Table 6 Summary of adverse events, by intervention Interventions Daily dose Adverse Events reported when use in the treatment of Authors – menopausal symptoms in peri- and postmenopausal asthenia hypertension anorexia constipation 100mg or 150mg (greater diarrhea Berhan 201411; Sun Desvenlafaxine* discontinuation with dosage dry mouth 201312 nausea ≥150mg) dizziness insomnia somnolence mydriasis postmenopausal bleeding Transdermal oestradiol (Divigel 0.25 headache mg, Divigel 0.5 mg, Estrogel 0.75 mg, breast pain and Estrogel* 1.5 and 0.5 mg; 0.25mg to 1.5mg / 0.003 to Derzko Corbelli infection Menostar, Evamist, Divigel, Vivelle, 2015**9 nausea Dermestril, Elestrin, Fempatch, rash Esclim: 0.003mg-0.125mg) vaginitis endometrial thickness* Ospemifene 60mg Cui 20147 hot flushes needling pain 2 times per week for 4 weeks, bleeding at the site of needling Acupuncture stainless-steel filiform 0.20 x 30 Dodin 201320 mm needles) Not all RCTs in the SR reported adverse events 2.5mg methyl testosterone, acne with or without 1.25mg Testosterone with or without hirsutism Elraiyah 201431 esterified oestrogen reduction in total cholesterol androgenic side effects oestrogen breast cancer endometrial cancer venous thromboembolic events Nastri 2013**25; Tibolone 2.5mg cardiovascular events Formoso cerebrovascular events mortality from any cause
Table 6 Summary of adverse events, by intervention Interventions Daily dose Adverse Events – reported when use in the treatment of menopausal symptoms in peri- and postmenopausal Authors Desvenlafaxine* 100mg or 150mg (greater discontinuation with dosage ≥150mg) asthenia hypertension anorexia constipation diarrhea dry mouth nausea dizziness insomnia somnolence mydriasis Berhan 201411; Sun 201312 Transdermal oestradiol (Divigel 0.25 mg, Divigel 0.5 mg, Estrogel 0.75 mg, and Estrogel* 1.5 and 0.5 mg; Menostar, Evamist, Divigel, Vivelle, Dermestril, Elestrin, Fempatch, Esclim: 0.003mg-0.125mg) 0.25mg to 1.5mg / 0.003 to postmenopausal bleeding headache breast pain infection nausea rash vaginitis Derzko Corbelli 2015**9 Ospemifene 60mg endometrial thickness* hot flushes Cui 20147 Acupuncture 2 times per week for 4 weeks, stainless-steel filiform 0.20 x 30 mm needles) needling pain bleeding at the site of needling Not all RCTs in the SR reported adverse events Dodin 201320 Testosterone with or without oestrogen 2.5mg methyl testosterone, with or without 1.25mg esterified oestrogen acne hirsutism reduction in total cholesterol androgenic side effects Elraiyah 201431 Tibolone 2.5mg breast cancer endometrial cancer venous thromboembolic events cardiovascular events cerebrovascular events mortality from any cause Nastri 2013**25; Formoso