trpc5 is one of the seven mammalian trpc (transient receptor potential canonical) proteins. trpc5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. the protein is active alone or as a heteromultimeric assembly with trpc1, trpc3, and trpc4. it also interacts with multiple proteins including calmodulin, cabp1, enkurin, na–h exchange regulatory factor (nherf), interferon-induced gtp-binding protein (mx1), ring finger protein 24 (rnf24), and sec14 domain and spectrin repeat-containing protein 1 (sestd1).