EB risk of bias: High Vasomotor menopausal symptom scores, promensil vs. placebo: WMD 0.10 (- 1.54, 1.74); 1 RCT (N=165) There was no evidence that phytoestrogens effectively reduce hot flush frequency or severity. Authors’ conclusion: is no evidence of effectiveness in the alleviation of menopausal symptoms with the use of phytoestrogen “There treatments.” Leach and Moore (2012)23, black cohosh 16 RCTs (N=2027) Peri- and Trial cohosh (40 1. Placebo Hot flush Hot flush frequency, (1)Yes. Searched postmenopausal mg/d over an 2. Hormone frequency black cohosh vs. Pubmed, EMBASE, women. Women average of 23 therapy placebo: CENTRAL, CINAHL with breast weeks) 3. Red clover Hot flush MD 0.07 (- 0.43, 0.56); 3 and other cancer were 4. Fluoxetine severity RCTs (N=393) databases. included. (2)Yes. Quality sweat Hot flush severity, black assessed by two frequency cohosh vs. placebo: reviewers using MD 0.12 (- 0.06, 0.3); 3 GRADE. Menopausal RCTs (N=214) (3)Yes. symptom (4)Yes. scores sweat SR risk of bias: Low frequency/score, black EB risk of bias: cohosh vs. placebo: Unclear MD 0.27 (- 0.16, 0.70); 1 RCT (N=164)
Vasomotor menopausal symptom scores, promensil vs. placebo: WMD 0.10 (- 1.54, 1.74); 1 RCT (N=165) There was no evidence that phytoestrogens effectively reduce hot flush frequency or severity. EB risk of bias: High Authors’ conclusion: “There is no evidence of effectiveness in the alleviation of menopausal symptoms with the use of phytoestrogen treatments.” Leach and Moore (2012)23, black cohosh 16 RCTs (N=2027) Peri- and postmenopausal women. Women with breast cancer were included. cohosh (40 mg/d over an average of 23 weeks) 1. Placebo 2. Hormone therapy 3. Red clover 4. Fluoxetine Hot flush frequency Hot flush severity sweat frequency Menopausal symptom scores Hot flush frequency, black cohosh vs. placebo: MD 0.07 (- 0.43, 0.56); 3 RCTs (N=393) Hot flush severity, black cohosh vs. placebo: MD 0.12 (- 0.06, 0.3); 3 RCTs (N=214) sweat frequency/score, black cohosh vs. placebo: MD 0.27 (- 0.16, 0.70); 1 RCT (N=164) (1)Yes. Searched Pubmed, EMBASE, CENTRAL, CINAHL and other databases. (2)Yes. Quality assessed by two reviewers using GRADE. (3)Yes. (4)Yes. SR risk of bias: Low EB risk of bias: Unclear Trial