What are the size of plasma cells? 10-20um Does a plasma cell have abundant cytoplasmic Abundant cytoplasmic immunoglobulin immunoglobulin or abundant surface immunoglobulin Where are plasma cells located? In the germinal centers of peripheral lymphoid organs Do plasma cells divide? No Plasma can differentiate into what type of Memory B cells cells? Where are memory B cells located? Germinal centers How long due memory cells remain activated? Months or years What percentage of circulating lymphocytes are 60-80% T What are lymphocyte precursors called? Thymocytes Where do thymocytes enter and migrate? They enter the thymus and migrate to the cortex What is T cell differentiation driven by? Chemokines What are the early surface markers of T cells? CD44 and CD25 Are distinct surface markers created during Yes specific stages of development How long does T cell differentiation take? 3 weeks What are the thymic stromal cells? Epithelial macrophages, fibroblasts and dendritic cells What percentage of the cortical cells die 97% intrathymically before maturing completely? Early thymocytes lack which CD markers? CD4 and CD8 Double negative thymocytes proliferate under IL-7 the influence of which IL? How many chains does CD3 have? 8 The alpha and beta chains have variable regions. It means that those regions recognize specific What does that mean? antigens When a functional beta chain is seen on the cell A signal is sent to suppress further beta surface, what happens? gene rearrangements Signaling by the beta chain triggers what Allows thymocyte to become CD4 and CD8 response in the thymocyte? positive Do thymocytesexpress gamma and delta chains? Yes Thymocytes with gamma and delta chains are + Negative or for CD4 and CD8? – Where are negative CD4 and negative CD8 Intestinal epithelium and pulmonary epithelium cells located? Cells that are negative for CD4 and negative for Natural Killer cell CD8 may behave like what other type of cell? When cells express both CD4 and CD8 Double positive cells antigens, what are the cells called? Thymocytes that are unable to recognize self In the thymus antigens die where?
What are the size of plasma cells? 10-20um Does a plasma cell have abundant cytoplasmic immunoglobulin or abundant surface immunoglobulin Abundant cytoplasmic immunoglobulin Where are plasma cells located? In the germinal centers of peripheral lymphoid organs Do plasma cells divide? No Plasma can differentiate into what type of cells? Memory B cells Where are memory B cells located? Germinal centers How long due memory cells remain activated? Months or years What percentage of circulating lymphocytes are T 60-80% What are lymphocyte precursors called? Thymocytes Where do thymocytes enter and migrate? They enter the thymus and migrate to the cortex What is T cell differentiation driven by? Chemokines What are the early surface markers of T cells? CD44 and CD25 Are distinct surface markers created during specific stages of development Yes How long does T cell differentiation take? 3 weeks What are the thymic stromal cells? Epithelial macrophages, fibroblasts and dendritic cells What percentage of the cortical cells die intrathymically before maturing completely? 97% Early thymocytes lack which CD markers? CD4 and CD8 Double negative thymocytes proliferate under the influence of which IL? IL-7 How many chains does CD3 have? 8 The alpha and beta chains have variable regions. What does that mean? It means that those regions recognize specific antigens When a functional beta chain is seen on the cell surface, what happens? A signal is sent to suppress further beta gene rearrangements Signaling by the beta chain triggers what response in the thymocyte? Allows thymocyte to become CD4 and CD8 positive Do thymocytesexpress gamma and delta chains? Yes Thymocytes with gamma and delta chains are + or – for CD4 and CD8? Negative Where are negative CD4 and negative CD8 cells located? Intestinal epithelium and pulmonary epithelium Cells that are negative for CD4 and negative for CD8 may behave like what other type of cell? Natural Killer cell When cells express both CD4 and CD8 antigens, what are the cells called? Double positive cells Thymocytes that are unable to recognize self antigens die where? In the thymus