Supplementary Table S1: Diagnostic accuracy for subgroup analysis: Subgroups Pooled sensitivity Pooled specificity (95% CI) PLR (95% CI) NLR (95% CI) DOR (95% CI) LRT_ I2 (95% LRT_ Q (p) (95% CI) DC HC CI) 0.6 (0.45, 0.74) 0.97 1.00 28.2 0.41 (0.28, 0.59) 69 (17, 285) 99 (98, 99) 148.821 (0.89, 0.99) (0.86,1.00) (7.1,111.7) (p<0.001) isolation non- 0.82 (0.66, 0.91) 0.98 1.00 144.0 0.18 (0.09, 0.36) 795 (18, 34434) 93 (87, 99) 28.786 (0.90, 1.00) (0.89,1.00) isolation (3.4, 6174.5) (p<0.001) Immunostaining 0.66(0.47, 0.81) 1.00 1.00 1035.9 0.34 (0.20, 0.58) 3051 93 (86, 99) 26.688 (0.95, 1.00) (0.91,1.00) identification (6.2, 173850.7) (18, 531663) (p<0.001) RNA identification 0.6 (0.35, 0.8) 0.96 1.00 29.3 0.41 (0.22, 0.76) 71 (8, 608) 95 (91-99) 39.715 (0.85, 0.99) (0.80,1.00) (4.5, 193.1) (p<0.001) Abbreviations: PLR, Positive Likelihood Ratio; NLR, Negative Likelihood Ratio; DOR, Diagnostic Odds Ratio; 95% CI, 95% confidence interval; p, p value; DC, Diseases control; HC, Healthy control;
Supplementary Table S1: Diagnostic accuracy for subgroup analysis: Subgroups Pooled sensitivity (95% CI) Pooled specificity (95% CI) DC HC PLR (95% CI) NLR (95% CI) DOR (95% CI) LRT_ I2 (95% CI) LRT_ Q (p) isolation 0.6 (0.45, 0.74) 0.97 (0.89, 0.99) 1.00 (0.86,1.00) 28.2 (7.1,111.7) 0.41 (0.28, 0.59) 69 (17, 285) 99 (98, 99) 148.821 (p<0.001) non- isolation 0.82 (0.66, 0.91) 0.98 (0.90, 1.00) 1.00 (0.89,1.00) 144.0 (3.4, 6174.5) 0.18 (0.09, 0.36) 795 (18, 34434) 93 (87, 99) 28.786 (p<0.001) Immunostaining identification 0.66(0.47, 0.81) 1.00 (0.95, 1.00) 1.00 (0.91,1.00) 1035.9 (6.2, 173850.7) 0.34 (0.20, 0.58) 3051 (18, 531663) 93 (86, 99) 26.688 (p<0.001) RNA identification 0.6 (0.35, 0.8) 0.96 (0.85, 0.99) 1.00 (0.80,1.00) 29.3 (4.5, 193.1) 0.41 (0.22, 0.76) 71 (8, 608) 95 (91-99) 39.715 (p<0.001) Abbreviations: PLR, Positive Likelihood Ratio; NLR, Negative Likelihood Ratio; DOR, Diagnostic Odds Ratio; 95% CI, 95% confidence interval; p, p value; DC, Diseases control; HC, Healthy control;