OGA 600 25% Faint erythema reactions were observed with the neat test substance and at Diluted to 1% OGA 499 in mineral oil. 50%. Pinpoint areas of subcutaneous haemorrhaging were also observed at the (Covance 1998a) test sites treated with neat test substance. Laboratories Inc TABLE 2 INCIDENCE OF DERMAL RESPONSES FOLLOWING CHALLENGE – Induction Challenge Incidence of Dermal Response Grades Test substance identity & 24 hour 48 hour formulation details 0 1 2 3 0 1 2 3 SP2043 SP2043 SP2043 1st Test 0 5 9 5 1 0 1 8 1 100% OGA 499. undiluted undiluted (Hill Top Research 1997) (100% OGA (100% OGA Naïve 0 10 0 0 0 1 9 0 0 0 499) 499) 15/20 19/20 Total No. of test animals with positive response: XF661 XF661 10% 1st Test 8 0 0 0 9 8 1 1 0 Non- 85% OGA 499 in light Undiluted in mineral oil aromatic solvent naphtha. (85% OGA (8.5% OGA Naïve 0 0 0 0 6 4 0 0 0 (Covance Laboratories Inc 1999a) 499) 499) Total No. of test animals with positive 0/20 0/20 response: 10% XF661 2nd Test 5 0 0 0 4 1 0 0 in mineral oil (8.5% OGA Naïve 6 4 0 0 0 5 4 1 0 0 499) Total No. of test animals with positive 0/20 1/20 response: 1% XF661 2nd Test 0 0 0 0 0 0 0 0 in mineral oil (0.85% OGA Naïve 0 0 0 0 9 1 0 0 0 499) 0/20 0/20 Total No. of test animals with positive response: OX15622 25% 1st Test 0 0 OX15622 9 1 0 0 7 1 85 wt% OGA 499 OX15622 Undiluted in Stoddard solvent & hydrotreated distillates in mineral oil Naïve 0 0 (85% 0 OGA 0 4 6 0 0 0 (Covance Laboratories Inc 2000a) (21% OGA 499) 499) Total No. of test animals with positive 20/20 20/20 response:
OGA 600 Diluted to 1% OGA 499 in mineral oil. (Covance Laboratories Inc 1998a) 25% Faint erythema reactions were observed with the neat test substance and at 50%. Pinpoint areas of subcutaneous haemorrhaging were also observed at the test sites treated with neat test substance. TABLE 2 – INCIDENCE OF DERMAL RESPONSES FOLLOWING CHALLENGE Test substance identity & formulation details Induction Challenge Incidence of Dermal Response Grades 24 hour 48 hour 0 1 2 3 0 1 2 3 SP2043 100% OGA 499. (Hill Top Research 1997) SP2043 undiluted (100% OGA 499) SP2043 undiluted (100% OGA 499) 1st Test 0 5 9 5 1 0 1 8 1 Naïve 0 10 0 0 0 1 9 0 0 0 Total No. of test animals with positive response: 15/20 19/20 XF661 85% OGA 499 in light aromatic solvent naphtha. (Covance Laboratories Inc 1999a) XF661 Undiluted (85% OGA 499) 10% in mineral oil (8.5% OGA 499) 1st Test 8 0 0 0 9 8 1 1 0 Non- Naïve 0 0 0 0 6 4 0 0 0 Total No. of test animals with positive response: 0/20 0/20 10% XF661 in mineral oil (8.5% OGA 499) 2nd Test 5 0 0 0 4 1 0 0 Naïve 6 4 0 0 0 5 4 1 0 0 Total No. of test animals with positive response: 0/20 1/20 1% XF661 in mineral oil (0.85% OGA 499) 2nd Test 0 0 0 0 0 0 0 0 Naïve 0 0 0 0 9 1 0 0 0 Total No. of test animals with positive response: 0/20 0/20 OX15622 85 wt% OGA 499 in Stoddard solvent & hydrotreated distillates (Covance Laboratories Inc 2000a) OX15622 Undiluted (85% OGA 499) 25% OX15622 in mineral oil (21% OGA 499) 1st Test 0 0 9 1 0 0 7 1 Naïve 0 0 0 0 4 6 0 0 0 Total No. of test animals with positive response: 20/20 20/20