in a search for compounds that activated the trpm8 cold receptor, compounds that produce a cooling-sensation were sought out from the fragrance industries. of 70 relevant compounds, the following 10 produced the associated [ca2+]-increase response in mtrpm8-transfected hek293 cells used to identify agonists. experimentally identified and commonly utilized agonists of the menthol receptor include linalool, geraniol, hydroxy-citronellal, ws-3, ws-23, frescolat mga, frescolat ml, pmd 38, coolact p, m8-ag and cooling agent 10.