Pre-eclampsia and hypertension Study ref Evidence Sample Setting/population Findings Comments Level size () II 280 Pregnant women at 11-13 Markers for pre-eclampsia (MAP [p=0.85]; UtA PI Deficiency: weeks' gestation, of whom [p=0.36], PlGF [p=0.08], PAPP-A [p=0.92]) were not 25(OH)D < 20 75% used vitamin related to the maternal serum 25OHD ng/ml (54%) supplementation. concentration. Insufficiency: There were five cases of pregnancy-induced 20-30 ng/ml (34%) hypertension (one with proteinuria) in vitamin D Sufficiency: >30 deficiency group as compared to one case in ng/ml (11%) women with 25OHD>20 ng/ml. () II 5,109 Study was conducted on the Women with low 25(OH)D concentrations had a The median (IQR) basis of a study population of reduced risk of preeclampsia (P = 0.07). 25(OH)D Australian 11,358 women who were concentration for study There was also a slight tendency for high 25(OH)D attending first-trimester Down the total concentrations >75 nmol/L to be protective syndrome screening between population was against early-onset preeclampsia (P = 0.09); October 2006 and September 56.4 nmol/L however, numbers were small, and results were 2007 in NSW. nmol/L). imprecise. Cases of each study outcome of interest (SGA, preterm birth, preeclampsia, GD, miscarriage, and stillbirth) were randomly selected from the maternal screening population. Controls were sourced using a method that ensured the random blinded selection of samples.
Pre-eclampsia and hypertension Study ref Evidence Level Sample size Setting/population Findings Comments () II 280 Pregnant women at 11-13 weeks' gestation, of whom 75% used vitamin supplementation. Markers for pre-eclampsia (MAP [p=0.85]; UtA PI [p=0.36], PlGF [p=0.08], PAPP-A [p=0.92]) were not related to the maternal serum 25OHD concentration. There were five cases of pregnancy-induced hypertension (one with proteinuria) in vitamin D deficiency group as compared to one case in women with 25OHD>20 ng/ml. Deficiency: 25(OH)D < 20 ng/ml (54%) Insufficiency: 20-30 ng/ml (34%) Sufficiency: >30 ng/ml (11%) () II Australian study 5,109 Study was conducted on the basis of a study population of 11,358 women who were attending first-trimester Down syndrome screening between October 2006 and September 2007 in NSW. Cases of each study outcome of interest (SGA, preterm birth, preeclampsia, GD, miscarriage, and stillbirth) were randomly selected from the maternal screening population. Controls were sourced using a method that ensured the random blinded selection of samples. Women with low 25(OH)D concentrations had a reduced risk of preeclampsia (P = 0.07). There was also a slight tendency for high 25(OH)D concentrations >75 nmol/L to be protective against early-onset preeclampsia (P = 0.09); however, numbers were small, and results were imprecise. The median (IQR) 25(OH)D concentration for the total population was 56.4 nmol/L nmol/L).