Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Cedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) I Very slight oedema (barely perceptible) Well-defined erythema 2 Slight oedema (edges of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm 4 and extending beyond area of exposure) The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) Diffuse area, details of iris clearly I slight 25% to 50% 2 visible Easily visible translucent areas, details 2 mild 50% to 75% 3 of iris slightly obscure Opalescent areas, no details of iris 3 Greater than 75% 4 visible, size of pupil barely discernible moderate Opaque, iris invisible 4 severe CONJUNCTIVAF Redness Rating Cheniosis Rating Disc/i arge Rating Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely I Any swelling I slight Any amount different slight injected above normal slight from normal More diffuse, deeper 2 mod. Obvious swelling with mild Discharge ~vith mod. crimson red with partial eversion of lids moistening of lids and individual vessels not adjacent easily discernible Swelling with lids half- closed mod. Discharge with severe Diffuse beefy red 3 severe moistening of lids and Swelling with lids half- hairs and considerable closed to completely severe area around eve closed IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light I slight No reaction to haernorrhage, gross destruction 2 severe
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Cedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) Well-defined erythema I 2 Very slight oedema (barely perceptible) Slight oedema (edges of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm 4 and extending beyond area of exposure) The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity Diffuse area, details of iris clearly 0 none I slight 25% or less (not zero) 25% to 50% 2 visible Easily visible translucent areas, details 2 mild 50% to 75% 3 of iris slightly obscure Opalescent areas, no details of iris 3 Greater than 75% 4 visible, size of pupil barely discernible moderate Opaque, iris invisible 4 severe CONJUNCTIVAF Redness Rating Cheniosis Rating Disc/i arge Rating Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red I slight 2 mod. 3 severe Any swelling Obvious swelling with partial eversion of lids Swelling with lids half- closed Swelling with lids half- closed to completely I slight mild mod. severe Any amount different from normal Discharge ~vith moistening of lids and adjacent Discharge with moistening of lids and hairs and considerable area around eve slight mod. severe closed IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light I slight No reaction to haernorrhage, gross destruction 2 severe
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