TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. 3 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure 5 6.1.1 Occupational exposure 5 6.1.2 Public exposure 6 6.2 Human health effects assessment 6 6.3 Human health risk characterisation 7 6.3.1 Occupational health and safety 7 6.3.2 Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1 Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2 Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3 Environmental risk assessment 11 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 11 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity oral 16 – B.2. Acute toxicity dermal 16 – B.3. Irritation skin 17 – B.4. Irritation eye 17 – B.5. Skin sensitisation mouse local lymph node assay (LLNA) 18 – B.6. Repeat dose toxicity 19 B.7. Genotoxicity bacteria 20 – B.8. Genotoxicity in vitro 21 – Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.2.1. Acute toxicity to aquatic invertebrates 23 C.2.2. Algal growth inhibition test 24 C.2.3. Inhibition of microbial activity 25 Bibliography 26
TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. 3 4. PHYSICAL AND CHEMICAL PROPERTIES 4 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure 5 6.1.1 Occupational exposure 5 6.1.2 Public exposure 6 6.2 Human health effects assessment 6 6.3 Human health risk characterisation 7 6.3.1 Occupational health and safety 7 6.3.2 Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1 Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2 Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3 Environmental risk assessment 11 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 11 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity – oral 16 B.2. Acute toxicity – dermal 16 B.3. Irritation – skin 17 B.4. Irritation – eye 17 B.5. Skin sensitisation – mouse local lymph node assay (LLNA) 18 B.6. Repeat dose toxicity 19 B.7. Genotoxicity – bacteria 20 B.8. Genotoxicity – in vitro 21 Appendix C: Environmental Fate and Ecotoxicological Investigations 23 C.2.1. Acute toxicity to aquatic invertebrates 23 C.2.2. Algal growth inhibition test 24 C.2.3. Inhibition of microbial activity 25 Bibliography 26