(Blier et al. Mirtazapine 30-45 No 6+16 T6 21 23.8 46 ± 9 No 5 11 Yes 2009)() Paroxetine 20-30 19 52.6 40 ± 12 8 5 (Bondareff et Sertraline 96 ± 41 Yes 12 T12 104 60.6 67.8 ± 6.0 No 21 5 Yes al. 2000)() (Bose et al. Escitalopram 14 No 12 T12 130 59 68.1± 6.7 No 10 - Yes 2008)() Placebo 134 60 68.5±7.1 17 - (Boyer et al. Sertraline 79.17 No 8 T8 140 61.4 39.87 No 10 - No 2000)() (Boyer et al. Desvenlafaxine 50 No 8 T8 164 70 44±14 No 13 - Yes 2008)() Desvenlafaxine 100 158 71 46±13 14 Placebo 161 68 46±12 7 (Brannan et al. Duloxetine 60 Yes 7 T7 141 68.1 40.8±13.5 No 15 - Yes 2005)() Placebo 141 62.4 40.3±13.5 9 - (Brecht et al. Duloxetine 60 No 8 T8 162 75.9 48.1 No 6 - Yes 2007)() Placebo 165 71.5 52.3 3 - (Bremner et al. Mirtazapine 22 No 6 T6 50 60 39 No - 23 Yes 1995)() Placebo 50 70 37 - 11 Brown (2005)() Citalopram 20-60 No 12 T12 41 80.5 40.4± 10.8 No 9 - No Placebo 41 80.5 42.9± 10.1 13 - (Brown et al. Sertraline 117.7±58.5 No 8 T8 112 69.6 42.3± 12.8 No 27 11 Yes 1995)() (Burke et al. Citalopram 40 Yes 8 T8 125 62 40.0±11.5 No 11 - Yes 2002)() Escitalopram 10 118 70 40.7±12.3 10 -
(Blier et al. 2009)() Mirtazapine Paroxetine 30-45 20-30 No 6+16 T6 21 19 23.8 52.6 46 ± 9 40 ± 12 No 5 8 11 5 Yes (Bondareff et al. 2000)() Sertraline 96 ± 41 Yes 12 T12 104 60.6 67.8 ± 6.0 No 21 5 Yes (Bose et al. 2008)() Escitalopram Placebo 14 No 12 T12 130 134 59 60 68.1± 6.7 68.5±7.1 No 10 17 - - Yes (Boyer et al. 2000)() Sertraline 79.17 No 8 T8 140 61.4 39.87 No 10 - No (Boyer et al. 2008)() Desvenlafaxine Desvenlafaxine Placebo 50 100 No 8 T8 164 158 161 70 71 68 44±14 46±13 46±12 No 13 14 7 - Yes (Brannan et al. 2005)() Duloxetine Placebo 60 Yes 7 T7 141 141 68.1 62.4 40.8±13.5 40.3±13.5 No 15 9 - - Yes (Brecht et al. 2007)() Duloxetine Placebo 60 No 8 T8 162 165 75.9 71.5 48.1 52.3 No 6 3 - - Yes (Bremner et al. 1995)() Mirtazapine Placebo 22 No 6 T6 50 50 60 70 39 37 No - - 23 11 Yes Brown (2005)() Citalopram Placebo 20-60 No 12 T12 41 41 80.5 80.5 40.4± 10.8 42.9± 10.1 No 9 13 - - No (Brown et al. 1995)() Sertraline 117.7±58.5 No 8 T8 112 69.6 42.3± 12.8 No 27 11 Yes (Burke et al. 2002)() Citalopram Escitalopram 40 10 Yes 8 T8 125 118 62 70 40.0±11.5 40.7±12.3 No 11 10 - - Yes