TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 11 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity oral 17 – B.2. Acute toxicity dermal 17 – B.3. Acute toxicity inhalation 18 – B.4. Irritation skin (in 18 vitro) – B.5. Irritation skin (in 19 vitro) – B.6. Irritation eye 20 – B.7. Skin sensitisation 20 B.8. Repeat dose toxicity 21 B.9. Genotoxicity bacteria 22 – B.10. Genotoxicity 23 in vitro – Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.2. Ecotoxicological Investigations 25 C.2.1. Acute toxicity to fish 25 C.2.2. Acute toxicity to aquatic invertebrates 26 C.2.3. Algal growth inhibition test 27 C.2.4. Inhibition of microbial activity 27 BIBLIOGRAPHY 29
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 11 6.3. Human Health Risk Characterisation 12 6.3.1. Occupational Health and Safety 12 6.3.2. Public Health 12 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 13 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity – oral 17 B.2. Acute toxicity – dermal 17 B.3. Acute toxicity – inhalation 18 B.4. Irritation – skin (in vitro) 18 B.5. Irritation – skin (in vitro) 19 B.6. Irritation – eye 20 B.7. Skin sensitisation 20 B.8. Repeat dose toxicity 21 B.9. Genotoxicity – bacteria 22 B.10. Genotoxicity – in vitro 23 Appendix C: Environmental Fate and Ecotoxicological Investigations 25 C.1. Environmental Fate 25 C.1.1. Ready biodegradability 25 C.2. Ecotoxicological Investigations 25 C.2.1. Acute toxicity to fish 25 C.2.2. Acute toxicity to aquatic invertebrates 26 C.2.3. Algal growth inhibition test 27 C.2.4. Inhibition of microbial activity 27 BIBLIOGRAPHY 29