2. Clinical Identification of Guidelines for clinicians for the . Aug 2012 practice individuals at risk for evaluation of patients for Lynch guidelines Lynch syndrome using Syndrome targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline 3. Study of Tumor Mismatch Repair Endometrial cancers from 702 . Jan 2014 diagnostic Immunohistochemistry patients recruited into the accuracy and DNA MLH1 Australian National Endometrial Methylation Testing of Cancer Study (ANECS) were Patients With tested for MMR protein Endometrial Cancer expression using Diagnosed at Age immunohistochemistry (IHC) and Younger Than 60 Years for MLH1 gene promoter Optimizes Triage for methylation in MLH1-deficient Population-Level cases. Germline Mismatch Repair Gene Mutation Testing
2. Clinical practice guidelines Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer joint practice guideline Guidelines for clinicians for the evaluation of patients for Lynch Syndrome . Aug 2012 3. Study of diagnostic accuracy Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing Endometrial cancers from 702 patients recruited into the Australian National Endometrial Cancer Study (ANECS) were tested for MMR protein expression using immunohistochemistry (IHC) and for MLH1 gene promoter methylation in MLH1-deficient cases. . Jan 2014