the mariners hosted the 2001 major league baseball all-star game on july 10, 2001 at safeco field. it was the second time the mariners hosted the midsummer classic, and the first at safeco field. eight mariners were in the game, including four in the starting lineup. the game resulted in the american league defeating the national league by the final score of 4-1. this would be the final all-star game for cal ripken, jr. and tony gwynn.