TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity oral 15 – B.2. Acute toxicity dermal 15 – B.3. Irritation skin 16 – B.4. Irritation eye 16 – B.5. Skin sensitisation 17 B.6. Repeat dose toxicity 18 B.7. Genotoxicity in vitro 20 – B.8. Genotoxicity in vitro 21 – Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.1. Environmental Fate 23 C.2. Ecotoxicological Investigations 23 C.2.1. Acute toxicity to fish 23 C.2.2. Acute toxicity to aquatic invertebrates 24 C.2.3. Algal growth inhibition test 25 BIBLIOGRAPHY 26
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity – oral 15 B.2. Acute toxicity – dermal 15 B.3. Irritation – skin 16 B.4. Irritation – eye 16 B.5. Skin sensitisation 17 B.6. Repeat dose toxicity 18 B.7. Genotoxicity – in vitro 20 B.8. Genotoxicity – in vitro 21 Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.1. Environmental Fate 23 C.2. Ecotoxicological Investigations 23 C.2.1. Acute toxicity to fish 23 C.2.2. Acute toxicity to aquatic invertebrates 24 C.2.3. Algal growth inhibition test 25 BIBLIOGRAPHY 26