1 Table Studies reporting diagnostc accuracy data on the use of mpMRI in Population 1 Study ID Used in Study type Level of Location Study population characteristics: Description of Description of Description Relevant Measurement Intervention: Intervention: of outcomes of outcomes: Enrolmenta Setting n Reference assessed T mpMRI Reader PI-RADS Designb Age years standard: experience cutoffd Coil PSA ng/ml Biopsy type Contrast Prior biopsy Baldisserotto Yes Case series III-2 Brazil n: 54 3.0T 2 uroradiologists: TRUSGB + TP, TN, ≥4 et al. (2016) with 1 or 10 cog-MRI FP, FN Consecutive Tertiary Age: mean 65.9 (range 53-81) Coil: PPAC - key study years’ experience hospital Retrospective PSA: mean 8.4 (SD 6.5) Contrast: NR Prior biopsy: NR Baur et al. Yes Case series III-2 Germany n:45 3.0T 2 readers with 3 US/MRI TP, TN, ≥4 (2016) - key or 5 years’ FGB FP, FN Consecutive Tertiary Age: Mean 66 (range 46-81) Coil: PPAC study experience in hospital Prospective PSA: mean 12.3 (range 5.2-70) Contrast: prostate imaging gadobutrol Prior biopsy: 100% Dikaios et al. Yes Case series III-2 UK n: 85 1.5T 2 radiologists TRUSGB TP, TN, ≥ 4 (2015) - key with 5 or 7 years FP, FN NR Tertiary Age: 63 (range 45-77) Coil: PPAC study mpMRI hospital Retrospective PSA: mean 8.66 (range 0.2-39) Contrast: experience. Prior biopsy: NR Dedicated training of readers was undertaken
1 Table Studies reporting diagnostc accuracy data on the use of mpMRI in Population 1 Study ID Used in Study type Enrolmenta Designb Level of Location Setting Study population characteristics: n Age years PSA ng/ml Prior biopsy Description of Intervention: T Coil Contrast Description of Intervention: mpMRI Reader experience Description of Reference standard: Biopsy type Relevant outcomes assessed Measurement of outcomes: PI-RADS cutoffd Baldisserotto et al. (2016) - key study Yes Case series Consecutive Retrospective III-2 Brazil Tertiary hospital n: 54 Age: mean 65.9 (range 53-81) PSA: mean 8.4 (SD 6.5) Prior biopsy: NR 3.0T Coil: PPAC Contrast: NR 2 uroradiologists: with 1 or 10 years’ experience TRUSGB + cog-MRI TP, TN, FP, FN ≥4 Baur et al. (2016) - key study Yes Case series Consecutive Prospective III-2 Germany Tertiary hospital n:45 Age: Mean 66 (range 46-81) PSA: mean 12.3 (range 5.2-70) Prior biopsy: 100% 3.0T Coil: PPAC Contrast: gadobutrol 2 readers with 3 or 5 years’ experience in prostate imaging US/MRI FGB TP, TN, FP, FN ≥4 Dikaios et al. (2015) - key study Yes Case series NR Retrospective III-2 UK Tertiary hospital n: 85 Age: 63 (range 45-77) PSA: mean 8.66 (range 0.2-39) Prior biopsy: NR 1.5T Coil: PPAC Contrast: 2 radiologists with 5 or 7 years mpMRI experience. Dedicated training of readers was undertaken TRUSGB TP, TN, FP, FN ≥ 4