TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 13 7.1. Environmental Exposure & Fate Assessment 13 7.1.1. Environmental Exposure 13 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 14 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 15 Appendix A: Physical and Chemical Properties 16 Appendix B: Toxicological Investigations 18 B.1. Acute toxicity oral 18 – B.2. Acute toxicity dermal 18 – B.3. Acute toxicity inhalation 19 – B.4. Irritation skin 20 – B.5. Irritation eye 20 – B.6. Skin sensitisation mouse local lymph node assay (LLNA) 21 – B.7. Repeat dose toxicity 22 B.8. Genotoxicity bacteria 24 – B.9. Genotoxicity in vitro 25 – B.10. Genotoxicity in vivo 26 – Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute toxicity to fish 29 C.2.3. Acute toxicity to aquatic invertebrates 29 C.2.4. Algal growth inhibition test 30 BIBLIOGRAPHY 32
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 10 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 13 7.1. Environmental Exposure & Fate Assessment 13 7.1.1. Environmental Exposure 13 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 14 7.2. Environmental Effects Assessment 14 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 15 Appendix A: Physical and Chemical Properties 16 Appendix B: Toxicological Investigations 18 B.1. Acute toxicity – oral 18 B.2. Acute toxicity – dermal 18 B.3. Acute toxicity – inhalation 19 B.4. Irritation – skin 20 B.5. Irritation – eye 20 B.6. Skin sensitisation – mouse local lymph node assay (LLNA) 21 B.7. Repeat dose toxicity 22 B.8. Genotoxicity – bacteria 24 B.9. Genotoxicity – in vitro 25 B.10. Genotoxicity – in vivo 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.2. Ecotoxicological Investigations 28 C.2.1. Acute toxicity to fish 28 C.2.2. Acute toxicity to fish 29 C.2.3. Acute toxicity to aquatic invertebrates 29 C.2.4. Algal growth inhibition test 30 BIBLIOGRAPHY 32