NAAT EIA Interpretation Interpretation Recommendations Result Result Guidelines C.diff organism not Repeat testing will not be performed detected within 7 days Not Negative Negative Isolation may be discontinued unless Done CDI unlikely, consider other stool studies are pending such as causes of diarrhea. Norovirus/Rotovirus Repeat testing should not be performed Patients to remain in Special/Contact Toxigenic C.diff detected Isolation Positive Positive Positive Pharmacist to follow and assist with CDI C.diff infection treatment and antibiotic & PPI Consider an ID consult C. diff organism detected Toxin not detected Repeat testing will not be performed Clinical evaluation within 7 days, unless there is a significant necessary change in clinical symptoms (increased May represent frequency of diarrhea, fever, abdominal colonization. pain etc.) Positive Negative Indeterminate May indicate Patients to remain in Special/Contact C.difficile infection Isolation with a lower burden Pharmacist to follow and assist with of disease. antibiotic & PPI de-escalation May indicate false Consider an ID consult negative toxin test.
NAAT Result EIA Result Interpretation Interpretation Guidelines Recommendations Negative Not Done Negative C.diff organism not detected CDI unlikely, consider causes of diarrhea. Repeat testing will not be performed within 7 days Isolation may be discontinued unless other stool studies are pending such as Norovirus/Rotovirus Positive Positive Positive Toxigenic C.diff detected C.diff infection Repeat testing should not be performed Patients to remain in Special/Contact Isolation Pharmacist to follow and assist with CDI treatment and antibiotic & PPI Consider an ID consult Positive Negative Indeterminate C. diff organism detected Toxin not detected Clinical evaluation necessary May represent colonization. May indicate C.difficile infection with a lower burden of disease. May indicate false negative toxin test. Repeat testing will not be performed within 7 days, unless there is a significant change in clinical symptoms (increased frequency of diarrhea, fever, abdominal pain etc.) Patients to remain in Special/Contact Isolation Pharmacist to follow and assist with antibiotic & PPI de-escalation Consider an ID consult