Section 11. Toxicological information Diphenylmethane 4,4'- Irritating to skin. 4,4'-MDI No additional information. HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Homopolymer of methylenediphenyl Irritating to skin. diisocyanate Slightly irritating to the skin. Eyes Based on the human occupational exposure data, this Diphenylmethane 4,4'- substance is considered as irritating to eyes. No additional information. 4,4'-MDI HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Irritating to eyes. Homopolymer of methylenediphenyl diisocyanate Slightly irritating to the eyes. No additional information. Respiratory Diphenylmethane 4,4'- No additional information. 4,4'-MDI HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Homopolymer of No additional information. methylenediphenyl diisocyanate No additional information. Sensitization Product/ingredient name Test Route of exposure Species Result Diphenylmethane 4,4'- OECD 429 Skin skin Mouse Sensitizing diisocyanate Sensitization: Local Lymph Node Assay OECD 406 Skin skin Guinea pig Not sensitizing Sensitization Respiratory Guinea pig Sensitizing No official guidelines skin Guinea pig Sensitizing Homopolymer of OECD 406 Skin methylenediphenyl Sensitization diisocyanate Respiratory Guinea pig Sensitizing No official guidelines skin Human Not sensitizing No official guidelines Respiratory Guinea pig Sensitizing 4,4'-Methylenediphenyl No official diisocyanate, oligomeric guidelines reaction products with butane- 1,3-diol, 2,4'-diisocyanatod iphenylmethane, 1,1'-methylenebis (4-isocyanatobenzene) homopolymer, [ (methylethylene)bis(oxy)] 8/5/2014. Not available. 9/20
Section 11. Toxicological information Diphenylmethane 4,4'-MDI HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Homopolymer of methylenediphenyl diisocyanate Irritating to skin. No additional information. Irritating to skin. Slightly irritating to the skin. Eyes Respiratory Sensitization Diphenylmethane 4,4'-MDI HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Homopolymer of methylenediphenyl diisocyanate Diphenylmethane 4,4'-MDI HOMOPOLYMER/1 ,3-BD/ PG/TPG (NCO-ENDED) Homopolymer of methylenediphenyl diisocyanate Based on the human occupational exposure data, this substance is considered as irritating to eyes. No additional information. Irritating to eyes. Slightly irritating to the eyes. No additional information. No additional information. No additional information. No additional information. Product/ingredient name Test Route of exposure Species Result Diphenylmethane 4,4'- diisocyanate OECD 429 Skin Sensitization: skin Mouse Sensitizing Local Lymph Node Assay OECD 406 Skin skin Guinea pig Not sensitizing Sensitization No official guidelines Respiratory Guinea pig Sensitizing Homopolymer of methylenediphenyl diisocyanate OECD 406 Skin Sensitization skin Guinea pig Sensitizing No official guidelines Respiratory Guinea pig Sensitizing No official guidelines skin Human Not sensitizing 4,4'-Methylenediphenyl diisocyanate, oligomeric reaction products with butane- No official guidelines Respiratory Guinea pig Sensitizing 1,3-diol, 2,4'-diisocyanatod iphenylmethane, 1,1'-methylenebis (4-isocyanatobenzene) homopolymer, [ (methylethylene)bis(oxy)] 8/5/2014. Not available. 9/20 4,4'- 4,4'- 4,4'-