Auestad et al. 0.45 0.14 82/77/162 12 DHA+ARA formula maintained Quality - Groups comparable at (2001) DHA and ARA blood levels baseline; selection and similar to BF and higher than C allocation procedures DB RCT (P<.01). described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations high drop-out – rate (27%) Overall moderate-high – quality Ben et al. NR NR 26/52/69 6 DHA+ARA formula group had Quality Groups comparable at – (2004) plasma DHA & ARA levels that baseline; appropriate were: outcomes, outcomes reliably RCT higher than control at 3 and 6 mo. measured. – similar to BF at 3 mo and higher Limitations Limited description – – than BF at mo of selection and allocation procedures described; blood measures not main outcome of study; disposition of subjects not provided; no power calculation provided. Overall limited quality –
Auestad et al. (2001) DB RCT 0.45 0.14 82/77/162 12 DHA+ARA formula maintained DHA and ARA blood levels similar to BF and higher than C (P<.01). Quality - Groups comparable at baseline; selection and allocation procedures described; disposition of subjects provided; appropriate outcomes, outcomes reliably measured; adequate statistical power, large study population. Limitations – high drop-out rate (27%) Overall – moderate-high quality Ben et al. (2004) RCT NR NR 26/52/69 6 DHA+ARA formula group had plasma DHA & ARA levels that were: – higher than control at 3 and 6 mo. – similar to BF at 3 mo and higher than BF at mo Quality – Groups comparable at baseline; appropriate outcomes, outcomes reliably measured. Limitations – Limited description of selection and allocation procedures described; blood measures not main outcome of study; disposition of subjects not provided; no power calculation provided. Overall – limited quality