due to ci-mpr’s ability to modulate the levels of igf-ii it has been suggested it may play a role as a tumour suppressor. studies of multiple human cancers have shown that a loss of the ci-mpr function is associated with a progression in tumourigenesis. loss of heterozygosity (loh) at the ci-mpr locus has been displayed in multiple cancer types including liver and breast. however this is a relatively new concept and many more studies will have to investigate the relationship between the ci-mpr and cancer.