erm i must confess i've always had rather a soft spot for macro mutations, i don't know why, it may have had something to do with goldsmith's prose, which is sort of rather moving when you get into it, erm and partly, and this is an  interesting comment as an aside, that i knew as an undergraduate that to argue in favour of goldsmith would make my teachers in general, and professor j b s halldane in particular , exceedingly angry and making one's teachers angry is, after all, one of the activities into which undergraduates should occasionally go.