219 Alcohol (as ethanol) and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Cases/ Author, Year, Study name, size Case Exposure RR (95%CI) Adjustment Reasons for WCRF Code, Outcome Comparison characteristics Follow-up ascertainment assessment Ptrend factors exclusion Country (years) Framingham Heart Study - Insufficient data to include Makarem, 2015 63/ Death certificate Cohort, Incidence, per 1 points Age, sex, smoking in analysis COL41060 2 983 and medical 0.29 (0.15-0.56) Prospective FFQ colorectal cancer WCRF score status (include in USA 11.5 years records Cohort, dietary patterns Age: 66 years, section) M/W Age, aspirin use, Incidence, 573/ BMI, calcium, colorectal vs g/day 1.10 (0.83-1.45) ≥15 ≤0 endoscopy, family cancer, women history of NHS-HPFS, colorectal cancer, Nan, 2013 Prospective folate, COL40971 Cohort, Nishihara, 2014 Medical records methionine, was used Age: 30-75 COL41036 and death multivitamin, years, FFQ because has USA registries pack yrs of M/W, higher number 420/ Men vs g/day 1.39 (1.04-1.84) smoking, physical ≥15 ≤0 nurses & health of activity, red meat, professionals total caloric intake, vitamin b12, vitamin b6, year EPIC, 2 002/ Cancer registry limited vs heavy 0.96 (0.87-1.07)
219 Alcohol (as ethanol) and colorectal cancer risk. Main characteristics of studies excluded from the CUP SLR dose-response meta-analysis Author, Year, WCRF Code, Country Study name, characteristics Cases/ size Follow-up (years) Case ascertainment Exposure assessment Outcome Comparison RR (95%CI) Ptrend Adjustment factors Reasons for exclusion Makarem, 2015 COL41060 USA Framingham Heart Study - Cohort, Prospective Cohort, Age: 66 years, M/W 63/ 2 983 11.5 years Death certificate and medical records FFQ Incidence, colorectal cancer per 1 points WCRF score 0.29 (0.15-0.56) Age, sex, smoking status Insufficient data to include in analysis (include in dietary patterns section) Nishihara, 2014 COL41036 USA NHS-HPFS, Prospective Cohort, Age: 30-75 years, M/W, nurses & health professionals 573/ Medical records and death registries FFQ Incidence, colorectal cancer, women ≥15 vs ≤0 g/day 1.10 (0.83-1.45) Age, aspirin use, BMI, calcium, endoscopy, family history of colorectal cancer, folate, methionine, multivitamin, pack yrs of smoking, physical activity, red meat, total caloric intake, vitamin b12, vitamin b6, year Nan, 2013 COL40971 was used because has higher number of 420/ Men ≥15 vs ≤0 g/day 1.39 (1.04-1.84) EPIC, 2 002/ Cancer registry limited vs heavy 0.96 (0.87-1.07)