b. What are the goals, specific aims and hypotheses of this project/course? Include potential benefits to scientific knowledge. c. Provide a detailed description of exactly what will be done to the animals during this project/course table and a listing all control and experimental groups and the numbers of animals required per group as determined in Item 10. If using approved Western University Standard Operating Procedures (SOPs), provide the procedure codes here and ATTACH A COPY TO THIS APPLICATION. Note any deviations from the SOPs and attach a copy of each SOP. d. Provide the following information for all drugs, chemicals, toxins, infectious agents, viral vectors, cell lines or radioactivity to be given to the animals. The IACUC requires that all chemicals and other substances used in animals be of pharmaceutical-grade when available. If using substances, justify. Generic Name (indicate Controlled species to receive each Substance? (Y/N)* Purpose Dose Volume Interval Route agent) & Schedule Euthanizing Agent *Controlled substances used under this protocol MUST be covered by a DEA license. A link to the application form may be found on the under Important Forms. i. Provide the name and contact information of the person with a valid DEA license who will provide the controlled substance(s). Office phone: Email: e. If paralytic/neuromuscular blockers are used, justify their use and describe how the absence of pain and the absence of consciousness will be assessed. 14. Literature Search A literature search must be performed to determine that (i) this study/course does not – unnecessarily duplicate previous work, (ii) there are no alternatives to the use of live animals, and (iii) there are no alternatives to procedures that may cause more than momentary or slight pain or distress to the animals (Pain Categories D and E above). a. Date of Search (must be within the last 6 months of submission): b. Identify databases used (minimum (e.g., PubMed, Biological Abstracts, Animal of 2 required): Welfare Information Center Altweb).
b. What are the goals, specific aims and hypotheses of this project/course? Include potential benefits to scientific knowledge. c. Provide a detailed description of exactly what will be done to the animals during this project/course and a table listing all control and experimental groups and the numbers of animals required per group as determined in Item 10. If using approved Western University Standard Operating Procedures (SOPs), provide the procedure codes here and ATTACH A COPY TO THIS APPLICATION. Note any deviations from the SOPs and attach a copy of each SOP. d. Provide the following information for all drugs, chemicals, toxins, infectious agents, viral vectors, cell lines or radioactivity to be given to the animals. The IACUC requires that all chemicals and other substances used in animals be of pharmaceutical-grade when available. If using substances, justify. Generic Name (indicate species to receive each agent) Controlled Substance? (Y/N)* & Schedule Purpose Dose Volume Interval Route Euthanizing Agent *Controlled substances used under this protocol MUST be covered by a DEA license. A link to the application form may be found on the under Important Forms. i. Provide the name and contact information of the person with a valid DEA license who will provide the controlled substance(s). Office phone: Email: e. If paralytic/neuromuscular blockers are used, justify their use and describe how the absence of pain and the absence of consciousness will be assessed. 14. Literature Search – A literature search must be performed to determine that (i) this study/course does not unnecessarily duplicate previous work, (ii) there are no alternatives to the use of live animals, and (iii) there are no alternatives to procedures that may cause more than momentary or slight pain or distress to the animals (Pain Categories D and E above). a. Date of Search (must be within the last 6 months of submission): b. Identify databases used (minimum of 2 required): (e.g., PubMed, Biological Abstracts, Animal Welfare Information Center Altweb).