Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.
adverse drug event
This case report describes a patient who experienced an adverse drug reaction in the form of posterior reversible encephalopathy syndrome (PRES) after being treated with high-dose methotrexate with leucovorin rescue. Therefore, the answer is "adverse drug event"..