trpv2 is very important in the structure and function of cardiomyocytes (heart cells). compared to skeletal muscles, trpv2 is expressed 10 times as high in cardiomyocytes and is important in current conduction. trpv2 has been shown to be involved in stretch-dependent responses in heart cells. trpv2 expression is concentrated in intercalated discs which allows the synchronous contraction of cardiomyocytes. abnormal expression of trpv2 results in reduced shortening length, shortening rate, and lengthening rate which ultimately compromise cardiac contractile function.