Prognosis mostly depends on histology: – (potentially curable) > (excellent prognosis; > 90% 5-yr survival; 85% mature teratomas germinomas 10-year survival following craniospinal irradiation alone) > nongerminomatous germ (patients rarely survive beyond 2 years) cell tumors local recurrence and CSF-borne dissemination are usual patterns of disease progression. Metastases within CNS and vertebral column are most common causes of death! ICH is most common cause of death in choriocarcinoma! Can recur locally / distally as late as 5 yrs after diagnosis! regular follow-up: – MRI marker* follow-up: q 1-2 months for 1 year q 3 months for 1 year less → → frequently. *even if markers were not abnormal at diagnosis Bibliography for ch. follow this “Neuro-Oncology” →
Prognosis – mostly depends on histology: mature teratomas (potentially curable) > germinomas (excellent prognosis; > 90% 5-yr survival; 85% 10-year survival following craniospinal irradiation alone) > nongerminomatous germ cell tumors (patients rarely survive beyond 2 years) local recurrence and CSF-borne dissemination are usual patterns of disease progression. Metastases within CNS and vertebral column are most common causes of death! ICH is most common cause of death in choriocarcinoma! Can recur locally / distally as late as 5 yrs after diagnosis! – regular follow-up: MRI marker* follow-up: q 1-2 months for 1 year → q 3 months for 1 year → less frequently. *even if markers were not abnormal at diagnosis Bibliography for ch. “Neuro-Oncology” → follow this