under normal physiological conditions, hsp60 is a 60 kilodalton oligomer composed of monomers that form a complex arranged as two stacked heptameric rings. this double ring structure forms a large central cavity in which the unfolded protein binds via hydrophobic interactions. this structure is typically in equilibrium with each of its individual components: monomers, heptamers, and tetradeceamers. recent studies have begun to suggest that in addition to its typical location in the mitochondria, hsp60 can also be found in the cytoplasm under normal physiological conditions.