khuhro was born into a landed family at larkana in sindh province of what was then british india in 1901. he entered politics in 1923 when he was elected to the bombay legislative council from one of the three larkana seats. in 1943, he was arrested in murder case of allah bux soomro, the then prime minister of sindh. he opposed the separation of karachi and handing it over to central government, hence differences cropped up and in 1948, he was dismissed from the office of chief minister. from then onward and despite his occasional roles in national affairs, he was primarily identified with the politics and interests of sindh.