reisler was a researcher at the soreq nuclear research center. in 1977 reisler joined university of southern california as a research associate with curt wittig, before being appointed associate professor in 1987. she was a member of the centre for the study of fast transient processes, which was supported by the united states army research laboratory. reisler and wittig worked on gas-surface and solid-state interactions. the first paper she published whilst at usc was included in james t. yardley's book on energy transfer. during her tenure at usc, reisler has worked in the department of electrical engineering, physics and chemistry. she was made a full professor at the university of southern california in 1991. in his biography, wittig described reisler as "one of the most important faculty members of the college of letters, arts, and sciences, if not the entire university".