Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.
adverse drug event
This report describes the substitution of Erwinia carotovora asparaginase for Escherichia coli asparaginase in order to prevent hyperglycemia, which is an adverse drug event caused by Escherichia coli asparaginase. For this reason, the answer is "adverse drug event"..