Guthrie 20152; Reed et Venlafaxine** 75mg No reported adverse events related to sexual dysfunction al (2014) - (MsFLASH 03)36 nausea fatigue dry somnolence/drowsiness sleep disturbance Shams 201410; sweatiness Guthrie 2015**2; Escitalopram 10-20mg dizziness/vertigo Freeman 2011 - headache (MsFLASH 01)13 decrease libido rash vivid dreams appetite change conjugated oestrogens: 0.45 Guthrie 2015**2; Nastri mg, oestradiol gel: 0.87g/d - insomnia 2013**25; Joffe et al 2.6 g/d Low-dose oral oestradiol fatigue (2014) - (MsFLASH 03)26 0.5mg No women reported adverse events related to sexual Reed et al (2014) - Oral oestradiol** 0.5mg dysfunction (MsFLASH 03)3 back pain Woods 2014**15; muscle aches and pains Daley 2014**14; 45min 5 times a week; 60min 3 Exerciseᶧ heart palpitations Guthrie 2015**2; times a week dizziness Sternfeld et al (2014) - fainting (MsFLASH 02)16 Woods 2014**15; muscle ache and pains Guthrie 2015**2; Yogaᶧ 12 weekly 90-minute classes low back pain Newton et al (2014) - changes in strength or sensation in the arms or legs (MsFLASH 02)17 Burping / belching Guthrie 2015**2; Bad breath or aftertaste Omega-3ᶧ 1.8g Heartburn Cohen et al (2014) - (MsFLASH 02)24 Nausea Vomiting
Venlafaxine** 75mg No reported adverse events related to sexual dysfunction Guthrie 20152; Reed et al (2014) - (MsFLASH 03)36 Escitalopram 10-20mg nausea fatigue dry somnolence/drowsiness sleep disturbance sweatiness dizziness/vertigo headache decrease libido rash vivid dreams appetite change Shams 201410; Guthrie 2015**2; Freeman 2011 - (MsFLASH 01)13 Low-dose oral oestradiol conjugated oestrogens: 0.45 mg, oestradiol gel: 0.87g/d - 2.6 g/d 0.5mg insomnia fatigue Guthrie 2015**2; Nastri 2013**25; Joffe et al (2014) - (MsFLASH 03)26 Oral oestradiol** 0.5mg No women reported adverse events related to sexual dysfunction Reed et al (2014) - (MsFLASH 03)3 Exerciseᶧ 45min 5 times a week; 60min 3 times a week back pain muscle aches and pains heart palpitations dizziness fainting Woods 2014**15; Daley 2014**14; Guthrie 2015**2; Sternfeld et al (2014) - (MsFLASH 02)16 Yogaᶧ 12 weekly 90-minute classes muscle ache and pains low back pain changes in strength or sensation in the arms or legs Woods 2014**15; Guthrie 2015**2; Newton et al (2014) - (MsFLASH 02)17 Omega-3ᶧ 1.8g Burping / belching Bad breath or aftertaste Heartburn Nausea Vomiting Guthrie 2015**2; Cohen et al (2014) - (MsFLASH 02)24