19 20 than two affected family members with testicular cancer. The prevalence of TML was 21 22 23 significantly higher among cases than among unaffected men (48% vs. 24%; p= 0.04). 24 25 No cancer was found in the group of relatives with TML (8 of 33 relatives) [36]. 26 27 28 Coffey et al. analysed ultrasound data of 328 men (169 testicular cancer cases; 58 29 30 31 relatives to the 101 controls). A greater concordance for TML in relatives of 32 33 testicular cancer cases than would be expected was demonstrated. No testicular cancer 34 35 36 case was found in the group of relatives, whereas 1 testicular cancer was found in the 37 38 39 control group and 3 in the remaining testis of the case group (Table 5). Overall TML 40 41 was present with a higher frequency in cases with prior testicular cancer (36.7%) 42 43 44 compared to controls (17.8%) [37]. 45 46 47 48 49 Discussion 50 51 Males with Down syndrome and McCune Albright syndrome appear to have the 52
19 20 21 than two affected family members with testicular cancer. The prevalence of TML was 22 23 24 significantly higher among cases than among unaffected men (48% vs. 24%; p= 0.04). 25 26 No cancer was found in the group of relatives with TML (8 of 33 relatives) [36]. 27 28 29 Coffey et al. analysed ultrasound data of 328 men (169 testicular cancer cases; 58 30 31 32 relatives to the 101 controls). A greater concordance for TML in relatives of 33 34 testicular cancer cases than would be expected was demonstrated. No testicular cancer 35 36 37 case was found in the group of relatives, whereas 1 testicular cancer was found in the 38 39 40 control group and 3 in the remaining testis of the case group (Table 5). Overall TML 41 42 was present with a higher frequency in cases with prior testicular cancer (36.7%) 43 44 45 compared to controls (17.8%) [37]. 46 47 48 49 50 Discussion 51 52 Males with Down syndrome and McCune Albright syndrome appear to have the