T reagent i: 4.12. Draw the species which is formed in the reaction of R with the base NaH. By using a curly arrow show the attack which finally leads to the formation of the bicyclus. C. Norfloxacine Norfloxacine is a synthetic antibiotic which shows a high in vitro-activity against gram-negative and gram-positive aerobic bacteria. Norfloxacine belongs to the group of the fluorquinolons. The parent compound of the quinolone-antibiotics which all have a carboxyl acid group in the is shown below. Retro consideration suggests the formation from aniline and a derivative of malonic ester. This derivate of malonic is rather unstable; the enolether of this compound (U) is used instead in the synthesis. The synthesis of Norfloxacine can be performed in a few steps according to the scheme below:
T reagent i: 4.12. Draw the species which is formed in the reaction of R with the base NaH. By using a curly arrow show the attack which finally leads to the formation of the bicyclus. C. Norfloxacine Norfloxacine is a synthetic antibiotic which shows a high in vitro-activity against gram-negative and gram-positive aerobic bacteria. Norfloxacine belongs to the group of the fluorquinolons. The parent compound of the quinolone-antibiotics which all have a carboxyl acid group in the is shown below. Retro consideration suggests the formation from aniline and a derivative of malonic ester. This derivate of malonic is rather unstable; the enolether of this compound (U) is used instead in the synthesis. The synthesis of Norfloxacine can be performed in a few steps according to the scheme below: