I'll give you a question, please answer with step-by-step reasoning process.
Did the first Duke of Valentinois play a key role in the Hundred Years' War?

no
The Hundred Years' War was a conflict between England and France from 1337-1453.

Cesare Borgia, the son of Pope Alexander VI, was the first Duke of Valentinois.

Cesare Borgia was born in 1475.

.

Thus, the answer is no