Not stated Test method: Nil Mortality: There were no clinical signs of systemic toxicity. Clinical observations: Moderate hydrometra was observed in one female. Clear, firm Morphological findings: raised areas on all lobes of the lung were in one male. No other abnormalities were noted at necropsy. > 4 168 mg/kg Estimated LD50: Oronite Gulf Synfluid 8cSt was of very low acute oral toxicity Result: to the rat. 9.1.2.1 Dermal Toxicity (Safepharm Laboratories Limited 1995b) Alkane 5 Test Substance: Rat/Sprague-Dawley CD Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A single, 24-hour semi occluded dermal application to intact Method of administration: skin at a dose of 2 000 mg/kg bw, dose volume of 2.43 mL/kg. OECD TG 402; EC Method B3. Test method: Nil Mortality: No clinical signs of systemic toxicity were noted. Clinical observations: No signs of dermal irritation were noted. Dermal response: No abnormalities were noted at necropsy. Morphological findings: > 2 000 mg/kg bw LD50: Alkane 5 was of low dermal toxicity to the rat. Result: 9.1.2.2 Dermal Toxicity (Hazelton Raltech Inc 1982a) Gulf Synfluid 8cSt Test Substance: Rabbit/New Zealand White Species/strain:
Test method: Not stated Mortality: Nil Clinical observations: There were no clinical signs of systemic toxicity. Morphological findings: Moderate hydrometra was observed in one female. Clear, firm raised areas on all lobes of the lung were in one male. No other abnormalities were noted at necropsy. Estimated LD50: > 4 168 mg/kg Result: Oronite Gulf Synfluid 8cSt was of very low acute oral toxicity to the rat. 9.1.2.1 Dermal Toxicity (Safepharm Laboratories Limited 1995b) Test Substance: Alkane 5 Species/strain: Rat/Sprague-Dawley CD Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A single, 24-hour semi occluded dermal application to intact skin at a dose of 2 000 mg/kg bw, dose volume of 2.43 mL/kg. Test method: OECD TG 402; EC Method B3. Mortality: Nil Clinical observations: No clinical signs of systemic toxicity were noted. Dermal response: No signs of dermal irritation were noted. Morphological findings: No abnormalities were noted at necropsy. LD50: > 2 000 mg/kg bw Result: Alkane 5 was of low dermal toxicity to the rat. 9.1.2.2 Dermal Toxicity (Hazelton Raltech Inc 1982a) Test Substance: Gulf Synfluid 8cSt Species/strain: Rabbit/New Zealand White
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