comparable because RF not safe during tachycardia when substrate located near AV node. LocaLisa system used in CA and RF groups, thus improving performance c/w “conventional” RFA. CA vs. 509 CA (n=251) RFA (n=258) AVNRT Prior AVNRT Immediate N/A (AV block CA vs. RFA. N/A CA for O Study RFA for ablation CHD, prior ablation in primary AVNRT is as 2010 AVNRT pacemaker failure, endpoint) Procedure effective as (122) implantation, permanent AV duration RFA over pregnancy, and block, and (138±54 vs. short term but inability to follow AVNRT 123±48 min, associated w/ study protocol recurrence p=0.0012) higher during a 6-mo recurrence f/u Device rate at 6-mo problems: f/u. CA vs. RFA 13 vs. 2 pts, 12.6% vs. p=0.033) Risk of 6.3%, permanent AV p=0.018) Pain block does perception not differ Immediate lower in the significantly ablation cryoablation between CA success: group. and RFA. 96.8% vs. p<0.001 98.4%, p=NS Potential benefits of CA Permanent relative to AV block: ablation 0% vs. 0.4%, safety and p=NS pain perception AVNRT offset by recurrence: longer 9.4% vs. procedure
comparable because RF not safe during tachycardia when substrate located near AV node. LocaLisa system used in CA and RF groups, thus improving performance c/w “conventional” RFA. Study 2010 (122) CA vs. RFA for AVNRT 509 CA (n=251) RFA (n=258) AVNRT Prior AVNRT ablation CHD, prior pacemaker implantation, pregnancy, and inability to follow study protocol Immediate ablation failure, permanent AV block, and AVNRT recurrence during a 6-mo f/u CA vs. RFA 12.6% vs. 6.3%, p=0.018) Immediate ablation success: 96.8% vs. 98.4%, p=NS Permanent AV block: 0% vs. 0.4%, p=NS AVNRT recurrence: 9.4% vs. N/A (AV block in primary endpoint) CA vs. RFA. Procedure duration (138±54 vs. 123±48 min, p=0.0012) Device problems: 13 vs. 2 pts, p=0.033) Pain perception lower in the cryoablation group. p<0.001 N/A CA for AVNRT is as effective as RFA over short term but associated w/ higher recurrence rate at 6-mo f/u. Risk of permanent AV block does not differ significantly between CA and RFA. Potential benefits of CA relative to ablation safety and pain perception offset by longer procedure O