AUC Area under the plasma/serum/PBMC concentration versus time curve AUCtau Area under the plasma/serum/PBMC concentration versus time curve over the dosing interval BA Bioavailability BCRP Breast cancer resistance protein BCS Biopharmaceutics Classification System BID daily BMI Body mass index BOC Boceprevir BSEP Bile salt export pump CatA Cathepsin A CES1 Carboxyl esterase 1 CHC Chronic Hepatitis C CI Confidence interval CLDQ-HCV Chronic Liver Disease Questionnaire HCV Version CL/F Apparent oral clearance Cmax Maximum observed plasma/serum/PBMC concentration of drug CNS Central nervous system COBI Cobicistat CPT classification CRCL Creatinine clearance CsA Cyclosporine (cyclosporin A; ciclosporin) Ctau Observed drug concentration at the end of the dosing interval Conditional weighted residual CYP Cytochrome P450 enzyme(s)
AUC Area under the plasma/serum/PBMC concentration versus time curve AUCtau Area under the plasma/serum/PBMC concentration versus time curve over the dosing interval BA Bioavailability BCRP Breast cancer resistance protein BCS Biopharmaceutics Classification System BID daily BMI Body mass index BOC Boceprevir BSEP Bile salt export pump CatA Cathepsin A CES1 Carboxyl esterase 1 CHC Chronic Hepatitis C CI Confidence interval CLDQ-HCV Chronic Liver Disease Questionnaire HCV Version CL/F Apparent oral clearance Cmax Maximum observed plasma/serum/PBMC concentration of drug CNS Central nervous system COBI Cobicistat CPT classification CRCL Creatinine clearance CsA Cyclosporine (cyclosporin A; ciclosporin) Ctau Observed drug concentration at the end of the dosing interval Conditional weighted residual CYP Cytochrome P450 enzyme(s)