Acute oral toxicity Rat LD50 > 4 168mg/kg bw Acute dermal toxicity Rat LD50 > 2 000 mg/kg bw Skin irritation Rabbit Mildly irritating Eye irritation Rabbit Mildly irritating Skin sensitisation non Guineapig – Non sensitising adjuvant method Bacterial Reverse Mutation S .typhimurium Non mutagenic 9.1 Acute Toxicity 9.1.1.1 Oral Toxicity (Safepharm Laboratories Limited Alkane 5 Test Substance: Rat/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: 5 000 mg/kg by gavage in a dose volume of 6.07 mL/kg Method of administration: OECD TG 401; EC Method B1 Test method: Nil Mortality: There were no clinical signs of systemic toxicity. Clinical observations: No abnormalities were noted at necropsy. Morphological findings: > 5 000 mg/kg Estimated LD50: Alkane 5 was of very low acute oral toxicity to the rat. Result: 9.1.1.2 Oral Toxicity (Hazelton Raltech Inc 1982b) Oronite Gulf Synfluid 8cSt Test Substance: Rat/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: 4 168 mg/kg by gavage in a dose volume of 5.0 mL/kg bw Method of administration:
Acute oral toxicity Rat LD50 > 4 168mg/kg bw Acute dermal toxicity Rat LD50 > 2 000 mg/kg bw Skin irritation Rabbit Mildly irritating Eye irritation Rabbit Mildly irritating Skin sensitisation – non adjuvant method Guineapig Non sensitising Bacterial Reverse Mutation S .typhimurium Non mutagenic 9.1 Acute Toxicity 9.1.1.1 Oral Toxicity (Safepharm Laboratories Limited Test Substance: Alkane 5 Species/strain: Rat/Sprague-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: 5 000 mg/kg by gavage in a dose volume of 6.07 mL/kg Test method: OECD TG 401; EC Method B1 Mortality: Nil Clinical observations: There were no clinical signs of systemic toxicity. Morphological findings: No abnormalities were noted at necropsy. Estimated LD50: > 5 000 mg/kg Result: Alkane 5 was of very low acute oral toxicity to the rat. 9.1.1.2 Oral Toxicity (Hazelton Raltech Inc 1982b) Test Substance: Oronite Gulf Synfluid 8cSt Species/strain: Rat/Sprague-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: 4 168 mg/kg by gavage in a dose volume of 5.0 mL/kg bw
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