Figures and table Table characteristics and total ARWMC scores 1: Subjects’ Subject group Controls p-value for p-value for APP PSEN1 PSEN1 control vs PSEN1 pre-codon PSEN1 200 200 200 vs post-codon 200 200 No. of subjects 25 13 18 21 Gender 13/12 6/7 9/9 10/11 M/F Age (y) at scan 53.5 53.8 43.5 51.1 0.0007* 0.4* Mean (sd) (10.6) (3.5) (7.0) (5.9) Disease duration 4.3 4.4 in years N/A 5.9 (5.6) 0.9* N/A (1.8) (2.5) Mean (sd) Age at onset 47.9 39.2 46.8 N/A 0.0005* N/A (5.3) (6.2) (6.1) Mean (sd) MRI scan Teslaa 16/9 12/1 12/6 16/5 0.5** 0.8** 1.5T/3T Proportion N/A 38% 22% 38% 0.3+ N/A carrying APOE4 allele No. of subjects with vascular 19 10 16 21 risk known Proportion with increased 0.06+ 1.0+ 21% 30% 0% 24% vascular risk score Total ARWMC score 0 0 0 3 <0.01§ <0.005§ Median Mean 0.9 1.8 1.1 3.6 (interquartile (0-1) (0-2) (0-1) (0-7) range) *T-test **Pearson chi-squared test exact test §Bootstrapped regression +Fisher’s a) One subject only (in the post-codon 200 group) had a 1.0T MRI scan, so was included in the PSEN1 1.5T group.
Figures and table Table 1: Subjects’ characteristics and total ARWMC scores Subject group Controls APP PSEN1 200 PSEN1 200 p-value for PSEN1 pre-codon 200 vs 200 p-value for control vs PSEN1 post-codon 200 No. of subjects 25 13 18 21 Gender M/F 13/12 6/7 9/9 10/11 Age (y) at scan Mean (sd) 53.5 (10.6) 53.8 (3.5) 43.5 (7.0) 51.1 (5.9) 0.0007* 0.4* Disease duration in years Mean (sd) N/A 5.9 (5.6) 4.3 (1.8) 4.4 (2.5) 0.9* N/A Age at onset Mean (sd) N/A 47.9 (5.3) 39.2 (6.2) 46.8 (6.1) 0.0005* N/A MRI scan Teslaa 1.5T/3T 16/9 12/1 12/6 16/5 0.5** 0.8** Proportion carrying APOE4 allele N/A 38% 22% 38% 0.3+ N/A No. of subjects with vascular risk known 19 10 16 21 Proportion with increased vascular risk score 21% 30% 0% 24% 0.06+ 1.0+ Total ARWMC score Median Mean (interquartile range) 0 0.9 (0-1) 0 1.8 (0-2) 0 1.1 (0-1) 3 3.6 (0-7) <0.01§ <0.005§ *T-test **Pearson chi-squared test +Fisher’s exact test §Bootstrapped regression a) One subject only (in the PSEN1 post-codon 200 group) had a 1.0T MRI scan, so was included in the 1.5T group.