Table 67 Processed meat and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Cases/ Author, Year, Missing data Study name, size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country analysis (years) vs ≥60 ≤15 674/ 1.59 (1.19-2.12) Incidence, g/day 84 538 colorectal cancer Only included in 11.1 per 50 g/day 1.21 (1.00-1.47) NOWAC, Age, alcohol, subgroup Prospective BMI, calcium, analysis. vs Parr, 2013 ≥60 ≤15 1.54 (1.08-2.19) Incidence, colon Cohort, energy, Component of g/day COL40955 459/ Cancer registry FFQ Age: 41-70 cancer physical the EPIC study. Norway years, per 50 g/day 1.22 (0.97-1.54) activity, Superseded by W smoking Norat, 2005 vs ≥60 ≤15 COL01698 1.71 (1.02-2.85) Incidence, rectal g/day 215/ cancer per 50 g/day 1.18 (0.84-1.67) Age, sex, age at cohort entry In Distribution of log model, person-years by alcohol exposure consumption, category. BMI, calcium, MEC, of dietary fibre, Ollberding, Prospective exposure 3 404/ Cancer registry energy intake, 2012 Cohort, Incidence, 17.98 vs 1.7 categories. 165 717 and national trial FFQ 1.06 (0.94-1.19) ethnicity, family COL40941 Age: 45-75 colorectal cancer g/1000 kcal/day Intakes in 8.1 years Index history of Hawaii, USA years, g/1000kcal/day colorectal M/W converted to cancer, folate, g/day using history of average energy diabetes, history intake per each of polyp quantile diagnosis, HRT use, non-steroid
Table 67 Processed meat and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Cases/ size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for analysis Parr, 2013 COL40955 Norway NOWAC, Prospective Cohort, Age: 41-70 years, W 674/ 84 538 11.1 Cancer registry FFQ Incidence, colorectal cancer ≥60 vs ≤15 g/day 1.59 (1.19-2.12) Age, alcohol, BMI, calcium, energy, physical activity, smoking Only included in subgroup analysis. Component of the EPIC study. Superseded by Norat, 2005 COL01698 per 50 g/day 1.21 (1.00-1.47) 459/ Incidence, colon cancer ≥60 vs ≤15 g/day 1.54 (1.08-2.19) per 50 g/day 1.22 (0.97-1.54) 215/ Incidence, rectal cancer ≥60 vs ≤15 g/day 1.71 (1.02-2.85) per 50 g/day 1.18 (0.84-1.67) Ollberding, 2012 COL40941 Hawaii, USA MEC, Prospective Cohort, Age: 45-75 years, M/W 3 404/ 165 717 8.1 years Cancer registry and national Index FFQ Incidence, colorectal cancer 17.98 vs 1.7 g/1000 kcal/day 1.06 (0.94-1.19) Age, sex, age at cohort entry In log model, alcohol consumption, BMI, calcium, dietary fibre, energy intake, ethnicity, family history of colorectal cancer, folate, history of diabetes, history of polyp diagnosis, HRT use, non-steroid Distribution of person-years by exposure category. of exposure categories. Intakes in g/1000kcal/day converted to g/day using average energy intake per each quantile analysis trial