Overall injection Needle stick procedure experience: (1) 1.78 +/- 1.44 1=awful to 5=excellent (2) 1.75 +/- 1.46 (3) 1.48 +/- 1.58 P = 0.38 Burning (1) 1.45 +/- 1.28 (2) 1.58 +/- 1.48 (3) 1.13 +/- 1.36 P = 0.23 Overall satisfaction (1) 4.38 +/- 0.59 (2) 4.58 +/- 0.64 (3) 4.40 +/- 0.63 P = 0.017 Gregori (2012) Inclusion: 4% liquid lidocaine on N = 50 pts Day of: Most common Both techniques were Age > 18 yrs, cotton swabs vs. 3.5% Mean age 74 yrs Discomfort during prep effective; pts had mild AE’s: Prospective, Need for ranibizumab lidocaine gel Male 48% Score gel vs. swab Watery eyes discomfort with both randomized, intravitreal injection, White race 78% 2.09 vs. 2.1; p=0.5 Light sensitivity on same and day single-center trial > 3 prior Same physician, same ARMD 70% Burning/stinging after; slightly more Rec’d injections technician prepped Discomfort w/ needle discomfort during Endpoints: patient Score gel vs. swab needle penetration day and next-day 2.0 vs. 1.7; p=0.026 with gel, although pts pain control, Following injection, preferred gel safety masked staff gave Overall satisfied questionnaire to pt Score gel vs. swab 4.5 vs. 4.3; p=0.4 Within 24 hrs of injection, pts Day after: Discomfort contacted via phone Score gel vs. swab 1.6 vs. 1.8; p=0.063 Overall satisfied Score gel vs. swab 4.3 vs. 4.3; p=0.91
Overall injection procedure experience: 1=awful to 5=excellent Needle stick (1) 1.78 +/- 1.44 (2) 1.75 +/- 1.46 (3) 1.48 +/- 1.58 P = 0.38 Burning (1) 1.45 +/- 1.28 (2) 1.58 +/- 1.48 (3) 1.13 +/- 1.36 P = 0.23 Overall satisfaction (1) 4.38 +/- 0.59 (2) 4.58 +/- 0.64 (3) 4.40 +/- 0.63 P = 0.017 Gregori (2012) Prospective, randomized, single-center trial Endpoints: and next-day pain control, safety Inclusion: Age > 18 yrs, Need for ranibizumab intravitreal injection, Rec’d > 3 prior injections 4% liquid lidocaine on cotton swabs vs. 3.5% lidocaine gel Same physician, same technician prepped patient Following injection, masked staff gave questionnaire to pt Within 24 hrs of injection, pts contacted via phone N = 50 pts Mean age 74 yrs Male 48% White race 78% ARMD 70% Day of: Discomfort during prep Score gel vs. swab 2.09 vs. 2.1; p=0.5 Discomfort w/ needle Score gel vs. swab 2.0 vs. 1.7; p=0.026 Overall satisfied Score gel vs. swab 4.5 vs. 4.3; p=0.4 Day after: Discomfort Score gel vs. swab 1.6 vs. 1.8; p=0.063 Overall satisfied Score gel vs. swab 4.3 vs. 4.3; p=0.91 Most common AE’s: Watery eyes Light sensitivity Burning/stinging Both techniques were effective; pts had mild discomfort with both on same day and day after; slightly more discomfort during needle penetration with gel, although pts preferred gel