9.Overview of Methodology Coordination Centre A national coordination centre (NCC) will be established to plan, monitor the recruitment and examinations, manage the data and take responsibility of the analysis and reporting of the results. This will be at the Host Institution, Anglia Ruskin University, in Cambridge. Ethics The NEHS management team will seek ethics approval for the NEHS via the Health Research Authorities for England and the devolved nations. Each participant will be required to sign a consent form that outlines the aims, significance and methodology of the NEHS. The NEHS will adhere to the tenets of the Declaration of Helsinki and all privacy requirements will be met. Sample population The NEHS will involve a representative sample of people from all regions of the United Kingdom. Each participant enrolled in the NEHS will undergo a simple eye examination and complete a standardised general questionnaire. Interviews and examinations will be conducted at each testing site. All examinations will be conducted by trained eye NEHS and local staff. Sampling Frame and Sample Size Calculation [national survey] The national survey will adopt a multi-stage stratified probability sampling design, common to the Health Survey England series. The sampling frame will be the small user Postcode Address File (PAF). The very small proportion of households living at addresses not on PAF (less than 1%) will not be covered. Total Sample size = 24,294 adults aged 50 years and older to give precision in % blind in UK, assuming: Blindness prevalence of 0.4% Precision in MSVI in each of the 4 countries, assuming 3.5% (prevalence assumption based on GBD model*) Design effect of 1.5 487 clusters of 50 people selected by stratified (1.country 2. ethnicity in England then 3. Index of Multiple Deprivation). 349 in England, 46 in each of the other countries (oversampling to achieve precision in MSVI %). Random sampling with PPS methods using UK postcode sampling frame. A random sample of care homes will be selected for the Survey of care homes in the UK. * this prevalence is on estimates for the UK from the Global Vision Database- see Bourne RRA, Jonas JB, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Parodi M, Pesudovs K, Price H, White RA,
9.Overview of Methodology Coordination Centre A national coordination centre (NCC) will be established to plan, monitor the recruitment and examinations, manage the data and take responsibility of the analysis and reporting of the results. This will be at the Host Institution, Anglia Ruskin University, in Cambridge. Ethics The NEHS management team will seek ethics approval for the NEHS via the Health Research Authorities for England and the devolved nations. Each participant will be required to sign a consent form that outlines the aims, significance and methodology of the NEHS. The NEHS will adhere to the tenets of the Declaration of Helsinki and all privacy requirements will be met. Sample population The NEHS will involve a representative sample of people from all regions of the United Kingdom. Each participant enrolled in the NEHS will undergo a simple eye examination and complete a standardised general questionnaire. Interviews and examinations will be conducted at each testing site. All examinations will be conducted by trained eye NEHS and local staff. Sampling Frame and Sample Size Calculation [national survey] The national survey will adopt a multi-stage stratified probability sampling design, common to the Health Survey England series. The sampling frame will be the small user Postcode Address File (PAF). The very small proportion of households living at addresses not on PAF (less than 1%) will not be covered. Total Sample size = 24,294 adults aged 50 years and older to give precision in % blind in UK, assuming: Blindness prevalence of 0.4% Precision in MSVI in each of the 4 countries, assuming 3.5% (prevalence assumption based on GBD model*) Design effect of 1.5 487 clusters of 50 people selected by stratified (1.country 2. ethnicity in England then 3. Index of Multiple Deprivation). 349 in England, 46 in each of the other countries (oversampling to achieve precision in MSVI %). Random sampling with PPS methods using UK postcode sampling frame. A random sample of care homes will be selected for the Survey of care homes in the UK. * this prevalence is on estimates for the UK from the Global Vision Database- see Bourne RRA, Jonas JB, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Parodi M, Pesudovs K, Price H, White RA,