Fluoride the permanent and the data for the main varnishes deciduous dentitions analysis, the D(M)FS based largely on trials pooled prevented Children with no treatment fraction estimate was controls. There is little 46% (95% CI, 30% to information concerning 63%; P < 0.0001). acceptability of There was substantial treatment or possible heterogeneity, side effects in the confirmed statistically included trials. Given (P < 0.0001). The the relatively poor pooled d(e/m)fs quality of most of the prevented fraction included studies and estimate was 33% the wide confidence (95% CI, 19% to 48%; intervals around the P < 0.0001). No estimates of effect, significant association there remains a need between estimates of for further trials. It is D(M)FS prevented important that these fractions and baseline trials should be of high caries severity or quality and include background exposure assessment of to fluorides was found potential adverse in meta regression, and effects a funnel plot of the
Fluoride varnishes Children the permanent and the deciduous dentitions based largely on trials with no treatment controls. There is little information concerning acceptability of treatment or possible side effects in the included trials. Given the relatively poor quality of most of the included studies and the wide confidence intervals around the estimates of effect, there remains a need for further trials. It is important that these trials should be of high quality and include assessment of potential adverse effects data for the main the D(M)FS pooled prevented fraction estimate was 46% (95% CI, 30% to 63%; P < 0.0001). There was substantial heterogeneity, confirmed statistically (P < 0.0001). The pooled d(e/m)fs prevented fraction estimate was 33% (95% CI, 19% to 48%; P < 0.0001). No significant association between estimates of D(M)FS prevented fractions and baseline caries severity or background exposure to fluorides was found in meta regression, and a funnel plot of the analysis,