28 day, oral; 0, 50, NOEL=50 Clinical signs, reduced 200,1000 (subchronic) bodyweight gains and changes (WIL Research in organ weights. Laboratories Inc 1993) NOAEL 1000 Highest dose tested. (neurotoxicity) NOEL=50 Reduced bodyweights, and (reproductive) decrease in live litter size. 28 day, dermal; 0, 20, 100, NOEL 250 Highest dose tested. 250 (dermal) (SOCAL 1986) Developmental, oral; 0, 50, 300, NOEL=300 Reduced bodyweight gains 1000 (parental) and food consumption. (CEHC 1990) NOEL=50 Malformation. (developmental) Developmental, oral; 0, 50, 300, NOEL=300 Reduced bodyweights and 1000 (parental). food consumption. (WIL Research Laboratories 1994) NOEL=300 Malformation. (developmental) Oral, two-generation; 0, 50, 300, NOAEL=50 Mortality, clinical signs, 1000 (parental) reduced bodyweight gains, and (WIL Research changes of organ weights. Laboratories 1995b) NOAEL=300 Lower fertility indices. (reproductive) NOAEL=50 Lower pup survival rates, live (developmental) litter sizes and pup bodyweights. Oral reproductive & 0, 50, 250 NOEL 250 Highest dose tested developmental; (in finished (reproductive & (WIL Research oil) developmental) Laboratories 9.3 Genotoxicity 9.3.1 Reverse Mutation Assay (Chevron Environmental Health Salmonella typhimurium Center Inc 1986b) XA-294C (OLOA 319) Test Substance: TA100, TA1535, TA98, Strains: Salmonella typhimurium: TA1537 Auxillary metabolic Liver S9 fraction from rats induced with Aroclor 1254 activation system:
28 day, oral; (WIL Research Laboratories Inc 1993) 0, 50, 200,1000 NOEL=50 (subchronic) NOAEL 1000 (neurotoxicity) NOEL=50 (reproductive) Clinical signs, reduced bodyweight gains and changes in organ weights. Highest dose tested. Reduced bodyweights, and decrease in live litter size. 28 day, dermal; (SOCAL 1986) 0, 20, 100, 250 NOEL 250 (dermal) Highest dose tested. Developmental, oral; (CEHC 1990) 0, 50, 300, 1000 NOEL=300 (parental) NOEL=50 (developmental) Reduced bodyweight gains and food consumption. Malformation. Developmental, oral; (WIL Research Laboratories 1994) 0, 50, 300, 1000 NOEL=300 (parental). NOEL=300 (developmental) Reduced bodyweights and food consumption. Malformation. Oral, two-generation; (WIL Research Laboratories 1995b) 0, 50, 300, 1000 NOAEL=50 (parental) NOAEL=300 (reproductive) NOAEL=50 (developmental) Mortality, clinical signs, reduced bodyweight gains, and changes of organ weights. Lower fertility indices. Lower pup survival rates, live litter sizes and pup bodyweights. Oral reproductive & developmental; (WIL Research Laboratories 0, 50, 250 (in finished oil) NOEL 250 (reproductive & developmental) Highest dose tested 9.3 Genotoxicity 9.3.1 Salmonella typhimurium Reverse Mutation Assay (Chevron Environmental Health Center Inc 1986b) Test Substance: XA-294C (OLOA 319) Strains: Salmonella typhimurium: TA100, TA1535, TA98, TA1537 Auxillary metabolic activation system: Liver S9 fraction from rats induced with Aroclor 1254
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