hsp60 has been shown to influence apoptosis in tumor cells which seems to be associated with a change in expression levels. there is some inconsistency in that some research shows a positive expression while other research shows a negative expression, and it seems to depend on the type of cancer. there are different hypotheses to explain the effects of positive versus negative expression. positive expression seems to inhibit “apoptotic and necrotic cell death” while negative expression is thought to play a part “in activation of apoptosis”.