Gerber et al. () Level III-2 N=144 patients Inclusion criteria: Intervention: Belgium Quality: 18.5/26 86 patients underwent complete Consecutive patients undergoing LGE-CMR for assessment of Full revascularisation revascularisation myocardial viability; with CAD and LVEF <35% who satisfied Moderate quality Comparator: 46 patients had medical therapy alone Felker’s criteria for ischemic cardiomyopathy. 12 had incomplete PCI Cohort study Incomplete PCI or medical Exclusion criteria: therapy alone Patients with non-ischemic cardiomyopathy; without cardiac Outcomes: Mean age: 65 ± 11 years catheterisation within 3 months before CMR; with significant valve disease (grade >2 mitral or aortic insufficiency or 3-year overall survival Male: 90.3% significant mitral or aortic stenosis); who had already been revascularised; life expectancy <1 year due to other Ethnicity: NR comorbidities; infarct complications Follow-up: median 3 years Schinkel et al. Level III-2 k=29 studies Inclusion criteria: Intervention: () Prospective studies in patients with chronic CAD who Quality: 2/11 N=3,640 patients Revascularisation The underwent revascularisation; 1 of the selected Poor quality Comparator: Netherlands techniques(dobutamine Echo, SPECT and PET) evaluated; results allowing assessment of sensitivity, specificity, PPV and Patient characteristics: NR Medical therapy NPV of techniques tested Outcomes: SR Exclusion criteria: Annualised mortality rates Techniques evaluated in patients who did not undergo revascularisation; with acute ischemic coronary syndromes; studies that did not allow assessment of sensitivity and specificity to predict improvement of regional LV function after revascularisation CABG = coronary artery bypass graft; CAD = coronary artery disease; CMR = cardiac magnetic resonance imaging; Echo = echocardiogram; LGE = late gadolinium enhancement; LVD = left ventricular dysfunction; LVEF = left ventricular ejection fraction; NPV = negative predictive value; NR = not reported; PCI = percutaneous coronary intervention; PET = positron emission tomography; PPV = positive predictive value; RCT = randomised controlled trial; SPECT= single-photon emission computed tomography; SR = systematic review
Gerber et al. () Belgium Cohort study Level III-2 Quality: 18.5/26 Moderate quality N=144 patients 86 patients underwent complete revascularisation 46 patients had medical therapy alone 12 had incomplete PCI Mean age: 65 ± 11 years Male: 90.3% Ethnicity: NR Follow-up: median 3 years Inclusion criteria: Consecutive patients undergoing LGE-CMR for assessment of myocardial viability; with CAD and LVEF <35% who satisfied Felker’s criteria for ischemic cardiomyopathy. Exclusion criteria: Patients with non-ischemic cardiomyopathy; without cardiac catheterisation within 3 months before CMR; with significant valve disease (grade >2 mitral or aortic insufficiency or significant mitral or aortic stenosis); who had already been revascularised; life expectancy <1 year due to other comorbidities; infarct complications Intervention: Full revascularisation Comparator: Incomplete PCI or medical therapy alone Outcomes: 3-year overall survival Schinkel et al. () The Netherlands SR Level III-2 Quality: 2/11 Poor quality k=29 studies N=3,640 patients Patient characteristics: NR Inclusion criteria: Prospective studies in patients with chronic CAD who underwent revascularisation; 1 of the selected techniques(dobutamine Echo, SPECT and PET) evaluated; results allowing assessment of sensitivity, specificity, PPV and NPV of techniques tested Exclusion criteria: Techniques evaluated in patients who did not undergo revascularisation; with acute ischemic coronary syndromes; studies that did not allow assessment of sensitivity and specificity to predict improvement of regional LV function after revascularisation Intervention: Revascularisation Comparator: Medical therapy Outcomes: Annualised mortality rates CABG = coronary artery bypass graft; CAD = coronary artery disease; CMR = cardiac magnetic resonance imaging; Echo = echocardiogram; LGE = late gadolinium enhancement; LVD = left ventricular dysfunction; LVEF = left ventricular ejection fraction; NPV = negative predictive value; NR = not reported; PCI = percutaneous coronary intervention; PET = positron emission tomography; PPV = positive predictive value; RCT = randomised controlled trial; SPECT= single-photon emission computed tomography; SR = systematic review