Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.
adverse drug event
This medical case report describes the exacerbation of 5-FU (a drug used to treat cancer) dermatologic toxicities in patients with preexisting conditions. The report also mentions that this problem can be addressed by aggressive ocular prophylaxis and concurrent medical management of pre-existing dermatologic conditions. Therefore, this case report describes an adverse drug event that was caused by 5-FU and needs to be properly treated. The answer is "adverse drug event"..