(Guelfi et al. Fluoxetine 20 Yes 12 T12 100 75 5.8± 12.8 No 10 - Yes 1998)() Milnacipran 100 93 60 45.6±12.4 4 - Milnacipran 200 96 66 45.2± 12.5 4 - (Guelfi et al. Mirtazapine 49.5 ± 8.3 Yes 8 T8 78 62.8 45.9±10.4 No - 6 Yes 2001)() Venlafaxine 255.0±59.8 79 68.4 44.5± 10.8 - 4 (Hale et al. Agomelatine 25-50 No 8 T8 250 77 41.8± 11.2 No - 15 Yes 2010)() Fluoxetine 20-40 263 78.3 42.7±11.9 - 9 (Halikas et al. Mirtazapine 20.1 No 6 T6 49 42.9 63 No - 26 Yes 1995)() Placebo 49 59.2 62 - 11 (Hewett et al. Bupropion XR 180 No 8 T8 203 63 45.6± 11.8 No 15 3 Yes (I) 2010)() Venlafaxine XR 85 198 68 44.1±11.5 13 9 Placebo 187 67 44.5±10.8 8 9 (Hewett et al. Bupropion XR 179 No 10 T10 211 74 70.9±5.6 No 13 - Yes (II) 2010)() Placebo 207 70 71.3±5.9 8 - (Higuchi et al. Paroxetine CR 25-50 No 8 T8 161 53 36.4± 11.5 No - 16 Yes 2011)() Paroxetine IR 20-40 83 58 35.5± 10.4 - 7 Placebo 172 55 36.8± 10.1 - 3 (Hong et al. Fluoxetine 30.7 Yes 6 T6 66 63.6 47.1± 15.5 No - 3 Yes 2003)() Mirtazapine 34.1 66 62.1 47.2± 14.7 - 8 (Høyberg et al. Mirtazapine 37.3 Yes 6 T6 56 78.6 70.5 No - 3 Yes 1996) ()
(Guelfi et al. 1998)() Fluoxetine Milnacipran Milnacipran 20 100 200 Yes 12 T12 100 93 96 75 60 66 5.8± 12.8 45.6±12.4 45.2± 12.5 No 10 4 4 - - - Yes (Guelfi et al. 2001)() Mirtazapine Venlafaxine 49.5 ± 8.3 255.0±59.8 Yes 8 T8 78 79 62.8 68.4 45.9±10.4 44.5± 10.8 No - - 6 4 Yes (Hale et al. 2010)() Agomelatine Fluoxetine 25-50 20-40 No 8 T8 250 263 77 78.3 41.8± 11.2 42.7±11.9 No - - 15 9 Yes (Halikas et al. 1995)() Mirtazapine Placebo 20.1 No 6 T6 49 49 42.9 59.2 63 62 No - - 26 11 Yes (Hewett et al. (I) 2010)() Bupropion XR Venlafaxine XR Placebo 180 85 No 8 T8 203 198 187 63 68 67 45.6± 11.8 44.1±11.5 44.5±10.8 No 15 13 8 3 9 9 Yes (Hewett et al. (II) 2010)() Bupropion XR Placebo 179 No 10 T10 211 207 74 70 70.9±5.6 71.3±5.9 No 13 8 - - Yes (Higuchi et al. 2011)() Paroxetine CR Paroxetine IR Placebo 25-50 20-40 No 8 T8 161 83 172 53 58 55 36.4± 11.5 35.5± 10.4 36.8± 10.1 No - - - 16 7 3 Yes (Hong et al. 2003)() Fluoxetine Mirtazapine 30.7 34.1 Yes 6 T6 66 66 63.6 62.1 47.1± 15.5 47.2± 14.7 No - - 3 8 Yes (Høyberg et al. 1996) () Mirtazapine 37.3 Yes 6 T6 56 78.6 70.5 No - 3 Yes