PFS, median (95% CI), 4.2 (2.9–7.0) 3.3 (2.7–4.2) 4.2 (2.8–6.9) 3.4 (2.8–4.5) months 30.6 31.5 ORR (95% CI), % 10.8 (4.4–20.9) 9.4 (4.2–17.7) TC2/3 or IC2/3 excluding 59 70 81 96 TC3 or IC3, n PFS HR (95% CI)b 0.96 (0.66–1.40) 0.85 (0.62–1.17) PFS, median (95% CI), 2.8 (1.5–4.7) 4.1 (2.8–5.6) 3.1 (2.0–5.3) 3.8 (2.8–4.8) months 16.9 18.5 12.5 ORR (95% CI), % 14.3 (7.1–24.7) TC1/2/3 or IC1/2/3 excluding 111 87 178 156 TC2/3 or IC2/3, n PFS HR (95% CI)b 1.08 (0.79–1.46) 1.01 (0.80–1.27) PFS, median (95% CI), 2.6 (1.5–3.0) 4.2 (2.8–5.7) 2.5 (1.6–2.8) 3.9 (2.8–4.3) months 13.5 11.2 16.0 ORR (95% CI), % 21.8 (13.7–32.0) TC0 and IC0, n 180 199 260 271
PFS, median (95% CI), months 4.2 (2.9–7.0) 3.3 (2.7–4.2) 4.2 (2.8–6.9) 3.4 (2.8–4.5) ORR (95% CI), % 30.6 10.8 (4.4–20.9) 31.5 9.4 (4.2–17.7) TC2/3 or IC2/3 excluding TC3 or IC3, n 59 70 81 96 PFS HR (95% CI)b 0.96 (0.66–1.40) 0.85 (0.62–1.17) PFS, median (95% CI), months 2.8 (1.5–4.7) 4.1 (2.8–5.6) 3.1 (2.0–5.3) 3.8 (2.8–4.8) ORR (95% CI), % 16.9 14.3 (7.1–24.7) 18.5 12.5 TC1/2/3 or IC1/2/3 excluding TC2/3 or IC2/3, n 111 87 178 156 PFS HR (95% CI)b 1.08 (0.79–1.46) 1.01 (0.80–1.27) PFS, median (95% CI), months 2.6 (1.5–3.0) 4.2 (2.8–5.7) 2.5 (1.6–2.8) 3.9 (2.8–4.3) ORR (95% CI), % 13.5 21.8 (13.7–32.0) 11.2 16.0 TC0 and IC0, n 180 199 260 271