who was insufficiency, number of days unaware of the use of that stockings results of the were worn during venous meds, previous a week were 6.3 examination the venous for patients with severity of PTS insufficiency, PTS (p = 0.63). was scored surgery, trauma according to the or pregnancy in clinical score the 4 weeks (range 0-6). prior to the Class 0 DVT and the represents no use of LMWH visible or or oral palpable signs of anticoagulation PTS. before blood sampling. Aissaoui, N., To compare Meta-analysis 5 studies When compared Martins, E., ambulation considers included a total to bed rest, early Mouly, S., versus bed rest, randomized of 3048 ambulation was Weber, S., in addition to control trials and patients. not associated Meune, C. anticoagulation, prospective with a higher (2009). A in the registries. incidence of a new of bed management of Compared the PE (RR 1.03; 95% rest versus early DVT and PE. outcomes of CI 0.65-1.63; p = ambulation in the patients with 0.90). Early management of DVT, PE, or ambulation was pulmonary both, managed associated with a embolism, deep with bed rest trend toward a vein thrombosis versus early lower incidence of or both. ambulation in a new PE and new addition to or progression of International anticoagulation. DVT than bed rest Journal of For each study, (RR 0.79; 95% CI Cardiology, 137, 37-41. data regarding 0.55-1.14; p = the incidence of 0.21) and lower new PE, new or incidence of new progression of PE and overall DVT, and death mortality (RR from all causes 0.79; 95% CI were used to 0.402-1.56; p = calculate relative 0.50). risks (RR) and 95% confidence intervals (CI). Trujillo-Santos et To compare the 15 day study. 2,650 patients New events of al. (2005). Bed clinical (DVT, 2,038 symptomatic,
who was unaware of the results of the venous examination the severity of PTS was scored according to the clinical score (range 0-6). Class 0 represents no visible or palpable signs of PTS. insufficiency, use of meds, previous venous insufficiency, surgery, trauma or pregnancy in the 4 weeks prior to the DVT and the use of LMWH or oral anticoagulation before blood sampling. number of days that stockings were worn during a week were 6.3 for patients with PTS (p = 0.63). Aissaoui, N., Martins, E., Mouly, S., Weber, S., Meune, C. (2009). A of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis or both. International Journal of Cardiology, 137, 37-41. To compare ambulation versus bed rest, in addition to anticoagulation, in the management of DVT and PE. Meta-analysis considers randomized control trials and prospective registries. Compared the outcomes of patients with DVT, PE, or both, managed with bed rest versus early ambulation in addition to anticoagulation. For each study, data regarding the incidence of new PE, new or progression of DVT, and death from all causes were used to calculate relative risks (RR) and 95% confidence intervals (CI). 5 studies included a total of 3048 patients. When compared to bed rest, early ambulation was not associated with a higher incidence of a new PE (RR 1.03; 95% CI 0.65-1.63; p = 0.90). Early ambulation was associated with a trend toward a lower incidence of a new PE and new or progression of DVT than bed rest (RR 0.79; 95% CI 0.55-1.14; p = 0.21) and lower incidence of new PE and overall mortality (RR 0.79; 95% CI 0.402-1.56; p = 0.50). Trujillo-Santos et al. (2005). Bed To compare the clinical 15 day study. 2,650 patients (DVT, 2,038 New events of symptomatic,