All animals showed bodyweight gain during the study. The Comment: pelvic dilation obaserved was a common spontaneous finding, therefore, is considered to be not treatment related. >2000 mg/kg LD50: the notified chemical was of low acute oral toxicity in rats Result: 9.1.2 Dermal Toxicity (Noakes, Species/strain: 5/sex Number/sex of animals: 14 days Observation period: A single dermal dose of 2000 mg/kg (moistened with Method of administration: deionised water) was applied under an occlusive dressing for 24 hours. OECD TG 402 (limit test) Test method: None Mortality: Black staining of application sites were noted in all animals Clinical observations: which prevented accurate evaluation of erythema for up to 6 days. All female animals had black staining of the tail/skin and one had scabs at the application site between days 3 and 7. Microscopic investigation was not conducted in the study. Morphological findings: All but one animal gained weight during the study. Comment: Except for scabbing in one female, no sign of irritation was observed in all animals >2000 mg/kg LD50: the notified chemical was of low dermal toxicity in rats Result: 9.1.3 Inhalation Toxicity No report on inhalation toxicity was provided. 9.1.4 Skin Irritation (Noakes,
Comment: All animals showed bodyweight gain during the study. The pelvic dilation obaserved was a common spontaneous finding, therefore, is considered to be not treatment related. LD50: >2000 mg/kg Result: the notified chemical was of low acute oral toxicity in rats 9.1.2 Dermal Toxicity (Noakes, Species/strain: Number/sex of animals: 5/sex Observation period: 14 days Method of administration: A single dermal dose of 2000 mg/kg (moistened with deionised water) was applied under an occlusive dressing for 24 hours. Test method: OECD TG 402 (limit test) Mortality: None Clinical observations: Black staining of application sites were noted in all animals which prevented accurate evaluation of erythema for up to 6 days. All female animals had black staining of the tail/skin and one had scabs at the application site between days 3 and 7. Morphological findings: Microscopic investigation was not conducted in the study. Comment: All but one animal gained weight during the study. Except for scabbing in one female, no sign of irritation was observed in all animals LD50: >2000 mg/kg Result: the notified chemical was of low dermal toxicity in rats 9.1.3 Inhalation Toxicity No report on inhalation toxicity was provided. 9.1.4 Skin Irritation (Noakes,