Skin and subcutaneous tissue disorders Rash 69 5 0 30 1 0 Alopecia 14 0 0 11 0 0 Gastrointestinal disorders Diarrhoea 48 5 <1 36 2 0 Stomatitis 22 <1 0 12 0 0 Dyspepsia 17 <1 0 13 <1 0 Flatulence 13 0 0 9 <1 0 Metabolism and nutrition disorders Weight decreased 39 2 0 29 <1 0 General disorders and administration site conditions Pyrexia 36 3 0 30 4 0 Fatigue 73 14 2 70 13 2 Rigors 12 0 0 9 0 0 Infections and infestations Infection* 31 3 <1 24 6 <1 Psychiatric disorders Depression 19 2 0 14 <1 0 Respiratory, thoracic and mediastinal disorders Cough 16 0 0 11 0 0 Nervous system disorders Headache 15 <1 0 10 0 0 Neuropathy 13 1 <1 10 <1 0 infections, with or without neutropenia, have included pneumonia, sepsis and cellulitis. *severe Further Information on Adverse Reactions of Special Interest:
Skin and subcutaneous tissue disorders Rash Alopecia 69 14 5 0 0 0 30 11 1 0 0 0 Gastrointestinal disorders Diarrhoea Stomatitis Dyspepsia Flatulence 48 22 17 13 5 <1 <1 0 <1 0 0 0 36 12 13 9 2 0 <1 <1 0 0 0 0 Metabolism and nutrition disorders Weight decreased 39 2 0 29 <1 0 General disorders and administration site conditions Pyrexia Fatigue Rigors 36 73 12 3 14 0 0 2 0 30 70 9 4 13 0 0 2 0 Infections and infestations Infection* 31 3 <1 24 6 <1 Psychiatric disorders Depression 19 2 0 14 <1 0 Respiratory, thoracic and mediastinal disorders Cough 16 0 0 11 0 0 Nervous system disorders Headache Neuropathy 15 13 <1 1 0 <1 10 10 0 <1 0 0 *severe infections, with or without neutropenia, have included pneumonia, sepsis and cellulitis. Further Information on Adverse Reactions of Special Interest: