McKeigue ADDIN 89 EN.CITE (discordance in statistical Genetic risk score of 6 >0.05 NA 2010 Scottish 1,017/203 Metabolic syndrome NA NA significance) SNPs in SCL2A9 Kidney disorders Yang ADDIN EN.CITE 23,387/3,092 Genetic risk score of 8 1.20 (0.96, 1.50) 0.12 2010 American CKD 6.0% OR (5)* SUA-related SNPs Greenberg ADDIN EN.CITE Genetic risk score of 8 1.01 (0.77, 1.34) 0.92 2015 USA 7,553/823 Acute kidney injury 6.0% HR SUA-related SNPs Testa ADDIN EN.CITE 2.35 (1.25, 4.42) 0.01 2014 Italy 755/244 Renal events rs734553 in GLUT9 NA HR Hughes ADDIN NO ADDIN EN.CITE EN.CITE European eGFR (mL/min/1.73 Genetic risk score of 5 0.31 β 2013 7,979 (2)* 2.3% 12.20 (-11.50, 35.90) Caucasian m2) SUA-related SNPs 72 79 92
89 (discordance in statistical significance) McKeigue ADDIN EN.CITE 2010 Scottish 1,017/203 Metabolic syndrome Genetic risk score of 6 SNPs in SCL2A9 NA NA NA >0.05 Kidney disorders Yang ADDIN EN.CITE 2010 American 23,387/3,092 (5)* CKD Genetic risk score of 8 SUA-related SNPs 6.0% OR 1.20 (0.96, 1.50) 0.12 Greenberg ADDIN EN.CITE 2015 USA 7,553/823 Acute kidney injury Genetic risk score of 8 SUA-related SNPs 6.0% HR 1.01 (0.77, 1.34) 0.92 Testa ADDIN EN.CITE 2014 Italy 755/244 Renal events rs734553 in GLUT9 NA HR 2.35 (1.25, 4.42) 0.01 Hughes ADDIN EN.CITE 2013 European Caucasian 7,979 (2)* eGFR (mL/min/1.73 m2) Genetic risk score of 5 SUA-related SNPs 2.3% β 12.20 (-11.50, 35.90) 0.31 NO ADDIN EN.CITE 72 79 92