Appendix 7. Example of Bias Assessment for Sodium Alternative Reported to Name (NA) (# DP) 0 Serum/ plasma Units mmol/L Sample type Direct and Indi- rect ISE Paediatric See below for details inter- Methods Yes vals: Pregnancy inter- LOINC No vals: Reference interval survey data: 132 - 145 mmol/L Manufacturers 145 intervals: Dimension 136 145 Vitros 137 145 Advia 136 146 Modular 133 145 AU 136 146 Integra 136 145 DxC/Dxi 136 144 cobas 6000 136 145 Architect 136 145 cobas 8000 136 Manufactures Reference method Reference method traceable to: Dimension NIST Vitros SRM (RXL/EXL) Flame Flame atomic NIST 2201 Atomic emission SRM Absorption spectoscopy 919a Photometry NIST Flame photom- Dimension STM etry (Vista) Modular NIST 909 Flamephotometry 9096 Advia Integra NIST 909 CDC Flame SRM Photometry Flamephotometry 909b reference Method SRM 956a AU cobas 6000 NIST 909 Flamephotometry SRM 919a DxC/Dxi cobas 8000 NIST 909 Flamephotometry Architect NIST Flamephotometry 909 Analytical platforms assessed in Bias survey: Advia 2400, Architect, AU2700, DxC, Integra, Modular, RxL, Vitros No sign. method bias Bias assessment outcome:
Appendix 7. Example of Bias Assessment for Sodium Alternative Name (NA) Reported to (# DP) 0 Units mmol/L Sample type Serum/ plasma Methods Direct and Indi- rect ISE Paediatric inter- vals: Yes See below for details LOINC Pregnancy inter- vals: No Reference interval survey data: 132 - 145 mmol/L Manufacturers intervals: Dimension 136 145 Vitros 137 145 Advia 136 146 Modular 133 145 AU 136 146 Integra 136 145 DxC/Dxi 136 144 cobas 6000 136 145 Architect 136 145 cobas 8000 136 145 Manufactures traceable to: Reference method Reference method Dimension (RXL/EXL) NIST SRM 2201 Flame Atomic Absorption Photometry Vitros NIST SRM 919a Flame atomic emission spectoscopy Dimension (Vista) NIST STM 9096 Flame photom- etry Modular NIST 909 Flamephotometry Advia SRM 909b CDC Flame Photometry reference Method Integra NIST 909 Flamephotometry AU SRM 956a cobas 6000 NIST 909 Flamephotometry DxC/Dxi SRM 919a cobas 8000 NIST 909 Flamephotometry Architect NIST 909 Flamephotometry Analytical platforms assessed in Bias survey: Advia 2400, Architect, AU2700, DxC, Integra, Modular, RxL, Vitros Bias assessment outcome: No sign. method bias