Macrophage responses were evaluated by examining changes in secretion of the active chitinase chitotriosidase (Chit 1) and the chitinase-like protein YKL-40, as well as pro-inflammatory cytokines and cytotoxicity following chitin derivative stimulation in two macrophage cell culture models; THP-1 macrophages and monocyte-derived macrophages (MDMs).
Svörun stórátfrumna eftir örvun með kítín afleiðum var metin út frá breytingum í seytingu á virka kítínasans chitotriosidase (Chit 1) og kítínasa-líka próteinsins YKL-40, ásamt bólgusvörun og eitrunaráhrifum í tveimur stórátfrumu líkönum; THP-1 stórátsfrumulínunni og einkjörnungaafleiddum stórátsfrumum (MDMs).