SEW 05581 -8.011.791 BTB -8.005.782 XBX 00010 -8.004.911 RDR 03349 -8.002.685 JFD 00177 -6.862.477 DP00605 -5.981.074 DP 00603 -5.883.971 DP 00604 -5.580.471 Table SI2. Structure, Maybridge Codes and RET Inhibitory Activity of Test Compounds. IC50 on Inhibition % N° Compound Structure Code RET (100 μM)a (μM)b 7 JFD00177 12.1 8 JFD00159 20.9 9 HTS02812 54.0 CD03535 63.8 10 11 JFD02380 68.4 12 XBX00307 78.1 13 HTS08709 82.6 14 DP01247 52
SEW 05581 -8.011.791 BTB -8.005.782 XBX 00010 -8.004.911 RDR 03349 -8.002.685 JFD 00177 -6.862.477 DP00605 -5.981.074 DP 00603 -5.883.971 DP 00604 -5.580.471 Table SI2. Structure, Maybridge Codes and RET Inhibitory Activity of Test Compounds. N° Compound Structure Code Inhibition % (100 μM)a IC50 on RET (μM)b 7 JFD00177 12.1 8 JFD00159 20.9 9 HTS02812 54.0 10 CD03535 63.8 11 JFD02380 68.4 12 XBX00307 78.1 13 HTS08709 82.6 14 DP01247 52