Summary of the acute toxicity of IPD, m-XDA, DETA and TETA Test Species Outcome Reference acute oral toxicity rat LD50: 660 or 930 mg.kg-1 (m-XDA) (1) 080 mg.kg-1 (DETA) (1) 500 mg.kg-1 (TETA) (2) dermal toxicity rabbit LD50: 2 000 mg.kg-1 (m-XDA) (1) 1 090 mg.kg-1 (DETA) (1) 805 mg.kg-1 (TETA) (2) (1 hour) (m- XDA); equivalent to inhalation 4 hour LC50 of (1) toxicity 1.9 mg.L-1; ocular irritation, lacrimation and dyspnoea observed; lung, liver and kidney rat LC50 macroscopic changes = DETA: no mortality after 8 hour 3.75 exposure to 300 ppm (1) (1) skin irritation guinea severe irritant (m-XDA at 10% and pig 50%) (1) severe irritant (DETA) rabbit severe irritant (TETA) (2) (2) corrosive (m-XDA) eye irritation rabbit irritant (m-XDA) (1) severe irritant (DETA) (2) severe irritant (TETA) (2) skin sensitisation human skin sensitiser: IPD (3, 4) (1) (1) DETA (5) TETA (1) respiratory sensitiser: DETA Repeat Dose Toxicity - 90-Day Feeding Study (6) A 90-day repeat dose toxicity of TETA, a medical chelating agent, in the drinking water of rats and mice was conducted to identify and characterise
Summary of the acute toxicity of IPD, m-XDA, DETA and TETA Test Species Outcome Reference acute oral toxicity rat LD50: 660 or 930 mg.kg-1 (m-XDA) 080 mg.kg-1 (DETA) 500 mg.kg-1 (TETA) (1) (1) (2) dermal toxicity rabbit LD50: 2 000 mg.kg-1 (m-XDA) 1 090 mg.kg-1 (DETA) 805 mg.kg-1 (TETA) (1) (1) (2) inhalation toxicity rat LC50 = 3.75 (1 hour) (m- XDA); equivalent to 4 hour LC50 of 1.9 mg.L-1; ocular irritation, lacrimation and dyspnoea observed; lung, liver and kidney macroscopic changes DETA: no mortality after 8 hour exposure to 300 ppm (1) (1) skin irritation guinea pig rabbit corrosive (m-XDA) severe irritant (m-XDA at 10% and 50%) severe irritant (DETA) severe irritant (TETA) (1) (1) (2) (2) eye irritation rabbit irritant (m-XDA) severe irritant (DETA) severe irritant (TETA) (1) (2) (2) skin sensitisation human skin sensitiser: IPD DETA TETA respiratory sensitiser: DETA (3, 4) (1) (1) (5) (1) Repeat Dose Toxicity - 90-Day Feeding Study (6) A 90-day repeat dose toxicity of TETA, a medical chelating agent, in the drinking water of rats and mice was conducted to identify and characterise
NA565FR.docx