Hypertension NLRP3 hypoxia, high salt levels, , Gout and Arthritis NLRP3, NLRC4 MSU, CPPD crystals Table 1. Inflammasomes in vascular diseases and risk factors for brain disease. Inflammasomes involved in different conditions and triggers identified were listed. See explanation in the text. #Inflammasome activation is associated with a protective phynotype. Inflammasome CNS disorder Trigger activated Cerebral aneurysms and intracerebral /subarachnoid NLRP3, ROS, haemorrhage NLRP3, drop in extracellular pH NLRP1, decrease in cytosolic ATP Ischemic brain injury NLRC4 intracellular K+ efflux, AIM2 Pannexin 1 NLRP1, , , Traumatic brain injury NLRP3
Hypertension NLRP3 hypoxia, high salt levels, , Gout and Arthritis NLRP3, NLRC4 MSU, CPPD crystals Table 1. Inflammasomes in vascular diseases and risk factors for brain disease. Inflammasomes involved in different conditions and triggers identified were listed. See explanation in the text. #Inflammasome activation is associated with a protective phynotype. CNS disorder Inflammasome activated Trigger Cerebral aneurysms and intracerebral /subarachnoid haemorrhage NLRP3, ROS, Ischemic brain injury NLRP3, NLRP1, NLRC4 AIM2 drop in extracellular pH decrease in cytosolic ATP intracellular K+ efflux, Pannexin 1 Traumatic brain injury NLRP1, , , NLRP3