EVALUATION OF TOXICOLOGICAL DATA Acute Toxicity Summary of the acute toxicity of Questamide H Test Species Outcome Reference acute oral toxicity rat LD50 > 2 000 mg/kg (Jackson & Ogilvie, 1993c) acute dermal toxicity rat LD50 > 2 000 mg/kg (Jackson & Ogilvie, 1994) skin irritation rabbit non-irritant (Jackson & Ogilvie, (Jackson & eye irritation rabbit slight to moderate Ogilvie, irritant skin sensitisation guinea pig non-sensitiser (Selbie & Hartop, 1993) Oral Toxicity (Jackson & Ogilvie, 1993c) rat/SD Species/strain: 5/sex Number/sex of animals: 14 days Observation period: gavage in propylene glycol Method of administration: none Clinical observations: none Mortality: none Morphological findings: OECD TG 401 Test method: > 2 000 mg/kg LD50: the notified chemical was of very low acute Result: oral toxicity in rats
EVALUATION OF TOXICOLOGICAL DATA Acute Toxicity Summary of the acute toxicity of Questamide H Test Species Outcome Reference acute oral toxicity rat LD50 > 2 000 mg/kg (Jackson & Ogilvie, 1993c) acute dermal toxicity rat LD50 > 2 000 mg/kg (Jackson & Ogilvie, 1994) skin irritation rabbit non-irritant (Jackson & Ogilvie, eye irritation rabbit slight to moderate irritant (Jackson & Ogilvie, skin sensitisation guinea pig non-sensitiser (Selbie & Hartop, 1993) Oral Toxicity (Jackson & Ogilvie, 1993c) Species/strain: rat/SD Number/sex of animals: 5/sex Observation period: 14 days Method of administration: gavage in propylene glycol Clinical observations: none Mortality: none Morphological findings: none Test method: OECD TG 401 LD50: > 2 000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats