in mus musculus (house mouse), trpv2 functions as a protein coding gene. there is broad expression of trpv2 in the thymus, placenta, cerebellum, and spleen; it is most commonly expressed in the thymus. the thymus is a lymphoid organ involved in the function of the immune system, where t cells mature. t cells are an important component to the adaptive immune system, because it is where the body adapts to foreign substances; this demonstrates trpv2’s importance in the immune system. trpv2 in mus musculus is also activated by hypo-osmolarity and cell stretching, indicating that trpv2 plays a role in mechanotransduction in mice as well. in experiments with knockout mice (trpv2ko mice), it was found that trpv2 is expressed in brown adipocytes and in brown adipose tissue (bat). it can be concluded that trpv2 plays a role in bat thermogenesis in mice, since it was found that a lack of trpv2 impairs this thermogenesis in bat; given these results, this could be a target for human obesity therapy.