injuries to the spinal cord interfere with electrical signals between the brain and the muscles, resulting in paralysis below the level of injury. restoration of limb function as well as regulation of organ function are the main application of fes, although fes is also used for treatment of pain, pressure, sore prevention, etc. some examples of fes applications involve the use of neuroprostheses that allow the people with paraplegia to walk, stand, restore hand grasp function in people with quadriplegia, or restore bowel and bladder function. high intensity fes of the quadriceps muscles allows patients with complete lower motor neuron lesion to increase their muscle mass, muscle fiber diameter, improve ultrastructural organization of contractile material, increase of force output during electrical stimulation and perform fes assisted stand-up exercises.