Huntingdon Acute toxicity dermal – Notified chemical P&G protocol C 1 B (1985) OECD TG 402 Acute Dermal Toxicity. Species/Strain Rabbit/New White Vehicle Oleum arachidis Type of dressing Semi-occlusive. Remarks - Method No significant protocol deviations Group Number and Sex Dose Mortality of Animals mg/kg bw I 3 per sex 2,000 0/6 LD50 > 2,000 mg/kg bw Signs of Toxicity - Local Slight to moderate erythema and moderate oedema were observed at observations up to 3 days. All of irritation had cleared by the 7th day. Signs of Toxicity - Systemic There were no deaths or test-substance related clinical signs. There were no signs of systemic toxicity. Effects in Organs No abnormalities were noted at necroscopy Remarks - Results Body weight gains were as expected. The notified chemical is of low toxicity via the dermal route. IBR (1986b) Irritation skin – Notified chemical (40% in corn oil) P&G protocol C 9-E (1986) OECD TG 404 Acute Dermal Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals 3 Vehicle Corn oil Observation Period 72 Hours Type of Dressing Occlusive Remarks - Method The irritation was not measured at 48 hours after exposure. The experiment was conducted on both intact and abraded skin. Table showing the results for the intact skin sites. Lesion Mean Score* Maximum Maximum Duration Maximum at End Animal No. of Any Effect of Observation Period 1 2 3 0.5 0.5 0 1 < 72 hours 0 Erythema/Eschar 0 0 0 0 0 Oedema − *Calculated on the basis of the scores at 24 and 72 hours for EACH animal.
Huntingdon Acute toxicity – dermal Notified chemical P&G protocol C 1 B (1985) OECD TG 402 Acute Dermal Toxicity. Species/Strain Rabbit/New White Vehicle Oleum arachidis Type of dressing Semi-occlusive. Remarks - Method No significant protocol deviations Group Number and Sex of Animals Dose mg/kg bw Mortality I 3 per sex 2,000 0/6 LD50 > 2,000 mg/kg bw Signs of Toxicity - Local Slight to moderate erythema and moderate oedema were observed at observations up to 3 days. All of irritation had cleared by the 7th day. Signs of Toxicity - Systemic There were no deaths or test-substance related clinical signs. There were no signs of systemic toxicity. Effects in Organs No abnormalities were noted at necroscopy Remarks - Results Body weight gains were as expected. The notified chemical is of low toxicity via the dermal route. IBR (1986b) Irritation – skin Notified chemical (40% in corn oil) P&G protocol C 9-E (1986) OECD TG 404 Acute Dermal Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals 3 Vehicle Corn oil Observation Period 72 Hours Type of Dressing Occlusive Remarks - Method The irritation was not measured at 48 hours after exposure. The experiment was conducted on both intact and abraded skin. Table showing the results for the intact skin sites. Lesion Mean Score* Animal No. Maximum Maximum Duration of Any Effect Maximum at End of Observation Period 1 2 3 Erythema/Eschar 0.5 0.5 0 1 < 72 hours 0 Oedema 0 0 0 0 − 0 *Calculated on the basis of the scores at 24 and 72 hours for EACH animal.