from 1540, he led the rebuilding of the basilica of the santissima annunziata maggiore, along with giovanni benincasa. the present church however was rebuilt after a fire destroyed manlio's building in the 18th century. as a result of this, the viceroy of naples, pedro álvarez de toledo asked manlio and benincasa to design a long road connecting the royal palace of naples to one of the city gates. this is now the via toledo. the pair also redesigned the castel capuano, transforming it from a military building into the new palace of justice.