Dermal Toxicity (Driscoll, 1998b) rat/Sprague-Dawley CD Species/strain: five/sex Number/sex of animals: 14 days Observation period: single, 24-hour semi-occluded, dermal application to intact Method of administration: skin (shorn flank) at a dose level of 2000 mg/kg bodyweight according to OECD TG 402 Test method: no signs of systemic toxicity observed; signs of dermal Clinical observations: irritation, including slight to moderate erythema, desquamation, leathering and fissuring no deaths observed during the study Mortality: no abnormalities observed Morphological findings: > 2000 mg/kg LD50: the notified chemical was of low dermal toxicity in rats Result: Skin Irritation (Driscoll, 1998c) rabbit/New Zealand White Species/strain: 6 males Number/sex of animals: 72 for determination of Primary Irritation Index Observation period: 14 days for determination of reversibility of changes single four hour, semi-occluded application (0.5mL of Method of administration: notified chemical, pH 5.5) to intact skin of shorn dorsal flank OECD TG 404 Test method:
Dermal Toxicity (Driscoll, 1998b) Species/strain: rat/Sprague-Dawley CD Number/sex of animals: five/sex Observation period: 14 days Method of administration: single, 24-hour semi-occluded, dermal application to intact skin (shorn flank) at a dose level of 2000 mg/kg bodyweight Test method: according to OECD TG 402 Clinical observations: no signs of systemic toxicity observed; signs of dermal irritation, including slight to moderate erythema, desquamation, leathering and fissuring Mortality: no deaths observed during the study Morphological findings: no abnormalities observed LD50: > 2000 mg/kg Result: the notified chemical was of low dermal toxicity in rats Skin Irritation (Driscoll, 1998c) Species/strain: rabbit/New Zealand White Number/sex of animals: 6 males Observation period: 72 for determination of Primary Irritation Index 14 days for determination of reversibility of changes Method of administration: single four hour, semi-occluded application (0.5mL of notified chemical, pH 5.5) to intact skin of shorn dorsal flank Test method: OECD TG 404
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