Grade 3 Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated hrs ≥24 Grade 4 Life-threatening consequences Grade 5 Death ADL: activities of daily life, e.g.: for exemple, IV: intra veinous, TPN: total parenteral nutrition. Additional Table 2: Rectal dosimetric parameters according to morbidity grade Proctitis Bleeding Stenosis Fistula All Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Grade 0 65.9±9.0 65.7±8.9 66.2±9.1 66.1±9.0 65.5±8.2 66.2±9.1 66.0±9.0 66.0±9.0 66.1±9.0 66.1±9.0 0.24 Grade 1 66.8±8.8 68.3±9.5 68.6±5.5 -- 66.9±8.7 0.019 0.0002 (Gy) 0.018 0.005 0.001 0.004 0.194 0.003 0.0001 Grade 2 71.0±11.4 71.6±12.2 70.9±9.4 75.6±15.6 70.6±11.5 70.9±9.5 DICRU 79.2±13 70.8±11.3 70.9±11.2 79.2±13.4 Grade 3 68.7±12.0 68.5±7.8 -- 77.5±7.0 70.6±8.6 .4 Grade 4 -- -- -- 98.4 --* 98.4 --*
Grade 3 Symptomatic and severely altered GI function (e.g., altered dietary habits, diarrhea, or GI fluid loss); IV fluids, tube feedings, or TPN indicated ≥24 hrs Grade 4 Life-threatening consequences Grade 5 Death ADL: activities of daily life, e.g.: for exemple, IV: intra veinous, TPN: total parenteral nutrition. Additional Table 2: Rectal dosimetric parameters according to morbidity grade Proctitis Bleeding Stenosis Fistula All Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p Mean±Sd p DICRU (Gy) Grade 0 65.9±9.0 0.018 66.0±9.0 0.005 65.7±8.9 0.001 66.0±9.0 0.004 66.2±9.1 0.24 66.2±9.1 0.194 66.1±9.0 0.019 66.1±9.0 0.003 65.5±8.2 0.0002 66.1±9.0 0.0001 Grade 1 66.8±8.8 68.3±9.5 68.6±5.5 -- 66.9±8.7 Grade 2 71.0±11.4 70.8±11.3 71.6±12.2 70.9±11.2 70.9±9.4 70.9±9.5 75.6±15.6 79.2±13.4 70.6±11.5 79.2±13 .4 Grade 3 68.7±12.0 68.5±7.8 -- 77.5±7.0 70.6±8.6 Grade 4 -- -- -- 98.4 --* 98.4 --*