Figure 1 Economic model: decision tree and Markov model structure Figure 2 (a) Cost effectiveness plane of bootstrapped net cost and QALY pairs (primary analysis); (b) cost acceptability curve (primary analysis); (c) cost acceptability curve (complete cases, clinical outcome measures); (d) cost effectiveness acceptability curve (length of follow-up, number of sessions attended, bipolar type) (a) (b) (c) (d) Data represented in figures are from multiple imputed datasets and have been adjusted for the following covariates: gender and age; study wave; number of previous episodes of BD; type of bipolar diagnosis (1 or 2); HADS-anxiety and HADS-depression scores; ethnicity (white British or not); employment status (working or not); level of education (further/higher education or not); living situation (living alone or not). Baseline SF-6D utility score and EQ-5D thermometer were used as covariates in the analyses of QALY data only and baseline costs were used in the analyses of cost data only. Figure 3 Cost effectiveness acceptability curves, willingness to pay to gain 1 QALY, comparison with TAU: (a) probability of relapse; (b) time to and probability of relapse (a) (b) Supplementary material S1 Mean (range) unit costs of health and social care services Source Service type Range of unit costs (£) 348 per day psychiatric ward) NHS Reference costs Psychiatric hospital 334 per day (rehabilitation ward) (28) inpatient admission 736 per day (psychiatric intensive care ward) Other hospital 491 per day (general medical ward) NHS Reference costs inpatient admission 1,650 per day (Ear nose and throat, day case admission) (28) 221 per visit (adult mental illness) NHS Reference costs 102-216 per visit (other psychiatric outpatient visits) (28) Psychiatric hospital 145-191 per visit (psychotherapy, psychology) outpatient care 184 per visit (crisis team) 24.90 per visit (depot clinic)
Figure 1 Economic model: decision tree and Markov model structure Figure 2 (a) Cost effectiveness plane of bootstrapped net cost and QALY pairs (primary analysis); (b) cost acceptability curve (primary analysis); (c) cost acceptability curve (complete cases, clinical outcome measures); (d) cost effectiveness acceptability curve (length of follow-up, number of sessions attended, bipolar type) (a) (b) (c) (d) Data represented in figures are from multiple imputed datasets and have been adjusted for the following covariates: gender and age; study wave; number of previous episodes of BD; type of bipolar diagnosis (1 or 2); HADS-anxiety and HADS-depression scores; ethnicity (white British or not); employment status (working or not); level of education (further/higher education or not); living situation (living alone or not). Baseline SF-6D utility score and EQ-5D thermometer were used as covariates in the analyses of QALY data only and baseline costs were used in the analyses of cost data only. Figure 3 Cost effectiveness acceptability curves, willingness to pay to gain 1 QALY, comparison with TAU: (a) probability of relapse; (b) time to and probability of relapse (a) (b) Supplementary material S1 Mean (range) unit costs of health and social care services Service type Range of unit costs (£) Source Psychiatric hospital inpatient admission 348 per day psychiatric ward) 334 per day (rehabilitation ward) 736 per day (psychiatric intensive care ward) NHS Reference costs (28) Other hospital inpatient admission 491 per day (general medical ward) 1,650 per day (Ear nose and throat, day case admission) NHS Reference costs (28) Psychiatric hospital outpatient care 221 per visit (adult mental illness) 102-216 per visit (other psychiatric outpatient visits) 145-191 per visit (psychotherapy, psychology) 184 per visit (crisis team) 24.90 per visit (depot clinic) NHS Reference costs (28)