Skin Corrosion (Nitka, 1983) The study was conducted using the analogue F. rabbit/New Zealand Species/strain: 6/sex not known Number/sex of animals: 7 days Observation period: 0.5 mL of test substance as supplied was applied to one site, Method of administration: and held under semi-occlusive dressing; after 4 hours residual test substance was removed from the skin; test sites were examined for evidence of corrosion and graded at approximately 24, 48 hours and 7 days after treatment; Consumer Product Testing (Fairfield, New Jersey, 1980); Test method: Draize, 1975 Draize scores (Draize, 1959): Rabbit 4 hours 24 48 hours 7 days Number E1 Ed E1 Ed E1 Ed E1 Ed 1 3 4B 4 4B 4 4BC 4 4C 2 3 4B 4 4B 4 4BC 4 4C 3 3 3B 4 4B 4 4B 4 4C 4 2 3B 4 4B 4 4BC 4 4C 5 3 3B 3 3B 4 4B 4 4C 6 3 2B 4 3B 4 4B 4 4C B Blanching (loss of colour; skin is pale, grey-white) E1 erythema; Ed edema C crust (scab, dried exudate on the surface of a lesion) severe erythema and edema was observed in all animals at 2 Comment: and 7 days; and blanching observed at 4, 24 and 48 hour, crust formation was observed in 3 animals at 48 hours and in all animals after 7 days F was corrosive to the skin of rabbits Result: 9.1.6 Eye Irritation (Burnette, 1980) The study was conducted using the analogue F. rabbit/New Zealand Species/strain: 6/sex not identified Number/sex of animals:
Skin Corrosion (Nitka, 1983) The study was conducted using the analogue F. Species/strain: rabbit/New Zealand Number/sex of animals: 6/sex not known Observation period: 7 days Method of administration: 0.5 mL of test substance as supplied was applied to one site, and held under semi-occlusive dressing; after 4 hours residual test substance was removed from the skin; test sites were examined for evidence of corrosion and graded at approximately 24, 48 hours and 7 days after treatment; Test method: Consumer Product Testing (Fairfield, New Jersey, 1980); Draize, 1975 Draize scores (Draize, 1959): Rabbit Number 4 hours E1 Ed 24 E1 Ed 48 hours E1 Ed 7 days E1 Ed 1 3 4B 4 4B 4 4BC 4 4C 2 3 4B 4 4B 4 4BC 4 4C 3 3 3B 4 4B 4 4B 4 4C 4 2 3B 4 4B 4 4BC 4 4C 5 3 3B 3 3B 4 4B 4 4C 6 3 2B 4 3B 4 4B 4 4C B Blanching (loss of colour; skin is pale, grey-white) E1 erythema; Ed edema C crust (scab, dried exudate on the surface of a lesion) Comment: severe erythema and edema was observed in all animals at 2 and 7 days; and blanching observed at 4, 24 and 48 hour, crust formation was observed in 3 animals at 48 hours and in all animals after 7 days Result: F was corrosive to the skin of rabbits 9.1.6 Eye Irritation (Burnette, 1980) The study was conducted using the analogue F. Species/strain: rabbit/New Zealand Number/sex of animals: 6/sex not identified
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