Very slight to well defined erythema which persisted to the Comment: Day 7 observation. Very slight to defined oedema which cleared by the 48 hour observation. C16/C18 Alpha Olefins, Isomerised was slight to Result: moderately irritating to the skin of rabbits. 9.1.5.7 Acute Dermal Irritation of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) C20-24 Alkenes, branched and linear Test substance: Rabbit/New Zealand White Species/strain: 6 Number/sex of animals: 1, 24, 48, 72 and 96 post exposure Observation period: A single semi occluded application of 0.5 mL of the neat test Method of administration: substance to intact skin; after 4 hours residual test substance was removed by gentle swabbing with liquid paraffin; A contralateral area of untreated skin served as the control site. Control sites were similarly swabbed. OECD TG 404 Test method: No evidence of skin irritation was observed, all individual Dermal effects: scores were zero. Mean group score Erythema/eschar formation: 0.0 (24, 48 & 72 hour Oedema: 0.0 observation): C20-24 Alkenes, branched and linear was non irritating to Result: the skin of rabbits. 9.1.5.8 Acute Dermal Irritation of Other Alkenes (HEDSET 1-Octadecene) The following data, unless otherwise indicated, are from HEDSET data sheets for 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate these tests were not conducted in accordance with GLP or OECD or EC testing guidelines.
Comment: Very slight to well defined erythema which persisted to the Day 7 observation. Very slight to defined oedema which cleared by the 48 hour observation. Result: C16/C18 Alpha Olefins, Isomerised was slight to moderately irritating to the skin of rabbits. 9.1.5.7 Acute Dermal Irritation of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) Test substance: C20-24 Alkenes, branched and linear Species/strain: Rabbit/New Zealand White Number/sex of animals: 6 Observation period: 1, 24, 48, 72 and 96 post exposure Method of administration: A single semi occluded application of 0.5 mL of the neat test substance to intact skin; after 4 hours residual test substance was removed by gentle swabbing with liquid paraffin; A contralateral area of untreated skin served as the control site. Control sites were similarly swabbed. Test method: OECD TG 404 Dermal effects: No evidence of skin irritation was observed, all individual scores were zero. Mean group score (24, 48 & 72 hour observation): Erythema/eschar formation: 0.0 Oedema: 0.0 Result: C20-24 Alkenes, branched and linear was non irritating to the skin of rabbits. 9.1.5.8 Acute Dermal Irritation of Other Alkenes (HEDSET 1-Octadecene) The following data, unless otherwise indicated, are from HEDSET data sheets for 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate these tests were not conducted in accordance with GLP or OECD or EC testing guidelines.
NA844FR.docx