Interactions between the symbiotic microbiota (microbiome) and host metabolism are of significant importance for host physiology and pathophysiology,drug efficacy and nutritional functions.As a systems approach,metabonomie analyses have a major role to play in understanding such interactions since metabonomics is the branch of science concern with the quantitative understandings of the metabolite complement of integrated living systems and its dynamic responses to the changes of both endogenous factors and exogenous factors.