2-12yr (or 12-15yr and <50kg): 9mg/kg 12-hourly Treatment should be initiated with intravenous for 2 doses, then 8mg/kg 12-hourly (reduce in steps regimen. Oral should be considered only after of 1mg/kg if not tolerated, increase in steps of significant clinical improvement 1mg/kg if inadequate response) Voriconazole 2-12yr (or 12-15y and under 50kg): 9mg/kg 12- Serum level monitoring 15-18yr (or 12-15yr and >50kg): 6mg/kg 12-hourly hourly (max 350mg starting dose) available at Bristol. for 2 doses, then 4mg/kg 12-hourly (reduced to (treatment trough/pre- 3mg/kg every 12hrs if not tolerated) 15-18yr (or 12-15yr and over 50kg): 400mg 12- dose 1.0-4.5mg/L) hourly for 2 doses, then 200mg 12-hourly (increased to 300mg if needed) 15-18yr (and under 40kg): 200mg 12-hourly for 2 doses, then 100mg 12-hourly (increased to 150mg if needed) VZIG Intramuscular 0-5yr: 250mg See local guidelines for 6-10yr: 500mg assessment and 11-14yr: 750mg prescription forms to be >15y: 1g completed Baby born to mother with HIV: Baby born to mother with HIV: Prem <30wk: 2 mg/kg 12-hourly for 4 wk Prem: 1.5 mg/kg 12-hourly Term: 1.5 mg/kg 6-hourly Prem 30-34wk: 2 mg/kg 12-hourly for 2wk, then 2 Zidovudine mg/kg 8-hourly for 2wk Term >34wk: 4 mg/kg 12-hourly
Voriconazole Serum level monitoring available at Bristol. (treatment trough/pre- dose 1.0-4.5mg/L) 2-12yr (or 12-15yr and <50kg): 9mg/kg 12-hourly for 2 doses, then 8mg/kg 12-hourly (reduce in steps of 1mg/kg if not tolerated, increase in steps of 1mg/kg if inadequate response) 15-18yr (or 12-15yr and >50kg): 6mg/kg 12-hourly for 2 doses, then 4mg/kg 12-hourly (reduced to 3mg/kg every 12hrs if not tolerated) Treatment should be initiated with intravenous regimen. Oral should be considered only after significant clinical improvement 2-12yr (or 12-15y and under 50kg): 9mg/kg 12- hourly (max 350mg starting dose) 15-18yr (or 12-15yr and over 50kg): 400mg 12- hourly for 2 doses, then 200mg 12-hourly (increased to 300mg if needed) 15-18yr (and under 40kg): 200mg 12-hourly for 2 doses, then 100mg 12-hourly (increased to 150mg if needed) VZIG See local guidelines for assessment and prescription forms to be completed Intramuscular 0-5yr: 250mg 6-10yr: 500mg 11-14yr: 750mg >15y: 1g Zidovudine Baby born to mother with HIV: Prem: 1.5 mg/kg 12-hourly Term: 1.5 mg/kg 6-hourly Baby born to mother with HIV: Prem <30wk: 2 mg/kg 12-hourly for 4 wk Prem 30-34wk: 2 mg/kg 12-hourly for 2wk, then 2 mg/kg 8-hourly for 2wk Term >34wk: 4 mg/kg 12-hourly