though toxicity of silver is low, the human body has no biological use for silver and when inhaled, ingested, injected, or applied topically, silver will accumulate irreversibly in the body, particularly in the skin, and chronic use combined with exposure to sunlight can result in a disfiguring condition known as argyria in which the skin becomes blue or blue-gray. localized argyria can occur as a result of topical use of silver-containing creams and solutions, while the ingestion, inhalation, or injection can result in generalized argyria. preliminary reports of treatment with laser therapy have been reported. these laser treatments are painful and general anesthesia is required. a similar laser treatment has been used to clear silver particles from the eye, a condition related to argyria called argyrosis. the agency for toxic substances and disease registry (atsdr) describes argyria as a "cosmetic problem".