p<0.00001, 4 weeks - All-cause mortality: or more: p=0.10), In cohort studies, cholesterol (total: there was a p<0.001, 4 weeks or more: 0.27) and association between triglycerides (total: higher sodium intake p=0.0008, 4 weeks or and increased risk of more: p=0.09) all-cause mortality. - Changes in LDL Data from RCTs was (p=0.15), HDL insufficient to (p=0.91) were not suggest an effect or significant regardless lack of effect. of duration (GRADE quality of evidence: very low) The following The databases The databases In the first phase, In the trial phase, Date range: Jan 2003 Search strategy databases were searched included: searched included: relevant systematic relevant systematic Dec 2012. – searched: Cochrane Library, PubMed, Embase, reviews were located reviews were located Databases searched: - Cochrane Medline, Embase, and Cochrane Central and their references and their references Cochrane reviews, Hypertension Group CAB abstracts, (1950 July 2011) used. used. Embase, Medline, – Specialised Register registry and SIGLE - No language In the second phase, In the second phase, PubMed, Web of (1948 November (to May 1998). restrictions the search strategy the search strategy Science – 2012) - Updated search involved searching involved searching - Peer-reviewed - Cochrane Central included the the following the following original research Register of Cochrane library and databases (from the databases for studies, systematic Controlled Trials Medline (does not date of the search additional systematic reviews and (2012) give date) completed in the reviews (from the (for - Medline (1946 Reference lists of reviewed SLRs date of the search background and – – 2012) articles also reviewed August 2011): completed in the cross-check of - Embase (1974 for additional studies. Cochrane Central reviewed SLRs references) published – – 2012) - No language Register of August 2011): in English Reference lists of restrictions Controlled Trials, Cochrane Central articles also reviewed Medline, Embase, Register of for additional studies. WHO International Controlled Trials, - No language Clinical Trials PubMed database (to restrictions Registry Platform, be undertaken if the
p<0.00001, 4 weeks or more: p=0.10), cholesterol (total: p<0.001, 4 weeks or more: 0.27) and triglycerides (total: p=0.0008, 4 weeks or more: p=0.09) - Changes in LDL (p=0.15), HDL (p=0.91) were not significant regardless of duration - All-cause mortality: In cohort studies, there was a association between higher sodium intake and increased risk of all-cause mortality. Data from RCTs was insufficient to suggest an effect or lack of effect. (GRADE quality of evidence: very low) Search strategy The following databases were searched: - Cochrane Hypertension Group Specialised Register (1948 – November 2012) - Cochrane Central Register of Controlled Trials (2012) - Medline (1946 – 2012) - Embase (1974 – 2012) Reference lists of articles also reviewed for additional studies. - No language restrictions The databases searched included: Cochrane Library, Medline, Embase, CAB abstracts, registry and SIGLE (to May 1998). - Updated search included the Cochrane library and Medline (does not give date) Reference lists of articles also reviewed for additional studies. - No language restrictions The databases searched included: PubMed, Embase, and Cochrane Central (1950 – July 2011) - No language restrictions In the first phase, relevant systematic reviews were located and their references used. In the second phase, the search strategy involved searching the following databases (from the date of the search completed in the reviewed SLRs – August 2011): Cochrane Central Register of Controlled Trials, Medline, Embase, WHO International Clinical Trials Registry Platform, In the phase, relevant systematic reviews were located and their references used. In the second phase, the search strategy involved searching the following databases for additional systematic reviews (from the date of the search completed in the reviewed SLRs – August 2011): Cochrane Central Register of Controlled Trials, PubMed database (to be undertaken if the Date range: Jan 2003 – Dec 2012. Databases searched: Cochrane reviews, Embase, Medline, PubMed, Web of Science - Peer-reviewed original research studies, systematic reviews and (for background and cross-check of references) published in English trial