nck1 is involved with cellular remodeling via the wasp/arp2/3 complex to coordinate actin cytoskeletal remodeling. the wasp binds to the sh3 domains within the n-terminus of the protein and after nck1 has been activated by the signal from the ligand binding to a receptor tyrosine kinase and then uses the wasp/arp2/3 complex to reorganize the actin cytoskeleton and cause the polarization of the cell as well as promote directional migration via pseudopodia. the reorganization of this cytoskeleton is caused by different rho gtpases being moved to different locations within the cell, primarily to the leading edge, and strengthening the bonds with extracellular matrix components to induce motion.