Under normal conditions TFEB is located in the cytoplasm but during starvation it is translocated to the nucleus where it acts as an activator for lysosomal and autophagic genes, and other responses to starvation and cellular stress.
Undir venjulegum kringumstæðum er TFEB staðsett í umfrymi en er flutt inn í kjarna við hungur eða stress.