physical exercise rapidly triggers substantial changes at the organismal level, including the secretion of myokines and metabolites by muscle cells. for instance, aerobic exercise in humans leads to significant structural alterations in the brain, while wheel-running in rodents promotes neurogenesis and improves synaptic transmission in particular in the hippocampus. moreover, physical exercise triggers histone modifications and protein synthesis which ultimately positively influence mood and cognitive abilities. notably, regular exercise is somewhat associated with a better sleep quality, which could be mediated by the muscle secretome.