Attachment 1 The Draize Scale (Draize, 1959) for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm 4 and extending beyond area of exposure) The Draize scale (Draize 1944) for evaluation of eye reactions is as follows: et al., CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly slight 25% to 50% 2 visible Easily visible translucent areas, details 2 mild 50% to 75% 3 of iris slightly obscure Opalescent no details of iris 3 visible, size of pupil barely discernible Greater than 75% 4 moderate Opaque, iris invisible 4 severe area around eye 1 Any swelling slight normal Vessels definitely slight injected above normal Any amount different Obvious swelling with from normal More diffuse, deeper partial eversion of lids mild slight crimson red with Discharge with Swelling with lids individual vessels not moistening of lids and easily discernible adjacent hairs mod. mod. Swelling with lids severe Diffuse beefy red Discharge with to moistening of lids and completely closed 4 severe severe hairs and considerable IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Attachment 1 The Draize Scale (Draize, 1959) for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema of area well- 2 defined by definite raising Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm 4 and extending beyond area of exposure) The Draize scale (Draize et al., 1944) for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible Easily visible translucent areas, details of iris slightly obscure slight 25% to 50% 2 2 mild 50% to 75% 3 Opalescent no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 1 slight severe Any swelling normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed slight mild mod. 4 severe Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye slight mod. severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe