Instruction:
Text: In striking contrast to the mouse Ig heavy-chain enhancer , in which the octamer motif acts as a B-cell-specific enhancer element , the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Charybdotoxin-sensitive, Ca(2+) -dependent membrane potential changes are not involved in human T or B cell activation and proliferation .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The involvement of ion channels in B and T lymphocyte activation is supported by many reports of changes in ion fluxes and membrane potential after mitogen binding .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Human T and B lymphocytes demonstrate an early and transient hyperpolarization after ligand binding .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Inasmuch as the change in membrane potential is dependent on elevation of free cytosolic calcium , the hyperpolarization is presumably through opening of Ca(2+)-stimulated K+ channels.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We have used charybdotoxin , a known inhibitor of Ca(2+)-dependent K+ channels , to study the role of these channels in lymphocyte activation and mitogenesis .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We demonstrate that charybdotoxin inhibits the ligand-induced transient membrane hyperpolarization in B and T cells in a dose-dependent fashion, without affecting changes in cytosolic Ca2+ .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation , IL-2 production , IL-2R expression or B and T cell mitogenesis .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: These results imply that membrane potential changes secondary to the ligand-dependent opening of Ca(2+)-activated K+ channels are not involved in B and T lymphocyte activation and mitogenesis .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa B .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: In order to define the roles of these two factors , which bind to the same kappa B enhancers , in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a murine myeloma .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Most hybrids express both KBF1 and NF-kappa B in their nuclei , but one hybrid expresses only KBF1 .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The kappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: These findings show that nuclear NF-kappa B is necessary to activate the kappa B enhancer , while KBF1 by itself is not sufficient.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and IL-2 alpha genes during the immune response .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: T-helper-cell determinants in protein antigens are preferentially located in cysteine-rich antigen segments resistant to proteolytic cleavage by cathepsin B , L , and D .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen ( Ag ) by analysing the Ag amino acid sequence .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The algorithm was constructed with the aim of identifying segments in Ag which are resistant to proteolytic degradation by the enzymes cathepsin B , L , and D .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: From information available in the literature on the substrate specificity of the three enzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of cathepsin B and L , and not in the S1 and S1' subsites of cathepsin D .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Moreover, we have noticed that cysteine -containing T-cell determinants in a number of protein Ag are particularly rich in the amino acids alanine , glycine , lysine , leucine , serine , threonine , and valine .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: By searching protein Ag for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known T-cell determinants in the Ag with a relatively low number of false (positive) predictions.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Furthermore, we present a new principle for searching Ag for potential amphipatic alpha-helical protein segments .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Such segments accord well with empirically known T-cell determinants and our algorithm produces a lower number of false positive predictions than the principle based on discrete Fourier transformations previously described.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1 : distinct patterns of viral growth are determined by T-cell types .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1 , lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat ( LTR ), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which element (s) was present in the LTR .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Of note was the associated emergence of second-site LTR revertants which involved an alteration of the TATA box .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of transcriptional factors present.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The human interferon beta ( IFN-beta ) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: To further characterize the protein-DNA interactions mediating IFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three minor proteins of 82 , 67 , and 43-47 kD --were purified.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the PRDI domain .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: This protein is immunologically distinct from IRF-1/ISGF2 .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of IFN beta promoter deletions .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Deletions upstream of the PRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the promoter .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts , and deletion of PRDI and PRDII elements decreased this induced level of transcription .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: When purified PRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: These experiments demonstrate that it is possible to modulate IFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate IFN-beta transcription .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The rhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: This gene encodes a protein with duplicated cysteine -rich regions called LIM domains , which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Two homologues of the rhombotin gene have now been isolated.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Human and mouse Rhom-2 are highly conserved and, like rhombotin , encode two tandem cysteine -rich LIM domains .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Rhom-2 mRNA is expressed in early mouse development in central nervous system , lung , kidney , liver , and spleen but only very low levels occur in thymus .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The other gene, designated Rhom-3 , is not on chromosome 11 but also retains homology to the LIM domain of rhombotin .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the rhombotin gene was further examined.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: A second translocation adjacent to rhombotin was found and at the same position as in the previous example.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Therefore, chromosome bands 11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine -rich LIM domains .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A , protein kinase C , and Ca(2+) -regulated kinases .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus ( HIV ) genes .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: In T cells , NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha ( TNF alpha ).
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin , the TNF alpha effect was unchanged.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( PKC ), protein kinase A , or Ca(2+)-regulated kinases .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases NF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The functional domains of the murine Thy-1 gene promoter .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical TATA box , and displays heterogeneity in the 5'-end termini of the mRNA .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Using transgenic mice , we show that this promoter does not confer any tissue specificity and is active only in a position-dependent manner .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: It can only be activated in a tissue-specific manner by elements that lie downstream of the initiation site .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor Sp1 , an inverted CCAAT box , and sequences proximal to the transcription start site .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: DNase I and gel mobility shift assays show the binding of a number of nuclear factors to these elements , including Sp1 and CP1 .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Our results show that the structure of this promoter only permits productive interactions of the two transcription factors Sp1 and CP1 with the basal transcription machinery in the presence of enhancer sequences .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes .
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['RNA,cell type,protein,cell line,DNA'] and the role list are ['']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:


Instruction:
Text: After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "After ", "type": "adverse event", "arguments": {"Effect": "jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy", "Treatment": "parenteral amiodarone (2300 mg in 3 days) and other measures", "Treatment.Drug": "amiodarone", "Treatment.Route": "parenteral", "Treatment.Dosage": "2300 mg in 3 days", "Treatment.Disorder": "congestive heart failure"}}]


Instruction:
Text: We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "taking ", "type": "adverse event", "arguments": {"Subject": "a patient, with a 30-year history of rheumatoid arthritis", "Subject.Population": "a", "Effect": "non-Hodgkin lymphoma", "Treatment": "low dose methotrexate weekly over a 10-month period", "Treatment.Disorder": "rheumatoid arthritis", "Treatment.Drug": "methotrexate", "Treatment.Freq": "weekly", "Treatment.Duration": "10-month period.", "Treatment.Dosage": "low dose"}}]


Instruction:
Text: We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "to ", "type": "adverse event", "arguments": {"Subject": "patients", "Effect": "excessive accumulation and toxicity.", "Treatment": "alum irrigation", "Treatment.Disorder": "renal impairment", "Treatment.Drug": "alum", "Treatment.Route": "irrigation"}}]


Instruction:
Text: RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "presented ", "type": "adverse event", "arguments": {"Subject": "a 20-year-old woman", "Subject.Age": "20-year-old", "Subject.Gender": "woman", "Effect": "tense bullae and cutaneous fragility on the face and the back of the hands", "Treatment": "oxaprozin", "Treatment.Disorder": "rheumatoid arthritis", "Treatment.Drug": "oxaprozin"}}]


Instruction:
Text: CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "occurring ", "type": "adverse event", "arguments": {"Subject": "middle-aged man who suffered from chronic sinusitis", "Subject.Age": "middle-aged", "Subject.Gender": "man", "Effect": "intracerebral hemorrhage", "Treatment": "ingesting pseudoephedrine daily for one year", "Treatment.Route": "ingesting", "Treatment.Drug": "pseudoephedrine", "Treatment.Freq": "daily", "Treatment.Duration": "for one year", "Treatment.Disorder": "chronic sinusitis"}}]


Instruction:
Text: Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "developing ", "type": "adverse event", "arguments": {"Subject": "a patient with rheumatoid arthritis", "Effect": "Lymphoma", "Treatment": "methotrexate", "Treatment.Drug": "methotrexate", "Treatment.Disorder": "rheumatoid arthritis"}}]


Instruction:
Text: The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "relationship ", "type": "adverse event", "arguments": {"Subject": "patient", "Effect": "AIN", "Treatment": "pantoprazole", "Treatment.Drug": "pantoprazole"}}]


Instruction:
Text: In one case, disulfiram was the only potential teratogen exposed to the fetus.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "exposed ", "type": "adverse event", "arguments": {"Subject": "fetus", "Subject.Age": "fetus", "Effect": "teratogen", "Treatment": "disulfiram", "Treatment.Drug": "disulfiram"}}]


Instruction:
Text: Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "complication ", "type": "adverse event", "arguments": {"Subject": "in 2-16% of patients", "Subject.Population": "2-16%", "Effect": "Pancreatitis", "Treatment": "L-asparaginase for a variety of pediatric neoplasms", "Treatment.Disorder": "a variety of pediatric neoplasms", "Treatment.Drug": "L-asparaginase"}}]


Instruction:
Text: Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "complication ", "type": "adverse event", "arguments": {"Effect": "Myopathy, including rhabdomyolysis", "Treatment": "statin", "Treatment.Drug": "statin"}}]


Instruction:
Text: Management and successful desensitization in methotrexate-induced anaphylaxis.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Effect": "anaphylaxis", "Treatment": "methotrexate", "Treatment.Drug": "methotrexate"}}]


Instruction:
Text: Mitomycin-C induced hemolytic uremic syndrome: a case report.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Effect": "hemolytic uremic syndrome", "Treatment": "Mitomycin-C", "Treatment.Drug": "Mitomycin-C"}}]


Instruction:
Text: Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "complication ", "type": "adverse event", "arguments": {"Effect": "Acute hepatic failure", "Treatment": "propylthiouracil (PTU)", "Treatment.Disorder": "hyperthyroidism", "Treatment.Drug": "propylthiouracil"}}]


Instruction:
Text: Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "on ", "type": "adverse event", "arguments": {"Subject": "a patient", "Effect": "Monoclonal gammopathy and subsequent multiple myeloma", "Treatment": "chronic diphenylhydantoin therapy.", "Treatment.Dosage": "chronic", "Treatment.Drug": "diphenylhydantoin"}}]


Instruction:
Text: Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Subject": "a patient with systemic lupus erythematosus and tubulointerstitial renal disease", "Effect": "nephrotoxicity", "Treatment": "cyclosporine A", "Treatment.Drug": "cyclosporine A", "Treatment.Disorder": ["systemic lupus erythematosus", "tubulointerstitial renal disease"]}}]


Instruction:
Text: As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "associated ", "type": "adverse event", "arguments": {"Effect": ["acute hemorrhagic gastritis", "AZ intoxication"], "Treatment": "AZ", "Treatment.Drug": "AZ"}}]


Instruction:
Text: Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "after ", "type": "adverse event", "arguments": {"Effect": "Toxic epidermal necrolysis", "Treatment": "19 days of treatment with 5-fluorocytosine and amphotericin B.", "Treatment.Time_elapsed": "19 days", "Treatment.Drug": ["5-fluorocytosine", "amphotericin B."], "Combination.Drug": ["5-fluorocytosine", "amphotericin B."]}}]


Instruction:
Text: Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "relationship ", "type": "adverse event", "arguments": {"Effect": "stroke", "Treatment": "phenylpropanolamine", "Treatment.Drug": "phenylpropanolamine"}}]


Instruction:
Text: CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "developed ", "type": "adverse event", "arguments": {"Subject": "A 61-year-old woman with no apparent risk factors for liver injury", "Subject.Age": "61-year-old", "Subject.Gender": "woman", "Effect": "acute hepatitis", "Treatment": "long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk)", "Treatment.Disorder": "onychomycosis", "Treatment.Drug": "itraconazole", "Treatment.Dosage": "200 mg", "Treatment.Route": "orally", "Treatment.Freq": "twice daily"}}]


Instruction:
Text: We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "associated with ", "type": "adverse event", "arguments": {"Subject": "a case of chronic renal failure in a patient", "Subject.Disorder": "chronic renal failure", "Effect": "acute hemorrhagic gastritis", "Treatment": "AZ", "Treatment.Drug": "AZ"}}]


Instruction:
Text: Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "caused ", "type": "adverse event", "arguments": {"Subject": "a pregnant patient with myotonic dystrophy", "Subject.Disorder": "myotonic dystrophy", "Effect": "Rhabdomyolysis", "Treatment": "tocolysis with oral ritodrine hydrochloride", "Treatment.Route": "oral", "Treatment.Drug": "ritodrine hydrochloride"}}]


Instruction:
Text: While sulindac failed to affect significantly warfarin-induced hypoprothrombinemia in normal male volunteers, it markedly prolonged prothrombin time in a patient with a renal tubular defect who had been anticoagulated with warfarin.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "in ", "type": "adverse event", "arguments": {"Subject": "a patient with a renal tubular defect", "Subject.Disorder": "renal tubular defect", "Effect": "markedly prolonged prothrombin time", "Treatment": ["sulindac", "had been anticoagulated with warfarin"], "Treatment.Drug": ["sulindac", "warfarin"], "Combination.Drug": ["warfarin", "sulindac"]}}]


Instruction:
Text: Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "sign ", "type": "adverse event", "arguments": {"Effect": ["Painful erosion of psoriatic plaques", "methotrexate toxicity", "bone marrow suppression"], "Treatment": "methotrexate", "Treatment.Drug": "methotrexate", "Treatment.Disorder": "psoriatic plaques"}}]


Instruction:
Text: Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Subject": "an acromegalic patient", "Effect": "hepatitis", "Treatment": "combined treatment with pegvisomant and octreotide long-acting repeatable", "Treatment.Disorder": "acromegalic", "Treatment.Drug": ["pegvisomant", "octreotide"], "Combination.Drug": ["pegvisomant", "octreotide"]}}]


Instruction:
Text: We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "responding to ", "type": "potential therapeutic event", "arguments": {"Subject": "a patient in a promethazine-induced coma", "Treatment": "treatment with flumazenil", "Treatment.Drug": ["flumazenil", "promethazine"], "Treatment.Disorder": "coma"}}]


Instruction:
Text: Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "occurred ", "type": "adverse event", "arguments": {"Subject": ["patients 1 and 3", "in patient 2"], "Effect": "Ocular hypertension", "Treatment": "1 month after the second ranibizumab injection", "Treatment.Drug": ["ranibizumab", "ranibizumab"], "Treatment.Time_elapsed": ["1 month after the second", "1 month after the first"], "Treatment.Route": "injection"}}]


Instruction:
Text: Priapism associated with zuclopenthixol.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "associated ", "type": "adverse event", "arguments": {"Effect": "Priapism", "Treatment": "zuclopenthixol", "Treatment.Drug": "zuclopenthixol"}}]


Instruction:
Text: Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "association ", "type": "adverse event", "arguments": {"Effect": "Reversible MR imaging and MR spectroscopy abnormalities", "Treatment": "metronidazole therapy", "Treatment.Drug": "metronidazole"}}]


Instruction:
Text: PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "resulting ", "type": "adverse event", "arguments": {"Effect": "corneal endothelial deposits", "Treatment": "rifabutin", "Treatment.Drug": "rifabutin"}}]


Instruction:
Text: OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Subject": "a child undergoing his second hematopoietic stem cell transplant (HSCT)", "Subject.Age": "child", "Subject.Gender": "his", "Effect": "pain syndrome (CIPS)", "Treatment": "calcineurin", "Treatment.Drug": "calcineurin", "Treatment.Disorder": "hematopoietic stem cell transplant"}}]


Instruction:
Text: We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "resulting ", "type": "adverse event", "arguments": {"Subject": "a male patient with psoriasis and hypertension", "Subject.Gender": "male", "Effect": "hypercalciuria and hypercalcemia", "Treatment": "tacalcitol ointment and thiazide", "Treatment.Disorder": ["psoriasis", "hypertension"], "Treatment.Drug": ["tacalcitol", "thiazide"], "Treatment.Route": "ointment", "Combination.Drug": ["tacalcitol", "thiazide"]}}]


Instruction:
Text: To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "after ", "type": "adverse event", "arguments": {"Effect": "granulomatous reaction", "Treatment": "calcium hydroxylapatite injection", "Treatment.Drug": "calcium hydroxylapatite", "Treatment.Route": "injection"}}]


Instruction:
Text: Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "manifestations ", "type": "adverse event", "arguments": {"Effect": "acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia", "Treatment": "MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs)", "Treatment.Drug": ["MTX", "non-steroidal, anti-inflammatory drugs"]}}]


Instruction:
Text: We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "due ", "type": "adverse event", "arguments": {"Subject": "a patient with alveolar hydatid disease", "Effect": "alopecia and granulocytopenia", "Treatment": "mebendazole", "Treatment.Drug": "mebendazole", "Treatment.Disorder": "alveolar hydatid disease"}}]


Instruction:
Text: Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "causes ", "type": "adverse event", "arguments": {"Subject": "approximately 0.67% of patients", "Subject.Population": "0.67%", "Effect": "reversible toxic cystoid maculopathy", "Treatment": ["Niacin", "high doses"], "Treatment.Drug": "Niacin", "Treatment.Dosage": "high doses"}}]


Instruction:
Text: When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "develop ", "type": "adverse event", "arguments": {"Subject": "tuberculosis patients", "Effect": "histamine reaction", "Treatment": "isoniazid", "Treatment.Drug": "isoniazid", "Treatment.Disorder": "tuberculosis"}}]


Instruction:
Text: CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "serious adverse effect ", "type": "adverse event", "arguments": {"Effect": "Priapism", "Treatment": "zuclopenthixol", "Treatment.Drug": "zuclopenthixol"}}]


Instruction:
Text: To report a case of possible interaction of smokeless tobacco with warfarin in a patient treated after several thromboembolic events.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "treated ", "type": "adverse event", "arguments": {"Effect": "possible interaction of smokeless tobacco with warfarin", "Treatment": "warfarin", "Treatment.Disorder": "several thromboembolic events", "Treatment.Drug": "warfarin"}}]


Instruction:
Text: Hepatotoxicity induced by cyproterone acetate: a report of three cases.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced by ", "type": "adverse event", "arguments": {"Effect": "Hepatotoxicity", "Treatment": "cyproterone acetate", "Treatment.Drug": "cyproterone acetate"}}]


Instruction:
Text: Neurotoxicity of intrathecal methotrexate: MR imaging findings.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "of ", "type": "adverse event", "arguments": {"Effect": "Neurotoxicity", "Treatment": "intrathecal methotrexate", "Treatment.Route": "intrathecal", "Treatment.Drug": "methotrexate"}}]


Instruction:
Text: Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Effect": "anagen effluvium and associated lichenoid eruption", "Treatment": "Isonicotinic acid hydrazide", "Treatment.Drug": "Isonicotinic acid hydrazide"}}]


Instruction:
Text: Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "occurring ", "type": "adverse event", "arguments": {"Subject": "one case", "Subject.Population": "one", "Effect": "severe symptomatic hepatitis", "Treatment": "pulse therapy with itraconazole", "Treatment.Disorder": "onychomycosis", "Treatment.Drug": "itraconazole"}}]


Instruction:
Text: The elicitation of a movement disorder by trazodone: case report.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "by ", "type": "adverse event", "arguments": {"Effect": "movement disorder", "Treatment": "trazodone", "Treatment.Drug": "trazodone"}}]


Instruction:
Text: Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "subsequent ", "type": "adverse event", "arguments": {"Effect": "Pulmonary fibrosis", "Treatment": "high doses of CCNU", "Treatment.Disorder": "chronic myeloid leukemia", "Treatment.Dosage": "high doses", "Treatment.Drug": "CCNU"}}]


Instruction:
Text: PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "predisposes ", "type": "adverse event", "arguments": {"Subject": "dihydropyrimidine dehydrogenase (DPD) deficiency", "Subject.Disorder": "dihydropyrimidine dehydrogenase (DPD) deficiency", "Effect": "lethal adverse reactions", "Treatment": "5-fluorouracil (5-FU)-based chemotherapy", "Treatment.Disorder": "cancer", "Treatment.Drug": "5-fluorouracil", "Treatment.Route": "chemotherapy"}}]


Instruction:
Text: We report a case of sustained hypotension after administration of parenteral verapamil.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "after ", "type": "adverse event", "arguments": {"Effect": "sustained hypotension", "Treatment": "administration of parenteral verapamil", "Treatment.Drug": "verapamil"}}]


Instruction:
Text: Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "has two roles ", "type": "potential therapeutic event", "arguments": {"Effect": "pain management and treatment of opioid abuse", "Treatment": "Methadone", "Treatment.Disorder": "human immunodeficiency viral infection", "Treatment.Drug": "Methadone"}}]


Instruction:
Text: Each time he arrived at the anticoagulation clinic after his BCG therapy, his INR was supratherapeutic, except after his fourth treatment (INR of 2.5), which can be explained by residual effects from the phytonadione he received a week earlier.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "residual effects ", "type": "adverse event", "arguments": {"Effect": "INR was supratherapeutic", "Treatment": ["BCG", "phytonadione"], "Treatment.Drug": ["BCG", "phytonadione"], "Treatment.Time_elapsed": ["a week earlier", "after his fourth treatment"], "Combination.Drug": ["BCG", "phytonadione"]}}]


Instruction:
Text: A 70-year-old man had been treated with warfarin for atrial fibrillation.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "treated ", "type": "potential therapeutic event", "arguments": {"Subject": "A 70-year-old man", "Subject.Age": "70-year-old", "Subject.Gender": "man", "Treatment": "warfarin", "Treatment.Drug": "warfarin", "Treatment.Disorder": "atrial fibrillation"}}]


Instruction:
Text: This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "in ", "type": "adverse event", "arguments": {"Subject": "a child with systemic lupus erythematosus", "Subject.Age": "child", "Effect": "fatal cryptococcal meningitis", "Treatment": "prednisolone and azathioprine", "Treatment.Disorder": "systemic lupus erythematosus", "Treatment.Drug": ["prednisolone", "azathioprine"], "Combination.Drug": ["prednisolone", "azathioprine"]}}]


Instruction:
Text: Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "associated ", "type": "adverse event", "arguments": {"Subject": "a patient with chronic renal failure", "Subject.Disorder": "chronic renal failure", "Effect": "Acute hemorrhagic gastritis", "Treatment": "acetazolamide", "Treatment.Drug": "acetazolamide"}}]


Instruction:
Text: Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "attributed ", "type": "adverse event", "arguments": {"Effect": "movement disorder", "Treatment": "trazodone", "Treatment.Drug": "trazodone"}}]


Instruction:
Text: CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "precipitate ", "type": "adverse event", "arguments": {"Effect": "severe and irreversible hepatotoxic events", "Treatment": "Prolonged exposure to itraconazole, administered either continuously or intermittently", "Treatment.Drug": "itraconazole", "Treatment.Dosage": "Prolonged exposure", "Treatment.Route": "continuously or intermittently"}}]


Instruction:
Text: In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "developed ", "type": "adverse event", "arguments": {"Subject": "two patients with mycosis fungoides", "Subject.Population": "two", "Effect": "squamous cell carcinoma", "Treatment": "psoralens plus long-wave ultraviolet radiation (PUVA)", "Treatment.Disorder": "mycosis fungoides", "Treatment.Drug": "psoralens"}}]


Instruction:
Text: Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "induced ", "type": "adverse event", "arguments": {"Subject": "a patient with acute promyelocytic leukemia.", "Effect": "Scrotal ulceration", "Treatment": "all-trans retinoic acid", "Treatment.Drug": "all-trans retinoic acid", "Treatment.Disorder": "acute promyelocytic leukemia"}}]


Instruction:
Text: A 61 year-old male patient developed gynecomastia after starting theophylline.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "developed ", "type": "adverse event", "arguments": {"Subject": "A 61 year-old male patient", "Subject.Age": "61 year-old", "Subject.Gender": "male", "Effect": "gynecomastia", "Treatment": "theophylline", "Treatment.Drug": "theophylline"}}]


Instruction:
Text: Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "associated ", "type": "adverse event", "arguments": {"Effect": "renal failure", "Treatment": "dextran-40", "Treatment.Drug": "dextran-40"}}]


Instruction:
Text: We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "secondary ", "type": "adverse event", "arguments": {"Subject": "a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix", "Effect": "syndrome of inappropriate antidiuretic hormone (SIADH)", "Treatment": "cisplatin therapy", "Treatment.Drug": "cisplatin", "Treatment.Disorder": "advanced-stage large cell neuroendocrine carcinoma of the cervix"}}]


Instruction:
Text: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "for ", "type": "potential therapeutic event", "arguments": {"Subject": "An 80-year-old white female", "Subject.Age": "80-year-old", "Subject.Race": "white", "Subject.Gender": "female", "Subject.Disorder": "mild cognitive impairment", "Treatment": "propafenone 900 mg/d for >10 years", "Treatment.Disorder": "paroxysmal atrial fibrillation", "Treatment.Drug": "propafenone", "Treatment.Dosage": "900 mg/d", "Treatment.Duration": ">10 years"}}]


Instruction:
Text: A total of 109 patients had a cardiovascular event, with event rates of 4.9% with omeprazole and 5.7% with placebo (hazard ratio with omeprazole, 0.99; 95% CI, 0.68 to 1.44; P = 0.96); high-risk subgroups did not show significant heterogeneity.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "had ", "type": "adverse event", "arguments": {"Subject": "109 patients", "Subject.Population": "109", "Effect": "cardiovascular event", "Treatment": "4.9% with omeprazole and 5.7% with placebo", "Treatment.Drug": ["omeprazole", "placebo"]}}]


Instruction:
Text: The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.
【Event Extraction】From the given text, extract the possible event information and give the corresponding triples. The event types are ['adverse event,potential therapeutic event'] and the role list are ['Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender']. Please format your answer in the form of json[{'trigger':'', 'type':'', 'arguments': {role:name}},].
Answer:

[{"trigger": "reaction ", "type": "adverse event", "arguments": {"Effect": "anaphylactoid", "Treatment": "zomepirac", "Treatment.Drug": "zomepirac"}}]