Test Species Outcome Reference oral toxicity rat LD50 > 2000mg/kg Arcelin (1996b) acute dermal toxicity rat LD50 > 2000mg/kg Arcelin skin irritation rabbit Non-irritant (1997b) eye irritation rabbit Slight irritant Braun (1997a) skin sensitisation guinea pig Not sensitising Arcelin (1997) 9.1.1 Oral Toxicity (Arcelin, 1996b) Rats, Hanlbm:Wist Species/strain: 5 males, 5 females Number/sex of animals: 14 days Observation period: Gavage Method of administration: OECD TG 401 Test method: None Mortality: No clinical of toxicity were observed during the Clinical observations: observation period and the body weights of the animals were within the ranges of physiological variability. No macroscopic organ abnormalities were observed at Morphological findings: necroscopy. >2000 mg/kg LD50: The notified chemical was of very low acute oral toxicity in Result: rats. 9.1.2 Dermal Toxicity (Arcelin, 1996a) Rats, Hanlbm:Wist Species/strain: 5 males, 5 females Number/sex of animals: 14 days Observation period: The notified chemical was applied evenly on intact skin at Method of administration: 2000 mg/kg and covered with a semi-occlusive dressing. OECD TG 402 Test method:
Test Species Outcome Reference oral toxicity rat LD50 > 2000mg/kg Arcelin (1996b) acute dermal toxicity rat LD50 > 2000mg/kg Arcelin skin irritation rabbit Non-irritant (1997b) eye irritation rabbit Slight irritant Braun (1997a) skin sensitisation guinea pig Not sensitising Arcelin (1997) 9.1.1 Oral Toxicity (Arcelin, 1996b) Species/strain: Rats, Hanlbm:Wist Number/sex of animals: 5 males, 5 females Observation period: 14 days Method of administration: Gavage Test method: OECD TG 401 Mortality: None Clinical observations: No clinical of toxicity were observed during the observation period and the body weights of the animals were within the ranges of physiological variability. Morphological findings: No macroscopic organ abnormalities were observed at necroscopy. LD50: >2000 mg/kg Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Arcelin, 1996a) Species/strain: Rats, Hanlbm:Wist Number/sex of animals: 5 males, 5 females Observation period: 14 days Method of administration: The notified chemical was applied evenly on intact skin at 2000 mg/kg and covered with a semi-occlusive dressing. Test method: OECD TG 402