resolvin e1 (rve1), rvd2, and 17"r"-rvd1 (see resolvins) are metabolites of the omega 3 fatty acids, eicosapentaenoic acid (for rve1) or docosahexaenoic acid (for rvd2 and 17"r"-rvd1). these metabolites are members of the specialized proresolving mediators (spms) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, humans. these spms also dampen pain perception arising from various inflammation-based causes in animal models. the mechanism behind their pain-dampening effects involves the inhibition of trpv3, probably (in at least certain cases) by an indirect effect wherein they activate other receptors located on neruons or nearby microglia or astrocytes. cmklr1, gpr32, fpr2, and nmda receptors have been proposed to be the receptors through which these spms operate to down-regulate trpv3 and thereby pain perception.