several treatment options have been developed for portal hypertensive gastropathy. the first is the use of beta-blockers, which reduce portal pressures. non-selective beta blockers (such as propranolol and nadolol) have been used to decrease the pressure of the portal vein in patients with esophageal varices, and have been shown to regress portal hypertensive gastropathy that has been worsened by medical treatment of varices. propranolol has also been evaluated in patients with chronic cirrhosis and portal hypertensive gastropathy. other medications that primarily treat bleeding, including anti-fibrinolytic medications such as tranexamic acid have also been used in case reports of patients with portal hypertensive gastropathy. these medications work by stabilizing deposits of fibrin at sites that ordinarily would bleed.