Transcriptional response to vancomycin in a highly resistant mutant Streptomyces coelicolor Fernando Santos-Beneit1, Lorena T. Fernández-Martínez1†, Antonio Rodríguez García1,2, Seomara Martín-Martín1, Ordóñez-Robles2, Paula Yagüe3, Angel Manteca3 and Juan F. Martín2* 1) Institute of Biotechnology of León (INBIOTEC), Avda Real 1, 24006 León (Spain). address: Dept. Molecular Microbiology, John Innes Centre, Norwich, †Current NR4 7UH, U.K. 2) Area of Microbiology, Faculty of Biology and Environmental Sciences, University of León, Campus de Vegazana s/n, 24071 León (Spain). 3) Area of Microbiology, Departamento de Biologia Funcional de IUBA, Faculty of Biology, University of Oviedo, 33006 Oviedo (Spain). Molecular Microbiology Department, John Innes Centre, Colney Lane, NR4 7UH, †) Norwich, UK. Key Words: SCO2594, vancomycin, teicoplanin, phosphate, teichoic Streptomyces, acids *Corresponding author: Juan F. Martín. Email: jf.martin@unileon.es, Tel. +34987291505, Fax: +34987291506
Transcriptional response to vancomycin in a highly Streptomyces coelicolor mutant Fernando Santos-Beneit1, Lorena T. Fernández-Martínez1†, Antonio Rodríguez García1,2, Seomara Martín-Martín1, Ordóñez-Robles2, Paula Yagüe3, Angel Manteca3 and Juan F. Martín2* 1) Institute of Biotechnology of León (INBIOTEC), Avda Real 1, 24006 León (Spain). †Current address: Dept. Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, U.K. 2) Area of Microbiology, Faculty of Biology and Environmental Sciences, University of León, Campus de Vegazana s/n, 24071 León (Spain). 3) Area of Microbiology, Departamento de Biologia Funcional de IUBA, Faculty of Biology, University of Oviedo, 33006 Oviedo (Spain). †) Molecular Microbiology Department, John Innes Centre, Colney Lane, NR4 7UH, Norwich, UK. Key Words: Streptomyces, SCO2594, vancomycin, teicoplanin, phosphate, teichoic acids *Corresponding author: Juan F. Martín. Email: jf.martin@unileon.es, Tel. +34987291505, Fax: +34987291506 resistant