Setting: Intensive care unit Criteria Judgements Research evidence Problem Is there a problem No The evidence for this recommendation comes from a single study (Reade et al, 2016) : 77 ○ priority? Probably no patients >18 yo who only required MV due to the degree of agitation (need for restraint, ○ Uncertain antipsychotic or sedative + CAM-ICU positive + MAAS score of 5 or greater) were ○ Probably yes recruited from 15 ICU's in Aus. and NZ and randomized to dexmedetomidine (n=39) or ○ Yes placebo (n= 32). Note is made that 21,500 intubated patients were screened to recruit the ● Varies patients in this study; also the sponsor stopped the study before recruitment was ○ completed. Benefits & What is the overall No included studies ○ harms of the Very low certainty of this The relative importance or values of the ○ options evidence? Low ● Moderate ○ High ○ Is there important Important uncertainty ○ uncertainty about or variability how much people Possibly important ○ uncertainty or variability value the main outcomes? Probably no important ● uncertainty or variability No important ○ uncertainty or variability
Setting: Intensive care unit Criteria Judgements Research evidence Problem Is there a problem priority? ○ No ○ Probably no ○ Uncertain ○ Probably yes ● Yes ○ Varies The evidence for this recommendation comes from a single study (Reade et al, 2016) : 77 patients >18 yo who only required MV due to the degree of agitation (need for restraint, antipsychotic or sedative + CAM-ICU positive + MAAS score of 5 or greater) were recruited from 15 ICU's in Aus. and NZ and randomized to dexmedetomidine (n=39) or placebo (n= 32). Note is made that 21,500 intubated patients were screened to recruit the patients in this study; also the sponsor stopped the study before recruitment was completed. Benefits & harms of the options What is the overall certainty of this evidence? ○ No included studies ○ Very low ● Low ○ Moderate ○ High The relative importance or values of the Is there important uncertainty about how much people value the main outcomes? ○ Important uncertainty or variability ○ Possibly important uncertainty or variability ● Probably no important uncertainty or variability ○ No important uncertainty or variability