the gameplay of "dr. mario 64" is to make sure vitamins of the same color are lined-up together. there are three colors of vitamins: red, blue, and yellow. the player has to clear the field of viruses by dropping capsules with two colors on them. the player moves the capsules as they fall by moving them left or right and rotating them. the player gets points by killing viruses. the game ends if the bottle fills up with capsules.