Reproductive toxicity Rat, Crl:CD(SD)IGS Maternal toxicity: Maternal toxicity: Reduced body weight gain Luebker et al. UK COT, US EPA study) VAF/Plus NOAEL: 0.4 2005a Reproductive toxicity: LOAEL: 0.8 Reduced gestation length Reproductive toxicity: NOAEL: 0.4 Offspring toxicity: LOAEL: 0.8 Reduced body weight and body weight gain Offspring toxicity: NOAEL: < 0.4 LOAEL: 0.4 Other studies 28 day (Immunotoxicity study) Mouse, B6C3F1 NOAEL: 0.000166 Reduced SRBC plaque forming cell response Peden-Adams et al. US EPA, Swedish LOAEL: 0.00166 2008 EPA 60 day (Immunotoxicity Study) Mouse, C57BL6 NOAEL: 0.008 Reduced SRBC plaque forming cell response Dong et al. 2009 US EPA LOAEL: 0.083 90 day Mouse, C57BL6 NOAEL: 0.43 Impaired learning and memory; increased apoptosis in Long et al. 2013 US EPA (Neurotoxicity study) LOAEL: 2.15 hippocampal cells Developmental neurotoxicity Rat, Sprague Dawley NOAEL: 1.0 maternal and developmental None identified Butenhoff et al. US EPA neurotoxicity 2009/Chang et al. LOAEL: > 1.0 2009
Reproductive toxicity study) Rat, Crl:CD(SD)IGS VAF/Plus Maternal toxicity: NOAEL: 0.4 LOAEL: 0.8 Reproductive toxicity: NOAEL: 0.4 LOAEL: 0.8 Offspring toxicity: NOAEL: < 0.4 LOAEL: 0.4 Maternal toxicity: Reduced body weight gain Reproductive toxicity: Reduced gestation length Offspring toxicity: Reduced body weight and body weight gain Luebker et al. 2005a UK COT, US EPA Other studies 28 day (Immunotoxicity study) Mouse, B6C3F1 NOAEL: 0.000166 LOAEL: 0.00166 Reduced SRBC plaque forming cell response Peden-Adams et al. 2008 US EPA, Swedish EPA 60 day (Immunotoxicity Study) Mouse, C57BL6 NOAEL: 0.008 LOAEL: 0.083 Reduced SRBC plaque forming cell response Dong et al. 2009 US EPA 90 day (Neurotoxicity study) Mouse, C57BL6 NOAEL: 0.43 LOAEL: 2.15 Impaired learning and memory; increased apoptosis in hippocampal cells Long et al. 2013 US EPA Developmental neurotoxicity Rat, Sprague Dawley NOAEL: 1.0 maternal and developmental neurotoxicity LOAEL: > 1.0 None identified Butenhoff et al. 2009/Chang et al. 2009 US EPA