Table 2: Growth Factors that are Involved in Wound Healing GROWTH FACTOR FUNCTION Mitogen for vascular endothelial cells in angiogenesis Vascular Endothelial Growth Factor (VEGF) (Petreaca 2008). et al., Transforming growth Mitogenic or antiproliferative depending on cell type; factor beta (TGF-b) regulates ECM formation. Anti-inflammatory effect in healing (Frangogiannis, 2008). Granulocyte-colony Proliferation/differentiation stimulator in neutrophils and granulocytes (Seshadri 2008). stimulating factor et al., Pleiotropic stimulator and activator of granulocyte colony and monocyte proliferation (Sugano 2005). et al., stimulating factor Nerve growth factor Differentiation of sensory, cholinergic and sympathetic neurons (Madduri 2009). (NGF) et al., Differentiation/survival of sensory neurons (Madduri Neurotrophins (NT-3, 4, 5 &6) 2009). et al., Platelet-derived growth Mitogenic and differentiating activity in endothelial cells and neurons (Lin 2009). factor (PDGF) et al., Stimulates proliferation of erythroid progenitors; Erythropoietin (EPO) induces haemoglobin production (Sorg 2009). et al.,
Table 2: Growth Factors that are Involved in Wound Healing GROWTH FACTOR FUNCTION Vascular Endothelial Growth Factor (VEGF) Mitogen for vascular endothelial cells in angiogenesis (Petreaca et al., 2008). Transforming growth factor beta (TGF-b) Mitogenic or antiproliferative depending on cell type; regulates ECM formation. Anti-inflammatory effect in healing (Frangogiannis, 2008). Granulocyte-colony stimulating factor Proliferation/differentiation stimulator in neutrophils and granulocytes (Seshadri et al., 2008). colony stimulating factor Pleiotropic stimulator and activator of granulocyte and monocyte proliferation (Sugano et al., 2005). Nerve growth factor (NGF) Differentiation of sensory, cholinergic and sympathetic neurons (Madduri et al., 2009). Neurotrophins (NT-3, 4, 5 &6) Differentiation/survival of sensory neurons (Madduri et al., 2009). Platelet-derived growth factor (PDGF) Mitogenic and differentiating activity in endothelial cells and neurons (Lin et al., 2009). Erythropoietin (EPO) Stimulates proliferation of erythroid progenitors; induces haemoglobin production (Sorg et al., 2009).