(Detke et al. Duloxetine 80 Yes 8 T8 95 73.7 43.1 ±11.1 No 5 2 Yes 2004)() Duloxetine 120 93 75.3 44.7±10.7 5 7 Paroxetine 20 86 67.4 42.0±10.6 3 5 Placebo 93 74.2 43.7±12.2 7 0 (Diaz-Martinez Fluoxetine 20-40 Yes 8 T8 75 78.6 37 No 18 15 Yes et al. 1998)() Venlafaxine 75-150 70 64.3 37 22 15 (Dierick et al. Fluoxetine 20 Yes 8 T8 161 65.2 43.2± 13.0 No 13 - Yes 1996)() Venlafaxine 75-112 153 65.4 43.7± 12.5 11 - (Doogan et al. Sertraline 50 Yes 6 T6 83 71.1 46.0 No - 2 No 1994)() Placebo 90 64.4 45.4 - 0 (Dubè et al. Escitalopram 15.2 Yes 8 T8 62 35.5 34.3±9.7 No 2 15 Yes 2010)() Placebo 138 47.1 37.5±11.0 4 11 (Dunbar et al. Paroxetine 10-50 No 6 T6 240 46.7 40.3 No - 27 Yes 1991)() Placebo 240 44.2 40.3 - 11 (Dunner et al. Paroxetine 23.4 Yes 6 T6 136 73 68 No No 1992)() (Dunner et al. Duloxetine 30-120 No 12 T12 67 56.7 42.3± 13.5 No 12 8 Yes 2005)() Duloxetine 30-120 70 62.9 42.0± 12.6 12 9 (Eker et al. Reboxetine 14.4 No 10 T10 20 75 41.3 ± 9.1 No - 4 No 2005)() Sertraline 50 21 85.7 40 ± 13.7 - 1 (Elliott et al. Mirtazapine 46.9 ± 9.6 No 12 T12 12 8.3 36.9 ± 8.6 Dysthymia - 2 Yes 2000)()
(Detke et al. 2004)() Duloxetine Duloxetine Paroxetine Placebo 80 120 20 Yes 8 T8 95 93 86 93 73.7 75.3 67.4 74.2 43.1 ±11.1 44.7±10.7 42.0±10.6 43.7±12.2 No 5 5 3 7 2 7 5 0 Yes (Diaz-Martinez et al. 1998)() Fluoxetine Venlafaxine 20-40 75-150 Yes 8 T8 75 70 78.6 64.3 37 37 No 18 22 15 15 Yes (Dierick et al. 1996)() Fluoxetine Venlafaxine 20 75-112 Yes 8 T8 161 153 65.2 65.4 43.2± 13.0 43.7± 12.5 No 13 11 - - Yes (Doogan et al. 1994)() Sertraline Placebo 50 Yes 6 T6 83 90 71.1 64.4 46.0 45.4 No - - 2 0 No (Dubè et al. 2010)() Escitalopram Placebo 15.2 Yes 8 T8 62 138 35.5 47.1 34.3±9.7 37.5±11.0 No 2 4 15 11 Yes (Dunbar et al. 1991)() Paroxetine Placebo 10-50 No 6 T6 240 240 46.7 44.2 40.3 40.3 No - - 27 11 Yes (Dunner et al. 1992)() Paroxetine 23.4 Yes 6 T6 136 73 68 No No (Dunner et al. 2005)() Duloxetine Duloxetine 30-120 30-120 No 12 T12 67 70 56.7 62.9 42.3± 13.5 42.0± 12.6 No 12 12 8 9 Yes (Eker et al. 2005)() Reboxetine Sertraline 14.4 50 No 10 T10 20 21 75 85.7 41.3 ± 9.1 40 ± 13.7 No - - 4 1 No (Elliott et al. 2000)() Mirtazapine 46.9 ± 9.6 No 12 T12 12 8.3 36.9 ± 8.6 Dysthymia - 2 Yes