0.5mg daily for ratio or weighted ring; 2 2 weeks Oestrogen tablets mean difference. mg micronized followed versus oestrogen cream (4)Yes. Statistical and 17B oestradiol by effect size clinical – with a constant maintenance Vaginal pH (decrease), heterogeneity was release dose 0.5 mg 3 -0.20 [-0.38, -0.02] explored. of 7.5 mcg times a week, Dyspareunia, 0.53 [0.36, SR risk of bias: Low oestradiol/24 or oestrogenic 0.78] EB risk of bias: hours for 90 days; cream Moderate Vaginal ring Oestrogen versus delivering 50or (Cilag), 0.5 Replens moisturising gel 100ug/day; mg daily for 2 (non-hormonal) effect – conjugated weeks then 3 size equine oestrogen times a week Maturation value cream 2g/daily or for 3 months), (increased), -4.69 3 times a week; or oestradiol 4.20] oestradiol vaginal pessary 0.5 mg Vaginal pH (decrease), ring (Ovestin), or 0.20 [-0.12, 0.52] 7.5mcg/24hours) tablets Dyspareunia, 3.5 [0.80, 15.34] Oestradiol tablets versus oestriol tablets – effect size Maturation (high or medium), 1.83 [0.59, 5.66] Withdrawal due to adverse events, 7.46 [0.37, 148.48] Vaginal pH (decrease), -0.36 [-0.52, -0.21]
ring; 2 mg micronized 17B oestradiol with a constant release of 7.5 mcg oestradiol/24 hours for 90 days; Vaginal ring delivering 50or 100ug/day; conjugated equine oestrogen cream 2g/daily or 3 times a week; oestradiol vaginal ring 7.5mcg/24hours) 0.5mg daily for 2 weeks followed by maintenance dose 0.5 mg 3 times a week, or oestrogenic cream (Cilag), 0.5 mg daily for 2 weeks then 3 times a week for 3 months), or oestradiol pessary 0.5 mg (Ovestin), or tablets Oestrogen tablets versus oestrogen cream – effect size Vaginal pH (decrease), -0.20 [-0.38, -0.02] Dyspareunia, 0.53 [0.36, 0.78] Oestrogen versus Replens moisturising gel (non-hormonal) – effect size Maturation value (increased), -4.69 4.20] Vaginal pH (decrease), 0.20 [-0.12, 0.52] Dyspareunia, 3.5 [0.80, 15.34] Oestradiol tablets versus oestriol tablets – effect size Maturation (high or medium), 1.83 [0.59, 5.66] Withdrawal due to adverse events, 7.46 [0.37, 148.48] Vaginal pH (decrease), -0.36 [-0.52, -0.21] ratio or weighted mean difference. (4)Yes. Statistical and clinical heterogeneity was explored. SR risk of bias: Low EB risk of bias: Moderate