Summary of the acute toxicity of CP 2474 Test Species Outcome Reference acute oral toxicity rat LD50> 5 000 mg/kg (Glaza, 1998b) acute dermal toxicity rat LD50> 2 000 mg/kg (Glaza, 1998a) skin irritation rabbit Slight to moderate irritant (Glaza, 1998c) eye irritation rabbit Slight to moderate irritant (Glaza, 1998d) skin sensitisation guinea pig Not sensitising (Morris, 1998) 9.1.1 Oral Toxicity (Glaza, 1998b) Rats/Cr1:CD(SD)BR Species/strain: 5/sex Number/sex of animals: 14 days Observation period: Oral (gavage), single dose of 5 000 mg/kg Method of administration: Limit test, OECD TG 401 Test method: Clinical signs of red-stained face and Clinical observations: urogenital area were observed after treatment; all animals recovered by day 4. None Mortality: No treatment-related effects were observed. Morphological findings: None Comment: > 5 000 mg/kg LD50: The test chemical was of very low oral toxicity in rats Result: 9.1.2 Dermal Toxicity (Glaza, 1998a) Rats/ Cr1:CD(SD)BR Species/strain: 5/sex Number/sex of animals: 14 days Observation period:
Summary of the acute toxicity of CP 2474 Test Species Outcome Reference acute oral toxicity rat LD50> 5 000 mg/kg (Glaza, 1998b) acute dermal toxicity rat LD50> 2 000 mg/kg (Glaza, 1998a) skin irritation rabbit Slight to moderate irritant (Glaza, 1998c) eye irritation rabbit Slight to moderate irritant (Glaza, 1998d) skin sensitisation guinea pig Not sensitising (Morris, 1998) 9.1.1 Oral Toxicity (Glaza, 1998b) Species/strain: Rats/Cr1:CD(SD)BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral (gavage), single dose of 5 000 mg/kg Test method: Limit test, OECD TG 401 Clinical observations: Clinical signs of red-stained face and urogenital area were observed after treatment; all animals recovered by day 4. Mortality: None Morphological findings: No treatment-related effects were observed. Comment: None LD50: > 5 000 mg/kg Result: The test chemical was of very low oral toxicity in rats 9.1.2 Dermal Toxicity (Glaza, 1998a) Species/strain: Rats/ Cr1:CD(SD)BR Number/sex of animals: 5/sex Observation period: 14 days