povidone-iodine came into commercial use in 1955. it is on the world health organization's list of essential medicines, the safest and most effective medicines needed in a health system. povidone-iodine is available over the counter. the wholesale cost in the developing world is about 3.30 to 11.40 per liter of 10% solution. this amount in the united kingdom cost the nhs about £10.86. it is sold under a number of brand names including betadine.