Parker et Unclear risk (no Unclear risk (no Participants: 6.3% (low risk) No (unclear No (low Unclear risk (Reported National Heart al. (1990) description of description of low risk risk) risk) that creatinine, Foundation of method of method of potassium, calcium Australia, Royal Providers: low sequence concealment of and magnesium were Perth Hospital risk generation) allocation, unchanged but did not Medical stratified for age, report specific results. Research Outcome BMI, BP, alcohol HDL not separately Foundation (low assessors: consumption) reported for different risk) unclear risk sodium levels) Summary Citation Study Population Intervention Outcomes Sample Intervention Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question Parijs et II Adult (mean Participants consumed a Blood pressure 17 4 Low sodium period: Mean (supine and al (1973), age: 41.2 + regular diet and took 4 (outpatient 92.8 + 41.8 difference standing, Belgium 8.21 years), placebo tablets/day for a values only mmol/24hr between low measured with 2 -4 week run-in period. available sodium period office and [] Normal sodium study hypertension They were then randomly for n=15 and normal home) period: 191.1 + assigned to one of four sodium period : 61.2 mmol/24hr groups: in low Supine: Home BP not sodium, (p<0.0005) 1. Regular diet + placebo able to be placebo calculated due 2. moderate sodium to insufficient restriction + placebo
Parker et al. (1990) Unclear risk (no description of method of sequence generation) Unclear risk (no description of method of concealment of allocation, stratified for age, BMI, BP, alcohol consumption) Participants: low risk Providers: low risk Outcome assessors: unclear risk 6.3% (low risk) No (unclear risk) No (low risk) Unclear risk (Reported that creatinine, potassium, calcium and magnesium were unchanged but did not report specific results. HDL not separately reported for different sodium levels) National Heart Foundation of Australia, Royal Perth Hospital Medical Research Foundation (low risk) Summary Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results Parijs et al (1973), Belgium [] study II Adult (mean age: 41.2 + 8.21 years), with hypertension Participants consumed a regular diet and took 4 placebo tablets/day for a 2 -4 week run-in period. They were then randomly assigned to one of four groups: 1. Regular diet + placebo 2. moderate sodium restriction + placebo Blood pressure (supine and standing, measured office and home) Home BP not able to be calculated due to insufficient 17 (outpatient values only available for n=15 in low sodium, placebo 4 Low sodium period: 92.8 + 41.8 mmol/24hr Normal sodium period: 191.1 + 61.2 mmol/24hr (p<0.0005) Mean difference between low sodium period and normal sodium period : Supine: