Serous 64 Round/oval nuclei, WT1 + hyperchromasia, large nucleoli, many mitotic figures High Grade: p53 Irregular luminal contours, focal slit-like spaces, p16 expression papillary & micropapillary Loss of expression BRCA1 architecture Low Low Serous Borderline mutation BRAF/KRAS Tumour associated Endometrioid 17 Endometrial-like, metaplasias, ER/PR + secretory change, expansile Nuclear + β-catenin invasion WT1 - β-catenin/PTEN/PIK3 mutation Endometriosis/Endometrioid Borderline Tumour/ Endometrioid Uterine Microsatellite Carcinoma associated (MSI-H) Mucinous 13 Intracytoplasmic mucin, CK7 >20 expansile invasion Retained SMAD4 expression Intestinal Mucinous Borderline Nuclear - β-catenin Tumour associated ER - p16 - Mesothelin - Fascin - Racemase - mutation KRAS Clear Cell 6 Papillary, tubulocystic, ER/PR – hobnail, frequently clear WT1 – cytoplasm; Glycogen-filled p53 – vaginal rests mib-1 - MSI-H/PTEN mutation Endometriosis/Clear Cell Borderline Tumour associated Table 1.4. Histological features of EOC sub-types (adapted from []).
Serous 64 Round/oval nuclei, hyperchromasia, large nucleoli, many mitotic figures Irregular luminal contours, focal slit-like spaces, papillary & micropapillary architecture Low Serous Borderline Tumour associated WT1 + High Grade: p53 p16 expression Loss of BRCA1 expression Low BRAF/KRAS mutation Endometrioid 17 Endometrial-like, metaplasias, secretory change, expansile invasion Endometriosis/Endometrioid Borderline Tumour/ Endometrioid Uterine Carcinoma associated ER/PR + Nuclear β-catenin + WT1 - β-catenin/PTEN/PIK3 mutation Microsatellite (MSI-H) Mucinous 13 Intracytoplasmic mucin, expansile invasion Intestinal Mucinous Borderline Tumour associated CK7 >20 Retained SMAD4 expression Nuclear β-catenin - ER - p16 - Mesothelin - Fascin - Racemase - KRAS mutation Clear Cell 6 Papillary, tubulocystic, hobnail, frequently clear cytoplasm; Glycogen-filled vaginal rests Endometriosis/Clear Cell Borderline Tumour associated ER/PR – WT1 – p53 – mib-1 - MSI-H/PTEN mutation Table 1.4. Histological features of EOC sub-types (adapted from []).