recommendation; c. Approve the proposal for registration in PROSPERO. d. If in the unusual circumstance that no important outcomes are found the review may not continue at this point; e. Register the protocol in PROSPERO. Data extraction, verification and cleaning and prep of Data extraction, draft meta- analyses (where verification and appropriate) and a priori 4 cleaning and prep of sub-group analysis (Tables 6 6-Jan-18 17-Feb-18 draft meta- analyses and Figures), including (where appropriate) contacting authors for missing data or incomplete data (if appropriate) Review of tables with Domain Lead, 5 content experts and 1 17-Feb-18 24-Feb-18 Y Y Y approval by the relevant TFs Completion of Evidence Profile Tables using GRADE PRO GTD online resource () Completion of so as to allow seamless 6 Evidence Profile integration into the Task 3 25-Feb-18 18-Mar-18 Tables force preparation of the Evidence to Decision Table for formulating recommendations Review of Evidence Profile 7. Review of Tables using GRADE PRO Evidence Profile GTD online resource () with 7 Tables using GRADE 1 19-Mar-18 26-Mar-18 Y Y Y Domain Leads (DLs), PRO GTD online content experts and resource relevant TFs and obtain
recommendation; c. Approve the proposal for registration in PROSPERO. d. If in the unusual circumstance that no important outcomes are found the review may not continue at this point; e. Register the protocol in PROSPERO. 4 Data extraction, verification and cleaning and prep of draft meta- analyses (where appropriate) Data extraction, verification and cleaning and prep of draft meta- analyses (where appropriate) and a priori sub-group analysis (Tables and Figures), including contacting authors for missing data or incomplete data (if appropriate) 6 6-Jan-18 17-Feb-18 5 Review of tables with Domain Lead, content experts and approval by the relevant TFs 1 17-Feb-18 24-Feb-18 Y Y Y 6 Completion of Evidence Profile Tables Completion of Evidence Profile Tables using GRADE PRO GTD online resource () so as to allow seamless integration into the Task force preparation of the Evidence to Decision Table for formulating recommendations 3 25-Feb-18 18-Mar-18 7 7. Review of Evidence Profile Tables using GRADE PRO GTD online resource Review of Evidence Profile Tables using GRADE PRO GTD online resource () with Domain Leads (DLs), content experts and relevant TFs and obtain 1 19-Mar-18 26-Mar-18 Y Y Y