Beanlands et SR of level IV studies Searches were divided into 4 categories: Search period: Dobutamine stress CMR k = 11 al. () High risk of bias CAD and/or ischemia detection and Up to June 2005 CTCA diagnosis Canada (AMSTAR 2/11) Databases searched: 16-slice: k = 19 CAD prognostication Myocardial viability detection Medline, EMBASE, Cochrane library, and other evidence-based 64-slice: k = 4 Myocardial viability prognostication medicine Web sites, such as that of the Agency for Healthcare Research and Quality. Inclusion criteria: A systematic search of the literature, using validated British Medical Journal filters for diagnosis and prognosis, was used to identify the best evidence for use of CTCA and CMR. Exclusion criteria: None reported Bernhardt et Level IV N=34 patients with stable angina and Exclusion criteria: Adenosine SP-CMR al. () suspected or known CAD referred for ICA A case series with either Not reported Germany post-test or Mean age: 62 ± 11 years outcomes n=8/34 women (24%) Moderate risk of bias PROCAM score 42.7 ± 8.8 (IHE 6/12) CAD risk factors: hypertension 79% hypercholesterolaemia 53% smoker 47% diabetes 15% Bettencourt et Level IV N=113/176 consecutive patients referred Inclusion criteria: Adenosine SP-CMR + LGE al. () by general physicians to the hospital A case series with either Age >40 years, symptoms compatible with CAD and ≥2 risk factors outpatient cardiology clinic due to clinical Portugal post-test or and/or a positive/ inconclusive treadmill test suspicion of CAD with an intermediate or outcomes high PTP for CAD according to the Exclusion criteria: modified Diamond-Forrester score Low risk of bias Unstable clinical status; previous MI, CABG or PCI; valvular heart
Beanlands et al. () Canada SR of level IV studies High risk of bias (AMSTAR 2/11) Searches were divided into 4 categories: CAD and/or ischemia detection and diagnosis CAD prognostication Myocardial viability detection Myocardial viability prognostication Search period: Up to June 2005 Databases searched: Medline, EMBASE, Cochrane library, and other evidence-based medicine Web sites, such as that of the Agency for Healthcare Research and Quality. Inclusion criteria: A systematic search of the literature, using validated British Medical Journal filters for diagnosis and prognosis, was used to identify the best evidence for use of CTCA and CMR. Exclusion criteria: None reported Dobutamine stress CMR k = 11 CTCA 16-slice: k = 19 64-slice: k = 4 Bernhardt et al. () Germany Level IV A case series with either post-test or outcomes Moderate risk of bias (IHE 6/12) N=34 patients with stable angina and suspected or known CAD referred for ICA Mean age: 62 ± 11 years n=8/34 women (24%) PROCAM score 42.7 ± 8.8 CAD risk factors: hypertension 79% hypercholesterolaemia 53% smoker 47% diabetes 15% Exclusion criteria: Not reported Adenosine SP-CMR Bettencourt et al. () Portugal Level IV A case series with either post-test or outcomes Low risk of bias N=113/176 consecutive patients referred by general physicians to the hospital outpatient cardiology clinic due to clinical suspicion of CAD with an intermediate or high PTP for CAD according to the modified Diamond-Forrester score Inclusion criteria: Age >40 years, symptoms compatible with CAD and ≥2 risk factors and/or a positive/ inconclusive treadmill test Exclusion criteria: Unstable clinical status; previous MI, CABG or PCI; valvular heart Adenosine SP-CMR + LGE