Recommended doses for repeated treatment: Clinical Pattern Units Number of (Range) injection sites Muscle per muscle Flexed Wrist 25-100 1-2 Flexor carpi radialis 20-100 1-2 Flexor carpi ulnaris Clenched Fist 40-100 2 Flexor digitorum superficialis 40-100 2 Flexor digitorum profundus Flexed Elbow 25-100 1-3 Brachioradialis 75-200 1-4 Biceps 25-100 1-2 Brachialis Pronated Forearm 10-50 1 Pronator quadratus 25-75 1-2 Pronator teres Thumb-in-Palm 10-50 1 Flexor pollicis longus 5-30 1 Adductor pollicis 5-30 1 Flexor pollicis brevis/ Opponens pollicis Maximum total recommended dose: up to 400 units per treatment session. Median time to first onset of effect: within four days after injection. Maximum effect as an improvement of muscle tone: within 4 weeks. In general, the treatment effect lasted 12 weeks. Repeat treatment should generally be no more frequent than every 12 weeks. The exact dosage and number of injection sites should be tailored to the individual patient based on size, number and localization of muscles involved, the severity of spasticity and the presence of local muscle weakness. Glabellar frown lines The optimum dose and number of injection in the treated muscle(s) should be individualised for each patient and determined by the treating doctor. Dosage Reconstitution: 50 units/1.25 mL Recommended injection volume: 0.1 mL (4 units) into each of the 5 injection sites: two injections in each corrugator muscle and one injection in the procerus muscle (Figure 4). The standard dose is 20 units. The dose may be increased by the physician to up to 30 units if required by the individual needs of the patients. Improvement in the glabellar frown lines: generally within 2 to 3 days Maximum effect: on day 30. The effect lasts up to 4 months after the injection. The intervals between treatments: 3 months. ≥
Recommended doses for repeated treatment: Clinical Pattern Muscle Units (Range) Number of injection sites per muscle Flexed Wrist Flexor carpi radialis 25-100 1-2 Flexor carpi ulnaris 20-100 1-2 Clenched Fist Flexor digitorum superficialis 40-100 2 Flexor digitorum profundus 40-100 2 Flexed Elbow Brachioradialis 25-100 1-3 Biceps 75-200 1-4 Brachialis 25-100 1-2 Pronated Forearm Pronator quadratus 10-50 1 Pronator teres 25-75 1-2 Thumb-in-Palm Flexor pollicis longus 10-50 1 Adductor pollicis 5-30 1 Flexor pollicis brevis/ Opponens pollicis 5-30 1 Maximum total recommended dose: up to 400 units per treatment session. Median time to first onset of effect: within four days after injection. Maximum effect as an improvement of muscle tone: within 4 weeks. In general, the treatment effect lasted 12 weeks. Repeat treatment should generally be no more frequent than every 12 weeks. The exact dosage and number of injection sites should be tailored to the individual patient based on size, number and localization of muscles involved, the severity of spasticity and the presence of local muscle weakness. Glabellar frown lines The optimum dose and number of injection in the treated muscle(s) should be individualised for each patient and determined by the treating doctor. Dosage Reconstitution: 50 units/1.25 mL Recommended injection volume: 0.1 mL (4 units) into each of the 5 injection sites: two injections in each corrugator muscle and one injection in the procerus muscle (Figure 4). The standard dose is 20 units. The dose may be increased by the physician to up to 30 units if required by the individual needs of the patients. Improvement in the glabellar frown lines: generally within 2 to 3 days Maximum effect: on day 30. The effect lasts up to 4 months after the injection. The intervals between treatments: ≥ 3 months.