bodyweight gain. During week 2, one low-dose female showed bodyweight loss. Deceased animals or those euthanased showed lung Morphological findings: abnormalities including dark or abnormally reddened appearance, pale patches, enlargement and an isolated incidence of haemorrhage. The deceased male in the dose group also showed an abnormally dark liver with an accentuated lobular pattern. At necropsy at the end of the study, lungs of the surviving high-dose male showed several raised areas and the lungs of two low-dose females showed dark foci. Rapid deaths, severe respiratory changes and abnormal Comment: colouration and enlargement of lungs indicate the lung as a target organ and that the test material exerted an irritant effect in the respiratory tract. All animals: 3.07mg/L (3070mg/m3) LC50: Males: 2.83mg/L (2830mg/m3) Females: 3.22mg/L (3220mg/m3) The notified chemical was of low to moderate acute Result: inhalational toxicity in rats. 9.1.4 Skin Irritation (Kaufmann, 1997) Rabbit, New Zealand White Species/strain: 3, sex not specified Number/sex of animals: 4 days Observation period: 0.5mL of neat test substance applied to shaved, intact skin Method of administration: and covered with a semi-occlusive dressing fixed with elastic tape. OECD TG 404 Test method: Draize scores: Time after treatment Animal # 30-60 min 1 day 2 days 3 days 4 days Erythema 1 0a 0 0 0 0 2 0 1 1 0 0
bodyweight gain. During week 2, one low-dose female showed bodyweight loss. Morphological findings: Deceased animals or those euthanased showed lung abnormalities including dark or abnormally reddened appearance, pale patches, enlargement and an isolated incidence of haemorrhage. The deceased male in the group also showed an abnormally dark liver with an accentuated lobular pattern. At necropsy at the end of the study, lungs of the surviving high-dose male showed several raised areas and the lungs of two low-dose females showed dark foci. Comment: Rapid deaths, severe respiratory changes and abnormal colouration and enlargement of lungs indicate the lung as a target organ and that the test material exerted an irritant effect in the respiratory tract. LC50: All animals: 3.07mg/L (3070mg/m3) Males: 2.83mg/L (2830mg/m3) Females: 3.22mg/L (3220mg/m3) Result: The notified chemical was of low to moderate acute inhalational toxicity in rats. 9.1.4 Skin Irritation (Kaufmann, 1997) Species/strain: Rabbit, New Zealand White Number/sex of animals: 3, sex not specified Observation period: 4 days Method of administration: 0.5mL of neat test substance applied to shaved, intact skin and covered with a semi-occlusive dressing fixed with elastic tape. Test method: OECD TG 404 Draize scores: Time after treatment Animal # 30-60 min 1 day 2 days 3 days 4 days Erythema 1 0a 0 0 0 0 2 0 1 1 0 0 dose