Internet Resources, Chapter 2, Water, Acids, Bases, and Buffers <tabA2.1>Table A2.1 Acids in the Blood of a Healthy Individual <T2>Acid Anion pKa Major Sources <T>Strong acid Sulfuric acid Sulfate Completely Dietary sulfate and (H2SO4) dissociated amino acids SO4−2 Weak acid Carbonic acid Bicarbonate 3.80 CO2 from TCA cycle (R-COOH) (R-COO− ) Lactic acid Lactate 3.73 Anaerobic glycolysis (R-COOH) (R-COO− ) Pyruvic acid Pyruvate 2.39 Glycolysis (R-COOH) (R-COO−) Citric acid Citrate 3.13; 4.76; TCA cycle and diet (R-3COOH) (R-3COO−) 6.40 (e.g., citrus fruits) Acetoacetic acid Acetoacetate 3.62 Fatty acid oxidation to (R-COOH) (R-COO−) ketone bodies acid 4.41 Fatty acid oxidation to β-Hydroxybutyric β-Hydroxybutyrate (R-COOH) (R-COO−) ketone bodies Acetic acid Acetate 4.76 Ethanol metabolism (R-COOH) (R-COO−) Dihydrogen phosphate Monohydrogen 6.8 Dietary organic
Internet Resources, Chapter 2, Water, Acids, Bases, and Buffers <tabA2.1>Table A2.1 Acids in the Blood of a Healthy Individual <T2>Acid Anion pKa Major Sources <T>Strong acid Sulfuric acid (H2SO4) Sulfate SO4−2 Completely dissociated Dietary sulfate and amino acids Weak acid Carbonic acid (R-COOH) Bicarbonate (R-COO− ) 3.80 CO2 from TCA cycle Lactic acid (R-COOH) Lactate (R-COO− ) 3.73 Anaerobic glycolysis Pyruvic acid (R-COOH) Pyruvate (R-COO−) 2.39 Glycolysis Citric acid (R-3COOH) Citrate (R-3COO−) 3.13; 4.76; 6.40 TCA cycle and diet (e.g., citrus fruits) Acetoacetic acid (R-COOH) Acetoacetate (R-COO−) 3.62 Fatty acid oxidation to ketone bodies β-Hydroxybutyric acid (R-COOH) β-Hydroxybutyrate (R-COO−) 4.41 Fatty acid oxidation to ketone bodies Acetic acid (R-COOH) Acetate (R-COO−) 4.76 Ethanol metabolism Dihydrogen phosphate Monohydrogen 6.8 Dietary organic