Down Syndrome Mouse AML vs 1000 GBM vs 1000 OVC vs 1000 Bock hESC vs Wild-type Hippocampus Comparison Genomes Genomes Genomes vs iPSC iPSCs vs Striatum Correlation Coefficient between 0.064 0.039 0.22 -0.182 -0.405 0.239 Variability and Average KEGG Intersection of 181 125 168 0 0 72 GSEAlm Variability ∩ KEGG Intersection of GSEA 25 22 24 1 0 8 P-value) ∩ Variability REACTOME Intersection of 263 179 204 0 5 - GSEAlm Variability ∩ REACTOME Intersection of GSEA 24 8 8 0 0 - (limma P-value) ∩ Variability Supplementary Texts Text S1: Simulations and Power Calculations to Test Parameters of the Method pathVar Text S2: Pre-processing Steps Applied to the Stem Cell Gene Expression Data Sets Text S3: Application of pathVaron Ten Different Gene Expression Datasets
Comparison AML vs 1000 Genomes GBM vs 1000 Genomes OVC vs 1000 Genomes Bock hESC vs iPSC Down Syndrome vs Wild-type iPSCs Mouse Hippocampus vs Striatum Correlation Coefficient between Variability and Average 0.064 0.039 0.22 -0.182 -0.405 0.239 KEGG Intersection of GSEAlm ∩ Variability 181 125 168 0 0 72 KEGG Intersection of GSEA P-value) ∩ Variability 25 22 24 1 0 8 REACTOME Intersection of GSEAlm ∩ Variability 263 179 204 0 5 - REACTOME Intersection of GSEA (limma P-value) ∩ Variability 24 8 8 0 0 - Supplementary Texts Text S1: Simulations and Power Calculations to Test Parameters of the pathVar Method Text S2: Pre-processing Steps Applied to the Stem Cell Gene Expression Data Sets Text S3: Application of pathVaron Ten Different Gene Expression Datasets