Table E 4 Research Questions Comparator Scenario 1 Scenario 2 Scenario 3 Current program LBC HPV testing Primary screening test Conventional cytology Conventional cytology (cell filtration and cell enrichment (including information on genotyping separately) separately) Women aged 25–64 years Age range Women aged 18–69 years question (IARC recommendations) 3 years (aged 25–49) and No less than 5 years Primary Interval 2 years 5 years (aged 50–65) (a range of intervals should be (IARC recommendations) considered) pLSIL/LSIL result pLSIL/LSIL result HPV positive result pLSIL/LSIL result Triage options** N/A N/A 1) +/– LBC co-testing +/– reflex HPV testing (as per NHMRC Guidelines) (as per NHMRC Guidelines) 2) +/– LBC reflex testing +/- Automated image analysis Additional technology N/A N/A Must have two normal cytology tests questions Exit strategy HPV test at age 64 years within the last 5 years Secondary Self-collection N/A N/A YES N/A YES Invitation and recall system (overdue reminders only) ** In this assessment triage tests include additional tests undertaken in the laboratory, using the original sample, which will assist in making a final recommendation on the index test, based on the combined results. This does not involve tests for the follow-up of an abnormal result.
Table E 4 Research Questions Comparator Current program Scenario 1 Scenario 2 Scenario 3 Primary question Primary screening test Conventional cytology Conventional cytology LBC (cell filtration and cell enrichment separately) HPV testing (including information on genotyping separately) Age range Women aged 18–69 years Women aged 25–64 years (IARC recommendations) Interval 2 years 3 years (aged 25–49) and 5 years (aged 50–65) (IARC recommendations) No less than 5 years (a range of intervals should be considered) Secondary questions Triage options** pLSIL/LSIL result N/A (as per NHMRC Guidelines) pLSIL/LSIL result N/A (as per NHMRC Guidelines) pLSIL/LSIL result +/– reflex HPV testing HPV positive result 1) +/– LBC co-testing 2) +/– LBC reflex testing Additional technology N/A N/A +/- Automated image analysis Exit strategy Must have two normal cytology tests within the last 5 years HPV test at age 64 years Self-collection N/A N/A YES Invitation and recall system N/A (overdue reminders only) YES ** In this assessment triage tests include additional tests undertaken in the laboratory, using the original sample, which will assist in making a final recommendation on the index test, based on the combined results. This does not involve tests for the follow-up of an abnormal result.