Analgesic and Anti-inflammatory Activities of Dichrostachys Glomerata (Forssk.) Hutch. Fruits Methanolic Extract in Rats Abstract The present study has been undertaken to assess the analgesic and the anti-inflammatory properties of methanolic extract fruit. Pain was induced in mice by Dichrostachys glomerata the intraperitoneal administration of 1 % acetic acid, and formalin . Carrageenan and histamin (1%) were used to induce inflammation in rat paws. At the doses of 25 and 50 mg/kg, D. glomerata significantly inhibited pain induced by acetic acid with a percentage inhibition of 80.0 and 76.0 %, respectively. The neurogenic pain induced by formalin was significantly inhibited by the plant extract at the doses of 25 and 50 mg/kg (56.14 and 61.46% inhibition respectively) while the inflammatory phase was significantly inhibited at all the doses tested. The extract (25 mg/kg) significantly reduced oedema induced by carrageenan with 79.85 % inhibition at after 30 minutes while the oedema induced by the serotonin was also significantly inhibited the plant extract Key words: rats; inflammation; central and peripheral Key words: Dichrostachys glomerata; analgesic
Analgesic and Anti-inflammatory Activities of Dichrostachys Glomerata (Forssk.) Hutch. Fruits Methanolic Extract in Rats Abstract The present study has been undertaken to assess the analgesic and the anti-inflammatory properties of methanolic extract Dichrostachys glomerata fruit. Pain was induced in mice by the intraperitoneal administration of 1 % acetic acid, and formalin . Carrageenan and histamin (1%) were used to induce inflammation in rat paws. At the doses of 25 and 50 mg/kg, D. glomerata significantly inhibited pain induced by acetic acid with a percentage inhibition of 80.0 and 76.0 %, respectively. The neurogenic pain induced by formalin was significantly inhibited by the plant extract at the doses of 25 and 50 mg/kg (56.14 and 61.46% inhibition respectively) while the inflammatory phase was significantly inhibited at all the doses tested. The extract (25 mg/kg) significantly reduced oedema induced by carrageenan with 79.85 % inhibition at after 30 minutes while the oedema induced by the serotonin was also significantly inhibited the plant extract Key words: Key words: Dichrostachys glomerata; rats; inflammation; central and peripheral analgesic