TABLE OF CONTENTS Full Public Report 4 1. APPLICANT AND NOTIFICATION DETAILS 4 2. IDENTITY OF CHEMICAL 4 3. 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 6 6.1 Exposure 6 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 7 6.3.1. Occupational health and safety 7 6.3.2. Public health 7 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 8 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 9 7.2.1 Predicted No-Effect Concentration 9 7.3. Environmental risk assessment 10 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 10 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity oral 15 – B.2. Acute toxicity dermal 15 – B.3. Irritation skin 16 – B.4. Irritation eye 16 – B.5. Skin sensitisation mouse local lymph node assay (LLNA) 17 – B.6. Repeat dose toxicity 18 B.7. Genotoxicity bacteria 19 – B.8. Genotoxicity in vitro 20 – Appendix C: Environmental Fate and Ecotoxicological Investigations 22 C.1. Environmental Fate 22 C.1.1. Ready biodegradability 22 C.2. Ecotoxicological Investigations 22 C.2.1. Acute toxicity to fish 22 C.2.2. Acute toxicity to aquatic invertebrates 23 C.2.3. Algal growth inhibition test 24 C.2.4. Inhibition of microbial activity 25 Bibliography 26
TABLE OF CONTENTS Full Public Report 4 1. APPLICANT AND NOTIFICATION DETAILS 4 2. IDENTITY OF CHEMICAL 4 3. 4 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 5 6. HUMAN HEALTH IMPLICATIONS 6 6.1 Exposure 6 6.1.1 Occupational exposure 6 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 7 6.3.1. Occupational health and safety 7 6.3.2. Public health 7 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 8 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 9 7.2.1 Predicted No-Effect Concentration 9 7.3. Environmental risk assessment 10 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 10 Appendix A: Physical and Chemical Properties 12 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity – oral 15 B.2. Acute toxicity – dermal 15 B.3. Irritation – skin 16 B.4. Irritation – eye 16 B.5. Skin sensitisation – mouse local lymph node assay (LLNA) 17 B.6. Repeat dose toxicity 18 B.7. Genotoxicity – bacteria 19 B.8. Genotoxicity – in vitro 20 Appendix C: Environmental Fate and Ecotoxicological Investigations 22 C.1. Environmental Fate 22 C.1.1. Ready biodegradability 22 C.2. Ecotoxicological Investigations 22 C.2.1. Acute toxicity to fish 22 C.2.2. Acute toxicity to aquatic invertebrates 23 C.2.3. Algal growth inhibition test 24 C.2.4. Inhibition of microbial activity 25 Bibliography 26