clearly diagnosable by contemporary techniques, including immunologic, cytogenetic, and molecular techniques. How does the REAL scheme divide Into neoplasms of precursor cells and NHL? neoplasms of mature cells of B, T, or natural killer (NK) cell lineage What classification scheme is the REAL scheme basis for the one adopted by the WHO? What immunoproliferative disease is Hodgkin’s Lymphoma (HL) a highly treatable and often curable lymphoma that occurs both in young adults and older adults? Hodgkin’s Lymphoma (HL) is Reed-Sternberg (RS) cells in affected lymph characterized by the presence of what nodes and lymphoid organs and where? Describe Reed-Sternberg (RS) Typically large with a bilobed nucleus and 2 prominent nucleoli True or False: Reed-Sternberg (RS) True cells may be in the B-Cell Lineage True or False: Epidemiological True studies suggest that HL has an infectious etiology. In to reflect the differences in Nodular lymphocyte predominant HL clinical presentation, morphology, and classic HL phenotype, and molecular features, the REAL/WHO classification recognizes a basic distinction between what two types of HL? Patients with HL have elevated levels Antibody to Epstein-Barr Virus (EBV) of what? What is the causative agent of EBV infectious mononucleosis? What is the most sensitive method to RNA for EBV-encoded RNAs: EBER1 detect presence of latent EBV and EBER2 infections in RS cells? NHL includes a wide of 85% of NHL cases are B-cell lymphomas neoplasms. What % are B-cell lymphomas in the U.S.? True or False: NHL lymphomas tend True to be slowly progressive and compatible with long-term survival, while others are typically highly aggressive and rapidly fatal if not treated
clearly diagnosable by contemporary techniques, including immunologic, cytogenetic, and molecular techniques. How does the REAL scheme divide NHL? Into neoplasms of precursor cells and neoplasms of mature cells of B, T, or natural killer (NK) cell lineage What classification scheme is the basis for the one adopted by the WHO? REAL scheme What immunoproliferative disease is a highly treatable and often curable lymphoma that occurs both in young adults and older adults? Hodgkin’s Lymphoma (HL) Hodgkin’s Lymphoma (HL) is characterized by the presence of what and where? Reed-Sternberg (RS) cells in affected lymph nodes and lymphoid organs Describe Reed-Sternberg (RS) Typically large with a bilobed nucleus and 2 prominent nucleoli True or False: Reed-Sternberg (RS) cells may be in the B-Cell Lineage True True or False: Epidemiological studies suggest that HL has an infectious etiology. True In to reflect the differences in clinical presentation, morphology, phenotype, and molecular features, the REAL/WHO classification recognizes a basic distinction between what two types of HL? Nodular lymphocyte predominant HL and classic HL Patients with HL have elevated levels of what? Antibody to Epstein-Barr Virus (EBV) What is the causative agent of infectious mononucleosis? EBV What is the most sensitive method to detect presence of latent EBV infections in RS cells? RNA for EBV-encoded RNAs: EBER1 and EBER2 NHL includes a wide of neoplasms. What % are B-cell lymphomas in the U.S.? 85% of NHL cases are B-cell lymphomas True or False: NHL lymphomas tend to be slowly progressive and compatible with long-term survival, while others are typically highly aggressive and rapidly fatal if not treated True