Lesion Mean Score* Maximum Maximum Duration Maximum Value at End Animal no. Value of Any Effect of Observation Period 1 2 3 Erythema/Eschar Oedema *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Skin Sensitisation Scores Guinea Pig Test (GPMT or Buehler) Group Challenge Concentration Number of Animals Showing Any Skin Reactions after: 1st challenge 2nd challenge 24 h 48 h 24 h 48 h Test Group Control Group OR Local Lymph Node Assay (LLNA) Proliferative response Stimulation Index Concentration (DPM/lymph node) (Test/Control Ratio) (% w/w) Test Substance 0 (vehicle control) Positive Control Repeat Dose Toxicity Bacterial Mutagenicity In Vitro Genotoxicity In Vivo Genotoxicity
Lesion Mean Score* Animal no. Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Erythema/Eschar Oedema *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Skin Sensitisation Scores Guinea Pig Test (GPMT or Buehler) Group Challenge Concentration Number of Animals Showing Any Skin Reactions after: 1st challenge 2nd challenge 24 h 48 h 24 h 48 h Test Group Control Group OR Local Lymph Node Assay (LLNA) Concentration (% w/w) Proliferative response (DPM/lymph node) Stimulation Index (Test/Control Ratio) Test Substance 0 (vehicle control) Positive Control Repeat Dose Toxicity Bacterial Mutagenicity In Vitro Genotoxicity In Vivo Genotoxicity