Table 232 Dietary vitamin E and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response analysis Author, Year, Missing data Study name, Study size Case Exposure RR (95%CI) Adjustment WCRF Code, Outcome Comparison derived for characteristics Follow-up ascertainment assessment Ptrend factors Country (years) Alcohol Leenders, 2014 EPIC, 898/ Cancer registry FFQ Incidence, colon vs ≥13 ≤8 0.99 (0.74-1.33) consumption, COL41012 Nested Case 898 controls cancer mg/day educational Europe Control, 501/ Incidence, rectal matching Age: 35-70 501 controls cancer variables, years, number of M/W cigarettes smoked, physical vs activity, ≥13 ≤8 1.11 (0.74-1.65) mg/day smoking duration, smoking status, time since smoking cessation, waist circumference Park, 2010 Age, body mass Studies 5454/676141 index, Pooling Project ATBC 44 education, CPS II 467+349 physical HPFS 456 activity, family Self-reported NLCS 393 history of questionnaire Incidence, colon NYSC 335+223 FFQ Q5 vs Q1 0.99(0.89-1.11) colorectal and medical cancer cancer, use of BCDDP 349 record nonsteroidal CNBSS 431 IWHS 799 NLCS 353 drugs, NYUWHS 96 multivitamin
Table 232 Dietary vitamin E and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response Author, Year, WCRF Code, Country Study name, characteristics Study size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Missing data derived for Leenders, 2014 COL41012 Europe EPIC, Nested Case Control, Age: 35-70 years, M/W 898/ 898 controls Cancer registry FFQ Incidence, colon cancer ≥13 vs ≤8 mg/day 0.99 (0.74-1.33) Alcohol consumption, educational matching variables, number of cigarettes smoked, physical activity, smoking duration, smoking status, time since smoking cessation, waist circumference 501/ 501 controls Incidence, rectal cancer ≥13 vs ≤8 mg/day 1.11 (0.74-1.65) Park, 2010 Pooling Project Studies ATBC CPS II HPFS NLCS NYSC BCDDP CNBSS IWHS NLCS NYUWHS 5454/676141 44 467+349 456 393 335+223 349 431 799 353 96 Self-reported questionnaire and medical record FFQ Incidence, colon cancer Q5 vs Q1 0.99(0.89-1.11) Age, body mass index, education, physical activity, family history of colorectal cancer, use of nonsteroidal drugs, multivitamin analysis