Migraine Last updated: September 5, 2017 Galen's hemicrania low Latin hemigranea migranea French migraine → → → Migraine is 2nd most common primary headache disorder! Migraine is still underdiagnosed and undertreated! Exact pathophysiology unknown! Traditional vascular theory (already obsolete) intracranial vasoconstriction aura. → painful reactive extracranial vasodilation headache. → arguments against this theory: theory cannot explain features. prodromal theory cannot explain reason some antimigraine drugs have no effect on cerebral vasculature. not been substantiated by cerebral flow (CBF) studies.
Migraine Last updated: September 5, 2017 Galen's hemicrania → low Latin hemigranea → migranea → French migraine Migraine is 2nd most common primary headache disorder! Migraine is still underdiagnosed and undertreated! Exact pathophysiology unknown! Traditional vascular theory (already obsolete) intracranial vasoconstriction → aura. painful reactive extracranial vasodilation → headache. arguments against this theory: theory cannot explain prodromal features. theory cannot explain reason some antimigraine drugs have no effect on cerebral vasculature. not been substantiated by cerebral flow (CBF) studies.