hormone use, red meat death cert, state intake, smoking status, cancer registries family history of colorectal cancer 365/ Incidence, vs ≥44.9 ≤37.8 Age, aspirin use, BMI, 45 906 0.82 (0.60-1.10) COSM, colorectal cancer educational level, 7.1 years Larsson, 2006 Prospective Postal history of diabetes, COL40625 Cohort, Cancer registry Incidence, colon vs ≥44.9 ≤37.8 questionnaire smoking status, family 227/ 0.79 (0.53-1.17) Sweden Age: 45-79 cancer met-hours/day history of colorectal M cancer Incidence, rectal vs ≥44.9 ≤37.8 140/ 0.86 (0.53-1.37) cancer met-hours/day 368/ Incidence, Norwegian 75 219 colorectal high vs low 0.81 (0.54-1.23) Nord-Trondelag Nilsen, 2002 Health Study, 12 years cancer, women COL00306 Prospective Cancer registry Age Men high vs low 0.54 (0.37-0.79) Norway Cohort, 362/ Age: 20- Incidence, rectal high vs low 0.63 (0.36-1.12) M/W cancer BRHS, Wannamethee, Age, alcohol Prospective 135/ Incidence, vigorous vs 2001 General consumption, BMI, Cohort, 7 588 Questionnaire colorectal none to 0.95 (0.48-1.88) COL01187 practioners social class, cigarette Age: 40-59 18.8 years cancer, moderate UK smoking M Thune, 1996 Norwegian 228/ Incidence, Cancer registry Questionnaire 0.97 (0.63-1.50) COL00269 national health 81 516 cancer, men,
death cert, state cancer registries hormone use, red meat intake, smoking status, family history of colorectal cancer Larsson, 2006 COL40625 Sweden COSM, Prospective Cohort, Age: 45-79 M 365/ 45 906 7.1 years Cancer registry Postal questionnaire Incidence, colorectal cancer ≥44.9 vs ≤37.8 0.82 (0.60-1.10) Age, aspirin use, BMI, educational level, history of diabetes, smoking status, family history of colorectal cancer 227/ Incidence, colon cancer ≥44.9 vs ≤37.8 met-hours/day 0.79 (0.53-1.17) 140/ Incidence, rectal cancer ≥44.9 vs ≤37.8 met-hours/day 0.86 (0.53-1.37) Nilsen, 2002 COL00306 Norway Norwegian Nord-Trondelag Health Study, Prospective Cohort, Age: 20- M/W 368/ 75 219 12 years Cancer registry Incidence, colorectal cancer, women high vs low 0.81 (0.54-1.23) Age 362/ Men high vs low 0.54 (0.37-0.79) Incidence, rectal cancer high vs low 0.63 (0.36-1.12) Wannamethee, 2001 COL01187 UK BRHS, Prospective Cohort, Age: 40-59 M 135/ 7 588 18.8 years General practioners Questionnaire Incidence, colorectal cancer, vigorous vs none to moderate 0.95 (0.48-1.88) Age, alcohol consumption, BMI, social class, cigarette smoking Thune, 1996 COL00269 Norwegian national health 228/ 81 516 Cancer registry Questionnaire Incidence, cancer, men, 0.97 (0.63-1.50)