Table 274 Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis. Cases/ Author, Year, name, Study size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Age, sex, GEOL, number of Prospective Jung, 2014 122/ 0.98 (0.59-1.62) colonoscopies Cohort, colonoscopy Incidence, > 2 vs 1.75 ≤ COL41011 470 FFQ MMR mutation during Genotyping data Age: 18-20 examination colorectal cancer mg/day Netherlands 28 months carriers time, NSAID years, use, and M/W physical activity NHS-HPFS Used in HvsL Prospective Nishahara, 2014 993/ medical records analysis only Cohort, Incidence, COL41036 3 206 985 and national FFQ Q5 vs Q1 0.98 (0.74-1.31) Age, year, sex Age: 30-75 colorectal cancer USA person-years death index No specific years, quintiles M/W 0.68 (0.51-0.91) MTHFR CC MEC, Age at blood 0.87 (0.64-1.20) Le Marchand, 822 cases/ Incidence, 2.46 vs 1.63 Nested FFQ draw, sex, Genotype data 2005 2 021 controls colorectal cancer mg/day study race/ethnicity CT 0.53 (0.32-0.86) TT
time, Table 274 Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis. Author, Year, WCRF Code, Country name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Jung, 2014 COL41011 Netherlands GEOL, Prospective Cohort, Age: 18-20 years, M/W 122/ 470 28 months colonoscopy examination FFQ Incidence, colorectal cancer > 2 vs ≤ 1.75 mg/day 0.98 (0.59-1.62) MMR mutation carriers Age, sex, number of colonoscopies during NSAID use, and physical activity Genotyping data Nishahara, 2014 COL41036 USA NHS-HPFS Prospective Cohort, Age: 30-75 years, M/W 993/ 3 206 985 person-years medical records and national death index FFQ Incidence, colorectal cancer Q5 vs Q1 0.98 (0.74-1.31) Age, year, sex Used in HvsL analysis only No specific quintiles Le Marchand, 2005 MEC, Nested study 822 cases/ 2 021 controls FFQ Incidence, colorectal cancer 2.46 vs 1.63 mg/day 0.68 (0.51-0.91) MTHFR CC Age at blood draw, sex, race/ethnicity Genotype data 0.87 (0.64-1.20) CT 0.53 (0.32-0.86) TT