rabbits normal; by 48 hours, necrosis in one rabbit and a blanched area surrounded by erythema in another rabbit; it was concluded that the test substance was corrosive in two rabbits; observations up to 48 hours revealed necrosis at the test site in all rabbits; observations up to 48 revealed no necrosis at the test site and barely perceptible to slight erythema and oedema in 5 rabbits and no reaction in another rabbit it was concluded that, the adhesive pad, “Coverlet” the test material was held tightly against the skin with possibly enhanced humidity leading to hydrolysis and the production of acetic acid which is corrosive Eye Irritation (Edmonds, 1967a) No. 1 rabbit/New Zealand White Species/strain: 3/sex Number/sex of animals: 72 hours Observation period: 0.1 g of the test substance into the right eye of each Method of administration: animal similar to OECD guidelines (Organisation for Test method: Economic Co-operation and Development, 1995-1996) severe corneal, iridal and conjunctival effects were Result: seen in all animals at all time points the notified chemical was a severe eye irritant in rabbits (Budd, 1967) Study No. 2 rabbit/albino Species/strain: 3/sex for each of two tests, one with a 15 minute Number/sex of animals: washout after 5 minutes 72 Observation period: 0.1 g of the test substance into the right eye of each Method of administration: animal
rabbits normal; by 48 hours, necrosis in one rabbit and a blanched area surrounded by erythema in another rabbit; it was concluded that the test substance was corrosive in two rabbits; observations up to 48 hours revealed necrosis at the test site in all rabbits; observations up to 48 revealed no necrosis at the test site and barely perceptible to slight erythema and oedema in 5 rabbits and no reaction in another rabbit it was concluded that, the “Coverlet” adhesive pad, the test material was held tightly against the skin with possibly enhanced humidity leading to hydrolysis and the production of acetic acid which is corrosive Eye Irritation No. 1 (Edmonds, 1967a) Species/strain: rabbit/New Zealand White Number/sex of animals: 3/sex Observation period: 72 hours Method of administration: 0.1 g of the test substance into the right eye of each animal Test method: similar to OECD guidelines (Organisation for Economic Co-operation and Development, 1995-1996) Result: severe corneal, iridal and conjunctival effects were seen in all animals at all time points the notified chemical was a severe eye irritant in rabbits Study No. 2 (Budd, 1967) Species/strain: rabbit/albino Number/sex of animals: 3/sex for each of two tests, one with a 15 minute washout after 5 minutes Observation period: 72 Method of administration: 0.1 g of the test substance into the right eye of each animal
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