No. Location Prevalence Prevalence Age Male Etiology of HCC Child-Pugh who Definitions of large varices/ QUADAS author Regions total of of varices of description (year) (%) cirrhosis (%) class (%) underwent varices Score (Year) Pts varices (%) varices (%) endoscopy varices Non-confluent EV HBV 8.8%, protruding in the HCV 55.1%, A 79.4% Sebastiani despite insufflation; 2.2/ Italy Retrospective 510 59.5±11 58.0% alcohol 30.4%, 0.0% B 16.7% 510 EV 56.9% 19.0% 12 (2010) confluent thick EV, 2.5 cryptogenic or C 3.9% gastroesophageal junction others 5.7% varices and isolated GVs. Abbreviations: EV, esophageal varices; GV, gastric varices; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; NA, not available. Supplementary 12. Study quality: An overview of studies regarding FibroIndex for prediction of varices in liver cirrhosis. No. Item Sebastiani Was the spectrum of patients representative of the patients 1 Y who will receive the test in practice? 2 Were selection criteria clearly described? Y Is the reference standard likely to correctly classify the target 3 Y condition? Is the time period between reference standard and index test 4 short enough to be reasonably sure that the target condition Y did not change between the two tests? (≤3 months) Did the whole sample or a random selection of the sample, 5 Y receive verification using a reference standard of diagnosis? Did patients receive the same reference standard regardless 6 Y of the index test result? Was the reference standard independent of the index test (i.e. 7 Y the index test did not form part of the reference standard)? Was the execution of the index test described in sufficient 8 Y detail to permit replication of the test? Was the execution of the reference standard described in 9 Y sufficient detail to permit its replication? Were the index test results interpreted without knowledge of 10 U the results of the reference standard? Were the reference standard results interpreted without 11 U knowledge of the results of the index test?
author (Year) Regions description No. total Pts Age (year) Male (%) Etiology of cirrhosis HCC (%) Child-Pugh class (%) who underwent endoscopy Location of varices Prevalence of varices (%) Prevalence of varices (%) Definitions of large varices varices/ varices QUADAS Score Sebastiani (2010) Italy Retrospective 510 59.5±11 58.0% HBV 8.8%, HCV 55.1%, alcohol 30.4%, cryptogenic or others 5.7% 0.0% A 79.4% B 16.7% C 3.9% 510 EV 56.9% 19.0% Non-confluent EV protruding in the despite insufflation; confluent thick EV, gastroesophageal junction varices and isolated GVs. 2.2/ 2.5 12 Abbreviations: EV, esophageal varices; GV, gastric varices; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; NA, not available. Supplementary 12. Study quality: An overview of studies regarding FibroIndex for prediction of varices in liver cirrhosis. No. Item Sebastiani 1 Was the spectrum of patients representative of the patients who will receive the test in practice? Y 2 Were selection criteria clearly described? Y 3 Is the reference standard likely to correctly classify the target condition? Y 4 Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests? (≤3 months) Y 5 Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis? Y 6 Did patients receive the same reference standard regardless of the index test result? Y 7 Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)? Y 8 Was the execution of the index test described in sufficient detail to permit replication of the test? Y 9 Was the execution of the reference standard described in sufficient detail to permit its replication? Y 10 Were the index test results interpreted without knowledge of the results of the reference standard? U 11 Were the reference standard results interpreted without knowledge of the results of the index test? U