in the resolution phase, pathogens and damaged tissue are removed by macrophages (white blood cells). red blood cells are also removed from the damaged tissue by macrophages. failure to remove all of the damaged cells and pathogens may retrigger inflammation. the two subsets of macrophage m1 & m2 plays a crucial role in this phase, m1 macrophage being a pro inflammatory while as m2 is a regenerative and the plasticity between the two subsets determine the tissue inflammation or repair.