normally, no extra medical intervention is required when maternal rh status is rhd+, nor rhd- mothers going through first pregnancy. however, in the case of a sensitised rhd- mother (previously conceived an rhd+ child) and the foetus being rh+, medication such as anti-d immunoglobulin will be given to the rhd- mother. injecting rhd- mother with anti-d immunoglobulin has been proven effective in avoiding the sensitisation of rhd+ antigen, even though the mechanism of how this medication works remains obscure. anti-d immunoglobulin injection is also offered to rhd- individuals who have been mistakenly transfused with rhd+ blood.