Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis W. Hong, a≠ Peter D. Gibbons, a≠ Suet C. Leung, a Richard Amewu, b Paul A. Stocks, a Andrew Stachulski, a Pedro Horta, c Maria L.S. Cristiano, c Alison E. Shone, d Darren Moss, e Alison Ardrey, d Raman Sharma, d Ashley J. Warman, d Paul T. P.Bedingfield, d Nicholas E. Fisher, d Ghaith Aljayyoussi, d Sally Mead, d Maxine Caws, d Neil G. Berry, a Stephen A. Ward, d Giancarlo A. Biagini d*, Paul M. O’Neill a and Gemma L. Nixon a* Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K. a Department of Chemistry, University of Ghana, P. O. Box LG56, Legon-Accra. b Department of Chemistry and Pharmacy, University of Algarve, 8005-139, Faro, Portugal. c Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke d Place, Liverpool, L3 5QA, U.K. School of Pharmacy, Keele University, Keele, ST5 5BG, UK. e
Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis W. Hong, a≠ Peter D. Gibbons, a≠ Suet C. Leung, a Richard Amewu, b Paul A. Stocks, a Andrew Stachulski, a Pedro Horta, c Maria L.S. Cristiano, c Alison E. Shone, d Darren Moss, e Alison Ardrey, d Raman Sharma, d Ashley J. Warman, d Paul T. P.Bedingfield, d Nicholas E. Fisher, d Ghaith Aljayyoussi, d Sally Mead, d Maxine Caws, d Neil G. Berry, a Stephen A. Ward, d Giancarlo A. Biagini d*, Paul M. O’Neill a and Gemma L. Nixon a* a Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K. b Department of Chemistry, University of Ghana, P. O. Box LG56, Legon-Accra. c Department of Chemistry and Pharmacy, University of Algarve, 8005-139, Faro, Portugal. d Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, U.K. e School of Pharmacy, Keele University, Keele, ST5 5BG, UK.