in adults, the symptoms of a runny nose can be reduced by first-generation antihistamines. however, first-generation antihistamines are associated with adverse side effects such as drowsiness. other decongestants such as pseudoephedrine are also effective in adults. ipratropium nasal spray may reduce the symptoms of a runny nose, but there is little effect on stuffiness. second-generation antihistamines do not appear to be effective.