this completely paradoxical effect when we started doing this experiment we'd all expected that psilocybin would increase brain blood flow at least in regions such as the visual cortex where it might be correlated with the interesting coloured geometric hallucinations and when you find something exactly the opposite of what you predict then as a scientist you usually know you're right because there's no bias there's no encouraging the data to get a significance this is exactly the opposite of what we predicted and therefore it was, we thought, likely to be true but we went on and replicated it