Dermal Toxicity SP-237 (Gabriel, 1980b) rabbit/New Zealand Species/strain: 2/sex Number/sex of animals: 14 days Observation period: test material was placed on a gauze patch and secured under Method of administration: an occlusive wrap for 24 hours 4000, 8000, 16000 and 20000 mg/kg Dose: similar to OECD TG 402 Test method: no deaths occurred during the study Mortality: no unusual behavioural signs were Clinical observations: noted gross abnormalities were observed Morphological > 20000 mg/kg LD50: SP-237 was of low dermal toxicity in rats Result: Inhalation Toxicity SP-237 (Gabriel, 1980c) rat/not stated Species/strain: 5/sex Number/sex of animals: 14 days Observation period: aerosol, 15.5 mg/L (maximum attainable concentration) Dose Range: whole body, 1 hour exposure, dynamically operated Method of administration: chamber limit test, similar to OECD TG 403 Test method: no unusual behavioural signs were noted Clinical observations: no deaths were recorded during the observation period Mortality:
Dermal Toxicity SP-237 (Gabriel, 1980b) Species/strain: rabbit/New Zealand Number/sex of animals: 2/sex Observation period: 14 days Method of administration: test material was placed on a gauze patch and secured under an occlusive wrap for 24 hours Dose: 4000, 8000, 16000 and 20000 mg/kg Test method: similar to OECD TG 402 Mortality: no deaths occurred during the study Clinical observations: no unusual behavioural signs were noted Morphological gross abnormalities were observed LD50: > 20000 mg/kg Result: SP-237 was of low dermal toxicity in rats Inhalation Toxicity SP-237 (Gabriel, 1980c) Species/strain: rat/not stated Number/sex of animals: 5/sex Observation period: 14 days Dose Range: aerosol, 15.5 mg/L (maximum attainable concentration) Method of administration: whole body, 1 hour exposure, dynamically operated chamber Test method: limit test, similar to OECD TG 403 Clinical observations: no unusual behavioural signs were noted Mortality: no deaths were recorded during the observation period
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