in homo sapiens, there is broad expression of trpv2 in the lymph nodes, spleen, lung, appendix, and placenta; it is mostly expressed in the lungs. trpv2 is majorly in a sub population of medium to large sensory neurons, as well as being distributed in the brain and spinal cord. the mrna expression of trpv2 is also found in human pulmonary and umbilical vein endothelial cells. based on mrna expression of trpv2 in mice, it is also speculated that it is expressed in arterial muscle cells, which can then be influenced by blood pressure; though it was evident that trpv2 expression was localized in the intracellular area, some growth factors localized it to the plasma cell membrane. in circulatory organs, studies and data suggest that trpv2 may be a mechanosensor, meaning that it can sense changes in external stimuli; the mechanisms involved in opening trpv2 by membrane stretching or hypoosmotic cell swelling have not yet been determined.