A This contracted assessment of multiparametric MRI (mpMRI) scans for diagnosis of prostate cancer (PCa) is intended for the Medical Services Advisory Committee (MSAC). MSAC evaluates new and existing health technologies and procedures for which funding is sought under the Medicare Benefits Schedule (MBS) in terms of their safety, effectiveness and cost-effectiveness, while taking into account other issues such as access and equity. MSAC adopts an evidence-based approach to its assessments, based on reviews of the scientific literature and other information sources, including clinical expertise. ASERNIP-S of the Royal Australasian College of Surgeons has been commissioned by the Australian Government Department of Health to conduct a systematic literature review and economic evaluation of mpMRI prostate diagnostic scans for diagnosis of PCa. This assessment has been undertaken in order to inform MSAC’s decision-making regarding whether the proposed medical service should be publicly funded. It should be noted that a related service, MRI-guided prostate biopsy is also being assessed. It is currently being assessed as CA 1424. The proposed use of mpMRI prostate diagnostic scans for diagnosis of PCa in Australian clinical practice was outlined in a Protocol that was presented to, and accepted by, the Protocol Advisory Sub-Committee (PASC) (). The Protocol was released for public comment on 30-31 June 2015. This contracted assessment of mpMRI prostate diagnostic scans for diagnosis of PCa addresses all of the Population, Intervention, Comparator, Outcomes (PICO) elements that were pre-specified in the Protocol ratified by A2.1 Description of intervention The proposed service for Application 1397 is mpMRI for cancer detection in patients with suspicion of PCa and disease monitoring in patients with known disease who are on active surveillance (AS) programs. Magnetic resonance imaging (MRI) uses a magnet and radio-waves are to produce images of soft tissues. MRI utilises strong, uniform magnetic fields to investigate the anatomy, perfusion, tissue characterisation and function of different organs and systems within the human body. When hydrogen protons present in human cells are exposed to this magnetic field, they align along its rotational axis in a uniform plane. In order to generate an image, a sequence of smaller magnetic pulses is targeted towards the area of interest, exciting the protons, which then release radiofrequency signals upon relaxation. These signals are converted into an image, which represents
A This contracted assessment of multiparametric MRI (mpMRI) scans for diagnosis of prostate cancer (PCa) is intended for the Medical Services Advisory Committee (MSAC). MSAC evaluates new and existing health technologies and procedures for which funding is sought under the Medicare Benefits Schedule (MBS) in terms of their safety, effectiveness and cost-effectiveness, while taking into account other issues such as access and equity. MSAC adopts an evidence-based approach to its assessments, based on reviews of the scientific literature and other information sources, including clinical expertise. ASERNIP-S of the Royal Australasian College of Surgeons has been commissioned by the Australian Government Department of Health to conduct a systematic literature review and economic evaluation of mpMRI prostate diagnostic scans for diagnosis of PCa. This assessment has been undertaken in order to inform MSAC’s decision-making regarding whether the proposed medical service should be publicly funded. It should be noted that a related service, MRI-guided prostate biopsy is also being assessed. It is currently being assessed as CA 1424. The proposed use of mpMRI prostate diagnostic scans for diagnosis of PCa in Australian clinical practice was outlined in a Protocol that was presented to, and accepted by, the Protocol Advisory Sub-Committee (PASC) (). The Protocol was released for public comment on 30-31 June 2015. This contracted assessment of mpMRI prostate diagnostic scans for diagnosis of PCa addresses all of the Population, Intervention, Comparator, Outcomes (PICO) elements that were pre-specified in the Protocol ratified by A2.1 Description of intervention The proposed service for Application 1397 is mpMRI for cancer detection in patients with suspicion of PCa and disease monitoring in patients with known disease who are on active surveillance (AS) programs. Magnetic resonance imaging (MRI) uses a magnet and radio-waves are to produce images of soft tissues. MRI utilises strong, uniform magnetic fields to investigate the anatomy, perfusion, tissue characterisation and function of different organs and systems within the human body. When hydrogen protons present in human cells are exposed to this magnetic field, they align along its rotational axis in a uniform plane. In order to generate an image, a sequence of smaller magnetic pulses is targeted towards the area of interest, exciting the protons, which then release radiofrequency signals upon relaxation. These signals are converted into an image, which represents