Tables Table 1: Composition and extrusion parameters of co-extruded formulations. Table 2: Mean adhesion force in N (±S.D.) between core and coat in function of drug load (0%, 30%, 50%) and extrusion temperature (70, 95, 120 °C). Table 3: Mean pharmacokinetic parameters (±S.D.) after oral administration of 100 mg diclofenac sodium to dogs as F2, F3, F4 or as reference formulation (Motifene®). Table 1: Composition and extrusion parameters of co-extruded formulations. DS concentration Textr Feed rate Screw speed Die dimensions DS ratio (%) (°C) (g/h) (rpm) (mm) core:coat core coat core coat core coat core coat F1 60 25 140 200 200 60 60 3 0.5 70:30 F2 50 22.5 95 150 150 60 60 3 0.5 70:30 F3 50 50 95 200 150 60 60 3 0.5 57:43 F4 50 50 120 200 600 80 80 2 1 25:75 F5 0 0 70 200 150 60 60 3 0.5 - F6 0 0 95 200 150 60 60 3 0.5 - F7 0 0 120 200 150 60 60 3 0.5 - F8 30 30 70 200 150 60 60 3 0.5 57:43 F9 30 30 95 200 150 60 60 3 0.5 57:43 F10 30 30 120 200 150 60 60 3 0.5 57:43 F11 50 50 95 200 150 60 60 3 0.5 57:43 F12 50 50 120 200 150 60 60 3 0.5 57:43
Tables Table 1: Composition and extrusion parameters of co-extruded formulations. Table 2: Mean adhesion force in N (±S.D.) between core and coat in function of drug load (0%, 30%, 50%) and extrusion temperature (70, 95, 120 °C). Table 3: Mean pharmacokinetic parameters (±S.D.) after oral administration of 100 mg diclofenac sodium to dogs as F2, F3, F4 or as reference formulation (Motifene®). Table 1: Composition and extrusion parameters of co-extruded formulations. DS concentration (%) Textr (°C) Feed rate (g/h) Screw speed (rpm) Die dimensions (mm) DS ratio core:coat core coat core coat core coat core coat F1 60 25 140 200 200 60 60 3 0.5 70:30 F2 50 22.5 95 150 150 60 60 3 0.5 70:30 F3 50 50 95 200 150 60 60 3 0.5 57:43 F4 50 50 120 200 600 80 80 2 1 25:75 F5 0 0 70 200 150 60 60 3 0.5 - F6 0 0 95 200 150 60 60 3 0.5 - F7 0 0 120 200 150 60 60 3 0.5 - F8 30 30 70 200 150 60 60 3 0.5 57:43 F9 30 30 95 200 150 60 60 3 0.5 57:43 F10 30 30 120 200 150 60 60 3 0.5 57:43 F11 50 50 95 200 150 60 60 3 0.5 57:43 F12 50 50 120 200 150 60 60 3 0.5 57:43