Worst Eye DME Count Frequency Clinically significant DME 29 0.035 (‘fundus’) Center-involved DME 19 0.023 (‘OCT’) Clinically significant DME AND/OR 42 0.051 Center involved DME Supplemental Table 1b Supplemental Table 1. Prevalence of Diabetic Retinopathy in the study by 1a) ETDRS severity level of the worst eye; 1b) DME level of the worst eye. Frequencies are calculated based on the subset of 819 analyzable participants. Worst ETDRS Fundus-based Level Description Clinically Significant Macular Fundus based classification Edema 10 No or Mild NPDR absent mtmDR- 12, 14A, 14B, Mild NPDR 14C,14Z, 15, 20 a) zone of retinal thickening > 1 disc 10 No or Mild NPDR area, part < 1 disc diameter from foveal center mtmDR+ 12, 14A, 14B, Mild NPDR b) retinal thickening or adjacent hard 14C, 14Z, 15, 20 exudates < 600µm from foveal center 35A, 35B, 35C, 35D, 35E, 35F, Moderate NPDR absent or present mtmDR+ 43A, 43B, 47A, 47B, 47C, 47D 53A, 53B, 53C, Severe NPDR 53D, 53E 60, 61A, 61B, mtmDR+ 65A, 65B, 65C, absent or present vtDR+ 71A, 71B, 71C, PDR 71D, 75, 81, 85A, 85B Supplemental Table 2. Mapping of Early Treatment of Diabetic Retinopathy Study (ETDRS) severity levels (worst eye) and combination with fundus based Diabetic Macular Edema (DME) to the dichotomous categories (no or mild NPDR and no DME), fundus mtmDR – + (more than moderate DR: more than mild DR or DME), as well as fundus mtmDR vtDR+ (vision threatening DR: severe NPDR, or PDR, or DME). NPDR = Non Proliferative DR.
Worst Eye DME Count Frequency Clinically significant DME (‘fundus’) 29 0.035 Center-involved DME (‘OCT’) 19 0.023 Clinically significant DME AND/OR Center involved DME 42 0.051 Supplemental Table 1b Supplemental Table 1. Prevalence of Diabetic Retinopathy in the study by 1a) ETDRS severity level of the worst eye; 1b) DME level of the worst eye. Frequencies are calculated based on the subset of 819 analyzable participants. Worst ETDRS Level Description Fundus-based Clinically Significant Macular Edema Fundus based classification 10 No or Mild NPDR absent mtmDR- 12, 14A, 14B, 14C,14Z, 15, 20 Mild NPDR 10 No or Mild NPDR a) zone of retinal thickening > 1 disc area, part < 1 disc diameter from foveal center b) retinal thickening or adjacent hard exudates < 600µm from foveal center mtmDR+ 12, 14A, 14B, 14C, 14Z, 15, 20 Mild NPDR 35A, 35B, 35C, 35D, 35E, 35F, 43A, 43B, 47A, 47B, 47C, 47D Moderate NPDR absent or present mtmDR+ 53A, 53B, 53C, 53D, 53E Severe NPDR absent or present mtmDR+ vtDR+ 60, 61A, 61B, 65A, 65B, 65C, 71A, 71B, 71C, 71D, 75, 81, 85A, 85B PDR Supplemental Table 2. Mapping of Early Treatment of Diabetic Retinopathy Study (ETDRS) severity levels (worst eye) and combination with fundus based Diabetic Macular Edema (DME) to the dichotomous categories fundus mtmDR – (no or mild NPDR and no DME), fundus mtmDR + (more than moderate DR: more than mild DR or DME), as well as vtDR+ (vision threatening DR: severe NPDR, or PDR, or DME). NPDR = Non Proliferative DR.