II Adults (aged 33 All participants were Blood pressure 15 4 Normal sodium Mean (supine and et al. - 71), with provided with diet: 183 (SEM: 11) difference standing), (1987), hypertension captopril 50mg twice mmHg between low mean arterial UK (DBP> 95 daily for one month. sodium diet to pressure Low sodium diet: study mmHg) (mean Following this period, normal sodium [] 83 (SEM: 10) BP: participants were diet: Insufficient mmHg 162/107mmHg) instructed to reduce data in paper Seated: to calculate dietary sodium to 70 – (p<0.001) MAP 80 mmol/day for two SBP: -13mmHg weeks. Participants (SEM: 3.29, CI: were then randomised -19.45, -6.55) to start one of two DBP: cross-over arms: (SEM: 3.05, CI: 1. Restricted sodium -14.98, -3.02) diet + captopril and 100mmol sodium (NaCl) tablets/day 2. Restricted sodium diet + captopril and placebo Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing study Reporting Funding source randomisation concealment follow-up early for benefit all where outcome required results
et al. (1987), UK [] study II Adults (aged 33 - 71), with hypertension (DBP> 95 mmHg) (mean BP: 162/107mmHg) All participants were provided with captopril 50mg twice daily for one month. Following this period, participants were instructed to reduce dietary sodium to 70 – 80 mmol/day for two weeks. Participants were then randomised to start one of two cross-over arms: 1. Restricted sodium diet + captopril and 100mmol sodium (NaCl) tablets/day 2. Restricted sodium diet + captopril and placebo Blood pressure (supine and standing), mean arterial pressure Insufficient data in paper to calculate MAP 15 4 Normal sodium diet: 183 (SEM: 11) mmHg Low sodium diet: 83 (SEM: 10) mmHg (p<0.001) Mean difference between low sodium diet to normal sodium diet: Seated: SBP: -13mmHg (SEM: 3.29, CI: -19.45, -6.55) DBP: (SEM: 3.05, CI: -14.98, -3.02) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to follow-up Use of where required Ceasing study early for benefit Reporting all outcome results Funding source