FDA Paroxetine 10 Yes 8 T8 102 - - No - 13 Yes Paroxetine Paroxetine 20 104 - - - 19 study II Paroxetine 30 101 - - - 21 Paroxetine 40 102 - - - 22 Placebo 51 - - - 4 FDA Paroxetine 25-62.5 Yes 8 T8 212 63.2 40.7 No 36 47 Yes Paroxetine Placebo 211 63.0 39.8 19 17 study III FDA Paroxetine 12.5-50 Yes 12 T12 104 48.1 70.4±5.9 No 10 22 Yes Paroxetine Placebo 109 63.3 69.4±5.4 9 13 study IV FDA Sertraline Sertraline 50-200 Yes 8 T8 861 - - No 138 112 Yes study (ID: Placebo 853 - - 77 51 3254400) FDA Venlafaxine 75-375 Yes 8 T8 1033 - - No 186 238 Yes Venlafaxine Placebo 609 - - 61 55 study I FDA Venlafaxine 75-375 Yes 8 T8 357 - - No 61 31 Yes Venlafaxine Placebo 285 - - 31 23 study II (Feiger et al. Sertraline 148 Yes 6 T6 82 48 43.0 ± 1.1 No 19 17 Yes 1996)() (Feighner et al. Bupropion 345± 60 No 6 T6 60 63.3 40.9 No 10 4 Yes 1991)() Fluoxetine 26± 6 60 63.3 42.9 7 5 (Feighner et al. Citalopram 10 No 6 T6 131 63 38 No 17 12 Yes 1999)() Citalopram 20 130 66 39 20 17
FDA Paroxetine study II Paroxetine Paroxetine Paroxetine Paroxetine Placebo 10 20 30 40 Yes 8 T8 102 104 101 102 51 - - - - - - - - - - No - - - - - 13 19 21 22 4 Yes FDA Paroxetine study III Paroxetine Placebo 25-62.5 Yes 8 T8 212 211 63.2 63.0 40.7 39.8 No 36 19 47 17 Yes FDA Paroxetine study IV Paroxetine Placebo 12.5-50 Yes 12 T12 104 109 48.1 63.3 70.4±5.9 69.4±5.4 No 10 9 22 13 Yes FDA Sertraline study (ID: 3254400) Sertraline Placebo 50-200 Yes 8 T8 861 853 - - - - No 138 77 112 51 Yes FDA Venlafaxine study I Venlafaxine Placebo 75-375 Yes 8 T8 1033 609 - - - - No 186 61 238 55 Yes FDA Venlafaxine study II Venlafaxine Placebo 75-375 Yes 8 T8 357 285 - - - - No 61 31 31 23 Yes (Feiger et al. 1996)() Sertraline 148 Yes 6 T6 82 48 43.0 ± 1.1 No 19 17 Yes (Feighner et al. 1991)() Bupropion Fluoxetine 345± 60 26± 6 No 6 T6 60 60 63.3 63.3 40.9 42.9 No 10 7 4 5 Yes (Feighner et al. 1999)() Citalopram Citalopram 10 20 No 6 T6 131 130 63 66 38 39 No 17 20 12 17 Yes