Table S10. Challenges, potential solutions and suggested actions related to increasing the number and quality of clinical trials in CKD G4+ populations Challenge Potential Suggested action solution The clinical Build the Work with large ISN, needs of CKD health care ASN “business G4+ patients case” for providers that have Kidney are apparent, industry and used such business Health but other other payers cases to justify their Initiative, elements of a to support own CKD G4+ French business case trials in this programs (e.g., CKD trial for conducting population Mayo, Kaiser network trials in this Permanente). Use and population this information to others have not been create a briefing well described document for payers Recruitment Engage Commission and KDIGO, and retention patients to support a group to ISN, ASN to trials is an lead and conduct scoping Kidney ongoing support review and propose Heatlh challenge in clinical trials structures/processes Initiative, CKD G4+ in this to enable sustained French populations population patient engagement CKD clinical trials network Available trials Ensure that Review existing lists KDIGO often do not the findings of patient-centered address the of trials in research priorities needs of CKD CKD G4+ are and commission a G4+ patients maximally new list for CKD and families relevant for G4+ if required patients and families
Table S10. Challenges, potential solutions and suggested actions related to increasing the number and quality of clinical trials in CKD G4+ populations Challenge Potential solution Suggested action The clinical needs of CKD G4+ patients are apparent, but other elements of a business case for conducting trials in this population have not been well described Build the “business case” for industry and other payers to support trials in this population Work with large health care providers that have used such business cases to justify their own CKD G4+ programs (e.g., Mayo, Kaiser Permanente). Use this information to create a briefing document for payers ISN, ASN Kidney Health Initiative, French CKD trial network and others Recruitment and retention to trials is an ongoing challenge in CKD G4+ populations Engage patients to lead and support clinical trials in this population Commission and support a group to conduct scoping review and propose structures/processes to enable sustained patient engagement KDIGO, ISN, ASN Kidney Heatlh Initiative, French CKD clinical trials network Available trials often do not address the needs of CKD G4+ patients and families Ensure that the findings of trials in CKD G4+ are maximally relevant for patients and families Review existing lists of patient-centered research priorities and commission a new list for CKD G4+ if required KDIGO