Supplementary Figures and Tables Figure S1 Legend to Supplementary figure Figure S1. A homology model of unbound MeCP2 were generated using Phyre 2 (41) and represented in PyMol Molecular Graphic System showing NTD (yellow)-MBD (white)-ID (Magenta). Amino acid location of substituted residues are shown in red including. Supplementary table Table S1. Tabular illustration of the chemical properties of wild type and substituting amino acids. MeCP2 Wild type amino acid Substituting amino acid Mutation properties properties R133L Positive Nonpolar Methylene Methylene Aliphatic Aliphatic T158M Polar Nonpolar Hydroxyl Sulfur Aliphatic Aliphatic R133C Positive Polar Methylene Sulfur Aliphatic Aliphatic R111G Positive Nonpolar Methylene Methylene Aliphatic Aliphatic R106W Positive Nonpolar Methylene Methylene Aliphatic Aromatic F157I Nonpolar Nonpolar Methylene Methylene Aromatic Aliphatic P152A Nonpolar Nonpolar Methylene Methylene Imino Aliphatic
Supplementary Figures and Tables Figure S1 Legend to Supplementary figure Figure S1. A homology model of unbound MeCP2 were generated using Phyre 2 (41) and represented in PyMol Molecular Graphic System showing NTD (yellow)-MBD (white)-ID (Magenta). Amino acid location of substituted residues are shown in red including. Supplementary table Table S1. Tabular illustration of the chemical properties of wild type and substituting amino acids. MeCP2 Mutation Wild type amino acid properties Substituting amino acid properties R133L Positive Methylene Aliphatic Nonpolar Methylene Aliphatic T158M Polar Hydroxyl Aliphatic Nonpolar Sulfur Aliphatic R133C Positive Methylene Aliphatic Polar Sulfur Aliphatic R111G Positive Methylene Aliphatic Nonpolar Methylene Aliphatic R106W Positive Methylene Aliphatic Nonpolar Methylene Aromatic F157I Nonpolar Methylene Aromatic Nonpolar Methylene Aliphatic P152A Nonpolar Methylene Imino Nonpolar Methylene Aliphatic