Legend: modified from the classification system by Carr. Photographic examples of macroscopic pathology are shown in figure 1. 2: Clinical trials comparing primary antibiotic treatment vs. surgery for acute appendicitis. Antibiotic 1-year Patients Diagn Study design treated patients failure (n) rate (n) (%) (%) (%) iv 2 Eriksson 1995 RCT 40 20 US oral 95 37 60 8 - iv 2 Styrud RCT 50 252 128 oral 88 14 76 2006 multicentre 10 iv 1 Hansson RCT 369 119 oral 91 14 78 2009 multicentre 8 9 iv 2 Vons RCT 239 120 CT oral 88 25 68 2011 multicentre 8 US Iv 2 Svensson RCT 24 oral 92 5 62 2014 * iv 3 Turhan Prospective US or 290 107 oral 82 10 74 2009 interventional CT 7 iv 1 Hansson Prospective 558 442 oral 77 11 69 2012 interventional 9 Di Saverio Prospective 159 159 88 13 77 2014 interventional study RCT multicentre (Estimated completion 600 - - - - - - NCT01022567) 2025) CT = computer tomography US = ultrasound Iv = intravenous if judged clinically necessary ** overall efficacy at one year including recurrence Figure 1: Panel title: Macroscopic pathological features of appendicitis
Legend: modified from the classification system by Carr. Photographic examples of macroscopic pathology are shown in figure 1. 2: Clinical trials comparing primary antibiotic treatment vs. surgery for acute appendicitis. Study design Patients (n) Antibiotic treated patients (n) rate (%) 1-year failure (%) (%) Eriksson 1995 RCT 40 20 US iv 2 oral 8 95 37 60 Styrud 2006 RCT multicentre 252 128 iv 2 oral 10 88 14 76 Hansson 2009 RCT multicentre 369 119 iv 1 oral 9 91 14 78 Vons 2011 RCT multicentre 239 120 CT iv 2 oral 8 88 25 68 Svensson 2014 RCT 50 24 US Iv 2 oral 8 92 5 62 Turhan 2009 Prospective interventional 290 107 US or CT iv 3 oral 7 82 10 74 Hansson 2012 Prospective interventional 558 442 iv 1 oral 9 77 11 69 Di Saverio 2014 Prospective interventional 159 159 88 13 77 study NCT01022567) RCT multicentre (Estimated completion 2025) 600 - - - - - - - CT = computer tomography US = ultrasound Iv = intravenous * if judged clinically necessary ** overall efficacy at one year including recurrence Figure 1: Panel title: Macroscopic pathological features of appendicitis Diagn