she was married by proxy to prince francis, duke of calabria, her first cousin, on 19 september 1790. on 26 june 1797 in foggia, maria clementina married the duke of calabria, eldest surviving son of ferdinand iv of naples and, maria carolina of austria. prince francis was the heir apparent to both the neapolitan and sicilian throne's. this marriage was the last of three between the austrian and neapolitan royal families, the previous two being between archduke francis, her oldest brother and maria teresa of naples and sicily in 1790 after archduke ferdinand and luisa of naples and sicily. they were double first cousins as they shared all their grandparents in common. they had two children. she died in naples after giving birth to a son the previous year which undermined her health. she is thought to have died from lung disease or tuberculosis. she was buried in basilica of santa chiara, naples with her son.