: a) terminal kill no gross abnormalities Dose (mg/kg): 200 500 no abnormalities b) decedents within 4 hours of treatment 500 yellowish in the intestinal tract Dose (mg/kg): 710 haemorrhagic stomach and reddish mucoid material in the intestinal 1 000 orange mucoid material in the intestinal tract reddish mucoid material in the intestinal 2 000 tract and one animal also had stomach haemorrhagic c) decedents within 24 hours of haemorrhagic stomach and treatment 1 000 orange mucoid material in the intestinal Dose (mg/kg): tract according to the Environmental Protection Agency Test method: Health Effects Testing Guidelines (40 CFR, Section 163-81-1 Federal Register), which is similar to OECD test guideline (Organisation for Economic Cooperation and Development, 1987c) males: 590 mg/kg LD50: females: 540 mg/kg the notified chemical was of low oral toxicity Result: in rats Dermal Toxicity (Costello, 1984a) rabbit/New Zealand White Species/strain: 5/sex/dose Number/sex of animals: 14 days Observation period: 200 or 2 000 mg/kg of test substance held under Method of administration: occlusive dressing; after 24 hours, excess material was wiped away
Dose (mg/kg): 200 a) terminal kill no gross abnormalities 500 no abnormalities Dose (mg/kg): 500 b) decedents within 4 hours of treatment yellowish in the intestinal tract 710 1 000 haemorrhagic stomach and reddish mucoid material in the intestinal orange mucoid material in the intestinal tract 2 000 reddish mucoid material in the intestinal tract and one animal also had haemorrhagic stomach Dose (mg/kg): 1 000 c) decedents within 24 hours of treatment haemorrhagic stomach and orange mucoid material in the intestinal tract Test method: according to the Environmental Protection Agency Health Effects Testing Guidelines (40 CFR, Section 163-81-1 Federal Register), which is similar to OECD test guideline (Organisation for Economic Cooperation and Development, 1987c) LD50: males: 590 mg/kg females: 540 mg/kg Result: the notified chemical was of low oral toxicity in rats Dermal Toxicity (Costello, 1984a) Species/strain: rabbit/New Zealand White Number/sex of animals: 5/sex/dose Observation period: 14 days Method of administration: 200 or 2 000 mg/kg of test substance held under occlusive dressing; after 24 hours, excess material was wiped away :
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