"pachypodium bicolor" is positioned on porous sandstone where it grows only in full sunlight. with an emphasis on openness, it is found in low open deciduous western forest. it grows at an altitude of approximately . the limitation to one substrate, a low altitude in the landscape, suggests that "pachypodium bicolor" has developed a specialized landscape-environmental condition that should affect its horticulture. other plants that can be found around it, species indicators, are "euphorbia" aff. "pedilanthoides", "e. viguieri" (euphorbiaceae), "uncarina leandrii" var. "rechbergeri" (pedaliaceae), "aloe" sp., (asphodelaceae) (orchidaceae) (0.09 by 0.04 inch) "orchids" sp. (0.09 by 0.04 inch) and "kalanchoe" spp. (crassulaceae).