vermiculite ore within an industrial process cause pleural thickening at low lifetime cumulative fibre exposure levels of <2.21 fibre/mL-year. Paris et al RMA ID: Factors 706 retired Asbestos Cumulative Fibre Duration of Asbestos Radiological (2004) 067600 Associated workers textile and exposure: concentration exposure: reporting exposure with exposed to friction N=706; method used: N=706; relationship between producing asbestos (89% material M=137.9 (SD For the M=24.9 asbestos exposure asbestosis seen Pulmonary men) factory, =136.4) participants (SD=9.1) and HRCT findings at 25-99.9 Fibrosis as shipyards, fibre/mL-year who had fibre/mL-year 51=pulmonary There were 51 Determined by fossil fuel worked in the fibrosis 2- 112 pulmonary fibrosis power asbestos bilateral participants (grade 2 or 3; different Resolution stations, and textile and interstitial (16%)=<25 scoring system to ILO) Computed industrial friction abnormalities fibre/mL-year diagnosed by HRCT. Tomography insulation material plant limited in extent Only 2 Only 38 diagnosed Among a specific but consistent subjects with with pulmonary fibrosis Persons with HRCT according to American Occupationally matrix related pulmonary Thoracic Society Exposed to determined pulmonary fibrosis criteriab, 9 which were Asbestos from air-borne fibrosis or grade exposed to diagnosed by HRCT samples 3-profuse <25 For 112 participants collected bilateral (9.3 and the cumulative annually interstitial 15 exposure level was between 1959 abnormalities <25 fibre/mL-year of and 1999 in visible on respectively) which 2 subjects had the various several slices) 52 participants HRCT asbestosis workshops of diagnosed by with <25 Significant association the plant. HRCT (only 38 fibre/mL-year between HRCT diagnosed For all the had no fibrosis and cumulative asbestosis - other symptoms or asbestos exposure, small opacity participants, abnormal with a clear dose-
vermiculite ore within an industrial process cause pleural thickening at low lifetime cumulative fibre exposure levels of <2.21 fibre/mL-year. Paris et al (2004) RMA ID: 067600 Factors Associated with Pulmonary Fibrosis as Determined by Computed Tomography Among Persons Occupationally Exposed to Asbestos 706 retired workers exposed to asbestos (89% men) 51=pulmonary fibrosis 2- bilateral interstitial abnormalities limited in extent but consistent with pulmonary fibrosis or grade 3-profuse bilateral interstitial abnormalities visible on several slices) diagnosed by HRCT (only 38 diagnosed asbestosis - small opacity Asbestos textile and friction material factory, shipyards, fossil fuel power stations, and industrial insulation Cumulative exposure: N=706; M=137.9 (SD =136.4) fibre/mL-year 112 participants (16%)=<25 fibre/mL-year Only 2 subjects with HRCT pulmonary fibrosis exposed to <25 (9.3 and 15 respectively) 52 participants with <25 fibre/mL-year had no symptoms or abnormal Fibre concentration method used: For the participants who had worked in the asbestos textile and friction material plant a specific matrix determined from air-borne samples collected annually between 1959 and 1999 in the various workshops of the plant. For all the other participants, Duration of exposure: N=706; M=24.9 (SD=9.1) Radiological reporting relationship between asbestos exposure and HRCT findings There were 51 pulmonary fibrosis (grade 2 or 3; different scoring system to ILO) diagnosed by HRCT. Only 38 diagnosed with pulmonary fibrosis according to American Thoracic Society criteriab, 9 which were diagnosed by HRCT For 112 participants the cumulative exposure level was <25 fibre/mL-year of which 2 subjects had HRCT asbestosis Significant association between HRCT fibrosis and cumulative asbestos exposure, with a clear Asbestos exposure producing asbestosis seen at 25-99.9 fibre/mL-year Resolution related dose-