TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 8 6.2. Human Health Effects Assessment 8 6.3. Human Health Risk Characterisation 9 6.3.1. Occupational Health and Safety 9 6.3.2. Public Health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1. Environmental Exposure 9 7.1.2. Environmental Fate 10 7.1.3. Predicted Environmental Concentration (PEC) 10 7.2. Environmental Effects Assessment 11 7.2.1. Predicted No-Effect Concentration 11 7.3. Environmental Risk Assessment 11 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 13 B.1. Acute toxicity oral 13 – B.2. Acute toxicity dermal 13 – B.3. Irritation skin 13 – B.4. Irritation eye 14 – B.5. Skin sensitisation 14 B.6. Repeat dose toxicity 15 B.7. Genotoxicity bacteria 17 – B.8. Genotoxicity in vitro 17 – B.9. Genotoxicity in vitro 18 – Appendix C: Environmental Fate and Ecotoxicological Investigations 20 C.1. Environmental Fate 20 C.1.1. Ready biodegradability 20 C.2. Ecotoxicological Investigations 20 C.2.1. Acute toxicity to fish 20 C.2.2. Acute toxicity to aquatic invertebrates 21 C.2.3. Algal growth inhibition test 21 C.2.4. Inhibition of microbial activity 22 BIBLIOGRAPHY 23
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 8 6.2. Human Health Effects Assessment 8 6.3. Human Health Risk Characterisation 9 6.3.1. Occupational Health and Safety 9 6.3.2. Public Health 9 7. ENVIRONMENTAL IMPLICATIONS 9 7.1. Environmental Exposure & Fate Assessment 9 7.1.1. Environmental Exposure 9 7.1.2. Environmental Fate 10 7.1.3. Predicted Environmental Concentration (PEC) 10 7.2. Environmental Effects Assessment 11 7.2.1. Predicted No-Effect Concentration 11 7.3. Environmental Risk Assessment 11 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 13 B.1. Acute toxicity – oral 13 B.2. Acute toxicity – dermal 13 B.3. Irritation – skin 13 B.4. Irritation – eye 14 B.5. Skin sensitisation 14 B.6. Repeat dose toxicity 15 B.7. Genotoxicity – bacteria 17 B.8. Genotoxicity – in vitro 17 B.9. Genotoxicity – in vitro 18 Appendix C: Environmental Fate and Ecotoxicological Investigations 20 C.1. Environmental Fate 20 C.1.1. Ready biodegradability 20 C.2. Ecotoxicological Investigations 20 C.2.1. Acute toxicity to fish 20 C.2.2. Acute toxicity to aquatic invertebrates 21 C.2.3. Algal growth inhibition test 21 C.2.4. Inhibition of microbial activity 22 BIBLIOGRAPHY 23