TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 3 4. PHYSICAL AND CHEMICAL PROPERTIES 3 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure assessment 5 6.1.1 Occupational exposure 5 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 7 6.3.1. Occupational health and safety 7 6.3.2. Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3. Environmental risk assessment 10 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 10 Hazard classification 10 Human health risk assessment 10 Environmental risk assessment 11 Recommendations 11 Regulatory Obligations 11 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity oral 15 – B.2. Acute toxicity inhalation 15 – B.3. Irritation skin 16 – B.4. Irritation eye 16 – B.5. Skin sensitisation mouse local lymph node assay (LLNA) 17 – B.6. Repeat dose toxicity 18 B.7. Genotoxicity bacteria 19 – B.8. Genotoxicity in vitro 20 – Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. biodegradability 21 C.1.2. Bioaccumulation 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 23 C.2.4. Inhibition of microbial activity 23 Bibliography 25
TABLE OF CONTENTS Full Public Report 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 3 4. PHYSICAL AND CHEMICAL PROPERTIES 3 5. INTRODUCTION AND USE INFORMATION 4 6. HUMAN HEALTH IMPLICATIONS 5 6.1 Exposure assessment 5 6.1.1 Occupational exposure 5 6.1.2. Public exposure 6 6.2. Human health effects assessment 6 6.3. Human health risk characterisation 7 6.3.1. Occupational health and safety 7 6.3.2. Public health 8 7. ENVIRONMENTAL IMPLICATIONS 8 7.1. Environmental Exposure & Fate Assessment 8 7.1.1 Environmental Exposure 8 7.1.2 Environmental fate 9 7.1.3 Predicted Environmental Concentration (PEC) 9 7.2. Environmental effects assessment 10 7.2.1 Predicted No-Effect Concentration 10 7.3. Environmental risk assessment 10 8. CONCLUSIONS AND REGULATORY OBLIGATIONS 10 Hazard classification 10 Human health risk assessment 10 Environmental risk assessment 11 Recommendations 11 Regulatory Obligations 11 Appendix A: Physical and Chemical Properties 13 Appendix B: Toxicological Investigations 15 B.1. Acute toxicity – oral 15 B.2. Acute toxicity – inhalation 15 B.3. Irritation – skin 16 B.4. Irritation – eye 16 B.5. Skin sensitisation – mouse local lymph node assay (LLNA) 17 B.6. Repeat dose toxicity 18 B.7. Genotoxicity – bacteria 19 B.8. Genotoxicity – in vitro 20 Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. biodegradability 21 C.1.2. Bioaccumulation 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 23 C.2.4. Inhibition of microbial activity 23 Bibliography 25