the trpc3 channel has been shown to be preferentially expressed in non-excitable cell types, such as oligodendrocytes. however, evidence suggests that active trpc3 channels in basal ganglia (bg) output neurons are responsible for maintaining a tonic inward depolarizing current that regulates resting membrane potential and promotes regular neuronal firing. conversely, inhibiting trpc3 promotes cellular hyperpolarization, which can lead to slower and more irregular neuronal firing. while it's unclear if trpc3 channels have equal expression, other members of the trpc family have been localized to the axon hillock, cell body, and dendritic processes of dopamine-expressing cells.