Table S6: Level of total 1,2-unstaurated PAs in (herbal) teas and corresponding EDI values assuming use of one cup of (herbal) tea per day, resulting MOE values calculated using the BMDL10 for lasiocarpine of 0.07 mg/kg bw/day and BMDL10 of riddelliine (0.18 mg/kg bw/day) respectively. Data for PA levels were taken from the EFSA report (2016). Type of herbal tea No. Mean PA conc. EDI MOE based on MOE based on 95th Percentile EDI MOE on MOE based on (µg/kg) (µg/kg bw/day) lasiocarpine riddelliine PA conc. (µg/kg) (µg/kg bw/day) lasiocarpine riddelliine Tea and herbs for 1002 135 0.004 18100 46700 405 0.01 6050 15600 infusions, unspecified Tea unspecified 14 67.5 0.002 36300 ― ― ― ― Tea unspecified, 12 15 0.0004 163000 420000 ― ― ― ― decaffeinated Black 339 120 0.003 52500 570 0.02 4300 Green 310 60 0.002 40800 105000 277.5 0.008 8830 Camomile flowers 256 172.5 0.005 14200 36500 735 0.02 3300 8600 Peppermint 196 262.5 0.008 9300 24000 765 0.02 3200 8200 Rooibos 167 307.5 0.009 7967 20500 772.5 0.02 3200 8200 Yerba mate 167 30 0.0009 81700 200000 ― ― ― ― Tea for infants and 39 45 0.001 54400 140000 ― ― ― ― children Cannot be calculated because the PA levels were not provided or < LOQ. ―
Table S6: Level of total 1,2-unstaurated PAs in (herbal) teas and corresponding EDI values assuming use of one cup of (herbal) tea per day, resulting MOE values calculated using the BMDL10 for lasiocarpine of 0.07 mg/kg bw/day and BMDL10 of riddelliine (0.18 mg/kg bw/day) respectively. Data for PA levels were taken from the EFSA report (2016). Type of herbal tea No. Mean PA conc. (µg/kg) EDI (µg/kg bw/day) MOE based on lasiocarpine MOE based on riddelliine 95th Percentile PA conc. (µg/kg) EDI (µg/kg bw/day) MOE on lasiocarpine MOE based on riddelliine Tea and herbs for infusions, unspecified 1002 135 0.004 18100 46700 405 0.01 6050 15600 Tea unspecified 14 67.5 0.002 36300 ― ― ― ― Tea unspecified, decaffeinated 12 15 0.0004 163000 420000 ― ― ― ― Black 339 120 0.003 52500 570 0.02 4300 Green 310 60 0.002 40800 105000 277.5 0.008 8830 Camomile flowers 256 172.5 0.005 14200 36500 735 0.02 3300 8600 Peppermint 196 262.5 0.008 9300 24000 765 0.02 3200 8200 Rooibos 167 307.5 0.009 7967 20500 772.5 0.02 3200 8200 Yerba mate 167 30 0.0009 81700 200000 ― ― ― ― Tea for infants and children 39 45 0.001 54400 140000 ― ― ― ― ― Cannot be calculated because the PA levels were not provided or < LOQ.