> 460 mg/kg LD50: the test material (23% notified chemical) was Result: of low dermal toxicity in rabbits. Inhalation Toxicity No studies were available. Skin Irritation (44% Notified Chemical) (Glaza, 1996f) rabbit/Hra: (NZW)SPF Species/strain: 2 males and 1 female Number/sex of animals: 72 hours Observation period: dermal application (0.5 mL) to the intact skin on Method of administration: each animal’s back; covered with a semiocclusive dressing for 4 hours similar to OECD TG 404 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) Draize scores at 24, 48 and 72 hours after Draize scores: application were zero for all animals the test material (44% notified chemical) was Result: not irritating to the skin of rabbits Skin Irritation (23% Notified Chemical) (Shapiro, 1989e) rabbit/New Zealand Albino Species/strain: 3/sex Number/sex of animals: not stated Observation period: dermal application (0.5 mL) to both intact and Method of administration: abraded skin covered with an occlusive dressing for 24 hours
LD50: > 460 mg/kg Result: the test material (23% notified chemical) was of low dermal toxicity in rabbits. Inhalation Toxicity No studies were available. Skin Irritation (44% Notified Chemical) (Glaza, 1996f) Species/strain: rabbit/Hra: (NZW)SPF Number/sex of animals: 2 males and 1 female Observation period: 72 hours Method of administration: dermal application (0.5 mL) to the intact skin on each animal’s back; covered with a semiocclusive dressing for 4 hours Test method: similar to OECD TG 404 (Organisation for Economic Co-operation and Development, 1995- 1996) Draize scores: Draize scores at 24, 48 and 72 hours after application were zero for all animals Result: the test material (44% notified chemical) was not irritating to the skin of rabbits Skin Irritation (23% Notified Chemical) (Shapiro, 1989e) Species/strain: rabbit/New Zealand Albino Number/sex of animals: 3/sex Observation period: not stated Method of administration: dermal application (0.5 mL) to both intact and abraded skin covered with an occlusive dressing for 24 hours
NA625FR.docx