9.2.1. Inhalation Toxicity Test Substance LC50 Toxic Effects Analogue B 1 700 mg/m3/4 hour; Lacrimation, dyspnoea, changes in structure or function of salivary gland. Analogue C 1 640 mg/m3/4 hour; Somnolence, dyspnoea, weight loss or decreased weight gain. Skin Irritation (Pharma Research Toxicology and Pathology 1987) Analogue A Test substance: Rabbit/New Zealand Species/strain: 3 Number of animals: 7 days Observation period: A semi-occlusive application of 0.5 mL undiluted test Method of administration: substance was made on the dorsal skin. After 4 hours, the substance carefully removed with tap water. OECD TG 404 Test method: Draize scores: Time after Animal # Erythema treatment (days) 1 2 3 1 2 3 a2 2 2 2 2 3 0 2 2 Oedema 1 1 0 1 2 1 0 1 3 0 0 0 see Attachment 1 for Draize scales a
9.2.1. Inhalation Toxicity Test Substance LC50 Toxic Effects Analogue B 1 700 mg/m3/4 hour; Lacrimation, dyspnoea, changes in structure or function of salivary gland. Analogue C 1 640 mg/m3/4 hour; Somnolence, dyspnoea, weight loss or decreased weight gain. Skin Irritation (Pharma Research Toxicology and Pathology 1987) Test substance: Analogue A Species/strain: Rabbit/New Zealand Number of animals: 3 Observation period: 7 days Method of administration: A semi-occlusive application of 0.5 mL undiluted test substance was made on the dorsal skin. After 4 hours, the substance carefully removed with tap water. Test method: OECD TG 404 Draize scores: Time after Animal # treatment (days) Erythema 1 2 3 1 a2 2 3 2 2 2 2 3 0 2 2 Oedema 1 1 0 1 2 1 0 1 3 0 0 0 a see Attachment 1 for Draize scales
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