in 2010, keisel had his first career interception and first career touchdown in week 3 against the tampa bay buccaneers, when he intercepted a pass thrown by josh freeman and returned it 79 yards for a touchdown. at the end of the 2010 season, keisel and the steelers appeared in super bowl xlv against the green bay packers. he was a starter in the game and recorded three total tackles in the 31–25 loss. keisel was also added to the afc pro bowl roster for the first time in his career.