Table 120 Cheese intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Studies Heterogeneity Author, Number of number of country, Outcome Comparison RR (95%CI) P trend Year studies (I2, p cases area Meta-analyses Aune et al, 7 CRC 1635 North Incidence High vs. low 0.94 (0.75-1.18) - 39%, p=0.14 2012 America, Per 50 g/d 0.96 (0.83-1.12) - 28%, p=0.22 5 CC Europe High vs. low 1.04 (0.69-1.55) - 58%, p=0.05 Per 50 g/d 0.84 (0.68-1.04) - 8.5%, p=0.36 3 RC High vs. low 0.88 (0.59-1.30) - 0%, p=0.84 Per 50 g/d 0.90 (0.70-1.15) - 0%, p=0.93 Ralston et 8 North Incidence High vs. low, 0.94 (0.58-1.54) - 43%, p=0.81 al, 2014 America, men Europe High vs. low, 1.16 (0.82-1.63) - 11%, p=0.41 women High vs. low, all 1.11 (0.90-1.36) - 16%, p=0.34 Pooled analyses Cho et al, 10 CRC 7157 Incidence vs. <5 g/d 1.10 (0.98-1.24) 0.21 NA, p=0.37 ≥25 2004 CC 2912 America, 1.14 (0.95-1.36) 0.38 NA, p=0.10 PCC 1505 Europe 1.21 (1.00-1.45) 0.20 NA, p=0.78 DCC 1238 1.03 (0.84-1.26) 0.94 NA, p=0.61 RC 1208 1.08 (0.86-1.36) 0.28 NA, p=0.31
Table 120 Cheese intake and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p Meta-analyses Aune et al, 2012 7 CRC 5 CC 3 RC 1635 North America, Europe Incidence High vs. low Per 50 g/d High vs. low Per 50 g/d High vs. low Per 50 g/d 0.94 (0.75-1.18) 0.96 (0.83-1.12) 1.04 (0.69-1.55) 0.84 (0.68-1.04) 0.88 (0.59-1.30) 0.90 (0.70-1.15) - - - - - - 39%, p=0.14 28%, p=0.22 58%, p=0.05 8.5%, p=0.36 0%, p=0.84 0%, p=0.93 Ralston et al, 2014 8 North America, Europe Incidence High vs. low, men High vs. low, women High vs. low, all 0.94 (0.58-1.54) 1.16 (0.82-1.63) 1.11 (0.90-1.36) - - - 43%, p=0.81 11%, p=0.41 16%, p=0.34 Pooled analyses Cho et al, 2004 10 CRC CC PCC DCC RC 7157 2912 1505 1238 1208 America, Europe Incidence ≥25 vs. <5 g/d 1.10 (0.98-1.24) 1.14 (0.95-1.36) 1.21 (1.00-1.45) 1.03 (0.84-1.26) 1.08 (0.86-1.36) 0.21 0.38 0.20 0.94 0.28 NA, p=0.37 NA, p=0.10 NA, p=0.78 NA, p=0.61 NA, p=0.31