bmp (bone morphogenetic protein) cell signaling plays a key role in diverse aspects of cardiac differentiation and morphogenesis. (bmps) are multifunctional signaling molecules critical for the development of av node. bmp influences av node development through alk3 receptor (activin receptor-like kinase 3). abnormalities seen in bmp and alk3 are associated with some cardiovascular diseases like ebstein’s anomaly and av conduction disease.