abnormalities Sun and Ng () 64% To perform an SR and Search period: ECG-gating using ICA: DS cut-off (7/11) of the diagnostic ≥64-slice CTCA: at 50% Australia January 2008 to December 2011 value of prospective k=14 Good gating CTCA compared with Databases searched: quality with ICA in the diagnosis of CAD low risk of Medline, PubMed, EMBASE and the Cochrane Library databases bias Inclusion criteria: Patients with suspected or Studies that included at least 10 patients with suspected or known CAD for known CAD evaluation of CAD, with >50% lumen stenosis defined as the cut-off criterion; Analysis at patient, vessel assessment of diagnostic value of prospective ECG-gating 64- or more-slice CTCA and segment level in CAD must be addressed at either patient-based, vessel-based or segment-based analysis when compared with ICA in terms of sensitivity, specificity, PPV and (NPV; the absolute number of true-positive, true-negative, false-positive and results were available or could be derived from available data; the effective dose of prospective ECG-gating protocols was reported in each study Exclusion criteria: Studies with patients after treatment of CABG or PCI; potential duplication or overlapping data Van Brabandt et 36% HTA summarising the Search period: 64-slice CTCA: k=9 ICA: DS cut-off current evidence supporting al. () (4/11) at 50% Studies published after those included in the SR by Abdulla et al. () the use of multislice CTCA Belgium Moderate as a diagnostic aid in 1 January 2007 to 10 March 2008 quality with patients suspected for CAD a moderate Databases searched: risk of bias Medline (through PubMed), EMBASE and SUMSearch Patients with suspected Inclusion criteria: CAD SRs and diagnostic studies that enrolled at least 30 patients with proven or Analysis at patient level suspected CAD, using 64-(or higher)slice CTCA compared with ICA as the reference to identify significant stenosis; that provided per-patient data on native
abnormalities Sun and Ng () Australia 64% (7/11) Good quality with low risk of bias To perform an SR and of the diagnostic value of prospective CTCA compared with ICA in the diagnosis of CAD Patients with suspected or known CAD Analysis at patient, vessel and segment level Search period: January 2008 to December 2011 Databases searched: Medline, PubMed, EMBASE and the Cochrane Library databases Inclusion criteria: Studies that included at least 10 patients with suspected or known CAD for evaluation of CAD, with >50% lumen stenosis defined as the cut-off criterion; assessment of diagnostic value of prospective ECG-gating 64- or more-slice CTCA in CAD must be addressed at either patient-based, vessel-based or segment-based analysis when compared with ICA in terms of sensitivity, specificity, PPV and (NPV; the absolute number of true-positive, true-negative, false-positive and results were available or could be derived from available data; the effective dose of prospective ECG-gating protocols was reported in each study Exclusion criteria: Studies with patients after treatment of CABG or PCI; potential duplication or overlapping data ECG-gating using ≥64-slice CTCA: k=14 ICA: DS cut-off at 50% Van Brabandt et al. () Belgium 36% (4/11) Moderate quality with a moderate risk of bias HTA summarising the current evidence supporting the use of multislice CTCA as a diagnostic aid in patients suspected for CAD Patients with suspected CAD Analysis at patient level Search period: Studies published after those included in the SR by Abdulla et al. () 1 January 2007 to 10 March 2008 Databases searched: Medline (through PubMed), EMBASE and SUMSearch Inclusion criteria: SRs and diagnostic studies that enrolled at least 30 patients with proven or suspected CAD, using 64-(or higher)slice CTCA compared with ICA as the reference to identify significant stenosis; that provided per-patient data on native 64-slice CTCA: k=9 ICA: DS cut-off at 50% gating