217 Alcohol (as ethanol) and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Number of Total Studies Heterogeneity Author, Year cohort number of Outcome Comparison RR (95%CI) P country, area (I2, p studies cases Pooled analyses Colorectal Men 1.24(0.69-2.22) 0.97 579 vs 0 g/day ≥45 cancer Women 1.52(0.56-4.10) 0.72 380 cancer 1.21(0.77-1.90) 0.85 Park, 2010 7 UK 174 Proximal 1.03 (0.57-1.86) 0.54 vs <5 g/day ≥30 146 Distal colon 1.60 (0.85-3.01) 0.46 199 Rectal cancer 0.93(0.48-1.78) 0.76 M 1724 Colorectal Men 1.11 (1.09-1.14) <0.001 W 1078 cancer Women 1.13 (1.06-1.20) <0.001 5 M 1093 Men 1.12 (1.09-1.15) <0.001 Mizoue, 2008 Japan Per 15g/day Colon cancer W 736 Women 1.14 (1.05-1.23) 0.001 M 629 Men 1.11 (1.07-1.15) <0.001 Rectal cancer W 338 1.14 (1.02-1.29) 0.027
217 Alcohol (as ethanol) and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P Heterogeneity (I2, p Pooled analyses Park, 2010 7 579 UK Colorectal cancer ≥45 vs 0 g/day Men 1.24(0.69-2.22) Women 1.52(0.56-4.10) 0.97 0.72 380 cancer ≥30 vs <5 g/day 1.21(0.77-1.90) 0.85 174 Proximal 1.03 (0.57-1.86) 0.54 146 Distal colon 1.60 (0.85-3.01) 0.46 199 Rectal cancer 0.93(0.48-1.78) 0.76 Mizoue, 2008 5 M 1724 W 1078 Japan Colorectal cancer Per 15g/day Men 1.11 (1.09-1.14) Women 1.13 (1.06-1.20) <0.001 <0.001 M 1093 W 736 Colon cancer Men 1.12 (1.09-1.15) Women 1.14 (1.05-1.23) <0.001 0.001 M 629 W 338 Rectal cancer Men 1.11 (1.07-1.15) 1.14 (1.02-1.29) <0.001 0.027