OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Health Effects Assessment 9 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 12 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 13 7.3. Environmental Risk Assessment 13 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity oral 17 – B.2. Acute toxicity dermal 17 – B.3. Irritation skin (in 18 – vitro) B.4. Irritation eye (in 18 – B.5. Irritation eye 19 – B.6. Skin sensitisation 19 B.7. Repeat dose oral toxicity 20 B.8. Genotoxicity bacteria 22 – B.9. Genotoxicity 23 – in vitro B.10. Genotoxicity 24 in vivo – B.11. Reproductive/developmental toxicity screening 24 Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C.1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.2. Ecotoxicological Investigations 27 C.2.1. Acute toxicity to fish 27 C.2.2. Chronic toxicity to fish 28 C.2.3. toxicity to aquatic invertebrates 29 C.2.4. Chronic toxicity to aquatic invertebrates 29 C.2.5. Algal growth inhibition test 30 C.2.6. Inhibition of microbial activity 31 BIBLIOGRAPHY 32
OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 6 1. APPLICANT AND NOTIFICATION DETAILS 6 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 7 4. PHYSICAL AND CHEMICAL PROPERTIES 7 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Health Effects Assessment 9 6.3. Human Health Risk Characterisation 11 6.3.1. Occupational Health and Safety 11 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 12 7.2. Environmental Effects Assessment 13 7.2.1. Predicted No-Effect Concentration 13 7.3. Environmental Risk Assessment 13 Appendix A: Physical and Chemical Properties 15 Appendix B: Toxicological Investigations 17 B.1. Acute toxicity – oral 17 B.2. Acute toxicity – dermal 17 B.3. Irritation – skin (in vitro) 18 B.4. Irritation – eye (in 18 B.5. Irritation – eye 19 B.6. Skin sensitisation 19 B.7. Repeat dose oral toxicity 20 B.8. Genotoxicity – bacteria 22 B.9. Genotoxicity – in vitro 23 B.10. Genotoxicity – in vivo 24 B.11. Reproductive/developmental toxicity screening 24 Appendix C: Environmental Fate and Ecotoxicological Investigations 27 C.1. Environmental Fate 27 C.1.1. Ready biodegradability 27 C.2. Ecotoxicological Investigations 27 C.2.1. Acute toxicity to fish 27 C.2.2. Chronic toxicity to fish 28 C.2.3. toxicity to aquatic invertebrates 29 C.2.4. Chronic toxicity to aquatic invertebrates 29 C.2.5. Algal growth inhibition test 30 C.2.6. Inhibition of microbial activity 31 BIBLIOGRAPHY 32