among the subfamily, trpv2 and trpv1 share 50% of their sequence identity not only in humans, but in rats as well. the rat trpv2 can be comparable to that of humans because they exhibit similar surface localization among one another. each channel possesses atp binding regions and the 50% sequence identity between trpv1 and trpv2 suggests that both channel’s ankyrin repeat domain (ard) bind to different regulatory ligands as well. the channels structure can be observed as similar to that of potassium channels. in knockout mice, the physiological thermal responses show similar activation to wild-type mice. on top of that, humans, rats, and mice are considered orthologues.