Substance 4Na HEDP avlogEC50 2.014 Number of species 2 1 Trophic levels covered Trophic EC50 Reliability Species Duration Type Source level (mg/L) 2 Invertebrate 48 h 527 Acute ECHA (1981) Daphnia magna 2 Invertebrate 96h 81 Acute ECHA (1977) Crassostrea virginica Annex 2: Human toxicity data A2: Toxicity data for the effect assessment of the studied substances NOAEL Calculated ED50 Exposure Tested Substance ingestion inhalation Source (kg/person/ time animal (mg/kg bw/day) (mg/m3) lifetime) AE C8-10 50 Chronic Rat HERA (2009b) 196.3 TAED 90 Subchronic Rat ECHA (1987) 176.7 ECHA/OECD SIDS Na-silicate 260 Subchronic Mouse 286.7 (Sawai et al. 1980) 4Na ECHA/OECD SIDS 24 Chronic Rat 94.22 HEDP (1979) Maleic 10 Chronic Rat ECHA (1983) 39.26 acid ECHA/OECD SIDS Glycerol Subchronic Rat 19630 (Hine, 1953) ECHA/OECD SIDS Glycerol 167 Subchronic Rat 60.88 1992) OECD SIDS (Horn Citric acid 1200 Chronic Rat 4711 et al, 1957) For the NOAEL measured for the inhalation route expressed in mg/m3, the body weight factor BW in the formula of paragraph 2.5 of the manuscript is replaced by the average human inhalation rate defined by USEtox (16 m3/day).
Substance 4Na HEDP avlogEC50 2.014 Number of species 2 Trophic levels covered 1 Reliability Species Trophic level Duration EC50 (mg/L) Type Source 2 Daphnia magna Invertebrate 48 h 527 Acute ECHA (1981) 2 Crassostrea virginica Invertebrate 96h 81 Acute ECHA (1977) Annex 2: Human toxicity data A2: Toxicity data for the effect assessment of the studied substances Substance NOAEL ingestion (mg/kg bw/day) inhalation (mg/m3) Exposure time Tested animal Source Calculated ED50 (kg/person/ lifetime) AE C8-10 50 Chronic Rat HERA (2009b) 196.3 TAED 90 Subchronic Rat ECHA (1987) 176.7 Na-silicate 260 Subchronic Mouse ECHA/OECD SIDS (Sawai et al. 1980) 286.7 4Na HEDP 24 Chronic Rat ECHA/OECD SIDS (1979) 94.22 Maleic acid 10 Chronic Rat ECHA (1983) 39.26 Glycerol Subchronic Rat ECHA/OECD SIDS (Hine, 1953) 19630 Glycerol 167 Subchronic Rat ECHA/OECD SIDS 1992) 60.88 Citric acid 1200 Chronic Rat OECD SIDS (Horn et al, 1957) 4711 For the NOAEL measured for the inhalation route expressed in mg/m3, the body weight factor BW in the formula of paragraph 2.5 of the manuscript is replaced by the average human inhalation rate defined by USEtox (16 m3/day).