4. of Khambalia AZ, Australian study of archived serum 2016 Collins CE, Roberts samples of 4420 women attending CL, et al: Iron first trimester screening with birth deficiency in early and hospital data to ascertain pregnancy using maternal characteristics and serum ferritin and pregnancy outcomes. Sera were soluble transferrin analysed for iron stores (ferritin), receptor lack of iron in the tissues (sTfR); concentrations are and inflammatory (C-reactive associated with protein (CRP)) biomarkers. Total pregnancy and body iron (TBI) was calculated birth outcomes. from serum ferritin (SF) and sTfR Eur J Clin Nutr concentrations. The study 70:358-63, 2016. demonstrated the utility of sTfR along with other markers of IDA to conclude that nearly one in five Australian women begins pregnancy with IDA. 5. Study Shin DH, Kim HS, Study of the utility of sTfR and 2015 of Park MJ, et al: other markers of serum iron Utility of Access (complete blood cell count, serum Soluble Transferrin iron, total iron-binding capacity Receptor (sTfR) (TIBC), C-reactive protein (CRP), and sTfR/log ferritin, and hepcidin) in 367 Ferritin in patients with anaemia (IDA 157, Diagnosing Iron ACD 210 and 80 normal controls). Deficiency Anemia. The study concluded that while Ann Clin Lab Sci the most accurate diagnostic test 45:396-402, 2015 to differentiate IDA from ACD was SF, sTfR assay outperformed other tests in the ferritin grey zone and the sTfR/log ferritin index was the most reliable parameter in both scenarios. 6. 7. 8. 9
4. of Khambalia AZ, Collins CE, Roberts CL, et al: Iron deficiency in early pregnancy using serum ferritin and soluble transferrin receptor concentrations are associated with pregnancy and birth outcomes. Eur J Clin Nutr 70:358-63, 2016. Australian study of archived serum samples of 4420 women attending first trimester screening with birth and hospital data to ascertain maternal characteristics and pregnancy outcomes. Sera were analysed for iron stores (ferritin), lack of iron in the tissues (sTfR); and inflammatory (C-reactive protein (CRP)) biomarkers. Total body iron (TBI) was calculated from serum ferritin (SF) and sTfR concentrations. The study demonstrated the utility of sTfR along with other markers of IDA to conclude that nearly one in five Australian women begins pregnancy with IDA. 2016 5. Study of Shin DH, Kim HS, Park MJ, et al: Utility of Access Soluble Transferrin Receptor (sTfR) and sTfR/log Ferritin in Diagnosing Iron Deficiency Anemia. Ann Clin Lab Sci 45:396-402, 2015 Study of the utility of sTfR and other markers of serum iron (complete blood cell count, serum iron, total iron-binding capacity (TIBC), C-reactive protein (CRP), ferritin, and hepcidin) in 367 patients with anaemia (IDA 157, ACD 210 and 80 normal controls). The study concluded that while the most accurate diagnostic test to differentiate IDA from ACD was SF, sTfR assay outperformed other tests in the ferritin grey zone and the sTfR/log ferritin index was the most reliable parameter in both scenarios. 2015 6. 7. 8. 9