0.064 0.001 0.154 0.069 | trend pre, treat - trend pre, control | = 0.2 sd y | trend pre, treat - trend pre, control | = 0.160 0.003 0.204 0.265 0.4 sd y Note: Results are from 10 000 simulation iterations Note: sd=standard deviation. Note: SG-ITSA: single group interrupted time-series analysis; MG-ITSA: multi-group interrupted time-series analysis; AMI: acute myocardial infarction Table 3. Coverage values for estimators and study outcomes Estimator Outcome DID DID w/matching SG-ITSA MG-ITSA standard Clinical process Overall 0.123 0.909 0.044 0.233 | trend pre, treat - trend pre, control | = 0.281 0.941 0.000 0.764 0 | trend pre, treat - trend pre, control | = 0.059 0.897 0.011 0.038 0.2 sd y 0.007 0.829 0.950 0.000 | trend pre, treat - trend pre, control | = 0.4 sd y 30 day mortality, AMI Overall 0.138 0.900 0.193 0.233 | trend pre, treat - trend pre, control | = 0.212 0.943 0.590 0.581 0 | trend pre, treat - trend pre, control | = 0.128 0.895 0.079 0.134 0.2 sd y 0.070 0.815 0.005 0.017 | trend pre, treat - trend pre, control | = 0.4 sd y 30 day mortality, heart failure Overall 0.155 0.889 0.164 0.221 | trend pre, treat - trend pre, control | = 0.218 0.946 0.546 0.674 0 | trend pre, treat - trend pre, control | = 0.141 0.874 0.050 0.072 0.2 sd y
| trend pre, treat - trend pre, control | = 0.2 sd y 0.064 0.001 0.154 0.069 | trend pre, treat - trend pre, control | = 0.4 sd y 0.160 0.003 0.204 0.265 Note: Results are from 10 000 simulation iterations Note: sd=standard deviation. Note: SG-ITSA: single group interrupted time-series analysis; MG-ITSA: multi-group interrupted time-series analysis; AMI: acute myocardial infarction Table 3. Coverage values for estimators and study outcomes Estimator Outcome DID standard DID w/matching SG-ITSA MG-ITSA Clinical process Overall 0.123 0.909 0.044 0.233 | trend pre, treat - trend pre, control | = 0 0.281 0.941 0.000 0.764 | trend pre, treat - trend pre, control | = 0.2 sd y 0.059 0.897 0.011 0.038 | trend pre, treat - trend pre, control | = 0.4 sd y 0.007 0.829 0.950 0.000 30 day mortality, AMI Overall 0.138 0.900 0.193 0.233 | trend pre, treat - trend pre, control | = 0 0.212 0.943 0.590 0.581 | trend pre, treat - trend pre, control | = 0.2 sd y 0.128 0.895 0.079 0.134 | trend pre, treat - trend pre, control | = 0.4 sd y 0.070 0.815 0.005 0.017 30 day mortality, heart failure Overall 0.155 0.889 0.164 0.221 | trend pre, treat - trend pre, control | = 0 0.218 0.946 0.546 0.674 | trend pre, treat - trend pre, control | = 0.2 sd y 0.141 0.874 0.050 0.072
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