Table Model parameters and sources Parameter Base case value Range Distribution Distribution parameters Source(s) applied Perinatal transmission rate H&V 0.0962 Beta α, β (75,704) [] 0.0481-0.1443 σ RR (LAM vs. H&V)a 0.31 Lognormal u, (-1.27, 0.45) [] 0.15-0.63 σ RR (LdT vs. LAM)b 0.11 Lognormal u, (-2.41, 0.63) [] 0.04-0.31 σ RR (TDF vs. LdT)c 0.05 Lognormal u, (-3.22, 0.67) Assumed 0.01-0.10 Annual transition probabilities related to chronic infection Asymptomatic carrier To immune (clearance of 0.01 0-0.015 Gamma α, λ(8, 1531) [] HBV) To chronic hepatitis [] 0-19 years 0.0012 20-39 years 0.0023 ±50% － － ≥40 years 0.0054 To hepatocellular carcinoma [, , ] 0-19 years 0.0005 20-39 years 0.0020 ±50% － － ≥40 years 0.0061 Chronic hepatitis To asymptomatic carrier 0.015 0-0.05 Gamma α, λ(5, 988) [, ] To compensated cirrhosis 0.015 [, , , , ] 0-19 years 0.02 ±50% － － 20-39 years 0.027 ≥40 years To hepatocellular carcinoma [9, 11, 13, 14, 16]
Table Model parameters and sources Parameter Base case value Range Distribution applied Distribution parameters Source(s) Perinatal transmission rate H&V 0.0962 0.0481-0.1443 Beta α, β (75,704) [] RR (LAM vs. H&V)a 0.31 0.15-0.63 Lognormal u, σ (-1.27, 0.45) [] RR (LdT vs. LAM)b 0.11 0.04-0.31 Lognormal u, σ (-2.41, 0.63) [] RR (TDF vs. LdT)c 0.05 0.01-0.10 Lognormal u, σ (-3.22, 0.67) Assumed Annual transition probabilities related to chronic infection Asymptomatic carrier To immune (clearance of HBV) 0.01 0-0.015 Gamma α, λ(8, 1531) [] To chronic hepatitis 0-19 years 20-39 years ≥40 years 0.0012 0.0023 0.0054 ±50% － － [] To hepatocellular carcinoma 0-19 years 20-39 years ≥40 years 0.0005 0.0020 0.0061 ±50% － － [, , ] Chronic hepatitis To asymptomatic carrier 0.015 0-0.05 Gamma α, λ(5, 988) [, ] To compensated cirrhosis 0-19 years 20-39 years ≥40 years 0.015 0.02 0.027 ±50% － － [, , , , ] To hepatocellular carcinoma [9, 11, 13, 14, 16]