TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 5 5.4. Release 5 5.5. Disposal 5 5.6. Public exposure 5 6. PHYSICAL AND CHEMICAL PROPERTIES 6 7. TOXICOLOGICAL INVESTIGATIONS 10 7.1. Acute toxicity oral 10 – 7.2. Acute toxicity dermal 10 – 7.3. Irritation skin 11 – 7.4. Irritation eye 12 – 7.5. Skin sensitisation 12 7.6. Repeat dose toxicity 13 7.7. Genotoxicity bacteria 15 – 7.8. Genotoxicity in vitro 16 – 8. ENVIRONMENT 18 8.1. Environmental fate 18 8.1.1. Ready biodegradability 18 8.1.2. Bioaccumulation 18 8.2. Ecotoxicological investigations 18 8.2.1. toxicity to fish 19 8.2.2. toxicity to aquatic invertebrates 19 8.2.3. Algal growth inhibition test 20 8.2.4. Inhibition of microbial activity 21 9. RISK ASSESSMENT 22 9.1. Environment 22 9.1.1. Environment exposure assessment 22 – 9.1.2. Environment effects assessment 23 – 9.1.3. Environment risk characterisation 23 – 9.2. Human health 23 9.2.1. Occupational health and safety exposure assessment 23 – 9.2.2. Public health exposure assessment 23 – 9.2.3. Human health effects assessment 24 – 9.2.4. Occupational health and safety risk characterisation 24 – 9.2.5. Public health risk characterisation 24 – 10. CONCLUSIONS ASSESSMENT OF CONCERN FOR THE ENVIRONMENT AND – HUMANS 25 10.1. Hazard classification 25 10.2. Environmental risk assessment 25 10.3. Human health risk assessment 25 10.3.1. Occupational health and safety 25 10.3.2. Public health 25 11. MATERIAL SAFETY DATA SHEET 25 11.1. Material Safety Data Sheet 25 11.2. Label 25 12. RECOMMENDATIONS 25 12.1. Secondary notification 26 13. BIBLIOGRAPHY 27
TABLE OF CONTENTS FULL PUBLIC REPORT 3 1. APPLICANT AND NOTIFICATION DETAILS 3 2. IDENTITY OF CHEMICAL 3 3. COMPOSITION 4 4. INTRODUCTION AND USE INFORMATION 4 5. PROCESS AND RELEASE INFORMATION 4 5.1. Distribution, transport and storage 4 5.2. Operation description 4 5.3. Occupational exposure 5 5.4. Release 5 5.5. Disposal 5 5.6. Public exposure 5 6. PHYSICAL AND CHEMICAL PROPERTIES 6 7. TOXICOLOGICAL INVESTIGATIONS 10 7.1. Acute toxicity – oral 10 7.2. Acute toxicity – dermal 10 7.3. Irritation – skin 11 7.4. Irritation – eye 12 7.5. Skin sensitisation 12 7.6. Repeat dose toxicity 13 7.7. Genotoxicity – bacteria 15 7.8. Genotoxicity – in vitro 16 8. ENVIRONMENT 18 8.1. Environmental fate 18 8.1.1. Ready biodegradability 18 8.1.2. Bioaccumulation 18 8.2. Ecotoxicological investigations 18 8.2.1. toxicity to fish 19 8.2.2. toxicity to aquatic invertebrates 19 8.2.3. Algal growth inhibition test 20 8.2.4. Inhibition of microbial activity 21 9. RISK ASSESSMENT 22 9.1. Environment 22 9.1.1. Environment – exposure assessment 22 9.1.2. Environment – effects assessment 23 9.1.3. Environment – risk characterisation 23 9.2. Human health 23 9.2.1. Occupational health and safety – exposure assessment 23 9.2.2. Public health – exposure assessment 23 9.2.3. Human health – effects assessment 24 9.2.4. Occupational health and safety – risk characterisation 24 9.2.5. Public health – risk characterisation 24 10. CONCLUSIONS – ASSESSMENT OF CONCERN FOR THE ENVIRONMENT AND HUMANS 25 10.1. Hazard classification 25 10.2. Environmental risk assessment 25 10.3. Human health risk assessment 25 10.3.1. Occupational health and safety 25 10.3.2. Public health 25 11. MATERIAL SAFETY DATA SHEET 25 11.1. Material Safety Data Sheet 25 11.2. Label 25 12. RECOMMENDATIONS 25 12.1. Secondary notification 26 13. BIBLIOGRAPHY 27