antibodies on hyperacute rejection episodes? What complications can some Antibody-mediated rejection may take place over individuals who possess very low levels several days. of antibody in the period encounter? What has the antibody-mediated Accelerated rejection. rejection that may take place over several days termed? What do hyperacute rejection and They both involve intravascular thrombosis and accelerated rejection have in common? necrosis of donor tissue. How long does acute cellular rejection Days to after transplant. take to develop? Though acute cellular rejection is a Antibodies. cellular-type rejection, what other immunologic participant is also involved? What is characteristic of acute rejection? Parenchymal and vascular injury. What types of immunological cells are CD8+ T cells, CD4 T cells, and macrophages. predominately are found in interstitial cellular infiltrates? What roles do CD8+ and CD4 T cells CD8+=Mediate cytotoxic reactions to foreign play in interstitial cellular infiltrates? expressing cells CD4= Produce cytokines and induce delayed-type hypersensitivity (DTH) reactions. What role do antibodies play in graft Antibodies bind to vessel activate complement, rejection? and induce transmural necrosis and inflammation. Do antibodies in hyperacute rejection No. and graft rejection play the same Hyperacute rejection= create a thrombosis. role? Acute graft rejection= bind to vessel walls, activate complement, and induce transmural necrosis and inflammation How has the development and The response to alloantigens has improved early graft application of potent immunosuppressive survival by reducing the incidence of acute rejection drugs that target multiple pathways in the and providing approaches for its effective treatment. immune response affected solid-organ transplants? What remains the most significant cause Chronic rejection. of graft loss after the first year Why is chronic rejection a significant It is not readily amendable to treatment. cause of graft loss? What is characteristic of chronic It is a process of graft arteriosclerosis characterized rejection? by progressive fibrosis, and scarring with narrowing of the vessel lumen due to proliferation of smooth muscle cells.
antibodies on hyperacute rejection episodes? What complications can some individuals who possess very low levels of antibody in the period encounter? Antibody-mediated rejection may take place over several days. What has the antibody-mediated rejection that may take place over several days termed? Accelerated rejection. What do hyperacute rejection and accelerated rejection have in common? They both involve intravascular thrombosis and necrosis of donor tissue. How long does acute cellular rejection take to develop? Days to after transplant. Though acute cellular rejection is a cellular-type rejection, what other immunologic participant is also involved? Antibodies. What is characteristic of acute rejection? Parenchymal and vascular injury. What types of immunological cells are predominately are found in interstitial cellular infiltrates? CD8+ T cells, CD4 T cells, and macrophages. What roles do CD8+ and CD4 T cells play in interstitial cellular infiltrates? CD8+=Mediate cytotoxic reactions to foreign cells CD4= Produce cytokines and induce delayed-type hypersensitivity (DTH) reactions. What role do antibodies play in graft rejection? Antibodies bind to vessel activate complement, and induce transmural necrosis and inflammation. Do antibodies in hyperacute rejection and graft rejection play the same role? No. Hyperacute rejection= create a thrombosis. Acute graft rejection= bind to vessel walls, activate complement, and induce transmural necrosis and inflammation How has the development and application of potent immunosuppressive drugs that target multiple pathways in the immune response affected solid-organ transplants? The response to alloantigens has improved early graft survival by reducing the incidence of acute rejection and providing approaches for its effective treatment. What remains the most significant cause of graft loss after the first year Chronic rejection. Why is chronic rejection a significant cause of graft loss? It is not readily amendable to treatment. What is characteristic of chronic rejection? It is a process of graft arteriosclerosis characterized by progressive fibrosis, and scarring with narrowing of the vessel lumen due to proliferation of smooth muscle cells. expressing