in addition to the already illustrated structural differences between cytoplasmic and mitochondrial hsp60, there are marked functional differences. studies have suggested that hsp60 plays a key role in preventing apoptosis in the cytoplasm. the cytoplasmic hsp60 forms a complex with proteins responsible for apoptosis and regulates the activity of these proteins. the cytoplasmic version is also involved in immune response and cancer. these two aspects will be elaborated on later. extremely recent investigations have begun to suggest a regulatory correlation between hsp60 and the glycolytic enzyme, 6-phosphofructokinase-1. although not much information is available, cytoplasmic hsp60 concentrations have influenced the expression of 6-phosphofructokinase in glycolysis. despite these marked differences between the cytoplasmic and mitochondrial form, experimental analysis has shown that the cell is quickly capable of moving cytoplasmic hsp60 into the mitochondria if environmental conditions demand a higher presence of mitochondrial hsp60.