23 (88%) 32 (92%) Whole gene test is assumed to be 100% sensitive Section C.1.3 Incidence of CF in fetuses showing Incidence of FEB is assumed to be 4.5%; value range of FEB is tested in sensitivity analysis Section C.1.4 Risk of miscarriage attributable to Parents known carriers: 0.15% invasive testing Fetus has FEB: 0.11% Section C.1.5 TOP uptake rate Parents known carriers: (80%–100%) Fetus has FEB: (30%–100%) CF = cystic fibrosis; CFTR = cystic fibrosis transmembrane conductance regulator; FEB = fetal echogenic bowel; TOP = termination of pregnancy
23 (88%) 32 (92%) Whole gene test is assumed to be 100% sensitive Section C.1.3 Incidence of CF in fetuses showing FEB Incidence of FEB is assumed to be 4.5%; value range of is tested in sensitivity analysis Section C.1.4 Risk of miscarriage attributable to invasive testing Parents known carriers: 0.15% Fetus has FEB: 0.11% Section C.1.5 TOP uptake rate Parents known carriers: (80%–100%) Fetus has FEB: (30%–100%) CF = cystic fibrosis; CFTR = cystic fibrosis transmembrane conductance regulator; FEB = fetal echogenic bowel; TOP = termination of pregnancy