and haematocrit were noted in females at all tested doses; higher incidence of abnormal red cell morphology was also observed in all treated groups; a no-observed-effect-level (NOEL) could not be determined 9.3 Genotoxicity Reverse Mutation Assay (Lawlor TE, 1992) Salmonella typhimurium TA98, TA100, TA1535, TA1537, Strains: S. typhymurium TA 1538 333, 667, 1 000, 3 300, 6 670, 10 000 g.plate-1 Concentration range: according to OECD guidelines (Organisation for Test method: Economic Co-operation and Development, the notified chemical did not cause an increase in Result: the number of revertants per plate in any of the bacterial strains tested in the presence and absence of microsomal enzyme from induced-rat liver S9 9.3.2 Chromosome Aberration Assay in Chinese Hamster Ovary (CHO) Cells (Barber ED, 1992) CHO Species/strain: with metabolic activation: Dose range: 2.5 80 g.mL-1 in 10 and 20 hours – without metabolic activation: 2.5 10 g.mL-1 in 10 hours – 7.5 20 g.mL-1 in 20 hours – according to OECD guidelines (Organisation for Test method: Economic Co-operation and Development, the notified chemical did not induce chromosomal Result: aberrations in CHO cells in the presence or absence of metabolic activation 9.4 Overall Assessment of Toxicological Data CIN 10095204 shows low acute oral and dermal toxicity in rats with LD50 values greater than 2 000 mg.kg-1 for both administration routes. CIN 10096270 is not irritant to rabbit skin; however, it caused slight irritation to the rabbit eye. CIN was not considered to be a dermal sensitiser in guinea pigs.
and haematocrit were noted in females at all tested doses; higher incidence of abnormal red cell morphology was also observed in all treated groups; a no-observed-effect-level (NOEL) could not be determined 9.3 Genotoxicity Salmonella typhimurium Reverse Mutation Assay (Lawlor TE, 1992) Strains: S. typhymurium TA98, TA100, TA1535, TA1537, TA 1538 Concentration range: 333, 667, 1 000, 3 300, 6 670, 10 000 g.plate-1 Test method: according to OECD guidelines (Organisation for Economic Co-operation and Development, Result: the notified chemical did not cause an increase in the number of revertants per plate in any of the bacterial strains tested in the presence and absence of microsomal enzyme from induced-rat liver S9 9.3.2 Chromosome Aberration Assay in Chinese Hamster Ovary (CHO) Cells (Barber ED, 1992) Species/strain: CHO Dose range: with metabolic activation: 2.5 – 80 g.mL-1 in 10 and 20 hours without metabolic activation: 2.5 – 10 g.mL-1 in 10 hours 7.5 – 20 g.mL-1 in 20 hours Test method: according to OECD guidelines (Organisation for Economic Co-operation and Development, Result: the notified chemical did not induce chromosomal aberrations in CHO cells in the presence or absence of metabolic activation 9.4 Overall Assessment of Toxicological Data CIN 10095204 shows low acute oral and dermal toxicity in rats with LD50 values greater than 2 000 mg.kg-1 for both administration routes. CIN 10096270 is not irritant to rabbit skin; however, it caused slight irritation to the rabbit eye. CIN was not considered to be a dermal sensitiser in guinea pigs.
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