Consumer Product Testing Inc (1986) Irritation skin (in vivo) (2) – Notified chemical Similar to OECD TG 404 Acute Dermal Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals 3M Vehicle - Observation Period 7 days Type of Dressing Not stated Remarks - Method Tabular summary only provided, and the test period was not specified. Remarks - Results No erythema or oedema was observed at the 24, 48 or 72 h observations. The notified chemical was non-irritating to the skin under the conditions of the study. Cosmeer (1995) Irritation eye (1) – Notified chemical Similar to OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals Observation Period Remarks - Method Tabular summary only provided. Observation period was 7 days. Lesion Mean Score* Maximum Maximum Duration Maximum Value at End Animal No. Value of Any Effect of Observation Period 1 2 3 0.3 0.3 0.7 4 < 72 h 0 Conjunctival effects 0 0 0 0 - 0 Corneal opacity 0 0 0 0 - 0 Iridial inflammation *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results Conjunctival effects were not distinguished as redness, chemosis or discharge. Severe conjunctival effects were seen at 1 h, which had reduced to slight effects at 24 h, and resolved by 72 h in all animals. The notified chemical is slightly irritating to the eye. Cosmeer (1995) Skin sensitisation mouse local lymph node assay (LLNA) – Notified chemical OECD TG 429 Skin Sensitisation: Local Lymph Node Assay EC Directive 2004/73/EC B.42 Skin Sensitisation (Local Lymph Node Assay)
Consumer Product Testing Inc (1986) Irritation – skin (in vivo) (2) Notified chemical Similar to OECD TG 404 Acute Dermal Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals 3M Vehicle - Observation Period 7 days Type of Dressing Not stated Remarks - Method Tabular summary only provided, and the test period was not specified. Remarks - Results No erythema or oedema was observed at the 24, 48 or 72 h observations. The notified chemical was non-irritating to the skin under the conditions of the study. Cosmeer (1995) Irritation – eye (1) Notified chemical Similar to OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals Observation Period Remarks - Method Tabular summary only provided. Observation period was 7 days. Lesion Mean Score* Animal No. Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Conjunctival effects 0.3 0.3 0.7 4 < 72 h 0 Corneal opacity 0 0 0 0 - 0 Iridial inflammation 0 0 0 0 - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results Conjunctival effects were not distinguished as redness, chemosis or discharge. Severe conjunctival effects were seen at 1 h, which had reduced to slight effects at 24 h, and resolved by 72 h in all animals. The notified chemical is slightly irritating to the eye. Cosmeer (1995) Skin sensitisation – mouse local lymph node assay (LLNA) Notified chemical OECD TG 429 Skin Sensitisation: Local Lymph Node Assay EC Directive 2004/73/EC B.42 Skin Sensitisation (Local Lymph Node Assay)