ANSWER KEY and RUBRICS: Key Features Possible Explanation Nanoparticles - SPIO must be used to - Detected through tumor function with MRI due to markers Base Particle: SPIO its magnetic properties Cancer - Must detect small Accessory Particles: - Herceptin must be added concentrations of APTES, Herceptin to bind to tumor markers Detection compounds Possible inclusions: -APTES is a linker that - Use MRI for detection Raman detector, PEG, allows other molecules to Calcein Probe bind to nanoparticles - Lisosome particles are ideal because of their ability to cross biological barriers and formation of vesicles - Attacks nervous system Base Particle: Lisosome - APTES = linker Multiple - Treatment must cross Sclerosis Blood Brain Barrier (BBB) Other Possible - Prednisolone, the MS Particles: medication, should be Silica, Chitosan enclosed within the Accessory Particles: APTES, Prednisolone, - PEG allows the PEG molecule to cross the BBB - Causes inflation of airway tissue and production of Base Particle: - Chitosan interacts with mucus Chitosan Interferon, an important Asthma factor in Asthma - Results from low levels Accessory Particles: of Interferon-gamma None required, but - Attaches to Mucus -Altered gene expression is could add APTES and a potential therapy PEG - Nanopolymer is ideal for Base Particle: its positively charged - Microbes develop rapidly Nanopolymer surface to combat chemical Antimicrobial antibiotics Accessory Particles: - Additional molecules None Required, but could either be to mask Resistance - Microbes have negative could add APTES, the positive charge until membranes PEG, Raman necessary or for detection Reporters or Calcein purposes AM
ANSWER KEY and RUBRICS: Key Features Possible Nanoparticles Explanation Cancer Detection - Detected through tumor markers - Must detect small concentrations of compounds - Use MRI for detection Base Particle: SPIO Accessory Particles: APTES, Herceptin Possible inclusions: Raman detector, PEG, Calcein Probe - SPIO must be used to function with MRI due to its magnetic properties - Herceptin must be added to bind to tumor markers -APTES is a linker that allows other molecules to bind to nanoparticles Multiple Sclerosis - Attacks nervous system - Treatment must cross Blood Brain Barrier (BBB) Base Particle: Lisosome Other Possible Particles: Silica, Chitosan Accessory Particles: APTES, Prednisolone, PEG - Lisosome particles are ideal because of their ability to cross biological barriers and formation of vesicles - APTES = linker - Prednisolone, the MS medication, should be enclosed within the - PEG allows the molecule to cross the BBB Asthma - Causes inflation of airway tissue and production of mucus - Results from low levels of Interferon-gamma -Altered gene expression is a potential therapy Base Particle: Chitosan Accessory Particles: None required, but could add APTES and PEG - Chitosan interacts with Interferon, an important factor in Asthma - Attaches to Mucus Antimicrobial Resistance - Microbes develop rapidly to combat chemical antibiotics - Microbes have negative membranes Base Particle: Nanopolymer Accessory Particles: None Required, but could add APTES, PEG, Raman Reporters or Calcein AM - Nanopolymer is ideal for its positively charged surface - Additional molecules could either be to mask the positive charge until necessary or for detection purposes