Continued Table 1 Characteristics of the included patients Squadrone et al., Ferrer et al., Hilbert et al., Delclaux et al., Antonelli et al., 2005 [21] 2003 [24] 2001 [23] 2000 [25] 2000 [26] Populations Enrollment 2002.06-2003.11 NA 1998.05-1999.12 1997.09-1999.01 1995.12-1997.10 period Total number of 209 75 52 81 31 included patients Study center 15 ICUs in Italy 3 ICUs in Spain 1 ICU in France 6 ICUs in France, 1 ICU in Spain, Tunisia and Italy Enrollment Severe AHRF, defined (1)A clinical history of (1) acute respiratory respiratory PaO2/FiO2≤300mmHg as PaO2 persistently pulmonary infiltrates insufficiency, defined as distress criteria and (more than 6 to 8 and PaO2/FIO2 mm Hg (2)RR≥ 35/min, ≤300 definition in the hours) < 60mmHg or (2)severe dyspnea at rest (oxygen at 10 L/min or PaO2/FiO2<200 while trials SaO2 <90% (3)PaO2/FiO2<200. more for 15 minutes), the patient was persistently while (2) the presence of breathing oxygen breathing conventional bilateral lung infiltrates on through a Venturi mask; Venturi oxygen at a a posteroanterior chest (3) active contraction of maximal concentration radiograph; the accessory muscles (50%) (3) Randomization within of respiration or 3 hours after the criteria paradoxical abdominal were first fulfilled. motion. 65.5 61.5 49 58 44.5 Mean age (yr) Design RCT RCT RCT RCT RCT Severity at enrollment (mean) PH 7.39 7.41 7.44 7.42 7.45 PaO2/FiO2 251 102.5 138.5 144 129 (mean, mmHg) 39 36.5 37.5 36 40 (mean, mmHg) SAPS II 27.5 33.5 43.5 32 NA SOFA score NA NA NA NA NA
Continued Table 1 Characteristics of the included patients Squadrone et al., 2005 [21] Ferrer et al., 2003 [24] Hilbert et al., 2001 [23] Delclaux et al., 2000 [25] Antonelli et al., 2000 [26] Populations Enrollment period 2002.06-2003.11 NA 1998.05-1999.12 1997.09-1999.01 1995.12-1997.10 Total number of included patients 209 75 52 81 31 Study center 15 ICUs in Italy 3 ICUs in Spain 1 ICU in France 6 ICUs in France, Spain, Tunisia and Italy 1 ICU in Enrollment criteria and definition in the trials PaO2/FiO2≤300mmHg Severe AHRF, defined as PaO2 persistently (more than 6 to 8 hours) < 60mmHg or SaO2 <90% persistently while breathing conventional Venturi oxygen at a maximal concentration (50%) (1)A clinical history of pulmonary infiltrates and (2)severe dyspnea at rest (3)PaO2/FiO2<200. (1) acute respiratory insufficiency, defined as PaO2/FIO2 ≤300 mm Hg (oxygen at 10 L/min or more for 15 minutes), (2) the presence of bilateral lung infiltrates on a posteroanterior chest radiograph; (3) Randomization within 3 hours after the criteria were first fulfilled. respiratory distress (2)RR≥ 35/min, PaO2/FiO2<200 while the patient was breathing oxygen through a Venturi mask; (3) active contraction of the accessory muscles of respiration or paradoxical abdominal motion. Mean age (yr) 65.5 61.5 49 58 44.5 Design RCT RCT RCT RCT RCT Severity at enrollment (mean) PH 7.39 7.41 7.44 7.42 7.45 PaO2/FiO2 (mean, mmHg) 251 102.5 138.5 144 129 (mean, mmHg) 39 36.5 37.5 36 40 SAPS II 27.5 33.5 43.5 32 NA SOFA score NA NA NA NA NA