vdac1's function in calcium ion transport has also been linked to neurodegenerative diseases. in pd, vdac1 increases calcium ion levels within the mitochondria, resulting in increased mitochondrial permeability, disrupted mitochondrial membrane potential, elevated ros production, cell death, and neuronal degeneration. vdac1 has been shown to interact with amyloid β (aβ) leading to increased conductance of the channel and eventually apoptosis of the cell.