bolus and give it shape characteristics similar to those of time-intensity curves taken from clinical data. The objectives and deliverables using this phantom are: Objective Motivation Deliverable 1. Establish settings for the Standardization of Provide a profile for scanners participating in the ultrasound equipment so optimal clinical CEUS use. QIBA initiative for good clinical measurement This includes optimal microbubble imaging for made on various settings per scanner: quantification. This includes machines will provide nonlinear mode, highest the following: minimize similar results nondestructive MI, contrast agent destruction, analog/digital gain, maximize tissue cancellation, dynamic range avoid signal saturation, avoid (compression) acoustic shadowing. 2. Establish and validate Select one of several Provide recommended linearization scheme (native schemes presently being linearization scheme data vs empiric) evaluated for standardization 3. Select appropriate Select one (or more) of Provide list with quantification software several programs recommended presently available (or Quantification software develop our own) for standardization 4. Select appropriate indicator For standardization Provide recommended dilution model (e.g., indicator dilution model lognormal, LDRW) 5. Measure relative flow rate To determine the range of Provide a validated range in 8, 4, 2, 1 mm tubing for flow measurements that can of flow rates and vessel rates 10-1000ml/min (lower be made accurately with sizes that CEUS can make flow rates in the smaller tubes CEUS – which clinical accurate measurements and higher in the larger) situations can CEUS be appropriate for 6. Compare CEUS results with Determine the accuracy Provide accuracy of CEUS volumetric flow of CEUS for flow flow rates compared to measurements (and Doppler) measurements other standards for validation Timeline Duration Activity
bolus and give it shape characteristics similar to those of time-intensity curves taken from clinical data. The objectives and deliverables using this phantom are: Objective Motivation Deliverable 1. Establish settings for the scanners participating in the QIBA initiative for good microbubble imaging for quantification. This includes the following: minimize contrast agent destruction, maximize tissue cancellation, avoid signal saturation, avoid acoustic shadowing. Standardization of ultrasound equipment so clinical measurement made on various machines will provide similar results Provide a profile for optimal clinical CEUS use. This includes optimal settings per scanner: nonlinear mode, highest nondestructive MI, analog/digital gain, dynamic range (compression) 2. Establish and validate linearization scheme (native data vs empiric) Select one of several schemes presently being evaluated for standardization Provide recommended linearization scheme 3. Select appropriate quantification software Select one (or more) of several programs presently available (or develop our own) for standardization Provide list with recommended Quantification software 4. Select appropriate indicator dilution model (e.g., lognormal, LDRW) For standardization Provide recommended indicator dilution model 5. Measure relative flow rate in 8, 4, 2, 1 mm tubing for flow rates 10-1000ml/min (lower flow rates in the smaller tubes and higher in the larger) To determine the range of measurements that can be made accurately with CEUS – which clinical situations can CEUS be appropriate for Provide a validated range of flow rates and vessel sizes that CEUS can make accurate measurements 6. Compare CEUS results with volumetric flow measurements (and Doppler) for validation Determine the accuracy of CEUS for flow measurements Provide accuracy of CEUS flow rates compared to other standards Timeline Duration Activity