cisplatin. Evaluate the benefits and adverse effects of using drugs such as cisplatin. 3.3.14 0.4 Devise synthetic routes, Students produce flow-charts for June 2006 RSC synthesis resource: Organic synthesis. weeks with up to four steps, to synthetic pathways involving the Unit 4 Q6 make specific organic reactions in the specification. Devise synthetic routes compounds using the January 2003 Synthesis of ibuprofen: to make specified reactions in the Students use them to devise Unit 4 Q7 compounds. specification. synthetic routes to make a range of different compounds. June 2002 Explain why processes are Unit 4 Q7 designed to avoid solvents, non-hazardous starting Specimen Paper materials and have steps Unit 4 Q8 with high atom economy. 3.3.15 1.8 Understand the use of TMS Students predict the number, June 2013 NMR technique: NMR weeks and the scale for position, relative intensity and Unit 4 Q7 δ chemical shift. splitting of signals in the 1H NMR Use 1H and 13C NMR spectrum of compounds. January 2013 Database of spectra for organic to deduce information Understand the use of Unit 4 Q5 compounds: about the structure of deuterated solvents or Students predict the number and organic molecules. CCl4 position of signals in the 13C NMR June 2012 spectrum of compounds. Unit 4 Q8 Spectra school: Understand similarities Deduce the structure of and differences compounds using 1H NMR Students use data from NMR, and January 2011 between 1H and 13C including the number, analytical methods on the Unit 4 Q5 NMR position, relative intensity specification, to deduce the January 2003
cisplatin. Evaluate the benefits and adverse effects of using drugs such as cisplatin. 3.3.14 Organic synthesis. Devise synthetic routes to make specified compounds. 0.4 weeks Devise synthetic routes, with up to four steps, to make specific organic compounds using the reactions in the specification. Explain why processes are designed to avoid solvents, non-hazardous starting materials and have steps with high atom economy. Students produce flow-charts for synthetic pathways involving the reactions in the specification. Students use them to devise synthetic routes to make a range of different compounds. June 2006 Unit 4 Q6 January 2003 Unit 4 Q7 June 2002 Unit 4 Q7 Specimen Paper Unit 4 Q8 RSC synthesis resource: Synthesis of ibuprofen: 3.3.15 NMR Use 1H and 13C NMR to deduce information about the structure of organic molecules. Understand similarities and differences between 1H and 13C NMR 1.8 weeks Understand the use of TMS and the δ scale for chemical shift. Understand the use of deuterated solvents or CCl4 Deduce the structure of compounds using 1H NMR including the number, position, relative intensity Students predict the number, position, relative intensity and splitting of signals in the 1H NMR spectrum of compounds. Students predict the number and position of signals in the 13C NMR spectrum of compounds. Students use data from NMR, and analytical methods on the specification, to deduce the June 2013 Unit 4 Q7 January 2013 Unit 4 Q5 June 2012 Unit 4 Q8 January 2011 Unit 4 Q5 January 2003 NMR technique: Database of spectra for organic compounds: Spectra school: