MacGregor Unclear risk(no Unclear risk (not Participants: 0% loss to Not required No (low risk) Unclear risk Not stated et al. description of described) low risk follow-up (low (low risk) (Insufficient (unclear risk) (1987) method of risk) data in Providers: low sequence to calculate risk generation) changes in MAP for Outcome group) assessors: unclear risk Summary Citation Study Population Intervention Outcomes Sample Intervention Compliance to Results & design level measured size duration sodium target location of relevant to (urinary data) research question II Adults (aged 42 Participants were Blood pressure 20 1 month 200mmol Mean results at et al. - 72), with instructed to reduce (supine and sodium/day arm: end of low (n = 15 pts. (1989), hypertension dietary sodium to 30 standing), mean 190 (SEM: 11, CI: sodium diet – also followed UK (DBP> 90 110 50 mmol/day for two arterial pressure 168, 212) mmHg and – up for 1 year study mmHg) weeks. Participants (results not intermediate [] study) 100mmol were then randomised reported in sodium diet: sodium/day arm: to start one of three paper) 108 (SEM: 10, CI: SBP: cross-over arms: 88, 129) mmHg Low: 147mmHg 1. Restricted sodium (SEM: 4) diet plus placebo
MacGregor et al. (1987) Unclear risk(no description of method of sequence generation) Unclear risk (not described) Participants: low risk Providers: low risk Outcome assessors: unclear risk 0% loss to follow-up (low risk) Not required (low risk) No (low risk) Unclear risk (Insufficient data in to calculate changes in MAP for group) Not stated (unclear risk) Summary Citation & location Study design level of Population Intervention Outcomes measured relevant to research question Sample size Intervention duration Compliance to sodium target (urinary data) Results et al. (1989), UK [] study II Adults (aged 42 - 72), with hypertension (DBP> 90 – 110 mmHg) Participants were instructed to reduce dietary sodium to 30 – 50 mmol/day for two weeks. Participants were then randomised to start one of three cross-over arms: 1. Restricted sodium diet plus placebo Blood pressure (supine and standing), mean arterial pressure (results not reported in paper) 20 1 month (n = 15 pts. also followed up for 1 year study) 200mmol sodium/day arm: 190 (SEM: 11, CI: 168, 212) mmHg 100mmol sodium/day arm: 108 (SEM: 10, CI: 88, 129) mmHg Mean results at end of low sodium diet and intermediate sodium diet: SBP: Low: 147mmHg (SEM: 4)