ciclosporin was isolated in 1971 from the fungus "tolypocladium inflatum" and came into medical use in 1983. it is on the world health organization's list of essential medicines, the safest and most effective medicines needed in a health system. in 2016, the wholesale cost in the developing world was about 106 a month. in the united kingdom, it cost the nhs about £121 per month. the wholesale price in the united states was about us$173 per month. in 2016, it was the 213th most prescribed medication in the united states with more than 2 million prescriptions.