Vasopressor Shehabi 2013 [6] Inconclusive Steroid Schreiber 2014 [25] Schreiber 2014 [25] Inconclusive Hsieh 2014 [21] Wolters 2015 [44] (Analgo)sedation Colombo 2012 [11] Shehabi 2013 [6] Inconclusive Simons 2014 [13] Bryczkowski 2014 [10] Psychoactive medication van Rompaey 2009 [29] Pandharipande 2006 Moderate Mehta 2015 [24] [3] Pisani 2009 [45] Anticholinergic drugs Pandharipande 2006 Inconclusive [3] H2 blokker Pandharipande 2008 Inconclusive [43] Propofol Moderate Hsieh 2014 [21] Pandharipande 2006 [3] Seymour 2012 [40] Svenningsen 2013 [42] Paired sedation and Girard 2008 [46] Inconclusive ventilator weaning protocol vs sedation per usual care plus daily ventilator weaning Received sedative infusion Kamdar 2015 [18] Inconclusive while not mechanically ventilated Received sedative infusion Kamdar 2015 [18] Inconclusive mechanically ventilated Anesthetics Pandharipande 2008 Inconclusive [43] Epidural analgesia Dubois 2001 [47] Yoshitaka 2013 [8] Inconclusive Other medication: Emergency admission [14] Inconclusive Zaal 2012 Melatonin Yoshitaka 2013 [8] Inconclusive Uses pharmacological Kamdar 2015 [18] Inconclusive aids at home
Vasopressor Shehabi 2013 [6] Inconclusive Steroid Schreiber 2014 [25] Schreiber 2014 [25] Hsieh 2014 [21] Wolters 2015 [44] Inconclusive (Analgo)sedation Colombo 2012 [11] Simons 2014 [13] Shehabi 2013 [6] Bryczkowski 2014 [10] Inconclusive Psychoactive medication van Rompaey 2009 [29] Mehta 2015 [24] Pisani 2009 [45] Pandharipande 2006 [3] Moderate Anticholinergic drugs Pandharipande 2006 [3] Inconclusive H2 blokker Pandharipande 2008 [43] Inconclusive Propofol Hsieh 2014 [21] Pandharipande 2006 [3] Seymour 2012 [40] Svenningsen 2013 [42] Moderate Paired sedation and ventilator weaning protocol vs sedation per usual care plus daily ventilator weaning Girard 2008 [46] Inconclusive Received sedative infusion while not mechanically ventilated Kamdar 2015 [18] Inconclusive Received sedative infusion mechanically ventilated Kamdar 2015 [18] Inconclusive Anesthetics Pandharipande 2008 [43] Inconclusive Epidural analgesia Dubois 2001 [47] Yoshitaka 2013 [8] Inconclusive Other medication: Emergency admission Zaal 2012 [14] Inconclusive Melatonin Yoshitaka 2013 [8] Inconclusive Uses pharmacological aids at home Kamdar 2015 [18] Inconclusive