salivation was observed in two males and one female and waddling/unsteady gait was observed in one male and all females. One female was observed walking on toes and one female showed increased sensitivity to touch. Recovery as judged by external appearance and behaviour was complete in all animals by day 5. No abnormalities were observed during macroscopic Morphological findings: examinations. > 2000mg/kg LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Mason, 1999b) Rat, Sprague Dawley Species/strain: 5 males, 5 females Number/sex of animals: 14 days Observation period: 24 hour application to shaved skin via 50 x 50 cm porous Method of administration: gauze pad covered with waterproof dressing. OECD TG 402 Test method: None Mortality: No mortalities occurred and all animals gained weight Clinical observations: throughout the study. Vocalisation and hyperactivity were observed in one female on day 1. Slight to well-defined dermal irritation resolving by day 9 was seen in four males and three females. Additional desquamation was observed in two females with localised spots and/or scabbing in one female. These were resolved by day 13. No abnormalities were observed during macroscopic Morphological findings: examinations. Draize scores:
salivation was observed in two males and one female and waddling/unsteady gait was observed in one male and all females. One female was observed walking on toes and one female showed increased sensitivity to touch. Recovery as judged by external appearance and behaviour was complete in all animals by day 5. Morphological findings: No abnormalities were observed during macroscopic examinations. LD50: > 2000mg/kg Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Mason, 1999b) Species/strain: Rat, Sprague Dawley Number/sex of animals: 5 males, 5 females Observation period: 14 days Method of administration: 24 hour application to shaved skin via 50 x 50 cm porous gauze pad covered with waterproof dressing. Test method: OECD TG 402 Mortality: None Clinical observations: No mortalities occurred and all animals gained weight throughout the study. Vocalisation and hyperactivity were observed in one female on day 1. Slight to well-defined dermal irritation resolving by day 9 was seen in four males and three females. Additional desquamation was observed in two females with localised spots and/or scabbing in one female. These were resolved by day 13. Morphological findings: No abnormalities were observed during macroscopic examinations. Draize scores:
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