TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity oral 17 – B.2. Irritation skin 17 – B.3. Irritation eye (in 18 vitro) – B.4. Skin sensitisation human volunteers 18 – B.5. Repeat dose toxicity 19 B.6. Genotoxicity bacteria 20 – B.7. Genotoxicity 21 in vitro – B.8. Reproduction/Developmental toxicity 22 Appendix C: Environmental Fate and Ecotoxicological Investigations 24 C.1. Environmental Fate 24 C.1.1. Ready biodegradability 24 C.2. Ecotoxicological Investigations 24 C.2.1. Acute toxicity to fish 24 C.2.2. Acute toxicity to aquatic invertebrates 25 C.2.3. Algal growth inhibition test 26 BIBLIOGRAPHY 28
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity – oral 17 B.2. Irritation – skin 17 B.3. Irritation – eye (in vitro) 18 B.4. Skin sensitisation – human volunteers 18 B.5. Repeat dose toxicity 19 B.6. Genotoxicity – bacteria 20 B.7. Genotoxicity – in vitro 21 B.8. Reproduction/Developmental toxicity 22 Appendix C: Environmental Fate and Ecotoxicological Investigations 24 C.1. Environmental Fate 24 C.1.1. Ready biodegradability 24 C.2. Ecotoxicological Investigations 24 C.2.1. Acute toxicity to fish 24 C.2.2. Acute toxicity to aquatic invertebrates 25 C.2.3. Algal growth inhibition test 26 BIBLIOGRAPHY 28