exposure category. Mid- of exposure categories. Intakes in g/1000kcal/day converted to g/day using average energy intake per each quantile Age, alcohol Incidence, per 1 intake, aspirin colorectal 1.08 (0.97-1.21) serving/day use, BMI, Conversion 1 cancer, men NHS+HPFS, colonoscopy, serving/day to Fung, 2010 Self report Prospective energy, family 100g/day, used COL40828 verified by FFQ Cohort, history, history only in USA 132 746 medical record per 1 M/W of polyps, response Women 1.12 (0.99-1.26) serving/day physical analysis. activity, smoking Age, alcohol 617/ Incidence, vs ≥40.3 ≤14.24 intake, BMI, 48 666 1.12 (0.86-1.46) Distribution of colorectal cancer g/day CBSS, Record linkages educational 16.4 years person-years by Prospective to cancer level, fat intake, 2007 exposure Incidence, colon vs ≥40.3 ≤14.24 Cohort, database and to fibre, folic acid, 428/ 0.88 (0.64-1.21) COL40637 FFQ category. Mid- cancer g/day Age: 40-59 the national HRT use, Canada of years, mortality menopausal exposure W database status, oral Incidence, rectal vs ≥40.3 ≤14.24 categories. 195/ 1.95 (1.21-3.16) contraceptive cancer g/day use, pack-years
exposure category. of exposure categories. Intakes in g/1000kcal/day converted to g/day using average energy intake per each quantile Fung, 2010 COL40828 USA NHS+HPFS, Prospective Cohort, M/W 132 746 Self report verified by medical record FFQ Incidence, colorectal cancer, men per 1 serving/day 1.08 (0.97-1.21) Age, alcohol intake, aspirin use, BMI, colonoscopy, energy, family history, history of polyps, physical activity, smoking Conversion 1 serving/day to 100g/day, used only in analysis. Women per 1 serving/day 1.12 (0.99-1.26) 2007 COL40637 Canada CBSS, Prospective Cohort, Age: 40-59 years, W 617/ 48 666 16.4 years Record linkages to cancer database and to the national mortality database FFQ Incidence, colorectal cancer ≥40.3 vs ≤14.24 g/day 1.12 (0.86-1.46) Age, alcohol intake, BMI, educational level, fat intake, fibre, folic acid, HRT use, menopausal status, oral contraceptive use, pack-years Distribution of person-years by exposure category. of exposure categories. 428/ Incidence, colon cancer ≥40.3 vs ≤14.24 g/day 0.88 (0.64-1.21) 195/ Incidence, rectal cancer ≥40.3 vs ≤14.24 g/day 1.95 (1.21-3.16) response Mid- Mid-