Table 106 Dairy intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, Study name, Case Missing data Study size Exposure WCRF Code, Outcome Comparison RR (95%CI) Adjustment factors derived for Follow-up assessment Country analysis (years) Incidence, vs ≥490 colorectal 0.77 (0.70-0.86) g/d cancer Incidence, per 400 colorectal 0.86 (0.79-0.93) g/day cancer Incidence, vs ≥490 0.75 (0.66-0.86) Age, alcohol colon cancer g/d consumption, BMI, Incidence, per 400 centre location, 0.94 (0.91-0.97) cancer g/day educational level, Cancer fibre intake, Incidence, Murphy, 2013 EPIC, registries, vs ≥490 menopausal proximal 0.75 (0.62-0.91) COL41070 Prospective health g/d 4 513/ Dietary hormone use, colon cancer Cohort, Insurance 477 122 menopausal status, Midpoints Age: 30- records, Incidence, 11 years e physical activity per 400 years, pathology proximal 0.95 (0.89-1.01) Index, red and g/day M/W rec & active colon cancer processed meat, follow up smoking status and Incidence, vs dose, total energy ≥490 distal colon 0.74 (0.61-0.90) g/d intake, use of cancer contraception Incidence, per 400 distal 0.94 (0.88-0.99) g/day cancer Incidence, vs ≥490 0.81 (0.69-0.96) rectal cancer g/d Incidence, per 400 0.95 (0.90-1.00) rectal cancer g/day
Table 106 Dairy intake and colorectal cancer risk. Main characteristics of studies included in the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, Study size Follow-up (years) Case Exposure assessment Outcome Comparison RR (95%CI) Adjustment factors Missing data derived for analysis Murphy, 2013 COL41070 EPIC, Prospective Cohort, Age: 30- years, M/W 4 513/ 477 122 11 years Cancer registries, health Insurance records, pathology rec & active follow up Dietary Incidence, colorectal cancer ≥490 vs g/d 0.77 (0.70-0.86) Age, alcohol consumption, BMI, centre location, educational level, fibre intake, menopausal hormone use, menopausal status, physical activity Index, red and processed meat, smoking status and dose, total energy intake, use of contraception Midpoints Incidence, colorectal cancer per 400 g/day 0.86 (0.79-0.93) Incidence, colon cancer ≥490 vs g/d 0.75 (0.66-0.86) Incidence, cancer per 400 g/day 0.94 (0.91-0.97) Incidence, proximal colon cancer ≥490 vs g/d 0.75 (0.62-0.91) Incidence, proximal colon cancer per 400 g/day 0.95 (0.89-1.01) Incidence, distal colon cancer ≥490 vs g/d 0.74 (0.61-0.90) Incidence, distal cancer per 400 g/day 0.94 (0.88-0.99) Incidence, rectal cancer ≥490 vs g/d 0.81 (0.69-0.96) Incidence, rectal cancer per 400 g/day 0.95 (0.90-1.00) e