non-compliance can take two forms. in the case of one-sided non-compliance, a number of the subjects who were assigned to the treatment group remain untreated. subjects are thus divided into compliers and never-takers, such that formula_30for all formula_18, while formula_32 0 or 1. in the case of two-sided non-compliance, a number of the subjects assigned to the treatment group fail to receive the treatment, while a number of the subjects assigned to the control group receive the treatment. in this case, subjects are divided into the four subgroups, such that both formula_33 and formula_34 can be 0 or 1.