Takala-1 1999 10 Finland Cardiac Adult 247 Grip strength in kg Length of Unable to calculate from available 0.92a surgery stay data Abdominal Fatigue scored 1-10 Post Unable to calculate from available surgery discharge data Multiple trauma Ability to walk without Relative risk 0.55 [-1.18,0.91] NSf ARDS aid as proportion reduction Takala-2 1999 Europe 285 Grip strength in kg Length of Unable to calculate from available 0.27a stay data Fatigue scored 1-10 Post Unable to calculate from available discharge data 0.09 [-1.09,0.61] Ability to walk unaided Relative risk NSf as proportion reduction Gamrin 2000 19 Sweden Surgical and Adult 20 Muscle protein content 4 days Difference in +207 < 0.05c trauma ICU in % means FSR of muscle in % Difference in +33.00 0.01c means -0.29 Brunner 2012 23 Austria Sepsis Adult 38 Novel CIPNM score Day 14 Difference in NSd -0.10 Quantitative CIP score Difference in NSd -0.20 Semiquantitative Difference in NSd histopathological CIM means score Oxandrolone Demling 2003 13 USA Weight gain in kg burns 4 weeks Difference Adult in 3.00 [1.49,4.51] 45 < 0.05b requiring 3
Takala-1 1999 10 Finland Cardiac surgery Abdominal surgery Multiple trauma ARDS Adult 247 Grip strength in kg Length of stay Unable to calculate from available data 0.92a Fatigue scored 1-10 Post discharge Unable to calculate from available data Ability to walk without aid as proportion Relative risk reduction 0.55 [-1.18,0.91] NSf Takala-2 1999 Europe 285 Grip strength in kg Length of stay Unable to calculate from available data 0.27a Fatigue scored 1-10 Post discharge Unable to calculate from available data Ability to walk unaided as proportion Relative risk reduction 0.09 [-1.09,0.61] NSf Gamrin 2000 19 Sweden Surgical and trauma ICU Adult 20 Muscle protein content in % 4 days Difference in means +207 < 0.05c FSR of muscle in % Difference in means +33.00 0.01c Brunner 2012 23 Austria Sepsis Adult 38 Novel CIPNM score Day 14 Difference in -0.29 NSd Quantitative CIP score Difference in -0.10 NSd Semiquantitative histopathological CIM score Difference in means -0.20 NSd Oxandrolone Demling 2003 13 USA burns requiring 3 Adult 45 Weight gain in kg 4 weeks Difference in 3.00 [1.49,4.51] < 0.05b