EVALUATION OF TOXICOLOGICAL DATA Tests were performed according to OECD test guidelines (OECD 1995-1996) at facilities complying with OECD Principles of Good Laboratory Practice. Toxicity Summary of the acute toxicity of LumiNova Test Species Outcome Reference acute oral toxicity rat > 2 000 mg/kg (McRae, 1995) acute dermal toxicity rat > 2 000 mg/kg (McRae, 1995) skin irritation rabbit non irritant (Parcell, 1995) eye irritation rabbit slight irritant (Parcell, 1995) skin sensitisation guinea pig non sensitising (Allan, 1995) Oral Toxicity (McRae, 1995) rat/ Sprague Dawley (CD) Species/strain: 5/sex per group Number/sex of animals: 15 days Observation period: a single dose of 2 000 mg/kg (20% w/v solution in corn oil) Method of administration: administered by gavage OECD TG 401 Test Test method: – pilo-erection was observed in all animals through to Day 2 Clinical observations: none Mortality: none Morphological findings: > 2 000 mg/kg LD50: the notified chemical was of very low oral toxicity in Result: rats
EVALUATION OF TOXICOLOGICAL DATA Tests were performed according to OECD test guidelines (OECD 1995-1996) at facilities complying with OECD Principles of Good Laboratory Practice. Toxicity Summary of the acute toxicity of LumiNova Test Species Outcome Reference acute oral toxicity rat > 2 000 mg/kg (McRae, 1995) acute dermal toxicity skin irritation rat rabbit > 2 000 mg/kg non irritant (McRae, 1995) (Parcell, 1995) eye irritation skin sensitisation rabbit guinea pig slight irritant non sensitising (Parcell, 1995) (Allan, 1995) Oral Toxicity (McRae, 1995) Species/strain: rat/ Sprague Dawley (CD) Number/sex of animals: 5/sex per group Observation period: 15 days Method of administration: a single dose of 2 000 mg/kg (20% w/v solution in corn oil) administered by gavage Test method: OECD TG 401 – Test Clinical observations: pilo-erection was observed in all animals through to Day 2 Mortality: none Morphological findings: none LD50: > 2 000 mg/kg Result: the notified chemical was of very low oral toxicity in rats
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