For both conventions, subjects who completed the study or who had not relapsed were considered as censored. Numbers of subjects (%) who discontinued prematurely are given in Table 19 below, with reasons. Table 19. Study RD.03.SRE.40037. Numbers of subjects (%) who discontinued prematurely. Ivermectin 0.1% 0.3% 1% 1% BD 0.75% daily daily daily daily BD No. enrolled 28 27 31 26 20 17 No. completed 18 18 21 21 12 11 (64.3) (66.7) (67.7) (80.8) (60.0) (64.7) Days Premature All 1 (3.6) 2 (7.4) 2 (6.5) 3 (15.0) 1 (5.9) discontinuation 29-56 Other 1 (3.7) Protocol 1 (5.0) violation Subject 1 (3.6) 1 (3.7) 2 (6.5) 2 (10.0) 1 (5.9) request Days Premature All 3 1 (3.7) 3 (9.7) 1 (3.8) 3 (15.0) 2 (10.7) (11.8) 57-84 discontinuation 2 (7.1) 2 (10.0) 1 (5.9) Subject 1 (3.6) 3 (9.7) 1 (3.8) 1 (5.0) 1 (5.9) request Days Premature All 4 3 3 (9.7) 2 (7.7) 2 (10.0) 3 discontinuation (14.3) (11.1) (17.6) Other 2 (6.5) 1 (3.8) Subject 4 3 1 (3.2) 1 (3.8) 2 (10.0) 3 request (14.3) (11.1) (17.6) Days Premature All 2 (7.4) 2 (7.7) discontinuation Subject 2 (7.4) 2 (7.7) request Days Premature All 2 (7.1) 1 (3.7) 2 (6.5) discontinuation 141 ≥ Other 1 (3.7) 2 (6.5) Subject 2 (7.1) request
For both conventions, subjects who completed the study or who had not relapsed were considered as censored. Numbers of subjects (%) who discontinued prematurely are given in Table 19 below, with reasons. Table 19. Study RD.03.SRE.40037. Numbers of subjects (%) who discontinued prematurely. Ivermectin 0.1% daily 0.3% daily 1% daily 1% BD 0.75% BD daily No. enrolled 28 27 31 26 20 17 No. completed 18 (64.3) 18 (66.7) 21 (67.7) 21 (80.8) 12 (60.0) 11 (64.7) Days 29-56 Premature discontinuation All 1 (3.6) 2 (7.4) 2 (6.5) 3 (15.0) 1 (5.9) Other 1 (3.7) Protocol violation 1 (5.0) Subject request 1 (3.6) 1 (3.7) 2 (6.5) 2 (10.0) 1 (5.9) Days 57-84 Premature discontinuation All 3 (10.7) 1 (3.7) 3 (9.7) 1 (3.8) 3 (15.0) 2 (11.8) 2 (7.1) 2 (10.0) 1 (5.9) Subject request 1 (3.6) 3 (9.7) 1 (3.8) 1 (5.0) 1 (5.9) Days Premature discontinuation All 4 (14.3) 3 (11.1) 3 (9.7) 2 (7.7) 2 (10.0) 3 (17.6) Other 2 (6.5) 1 (3.8) Subject request 4 (14.3) 3 (11.1) 1 (3.2) 1 (3.8) 2 (10.0) 3 (17.6) Days Premature discontinuation All 2 (7.4) 2 (7.7) Subject request 2 (7.4) 2 (7.7) Days ≥ 141 Premature discontinuation All 2 (7.1) 1 (3.7) 2 (6.5) Other 1 (3.7) 2 (6.5) Subject request 2 (7.1)