TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity oral 17 – B.2. Acute toxicity dermal 17 – B.3. Acute toxicity inhalation 18 – B.4. Irritation skin (in vitro) 19 – B.5. Irritation skin (in vitro) 20 – B.6. Irritation eye (in vitro) 20 – B.7. Irritation eye 21 – B.8. Skin sensitisation 22 B.9. Repeat dose toxicity 23 B.10. Genotoxicity bacteria 25 – B.11. Genotoxicity in vitro 26 – Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 30 BIBLIOGRAPHY 32
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity – oral 17 B.2. Acute toxicity – dermal 17 B.3. Acute toxicity – inhalation 18 B.4. Irritation – skin (in vitro) 19 B.5. Irritation – skin (in vitro) 20 B.6. Irritation – eye (in vitro) 20 B.7. Irritation – eye 21 B.8. Skin sensitisation 22 B.9. Repeat dose toxicity 23 B.10. Genotoxicity – bacteria 25 B.11. Genotoxicity – in vitro 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 30 BIBLIOGRAPHY 32