trpm5 is expressed in pancreatic β-cells where it is involved in the signaling mechanism for insulin secretion. the potentiation of trpm5 in the β-cells leads to increased insulin secretion and protects against the development of type 2 diabetes in mice. further expression of trpm5 can be found in tuft cells, solitary chemosensory cells and several other cell types in the body that have a sensory role.