66 Processed meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Total Studies Number of Heterogeneity Author, Year number of country, Outcome Comparison RR (95%CI) P trend cohort studies (I2, p value) cases area Pooled analysis 7 nested control studies North HPFS, MEC, NHS, 3 488 Colorectal cancer 1.48 (1.30–1.70) Kantor, 2014 Per 1 serving/day America PHS, PLCO, VITAL, WHI 7 0.76 (0.56–1.03) vs <5 g/day ≥30 Colorectal cancer 0.36 Guernsey Per 50g/day 0.88 (0.68–1.15) Norfolk, 0.90 (0.62–1.31) vs <5 g/day ≥30 Colon cancer 0.94 EPIC-Oxford, Per 50g/day 1.01 (0.73–1.40) 579 cases NSHD, Oxford 1996 Spencer, 2010 UK Vegetarian controls Study 0.50 (0.29–0.85) vs <5 g/day ≥30 Rectal cancer 0.07 Oxford Vegetarian Per 50g/day 0.65 (0.40–1.04) UKWCS, Whitehall II Meta-analysis Colorectal, colon Europe, 9 and rectal cancer 1.10 (1.05-1.15) Alexander, 2010 30g/day Asia and combined
66 Processed meat and colorectal cancer risk. Results of meta-analyses and pooled analyses of prospective studies published after the 2005 SLR. Author, Year Number of cohort studies Total number of cases Studies country, area Outcome Comparison RR (95%CI) P trend Heterogeneity (I2, p value) Pooled analysis Kantor, 2014 7 nested studies HPFS, MEC, NHS, PHS, PLCO, VITAL, WHI 3 488 North America Colorectal cancer Per 1 serving/day 1.48 (1.30–1.70) Spencer, 2010 7 Guernsey Norfolk, EPIC-Oxford, NSHD, Oxford Vegetarian Study Oxford Vegetarian UKWCS, Whitehall II 579 cases 1996 controls UK Colorectal cancer ≥30 vs <5 g/day Per 50g/day 0.76 (0.56–1.03) 0.88 (0.68–1.15) 0.36 Colon cancer ≥30 vs <5 g/day Per 50g/day 0.90 (0.62–1.31) 1.01 (0.73–1.40) 0.94 Rectal cancer ≥30 vs <5 g/day Per 50g/day 0.50 (0.29–0.85) 0.65 (0.40–1.04) 0.07 Meta-analysis Alexander, 2010 9 Europe, Asia and Colorectal, colon and rectal cancer combined 30g/day 1.10 (1.05-1.15) control