Table S1 MITOCHONDRIAL DYSFUNCTION Azathioprine Taxol Aconitase 2, mitochondrial ACO2 ↑ 1.41 ↓ 1.23 Apoptosis-inducing factor, mitochondrion-associated 1 AIFM1 ↑ 1.74 Amyloid beta (A4) precursor protein APP ↑ 2.57 ATP5A1 ↓ 1.51 ↓ 1.16 ATP5B ↑ 2.36 ATP synthase, mitochondrial ATP5F1 ↓ 1.70 ↓ 1.51 ATP5H ↑ 1.56 ATP5J ↑ 1.36 COX17 cytochrome c oxidase copper chaperone COX17 ↓ 2.00 COX5A ↓ 1.39 COX5B ↑ 1.37 Cytochrome c oxidase COX6A1 ↑ 1.47 COX6C ↓ 1.62 Cytochrome b5 reductase 3 CYB5R3 ↑ 1.52 ↑ 1.36 Cytochrome c CYCS ↓ 1.61 Glycerol-3-phosphate dehydrogenase 2, mitochondrial GPD2 ↓ 1.51 ↓ 1.33 Hydroxysteroid (17-beta) dehydrogenase, mitochondrial HSD17B10 ↓ 1.62 NDUFB10 ↓ 1.29 NDUFS1 ↓ 1.73 NADH dehydrogenase (ubiquinone) NDUFS7 ↓ 1.31 NDUFV1 ↑ 1.54 NDUFV2 ↓ 1.45 2-oxoglutarate dehydrogenase OGDH ↓ 1.37 Parkinson protein 7 PARK7 ↑ 1.80 Peroxiredoxin 5 PRDX5 ↑ 1.33 SDHA ↓ 2.43 Succinate dehydrogenase complex SDHB ↓ 1.51 Superoxide dismutase 2, mitochondrial SOD2 ↑ 1.69 ↓ 1.87 UQCRB ↑ 1.62 Ubiquinol-cytochrome c reductase UQCRC1 ↓ 1.42 VDAC1 ↑ 1.54 Voltage-dependent anion VDAC2 ↑ 1.32
Table S1 MITOCHONDRIAL DYSFUNCTION Azathioprine Taxol Aconitase 2, mitochondrial ACO2 ↑ 1.41 ↓ 1.23 Apoptosis-inducing factor, mitochondrion-associated 1 AIFM1 ↑ 1.74 Amyloid beta (A4) precursor protein APP ↑ 2.57 ATP synthase, mitochondrial ATP5A1 ↓ 1.51 ↓ 1.16 ATP5B ↑ 2.36 ATP5F1 ↓ 1.70 ↓ 1.51 ATP5H ↑ 1.56 ATP5J ↑ 1.36 COX17 cytochrome c oxidase copper chaperone COX17 ↓ 2.00 Cytochrome c oxidase COX5A ↓ 1.39 COX5B ↑ 1.37 COX6A1 ↑ 1.47 COX6C ↓ 1.62 Cytochrome b5 reductase 3 CYB5R3 ↑ 1.52 ↑ 1.36 Cytochrome c CYCS ↓ 1.61 Glycerol-3-phosphate dehydrogenase 2, mitochondrial GPD2 ↓ 1.51 ↓ 1.33 Hydroxysteroid (17-beta) dehydrogenase, mitochondrial HSD17B10 ↓ 1.62 NADH dehydrogenase (ubiquinone) NDUFB10 ↓ 1.29 NDUFS1 ↓ 1.73 NDUFS7 ↓ 1.31 NDUFV1 ↑ 1.54 NDUFV2 ↓ 1.45 2-oxoglutarate dehydrogenase OGDH ↓ 1.37 Parkinson protein 7 PARK7 ↑ 1.80 Peroxiredoxin 5 PRDX5 ↑ 1.33 Succinate dehydrogenase complex SDHA ↓ 2.43 SDHB ↓ 1.51 Superoxide dismutase 2, mitochondrial SOD2 ↑ 1.69 ↓ 1.87 Ubiquinol-cytochrome c reductase UQCRB ↑ 1.62 UQCRC1 ↓ 1.42 Voltage-dependent anion VDAC1 ↑ 1.54 VDAC2 ↑ 1.32