Supplementary Figure 3 The UapA disulphide bridge a, Zoomed in region of the disulphide bond of UapA. The protein is shown from the extracellular side in ribbon representation and coloured as shown in Figure 1. Cys174 and Cys185, indicated in orange sticks, are located in the extracellular loop between TMs 3 and 4 in the core domain. The disulphide bond is shown in pale yellow. b, Alignment of UapA (AN6932) with homologues from selected representatives of major taxonomic groups. AN6730 is UapC, a paralogue of UapA in Ncra, Pchr, A. nidulans. Neurospora crassa; Penicillium Spom, Klac, Agos, chrysogenum; Schizosaccharomyces pombe; Kluyveromyces lactis; Ashbya
Supplementary Figure 3 The UapA disulphide bridge a, Zoomed in region of the disulphide bond of UapA. The protein is shown from the extracellular side in ribbon representation and coloured as shown in Figure 1. Cys174 and Cys185, indicated in orange sticks, are located in the extracellular loop between TMs 3 and 4 in the core domain. The disulphide bond is shown in pale yellow. b, Alignment of UapA (AN6932) with homologues from selected representatives of major taxonomic groups. AN6730 is UapC, a paralogue of UapA in A. nidulans. Ncra, Neurospora crassa; Pchr, Penicillium chrysogenum; Spom, Schizosaccharomyces pombe; Klac, Kluyveromyces lactis; Agos, Ashbya