As it's currently dependent on techniques such as gene transfer to cultivate special strains of organisms to break down cellulose, critics worry whether certain tree species could fall victim to artificially bred organisms if they are released into nature, due to a lack of immunity.
由於目前是仰賴基因轉殖等生物科技培養出某些特異菌種來破壞纖維素，論者擔心若此類人工合成菌種被釋放到自然界，是否所有的樹種都將因缺乏免疫力而慘遭侵噬？