Table 2 Mediterranean diet and colorectal cancer risk. Main characteristics of studies identified in the CUP SLR Cases/ Author, Year, Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors Country (years) Agnoli, 2013 EPIC-Italy, 435/ Cancer registry Incidence, 0.49 (0.35-0.70) COL40938 Prospective 45 275 and hospital quantitative FFQ colorectal cancer Ptrend:0.030 Italy Cohort, 11.28 years records M/W 181/ Incidence, 0.54 (0.30-0.96) colorectal Ptrend:0.085 cancer, men Age, BMI, educational 254/ Incidence, 0.46 (0.30-0.72) trial, gender, colorectal cancer Ptrend:0.238 non-alcoholic Women 6-11 vs 0-1 beverage score 326/ Incidence, colon 0.54 (0.36-0.81) Intake, physical cancer Ptrend:0.110 activity, smoking, study 159/ Incidence, distal 0.44 (0.26-0.75) centre colon cancer Ptrend:0.093 82/ Incidence, 0.73 (0.33-1.61) proximal colon Ptrend:0.585 cancer 109/ Incidence, rectal 0.41 (0.20-0.81) cancer Ptrend:0.200 Bamia, 2013 3 EPIC, 724/ Incidence, Cancer registry, FFQ in most per 2 units 0.96 (0.92-1.00) COL40964 Prospective 480 308 colorectal cancer record linkage, centres. Denmark, 11.6 Cohort, trial health Insurance Modified France, Age: 25-70 rec, mortality Mediterranean 0.89 (0.80-0.99) 6-9 vs 0-3 score Germany, years, registry, trial Ptrend:0.02
Table 2 Mediterranean diet and colorectal cancer risk. Main characteristics of studies identified in the CUP SLR Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Agnoli, 2013 COL40938 Italy EPIC-Italy, Prospective Cohort, M/W 435/ 45 275 11.28 years Cancer registry and hospital records FFQ Incidence, colorectal cancer 6-11 vs 0-1 score 0.49 (0.35-0.70) Ptrend:0.030 Age, BMI, educational gender, non-alcoholic beverage Intake, physical activity, smoking, study centre 181/ Incidence, colorectal cancer, men 0.54 (0.30-0.96) Ptrend:0.085 254/ Incidence, colorectal cancer Women 0.46 (0.30-0.72) Ptrend:0.238 326/ Incidence, colon cancer 0.54 (0.36-0.81) Ptrend:0.110 159/ Incidence, distal colon cancer 0.44 (0.26-0.75) Ptrend:0.093 82/ Incidence, proximal colon cancer 0.73 (0.33-1.61) Ptrend:0.585 109/ Incidence, rectal cancer 0.41 (0.20-0.81) Ptrend:0.200 Bamia, 2013 COL40964 Denmark, France, Germany, EPIC, Prospective Cohort, Age: 25-70 years, 3 724/ 480 308 11.6 Cancer registry, record linkage, health Insurance rec, mortality registry, FFQ in most centres. Modified Mediterranean Incidence, colorectal cancer per 2 units 0.96 (0.92-1.00) 6-9 vs 0-3 score 0.89 (0.80-0.99) Ptrend:0.02 trial trial quantitative trial,