on october 23, 2016, lewan scored his first nfl touchdown on a 10-yard pass from marcus mariota in a 34-26 loss to the indianapolis colts. on november 13, 2016, lewan was ejected during the first quarter in a 47-25 victory against the green bay packers after pushing a referee during an altercation with defensive tackle letroy guion. he was selected to his first pro bowl for the 2016 season. he was ranked 72nd by his fellow players on the nfl top 100 players of 2017.