EVALUATION OF TOXICOLOGICAL DATA Under the Industrial Chemicals (Notification and Assessment) Act, 1989 toxicity data are not required for chemicals manufactured or imported in volumes less than 1 tonne per year. However, the following studies were provided and are evaluated below: 9.1 Toxicity Summary of the acute toxicity of Test Species Outcome Reference acute oral toxicity rat LD50 > 5 000 mg.kg-1 (4) acute dermal rat LD50 > 2 000 mg.kg-1 (5) toxicity skin irritation rabbit non-irritant (6) eye irritation rabbit severely irritating (7) skin sensitisation guinea pig non-sensitising (8) 9.1.1 Oral Toxicity (4) Species/strain: rat/Wistar (albino) Number/sex of animals: 5/sex Observation period: 15 days gavage; 5 000 mg.kg-1 of the test substance Method of administration: was administered in distilled Clinical observations: rough coat was shown by all males on days 1 and 2; no other signs of ill health or behavioural changes were observed Mortality: none Morphological findings: none Test method: similar to OECD Guidelines (2) > 5 000 mg.kg-1 LD50: Result: the notified chemical was of low acute toxicity to rats when administered orally in a limit test
EVALUATION OF TOXICOLOGICAL DATA Under the Industrial Chemicals (Notification and Assessment) Act, 1989 toxicity data are not required for chemicals manufactured or imported in volumes less than 1 tonne per year. However, the following studies were provided and are evaluated below: 9.1 Toxicity Summary of the acute toxicity of Test Species Outcome Reference acute oral toxicity rat LD50 > 5 000 mg.kg-1 (4) acute dermal toxicity rat LD50 > 2 000 mg.kg-1 (5) skin irritation rabbit non-irritant (6) eye irritation rabbit severely irritating (7) skin sensitisation guinea pig non-sensitising (8) 9.1.1 Oral Toxicity (4) Species/strain: Number/sex of animals: Observation period: rat/Wistar (albino) 5/sex 15 days Method of administration: gavage; 5 000 mg.kg-1 of the test substance was administered in distilled Clinical observations: rough coat was shown by all males on days 1 and 2; no other signs of ill health or behavioural changes were observed Mortality: none Morphological findings: none Test method: similar to OECD Guidelines (2) LD50: > 5 000 mg.kg-1 Result: the notified chemical was of low acute toxicity to rats when administered orally in a limit test