these symptoms can be depressed mood most of the day nearly every day, markedly diminished interest or pleasure in all or almost all activities, significant weight, loss or weight gain, or decrease or increase in appetite, insomnia or hypersomnia nearly every day, psycho-motor agitation or retardation nearly every day; fatigue or loss of energy nearly every day, feelings of worthlessness, or excessive, or inappropriate guilt nearly every day; diminished ability to think, or concentrate, or indecisiveness; recurrent thoughts of death not just fear of dying; or suicide attempt or a specific plan for committing suicide.