Soft stools were noted in 7 animals within 4 hours of Clinical observations: treatment. Dark staining of the urogenital region was observed in all animals on days 1 and 2. No other signs of toxicity were observed. No treatment-related macroscopic findings were observed. Morphological findings: > 5000 mg/kg LD50: The test chemical is of very low acute oral toxicity in rats. Result: 9.1.2 Dermal Toxicity (Glaza, 1993b) Rat / Crl: CDrBR Species/strain: 5 males and 5 females Number/sex of animals: 14 days Observation period: 2000 mg/kg liquid chemical applied undiluted occlusive Method of administration: dressing. OECD TG 402 (Limit Study) Test method: None Mortality: No signs of local or systemic toxicity were observed. Clinical observations: No treatment-related macroscopic findings were observed. Morphological findings: > 2000 mg/kg LD50: The test chemical is of low dermal toxicity in rats. Result: 9.1.3 Inhalation Toxicity Study not conducted for this viscous liquid of low volatility. (Glaza, 1993c) 9.1.4 Skin Irritation Rabbit / Hra: (NZW) SPF Species/strain: 3 and 3 females Number/sex of animals: Up to 96 Observation period:
Clinical observations: Soft stools were noted in 7 animals within 4 hours of treatment. Dark staining of the urogenital region was observed in all animals on days 1 and 2. No other signs of toxicity were observed. Morphological findings: No treatment-related macroscopic findings were observed. LD50: > 5000 mg/kg Result: The test chemical is of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Glaza, 1993b) Species/strain: Rat / Crl: CDrBR Number/sex of animals: 5 males and 5 females Observation period: 14 days Method of administration: 2000 mg/kg liquid chemical applied undiluted occlusive dressing. Test method: OECD TG 402 (Limit Study) Mortality: None Clinical observations: No signs of local or systemic toxicity were observed. Morphological findings: No treatment-related macroscopic findings were observed. LD50: > 2000 mg/kg Result: The test chemical is of low dermal toxicity in rats. 9.1.3 Inhalation Toxicity Study not conducted for this viscous liquid of low volatility. 9.1.4 Skin Irritation (Glaza, 1993c) Species/strain: Rabbit / Hra: (NZW) SPF Number/sex of animals: 3 and 3 females Observation period: Up to 96
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