none Morphological findings: OECD TG 401 Test method: > 5 000 mg/kg LD50: the test substance was of very low acute oral Result: toxicity in rats Dermal Toxicity (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 rat/Fischer 344 Species/strain: 5/sex Number/sex of animals: 14 days Observation period: single dose at 1.89 mL/kg under occlusive dressing Method of administration: for 24 hours none Clinical observations: none Mortality: minor vascular congestion of the dermis in 2 male Morphological findings: and 3 female rats EEC Method B3 Test method: > 2 000 mg/kg LD50: the test substance was of low acute dermal toxicity Result: in rats Shell Brake Fluid Dot 4 Super rat/Fischer 344 Species/strain: 5/sex Number/sex of animals: 14 days Observation period: under occlusive dressing for 24 hours Method of administration: none Clinical observations:
Morphological findings: none Test method: OECD TG 401 LD50: > 5 000 mg/kg Result: the test substance was of very low acute oral toxicity in rats Dermal Toxicity (Gardner, 1990; Gardner, 1992) Shell Brake Fluid Dot 4 Species/strain: rat/Fischer 344 Number/sex of animals: 5/sex Observation period: 14 days Method of administration: single dose at 1.89 mL/kg under occlusive dressing for 24 hours Clinical observations: none Mortality: none Morphological findings: minor vascular congestion of the dermis in 2 male and 3 female rats Test method: EEC Method B3 LD50: > 2 000 mg/kg Result: the test substance was of low acute dermal toxicity in rats Shell Brake Fluid Dot 4 Super Species/strain: rat/Fischer 344 Number/sex of animals: 5/sex Observation period: 14 days Method of administration: under occlusive dressing for 24 hours Clinical observations: none