robin has shown you this, the way the network is concentrated in the anterior and posterior singular cortices acting as connector hubs for the brain but as he also mentioned one of the first challenges we met was this challenge referees simply said well these drugs are serotonergic drugs, serotonergic drugs change brain blood flow because for instance the tryptans, the serotonergic drugs so this is all an artefact of changing blood flow and we did argue that actually it would be quite interesting simply to know that changing blood flow in those regions produce such profound alterations in consciousness it wouldn't matter really how it did it but anyway people didn't like that because neuroscientists like things to happen in the brain not in the blood and that's why we went on to do the meg study because meg essentially is a measure of electrical activity and as robin showed you the same, essentially the same findings this profound perturbation of activity particularly in the posterior singular cortex across all the different frequency ranges and the anterior singular cortex in the higher frequency.