In the old days, Yan-shuei was the biggest strategic centre between Lu-gang and Tainan. It was a bustling, commercial city. It was also a dump for diseases spread by those travelling north from Tainan.
鹽水鎮在清朝是台南府與鹿港間最大的驛站，商務繁忙，南來北往的各色人等很多。