TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 5 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 7 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1. Environmental Exposure 10 7.1.2. Environmental Fate 11 7.1.3. Predicted Environmental Concentration (PEC) 11 7.2. Environmental Effects Assessment 11 7.2.1. Predicted No-Effect Concentration 12 7.3. Environmental Risk Assessment 12 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity oral 15 – B.2. Acute toxicity dermal 15 – B.3. Acute toxicity inhalation 16 – B.4. Irritation skin 17 – B.5. Irritation eye 17 – B.6. Skin sensitisation mouse local lymph node assay (LLNA) 18 – B.7. Repeat dose toxicity 19 B.8. Genotoxicity bacteria 20 – B.9. Genotoxicity in vitro 21 – Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.1. Environmental Fate 23 C.1.1. Ready biodegradability 23 C.2. Ecotoxicological Investigations 23 C.2.1. Acute toxicity to fish 23 C.2.2. Acute toxicity to aquatic invertebrates 24 C.2.3. Algal growth inhibition test 24 C.2.4. Inhibition of microbial activity 25 BIBLIOGRAPHY 26
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. PHYSICAL AND CHEMICAL PROPERTIES 5 5. INTRODUCTION AND USE INFORMATION 6 6. HUMAN HEALTH IMPLICATIONS 7 6.1. Exposure Assessment 7 6.1.1. Occupational Exposure 7 6.1.2. Public Exposure 7 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 10 7. ENVIRONMENTAL IMPLICATIONS 10 7.1. Environmental Exposure & Fate Assessment 10 7.1.1. Environmental Exposure 10 7.1.2. Environmental Fate 11 7.1.3. Predicted Environmental Concentration (PEC) 11 7.2. Environmental Effects Assessment 11 7.2.1. Predicted No-Effect Concentration 12 7.3. Environmental Risk Assessment 12 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity – oral 15 B.2. Acute toxicity – dermal 15 B.3. Acute toxicity – inhalation 16 B.4. Irritation – skin 17 B.5. Irritation – eye 17 B.6. Skin sensitisation – mouse local lymph node assay (LLNA) 18 B.7. Repeat dose toxicity 19 B.8. Genotoxicity – bacteria 20 B.9. Genotoxicity – in vitro 21 Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.1. Environmental Fate 23 C.1.1. Ready biodegradability 23 C.2. Ecotoxicological Investigations 23 C.2.1. Acute toxicity to fish 23 C.2.2. Acute toxicity to aquatic invertebrates 24 C.2.3. Algal growth inhibition test 24 C.2.4. Inhibition of microbial activity 25 BIBLIOGRAPHY 26