perfluorohexane sulfonate, perfluorooctane sulfonate and perfluoroctanoate of 96% 99% at 10% and 100% physiological – albumin concentrations compared to 71% and 93% albumin binding of perfluorobutane sulfonate at 10% and 100% physiological albumin concentrations, respectively. There is insufficient data in the study report to ascertain the significance or otherwise of the difference in the values of the percent binding of the four test materials to human albumin. The percent protein binding of perfluorobutane sulfonate (10 g/mL equivalent to 10 ppm) to human-derived gamma globulin, alpha- globulin, fibrinogen, alpha-2-macroglobulin, transferrin and beta lipoproteins (10% or 100% physiological concentration of the protein) is no more than 11% - with the percent binding ranges from less than 0.1% for binding to transferin to 11.3% for binding to alpha-2-macroglobulin. At concentrations of up to 100 ppm (equivalent to 100 of g/mL) the test material, the data in Table 4.5 shows the percent binding of perfluorobutane sulfonate in rat, human and monkey serum is typically greater than 98%. At perfluorobutane sulfonate concentration of 250 ppm and 500 ppm (equivalent to 250 g/mL and 500 the percent binding of the test material in rat, g/mL) human and monkey serum ranged from 85% - 94%. The slightly lower value of the percent of perfluorobutane sulfonate bound to rat, human and monkey serum at concentrations of the test material above 100 ppm compared to below 100 ppm is suggestive of a saturation of the binding above 100 ppm. Conclusion: High levels of binding of perfluorobutane sulfonate to human albumin (94% binding at 100% physiological concentrations of albumin) and an apparent saturated binding of the test material to albumin at concentrations of perflurobutane sulfonate above 100 ppm 250 ppm in rat, human and monkey serum was observed – in this study.
perfluorohexane sulfonate, perfluorooctane sulfonate and perfluoroctanoate of 96% – 99% at 10% and 100% physiological albumin concentrations compared to 71% and 93% albumin binding of perfluorobutane sulfonate at 10% and 100% physiological albumin concentrations, respectively. There is insufficient data in the study report to ascertain the significance or otherwise of the difference in the values of the percent binding of the four test materials to human albumin. The percent protein binding of perfluorobutane sulfonate (10 g/mL equivalent to 10 ppm) to human-derived gamma globulin, alpha- globulin, fibrinogen, alpha-2-macroglobulin, transferrin and beta lipoproteins (10% or 100% physiological concentration of the protein) is no more than 11% - with the percent binding ranges from less than 0.1% for binding to transferin to 11.3% for binding to alpha-2-macroglobulin. At concentrations of up to 100 ppm (equivalent to 100 g/mL) of the test material, the data in Table 4.5 shows the percent binding of perfluorobutane sulfonate in rat, human and monkey serum is typically greater than 98%. At perfluorobutane sulfonate concentration of 250 ppm and 500 ppm (equivalent to 250 g/mL and 500 g/mL) the percent binding of the test material in rat, human and monkey serum ranged from 85% - 94%. The slightly lower value of the percent of perfluorobutane sulfonate bound to rat, human and monkey serum at concentrations of the test material above 100 ppm compared to below 100 ppm is suggestive of a saturation of the binding above 100 ppm. Conclusion: High levels of binding of perfluorobutane sulfonate to human albumin (94% binding at 100% physiological concentrations of albumin) and an apparent saturated binding of the test material to albumin at concentrations of perflurobutane sulfonate above 100 ppm – 250 ppm in rat, human and monkey serum was observed in this study.