Cross-sectional (cohort type accuracy False 25 17 4 study) positives (8–59) (6–39) (1–10) - ICA cut-off 70% DS - - - - - 45% - True N=466 patients Not serious Not serious Not serious Not serious None 63 189 357 High k=5 studies positives (54–74) (162–221) (306–417) ⊕⊕⊕⊕ Cross-sectional (cohort type accuracy False study) 87 261 493 negatives (76–96) (229–288) (433–544) True N=563 patients Not serious Serious Not serious Not serious None 808 523 143 Moderate negatives k=5 studies (714–833) (462–539) (126–147) ⊕⊕⊕⨀ (substantial Cross-sectional heterogeneity; (cohort type accuracy I2 = study) False 42 27 7 positives (17–136) (11–88) (3–24) - All studies - - - - - 45% - True N=519 patients Not serious Not serious Not serious Not serious None 61 185 349 High positives k=7 studies (53–69) (158–207) (298–391) ⊕⊕⊕⊕ Cross-sectional (cohort type accuracy False study) 89 265 501 negatives (81–97) (243–292) (459–552) True N=624 patients Not serious Serious Not serious Not serious None 816 528 144 Moderate negatives k=7 studies (774–842) (501–545) (137–149) ⊕⊕⊕⨀ (substantial False Cross-sectional heterogeneity; positives (cohort type accuracy I2 = study) 34 22 6 (8–76) (5–49) (1–13)
False positives Cross-sectional (cohort type accuracy study) 25 17 4 (8–59) (6–39) (1–10) - ICA cut-off 70% DS - - - - - 45% - True positives False negatives N=466 patients k=5 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Not serious Not serious None 63 189 357 (54–74) (162–221) (306–417) 87 261 493 (76–96) (229–288) (433–544) High ⊕⊕⊕⊕ True negatives False positives N=563 patients k=5 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 808 523 143 (714–833) (462–539) (126–147) 42 27 7 (17–136) (11–88) (3–24) Moderate ⊕⊕⊕⨀ - All studies - - - - - 45% - True positives False negatives N=519 patients k=7 studies Cross-sectional (cohort type accuracy study) Not serious Not serious Not serious Not serious None 61 185 349 (53–69) (158–207) (298–391) 89 265 501 (81–97) (243–292) (459–552) High ⊕⊕⊕⊕ True negatives False positives N=624 patients k=7 studies Cross-sectional (cohort type accuracy study) Not serious Serious (substantial heterogeneity; I2 = Not serious Not serious None 816 528 144 (774–842) (501–545) (137–149) 34 22 6 (8–76) (5–49) (1–13) Moderate ⊕⊕⊕⨀