Placebo 266 66.9 44.2 ±12.4 7 9 (Geretsegger et Paroxetine 20-30 Yes 6 T6 44 - 71.0± 5.9 No 3 - Yes al. 1995)() (Golden et al. Paroxetine CR 48.2 Yes 12 T12 212 63.2 40.7± 10.8 No - 49 Yes 2002)() Paroxetine IR 38.2 217 69.1 39.9± 11.4 - 47 Placebo 211 63.0 39.7± 10.8 - 17 (Goldstein et al. Duloxetine 40-120 No 8 T8 70 62.9 42.3± 10.8 No 14 13 Yes 2002)() Fluoxetine 20 33 57.6 39.7±10.5 3 7 Placebo 70 68.6 41.4±13.3 5 7 (Goldstein et al. Duloxetine 40 No 8 T8 86 56 41±10 No 15 15 Yes 2004)() Duloxetine 80 91 62 41±12 18 10 Paroxetine 20 87 64 40±13 7 7 Placebo 89 64 40±11 5 2 GSK Bupropion 300 Yes 8 T8 816 - - No 131 - Yes Bupropion study I GSK Bupropion 150-450 Yes 8 T8 801 - - No 64 16 Yes Bupropion trial Escitalopram 10-20 281 - - 22 22 II Venlafaxine 75-150 385 - - 19 15 Placebo 796 - - 32 32 GSK Paroxetine 30 Yes 8 T8 172 76.7 47.8 No 23 - Yes Paroxetine trial 1993
Placebo 266 66.9 44.2 ±12.4 7 9 (Geretsegger et al. 1995)() Paroxetine 20-30 Yes 6 T6 44 - 71.0± 5.9 No 3 - Yes (Golden et al. 2002)() Paroxetine CR Paroxetine IR Placebo 48.2 38.2 Yes 12 T12 212 217 211 63.2 69.1 63.0 40.7± 10.8 39.9± 11.4 39.7± 10.8 No - - - 49 47 17 Yes (Goldstein et al. 2002)() Duloxetine Fluoxetine Placebo 40-120 20 No 8 T8 70 33 70 62.9 57.6 68.6 42.3± 10.8 39.7±10.5 41.4±13.3 No 14 3 5 13 7 7 Yes (Goldstein et al. 2004)() Duloxetine Duloxetine Paroxetine Placebo 40 80 20 No 8 T8 86 91 87 89 56 62 64 64 41±10 41±12 40±13 40±11 No 15 18 7 5 15 10 7 2 Yes GSK Bupropion study I Bupropion 300 Yes 8 T8 816 - - No 131 - Yes GSK Bupropion II Bupropion Escitalopram Venlafaxine Placebo 150-450 10-20 75-150 Yes 8 T8 801 281 385 796 - - - - - - - - No 64 22 19 32 16 22 15 32 Yes GSK Paroxetine 1993 Paroxetine 30 Yes 8 T8 172 76.7 47.8 No 23 - Yes trial trial