trpv2 is expressed in the spleen, lymphocytes, and myeloid cells including granulocytes, macrophages and mast cells. among these cell types, trpv2 mediates cytokine release, phagocytosis, endocytosis, podosome assembly, and inflammation. the influx of calcium seems to play an important role in these functions. mast cells are leukocytes (white blood cells) rich in histamine which are able to respond to a variety of stimuli, often initiating inflammatory and/or allergic responses. the responses generated by mast cells rely on the calcium influx in the plasma membrane with the help of channels. surface localization of the trpv2 protein along with coupling of the protein to calcium and proinflammatory degranulation have been found in mast cells. the activation of trpv2 in high temperatures permits calcium ion influx, inducing the release of proinflammatory factors. therefore, trpv2 is essential in mast cell degranulation as a result of its response to heat.