TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 7 6.2. Human Health Effects Assessment 7 6.3. Human Health Risk Characterisation 8 6.3.1. Occupational Health and Safety 8 6.3.2. Public Health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1. Environmental Exposure 8 7.1.2. Environmental Fate 9 7.1.3. Predicted Environmental Concentration (PEC) 9 7.2. Environmental Effects Assessment 9 7.2.1. Predicted No-Effect Concentration 9 7.3. Environmental Risk Assessment 9 Appendix A: Toxicological Investigations 10 A.1. Repeat dose toxicity 10 A.2. Genotoxicity bacteria 11 – A.3. Genotoxicity in vitro 12 – Appendix B: Environmental Fate and Ecotoxicological Investigations 13 B.1. Environmental Fate 13 B.1.1. Ready biodegradability 13 B.1.2. Bioaccumulation 13 B.2. Ecotoxicological Investigations 14 B.2.1. Acute toxicity to fish 14 BIBLIOGRAPHY 15 SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT APPLICANT CHEMICAL NAME HAZARDOUS INTRODUCTION USE REFERENCE VOLUME LTD/1979 Admil Cyclotetrasiloxane, ND* Component of liquid ≤ 0.4 tonnes per Adhesives Pty 2,4,6,8-tetramethyl-, annum silicone rubber Ltd reaction products with *ND = not determined CONCLUSIONS AND REGULATORY OBLIGATIONS
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 7 6.2. Human Health Effects Assessment 7 6.3. Human Health Risk Characterisation 8 6.3.1. Occupational Health and Safety 8 6.3.2. Public Health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1. Environmental Exposure 8 7.1.2. Environmental Fate 9 7.1.3. Predicted Environmental Concentration (PEC) 9 7.2. Environmental Effects Assessment 9 7.2.1. Predicted No-Effect Concentration 9 7.3. Environmental Risk Assessment 9 Appendix A: Toxicological Investigations 10 A.1. Repeat dose toxicity 10 A.2. Genotoxicity – bacteria 11 A.3. Genotoxicity – in vitro 12 Appendix B: Environmental Fate and Ecotoxicological Investigations 13 B.1. Environmental Fate 13 B.1.1. Ready biodegradability 13 B.1.2. Bioaccumulation 13 B.2. Ecotoxicological Investigations 14 B.2.1. Acute toxicity to fish 14 BIBLIOGRAPHY 15 SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT CHEMICAL NAME HAZARDOUS INTRODUCTION VOLUME USE LTD/1979 Admil Adhesives Pty Ltd Cyclotetrasiloxane, 2,4,6,8-tetramethyl-, reaction products with ND* ≤ 0.4 tonnes per annum Component of liquid silicone rubber *ND = not determined CONCLUSIONS AND REGULATORY OBLIGATIONS