in healthy controls (p=0.011), although refractory epilepsy controls had the lowest volume (p<0.0005). Linear regressions comparing the thalamic and brain volumes between the groups. Element in the linear regression model Coefficient with 95%CI p-value LEFT+RIGHT THALAMUS Left+right Intercept (11.83942 - 14.75345) <0.0005 thalami Group [0 cases, 1 healthy controls] 1.155137 (0.2786866 - 2.031588) 0.011 ESES patients Age [years] 0.1517549 (0.0132935 - 0.2902163) 0.032 versus healthy controls Left+right Intercept 12.49911 (10.86957 - 14.12865) <0.0005 thalami Group [0 cases, 1 refractory epilepsy] - 0.2199336 (-1.132145 - 0.6922781) 0.629 ESES patients Age [years] 0.2399167 (0.0779831 - 0.4018502) 0.005 versus refractory epilepsy controls Left+right Intercept (11.3562 - 13.64691) <0.0005 1.326184 (0.6179078 - 2.034459) <0.0005 thalami [0 refractory, 1 healthy control] 0.2141382 (0.097735 - 0.3305414) <0.0005 Refractory Age [years] epilepsy controls versus healthy controls Supplementary Figure 4. Graphic representation of volumes (y axis) over age (x volume). Left+right thalamic volume. Individual observations are represented as circles with their respective best fit curves. Green: ESES patients. Blue: Healthy controls. Red: Refractory epilepsy controls. We calculated the Relative thalamic volumes ( Supplementary Figures 5 and 6). percentage of the brain volume occupied by the thalamus. Relative thalamic volumes were no different between the groups. Relative thalamic volumes. Relative volume of the left+right thalamus rank test
in healthy controls (p=0.011), although refractory epilepsy controls had the lowest volume (p<0.0005). Linear regressions comparing the thalamic and brain volumes between the groups. Element in the linear regression model Coefficient with 95%CI p-value LEFT+RIGHT THALAMUS Left+right thalami ESES patients versus healthy controls Intercept Group [0 cases, 1 healthy controls] Age [years] (11.83942 - 14.75345) 1.155137 (0.2786866 - 2.031588) 0.1517549 (0.0132935 - 0.2902163) <0.0005 0.011 0.032 Left+right thalami ESES patients versus refractory epilepsy controls Intercept Group [0 cases, 1 refractory epilepsy] Age [years] 12.49911 (10.86957 - 14.12865) - 0.2199336 (-1.132145 - 0.6922781) 0.2399167 (0.0779831 - 0.4018502) <0.0005 0.629 0.005 Left+right thalami Refractory epilepsy controls versus healthy controls Intercept [0 refractory, 1 healthy control] Age [years] (11.3562 - 13.64691) 1.326184 (0.6179078 - 2.034459) 0.2141382 (0.097735 - 0.3305414) <0.0005 <0.0005 <0.0005 Supplementary Figure 4. Graphic representation of volumes (y axis) over age (x volume). Left+right thalamic volume. Individual observations are represented as circles with their respective best fit curves. Green: ESES patients. Blue: Healthy controls. Red: Refractory epilepsy controls. Relative thalamic volumes ( Supplementary Figures 5 and 6). We calculated the percentage of the brain volume occupied by the thalamus. Relative thalamic volumes were no different between the groups. Relative thalamic volumes. Relative volume of the left+right thalamus rank test