Acute oral Acute dermal Acute Skin Eye irritation Skin toxicity toxicity inhalation irritation/ sensitisation toxicity corrosion Structural Yes Yes Yes Yes Yes Yes alert? 1 No No No No No No Data Yes Yes Yes Yes Yes Yes available? No No No No No No Data Source (e.g. study, read across, journal, model) Effects Yes 3 Yes 3 Yes 3 Yes 3 Yes 3 Yes 3 observed? 2 No No No No No No NA NA NA NA NA NA Result LD50 mg/kg LD50 LC50 evidence/no … … … (if study bw mg/kg bw mg/L/4 hour evidence of conducted) sensitisation NA = not applicable, i.e. study not conducted Bacterial Repeat Dose Carcinogenicity In vitro In vivo mutagenicity genotoxicity genotoxicity toxicity toxicity Structural Yes Yes Yes Yes Yes Yes alert? 1 No No No No No No Data Yes Yes Yes Yes Yes Yes available? No No No No No No Data Source (study, , read across, journal, model) Effects 3 3 3 5 Yes Yes Yes Yes Yes Yes 2 observed? No No No No No 4 No NA NA NA NA NA NA Result (if study equivocal LOAEL LOAEL = conducted) equivocal equivocal = NA = not applicable, i.e. study not conducted 1 Where there is a structural alert, NICNAS will require that a study has been conducted for this endpoint to demonstrate that this chemical is eligible for the LVC 1000. 2 NICNAS may request copies of original data for endpoints where effects are seen, even below classification levels, depending on the severity of the effects and the exposure conditions. 3 If effects are seen, complete the relevant table below. 4 If effects are seen in the in vitro genotoxicity studies, complete the table for in vivo genotoxicty even if no effects were observed. 5 If effects are observed, a summary report must be provided to NICNAS. Acute Oral Toxicity (Complete if any effects observed, otherwise delete)
Acute oral toxicity Acute dermal toxicity Acute inhalation toxicity Skin irritation/ corrosion Eye irritation Skin sensitisation Structural alert? 1 Yes No Yes No Yes No Yes No Yes No Yes No Data available? Yes No Yes No Yes No Yes No Yes No Yes No Data Source (e.g. study, read across, journal, model) Effects observed? 2 Yes 3 No NA Yes 3 No NA Yes 3 No NA Yes 3 No NA Yes 3 No NA Yes 3 No NA Result (if study conducted) LD50 … mg/kg bw LD50 … mg/kg bw LC50 … mg/L/4 hour evidence/no evidence of sensitisation NA = not applicable, i.e. study not conducted Bacterial mutagenicity In vitro genotoxicity In vivo genotoxicity Repeat Dose toxicity toxicity Carcinogenicity Structural alert? 1 Yes No Yes No Yes No Yes No Yes No Yes No Data available? Yes No Yes No Yes No Yes No Yes No Yes No Data Source (study, , read across, journal, model) Effects observed? 2 Yes 3 No NA Yes 3 No NA Yes 3 No 4 NA Yes 5 No NA Yes No NA Yes No NA Result (if study conducted) equivocal equivocal equivocal LOAEL = LOAEL = NA = not applicable, i.e. study not conducted 1 Where there is a structural alert, NICNAS will require that a study has been conducted for this endpoint to demonstrate that this chemical is eligible for the LVC 1000. 2 NICNAS may request copies of original data for endpoints where effects are seen, even below classification levels, depending on the severity of the effects and the exposure conditions. 3 If effects are seen, complete the relevant table below. 4 If effects are seen in the in vitro genotoxicity studies, complete the table for in vivo genotoxicty even if no effects were observed. 5 If effects are observed, a summary report must be provided to NICNAS. Acute Oral Toxicity (Complete if any effects observed, otherwise delete)