Systems Biotechnology Group Model-based metabolic engineering for bacterial systems Systems Biotechnology combines methods from engineering sciences, n microbiology and computational sciences to improve biotechnological processes. The available wet and dry laboratory space is extensively used for applications in model-based metabolic engineering. criteria as regulation dependent, resource fg-systembiotechnologie Phone +49.89.289.15761 dependent, dynamic, or static. One of this year’s highlights was the Two members of our group successfully publication of a review in Trends in Micro- applied for an add-on fellowship of 12k biology, which describes mathematical Euros from the Joachim Herz Stiftung, models that are able to reproduce diauxic Prof. Dr.-Ing. Hamburg, for interdisciplinary qualifica- growth behavior in bacterial systems. Andreas Kremling tion. Furthermore, we launched the SBT This behavior is a hallmark of bacterial site on Facebook and have now reached regulation and was first discovered by the Contact over 70 followers. Nobel laureate J. Monod. These models can be classified according to a number of Fundamentals for Experimental Analysis and Mathematical Modeling of Cellular Networks photosynthetically active organism extruding sugar molecules together with Regulation of transcriptional and bio- heterotrophic organisms capable of pro- chemical processes in a bacterial cell ducing industrially interesting compounds. is essential for surviving in changing To this end a photobioreactor is employed environmental conditions and understand- which allows cultivation and collection of a ing of the events taking place is pivotal vast amount of data used to describe the for using bacteria in industrially interesting population-based variations in the overall applications. Research of the systems process. biotechnology group targets different key regulatory devices, like the phosphotrans- Projects e:biofilm, BMBF e:Bio initiative; regula- n ferase system in Pseudomonas putida tory influence of the PTS on physiology or the ComRS two component system in Streptococcus mutans. The and biotechnological production with experimental information derived either in the laboratory or by group’s own P. putida, DFG collaboration partners gives rise to mathematic models that contribute to a better understanding of cellular processes. Another research focus lies on the establishment of a co-culture between a 150 Systems Biotechnology Group
Systems Biotechnology Group Model-based metabolic engineering for bacterial systems n Systems Biotechnology combines methods from engineering sciences, microbiology and computational sciences to improve biotechnological processes. The available wet and dry laboratory space is extensively used for applications in model-based metabolic engineering. Prof. Dr.-Ing. Andreas Kremling Contact fg-systembiotechnologie Phone +49.89.289.15761 One of this year’s highlights was the publication of a review in Trends in Micro- biology, which describes mathematical models that are able to reproduce diauxic growth behavior in bacterial systems. This behavior is a hallmark of bacterial regulation and was first discovered by the Nobel laureate J. Monod. These models can be classified according to a number of criteria as regulation dependent, resource dependent, dynamic, or static. Two members of our group successfully applied for an add-on fellowship of 12k Euros from the Joachim Herz Stiftung, Hamburg, for interdisciplinary qualifica- tion. Furthermore, we launched the SBT site on Facebook and have now reached over 70 followers. Fundamentals for Experimental Analysis and Mathematical Modeling of Cellular Networks Regulation of transcriptional and bio- chemical processes in a bacterial cell is essential for surviving in changing environmental conditions and understand- ing of the events taking place is pivotal for using bacteria in industrially interesting applications. Research of the systems biotechnology group targets different key regulatory devices, like the phosphotrans- ferase system in Pseudomonas putida or the ComRS two component system in Streptococcus mutans. The experimental information derived either in the group’s own laboratory or by collaboration partners gives rise to mathematic models that contribute to a better understanding of cellular processes. Another research focus lies on the establishment of a co-culture between a photosynthetically active organism extruding sugar molecules together with heterotrophic organisms capable of pro- ducing industrially interesting compounds. To this end a photobioreactor is employed which allows cultivation and collection of a vast amount of data used to describe the population-based variations in the overall process. Projects n e:biofilm, BMBF e:Bio initiative; regula- tory influence of the PTS on physiology and biotechnological production with P. putida, DFG 150 Systems Biotechnology Group