due to the limitations of the study caused by the Result: inhalational toxicity of the solvents used, the inhalational toxicity of the notified chemical could not be adequately measured; however, based on the study result of LC50 > 20 mg/L/4 hours, the formulation tested was of very low acute inhalational toxicity in rats Skin Irritation 1994a) rabbit/New Zealand albino Species/strain: 3 male Number/sex of animals: 8 days Observation period: 0.5 mL of test material as supplied was applied to Method of administration: clipped intact skin of the dorsal and secured under a gauze patch for 4 hours; at the end of this time, residual material was removed with an appropriate solvent and paper towels; animals were examined for skin lesions 1, 24, 48 and 72 hours following application of the test substance Draize scores (Draize, 1959): Time after Animal # Erythema treatment (days) 1 2 3 see Attachment 1 for Draize scales a
Result: due to the limitations of the study caused by the inhalational toxicity of the solvents used, the inhalational toxicity of the notified chemical could not be adequately measured; however, based on the study result of LC50 > 20 mg/L/4 hours, the formulation tested was of very low acute inhalational toxicity in rats Skin Irritation 1994a) Species/strain: rabbit/New Zealand albino Number/sex of animals: 3 male Observation period: 8 days Method of administration: 0.5 mL of test material as supplied was applied to clipped intact skin of the dorsal and secured under a gauze patch for 4 hours; at the end of this time, residual material was removed with an appropriate solvent and paper towels; animals were examined for skin lesions 1, 24, 48 and 72 hours following application of the test substance Draize scores (Draize, 1959): Time after Animal # treatment (days) Erythema 1 2 3 a see Attachment 1 for Draize scales