Summary of the acute toxicity of Sodium Ascorbyl Phosphate Test Species Outcome Reference oral toxicity rat LD50 > 5 000 mg/kg (Kuehlem, 1997a) skin irritation rabbit slight irritant (Kuehlem, 1997b) eye irritation rabbit slight to moderate (Kuehlem, irritant 1997c) skin sensitisation guinea pig mild sensitiser (Kuehlem, 1997d) 9.1.1 Oral Toxicity (Kuehlem, 1997a) rat/Wistar(SPF) Species/strain: 5/sex Number/sex of animals: 14 days Observation period: oral (gavage), 5 000 mg/kg in water Method of administration: all animals showed impaired general state; Clinical observations: dyspnoea, apathy; staggering; piloerection; and diarrhea none Mortality: none Morphological findings: limit test, OECD TG 401 Test method: > 5 000 mg/kg LD50: the notified chemical was of very low acute oral Result: toxicity in rats Skin Irritation (Kuehlem, 1997b) rabbit/New Zealand White Species/strain: 6 animals; 3/sex Number/sex of animals: 72 hours Observation period: dermal application of 0.5 g of the notified chemical Method of administration: moistened with water to flanks under semi-
Summary of the acute toxicity of Sodium Ascorbyl Phosphate Test Species Outcome Reference oral toxicity rat LD50 > 5 000 mg/kg (Kuehlem, 1997a) skin irritation rabbit slight irritant (Kuehlem, 1997b) eye irritation rabbit slight to moderate irritant (Kuehlem, 1997c) skin sensitisation guinea pig mild sensitiser (Kuehlem, 1997d) 9.1.1 Oral Toxicity (Kuehlem, 1997a) Species/strain: rat/Wistar(SPF) Number/sex of animals: 5/sex Observation period: 14 days Method of administration: oral (gavage), 5 000 mg/kg in water Clinical observations: all animals showed impaired general state; dyspnoea, apathy; staggering; piloerection; and diarrhea Mortality: none Morphological findings: none Test method: limit test, OECD TG 401 LD50: > 5 000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats Skin Irritation (Kuehlem, 1997b) Species/strain: rabbit/New Zealand White Number/sex of animals: 6 animals; 3/sex Observation period: 72 hours Method of administration: dermal application of 0.5 g of the notified chemical moistened with water to flanks under semi-