Judgement Problem No Probably no Probably yes Yes Varies Don't know Desirable Effects Trivial Small Moderate Large Varies Don't know Undesirable Effects Large Moderate Small Trivial Varies Don't know Certainty of Very low Low Moderate High No included studies evidence Possibly Important Probably no important No important important No undesirable Values uncertainty or uncertainty or uncertainty or uncertainty or outcomes variability variability variability variability Does not favor either the Favors the Probably favors Probably favors Favors the Balance of effects intervention or the Varies Don't know comparison the comparison the intervention intervention comparison Negligible costs and Resources required Large costs Moderate costs Moderate savings Large savings Varies Don't know savings Certainty of evidence of Very low Low Moderate High No included studies required resources Does not favor either the Favors the Probably favors Probably favors Favors the Cost effectiveness intervention or the Varies No included studies comparison the comparison the intervention intervention comparison Probably Probably Equity Reduced Probably no impact Increased Varies Don't know reduced increased Acceptability No Probably no Probably yes Yes Varies Don't know Feasibility No Probably no Probably yes Yes Varies Don't know Conclusions Should an alpha-2 agonist (e.g., dexmedetomidine) vs. propofol be used in critially ill ventilated adults (both intubated and
Judgement Problem No Probably no Probably yes Yes Varies Don't know Desirable Effects Trivial Small Moderate Large Varies Don't know Undesirable Effects Large Moderate Small Trivial Varies Don't know Certainty of evidence Very low Low Moderate High No included studies Values Important uncertainty or variability Possibly important uncertainty or variability Probably no important uncertainty or variability No important uncertainty or variability No undesirable outcomes Balance of effects Favors the comparison Probably favors the comparison Does not favor either the intervention or the comparison Probably favors the intervention Favors the intervention Varies Don't know Resources required Large costs Moderate costs Negligible costs and savings Moderate savings Large savings Varies Don't know Certainty of evidence of required resources Very low Low Moderate High No included studies Cost effectiveness Favors the comparison Probably favors the comparison Does not favor either the intervention or the comparison Probably favors the intervention Favors the intervention Varies No included studies Equity Reduced Probably reduced Probably no impact Probably increased Increased Varies Don't know Acceptability No Probably no Probably yes Yes Varies Don't know Feasibility No Probably no Probably yes Yes Varies Don't know Conclusions Should an alpha-2 agonist (e.g., dexmedetomidine) vs. propofol be used in critially ill ventilated adults (both intubated and