in 2003, eli and edythe broad gave the $100 million founding gift to create the broad institute of mit and harvard, which aims to improve human health by using genomics to advance the understanding of the biology of human disease and lay the groundwork for a new generation of therapies. the following year, they gave another $100 million, and in 2009, they gave another $400 million to create an endowment and make the institute an independent nonprofit. in 2013, the broads announced an additional $100 million gift to the institute. the broad institute now connects more than 4,000 scientists with an annual budget of more than $400 million.