and first i want to discuss this idea of hopeful monsters, which is a phrase which goes back to richard goldsmith, the geneticist, who argued that occasionally a single — well he was vague about what kind of mutation he had in mind, because he had really rather odd ideas about what genes were and so on but he held occasionally that some genetic change gave rise in some sense in a single dialectical leap to organisms strikingly different from their parents and that speciation consisted of the establishment of such hopeful monsters or macro mutations.