n=14 women (28%) Previous PCI: 8% CAD risk factors: hypertension 52% hyperlipidaemia 58% smoker 42% diabetes 46% Klein et al. () Level IV N=55 consecutive patients with suspected Exclusion criteria: Adenosine SP-CMR + LGE CAD who were referred for ICA Germany A case series with either Known MI; atrial fibrillation; unstable angina; AV block >1st-degree; post-test or Mean age: 60 ± 10 years obstructive lung disease; claustrophobia or other contraindications outcomes n=19/54 women (35%) for CMR Mean LVEF: 59 ± 9% Low risk of bias (IHE 8/12) CAD risk factors: hypertension 69% hypercholesterolaemia 76% smoker 33% diabetes 22% family history 31% Klem et al. () Level IV N=100 consecutive women with chest Inclusion criteria: Adenosine SP-CMR + LGE pain or other symptoms suggestive of USA and A case series with either Women who referred to the Duke University Medical Center in CAD who were not included in the Klem et Germany post-test or Durham NC, USA, and to Robert-Bosch-Krankenhaus Hospital in al. (2006) study outcomes Stuttgart, Germany Mean age: 63 ± 11.1 years Low risk of bias Exclusion criteria: (IHE 9/12) Angina according to Rose chest pain Patients with known CAD including those with prior MI or questionnaire: 50% revascularisation procedures; and contraindications to CMR (e.g. CAD risk factors: pacemaker) or adenosine (e.g. high-grade AV-block) hypertension 68% hyperlipidaemia 57% smoker 31% diabetes 22%
n=14 women (28%) Previous PCI: 8% CAD risk factors: hypertension 52% hyperlipidaemia 58% smoker 42% diabetes 46% Klein et al. () Germany Level IV A case series with either post-test or outcomes Low risk of bias (IHE 8/12) N=55 consecutive patients with suspected CAD who were referred for ICA Mean age: 60 ± 10 years n=19/54 women (35%) Mean LVEF: 59 ± 9% CAD risk factors: hypertension 69% hypercholesterolaemia 76% smoker 33% diabetes 22% family history 31% Exclusion criteria: Known MI; atrial fibrillation; unstable angina; AV block >1st-degree; obstructive lung disease; claustrophobia or other contraindications for CMR Adenosine SP-CMR + LGE Klem et al. () USA and Germany Level IV A case series with either post-test or outcomes Low risk of bias (IHE 9/12) N=100 consecutive women with chest pain or other symptoms suggestive of CAD who were not included in the Klem et al. (2006) study Mean age: 63 ± 11.1 years Angina according to Rose chest pain questionnaire: 50% CAD risk factors: hypertension 68% hyperlipidaemia 57% smoker 31% diabetes 22% Inclusion criteria: Women who referred to the Duke University Medical Center in Durham NC, USA, and to Robert-Bosch-Krankenhaus Hospital in Stuttgart, Germany Exclusion criteria: Patients with known CAD including those with prior MI or revascularisation procedures; and contraindications to CMR (e.g. pacemaker) or adenosine (e.g. high-grade AV-block) Adenosine SP-CMR + LGE