Figure Legends Figure 1 - Example workflow for identifying significant coregulation Figure 2 - Example workflow for constructing functional coregulation network For each coregulation pair, a function linkage was established if a GO term enriched in their shared targets. The coregulation network was generated based on these function linkages. Nodes represent regulators, and edge represents GO terms, marked with different colours. Figure 3 - Distributions of enriched biological processes for different regulation types (A) Distributions for TF-involving regulation: individual TFs, TF-TF pairs, and TF-miRNA pairs. (B) Distributions for miRNA-involving regulation: individual miRNAs, pairs, and TF-miRNA pairs. Note that the same TF-miRNA line are drawn in both (A) and (B) for comparison. Figure 4 - Functional coregulation networks (A) TF-TF coregulation network. (B) miR-miR coregulation network. (C) TF-miR coregulation network. Red nodes represent TFs; green nodes represent miRNAs; and edges represent biological processes. Different edge colours represent different biological processes. Figure 5 - Network motifs for TF-TF and TF-miRNA coregulation pairs For each motif, the observation number and the percentage of pairs that have this motif were reported, along with the and one instance coregulation pair. P-value Figure 6 - Distributions of expression correlation for different types of coregulation pairs Left column for normal tissues; right column for tumor tissues. Rows are in the order of TF-miR, and miR-miR coregulation pairs. Additional files Additional file 1 List of all function-enriched coregulation pairs –
Figure Legends Figure 1 - Example workflow for identifying significant coregulation Figure 2 - Example workflow for constructing functional coregulation network For each coregulation pair, a function linkage was established if a GO term enriched in their shared targets. The coregulation network was generated based on these function linkages. Nodes represent regulators, and edge represents GO terms, marked with different colours. Figure 3 - Distributions of enriched biological processes for different regulation types (A) Distributions for TF-involving regulation: individual TFs, TF-TF pairs, and TF-miRNA pairs. (B) Distributions for miRNA-involving regulation: individual miRNAs, pairs, and TF-miRNA pairs. Note that the same TF-miRNA line are drawn in both (A) and (B) for comparison. Figure 4 - Functional coregulation networks (A) TF-TF coregulation network. (B) miR-miR coregulation network. (C) TF-miR coregulation network. Red nodes represent TFs; green nodes represent miRNAs; and edges represent biological processes. Different edge colours represent different biological processes. Figure 5 - Network motifs for TF-TF and TF-miRNA coregulation pairs For each motif, the observation number and the percentage of pairs that have this motif were reported, along with the P-value and one instance coregulation pair. Figure 6 - Distributions of expression correlation for different types of coregulation pairs Left column for normal tissues; right column for tumor tissues. Rows are in the order of TF-miR, and miR-miR coregulation pairs. Additional files Additional file 1 – List of all function-enriched coregulation pairs