9.1.1 Oral Toxicity (ref) Species/strain: rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Test Substance: RLM 45N Method of administration: a single dose of 2 000 mg.kg-1 of RLM administered by gavage; vehicle was arachis oil BP (concentration not specified) Clinical observations: none Mortality: none Morphological findings: none Test method: similar to OECD guidelines (ref) LD50: > 2 000 mg.kg-1 Result: by implication, the notified chemical was of low acute toxicity when administered orally in a limit test in rats 9.1.2 Skin Irritation (Ref) Species/strain: rabbit/Himalayan Number/sex of animals: 3 males Observation period: up to 4 days Test Substance: Akypo-Soft 45NV (as supplied, 21% notified chemical) Method of administration: 0.5 ml of the test substance was applied to intact skin for 4
9.1.1 Oral Toxicity (ref) Species/strain: Number/sex of animals: Observation period: Test Substance: Method of administration: Clinical observations: Mortality: Morphological findings: Test method: LD50: Result: 9.1.2 Skin Irritation (Ref) Species/strain: Number/sex of animals: Observation period: Test Substance: Method of administration: rat/Sprague Dawley 5/sex 14 days RLM 45N a single dose of 2 000 mg.kg-1 of RLM administered by gavage; vehicle was arachis oil BP (concentration not specified) none none none similar to OECD guidelines (ref) > 2 000 mg.kg-1 by implication, the notified chemical was of low acute toxicity when administered orally in a limit test in rats rabbit/Himalayan 3 males up to 4 days Akypo-Soft 45NV (as supplied, 21% notified chemical) 0.5 ml of the test substance was applied to intact skin for 4
NA604FR.docx