Quality assessment of patients Effect № Quality Importance of Study a Relative Absolute № Risk of bias Inconsistency Indirectness Imprecision considerations propofol studies design benzodiazepine (95% CI) (95% CI) Mortality 90 day 10 randomised not serious not serious not serious serious a none 95/432 (22.0%) 94/426 (22.1%) RR 1.01 2 more per 1,000 CRITICAL trials (0.79 to 1.29) (from 46 fewer to 64 MODERATE more) Time to Extubation-Hours (assessed with: hours) 16 randomised serious b very serious c not serious not serious none 366 364 - MD 13.71 hours CRITICAL trials lower VERY LOW (20.01 lower to 7.4 lower) Time to Extubation-Hours Sens analysis 10 randomised not serious d very serious e not serious not serious none 211 212 - MD 11.6 lower CRITICAL trials (15.62 lower to 7.58 LOW lower) Time to light sedation 7 randomised not serious serious f not serious serious g none 185 172 - MD 7.23 hours lower CRITICAL trials (8.91 lower to 5.54 LOW lower) Delirium 1 randomised not serious not serious not serious very serious h none 4/14 (28.6%) 5/14 (35.7%) RR 0.80 71 fewer per 1,000 CRITICAL trials (0.27 to 2.37) (from 261 fewer to LOW 489 more)
Quality assessment № of patients Effect Quality Importance № of studies Study design Risk of bias Inconsistency Indirectness Imprecision considerations propofol a benzodiazepine Relative (95% CI) Absolute (95% CI) Mortality 90 day 10 randomised trials not serious not serious not serious serious a none 95/432 (22.0%) 94/426 (22.1%) RR 1.01 (0.79 to 1.29) 2 more per 1,000 (from 46 fewer to 64 more) MODERATE CRITICAL Time to Extubation-Hours (assessed with: hours) 16 randomised trials serious b very serious c not serious not serious none 366 364 - MD 13.71 hours lower (20.01 lower to 7.4 lower) VERY LOW CRITICAL Time to Extubation-Hours Sens analysis 10 randomised trials not serious d very serious e not serious not serious none 211 212 - MD 11.6 lower (15.62 lower to 7.58 lower) LOW CRITICAL Time to light sedation 7 randomised trials not serious serious f not serious serious g none 185 172 - MD 7.23 hours lower (8.91 lower to 5.54 lower) LOW CRITICAL Delirium 1 randomised trials not serious not serious not serious very serious h none 4/14 (28.6%) 5/14 (35.7%) RR 0.80 (0.27 to 2.37) 71 fewer per 1,000 (from 261 fewer to 489 more) LOW CRITICAL