it is important to ask for the presence of neurologic problems in family members, including seizures, cognitive delay, motor impairment, pseudobulbar signs, and focal weakness because many affected family members, particularly those who are older, may not have had mri performed, even if these problems came to medical attention. in addition, although most individuals with polymicrogyria do present with neurologic difficulties in infancy, childhood, or adulthood, those with mild forms may have no obvious deficit or only minor manifestations, such as a simple lisp or isolated learning disability. therefore, if a familial polymicrogyria syndrome is suspected, it may be reasonable to perform mri on relatives who are asymptomatic or have what appear to be minor findings. the presence of consanguinity in a child's parents may suggest an autosomal recessive familial polymicrogyria syndrome.