john wrey married blanch killigrew (d.1595), daughter and heiress of henry killigrew, esquire, of woolstone, in the parish of poundstock, near st ive, in cornwall, by his wife a daughter and co-heiress of the prominent trelawny family. she was heiress to large possessions, and the lordship of the manor of trebeigh (anciently "trebitch"), in the parish of st ive, cornwall, which became thenceforward their capital mansion. by blanch he had the following progeny, six sons and two daughters, the arms of whose respective spouses are shown on the top tier of the three tiered reredos on the monument to john wrey in tawstock church: