Mevinphos A dietary exposure assessment was not required for mevinphos as the request was for a reduction in the existing commodity MRL. An All other foods except animal food commodities MRL for mevinphos is not under consideration at this point in time. Naled A dietary exposure assessment was not required for naled as the request was for the deletion of the chemical from Schedule 20. An All other foods except animal food commodities MRL for naled is not under consideration at this point in time. Oxadixyl An All other foods except animal food commodities MRL of 0.1 mg/kg is proposed based on the following considerations: Considerations Comments Limit of determination (LOD) 0.01 Lowest plant commodity MRL 0.5 mg/kg Magnitude of existing plant commodity The range of existing MRLs is 0.5 mg/kg (Fruiting MRLs vegetables, Cucurbits; Onion, bulb) to 5 mg/kg (Leafy vegetables). Lowest plant commodity MRL that is 0.5 mg/kg not the LOD Most relevant reference point to 0.5 mg/kg minimise off-label use Consumption amount used in NEDI 43.45 g/kg bw/day calculation for All other foods except animal commodities Chronic dietary exposure (NEDI) 45% of the ADI considering existing permissions only Proposed All other foods except animal 0.1 mg/kg commodities MRL1 NEDI including All other foods except 50% of the ADI animal commodities MRL and existing permissions Percentage contribution of All other Although An All other foods except animal commodities foods except animal commodities to MRL of 0.2 could have been established as at this limit it total chronic dietary exposure contributed <20% to total dietary exposure, this limit was not considered practical. An All other foods except animal commodities MRL of 0.1 mg/kg represents a contribution of 8% to total dietary exposure which is within the 20% target and is considered acceptable. Acute dietary exposure assessment An acute dietary exposure assessment is considered (NESTI) unnecessary for oxadixyl because the APVMA and JMPR consider an ARfD unnecessary. Conclusion After considering the principles established and agreed in FSANZ proposal P1027, an All other foods except animal commodities MRL of 0.1 mg/kg is acceptable because it has been shown to be practical, adequately manages the risk of off-label use and does not increase the level of concern about the risk to public health.
Mevinphos A dietary exposure assessment was not required for mevinphos as the request was for a reduction in the existing commodity MRL. An All other foods except animal food commodities MRL for mevinphos is not under consideration at this point in time. Naled A dietary exposure assessment was not required for naled as the request was for the deletion of the chemical from Schedule 20. An All other foods except animal food commodities MRL for naled is not under consideration at this point in time. Oxadixyl An All other foods except animal food commodities MRL of 0.1 mg/kg is proposed based on the following considerations: Considerations Comments Limit of determination (LOD) 0.01 Lowest plant commodity MRL 0.5 mg/kg Magnitude of existing plant commodity MRLs The range of existing MRLs is 0.5 mg/kg (Fruiting vegetables, Cucurbits; Onion, bulb) to 5 mg/kg (Leafy vegetables). Lowest plant commodity MRL that is not the LOD 0.5 mg/kg Most relevant reference point to minimise off-label use 0.5 mg/kg Consumption amount used in NEDI calculation for All other foods except animal commodities 43.45 g/kg bw/day Chronic dietary exposure (NEDI) considering existing permissions only 45% of the ADI Proposed All other foods except animal commodities MRL1 0.1 mg/kg NEDI including All other foods except animal commodities MRL and existing permissions 50% of the ADI Percentage contribution of All other foods except animal commodities to total chronic dietary exposure Although An All other foods except animal commodities MRL of 0.2 could have been established as at this limit it contributed <20% to total dietary exposure, this limit was not considered practical. An All other foods except animal commodities MRL of 0.1 mg/kg represents a contribution of 8% to total dietary exposure which is within the 20% target and is considered acceptable. Acute dietary exposure assessment (NESTI) An acute dietary exposure assessment is considered unnecessary for oxadixyl because the APVMA and JMPR consider an ARfD unnecessary. Conclusion After considering the principles established and agreed in FSANZ proposal P1027, an All other foods except animal commodities MRL of 0.1 mg/kg is acceptable because it has been shown to be practical, adequately manages the risk of off-label use and does not increase the level of concern about the risk to public health.