() II 5,109 Study was conducted on the After adjustment for risk factors, women with The median (IQR) basis of a study population of 25(OH)D concentrations <25 nmol/L had 25(OH)D Australian 11,358 women who were increased risk of having an SGA,10th-percentile concentration for study attending first-trimester Down infant (aOR: 1.58; 95% CI: 1.06, 2.35). the total syndrome screening between population was October 2006 and September 56.4 nmol/L 2007 in NSW. nmol/L). Cases of each study outcome of interest were randomly selected from the maternal screening population using a computerised function. Mode of birth Study ref Evidence Sample Setting/population Findings Comments Level size () IV 1,550 Among pregnant women in a There was no association between early vitamin D Deficient:<50 maternity service that deficiency and Caesarean section (p=0.71). nmol/L (n=849 Australian recommends routine [55%]) study antenatal screening and Insufficient: 50-74 advises supplementation nmol/L (n=571 where necessary, Vitamin D [37%]) serum concentrations were Replete: >75nmol/L measured in early and late (n=130 [8%]) pregnancy. The relationship between initial vitamin D status, maternal factors and pregnancy outcomes were estimated.
() II Australian study 5,109 Study was conducted on the basis of a study population of 11,358 women who were attending first-trimester Down syndrome screening between October 2006 and September 2007 in NSW. Cases of each study outcome of interest were randomly selected from the maternal screening population using a computerised function. After adjustment for risk factors, women with 25(OH)D concentrations <25 nmol/L had increased risk of having an SGA,10th-percentile infant (aOR: 1.58; 95% CI: 1.06, 2.35). The median (IQR) 25(OH)D concentration for the total population was 56.4 nmol/L nmol/L). Mode of birth Study ref Evidence Level Sample size Setting/population Findings Comments () IV Australian study 1,550 Among pregnant women in a maternity service that recommends routine antenatal screening and advises supplementation where necessary, Vitamin D serum concentrations were measured in early and late pregnancy. The relationship between initial vitamin D status, maternal factors and pregnancy outcomes were estimated. There was no association between early vitamin D deficiency and Caesarean section (p=0.71). Deficient:<50 nmol/L (n=849 [55%]) Insufficient: 50-74 nmol/L (n=571 [37%]) Replete: >75nmol/L (n=130 [8%])