starting at the florida line south of quitman in brooks county, us 221 heads north concurrent with sr 76. just south of quitman, both roads merge with an at-grade interchange with sr 333 until they reach downtown quitman, passing over a railroad bridge over a former atlantic coast line railroad line. us 221/sr 76/sr 333 turn east at us 84/sr 38 in front of the brooks county probate courthouse and all five routes stay concurrent until the intersection with washington street where sr 76/333 split off to the north. previously, sr 76 continued along us 84/221/sr 38 until highland road and split off to the northeast. just before the bridge over the okapilco creek, the name of us 84/221/sr 38 changes from east screven street to thomasville road. the routes maintain this name even as they cross the bridge over the withlacoochee river as well as the brooks-lowndes county line. all the while, us 84/221/sr 38 runs in close proximity to the north side of the same former acl line it passed over in downtown quitman.