> 2 000 mg.kg-1 LD50: Foraperle 321 was of low acute toxicity when Result: orally administered to rats in a limit test Skin Irritation [Besson C, 1993 #225] rabbit/New Zealand White Species/strain: 3/female Number/sex of animals: 72 hours Observation period: single topical doses of 0.5 mL test substance to the Method of administration: flank; test site was covered by semi- occlusive wrap for 4 hours Draize scores [Draize, 1959 all Draize scores at all time points were zero #4]: according to OECD guidelines [Organisation for Test method: Economic Co-operation and Development, 1995- 1996 #15] Foraperle 321 was not irritating to rabbit skin Result: Eye Irritation [Besson C, 1993 #226] rabbit/New Zealand White Species/strain: 3/female (the first of the three was used in a pre- Number/sex of animals: study) 8 days Observation period: 0.1 mL of the test substance instilled into the Method of administration: conjunctival sac of the left eye; the right eye served as a control
LD50: > 2 000 mg.kg-1 Result: Foraperle 321 was of low acute toxicity when orally administered to rats in a limit test Skin Irritation [Besson C, 1993 #225] Species/strain: rabbit/New Zealand White Number/sex of animals: 3/female Observation period: 72 hours Method of administration: single topical doses of 0.5 mL test substance to the flank; test site was covered by semi- occlusive wrap for 4 hours Draize scores [Draize, 1959 #4]: all Draize scores at all time points were zero Test method: according to OECD guidelines [Organisation for Economic Co-operation and Development, 1995- 1996 #15] Result: Foraperle 321 was not irritating to rabbit skin Eye Irritation [Besson C, 1993 #226] Species/strain: rabbit/New Zealand White Number/sex of animals: 3/female (the first of the three was used in a pre- study) Observation period: 8 days Method of administration: 0.1 mL of the test substance instilled into the conjunctival sac of the left eye; the right eye served as a control