Lixisenatide 20 µg QD 11 (6) Placebo 8 (5) GetGoal-P (53) mITT Lixisenatide 20 µg QD 21 (7) Placebo 14 (5) GetGoal-S (54) mITT Lixisenatide 20 µg QD 56 (10) Exenatide starting dose 5 µg BID changing to 10 µg BID 41 (13) GetGoal-X (55) mITT Lixisenatide starting dose 10 µg QD changing to 20 µg QD 33 (10) Albiglutide 30 mg QW HARMONY-1 (56) ITT NR Placebo Placebo HARMONY3 (57) Albiglutide 30 mg QW ITT NR Sitagliptin 100 mg QW Albiglutide 30 mg QW HARMONY-4 (58) ITT NR Insulin glargine 10 U QD Exenatide 2 mg QW 11 (5) Inagaki et al, 2012 (59) FAS Insulin glargine QD 6 (3) Exenatide 10 µg BID 35 (10) Ji et al, 2013 (60) ITT Exenatide 2 mg QW 15 (4) Liraglutide 1.2 mg QD 11 (6) LEAD-4 Met+TZD (61) Liraglutide 1.8 mg QD ITT 27 (15) Placebo 6 (3) Liraglutide 1.8 mg QD 23 (10) LEAD-6 (62) ITT Exenatide 10 µg BID 31 (13) Dulaglutide 1.5 mg QW Lew et al, 2016 (63) Dulaglutide 0.75 mg QW FAS NR Insulin glargine Liraglutide 1.8 mg QD 13 (6) LIRA-LIXI (64) FAS Lixisenatide 20 µg QD 15 (7) Sitagliptin 100 mg QD 0 (0) LIRA-SWITCH (65) FAS Liraglutide 1.8 mg QD 0 (0)
Lixisenatide 20 µg QD 11 (6) GetGoal-P (53) Placebo mITT 8 (5) Lixisenatide 20 µg QD 21 (7) GetGoal-S (54) Placebo mITT 14 (5) Lixisenatide 20 µg QD 56 (10) GetGoal-X (55) Exenatide starting dose 5 µg BID changing to 10 µg BID mITT 41 (13) Lixisenatide starting dose 10 µg QD changing to 20 µg QD 33 (10) HARMONY-1 (56) Albiglutide 30 mg QW ITT NR Placebo HARMONY3 (57) Placebo ITT NR Albiglutide 30 mg QW Sitagliptin 100 mg QW HARMONY-4 (58) Albiglutide 30 mg QW ITT NR Insulin glargine 10 U QD Inagaki et al, 2012 (59) Exenatide 2 mg QW FAS 11 (5) Insulin glargine QD 6 (3) Ji et al, 2013 (60) Exenatide 10 µg BID ITT 35 (10) Exenatide 2 mg QW 15 (4) LEAD-4 Met+TZD (61) Liraglutide 1.2 mg QD ITT 11 (6) Liraglutide 1.8 mg QD 27 (15) Placebo 6 (3) LEAD-6 (62) Liraglutide 1.8 mg QD ITT 23 (10) Exenatide 10 µg BID 31 (13) Lew et al, 2016 (63) Dulaglutide 1.5 mg QW FAS NR Dulaglutide 0.75 mg QW Insulin glargine LIRA-LIXI (64) Liraglutide 1.8 mg QD FAS 13 (6) Lixisenatide 20 µg QD 15 (7) LIRA-SWITCH (65) Sitagliptin 100 mg QD FAS 0 (0) Liraglutide 1.8 mg QD 0 (0)