2020 mg/kg in corn oil patches. Method of administration: Not stated. Test method: Nil Mortality: Not stated. Clinical observations: Not stated. Morphological findings: > 2020 mg/kg LD50: AG-RHO DR-2000 was of very low dermal toxicity in Result: rabbits. Acute Inhalation Toxicity No study of acute inhalation toxicity was provided by the notifier. Skin Irritation (Toxicol Laboratories Limited, Jaguar C-162 Test substance: Rabbit/New Zealand Species/strain: 6 females Number/sex of animals: 7 days Observation period: A single 4 hour, semi occluded application of 500 mg of test Method of administration: substance, moistened with to intact skin. OECD TG 404 Test method: Very slight erythema (Grade 1) was observed in one animal Cutaneous reactions: one hour after the dressings were removed. No other irritation or other effects of treatment were observed for the duration of the study. 24, 48 & 72 hour group Erythema/Eschar formulation: 0.0 mean score: Oedema: 0.0 Jaguar C-162 was non irritating to rabbit skin. Result:
Method of administration: 2020 mg/kg in corn oil patches. Test method: Not stated. Mortality: Nil Clinical observations: Not stated. Morphological findings: Not stated. LD50: > 2020 mg/kg Result: AG-RHO DR-2000 was of very low dermal toxicity in rabbits. Acute Inhalation Toxicity No study of acute inhalation toxicity was provided by the notifier. Skin Irritation (Toxicol Laboratories Limited, Test substance: Jaguar C-162 Species/strain: Rabbit/New Zealand Number/sex of animals: 6 females Observation period: 7 days Method of administration: A single 4 hour, semi occluded application of 500 mg of test substance, moistened with to intact skin. Test method: OECD TG 404 Cutaneous reactions: Very slight erythema (Grade 1) was observed in one animal one hour after the dressings were removed. No other irritation or other effects of treatment were observed for the duration of the study. 24, 48 & 72 hour group mean score: Erythema/Eschar formulation: 0.0 Oedema: 0.0 Result: Jaguar C-162 was non irritating to rabbit skin.
NA818FR.docx