Table 322 BMI and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analyses (years) Vlaardingen cohort study, Mid-point Taghizadeh, Prospective 113/ categories 2015 National death Data obtained Mortality, obese vs normal Age, residence, Cohort, 8 645 1.28 (0.73-2.25) COL41055 certificate from the survey colorectal cancer kg/m2 smoking Age: 20-65 40 years Person-years of Netherlands years, follow up M/W per 5 kg/m2 1.10 (1.07-1.13) 13 465/ Incidence, Mid-point 5 243 978 35 vs 18.5-24.9 cancer CPRD, Age, sex, categories 1.36 (1.23-1.51) 25 years kg/m2 Bhaskaran, 2014 Prospective Weight and diabetes, COL41010 Cohort, Medical records height were status, Hamling method 6 123/ per 5 kg/m2 1.04 (1.00-1.08) Incidence, rectal UK Age: 16- years, measured alcohol, used to 35 vs 18.5-24.9 cancer M/W calendar year recalculate the 1.18 (1.01-1.38) 5 819/ kg/m2 RR’s Never smokers per 5 kg/m2 1.05 (0.99-1.12)
Table 322 BMI and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analyses Taghizadeh, 2015 COL41055 Netherlands Vlaardingen cohort study, Prospective Cohort, Age: 20-65 years, M/W 113/ 8 645 40 years National death certificate Data obtained from the survey Mortality, colorectal cancer obese vs normal kg/m2 1.28 (0.73-2.25) Age, residence, smoking Mid-point categories Person-years of follow up Bhaskaran, 2014 COL41010 UK CPRD, Prospective Cohort, Age: 16- years, M/W 13 465/ 5 243 978 25 years Medical records Weight and height were measured Incidence, cancer per 5 kg/m2 1.10 (1.07-1.13) Age, sex, diabetes, status, alcohol, calendar year Mid-point categories Hamling method used to recalculate the RR’s 35 vs 18.5-24.9 kg/m2 1.36 (1.23-1.51) 6 123/ Incidence, rectal cancer per 5 kg/m2 1.04 (1.00-1.08) 5 819/ 35 vs 18.5-24.9 kg/m2 1.18 (1.01-1.38) Never smokers per 5 kg/m2 1.05 (0.99-1.12)