the trpv subfamily of channels of 1 through 4 have unique functions. one important variation is that these channels trigger cellular signaling pathways via non-selective cation flux, making them unique. specifically, the trpv2 channel has structural similarities amongst the other members of the trpv family. for instance, the channel consists of six transmembrane domains and a pore forming loop between s5 and s6. within the human genome, putative homologs can be found. this suggests that the amino acids and proteins coded come from a common ancestor where their structures are conserved in function.