Skin Irritation (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 rabbit/New Zealand White Species/strain: 3/sex Number/sex of animals: 72 Observation period: 0.5 mL of undiluted test substance under semi- Method of administration: occlusive dressing for 4 EEC Method B4 Test method: the notified chemical was not a skin irritant in Result: rabbits; no erythema or oedema was observed in any animal at any time point Shell Brake Fluid Dot 4 Super rabbit/New Zealand White Species/strain: 3/sex Number/sex of animals: 72 hours Observation period: 0.5 mL of undiluted test substance under semi- Method of administration: occlusive dressing for 4 hours OECD TG 404 Test method: the notified chemical was not a skin irritant in Result: rabbits; no erythema or oedema was observed in any animal at any time point Eye Irritation (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 rabbit/New Zealand White Species/strain: 3/sex Number/sex of animals: 72 hours Observation period: 0.1 mL of undiluted test substance into the lower Method of administration: conjunctival sac of one eye of each animal
Skin Irritation (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 Species/strain: rabbit/New Zealand White Number/sex of animals: 3/sex Observation period: 72 Method of administration: 0.5 mL of undiluted test substance under semi- occlusive dressing for 4 Test method: EEC Method B4 Result: the notified chemical was not a skin irritant in rabbits; no erythema or oedema was observed in any animal at any time point Shell Brake Fluid Dot 4 Super Species/strain: rabbit/New Zealand White Number/sex of animals: 3/sex Observation period: 72 hours Method of administration: 0.5 mL of undiluted test substance under semi- occlusive dressing for 4 hours Test method: OECD TG 404 Result: the notified chemical was not a skin irritant in rabbits; no erythema or oedema was observed in any animal at any time point Eye Irritation (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 Species/strain: rabbit/New Zealand White Number/sex of animals: 3/sex Observation period: 72 hours Method of administration: 0.1 mL of undiluted test substance into the lower conjunctival sac of one eye of each animal
NA657FR.docx