Parallel To test the 41 adults (56% male, All subjects Compliance and Baseline Non-significant Mild GI side Uusitupa 1992 average age 45y in consumed AHA dietary intake by characteristics decreases in total effects in both effects control group and 50y Step 1 diet. Oat 4d food records and dietary cholesterol, groups, more of -glucan-rich in oat group). Subjects bran (10.3g during run-in and intake during and HDL-C. frequently in the oat bran in had or wheat at 4 and 8wks. intervention oat group. hypercholesterolaemia bran given as Blood lipids were well adults and were recruited supplement, measured matched. consuming a from a previous trial. 36 usually consumed enzymatically, low-fat, completed the study with juice, LDL calculated. diet. (20 in oat group, 16 in porridge, yoghurt Statistical analysis control). and dessert. by variance. Actual -glucan intake approx. 7g in 60% of subjects. Subgroup analyses based on ApoE phenotype. 4wk run-in, 8wk intervention period. Parallel To test the effect 256 healthy All subjects on Dietary intake by Groups appear Non-significant LDL-C effects Van Horn 1988 of adding participants with normal 2 of AHA diet, 3 day food record well matched at decrease in total were similar to oatmeal to a lipids (64% male, with oat group every 4 weeks. baseline. Dietary cholesterol. total cholesterol, diet on 30-65y). 236 completed adding 56g of Unclear method of intake well but unable to be serum study. oatmeal per day to lipid matched during included in cholesterol diet. Subgroup measurement, intervention. meta-analysis concentration. analyses baseline LDL-C calculated. due to ambiguity cholesterol Statistical analysis in reporting. concentration and by t-test. HDL-C gender. appeared to 4wk run-in (on increase in both AHA diet) then groups, but was 4wk test period. also unsuitable for inclusion.
Uusitupa 1992 Parallel To test the effects of -glucan-rich oat bran in adults consuming a low-fat, diet. 41 adults (56% male, average age 45y in control group and 50y in oat group). Subjects had hypercholesterolaemia and were recruited from a previous trial. 36 completed the study (20 in oat group, 16 in control). All subjects consumed AHA Step 1 diet. Oat bran (10.3g or wheat bran given as supplement, usually consumed with juice, porridge, yoghurt and dessert. Actual -glucan intake approx. 7g in 60% of subjects. Subgroup analyses based on ApoE phenotype. 4wk run-in, 8wk intervention period. Compliance and dietary intake by 4d food records during run-in and at 4 and 8wks. Blood lipids measured enzymatically, LDL calculated. Statistical analysis by variance. Baseline characteristics and dietary intake during intervention were well matched. Non-significant decreases in total cholesterol, and HDL-C. Mild GI side effects in both groups, more frequently in the oat group. Van Horn 1988 Parallel To test the effect of adding oatmeal to a diet on serum cholesterol concentration. 256 healthy participants with normal lipids (64% male, 30-65y). 236 completed study. All subjects on 2 of AHA diet, with oat group adding 56g of oatmeal per day to diet. Subgroup analyses baseline cholesterol concentration and gender. 4wk run-in (on AHA diet) then 4wk test period. Dietary intake by 3 day food record every 4 weeks. Unclear method of lipid measurement, LDL-C calculated. Statistical analysis by t-test. Groups appear well matched at baseline. Dietary intake well matched during intervention. Non-significant decrease in total cholesterol. LDL-C effects were similar to total cholesterol, but unable to be included in meta-analysis due to ambiguity in reporting. HDL-C appeared to increase in both groups, but was also unsuitable for inclusion.