OLOA 200 Capped Polybutylene Oxide RS 4999 was of Result: very low acute oral toxicity to the rat. 9.1.2 Oral Toxicity (The Toxicology Research Laboratory 1997f) OLOA 2509H Test Substance: Rat/Fischer 344 Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A single-dose, by gavage, of neat test substance at Method of administration: 5000 mg/kg bw One male had faecal soiling of the perineum on the day Clinical observations: of dosing had resolved by day 2 Nil Mortality: No treatment related abnormalities observed Morphological findings: OECD TG 401 - Limit Test Test method: > 5000 mg/kg LD50: OLOA was of very low acute oral toxicity to the Result: rat. 9.1.2.1 Dermal Toxicity (Chevron Environmental Health and Toxicology 1978a) OLOA 200 Capped Polybutylene Oxide RS 4999 Test Substance: Rabbits/New Zealand White Species/strain: 6/treatment group; 6/control group. Number/sex of animals: 14 days Observation period: A single, 24 hour occlusive application of neat test substance Method of administration: (viscous yellow liquid) at 5000 mg/kg to intact skin (3 rabbits) or abraded skin (3 rabbits). Not stated. Test method: Nil Mortality:
Result: OLOA 200 Capped Polybutylene Oxide RS 4999 was of very low acute oral toxicity to the rat. 9.1.2 Oral Toxicity (The Toxicology Research Laboratory 1997f) Test Substance: OLOA 2509H Species/strain: Rat/Fischer 344 Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A single-dose, by gavage, of neat test substance at 5000 mg/kg bw Clinical observations: One male had faecal soiling of the perineum on the day of dosing had resolved by day 2 Mortality: Nil Morphological findings: No treatment related abnormalities observed Test method: OECD TG 401 - Limit Test LD50: > 5000 mg/kg Result: OLOA was of very low acute oral toxicity to the rat. 9.1.2.1 Dermal Toxicity (Chevron Environmental Health and Toxicology 1978a) Test Substance: OLOA 200 Capped Polybutylene Oxide RS 4999 Species/strain: Rabbits/New Zealand White Number/sex of animals: 6/treatment group; 6/control group. Observation period: 14 days Method of administration: A single, 24 hour occlusive application of neat test substance (viscous yellow liquid) at 5000 mg/kg to intact skin (3 rabbits) or abraded skin (3 rabbits). Test method: Not stated. Mortality: Nil