List of abbreviations Abbreviation Meaning ADME absorption, distribution, metabolism, and excretion AE adverse event AESI adverse event of special interest AIC Akaike information criterion ALAG absorption lag time ALP alkaline phosphatase ALT alanine aminotransferase ANC absolute neutrophil counts API active pharmaceutical ingredient AST aspartate aminotransferase AUC area under the concentration-time curve AusPAR Australian Public Assessment Reports BA bioavailability BMI body mass index BSA body surface area CF cystic fibrosis CFF US Cystic Fibrosis Society CFQ-R Cystic Fibrosis Questionnaire Revised – CFTR CF transmembrane conductance regulator CHMP Committee for Medicinal Products for Human Use (EMA) CI confidence interval CL/F clearance CLss/F apparent clearance at steady state Cmax maximum observed concentration
List of abbreviations Abbreviation Meaning ADME absorption, distribution, metabolism, and excretion AE adverse event AESI adverse event of special interest AIC Akaike information criterion ALAG absorption lag time ALP alkaline phosphatase ALT alanine aminotransferase ANC absolute neutrophil counts API active pharmaceutical ingredient AST aspartate aminotransferase AUC area under the concentration-time curve AusPAR Australian Public Assessment Reports BA bioavailability BMI body mass index BSA body surface area CF cystic fibrosis CFF US Cystic Fibrosis Society CFQ-R Cystic Fibrosis Questionnaire – Revised CFTR CF transmembrane conductance regulator CHMP Committee for Medicinal Products for Human Use (EMA) CI confidence interval CL/F clearance CLss/F apparent clearance at steady state Cmax maximum observed concentration