Authors’ conclusion: findings provide strong evidence that 12-weeks of moderate-intensity aerobic exercise does not alleviate VMS but “These may result in small improvements in sleep quality, insomnia and depression in midlife, sedentary women.” Newton et al (2014)17, physical interventions (yoga) MsFLASH 02 - Menopausal Yoga (12 weekly Usual activity Vasomotor Hot flashes / day at (1) Yes** Efficacy of Yoga women, including: 90-minute classes) symptoms 12 from (2) Yes** for Vasomotor frequency and baseline, mean (3) Yes** Women with a Symptoms: A bother (4) Yes** (95% CI) uterus who have Randomized (5) Yes** skipped 2 or more Controlled Yoga: (−3.6, EB risk of bias: −2.9 menstrual cycles Low −2.2) with an N = 249 Usual activity: −2.6 amenorrhea Age = 40-62 years (−3.2, −2.0) interval days in ≥60 Duration = 12 Difference: −0.3 the past 12 weeks (−1.2, 0.6) months. Follow-up = at 8 or p= 0.119 who have had 12 weeks a bi-lateral VMS bother at 12 oophorectomy weeks from (surgical removal baseline, mean of both ovaries). (95% CI) without a Yoga: (−0.7, −0.6 uterus who still −0.4) have ovaries, Usual activity: −0.5 under certain (−0.6, −0.4) conditions Difference: 0.0 determined during (−0.2, screening p= 0.417 Authors’ conclusion: healthy women, 12 weeks of yoga class plus home practice compared with usual activity did not improve VMS “Among frequency or bother, but reduced insomnia symptoms.” Joffe et al (2014)26, (low-dose estradiol) pharmacologic interventions MsFLASH 03 - Peri- and Low-dose oral Placebo Mean VMS Frequency - (1) Yes** Randomized postmenopausal frequency of Mean (95% CI) (2) Yes**
Authors’ conclusion: “These findings provide strong evidence that 12-weeks of moderate-intensity aerobic exercise does not alleviate VMS but may result in small improvements in sleep quality, insomnia and depression in midlife, sedentary women.” Newton et al (2014)17, physical interventions (yoga) MsFLASH 02 - Efficacy of Yoga for Vasomotor Symptoms: A Randomized Controlled N = 249 Age = 40-62 years Duration = 12 weeks Follow-up = at 8 or 12 weeks Menopausal women, including: Women with a uterus who have skipped 2 or more menstrual cycles with an amenorrhea interval ≥60 days in the past 12 months. who have had a bi-lateral oophorectomy (surgical removal of both ovaries). without a uterus who still have ovaries, under certain conditions determined during screening Yoga (12 weekly 90-minute classes) Usual activity Vasomotor symptoms frequency and bother Hot flashes / day at 12 from baseline, mean (95% CI) Yoga: −2.9 (−3.6, −2.2) Usual activity: −2.6 (−3.2, −2.0) Difference: −0.3 (−1.2, 0.6) p= 0.119 VMS bother at 12 weeks from baseline, mean (95% CI) Yoga: −0.6 (−0.7, −0.4) Usual activity: −0.5 (−0.6, −0.4) Difference: 0.0 (−0.2, p= 0.417 (1) Yes** (2) Yes** (3) Yes** (4) Yes** (5) Yes** EB risk of bias: Low Authors’ conclusion: “Among healthy women, 12 weeks of yoga class plus home practice compared with usual activity did not improve VMS frequency or bother, but reduced insomnia symptoms.” Joffe et al (2014)26, pharmacologic interventions (low-dose estradiol) MsFLASH 03 - Randomized Peri- and postmenopausal Low-dose oral Placebo Mean frequency of VMS Frequency - Mean (95% CI) (1) Yes** (2) Yes**