Table 257 Total folate and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Cases/ Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analyses (years) Age, sex, year of questionnaire return, regular aspirin use, BMI, endoscopy Mid-points of status, family exposure NHS-HPFS, history of categories. Prospective colorectal The Pooling Nishihara, 2014 Cohort, Medical records cancer, 993/ Incidence, vs Project Kim, ≥400 ≤200 COL41036 Age: 30-75 and death 1.00 (0.76-1.32) multivitamin FFQ colorectal cancer mcg/day 2010 was used USA M/W, registries use, pack for dose nurses & health smoked, response professionals physical analysis on activity, red cancer meat, vitamin B12, vitamin B6, calcium, methionine, total caloric intake Distribution of person-years by Health Age, BMI, exposure Initiative - colonoscopy, category Observational Zschäbitz, 2013 808/ Self report ethnicity, The Pooling study, Incidence, COL40934 88 045 verified by FFQ vs 0-242 0.90 (0.74-1.10) hormone use, Project Kim, ≥939 Prospective colorectal cancer USA 11 years medical record physical 2010 was used Cohort, activity, for dose W, smoking response Postmenopausal analysis on colon cancer
Table 257 Total folate and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analyses Nishihara, 2014 COL41036 USA NHS-HPFS, Prospective Cohort, Age: 30-75 M/W, nurses & health professionals 993/ Medical records and death registries FFQ Incidence, colorectal cancer ≥400 vs ≤200 mcg/day 1.00 (0.76-1.32) Age, sex, year of questionnaire return, regular aspirin use, BMI, endoscopy status, family history of colorectal cancer, multivitamin use, pack smoked, physical activity, red meat, vitamin B12, vitamin B6, calcium, methionine, total caloric intake Mid-points of exposure categories. The Pooling Project Kim, 2010 was used for dose response on cancer Zschäbitz, 2013 COL40934 USA Health Initiative - Observational study, Prospective Cohort, W, Postmenopausal 808/ 88 045 11 years Self report verified by medical record FFQ Incidence, colorectal cancer ≥939 vs 0-242 0.90 (0.74-1.10) Age, BMI, colonoscopy, ethnicity, hormone use, physical activity, smoking Distribution of person-years by exposure category The Pooling Project Kim, 2010 was used for dose response on colon cancer analysis analysis