Extension Student modelling of the double circulatory system mark out the – classroom to have a double circulation with the heart in the centre and desks for other organs. Students have to pick up oxygen, carbon dioxide, glucose and urea cards at key points and drop them at the correct points where they leave the blood. Time Learning activity with opportunity Assessment Learning Outcome Resources Learning objective taken to develop skills opportunities The quaternary structure 0.4 Relate knowledge Learning activities: Past exam paper of haemoglobins. weeks of protein structure material: use RASMOL/information to the structure of The role of haemoglobin sheets to investigate the June 2013 Q6 – haemoglobin. in the loading, transport structure of haemoglobin. Ask BIOL2 Jan 2012 Q9a Explain what is – and unloading of Rich questions: students to relate this back to meant by the term oxygen. BIOL2 June 2010 protein structure from 3.1.4 – Why does pressure”. “partial Q7a teacher introduction to the The cooperative nature haemoglobin have Explain how the dual role of loading in the of oxygen binding, with BIOL2 June 2010 Q9 a quaternary binding of one – lungs and unloading in the the binding of the first (except 9c) structure? oxygen molecule respiring tissues (using oxygen molecule making What effect does changes the shape animations) the binding of the first oxygen of haemoglobin and teacher explanation of the subsequent oxygen binding have on the how this affects the oxyhaemoglobin dissociation molecules easier. structure of binding of further curve, the concept of partial haemoglobin? oxygen molecules.
Extension Student modelling of the double circulatory system – mark out the classroom to have a double circulation with the heart in the centre and desks for other organs. Students have to pick up oxygen, carbon dioxide, glucose and urea cards at key points and drop them at the correct points where they leave the blood. Learning objective Time taken Learning Outcome Learning activity with opportunity to develop skills Assessment opportunities Resources The quaternary structure of haemoglobins. The role of haemoglobin in the loading, transport and unloading of oxygen. The cooperative nature of oxygen binding, with the binding of the first oxygen molecule making the binding of subsequent oxygen molecules easier. 0.4 weeks Relate knowledge of protein structure to the structure of haemoglobin. Explain what is meant by the term “partial pressure”. Explain how the binding of one oxygen molecule changes the shape of haemoglobin and how this affects the binding of further oxygen molecules. Learning activities: use RASMOL/information sheets to investigate the structure of haemoglobin. Ask students to relate this back to protein structure from 3.1.4 teacher introduction to the dual role of loading in the lungs and unloading in the respiring tissues (using animations) teacher explanation of the oxyhaemoglobin dissociation curve, the concept of partial Past exam paper material: June 2013 – Q6 BIOL2 Jan 2012 – Q9a BIOL2 June 2010 – Q7a BIOL2 June 2010 – Q9 (except 9c) Rich questions: Why does haemoglobin have a quaternary structure? What effect does the first oxygen binding have on the structure of haemoglobin?