ASD= autism spectrum disorders; y= years of age Table 9. Tissue Studies that Examine Susceptibility to Mercury (or environmental toxins”) in ASD “pro-oxidant Body Authors and N Purpose of Study Findings Tissue/Substance Journal Age LCLs Rose et al. [79] ASD 16 Human LCL in autism vs. Autism LCLs J Toxicol Controls 16 controls exposed to TM exhibited greater reduction in ASD 5-13 y respiration, Controls 5-37 y maximal respiratory capacity, and reserve capacity, compared to control LCLs exposed to TM LCLs Rose et al. [80] ASD 22 Human LCL in autism and Depletion of Transl Controls 14 mitochondrial reserve reserve capacity Psychiatry capacity making them more ASD mean 7.8 y vulnerable to Controls mean 27.7 y environmental toxins LCLs James et al. ASD 10 LCLs derived from autistic TM resulted in [81] Controls 10 children and controls, greater decrease in GSH/GSSG ratio
ASD= autism spectrum disorders; y= years of age Table 9. Tissue Studies that Examine Susceptibility to Mercury (or “pro-oxidant environmental toxins”) in ASD Body Tissue/Substance Authors and Journal N Age Purpose of Study Findings LCLs Rose et al. [79] J Toxicol ASD 16 Controls 16 ASD 5-13 y Controls 5-37 y Human LCL in autism vs. controls exposed to TM Autism LCLs exhibited greater reduction in respiration, maximal respiratory capacity, and reserve capacity, compared to control LCLs exposed to TM LCLs Rose et al. [80] Transl Psychiatry ASD 22 Controls 14 ASD mean 7.8 y Controls mean 27.7 y Human LCL in autism and mitochondrial reserve capacity Depletion of reserve capacity making them more vulnerable to environmental toxins LCLs James et al. [81] ASD 10 Controls 10 LCLs derived from autistic children and controls, TM resulted in greater decrease in GSH/GSSG ratio