2-8902 Rat LD50 > 1.16 mg/L Sullivan and Rajendran (1997) Skin irritation 2-8075 Rabbit Severe irritant DeVries and Siddiqui Eye irritation 2-8075 Rabbit Moderate irritant DeVries and Siddiqui (1981c) Skin 2-8902 Guinea pig Weakly sensitising Findlay and sensitisation Bradshaw (1997); 2-8075 Guinea pig Blaszcak (1999) Not sensitising 9.1.1 Oral Toxicity (DeVries and Siddiqui, 1981d) Rat/Sprague-Dawley Species/strain: 5 males, 5 females Number/sex of animals: Dow Corning 2-8075 Test substance: 14 days Observation period: Gavage Method of administration: OECD TG 401 Test method: none Mortality: none Clinical observations: none Morphological findings: > 5000 mg/kg LD50: The test substance was of very low acute oral toxicity in rats Result: 9.1.2 Dermal Toxicity (DeVries and Siddiqui, 1981b) Rabbits/New Zealand Species/strain: 5 5 females Number/sex of animals: Dow Corning 2-8075 Test substance: 14 days Observation period: Single 2000 mg/kg dose of neat test substance applied to Method of administration: intact skin and held in place for 24 hours by a porous gauze dressing.
2-8902 Rat LD50 > 1.16 mg/L Sullivan and Rajendran (1997) Skin irritation 2-8075 Rabbit Severe irritant DeVries and Siddiqui Eye irritation 2-8075 Rabbit Moderate irritant DeVries and Siddiqui (1981c) Skin sensitisation 2-8902 2-8075 Guinea pig Guinea pig Weakly sensitising Not sensitising Findlay and Bradshaw (1997); Blaszcak (1999) 9.1.1 Oral Toxicity (DeVries and Siddiqui, 1981d) Species/strain: Rat/Sprague-Dawley Number/sex of animals: 5 males, 5 females Test substance: Dow Corning 2-8075 Observation period: 14 days Method of administration: Gavage Test method: OECD TG 401 Mortality: none Clinical observations: none Morphological findings: none LD50: > 5000 mg/kg Result: The test substance was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (DeVries and Siddiqui, 1981b) Species/strain: Rabbits/New Zealand Number/sex of animals: 5 5 females Test substance: Dow Corning 2-8075 Observation period: 14 days Method of administration: Single 2000 mg/kg dose of neat test substance applied to intact skin and held in place for 24 hours by a porous gauze dressing.
NA764FR.docx