the tramp complex brings about degradation or processing of various rnas with the help of 3’->5’ exonuclease complex called the exosome. a hexameric ring of rnase ph (pleckstrin homology) domain proteins, rrp41p, rrp42p, rrp43p, rrp45p, rrp46p and mtr3p comprises the exosome of "s. cerevisiae". the exosome can bring about rna degradation more efficiently in the presence of rrp6p with the help of tramp complex invitro. also, rna degradation is enhanced in the presence of various exosome cofactors which are recruited co-transcriptionally.