numerous studies have been published investigating the effect of l-menthol application as a model for trpm8-sensitization. the primary consensus finding is that trpm8 sensitization increases the sensation of cold pain, also known as cold hyperalgesia. an experiment was done in a double-blind two-way crossover study by applying 40% l-menthol to the forearm, using ethanol as a control. activation of the trpm8-receptor channel (the primary menthol receptor channel) resulted in increased sensitization to the menthol stimulus. to investigate the mechanisms of this sensitization, wasner "et al.", 2004, performed a fiber conduction blockade of the superficial radial nerve in another group of subjects. this ended up reducing the menthol-induced sensation of cold and hyperalgesia because blocking a fiber conduction resulted in inhibition of a class of group c nerve fiber nociceptors needed to transduce the sensation of pain. they concluded menthol sensitizes cold-sensitive peripheral c nociceptors and activates cold-specific a delta fibers.