N= 14,815 Outcome Difference in N if implemented Health Economic Impact QALY Economic impact Total Economic Impact risk between at 65% service on health service impact per on QALYS if control and cost per costs if person implemented treatment person or implemented day Primary Death at day 90 -10% -251 - - -$0.4m -$110m -$110m Secondary Severe -1272% -610 -$1,943 -$1m - - -$1m hypoglycaemia Received -9% -277 -$7 <-$0.1m - - <-$0.1m corticosteroid Change in -$1m intervention costs -$1m -$110m -$112m Totals Columns may not sum due to rounding. Negative values are savings in the calculations. ICU = intensive care unit. Health service/ Health Service or outcome cost Explanation and costing assumptions Reference Outcome per person or day No incremental service costs are expected to be saved. Patients who would have otherwise died are impaired with moderate disability WHO (2013). WHO methods and data sources for global burden of (estimated on age, APACHE II score and baseline characteristics). Many disease estimates 2000-2011. patients had respiratory or cardiovascular failure at baseline, and a high QALY: Death at day 90 APACHE II score. For conservatism, it is assumed that these patients would Wright et al. (2003) Long-term survival following intensive care: have otherwise had a severe form of disability (equivalent to 0.37, the average Subgroup analysis and comparison with the general population. WHO disability weight for stroke. Anaesthesia 58, pages 637–642. 4-year additional life expectancy based on Wright et al. 2003 risk score estimates (for age group, APACHE II score and diagnosis hazard group).
N= 14,815 Outcome Difference in risk between control and treatment N if implemented at 65% Health service cost per person or day Economic Impact on health service costs if implemented QALY impact per person Economic impact on QALYS if implemented Total Economic Impact Primary Death at day 90 -10% -251 - - -$0.4m -$110m -$110m Secondary Severe hypoglycaemia -1272% -610 -$1,943 -$1m - - -$1m Received corticosteroid -9% -277 -$7 <-$0.1m - - <-$0.1m Change in intervention costs Totals -$1m -$1m -$110m -$112m Columns may not sum due to rounding. Negative values are savings in the calculations. ICU = intensive care unit. Health Service or Outcome Health service/ outcome cost per person or day Explanation and costing assumptions Reference Death at day 90 QALY: No incremental service costs are expected to be saved. Patients who would have otherwise died are impaired with moderate disability (estimated on age, APACHE II score and baseline characteristics). Many patients had respiratory or cardiovascular failure at baseline, and a high APACHE II score. For conservatism, it is assumed that these patients would have otherwise had a severe form of disability (equivalent to 0.37, the average WHO disability weight for stroke. 4-year additional life expectancy based on Wright et al. 2003 risk score estimates (for age group, APACHE II score and diagnosis hazard group). WHO (2013). WHO methods and data sources for global burden of disease estimates 2000-2011. Wright et al. (2003) Long-term survival following intensive care: Subgroup analysis and comparison with the general population. Anaesthesia 58, pages 637–642.