Tramadol and sertraline 75 yrs, female 50mg daily Sertraline 50mg unknown confusion, myoclonic jerks Sertraline discontinued and symptoms 25 remitted after a few days. (single dose given) 42 yrs, female 300mg daily at time of Sertraline 100mg daily Unknown Tachycardia, altered mental state, Symptoms resolved 24–36 hours after 26 diagnosis (patient had disturbances. stopping tramadol and reducing sertraline to been self increasing 50mg daily. the dose). Symptoms started 3 weeks after tramadol initiated. 88 yrs, female 100mg daily, increased Sertraline 50mg daily, Confusion, alterations in cognitive function, Sertraline withdrawn and tramadol dose 27 to 400mg daily. Started increased to 100mg daily. tremor, co-ordination problems, muscle reduced to 200mg daily. Patient recovered 10 days before weakness. after 2 weeks. symptom onset. Others (not listed) 55 yrs, male Dose unknown, Sertraline , dose unknown, 1 Trazodone Fever, fine tremors, myoclonic jerks Recovered within 24 hours after medicines 28 increased over 4-5 year stopped. days prior to admission
Tramadol and sertraline 75 yrs, female 50mg daily Sertraline 50mg (single dose given) unknown confusion, myoclonic jerks Sertraline discontinued and symptoms remitted after a few days. 25 42 yrs, female 300mg daily at time of diagnosis (patient had been self increasing the dose). Symptoms started 3 weeks after tramadol initiated. Sertraline 100mg daily Unknown Tachycardia, altered mental state, disturbances. Symptoms resolved 24–36 hours after stopping tramadol and reducing sertraline to 50mg daily. 26 88 yrs, female 100mg daily, increased to 400mg daily. Started 10 days before symptom onset. Sertraline 50mg daily, increased to 100mg daily. Others (not listed) Confusion, alterations in cognitive function, tremor, co-ordination problems, muscle weakness. Sertraline withdrawn and tramadol dose reduced to 200mg daily. Patient recovered after 2 weeks. 27 55 yrs, male Dose unknown, increased over 4-5 days prior to admission Sertraline , dose unknown, 1 year Trazodone Fever, fine tremors, myoclonic jerks Recovered within 24 hours after medicines stopped. 28