Rabbits/New Zealand White Species/strain: 3/female Number/sex of animals: 3 days Observation period: A single dermal dose of 500 mg notified chemical Method of administration: (moistened with 0.5mL deionised water) was applied under an occlusive dressing for 4 hours. OECD TG 404 Test method: Histological examination was conducted on skin samples Comment: from the application sites of all animals due to black or black/green staining during the study. The staining prevented an accurate evaluation of irritation, as erythema could not be measured. There were no signs of oedema in any animals. Histological examination revealed no evidence of irritant effects. the notified chemical was not irritating to the skin of rabbits Result: 9.1.5 Eye Irritation (Noakes, 1999b) Rabbit/New Zealand White Species/strain: 3/female Number/sex of animals: 3 days Observation period: A single dose (approximately 100 mg notified chemical) was Method of administration: placed into the conjunctival sac of the left eye of each animal. The eyes remained unwashed. The untreated eye served as a control. OECD TG 405 Test method: Draize scores of unirrigated eyes:
Species/strain: Rabbits/New Zealand White Number/sex of animals: 3/female Observation period: 3 days Method of administration: A single dermal dose of 500 mg notified chemical (moistened with 0.5mL deionised water) was applied under an occlusive dressing for 4 hours. Test method: OECD TG 404 Comment: Histological examination was conducted on skin samples from the application sites of all animals due to black or black/green staining during the study. The staining prevented an accurate evaluation of irritation, as erythema could not be measured. There were no signs of oedema in any animals. Histological examination revealed no evidence of irritant effects. Result: the notified chemical was not irritating to the skin of rabbits 9.1.5 Eye Irritation (Noakes, 1999b) Species/strain: Rabbit/New Zealand White Number/sex of animals: 3/female Observation period: 3 days Method of administration: A single dose (approximately 100 mg notified chemical) was placed into the conjunctival sac of the left eye of each animal. The eyes remained unwashed. The untreated eye served as a control. Test method: OECD TG 405 Draize scores of unirrigated eyes:
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