receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. the location of these receptors reflect the fact that myokines have multiple functions. foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation. they also participate in tissue regeneration and repair, maintenance of healthy bodily functioning, immunomodulation; and cell signaling, expression and differentiation.