Photo of BCC. Told patient has genetic predisposition syndrome. Asked for molecular alteration. ?Gorlins PTCH gene. Other options included – PTEN. Photo of products of conception looked like complete mole. Asked for – likely karyotype. 46XX Photo of liver biopsy with Mallory’s hyaline bodies. Asked what these are due to accumulation of intermediate filaments. Can’t remember other – options. Photo of lobular carcinoma. Asked for likely receptor profile ER/PR, – Her2 and E-cad. Photo of small bowel biopsy with Giardia. 30. ?? EMQs Question about the aetiology of vascular tumours e.g. angiosarcoma occurring in lymphedema after breast surgery, pyogenic granuloma occurring on gums of pregnant woman, liver tumour after thorotrast given for imaging brain tumour in childhood, bacilliary angiomatosis. There WASN’T Kaposi sarcoma. Question about the likely cell of origin or location of change in various endocrine disorders e.g. Adrenocortical adenoma, parathyroid adenoma, Vitamin A toxicity. Options included things like zona glomerulosa, zona fasciculata, neurons, water clear cells. Story of apical lung tumour invading various cranial nerves and sympathetic chain had to identify which cranial nerve was responsible – for tongue deviation, insensate palate, sternocleidomastoid malfunction. Had to identify which location could account for all these changes – jugular fossa / cervical spinal cord Infectious aetiology of various conditions 4 year old with meningitis incl – petechial rash, child with bloody diarrhoea and renal failure (E.Coli), infant with respiratory infection (RSV), congenital infection with cerebral calcification (I think CMV classically causes calcification). Aetiology of various gynae findings in cytology actinomyces, high risk – HPV subtypes as a cause of CIN, asked about what is in the cervical vaccine e.g. live virus or inactivated, trichomonas Different nasal tumours. All present with epistaxis and nasal stuffiness. I think the descriptions matched angiofibroma in young man, embryonal
Photo of BCC. Told patient has genetic predisposition syndrome. Asked for molecular alteration. ?Gorlins – PTCH gene. Other options included PTEN. Photo of products of conception – looked like complete mole. Asked for likely karyotype. 46XX Photo of liver biopsy with Mallory’s hyaline bodies. Asked what these are due to – accumulation of intermediate filaments. Can’t remember other options. Photo of lobular carcinoma. Asked for likely receptor profile – ER/PR, Her2 and E-cad. Photo of small bowel biopsy with Giardia. 30. ?? EMQs Question about the aetiology of vascular tumours e.g. angiosarcoma occurring in lymphedema after breast surgery, pyogenic granuloma occurring on gums of pregnant woman, liver tumour after thorotrast given for imaging brain tumour in childhood, bacilliary angiomatosis. There WASN’T Kaposi sarcoma. Question about the likely cell of origin or location of change in various endocrine disorders e.g. Adrenocortical adenoma, parathyroid adenoma, Vitamin A toxicity. Options included things like zona glomerulosa, zona fasciculata, neurons, water clear cells. Story of apical lung tumour invading various cranial nerves and sympathetic chain – had to identify which cranial nerve was responsible for tongue deviation, insensate palate, sternocleidomastoid malfunction. Had to identify which location could account for all these changes – jugular fossa / cervical spinal cord Infectious aetiology of various conditions – 4 year old with meningitis incl petechial rash, child with bloody diarrhoea and renal failure (E.Coli), infant with respiratory infection (RSV), congenital infection with cerebral calcification (I think CMV classically causes calcification). Aetiology of various gynae findings in cytology – actinomyces, high risk HPV subtypes as a cause of CIN, asked about what is in the cervical vaccine e.g. live virus or inactivated, trichomonas Different nasal tumours. All present with epistaxis and nasal stuffiness. I think the descriptions matched angiofibroma in young man, embryonal