500 ppm: M 55.1 69.0 F 83.9 89.0 n = 25/sex/dose/generation Rat Wistar M & F Diet (ad Test material: 99% purity methiocarb Feed Conclusions: Eiben, R. (2003d) ≥ libitum) and in CrIGIxBrlHan: NOAEL parental toxicity = 50 ppm: 31-March-2003 milk during Wl non-weaned Estimated mean daily active-intake/ Altromin® M = 4.6 & F= 6.9 (Study No.: T 7071 667 period for animal of F0 & F1(mg/kg bw/d), per 1321 meal + [LOAEL = 150 ppm: based on AChE Report-No: AT0341 pups treatment: 1% peanut F0 animals: activity] oil (DAB 10) Document No.: AT00341 F0 F1 13–15 wk / 0 ppm: MO-03-004371 M & F 0 0 F0 animals: Record No.: 50 ppm: Weight not M-088195-01-1 / M 4.6 U* recorded MO-03-004371) F 6.9 U 150 ppm: M 14.8 U F 21.3 U 500 ppm: M 55.1 U F 83.9 U
500 ppm: M 55.1 69.0 F 83.9 89.0 n = 25/sex/dose/generation Rat Wistar CrIGIxBrlHan: Wl F0 animals: 13–15 wk F0 animals: Weight not recorded M & F Diet (ad libitum) and in milk during non-weaned period for pups Test material: ≥ 99% purity methiocarb Estimated mean daily active-intake/ animal of F0 & F1(mg/kg bw/d), per treatment: F0 F1 0 ppm: M & F 0 0 50 ppm: M 4.6 U* F 6.9 U 150 ppm: M 14.8 U F 21.3 U 500 ppm: M 55.1 U F 83.9 U Feed Altromin® 1321 meal + 1% peanut oil (DAB 10) Conclusions: NOAEL parental toxicity = 50 ppm: M = 4.6 & F= 6.9 [LOAEL = 150 ppm: based on AChE activity] Eiben, R. (2003d) 31-March-2003 (Study No.: T 7071 667 Report-No: AT0341 Document No.: AT00341 / MO-03-004371 Record No.: M-088195-01-1 / MO-03-004371)