19 years (n=6) since onset of work, SMR = 36.84; p<0.001) Dose response relationship observed at all durations of employment Authors conclusion: with lighter (and/or shorter) direct exposure, as time goes on, the longer the time after onset of work, the more pronounced the excesses in mortality Finkelstein & RMA ID: Radiographic 181 asbestos Chrysotile 18 year Fibre Duration of Morbidity study Asbestos Vingilis 000454 Abnormalities cement workers and cumulative concentration exposure: reporting asbestos exposure ≥1 (1984) Among (100% men) crocidolite exposures: method used: exposure producing producing small asbestos, N=181; Cumulative asbestosis and irregular 51(28%)=small silica, and n =32:0-49.9 exposures to pleural plaques opacities 1/1 or irregular Workers: an cement asbestos were more seen at opacities 1/1 or n =68: 50-99.9 Risk of small irregular factory calculated 150-199.9 more opacities category n =41: using a model fibre/mL-year >1/0 was seen at >200 40 (22%)= Study that fibre/mL-year (All men pleural n =25: extrapolated n=60; RR=2.24;Trend thickening of measurements test (X2) =27.9; category A or made by the n =15: >200 p<0.001) more personal Risk of small irregular Membrane opacities category Filter. Excluded 5 men >1/1 was seen at >200 Exposures who had died of fibre/mL-year (All men were unstated cause. n=50; RR=2.57;Trend estimated to
years (n=6) since onset of work, SMR = 36.84; p<0.001) Dose response relationship observed at all durations of employment Authors conclusion: with lighter (and/or shorter) direct exposure, as time goes on, the longer the time after onset of work, the more pronounced the excesses in mortality Finkelstein & Vingilis (1984) RMA ID: 000454 Radiographic Abnormalities Among Workers: an Study 181 asbestos cement workers (100% men) 51(28%)=small irregular opacities 1/1 or more 40 (22%)= pleural thickening of category A or more Excluded 5 men who had died of unstated cause. Chrysotile and crocidolite asbestos, silica, and cement factory 18 year cumulative exposures: N=181; n =32:0-49.9 n =68: 50-99.9 n =41: n =25: n =15: >200 Fibre concentration method used: Cumulative exposures to asbestos were calculated using a model that extrapolated measurements made by the personal Membrane Filter. Exposures were estimated to Duration of exposure: ≥1 Morbidity study reporting asbestos exposure producing asbestosis and pleural plaques Risk of small irregular opacities category >1/0 was seen at >200 fibre/mL-year (All men n=60; RR=2.24;Trend test (X2) =27.9; p<0.001) Risk of small irregular opacities category >1/1 was seen at >200 fibre/mL-year (All men n=50; RR=2.57;Trend Asbestos exposure producing small irregular opacities 1/1 or more seen at 150-199.9 fibre/mL-year 19