Figure legends Figure 1. Inflammasomes signalling in different cell types involved in brain inflammation and injury. Due to the extensive literature data available, inflammasome signaling in monocytes and macrophages is not discussed in detail only pathways confirmed in the case of microglia. See detailed explanation in the text. Please note that triggers, pathways and downstream events of inflammasome activation were depicted in the figure only if experimental evidence is available for the given cell type. Tables Inflammasome Comorbidity Trigger activated hyperglycemia, ATP, HMGB1, Type 2 diabetes NLRP3, FFAs, IAPP, MSU, SFAs Atherosclerosis NLRP3, cholesterol crystals NLRP3 cholesterol crystals Hyperlipidemia and Obesity #NLRP1 ceramide
Figure legends Figure 1. Inflammasomes signalling in different cell types involved in brain inflammation and injury. Due to the extensive literature data available, inflammasome signaling in monocytes and macrophages is not discussed in detail only pathways confirmed in the case of microglia. See detailed explanation in the text. Please note that triggers, pathways and downstream events of inflammasome activation were depicted in the figure only if experimental evidence is available for the given cell type. Tables Comorbidity Inflammasome activated Trigger Type 2 diabetes NLRP3, hyperglycemia, ATP, HMGB1, FFAs, IAPP, MSU, SFAs Atherosclerosis NLRP3, cholesterol crystals Hyperlipidemia and Obesity NLRP3 #NLRP1 cholesterol crystals ceramide