Diarrhea Constipation Mild flu-like symptoms Dizziness or fainting palpitations Skin rash Muscle aches / strains Strength / sensations of arms / legs change Back pain Bruising or bleeding gastrointestinal cohoshᶧ 6.5 mg to 160 mg musculoskeletal Leach 201223 connective tissue complaints bloating nausea Phytoestrogens Lethaby 201321 weight gain concerns about bowel function breast tenderness oedema joint pain psychological symptoms 0.87g -2.6 g; 1- 2mg oestradiol; MacLennan Nastri Oral hormone therapy 0.625 to 1.25 mg CEE 2013**25 Adverse events related to HT were not included as outcomes because Nastri 2013 only included trials that reported sexual function bazedoxifene: 20 mg plus conjugated estrogens: 0.45 mg bazedoxifene: 20 mg plus conjugated estrogens: 0.625 Adverse events related to HT were not included as outcomes mg Tibolone or SERMs with or without because Nastri 2013**25 estrogens conjugated equine estrogens: Nastri 2013 only included trials that reported sexual function 0.625 mg raloxifene: 60mg or 150mg transdermal estradiol therapy: 50mcg/24 hours
Diarrhea Constipation Mild flu-like symptoms Dizziness or fainting palpitations Skin rash Muscle aches / strains Strength / sensations of arms / legs change Back pain Bruising or bleeding cohoshᶧ 6.5 mg to 160 mg gastrointestinal musculoskeletal connective tissue complaints Leach 201223 Phytoestrogens bloating nausea weight gain concerns about bowel function Lethaby 201321 Oral hormone therapy 0.87g -2.6 g; 1- 2mg oestradiol; 0.625 to 1.25 mg CEE breast tenderness oedema joint pain psychological symptoms Adverse events related to HT were not included as outcomes because Nastri 2013 only included trials that reported sexual function MacLennan Nastri 2013**25 Tibolone or SERMs with or without estrogens bazedoxifene: 20 mg plus conjugated estrogens: 0.45 mg bazedoxifene: 20 mg plus conjugated estrogens: 0.625 mg conjugated equine estrogens: 0.625 mg raloxifene: 60mg or 150mg transdermal estradiol therapy: 50mcg/24 hours Adverse events related to HT were not included as outcomes because Nastri 2013 only included trials that reported sexual function Nastri 2013**25