Eye Irritation 9.1.4.1 NT-6 (Allen, 1995d) rabbit/New Zealand White Species/strain: 3 females Number/sex of animals: 72 hours Observation period: 0.1 mL (vehicle unspecified) of the notified Method of administration: chemical was placed into the conjunctival sac of the right eye of each animal according to OECD TG 405 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992) no corneal or iridal effects were seen; slight Result: conjunctival redness was seen at 1 and 24 hours in 2 animals and at 1 hour in the third animal; slight chemosis was seen in 1 animal 1 hour post- instillation and slight discharge in another animal at the same time point the notified chemical was a slight eye irritant in rabbits Toner containing NT-6 (#1015) (Allen, 1996c) rabbit/New Zealand White Species/strain: 2 males, 1 female Number/sex of animals: 72 hours Observation period: 0.1 mL (vehicle unspecified) of the notified Method of administration: chemical was placed into the conjunctival sac of the right eye of each animal according to OECD TG 405 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992)
Eye Irritation 9.1.4.1 NT-6 (Allen, 1995d) Species/strain: rabbit/New Zealand White Number/sex of animals: 3 females Observation period: 72 hours Method of administration: 0.1 mL (vehicle unspecified) of the notified chemical was placed into the conjunctival sac of the right eye of each animal Test method: according to OECD TG 405 (Organisation for Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992) Result: no corneal or iridal effects were seen; slight conjunctival redness was seen at 1 and 24 hours in 2 animals and at 1 hour in the third animal; slight chemosis was seen in 1 animal 1 hour post- instillation and slight discharge in another animal at the same time point the notified chemical was a slight eye irritant in rabbits Toner containing NT-6 (#1015) (Allen, 1996c) Species/strain: rabbit/New Zealand White Number/sex of animals: 2 males, 1 female Observation period: 72 hours Method of administration: 0.1 mL (vehicle unspecified) of the notified chemical was placed into the conjunctival sac of the right eye of each animal Test method: according to OECD TG 405 (Organisation for Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992)
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