Note data not MI: Reduced sodium: 2 available for (individual and genders combined control: 4 (individual and in each group event), p=0.69 Transient ischemic attack: reduced sodium: 7 individuals reporting 8 events, control: 7 individuals reporting 8 events, p>0.99 (not divided into ethnicity) Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing Reporting all Funding source randomisation concealment follow-up study early outcome results where for benefit required TONE Unclear risk (no Unclear risk (no Participants: Unclear risk Yes (low risk) No (low Unclear risk National Heart, description of description of unclear risk risk) (Reported that Lung and Blood Appel et al. method of method of there was no Institute, National (2001) Providers: sequence concealment of significant Institute on high risk generation) allocation) change in Aging, National cholesterol but Centre for Outcome did not report Research assessors: specific results) Resources of the unclear risk National
Note data not available for genders combined in each group MI: Reduced sodium: 2 (individual and control: 4 (individual and event), p=0.69 Transient ischemic attack: reduced sodium: 7 individuals reporting 8 events, control: 7 individuals reporting 8 events, p>0.99 (not divided into ethnicity) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to follow-up Use of where required Ceasing study early for benefit Reporting all outcome results Funding source TONE Appel et al. (2001) Unclear risk (no description of method of sequence generation) Unclear risk (no description of method of concealment of allocation) Participants: unclear risk Providers: high risk Outcome assessors: unclear risk Unclear risk Yes (low risk) No (low risk) Unclear risk (Reported that there was no significant change in cholesterol but did not report specific results) National Heart, Lung and Blood Institute, National Institute on Aging, National Centre for Research Resources of the National