Table S- 4. Goodness-of-Fit P-Values for Selected Models; Data Sets Considered Separately Data Set Model 1-gen 2-gen-1 2-gen-2 NLN 0.13 0.10 0.18 NCTR 0.11 0.11 0.18 Table S-5. Likelihood Ratio Test Results for Data Set Combinations Data Set Combinations 1-gen + 1-gen + 2-gen-1 + Model All 3 2-gen-1 2-gen-2 2-gen-2 #param #param #param NLN Modeled -811.753 17 -752.903 17 -1062.93 16 -1313.8 25 separately NCTR -811.739 17 -752.893 17 -1062.94 16 -1313.79 25 NLN Modeled -814.732 13 -755.037 13 -1066.72 8 -1320.08 13 together NCTR -814.72 13 -754.937 13 -1066.72 8 -1320.08 13 chi-sq df chi-sq df chi-sq df chi-sq df Testing for 5.958 4 4.268 4 7.572 8 12.57 12 NLN Suitability p-value = 0.20 0.37 0.48 0.40 for 5.962 4 4.088 4 7.564 8 12.59 12 NCTR Combining p-value = 0.20 0.39 0.48 0.40 For combinations including the 1-generation study, the 10 mg/kg-day dose was entered as 10.00001 mg/kg-day so that that 10 mg/kg-day group would be treated separately (have a separate IC estimate) from the 10 mg/kg-day groups from the 2-generation study. Table S-6. Goodness-of-Fit P-values for Data Set Combinations Data Set Combinations: GoF p-values Model 1-gen + 1-gen + 2-gen-1 + All 3 2-gen-1 2-gen-2 2-gen-2 NLN 0.08 0.11 0.03 0.02 NCTR 0.08 0.11 0.03 0.02
Table S- 4. Goodness-of-Fit P-Values for Selected Models; Data Sets Considered Separately Model Data Set 1-gen 2-gen-1 2-gen-2 NLN 0.13 0.10 0.18 NCTR 0.11 0.11 0.18 Table S-5. Likelihood Ratio Test Results for Data Set Combinations Model Data Set Combinations 1-gen + 2-gen-1 1-gen + 2-gen-2 2-gen-1 + 2-gen-2 All 3 #param #param #param Modeled separately NLN -811.753 17 -752.903 17 -1062.93 16 -1313.8 25 NCTR -811.739 17 -752.893 17 -1062.94 16 -1313.79 25 Modeled together NLN -814.732 13 -755.037 13 -1066.72 8 -1320.08 13 NCTR -814.72 13 -754.937 13 -1066.72 8 -1320.08 13 chi-sq df chi-sq df chi-sq df chi-sq df Testing for Suitability for Combining NLN 5.958 4 4.268 4 7.572 8 12.57 12 p-value = 0.20 0.37 0.48 0.40 NCTR 5.962 4 4.088 4 7.564 8 12.59 12 p-value = 0.20 0.39 0.48 0.40 For combinations including the 1-generation study, the 10 mg/kg-day dose was entered as 10.00001 mg/kg-day so that that 10 mg/kg-day group would be treated separately (have a separate IC estimate) from the 10 mg/kg-day groups from the 2-generation study. Table S-6. Goodness-of-Fit P-values for Data Set Combinations Model Data Set Combinations: GoF p-values 1-gen + 2-gen-1 1-gen + 2-gen-2 2-gen-1 + 2-gen-2 All 3 NLN 0.08 0.11 0.03 0.02 NCTR 0.08 0.11 0.03 0.02