Vehicle No information available Type of dressing No information available Remarks Method The test was not performed under GLP conditions. No method – description was provided. Group Number and Sex Dose Mortality of Animals mg/kg bw I Not stated 2000 None LD50 > 2000 mg/kg bw Signs of Toxicity - Local There were no signs of overt toxicity or effects on body weight gain. Signs of Toxicity - Systemic Not stated Effects in Organs No macroscopic changes in the principal organs and tissues were observed. Remarks Results A IUCLID summary of the test only was provided. – The test substance is of low toxicity via the dermal route. ECB (2000) 7.2.2 Acute toxicity dermal (Brake fluid DOT 4 type) – Brake fluid (DOT 4 type) No information available Species/Strain Rat (strain not stated) Vehicle No information available Type of dressing No information available Remarks Method No method description was provided. – Group Number and Sex Dose Mortality of Animals mg/kg bw I 5 per sex 2000 0/10 LD50 > 2000 mg/kg bw of Toxicity - Local Not stated Signs of Toxicity - Systemic There were no overt signs of toxicity. During the first week, some animals showed only a slight body weight gain and one female lost weight. All animals had gained weight by the end of the 14-day observation period. Effects in Organs necropsy revealed minor vascular congestion of the dermis at the site of application in two of the five males and three of the five females. Remarks Results A IUCLID summary of the test only was provided. – The test substance is of low toxicity via the dermal route. ECB (2000) 7.3. Acute toxicity - inhalation No study reports were provided by the notifier. 7.4. Irritation skin – 7.4.1 Irritation skin (Borate Ester C) –
Vehicle No information available Type of dressing No information available Remarks – Method The test was not performed under GLP conditions. No method description was provided. Group Number and Sex of Animals Dose mg/kg bw Mortality I Not stated 2000 None LD50 > 2000 mg/kg bw Signs of Toxicity - Local There were no signs of overt toxicity or effects on body weight gain. Signs of Toxicity - Systemic Not stated Effects in Organs No macroscopic changes in the principal organs and tissues were observed. Remarks – Results A IUCLID summary of the test only was provided. The test substance is of low toxicity via the dermal route. ECB (2000) 7.2.2 Acute toxicity – dermal (Brake fluid DOT 4 type) Brake fluid (DOT 4 type) No information available Species/Strain Rat (strain not stated) Vehicle No information available Type of dressing No information available Remarks – Method No method description was provided. Group Number and Sex of Animals Dose mg/kg bw Mortality I 5 per sex 2000 0/10 LD50 > 2000 mg/kg bw of Toxicity - Local Not stated Signs of Toxicity - Systemic There were no overt signs of toxicity. During the first week, some animals showed only a slight body weight gain and one female lost weight. All animals had gained weight by the end of the 14-day observation period. Effects in Organs necropsy revealed minor vascular congestion of the dermis at the site of application in two of the five males and three of the five females. Remarks – Results A IUCLID summary of the test only was provided. The test substance is of low toxicity via the dermal route. ECB (2000) 7.3. Acute toxicity - inhalation No study reports were provided by the notifier. 7.4. Irritation – skin 7.4.1 Irritation – skin (Borate Ester C)