Inhalation: whole body exposure for 4 hours. Method of administration: Number of Nominal Achieved Mortality animals/sex concentration concentration % v/v % v/v (mg/L) I 5/sex 0 0 0 II 5/sex 15 14.3 0 (790) III 5/sex 20 20.3 0 (1110) OECD TG 403 Test method: During exposure exaggerated respiratory movements, Clinical observations: abnormal body posture and reduced response to external stimuli were noted in all treated animals at both exposure concentrations. Occasional clonic convulsions were also seen in three low concentration females. Rats recovered from effects within 10 minutes of exposure cessation and remained normal throughout the observation period. No macroscopic findings were observed. Morphological findings: >1110 mg/L/4-hour LC50: The notified chemical was of very low acute inhalation Result: toxicity in rats. 9.1.4 Inhalation Toxicity in Mice (Pharmaco LSR Ltd, 1994a) Mouse / CD-1 Species/strain: 14 days Observation period: Inhalation: snout only exposure for 4 hours. Method of administration: Number of Nominal concentration Achieved Mortality animals/sex concentration ppm mg/L ppm mg/L I 5/sex 0 0 0 II 5/sex 100 000 548 101 300 555 0 OECD TG 403 Test method: Treated animals were observed to be less active than Clinical observations: controls from 30 minutes into the exposure period. All
Method of administration: Inhalation: whole body exposure for 4 hours. Number of animals/sex Nominal concentration % v/v Achieved concentration % v/v (mg/L) Mortality I 5/sex 0 0 0 II 5/sex 15 14.3 (790) 0 III 5/sex 20 20.3 (1110) 0 Test method: OECD TG 403 Clinical observations: During exposure exaggerated respiratory movements, abnormal body posture and reduced response to external stimuli were noted in all treated animals at both exposure concentrations. Occasional clonic convulsions were also seen in three low concentration females. Rats recovered from effects within 10 minutes of exposure cessation and remained normal throughout the observation period. Morphological findings: No macroscopic findings were observed. LC50: >1110 mg/L/4-hour Result: The notified chemical was of very low acute inhalation toxicity in rats. 9.1.4 Inhalation Toxicity in Mice (Pharmaco LSR Ltd, 1994a) Species/strain: Mouse / CD-1 Observation period: 14 days Method of administration: Inhalation: snout only exposure for 4 hours. Number of animals/sex Nominal concentration Achieved concentration Mortality ppm mg/L ppm mg/L I 5/sex 0 0 0 II 5/sex 100 000 548 101 300 555 0 Test method: OECD TG 403 Clinical observations: Treated animals were observed to be less active than controls from 30 minutes into the exposure period. All