l ≥0.35 sIgE£ 37/71 (52%) 51 100 100 65 kUA/l ≥2.22
Various agents‡ 202/428 (47%) 84 (67-93%) 48 (26-72%) 55 75 Beach, 2007 (13) HMW agents‡ 126/252 (50%) 79 (68-88) 51 (35-67) 62 73 LMW agents‡ 424/1071 (40%) 67 (58-74) 64 (56-71) 56 75 At baseline of SIC (various agents) 129/519 (25%) 73 51 33 85 Malo, CEA 2011 (36) At baseline of SIC (various agents) 278/1012 (28%) 80 47 36 86 Lemière, 2016 (37) At baseline while still exposed at work (various agents) 131/430 (30%) 95 40 41 95 At baseline while off work (various agents) 147/582 (25%) 67 52 32 82 At least one assessment during work exposure (various agents) 157/479 (33%) 98 39 44 98 Legend: HMW: high molecular weight; LMW: low molecular weight; NSBH: nonspecific bronchial hyperresponsiveness; SIC: specific inhalation challenge. * OA defined by a positive specific inhalation challenge; † 95% confidence interval within parentheses when available; ‡ In the meta-analysis by Beach and coworkers, the time elapsed between the last work exposure and NSBH assessment was not available; the prevalence of OA and the predictive values of a single NSBH assessment were derived from the figures provided in reference (12). Table 4. Validity of immunological tests Agent Test Prevalence of OA* Sensitivity (%)† Specificity (%)† Positive Predictive Value (%)† Negative Predictive Value (%)† Reference HMW agents: Various SPT‡ 175/434 (40%) 81 (70-88) 60 (42-75) 73 81 Beach, 2007 (13) sIgE‡ 113/246 (46%) 73 (64-81) 79 (50-93) 86 82 Flour, wheat SPT 37/71 (52%) 68 74 74 68 Van Kampen, 2008 (49) sIgE£ ≥0.35 kUA/l 37/71 (52%) 87 68 74 82 sIgE£ ≥2.22 kUA/l 37/71 (52%) 51 100 100 65
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