C9, C10 DIDP No in vivo carcinogenicity studies are available. Rats: LOAEL = 120 mg/kg bw/d (f): liver weight. ↑ NOAEL = 60 mg/kg bw/d. Positive in 1 of 2 in vitro cell transformation assays. High doses: liver and kidney weight; nephropathy (m) ↑ PP noted. Dog: LOAEL=75 mg/kg bw/d: liver weight (low ↑ reliability study) C10 DIUP No data are available No in vivo carcinogenicity studies are available. Negative in an in vitro cell transformation assay. C11 DUP No data are available Rat: LOAEL = 1145 mg/kg bw/d: liver weight. ↑ NOAEL = 282 mg/kg bw/d. High doses: liver and kidney weights. PP noted. ↑ C12-rich DITDP No data are available. No data are available. Rats: LOAEL = 50 mg/kg bw/d, liver weight, ↑ C13 DTDP No data are available hypertrophy of centrilobular hepatocytes, body weight ↓ gain. NOAEL = 10 mg/kg bw/d. High doses: liver and kidney effects. PP not noted. f female; m - male; PP peroxisome proliferation – –
C9, C10 DIDP Rats: LOAEL = 120 mg/kg bw/d (f): ↑ liver weight. NOAEL = 60 mg/kg bw/d. High doses: ↑ liver and kidney weight; nephropathy (m) PP noted. Dog: LOAEL=75 mg/kg bw/d: ↑ liver weight (low reliability study) No in vivo carcinogenicity studies are available. Positive in 1 of 2 in vitro cell transformation assays. C10 DIUP No data are available No in vivo carcinogenicity studies are available. Negative in an in vitro cell transformation assay. C11 DUP Rat: LOAEL = 1145 mg/kg bw/d: ↑ liver weight. NOAEL = 282 mg/kg bw/d. High doses: ↑ liver and kidney weights. PP noted. No data are available C12-rich DITDP No data are available. No data are available. C13 DTDP Rats: LOAEL = 50 mg/kg bw/d, ↑ liver weight, hypertrophy of centrilobular hepatocytes, ↓ body weight gain. NOAEL = 10 mg/kg bw/d. High doses: liver and kidney effects. PP not noted. No data are available f – female; m - male; PP – peroxisome proliferation