Time after treatment Exposure time 1 hour 24 hours 48 72 hours Erythema 3 minutes 1a nd nd nd 1 hour 2 nd nd nd 4 hours 2 3p 4pg 4g Oedema 3 minutes 1 nd nd nd 1 hour 2 nd nd nd 4 2 3 3 3 a see Attachment 1 for Draize scales p pale areas g gray areas nd not determined Body weight changes were normal and no abnormal Comment: systemic signs were noted during the observation period. The notified chemical was corrosive to the skin of rabbits. Result: 9.1.5 Eye Irritation (Cerven, 2000) Rabbit, New Zealand White Species/strain: 1 male Number/sex of animals: 48 Observation period: 0.1 mL of test substance instilled into the conjunctival sac of Method of administration: one eye; the contralateral eye served as an untreated control. OECD TG 405 Test method: Draize scores of unirrigated eyes: Time instillation Animal 1 hour 24 hours 48 hours Cornea o a o a o a 21 1 3 1 nd nd Iris 0 1 nd Conjunctiva r c d r c d r c d
Time after treatment Exposure time 1 hour 24 hours 48 72 hours Erythema 3 minutes 1a nd nd nd 1 hour 2 nd nd nd 4 hours 2 3p 4pg 4g Oedema 3 minutes 1 nd nd nd 1 hour 2 nd nd nd 4 2 3 3 3 a see Attachment 1 for Draize scales p pale areas g gray areas nd not determined Comment: Body weight changes were normal and no abnormal systemic signs were noted during the observation period. Result: The notified chemical was corrosive to the skin of rabbits. 9.1.5 Eye Irritation (Cerven, 2000) Species/strain: Rabbit, New Zealand White Number/sex of animals: 1 male Observation period: 48 Method of administration: 0.1 mL of test substance instilled into the conjunctival sac of one eye; the contralateral eye served as an untreated control. Test method: OECD TG 405 Draize scores of unirrigated eyes: Time instillation Animal 1 hour 24 hours 48 hours Cornea o a o a o a 21 1 3 1 nd nd Iris 0 1 nd Conjunctiva r c d r c d r c d