None Mortality: None Morphological similar to OECD guidelines (3) findings: Test method: > 2 000 mg/kg LD50: the notified chemical was of low toxicity Result: when administered orally in a limit test in rats 9.1.2 Dermal Toxicity (4) rat/SPF bred Species/strain: 5/sex Number/sex of animals: 14 days Observation period: a dose of 2 000 mg/kg was applied in 0.5% (w/v) Method of administration: carboxymethylcelulose and 0.1% (w/v) aqueous polysorbate 80 to an intact skin site; the site was covered with a semi-occlusive dressing; 24 hours the dressing and residual test material were removed there were no signs of systemic toxicity Clinical observations: None Mortality: None Morphological findings: similar to OECD guidelines (3) Test method: > 2 000 mg/kg LD50: the notified chemical was of low acute toxicity Result: when administered dermally to rats in a limit test 9.1.3 Inhalation Toxicity Not performed. This is acceptable since the particle size of the notified chemical is greater than 560 m.
Mortality: Morphological findings: Test method: LD50: None None similar to OECD guidelines (3) > 2 000 mg/kg Result: the notified chemical was of low toxicity when administered orally in a limit test in rats 9.1.2 Dermal Toxicity (4) Species/strain: rat/SPF bred Number/sex of animals: 5/sex Observation period: 14 days Method of administration: a dose of 2 000 mg/kg was applied in 0.5% (w/v) carboxymethylcelulose and 0.1% (w/v) aqueous polysorbate 80 to an intact skin site; the site was covered with a semi-occlusive dressing; 24 hours the dressing and residual test material were removed Clinical observations: there were no signs of systemic toxicity Mortality: None Morphological findings: None Test method: similar to OECD guidelines (3) LD50: > 2 000 mg/kg Result: the notified chemical was of low acute toxicity when administered dermally to rats in a limit test 9.1.3 Inhalation Toxicity Not performed. This is acceptable since the particle size of the notified chemical is greater than 560 m.
NA583FR.docx