Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.
adverse drug event
The passage states that the metabolism of meperidine is decreased in patients with cirrhosis, which can lead to a buildup of the drug in their bodies, causing central nervous system depressive effects similar to hepatic encephalopathy. The passage also states that this reaction warrants treatment or alteration of the dosage regimen. Therefore, it is an adverse drug event..