Table 4. Summary of acute toxicity data Skin Acute Toxicity Irritation Sensitisation Oral LD50 Dermal LD50 Backbone C Inhalation LC50 Phthalate Skin Eye Respiratory Length (mg/L) (mg/kg bw) (mg/kg bw) Rat: Rat: C1 DMP ME ME negative 2860 10000 38000 – Rat: Rat: Rat: C2 DEP ME ME negative >5600 31000 >11000 7.50 – C3 Rat: Rabbit: Rat, 1h: Positive DAP negative negative (double bond) 656 891 3300 5.20 10.31 (LLNA) – – Rat: Guinea pig: Rat, 6h: C3 DMEP ME ME negative 3200 6400 >1171 >770-1595 ppm – Rat: C3 DIBP ME negative negative 16000 60320 – Rat: Rabbit: Rat, 4h: C4 DBP ME ME ME negative 6300 8000 >20000 15.68 – ≥ Rat: Rat: C4, C5 BBP ME ME negative 2330 20400 6700 – C4 Rat: Rabbit: Rat: insufficient DCHP ME ME (ring) >3200 >300 >3.20 data C5 DIHP negative negative Rabbit: Rat: C6 DnHP ME 29600 >20 (mL/kg bw) Rat: Rabbit: C6-rich DiHepP ME ME negative >10000 >3160 Rat: Rat: Rabbit: insufficient C6 DEHP ME ME negative 30600 >40000 24750 data >10.62 – Rat: Rabbit: C7 DIOP ME negative >22000 >3160
Table 4. Summary of acute toxicity data Acute Toxicity Irritation Skin Sensitisation Backbone C Length Phthalate Oral LD50 (mg/kg bw) Dermal LD50 (mg/kg bw) Inhalation LC50 (mg/L) Skin Eye Respiratory C1 DMP Rat: 2860 – 10000 Rat: 38000 ME ME negative C2 DEP Rat: >5600 – 31000 Rat: >11000 Rat: 7.50 ME ME negative C3 (double bond) DAP Rat: 656 – 891 Rabbit: 3300 Rat, 1h: 5.20 – 10.31 negative negative Positive (LLNA) C3 DMEP Rat: 3200 – 6400 Guinea pig: >1171 Rat, 6h: >770-1595 ppm ME ME negative C3 DIBP Rat: 16000 – 60320 ME negative negative C4 DBP Rat: 6300 – 8000 Rabbit: >20000 Rat, 4h: ≥ 15.68 ME ME ME negative C4, C5 BBP Rat: 2330 – 20400 Rat: 6700 ME ME negative C4 (ring) DCHP Rat: >3200 Rabbit: >300 Rat: >3.20 ME ME insufficient data C5 DIHP negative negative C6 DnHP Rat: 29600 Rabbit: >20 (mL/kg bw) ME C6-rich DiHepP Rat: >10000 Rabbit: >3160 ME ME negative C6 DEHP Rat: 30600 – >40000 Rabbit: 24750 Rat: >10.62 ME ME insufficient data negative C7 DIOP Rat: >22000 Rabbit: >3160 ME negative