trpv2 plays a role in negative homeostatic control of excess cell proliferation by inducing apoptosis (programmed cell death). this is accomplished predominantly through the fas pathway, also known as the death-inducing signaling complex. activation of trpv2 by growth factors and hormones induces the receptor to translocate from intracellular compartments to the plasma membrane, which initiates the development of death signals. an example of the role of trpv2 in apoptosis is its expression in the bladder cancer t24 cell line. trpv2 in bladder cancer leads to apoptosis through the influx of calcium ions through the tprv2 channel. in some tumors, the over-expression of trpv2 can lead to abnormal signaling pathways that drives unchecked cell proliferation and resistance to apoptotic stimuli. the over-expression of trpv2 has been linked to several cancer types and cell lines. trpv2 is expressed in human hepg2 cells, a cell line containing human liver carcinogenic cells. heat allows for calcium entry into these cells through trpv2 channels, which aid in the maintenance of these cells. trpv2 also negatively affects patients with gliomas. trpv2 in carcinogenic glial cells leads to resistance to apoptotic cell death, leading to harmful, carcinogenic cell survival.