Due to a downgrade for serious imprecision Diastolic blood pressure (follow up: median 4 weeks) randomized trials not serious not serious not serious serioush none -1.36 mmHg (-2.33, -0.38) Due to a downgrade 7 N=439 for serious imprecision CRP (follow up: median 4 randomized trials not serious not serious not serious seriousi none -0.58 mg/L (-1.01, -0.15) Due to a downgrade 7 N=435 for serious imprecision 10-year CHD risk (follow up: median 4 weeks) MODERATE randomized trials not serious not seriousj not serious seriousk none -1.34% (-2.19, -0.49) Due to a downgrade 5 N=415 for serious imprecision Body weight (follow up: median 4 weeks) ⨁⨁⨁⨁ randomized trials not serious not serious not serious not seriousl none -0.10kg (-0.48, 0.27) 7 HIGH N=439 Apo-B, Apolipoprotein-B; CI, Confidence interval; CRP, c-reactive protein; CHD, coronary heart disease; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; MD, Mean difference; Total-C, total cholesterol. a We did not downgrade for serious inconsistency, since all of the heterogeneity in the analysis was explained when the one effectiveness study by Jenkins et al. 2011 (Jenkins et al. 2011-routine and Jenkins et al. 2011-intensive) was removed as part of sensitivity analyses (Original: I2=52%, P-heterogeneity=0.05; a priori after study removed: I2=0%, P-heterogeneity=0.77).
Due to a downgrade for serious imprecision Diastolic blood pressure (follow up: median 4 weeks) 7 N=439 randomized trials not serious not serious not serious serioush none -1.36 mmHg (-2.33, -0.38) Due to a downgrade for serious imprecision CRP (follow up: median 4 7 N=435 randomized trials not serious not serious not serious seriousi none -0.58 mg/L (-1.01, -0.15) Due to a downgrade for serious imprecision 10-year CHD risk (follow up: median 4 weeks) 5 N=415 randomized trials not serious not seriousj not serious seriousk none -1.34% (-2.19, -0.49) MODERATE Due to a downgrade for serious imprecision Body weight (follow up: median 4 weeks) 7 N=439 randomized trials not serious not serious not serious not seriousl none -0.10kg (-0.48, 0.27) ⨁⨁⨁⨁ HIGH Apo-B, Apolipoprotein-B; CI, Confidence interval; CRP, c-reactive protein; CHD, coronary heart disease; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; MD, Mean difference; Total-C, total cholesterol. a We did not downgrade for serious inconsistency, since all of the heterogeneity in the analysis was explained when the one effectiveness study by Jenkins et al. 2011 (Jenkins et al. 2011-routine and Jenkins et al. 2011-intensive) was removed as part of a priori sensitivity analyses (Original: I2=52%, P-heterogeneity=0.05; after study removed: I2=0%, P-heterogeneity=0.77).