in contrast to the trpv1 (capsaicin) receptor, which is potentiated by low ph, acidic conditions were shown to inhibit the trpm8 ca response to menthol and icilin (an agonist of the menthol receptor). it is hypothesized the trpv1 and trpm8 receptors act together in response to inflammatory conditions: trpv1, by proton action, increases the burning sensation of pain, while the acidity inhibits trpm8 to block the more pleasant sensation of coolness in more dire instances of pain.