Disease Type of keratosis Significance and treatment dermatitis Variable focal to diffuse parakeratosis with Partial to significant response to Malassezia associated with orthokeratosis and scale over spongiotic, KTZ or ITZ and topical antimicrobial various allergies ( dog hyperplastic epidermis and follicular shampoo. May still leave obvious signs and cat) infundubulae. Some sections may only of allergy. have marked compact orthokeratosis. Canine seborrhoeic As above although follicular keratosis Up to complete response to systemic dermatitis (as a tends to be a minor feature and dermal or topical antifungal and descriptive term). infiltrate is dominated by mast cells, with antistaphylococcal antimicrobial lesser numbers of histiocytes and therapy in certain breeds (such as lymphocytes. Basset hounds). Lethal acrodermatitis Thickened diffuse parakeratosis over a Treating yeast / bacterial infection of Bull terriers, zinc variable pale swollen keratinocyte layer in extends life of lethal acrodermatitis. In responsive and a hyperplastic epidermis and prominent all syndromes the inflammation is generic dog food basal cell layer. reduced, but prominent parakeratosis dermatosis; superficial and hyperplasia remains. necrolytic dermatitis.
Disease Type of keratosis Significance and treatment Malassezia dermatitis associated with various allergies ( dog and cat) Variable focal to diffuse parakeratosis with orthokeratosis and scale over spongiotic, hyperplastic epidermis and follicular infundubulae. Some sections may only have marked compact orthokeratosis. Partial to significant response to KTZ or ITZ and topical antimicrobial shampoo. May still leave obvious signs of allergy. Canine seborrhoeic dermatitis (as a descriptive term). As above although follicular keratosis tends to be a minor feature and dermal infiltrate is dominated by mast cells, with lesser numbers of histiocytes and lymphocytes. Up to complete response to systemic or topical antifungal and antistaphylococcal antimicrobial therapy in certain breeds (such as Basset hounds). Lethal acrodermatitis of Bull terriers, zinc responsive and generic dog food dermatosis; superficial necrolytic dermatitis. Thickened diffuse parakeratosis over a variable pale swollen keratinocyte layer in a hyperplastic epidermis and prominent basal cell layer. Treating yeast / bacterial infection extends life of lethal acrodermatitis. In all syndromes the inflammation is reduced, but prominent parakeratosis and hyperplasia remains.