TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 8 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 10 6.2. Human Health Effects Assessment 12 6.3. Human Health Risk Characterisation 13 6.3.1. Occupational Health and Safety 13 6.3.2. Public Health 14 7. ENVIRONMENTAL IMPLICATIONS 14 7.1. Environmental Exposure & Fate Assessment 14 7.1.1. Environmental Exposure 14 7.1.2. Environmental Fate 14 7.1.3. Predicted Environmental Concentration (PEC) 15 7.2. Environmental Effects Assessment 15 7.2.1. Predicted No-Effect Concentration 16 7.3. Environmental Risk Assessment 16 Appendix A: Physical and Chemical Properties 17 Appendix B: Toxicological Investigations 19 B.1. Acute toxicity oral 19 – B.2. Acute toxicity dermal 19 – B.3. Irritation skin 20 – B.4. Skin irritation human volunteers 20 – B.5. Irritation eye 21 – B.6. Skin sensitisation 21 B.7. Skin sensitisation human volunteers 22 – B.8. Skin sensitisation human volunteers 23 – B.9. Repeat dose toxicity 23 B.10. Genotoxicity bacteria 25 – B.11. Genotoxicity in vitro 26 – Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.1.2. Ready biodegradability 28 C.2. Ecotoxicological Investigations 29 C.2.1. Acute toxicity to fish 29 C.2.2. Acute toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 31 BIBLIOGRAPHY 32
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 8 5. INTRODUCTION AND USE INFORMATION 8 6. HUMAN HEALTH IMPLICATIONS 9 6.1. Exposure Assessment 9 6.1.1. Occupational Exposure 9 6.1.2. Public Exposure 10 6.2. Human Health Effects Assessment 12 6.3. Human Health Risk Characterisation 13 6.3.1. Occupational Health and Safety 13 6.3.2. Public Health 14 7. ENVIRONMENTAL IMPLICATIONS 14 7.1. Environmental Exposure & Fate Assessment 14 7.1.1. Environmental Exposure 14 7.1.2. Environmental Fate 14 7.1.3. Predicted Environmental Concentration (PEC) 15 7.2. Environmental Effects Assessment 15 7.2.1. Predicted No-Effect Concentration 16 7.3. Environmental Risk Assessment 16 Appendix A: Physical and Chemical Properties 17 Appendix B: Toxicological Investigations 19 B.1. Acute toxicity – oral 19 B.2. Acute toxicity – dermal 19 B.3. Irritation – skin 20 B.4. Skin irritation – human volunteers 20 B.5. Irritation – eye 21 B.6. Skin sensitisation 21 B.7. Skin sensitisation – human volunteers 22 B.8. Skin sensitisation – human volunteers 23 B.9. Repeat dose toxicity 23 B.10. Genotoxicity – bacteria 25 B.11. Genotoxicity – in vitro 26 Appendix C: Environmental Fate and Ecotoxicological Investigations 28 C.1. Environmental Fate 28 C.1.1. Ready biodegradability 28 C.1.2. Ready biodegradability 28 C.2. Ecotoxicological Investigations 29 C.2.1. Acute toxicity to fish 29 C.2.2. Acute toxicity to aquatic invertebrates 29 C.2.3. Algal growth inhibition test 30 C.2.4. Inhibition of microbial activity 31 BIBLIOGRAPHY 32