all doses in a dose-related manner. Desquamation occurred mainly following erythema; necrosis was observed in one rabbit receiving a dose of 2.15 mL/kg. One rabbit in the 2.15 mL/kg dose group had pitted kidneys. Morphological findings: > 4.64 mL/kg. LD50: The test substance was of low dermal toxicity in rats. Result: 9.1.3 Inhalation Toxicity (TM-694) (Tox Monitor Laboratories, 1994) rat/Sprague-Dawley. Species/strain: 5/sex/dose group. Number/sex of animals: 2.09 and 5.45 mg/L for 4 Dose groups: 14 days. Observation period: An aerosol was produced using an atomising system in a Method of administration: 100 L clear plastic chamber. OECD TG 403 Test method: Complete mortality by day 3 in the 5.45 mg/L exposure Mortality: group. Mortality of 20% by day 4 in the 2.09 mg/L exposure group. 5.45 mg/L group: hypoactivity, wet fur in all animals, Clinical observations: uncoordinated movement in 2 males until time of death. 2.09 mg/L group: uncoordinated movement in 1 male until time of death; piloerection and hypoactivity in 1 male which died and 1 male which did not; also hypoactivity only in 1 female. 5.45 mg/L lungs red and mottled, g.i. tract distended. Morphological findings: 2.09 mg/L group: as above in 2 males but less severe. Between 2.09 and 5.45 mg/L. LC50: The notified chemical was of low acute inhalational toxicity Result: in rats. 9.1.4 Skin Irritation (TM-592) (IBR-US, 1974) rabbit/albino. Species/strain:
all doses in a dose-related manner. Desquamation occurred mainly following erythema; necrosis was observed in one rabbit receiving a dose of 2.15 mL/kg. Morphological findings: One rabbit in the 2.15 mL/kg dose group had pitted kidneys. LD50: > 4.64 mL/kg. Result: The test substance was of low dermal toxicity in rats. 9.1.3 Inhalation Toxicity (TM-694) (Tox Monitor Laboratories, 1994) Species/strain: rat/Sprague-Dawley. Number/sex of animals: 5/sex/dose group. Dose groups: 2.09 and 5.45 mg/L for 4 Observation period: 14 days. Method of administration: An aerosol was produced using an atomising system in a 100 L clear plastic chamber. Test method: OECD TG 403 Mortality: Complete mortality by day 3 in the 5.45 mg/L exposure group. Mortality of 20% by day 4 in the 2.09 mg/L exposure group. Clinical observations: 5.45 mg/L group: hypoactivity, wet fur in all animals, uncoordinated movement in 2 males until time of death. 2.09 mg/L group: uncoordinated movement in 1 male until time of death; piloerection and hypoactivity in 1 male which died and 1 male which did not; also hypoactivity only in 1 female. Morphological findings: 5.45 mg/L lungs red and mottled, g.i. tract distended. 2.09 mg/L group: as above in 2 males but less severe. LC50: Between 2.09 and 5.45 mg/L. Result: The notified chemical was of low acute inhalational toxicity in rats. 9.1.4 Skin Irritation (TM-592) (IBR-US, 1974) Species/strain: rabbit/albino.
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