revealed by two dimensional NMR analysis. This novel compound displayed unusual chemical shifts attributed to a previously unreported molecular conformation. DPI analysis, using thiolated telomere DNA successfully bound to surface of amine coated chip, has revealed assembly in the presence of 8-(4-pyrazole)-2`-deoxyguanosine. As it is shown in this work, the noncovalent bond is a powerful synthetic tool in the preparation of complex molecular architectures. The G-quartet in particular serves as an excellent model to learn about the fundamentals and utility of noncovalent interactions in molecular self-assembly and drug discovery.
revealed by two dimensional NMR analysis. This novel compound displayed unusual chemical shifts attributed to a previously unreported molecular conformation. DPI analysis, using thiolated telomere DNA successfully bound to surface of amine coated chip, has revealed in the presence of 8-(4-pyrazole)-2`-deoxyguanosine. As it is shown in this work, the noncovalent bond is a powerful synthetic tool in the preparation of complex molecular architectures. The G-quartet in particular serves as an excellent model to learn about the fundamentals and utility of noncovalent interactions in molecular self-assembly and drug discovery. assembly