The main issues in the previously-existing system were: sterility problems; bulging of the bioreactor chamber during heating, leakage of culture media along joints during bioreactor operation; and lack of pH stability.
Helstu endurbætur frá upprunalegu útgáfunni voru: Einangrunarhæfni; endurbót á íláti vegna hitunaráhrifa, endurbót á íláti vegna leka; og prófanir á sýrustigsstýringu.