one of the two was reported as (SEM: 0.9, CI: cross-over arms: 20.2 + 3.6 mEq/8hr -1.84) 1. Reduced salt DBP: diet with salt supplementation (SEM: 0.8, CI: (providing 96 mEq -0.73) sodium/day) 2. Reduced salt diet with placebo Key features for bias assessment of randomised trials Citation Method of Allocation Blinding Loss to Use of Ceasing study Reporting Funding source randomisation concealment early for benefit all where outcome required results Mascioli Low risk Unclear risk (block Participants: 4% loss to No (unclear risk) No (low risk) Yes (low National et al. randomisation) randomisation but low risk follow-up (low risk) Institutes of (1991) not clear who was risk) Health (low risk) Providers: low responsible etc.) risk Outcome assessors: unclear risk
one of the two cross-over arms: 1. Reduced salt diet with salt supplementation (providing 96 mEq sodium/day) 2. Reduced salt diet with placebo was reported as 20.2 + 3.6 mEq/8hr (SEM: 0.9, CI: -1.84) DBP: (SEM: 0.8, CI: -0.73) Key features for bias assessment of randomised trials Citation Method of randomisation Allocation concealment Blinding Loss to Use of where required Ceasing study early for benefit Reporting all outcome results Funding source Mascioli et al. (1991) Low risk randomisation) Unclear risk (block randomisation but not clear who was responsible etc.) Participants: low risk Providers: low risk Outcome assessors: unclear risk 4% loss to follow-up (low risk) No (unclear risk) No (low risk) Yes (low risk) National Institutes of Health (low risk)