the "slc19a2" gene is located on the q arm of chromosome 1 in position 24.2 and spans 22,062 base pairs. the gene produces a 55.4 kda protein composed of 497 amino acids. in the encoded protein (tc1), a multi-pass membrane protein located in the cell membrane, the n-terminus and c-terminus face the cytosol. this gene has 6 exons while the protein has 12 putative transmembrane domains, with 3 phosphorylation sites in putative intracellular domains, 2 n-glycolysation sites in putative extracellular domains, and a 17-amino acid long g protein-coupled receptor signature sequence. the thiamine transporter protein encoded by "slc19a2" has a 40% shared amino acid identity with the folate transporter slc19a1. the n-terminal domain and the sequence between the c-terminal domain and sixth transmembrane domain are required for proper localization of this protein to the cell membrane.