TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity oral 17 – B.2. Acute toxicity dermal 17 – B.3. Acute toxicity inhalation 18 – B.4. Irritation skin (in vitro) 18 – B.5. Irritation skin (in vitro) 19 – B.6. Irritation eye (in vitro) 20 – B.7. Irritation eye 20 – B.8. Skin sensitisation mouse local lymph node assay (LLNA) 21 – B.9. Skin sensitisation human volunteers 21 – B.10. Repeat dose toxicity 22 B.11. Genotoxicity bacteria 24 – B.12. Genotoxicity in vitro 25 – B.13. Toxicity to reproduction/development 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 29 C.1. Environmental Fate 29 C.1.1. Ready biodegradability 29 C.2. Ecotoxicological Investigations 29 C.2.1. Acute toxicity to fish 29 C.2.2. Acute toxicity to aquatic invertebrates 30 C.2.3. Algal growth inhibition test 31 BIBLIOGRAPHY 33 SUMMARY The following details will be published in the NICNAS Chemical Gazette:
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 12 7.1. Environmental Exposure & Fate Assessment 12 7.1.1. Environmental Exposure 12 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 13 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 14 7.3. Environmental Risk Assessment 14 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity – oral 17 B.2. Acute toxicity – dermal 17 B.3. Acute toxicity – inhalation 18 B.4. Irritation – skin (in vitro) 18 B.5. Irritation – skin (in vitro) 19 B.6. Irritation – eye (in vitro) 20 B.7. Irritation – eye 20 B.8. Skin sensitisation – mouse local lymph node assay (LLNA) 21 B.9. Skin sensitisation – human volunteers 21 B.10. Repeat dose toxicity 22 B.11. Genotoxicity – bacteria 24 B.12. Genotoxicity – in vitro 25 B.13. Toxicity to reproduction/development 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 29 C.1. Environmental Fate 29 C.1.1. Ready biodegradability 29 C.2. Ecotoxicological Investigations 29 C.2.1. Acute toxicity to fish 29 C.2.2. Acute toxicity to aquatic invertebrates 30 C.2.3. Algal growth inhibition test 31 BIBLIOGRAPHY 33 SUMMARY The following details will be published in the NICNAS Chemical Gazette: