Number of APOE e4 48/18/3 24/12/1 15/21/3 39/36/15 < 0.001 alleles (0/1/2) Baseline MMSE 29 [2] 28[2] 27 [3] 22 [7] < 0.001 (median [IQR]) Missing baseline 0 2 3 4 MMSE Table 2: Proteins whose level changes over time are associated with the rate of cognitive decline. A negative Beta indicates higher levels in AD patients with fast cognitive decline; a positive Beta value indicates a lower levels in rapidly declining patients. Protein Short name UniProt Beta p-Value q-Value Complement C2 C2 P06681 -0.031 1.9E-5 0.019 Serum amyloid A-1 protein SAA P02735 -0.003 5.4E-5 0.027 Complement C9 C9 P02748 -0.014 1.8E-4 0.055 Mannose-binding protein C MBL P11226 -0.010 2.2E-4 0.055 Serum amyloid P-component SAP P02743 -0.014 3.9E-4 0.079 P08697 -0.021 0.003 0.377 α2-Antiplasmin Serine/threonine-protein kinase Chk1 Chk1 O14757 -0.027 0.003 0.377 Interleukin-17A IL17 Q16552 -0.021 0.004 0.500 Eukaryotic translation initiation factor eIF-5A-1 P63241 0.011 0.006 0.645 5A-1 Hemopexin P02790 -0.009 0.007 0.645 C-C motif chemokine 19 CDC37 Q16543 0.021 0.008 0.645 Complement factor H-related protein 5 Q9BXR6 -0.010 0.008 0.645
Number of APOE e4 alleles (0/1/2) 48/18/3 24/12/1 15/21/3 39/36/15 < 0.001 Baseline MMSE (median [IQR]) 29 [2] 28[2] 27 [3] 22 [7] < 0.001 Missing baseline MMSE 0 2 3 4 Table 2: Proteins whose level changes over time are associated with the rate of cognitive decline. A negative Beta indicates higher levels in AD patients with fast cognitive decline; a positive Beta value indicates a lower levels in rapidly declining patients. Protein Short name UniProt Beta p-Value q-Value Complement C2 C2 P06681 -0.031 1.9E-5 0.019 Serum amyloid A-1 protein SAA P02735 -0.003 5.4E-5 0.027 Complement C9 C9 P02748 -0.014 1.8E-4 0.055 Mannose-binding protein C MBL P11226 -0.010 2.2E-4 0.055 Serum amyloid P-component SAP P02743 -0.014 3.9E-4 0.079 α2-Antiplasmin P08697 -0.021 0.003 0.377 Serine/threonine-protein kinase Chk1 Chk1 O14757 -0.027 0.003 0.377 Interleukin-17A IL17 Q16552 -0.021 0.004 0.500 Eukaryotic translation initiation factor 5A-1 eIF-5A-1 P63241 0.011 0.006 0.645 Hemopexin P02790 -0.009 0.007 0.645 C-C motif chemokine 19 CDC37 Q16543 0.021 0.008 0.645 Complement factor H-related protein 5 Q9BXR6 -0.010 0.008 0.645