Indications. Fomepizole is recommended for the management of EG poisoning. It is also used as an antidote for methanol intoxication (Lexi Comp., 2013) Contraindications. Fomepizole is contraindicated in patients with history of hypersensitivity to the drug (Lexi Comp., 2013). Dosage. Initially Fomepizole is given as a loading dose of 15 mg/kg intravenously (IV). Subsequently the dose consists of 10 mg/kg IV administered every 12 hours for 4 doses. Further dosages consist of 15 mg/kg every 12 hours while waiting for EG levels to decline to <20 mg/dL, witness improvement of patient’s symptoms, and normalization of pH (Lexi comp., 2013). If patient develops renal failure and requires hemodialysis, adjustment of dosage is required (Lexi Comp, 2013). Precautions. Fomepizole should be administered carefully in patients with liver and kidney impairment since the drug is metabolized in the liver and excreted by the kidneys. If severe kidney impairment is noted, and when ingested levels of EG are high, hemodialysis may be necessary (Lexi Comp., 2013). Fomepizole should always be administered diluted in 100 ml of 0.9% Administration. sodium chloride or 5% dextrose solution, and as a slow IV infusion over a period of half hour. Fomepizole should never be given as a bolus (Lexi Comp., 2013). Adverse Effects. Fomepizole can cause the following adverse effects, headache, GI distress, cardiac dysrhythmia, hypotension, rash, elevated liver enzymes, anemia, phlebitis, arthralgia, visual changes, anuria, hiccups, pharyngitis, and multi organ failure (Lexi Comp, 2013). Drug Concentration. Literature supports Fomepizole levels of greater than 0.8 mg/L is sufficient to deliver continuous inhibition of the enzyme ADH (Lexi Comp., 2013).
Indications. Fomepizole is recommended for the management of EG poisoning. It is also used as an antidote for methanol intoxication (Lexi Comp., 2013) Contraindications. Fomepizole is contraindicated in patients with history of hypersensitivity to the drug (Lexi Comp., 2013). Dosage. Initially Fomepizole is given as a loading dose of 15 mg/kg intravenously (IV). Subsequently the dose consists of 10 mg/kg IV administered every 12 hours for 4 doses. Further dosages consist of 15 mg/kg every 12 hours while waiting for EG levels to decline to <20 mg/dL, witness improvement of patient’s symptoms, and normalization of pH (Lexi comp., 2013). If patient develops renal failure and requires hemodialysis, adjustment of dosage is required (Lexi Comp, 2013). Precautions. Fomepizole should be administered carefully in patients with liver and kidney impairment since the drug is metabolized in the liver and excreted by the kidneys. If severe kidney impairment is noted, and when ingested levels of EG are high, hemodialysis may be necessary (Lexi Comp., 2013). Administration. Fomepizole should always be administered diluted in 100 ml of 0.9% sodium chloride or 5% dextrose solution, and as a slow IV infusion over a period of half hour. Fomepizole should never be given as a bolus (Lexi Comp., 2013). Adverse Effects. Fomepizole can cause the following adverse effects, headache, GI distress, cardiac dysrhythmia, hypotension, rash, elevated liver enzymes, anemia, phlebitis, arthralgia, visual changes, anuria, hiccups, pharyngitis, and multi organ failure (Lexi Comp, 2013). Drug Concentration. Literature supports Fomepizole levels of greater than 0.8 mg/L is sufficient to deliver continuous inhibition of the enzyme ADH (Lexi Comp., 2013).
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