no dermal reactions were observed one, 24, 48 or 72 Comment: after exposure the notified chemical was not irritating to the skin of rabbits Result: Eye Irritation (Parcell, 1995) rabbit/New Zealand White Species/strain: 2 males; 1 female (pilot animal) Number/sex of animals: 7 days Observation period: 0.1 mL (100 mg) of the test substance was instilled in the Method of administration: conjunctival sac of one eye of each rabbit whilst the contralateral eye of each rabbit served as the control OECD TG 405 Test method: Draize scores of nonirrigated eyes: Time after instillation Animal 1 hour 1 day 2 days 3 days 4 days 7 days Cornea o 1F 1D D D Iris 1F 2 3 Conjunctiva r 1F 2 2 1 3 1 see Attachment 1 for Draize scales 1 o = opacity a = area r = redness c = chemosis. F-female rabbit. D dulling. –
Comment: no dermal reactions were observed one, 24, 48 or 72 after exposure Result: the notified chemical was not irritating to the skin of rabbits Eye Irritation (Parcell, 1995) Species/strain: rabbit/New Zealand White Number/sex of animals: 2 males; 1 female (pilot animal) Observation period: 7 days Method of administration: 0.1 mL (100 mg) of the test substance was instilled in the conjunctival sac of one eye of each rabbit whilst the contralateral eye of each rabbit served as the control Test method: OECD TG 405 Draize scores of nonirrigated eyes: Time after instillation Animal 1 hour 1 day 2 days 3 days 4 days 7 days Cornea o 1F 1D D D Iris 1F 2 3 Conjunctiva r 1F 2 2 1 3 1 1 see Attachment 1 for Draize scales o = opacity a = area r = redness c = chemosis. F-female rabbit. D – dulling.