PART 4 SUMMARY OF EVIDENCE – # Type of study Title of journal article or description of research (max 50 Website link to journal article or Date of design* research project (including words)** research (if available) publication*** any identifier or study lead if relevant) 1. Retrospective Chalouhi 2013b. Comparison A significantly higher proportion of aneurysms 2013 cohort trial; 1:3 of flow diversion and coiling in treated with PED (86%) achieved complete matched pair large unruptured intracranial obliteration compared with coiled aneurysms comparison saccular aneurysms. (41%; P<0.001). Retreatment was necessary in patients in the PED group (2.8%) than the coil group (37%; P<0.001). 2. Retrospective Chalouhi 2014. Extending the At follow-up, a higher proportion of aneurysms 2014 cohort study; 1:4 indications of flow diversion to treated with PED (80%) achieved complete matched pair small, unruptured, saccular obliteration compared with comparison aneurysms of the anterior aneurysms (70%) (P=0.2). Rate of circulation. periprocedural complications were similar between groups. 3. Retrospective Chalouhi 2017. Matched Complete occlusion (100%) at follow-up was 2017 cohort study with Comparison of Flow Diversion significantly higher in patients treated with PED historical control, and Coiling in Small, (70%) than coiling (47.5%, P = 0.04). A matched Noncomplex Intracranial significantly higher proportion of coiled patients comparison; Aneurysms. (32.5%) required retreatment compared with consecutive; III-3 FD (5%, P = 0.003). All patients achieved a favourable outcome (modified Rankin Trial: 0-2) regardless of group.
PART 4 – SUMMARY OF EVIDENCE # Type of study design* Title of journal article or research project (including any identifier or study lead if relevant) description of research (max 50 words)** Website link to journal article or research (if available) Date of publication*** 1. Retrospective cohort 1:3 matched pair comparison Chalouhi 2013b. Comparison of flow diversion and coiling in large unruptured intracranial saccular aneurysms. A significantly higher proportion of aneurysms treated with PED (86%) achieved complete obliteration compared with coiled aneurysms (41%; P<0.001). Retreatment was necessary in patients in the PED group (2.8%) than the coil group (37%; P<0.001). 2013 2. Retrospective cohort study; 1:4 matched pair comparison Chalouhi 2014. Extending the indications of flow diversion to small, unruptured, saccular aneurysms of the anterior circulation. At follow-up, a higher proportion of aneurysms treated with PED (80%) achieved complete obliteration compared with aneurysms (70%) (P=0.2). Rate of periprocedural complications were similar between groups. 2014 3. Retrospective cohort study with historical control, matched comparison; consecutive; III-3 Chalouhi 2017. Matched Comparison of Flow Diversion and Coiling in Small, Noncomplex Intracranial Aneurysms. Complete occlusion (100%) at follow-up was significantly higher in patients treated with PED (70%) than coiling (47.5%, P = 0.04). A significantly higher proportion of coiled patients (32.5%) required retreatment compared with FD (5%, P = 0.003). All patients achieved a favourable outcome (modified Rankin 0-2) regardless of group. 2017 Trial: trial;