Acute Dermal LD50 > 2 000 mg/kg > 2 000 mg/kg Skin Irritation Slight to moderate irritant Slight to moderate irritant Eye Irritation Slight irritant Slight irritant Skin Sensitisation Non sensitising Non sensitising 90-day Repeat Dose Toxicity NOAEL: 1 000 mg/kg; Not tested NOEL: 50 mg/kg/day males, 1 000 mg/kg/day females. Genotoxicity: Ames test Non mutagenic Non mutagenic Chromosome aberration, Non clastogenic Not tested in vitro Mouse micronucleus test, Non genotoxic Not tested in vivo 9.1.1.1 Oral Toxicity (Safepharm Laboratories Limited, 1998d) SDP Test substance: Rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period: Gavage, 5 000 mg/kg (dose volume of 5.90 mL/kg) Method of administration: OECD TG 401 Test method: No signs of systemic toxicity Clinical observations: Nil Mortality: No abnormalities detected Morphological findings: > 5 000 mg/kg LD50: SDP was of very low oral toxicity in rats Result: 9.1.1.2 Oral Toxicity (Safepharm Laboratories Limited, 1998q) SOP Test substance: Rat/Sprague Dawley Species/strain: 5/sex Number/sex of animals: 14 days Observation period:
Acute Dermal LD50 > 2 000 mg/kg > 2 000 mg/kg Skin Irritation Slight to moderate irritant Slight to moderate irritant Eye Irritation Slight irritant Slight irritant Skin Sensitisation Non sensitising Non sensitising 90-day Repeat Dose Toxicity NOAEL: 1 000 mg/kg; NOEL: 50 mg/kg/day males, 1 000 mg/kg/day females. Not tested Genotoxicity: Ames test Chromosome aberration, in vitro Mouse micronucleus test, in vivo Non mutagenic Non clastogenic Non genotoxic Non mutagenic Not tested Not tested 9.1.1.1 Oral Toxicity (Safepharm Laboratories Limited, 1998d) Test substance: SDP Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Gavage, 5 000 mg/kg (dose volume of 5.90 mL/kg) Test method: OECD TG 401 Clinical observations: No signs of systemic toxicity Mortality: Nil Morphological findings: No abnormalities detected LD50: > 5 000 mg/kg Result: SDP was of very low oral toxicity in rats 9.1.1.2 Oral Toxicity (Safepharm Laboratories Limited, 1998q) Test substance: SOP Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days
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