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References Chen, D., Dou, P. (2010). The Ubiquitin-Proteasome System as a Prospective Molecular Target for Cancer Treatment and Prevention. Current Protein & Peptide Science, 11(6), 459 – 470. Forristal, C., Henley, SA., MacDonald, JI., Bush, JR., Ort, C., Passos, DT., Talluri, S., et al. (2014). Loss of Mammalian DREAM Complex Deregulates Chondrocyte Proliferation. Molecular and Cellular Biology, 34(12), 2221 – 2234. Guiley, KZ., Liban, TJ., Felthousen, JG., Ramanan, P., Litovchick, L., and Rubin, SM. (2015). Structural mechanisms of DREAM complex assembly and regulation. Genes & Dev, 29(9), 961 – 974. Huber, LA. (2003). Is proteomics heading in the wrong direction?. Nature Reviews Molecular Cell Biology, 4, 74 – 80. Iconomou, M., Saunders, DN., (2016). Systematic approaches to identify E3 ligase substrates. Biochemical Journal, 473, 4083 – 4101. Iles, LR., Bartholomeusz, GA. (2016). Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi Screens. Methods in Molecular Biology, 1470, 121- 135.