nephritic factor) Progeroid and Autoinflammatory disorders Subtype Skin & Muscle Kidney Nervous GI GU Other ↓Fat ↑Fat Appendages Bone Liver Endocrine Mineral Spleen Ogival palate Skin dimpling Abnormal & mottling dentition Sclerotic skin EKG & Echo Mild Dysmorphic facies Almost all Stooped shoulders AD changes abnormalities IR Aged appearance fat lost Acroosteolysis Pubertal delay HGPS de <1 Prominent Angina Mild TIA Growth failure None Coxa valga N N Mammary (LMNA) year cutaneous HTN Stroke Short stature Osteoporosis aplasia vasculature Premature voice fat spared) Subluxed finger Alopecia athero-sclerosis Death in 2nd ↑TG joints Dysplastic Joint stiffness nails mass ↓muscle Pigmentary skin changes Mandibular Valvular Dysmorphic facies Type A Upper and Face Alopecia hypoplasia calcification IR/DM Aged appearance MAD AR Lower Neck Soft tissue Acroosteolysis N N N N Premature Growth failure ↑TG (LMNA) limbs calcinosis Dental crowding athero-sclerosis Short stature Hypoplastic
nephritic factor) Progeroid and Autoinflammatory disorders Subtype ↓Fat ↑Fat Skin & Appendages Muscle Bone Mineral Kidney Nervous GI Liver Spleen GU Endocrine Other HGPS (LMNA) AD de <1 year Almost all fat lost fat spared) None Skin dimpling & mottling Sclerotic skin changes Prominent cutaneous vasculature Alopecia Dysplastic nails Ogival palate Abnormal dentition Stooped shoulders Acroosteolysis Coxa valga Osteoporosis Subluxed finger joints Joint stiffness ↓muscle mass EKG & Echo abnormalities Angina HTN Premature athero-sclerosis Mild IR Mild ↑TG N TIA Stroke N Pubertal delay Mammary aplasia Dysmorphic facies Aged appearance Growth failure Short stature voice Death in 2nd Type A MAD (LMNA) AR Upper and Lower limbs Face Neck Pigmentary skin changes Alopecia Soft tissue calcinosis Mandibular hypoplasia Acroosteolysis Dental crowding Hypoplastic Valvular calcification Premature athero-sclerosis IR/DM ↑TG N N N N Dysmorphic facies Aged appearance Growth failure Short stature