5/sex. Number/sex of animals: 15 days. Observation period: 5 000 mg/kg body weight by gavage Method of administration: EPA Health Effects Test Guidelines (August, 1982). Test method: No deaths were recorded over the observation period. Mortality: There were no signs of systemic toxicity. Clinical observations: No abnormalities were detected. Morphological findings: There were no adverse effects on bodyweight gain over the Comment: observation period. > 5 000 mg/kg. LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Food and Drug Research Laboratories Inc, 1985a) Rabbit/New Zealand White. Species/strain: 5/sex. Number/sex of animals: 15 days. Observation period: A single dose of 2 000 mg/kg of test substance was applied Method of administration: under occlusive conditions to the shorn dorsal skin of each animal for a period of 24 hours. EPA Health Effects Test Guidelines (August, 1982). Test method: No deaths were recorded over the observation period. Mortality: Anorexia, diarrheoa, nasal discharge or soft stools was Clinical observations: reported in some male and female rabbits. No abnormalities were detected. Morphological findings: There were no adverse effects on bodyweight gain over the Comment: observation period. > 2 000 mg/kg. LD50: The notified chemical was of low dermal toxicity in rats. Result:
Number/sex of animals: 5/sex. Observation period: 15 days. Method of administration: 5 000 mg/kg body weight by gavage Test method: EPA Health Effects Test Guidelines (August, 1982). Mortality: No deaths were recorded over the observation period. Clinical observations: There were no signs of systemic toxicity. Morphological findings: No abnormalities were detected. Comment: There were no adverse effects on bodyweight gain over the observation period. LD50: > 5 000 mg/kg. Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Food and Drug Research Laboratories Inc, 1985a) Species/strain: Rabbit/New Zealand White. Number/sex of animals: 5/sex. Observation period: 15 days. Method of administration: A single dose of 2 000 mg/kg of test substance was applied under occlusive conditions to the shorn dorsal skin of each animal for a period of 24 hours. Test method: EPA Health Effects Test Guidelines (August, 1982). Mortality: No deaths were recorded over the observation period. Clinical observations: Anorexia, diarrheoa, nasal discharge or soft stools was reported in some male and female rabbits. Morphological findings: No abnormalities were detected. Comment: There were no adverse effects on bodyweight gain over the observation period. LD50: > 2 000 mg/kg. Result: The notified chemical was of low dermal toxicity in rats.
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