AST> ALT elevated, lactate commercial), disposal of level > mmol/L (36 carcasses and fetuses, mg/dL), DIC not common, assisting with birthing or proteinuria. other animal husbandry activities that resulted in exposure to animal blood and body fluids, or veterinary procedures and necropsies; b) residing in an area where RVF is known to occur or has the potential to occur and recent mosquito bites; or c) consuming unpasteurized milk from RVF-affected areas). Smallpox Smallpox is an 7(12)-17 days Pox virus detected by "A person with acute "A probable case is a A confirmed case is a person with contagious disease caused by any test on any onset of fever suspected case with laboratory evidence of smallpox ≥38.3°C the variola virus, a member specimen type and malaise, and severe either laboratory virus infection by (a. Isolation of of the orthopoxvirus family. prostration with evidence by (a. Detection variola virus and PCR confirmation It was one of the world's headache and backache of a poxvirus resembling of cultured isolate; OR b. most devastating diseases occurring 2 to 4 days variola virus by electron Detection of variola virus by PCR). known to humanity. The last before rash onset AND microscopy; OR b. known natural case was in subsequent development Isolation of variola virus Somalia in 1977. It was of a maculopapular rash pending confirmation; declared eradicated in 1980 starting on the face and OR c. Detection of following a global forearms, then spreading variola virus by nucleic immunization campaign led to the trunk and legs, and acid testing pending by the World Health evolving within 48 hours confirmation); OR Organization. Smallpox is to deep-seated, firm/hard epidemiological linked to transmitted from person to and round confirmed case). person via infective droplets vesicles " during close contact with and later pustules, which infected symptomatic people. may become umbilicated Smallpox has two main or confluent AND forms: variola major and lesions that appear in the variola minor. The two forms same stage of showed similar lesions. The development (i.e. all are disease followed a milder vesicles or all are
AST> ALT elevated, lactate level > mmol/L (36 mg/dL), DIC not common, proteinuria. commercial), disposal of carcasses and fetuses, assisting with birthing or other animal husbandry activities that resulted in exposure to animal blood and body fluids, or veterinary procedures and necropsies; b) residing in an area where RVF is known to occur or has the potential to occur and recent mosquito bites; or c) consuming unpasteurized milk from RVF-affected areas). Smallpox Smallpox is an contagious disease caused by the variola virus, a member of the orthopoxvirus family. It was one of the world's most devastating diseases known to humanity. The last known natural case was in Somalia in 1977. It was declared eradicated in 1980 following a global immunization campaign led by the World Health Organization. Smallpox is transmitted from person to person via infective droplets during close contact with infected symptomatic people. Smallpox has two main forms: variola major and variola minor. The two forms showed similar lesions. The disease followed a milder 7(12)-17 days Pox virus detected by any test on any specimen type "A person with acute onset of fever ≥38.3°C and malaise, and severe prostration with headache and backache occurring 2 to 4 days before rash onset AND subsequent development of a maculopapular rash starting on the face and forearms, then spreading to the trunk and legs, and evolving within 48 hours to deep-seated, firm/hard and round vesicles and later pustules, which may become umbilicated or confluent AND lesions that appear in the same stage of development (i.e. all are vesicles or all are "A probable case is a suspected case with either laboratory evidence by (a. Detection of a poxvirus resembling variola virus by electron microscopy; OR b. Isolation of variola virus pending confirmation; OR c. Detection of variola virus by nucleic acid testing pending confirmation); OR epidemiological linked to confirmed case). " A confirmed case is a person with laboratory evidence of smallpox virus infection by (a. Isolation of variola virus and PCR confirmation of cultured isolate; OR b. Detection of variola virus by PCR).