McQuay et al., Bilateral third Pain Intensity A combination of 20 The combination 1989. molar removal mg codeine base produced significantly and ibuprofen 400 greater pain relief and mg was compared doubled the hours of with ibuprofen 400 minimum pain intensity mg in a randomised and maximal relief on double-blind the day of surgery. study of multiple doses in 25 patients after bilateral third molar removal. McQuay et al., molar Pain Intensity on Study compared The ibuprofen 1992. surgery 4-point verbal ibuprofen + codeine combination produced rating scale and combination (400 significantly greater pain relief on mg ibuprofen/25.6 analgesia than the rating scale mg codeine paracetamol phosphate) with a combination, both on paracetamol + single-dose analysis of codeine + caffeine the and second combination ( I g days and on paracetamol + 16 measures for days mg codeine I , 2, 3 and 4 (P< 0.02 for phosphate + 60 mg all comparisons). caffeine) for pain relief over 6 days two-stage bilateral lower third molar removal. Randomised crossover study (n=30) Modaresi et al., Root canal Tooth sensitivity Acetaminophen 300 Significantly lower tooth 2006. therapy levels mg + 20 mg codeine sensitivity levels (TSLs) vs ibuprofen 200 mg were observed with the acetaminophen-codeine and ibuprofen groups, which was more significant in the ibuprofen group. Nautu et al., 2009. Systematic review VAS Codeine + None of the studies of nine trials paracetamol vs found the combination evaluating pain of codeine + relief in post paracetamol to be abdominal superior to NSAIDs in surgery pain controlling pain.
McQuay et al., 1989. Bilateral third molar removal Pain Intensity A combination of 20 mg codeine base and ibuprofen 400 mg was compared with ibuprofen 400 mg in a randomised double-blind study of multiple doses in 25 patients after bilateral third molar removal. The combination produced significantly greater pain relief and doubled the hours of minimum pain intensity and maximal relief on the day of surgery. McQuay et al., 1992. molar surgery Pain Intensity on 4-point verbal rating scale and pain relief on rating scale Study compared ibuprofen + codeine combination (400 mg ibuprofen/25.6 mg codeine phosphate) with a paracetamol + codeine + caffeine combination ( I g paracetamol + 16 mg codeine phosphate + 60 mg caffeine) for pain relief over 6 days two-stage bilateral lower third molar removal. Randomised crossover study (n=30) The ibuprofen combination produced significantly greater analgesia than the paracetamol combination, both on single-dose analysis of the and second days and on measures for days I , 2, 3 and 4 (P< 0.02 for all comparisons). Modaresi et al., 2006. Root canal therapy Tooth sensitivity levels Acetaminophen 300 mg + 20 mg codeine vs ibuprofen 200 mg Significantly lower tooth sensitivity levels (TSLs) were observed with the acetaminophen-codeine and ibuprofen groups, which was more significant in the ibuprofen group. Nautu et al., 2009. Systematic review of nine trials evaluating pain relief in post abdominal surgery pain VAS Codeine + paracetamol vs None of the studies found the combination of codeine + paracetamol to be superior to NSAIDs in controlling pain.