acute oral toxicity rat LD50 > 5 000 mg/kg (Chevron, acute dermal toxicity rat LD50 > 5 000 mg/kg (Chevron, skin irritation rabbit slight irritant (Chevron, 1985c) eye irritation rabbit slight irritant (Chevron, skin sensitisation guinea pig sensitising (OLOA 224, (Chevron, 1993; OLOA 2990, OLOA Hill Top Biolabs, 2000, XA 14328) or not 1991, 1995; Hill sensitising (16.1% Top Research, OLOA 2990) 1996; TKL Research, 1992) 9.1.1 Oral Toxicity (Chevron, Rat/Sprague-Dawley. Species/strain: 5/sex. Number/sex of animals: 14 days. Observation period: Oral (gavage); vehicle: peanut oil; dose: 5 g/kg. Method of administration: OECD TG 401 Test method: None. Mortality: The majority of animals exhibited pale or soft faeces on days Clinical observations: 1 and/or 2. None related to treatment. Morphological findings: > 5 000 mg/kg LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Chevron, Rabbit/New Zealand White (NZW). Species/strain: 4 females, 6 males initially and a fifth female 3 weeks later. Number/sex of animals: 14 days. Observation period: Under occlusive dressing for 24 hours; dose 5g/kg. Method of administration: OECD TG 402 Test method:
acute oral toxicity rat LD50 > 5 000 mg/kg (Chevron, acute dermal toxicity rat LD50 > 5 000 mg/kg (Chevron, skin irritation rabbit slight irritant (Chevron, 1985c) eye irritation rabbit slight irritant (Chevron, skin sensitisation guinea pig sensitising (OLOA 224, OLOA 2990, OLOA 2000, XA 14328) or not sensitising (16.1% OLOA 2990) (Chevron, 1993; Hill Top Biolabs, 1991, 1995; Hill Top Research, 1996; TKL Research, 1992) 9.1.1 Oral Toxicity (Chevron, Species/strain: Rat/Sprague-Dawley. Number/sex of animals: 5/sex. Observation period: 14 days. Method of administration: Oral (gavage); vehicle: peanut oil; dose: 5 g/kg. Test method: OECD TG 401 Mortality: None. Clinical observations: The majority of animals exhibited pale or soft faeces on days 1 and/or 2. Morphological findings: None related to treatment. LD50: > 5 000 mg/kg Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Chevron, Species/strain: Rabbit/New Zealand White (NZW). Number/sex of animals: 4 females, 6 males initially and a fifth female 3 weeks later. Observation period: 14 days. Method of administration: Under occlusive dressing for 24 hours; dose 5g/kg. Test method: OECD TG 402
NA892FR.docx