EVALUATION OF TOXICOLOGICAL DATA All toxicology studies were performed using TKA 40116. Toxicity Summary of the toxicity of TKA 40116 Test Species Outcome Reference acute oral toxicity rat LD50 > 2 000 mg/kg (McRae & Mason, 1995) acute dermal toxicity rat LD50 > 2 000 mg/kg (Arcelin, 1997) skin irritation rabbit slight to moderate (Parcell, 1995b) irritant eye irritation rabbit slight irritant (Parcell, 1995a) skin sensitisation guinea pig non-sensitiser (Allan, 1995) Oral Toxicity (McRae & Mason, 1995) rat/Sprague-Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: gavage Method of administration: piloerection in all rats within seven minutes of Clinical observations: dosing and over five days none Mortality: none Morphological findings: EEC Method B.1 (European Economic Test method: Community, 1992) > 2 000 mg/kg LD50: the notified chemical was of very low acute oral Result: toxicity in rats
EVALUATION OF TOXICOLOGICAL DATA All toxicology studies were performed using TKA 40116. Toxicity Summary of the toxicity of TKA 40116 Test Species Outcome Reference acute oral toxicity rat LD50 > 2 000 mg/kg (McRae & Mason, 1995) acute dermal toxicity rat LD50 > 2 000 mg/kg (Arcelin, 1997) skin irritation rabbit slight to moderate irritant (Parcell, 1995b) eye irritation rabbit slight irritant (Parcell, 1995a) skin sensitisation guinea pig non-sensitiser (Allan, 1995) Oral Toxicity (McRae & Mason, 1995) Species/strain: rat/Sprague-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: gavage Clinical observations: piloerection in all rats within seven minutes of dosing and over five days Mortality: none Morphological findings: none Test method: EEC Method B.1 (European Economic Community, 1992) LD50: > 2 000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats
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