Cohort III-2 4,746 Aim: To compare incidence of congenital syphilis The incidence of congenital syphilis was Confidence (Hong et al mother following different treatment regimens or no 1.82–11.90% lower among infants born to intervals are very 2017) infant treatment. the women treated with early (<28 wks) wide and, for pairs benzathine penicillin G (BPG) compared other antibiotics, Setting: China with those treated with late (≥28 wks) BPG cross the line of Methods: We obtained data from the Shenzhen (aOR 8.06; 95%CI 2.93 to 22.21; P <0.001), no effect. Program for Prevention of Congenital Syphilis other antibiotics (aOR 7.71; 95%CI 0.86 to Stillbirths (SPPCS) and estimated incidence rates of 69.28; P=0.068), or those untreated (aOR attributable to congenital syphilis among infants born to 68.28; 95%CI 29.64 to 157.28; P < 0.001). maternal syphilis women treated with different The incidence rates were 0.22% (95%CI 0.06 were absent from regimens or untreated for maternal syphilis. to 0.80%) and 0.59% (95%CI 0.35 to 1.02%) the criteria of in infants born to women treated with 2 congenital courses and 1 course of BPG, respectively, syphilis, corresponding to a risk difference of 0.37% potentially (aOR 1.74; 95%CI 0.37 to 8.26). resulting in an underestimation of risk
(Hong et al 2017) Cohort III-2 4,746 mother infant pairs Aim: To compare incidence of congenital syphilis following different treatment regimens or no treatment. Setting: China Methods: We obtained data from the Shenzhen Program for Prevention of Congenital Syphilis (SPPCS) and estimated incidence rates of congenital syphilis among infants born to women treated with different regimens or untreated for maternal syphilis. The incidence of congenital syphilis was 1.82–11.90% lower among infants born to the women treated with early (<28 wks) benzathine penicillin G (BPG) compared with those treated with late (≥28 wks) BPG (aOR 8.06; 95%CI 2.93 to 22.21; P <0.001), other antibiotics (aOR 7.71; 95%CI 0.86 to 69.28; P=0.068), or those untreated (aOR 68.28; 95%CI 29.64 to 157.28; P < 0.001). The incidence rates were 0.22% (95%CI 0.06 to 0.80%) and 0.59% (95%CI 0.35 to 1.02%) in infants born to women treated with 2 courses and 1 course of BPG, respectively, corresponding to a risk difference of 0.37% (aOR 1.74; 95%CI 0.37 to 8.26). Confidence intervals are very wide and, for other antibiotics, cross the line of no effect. Stillbirths attributable to maternal syphilis were absent from the criteria of congenital syphilis, potentially resulting in an underestimation of risk