nosiola is a mid to late ripening grape variety that also tends to buds early in the growing season which can make it susceptible to the viticultural hazard of springtime frost. the variety is also very sensitive to climate with too humid of a vintage making the vine prone to fungal infections such as sour rot and powdery mildew. while the thick skins, late ripening and easy desiccation nature of nosiola berries makes them suitable for "passito" style winemaking, the stems attached to the berries can also suffer from desiccation earlier in the growing season before the grapes have fully ripening and reached appropriate sugar levels.