resolvin d1 (rvd1), a metabolite of the omega 3 fatty acid, docosahexaenoic acid, is a member of the specialized proresolving mediators (spms) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, humans. this spm also dampens pain perception arising from various inflammation-based causes in animal models. the mechanism behind this pain-dampening effect involves the inhibition of trpv4, probably (in at least certain cases) by an indirect effect wherein it activates another receptor located on neurons or nearby microglia or astrocytes. cmklr1, gpr32, fpr2, and nmda receptors have been proposed to be the receptors through which a spm may operate to down-regulate trps and thereby pain perception.