Supplementary Table S1. Response criteria for each study Response Study MT103-205 Study MT103-206 Study MT103-211 Complete No evidence of circulating blasts in bone blasts in bone ≤5% ≤5% remission (CR) blasts or extramedullary marrow marrow disease: <5% blasts in bone No evidence of No evidence of marrow (M1 bone marrow) disease disease Subclassifications: Full recovery of Full recovery of peripheral blood peripheral blood full recovery of counts: platelets counts: platelets peripheral blood counts: ANC and platelets >100,000/µl >100,000/μl, >100,000/μl ANC and ANC >1000/µl >1500/μl >1000/μl incomplete recovery of hemoglobin ≥11 g/dl peripheral blood counts: platelets >50,000/µl but ANC ≤100,000/µl; >500/µl but ≤1000/µl Complete - blasts in bone blasts in bone ≤5% ≤5% remission with marrow marrow partial No evidence of No evidence of hematologic disease disease recovery (CRh) Full recovery of Partial recovery of peripheral blood peripheral blood counts: platelets counts: platelets ANC and >50,000/μl, >50,000/μl and ANC >500/μl, >500/μl hemoglobin g/dl ≥7 Blast-free - - blasts in bone ≤5% hypoplastic or marrow aplastic bone No evidence of marrow disease Partial remission Complete disappearance of blasts in bone 6%–25% blasts in ≤25% circulating blasts and marrow bone marrow with a achievement of M2 marrow ≥50% reduction or <25% blast from baseline status (≥5% cells) and appearance of normal progenitor cells Hematological >25% blasts in bone >5% blasts in bone >5% blasts in bone relapse marrow after documented marrow after marrow, or blasts in CR documented peripheral blood An extramedullary relapse CR/CRh after documented was considered a relapse An extramedullary CR/CRh and was subdivided into relapse was An extramedullary CD19-positive and assessed as relapse was hematological assessed as relapse hematological relapse Abbreviations: ANC, absolute neutrophil count.
Supplementary Table S1. Response criteria for each study Response Study MT103-205 Study MT103-206 Study MT103-211 Complete remission (CR) No evidence of circulating blasts or extramedullary disease: <5% blasts in bone marrow (M1 bone marrow) Subclassifications: full recovery of peripheral blood counts: platelets >100,000/µl and ANC >1000/µl incomplete recovery of peripheral blood counts: platelets >50,000/µl but ≤100,000/µl; ANC >500/µl but ≤1000/µl ≤5% blasts in bone marrow No evidence of disease Full recovery of peripheral blood counts: platelets >100,000/μl, ANC >1500/μl hemoglobin ≥11 g/dl ≤5% blasts in bone marrow No evidence of disease Full recovery of peripheral blood counts: platelets >100,000/μl and ANC >1000/μl Complete remission with partial hematologic recovery (CRh) - ≤5% blasts in bone marrow No evidence of disease Full recovery of peripheral blood counts: platelets >50,000/μl, ANC >500/μl, and hemoglobin ≥7 g/dl ≤5% blasts in bone marrow No evidence of disease Partial recovery of peripheral blood counts: platelets >50,000/μl and ANC >500/μl Blast-free hypoplastic or aplastic bone marrow - - ≤5% blasts in bone marrow No evidence of disease Partial remission Complete disappearance of circulating blasts and achievement of M2 marrow status (≥5% or <25% blast cells) and appearance of normal progenitor cells ≤25% blasts in bone marrow 6%–25% blasts in bone marrow with a ≥50% reduction from baseline Hematological relapse >25% blasts in bone marrow after documented CR An extramedullary relapse was considered a relapse and was subdivided into CD19-positive and >5% blasts in bone marrow after documented CR/CRh An extramedullary relapse was assessed as hematological relapse >5% blasts in bone marrow, or blasts in peripheral blood after documented CR/CRh An extramedullary relapse was assessed as hematological relapse Abbreviations: ANC, absolute neutrophil count.