gait were also noted in males treated with 100 mg/kg; loss of righting reflex was commonly noted in males treated with 500 mg/kg; males treated with 100 mg/kg recovered one or two days after dosing; females treated with 100 mg/kg and males treated with 224 mg/kg appeared normal throughout the study; all surviving animals showed expected bodyweight gain during the study all animals treated with 500 mg/kg were dead 2 - Mortality: 4 hours after dosing in males treated with 500 mg/kg that died during the Morphological findings: study: haemorrhagic lungs, dark liver and dark kidneys according to OECD TG 401 (Organisation for Test method: Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992) 334 mg/kg in LD50: the notified chemical exhibited moderate acute Result: oral toxicity in rats Toner containing NT-6 (#1015) (Allen, 1996a) rat/Sprague Dawley Species/strain: 5 males/5 females Number/sex of animals: 14 days Observation period: gavage; vehicle: arachis oil Method of administration: none Clinical observations: none Mortality: none Morphological findings: limit test, similar to OECD TG 401 (Organisation Test method: for Economic Co-operation and Development, 1995-1996)
gait were also noted in males treated with 100 mg/kg; loss of righting reflex was commonly noted in males treated with 500 mg/kg; males treated with 100 mg/kg recovered one or two days after dosing; females treated with 100 mg/kg and males treated with 224 mg/kg appeared normal throughout the study; all surviving animals showed expected bodyweight gain during the study Mortality: all animals treated with 500 mg/kg were dead 2 - 4 hours after dosing Morphological findings: in males treated with 500 mg/kg that died during the study: haemorrhagic lungs, dark liver and dark kidneys Test method: according to OECD TG 401 (Organisation for Economic Co-operation and Development, 1995- 1996) and Commission Directive 92/69/EEC (European Economic Community, 1992) LD50: 334 mg/kg in Result: the notified chemical exhibited moderate acute oral toxicity in rats Toner containing NT-6 (#1015) (Allen, 1996a) Species/strain: rat/Sprague Dawley Number/sex of animals: 5 males/5 females Observation period: 14 days Method of administration: gavage; vehicle: arachis oil Clinical observations: none Mortality: none Morphological findings: none Test method: limit test, similar to OECD TG 401 (Organisation for Economic Co-operation and Development, 1995-1996)