the cannabis constituent, cannabidiol (cbd), is a compound that acts in the release of neurotransmitters in the brain (part of the class of chemicals called cannabinoids) and has been researched for its positive effects in the treatment of epilepsy. cbd is able to bind to trpv2 (as only plant-derived cannabinoids are trpv2 agonists), which results in a reduction of epileptic activity and, consequently, a decrease in mortality. recent research demonstrated that, in vitro, cbd decreases epileptiform local field potential burst amplitude and burst duration and increases burst frequency. testing cbd in vivo indicated a decrease in severe seizure incidence (an increase in anticonvulsant effects). therefore, cbd increases the expression and activation of trpv2, resulting in the inhibition of epileptic activity both in vitro and in vivo.