and USA bias (exclusion criteria included dyspnoea, which resolved within 5 minutes (IHE 6/12) contraindications to CMR or after stopping the adenosine infusion. stress agent) Kirschbaum N=50 patients with stable angina Level IV SP-CMR - No serious AEs occurred. - et al. () and suspected CAD with normal Moderate risk of LVEF The bias Netherlands (IHE 6/12) (exclusion criteria included contraindications to CMR or contrast medium) Costa et al. () Level IV N=37 patients with suspected SP-CMR - No patients had serious AEs during CMR. 1 patient had CAD coronary USA Moderate risk of ICA + FFR spasm during FFR bias (exclusion criteria included measurements. (IHE 7.5/12) contraindications to CMR or stress agent) Bunce et al. () Level IV: N=35 consecutive patients SP-CMR - CMR was well tolerated with no AEs. - undergoing diagnostic ICA for the UK Moderate risk of investigation of angina bias (exclusion criteria included (IHE 6.5/12) contraindications to CMR or stress agent) - - - - - Dobutamine - Mordi et al. () Level IV N=82 patients with LBBB and an SP-CMR + - There were no major AEs. - intermediate PTP for CAD and LGE UK Low risk of bias typical features of angina (IHE 8.5/12) (exclusion criteria included contraindications to CMR, contrast medium or stress agent) Falcao et al. Level IV N=57 patients with suspected SP-CMR 2 patients had 1 patient had sustained ventricular - () CAD claustrophobia. tachycardia, and 2 had hypertension Moderate risk of resulting in interruption of the stress test. Brazil bias (exclusion criteria included morbid 2 patients refused to
and USA bias (IHE 6/12) (exclusion criteria included contraindications to CMR or stress agent) dyspnoea, which resolved within 5 minutes after stopping the adenosine infusion. Kirschbaum et al. () The Netherlands Level IV Moderate risk of bias (IHE 6/12) N=50 patients with stable angina and suspected CAD with normal LVEF (exclusion criteria included contraindications to CMR or contrast medium) SP-CMR - No serious AEs occurred. - Costa et al. () USA Level IV Moderate risk of bias (IHE 7.5/12) N=37 patients with suspected CAD (exclusion criteria included contraindications to CMR or stress agent) SP-CMR ICA + FFR - No patients had serious AEs during CMR. 1 patient had coronary spasm during FFR measurements. Bunce et al. () UK Level IV: Moderate risk of bias (IHE 6.5/12) N=35 consecutive patients undergoing diagnostic ICA for the investigation of angina (exclusion criteria included contraindications to CMR or stress agent) SP-CMR - CMR was well tolerated with no AEs. - - - - - - Dobutamine - Mordi et al. () UK Level IV Low risk of bias (IHE 8.5/12) N=82 patients with LBBB and an intermediate PTP for CAD and typical features of angina (exclusion criteria included contraindications to CMR, contrast medium or stress agent) SP-CMR + LGE - There were no major AEs. - Falcao et al. () Brazil Level IV Moderate risk of bias N=57 patients with suspected CAD (exclusion criteria included morbid SP-CMR 2 patients had claustrophobia. 2 patients refused to 1 patient had sustained ventricular tachycardia, and 2 had hypertension resulting in interruption of the stress test. -