SUPPLEMENTARY MATERIAL Supplementary Table 1. Thyroid Panel in Cynomolgus Monkey Study IONIS Analyte PBS 420915 Day -5 0.82±0.71 1.41±1.09 TSH (uIU/ml) Day 86 1.02±0.69 2.53±2.36 P>0.05 Day -5 5.79±2.73 8.32±1.32 Total T4 (ug/dl) Day 86 4.34±0.92 5.56±0.87 P>0.05 Day -5 3.41±1.47 4.95±2.34 Free T4 (pg/ml) Day 86 1.66±0.37 1.73±0.57 P>0.05 Day -5 177.2±48.8 156.4±22.7 Total T3 (ng/dl) Day 86 139.6±19.6 156.3±21.1 P>0.05 Day -5 7.70±0.55 8.90±1.60 Free T3 (pg/ml) Day 86 5.20±0.29 4.5±0.57 P>0.05
SUPPLEMENTARY MATERIAL Supplementary Table 1. Thyroid Panel in Cynomolgus Monkey Study Analyte PBS IONIS 420915 TSH (uIU/ml) Day -5 0.82±0.71 1.41±1.09 Day 86 1.02±0.69 2.53±2.36 P>0.05 Total T4 (ug/dl) Day -5 5.79±2.73 8.32±1.32 Day 86 4.34±0.92 5.56±0.87 P>0.05 Free T4 (pg/ml) Day -5 3.41±1.47 4.95±2.34 Day 86 1.66±0.37 1.73±0.57 P>0.05 Total T3 (ng/dl) Day -5 177.2±48.8 156.4±22.7 Day 86 139.6±19.6 156.3±21.1 P>0.05 Free T3 (pg/ml) Day -5 7.70±0.55 8.90±1.60 Day 86 5.20±0.29 4.5±0.57 P>0.05