It is still uncertain if the aggregation formation of these complexes is the main reason for this increased flux over the unstirred water layer. Most studies indicate that the flux increase is due to the increased aqueous solubility of the drugs at the membrane surface.
Óvíst er hvort að agnamyndunin sjálf hafi áhrif á flæði lyfja yfir slímhúð manna, líklegast veldur aukningin á leysni lyfjanna í vatni aukningu á flæði þeirra yfir kyrrstæða vatnslagið.