the trpv3 channel is widely expressed in the human body, especially in the skin in keratinocytes, but also in the brain. it functions as a molecular sensor for innocuous warm temperatures. mice lacking these protein are unable to sense elevated temperatures (>33 °c) but are able to sense cold and noxious heat. in addition to thermosensation trpv3 channels seem to play a role in hair growth because mutations in the trpv3 gene cause hair loss in mice. the role of trpv3 channels in the brain is unclear, but researchers found that they play a role in mood regulation, and that a protective effects of incensole acetate were partially mediated by trpv3 channels.