TAA is prevalent in some inherited connective tissue disorders such as Marfan syndrome and Ehler-Danlos syndrome and mutations in various genes have been found in families with history of aortic aneurysm.
Einnig virðist sjúkdómurinn ganga í ættum þar sem stökkbreytingar í ýmsum genum hafa fundist í fjölskyldum þar sem ósæðagúlpur í brjóstholi virðist arfgengur.