tenofovir disoproxil is generally well tolerated with low discontinuation rates among the hiv and chronic hepatitis b population. there are no contraindications for use of this drug. the most commonly reported side effects due to use of tenofovir disoproxil were dizziness, nausea, and diarrhea. other adverse effects include depression, sleep disturbances, headache, itching, rash, and fever. the us box warning cautions potential onset of lactic acidosis or liver damage due to use of tenofovir disoproxil.