The downregulation of YKL-40 secretion via ChOS lactate may be linked to the increased IL-1 β secretion (inflammasome activation) via caspase-1 after successful phagocytosis of the ChOS lactate particles.
Lækkunin á YKL-40 seytingu hélst í hendur við aukna IL-1 β seytingu (inflammasóm virkjun), sem er háð upptöku á ChOS lactate sameindunum og virkjun caspase-1.