Measure of ** = % direct dermal absorption, plus total % in skin methiocarb, both in compartment (at dose-site plus not-at dose- site) and on skin at: 8, 24, 72, 168 h; Conclusion: [Swab-washes of skin The total amount of [14C]-methiocarb absorbed at 8, 24, 72 & 168 h, systemically in an 8 h working day for humans was <1% before animal sacrifice] of the dose applied. Rat & See relevant See Dermal 2001: Dose 5–5000 µg Corn dust Conclusions: Fisher, P. human studies relevant absorption per cm2. contaminated with in vivo potential absorption, rat skin: <1% 14-March-2006 above studies (evaluation of [~0.0056 mg/mg-dust] [14C]-methiocarb above potential in vitro absorption: rat skin: (Document ID: the 4 studies above) 0.8% & human skin: 0.2% M-267700-01-1) 2005: Dose: 420 µg See relevant purity [Weber 2001, potential human absorption rate, (using in vivo per cm2. information above. above results) is <1%, from methiocarb Maas 2001, [0.084 mg/mg-dust] contaminated corn dust. The following equation Odon-Fuertet was used to calculate the potential in vivo human absorption rate: 2005, Rascle 2005) in vivo rat x [(in vitro human) ÷ (in vitro rat)]
Measure of methiocarb, both in and on skin at: 8, 24, 72, 168 h; [Swab-washes of skin at 8, 24, 72 & 168 h, before animal sacrifice] ** = % direct dermal absorption, plus total % in skin compartment (at dose-site plus not-at dose- site) Conclusion: The total amount of [14C]-methiocarb absorbed systemically in an 8 h working day for humans was <1% of the dose applied. Rat & human See relevant studies above See relevant studies above Dermal absorption (evaluation of the 4 studies above) [Weber 2001, Maas 2001, Odon-Fuertet 2005, Rascle 2005) 2001: Dose 5–5000 µg per cm2. [~0.0056 mg/mg-dust] 2005: Dose: 420 µg per cm2. [0.084 mg/mg-dust] Corn dust contaminated with [14C]-methiocarb See relevant purity information above. Conclusions: in vivo potential absorption, rat skin: <1% potential in vitro absorption: rat skin: 0.8% & human skin: 0.2% potential in vivo human absorption rate, (using above results) is <1%, from methiocarb contaminated corn dust. The following equation was used to calculate the potential in vivo human absorption rate: in vivo rat x [(in vitro human) ÷ (in vitro rat)] Fisher, P. 14-March-2006 (Document ID: M-267700-01-1)