EMA Duloxetine 60-120 Yes 6 T6 514 69.6 47.6± 13.3 No 27 16 Yes Duloxetine study 2008 EMA Sertraline Sertraline 119.8 Yes 10 T10 43 67.4 70.4 No 4 11 Yes study 1994 Placebo 42 52.4 78.5 7 6 (Protocol N. 86CE21-0247) EMA Sertraline Sertraline 145 Yes 8 T8 149 - - No 26 29 Yes study 1994 Placebo 150 - - 16 18 (Protocol N. 050-104) EMA Sertraline Sertraline 50 Yes 8 T8 40 70 37.5 No 12 5 Yes study 1991 Sertraline 100 39 79.5 38.6 12 5 (Protocol N. 86CE21-0238) Sertraline 200 43 62.8 37.3 20 7 Sertraline 400 37 67.6 37.3 12 5 Placebo 40 70 37.3 9 5 EMA Venlafaxine 22 Yes 6+52 T6 79 69.6 38.9 No Yes Venlafaxine Venlafaxine 52.4 76 69.7 38.0 study 1990 (Protocol N. Venlafaxine 139.5 79 60.8 38.8 600-A-313-US) Placebo 78 69.2 38.2 EMA Venlafaxine 185.1 Yes 6+52 T6 70 70 40 No 7 31 Yes Venlafaxine Placebo 79 68.3 39 3 9 study 1990 EMA Venlafaxine 160 Yes 6+52 T6 65 60 42.3 No 13 28 Yes Venlafaxine Placebo 75 66.7 41.3 6 11 study 1990 (Protocol N. 600A-302-US)
EMA Duloxetine study 2008 Duloxetine 60-120 Yes 6 T6 514 69.6 47.6± 13.3 No 27 16 Yes EMA Sertraline study 1994 (Protocol N. 86CE21-0247) Sertraline Placebo 119.8 Yes 10 T10 43 42 67.4 52.4 70.4 78.5 No 4 7 11 6 Yes EMA Sertraline study 1994 (Protocol N. 050-104) Sertraline Placebo 145 Yes 8 T8 149 150 - - - - No 26 16 29 18 Yes EMA Sertraline study 1991 (Protocol N. 86CE21-0238) Sertraline Sertraline Sertraline Sertraline Placebo 50 100 200 400 Yes 8 T8 40 39 43 37 40 70 79.5 62.8 67.6 70 37.5 38.6 37.3 37.3 37.3 No 12 12 20 12 9 5 5 7 5 5 Yes EMA Venlafaxine study 1990 (Protocol N. 600-A-313-US) Venlafaxine Venlafaxine Venlafaxine Placebo 22 52.4 139.5 Yes 6+52 T6 79 76 79 78 69.6 69.7 60.8 69.2 38.9 38.0 38.8 38.2 No Yes EMA Venlafaxine study 1990 Venlafaxine Placebo 185.1 Yes 6+52 T6 70 79 70 68.3 40 39 No 7 3 31 9 Yes EMA Venlafaxine study 1990 (Protocol N. 600A-302-US) Venlafaxine Placebo 160 Yes 6+52 T6 65 75 60 66.7 42.3 41.3 No 13 6 28 11 Yes