PGI2 Prostacyclin P-gp P-glycoprotein PI phototoxic index PK Pharmacokinetics PND day PO per os (oral (gavage)) PopPK/PD population pharmacokinetic(s)/pharmacodynamic(s) PPS Per-protocol set PR Pulse rate P-selectin platelet-selectin PT prothrombin time PT AUC0-144h area under the PT versus time curve to 144 h post dose PT Preferred term PVR pulmonary vascular resistance QAS Quality of Life analysis set QoL Quality of Life QTc QT interval corrected for trial rate QTcB QT interval corrected with Bazett’s formula QTcF QT interval corrected with Fridericia’s formula QTcI QT interval corrected using the individualised formula RBC Red trial cell RR R-to-R interval SC Subcutaneous SAE serious adverse event SAEM stochastic approximation expectation maximisation SAF Safety analysis set SAS statistical analysis system (software)
PGI2 Prostacyclin P-gp P-glycoprotein PI phototoxic index PK Pharmacokinetics PND day PO per os (oral (gavage)) PopPK/PD population pharmacokinetic(s)/pharmacodynamic(s) PPS Per-protocol set PR Pulse rate P-selectin platelet-selectin PT prothrombin time PT AUC0-144h area under the PT versus time curve to 144 h post dose PT Preferred term PVR pulmonary vascular resistance QAS Quality of Life analysis set QoL Quality of Life QTc QT interval corrected for rate QTcB QT interval corrected with Bazett’s formula QTcF QT interval corrected with Fridericia’s formula QTcI QT interval corrected using the individualised formula RBC Red cell RR R-to-R interval SC Subcutaneous SAE serious adverse event SAEM stochastic approximation expectation maximisation SAF Safety analysis set SAS statistical analysis system (software) trial trial