High grade evidence (I or II-1) linked to intermediate outcome; Fair or Moderate grade evidence (II-2 or II-3) directly linked to health outcome Poor III evidence or no linkage of evidence to health outcome Table 3: Net Effect of the Intervention [NE] More than a small relative impact on a frequent condition with a substantial burden of suffering; Substantial Or A large impact on an infrequent condition with a significant impact on the individual patient level. A small relative impact on a frequent condition with a substantial burden of suffering; Moderate or A moderate impact on an infrequent condition with a significant impact on the individual patient A negligible relative impact on a frequent condition with a substantial burden of suffering; Small Or A small impact on an infrequent condition with a significant impact on the individual patient level. Negative impact on patients; or Zero or No relative impact on either a frequent condition with a substantial burden Negative of suffering, or an infrequent condition with a significant impact on the individual patient level. 4: Final Grade of Strength of Recommendation [SR] The net benefit of the intervention Quality of Substantial Moderate Small Zero or Negative Evidence A B C D Good B B C D Fair I I I I Poor Strength of Recommendation [SR] SR
Fair High grade evidence (I or II-1) linked to intermediate outcome; or Moderate grade evidence (II-2 or II-3) directly linked to health outcome Poor III evidence or no linkage of evidence to health outcome Table 3: Net Effect of the Intervention [NE] Substantial More than a small relative impact on a frequent condition with a substantial burden of suffering; Or A large impact on an infrequent condition with a significant impact on the individual patient level. Moderate A small relative impact on a frequent condition with a substantial burden of suffering; or A moderate impact on an infrequent condition with a significant impact on the individual patient Small A negligible relative impact on a frequent condition with a substantial burden of suffering; Or A small impact on an infrequent condition with a significant impact on the individual patient level. Zero or Negative Negative impact on patients; or No relative impact on either a frequent condition with a substantial burden of suffering, or an infrequent condition with a significant impact on the individual patient level. 4: Final Grade of Strength of Recommendation [SR] The net benefit of the intervention Quality of Evidence Substantial Moderate Small Zero or Negative Good A B C D Fair B B C D Poor I I I I Strength of Recommendation [SR] SR