ASD mean 7.8 y effects of TM on and and increase in Controls mean 27.7 GSH levels free radical y generation in autism vs. control cells Brain Rose et al. [82] ASD 15 Examined cerebellum and GSH was Transl Controls 15 temporal cortex significantly Psychiatry (Brodmann area 22 decreased in both ASD 4-39 y (BA22)) the cerebellum Controls 4-36 y and BA22 in autism vs. controls; decreased GSH/GSSG capacity and increased oxidative stress in the autism brain Cerebellum and Chauhan et al. ASD 10 Compared GSH redox Levels of reduced temporal cortex [83] Controls 10 status in postmortem brain GSH were Neurochem Res samples from cerebellum significantly 4-39 y and frontal, temporal, decreased in parietal and occipital autism compared cortex of subjects with to controls: ASD vs. controls ratio of GSH to GSSG was also significantly decreased Cerebellum Gu et al. [84] ASD 10 Activities of GSH-related GPx, GST, GR, Free Radic Biol Controls 10 enzymes in the cerebellum and GCL activity Med tissues from autism and were significantly ASD mean 11.1 y controls decreased in Controls mean 11.3 autism compared y
ASD mean 7.8 y Controls mean 27.7 y effects of TM on and GSH levels and increase in free radical generation in autism vs. control cells Brain Rose et al. [82] Transl Psychiatry ASD 15 Controls 15 ASD 4-39 y Controls 4-36 y Examined cerebellum and temporal cortex (Brodmann area 22 (BA22)) GSH was significantly decreased in both the cerebellum and BA22 in autism vs. controls; decreased GSH/GSSG capacity and increased oxidative stress in the autism brain Cerebellum and temporal cortex Chauhan et al. [83] Neurochem Res ASD 10 Controls 10 4-39 y Compared GSH redox status in postmortem brain samples from cerebellum and frontal, temporal, parietal and occipital cortex of subjects with ASD vs. controls Levels of reduced GSH were significantly decreased in autism compared to controls: ratio of GSH to GSSG was also significantly decreased Cerebellum Gu et al. [84] Free Radic Biol Med ASD 10 Controls 10 ASD mean 11.1 y Controls mean 11.3 y Activities of GSH-related enzymes in the cerebellum tissues from autism and controls GPx, GST, GR, and GCL activity were significantly decreased in autism compared