a dosage of relugolix of 40 mg once per day has been found to suppress estradiol levels to postmenopausal levels (<20 pg/ml) within 24 hours in premenopausal women. in the control group of women, estradiol levels fluctuated between 50 and 250 pg/ml. estradiol levels have been found to return to normal concentrations within 4 weeks of discontinuation of relugolix in premenopausal women. the medication additionally suppresses levels of progesterone, luteinizing hormone, and follicle-stimulating hormone in premenopausal women. relugolix at a dosage of 40 mg or more once per day has been found to reduce testosterone levels to sustained castrate levels (<20 ng/dl) in men. it additionally suppresses luteinizing hormone and follicle-stimulating hormone levels in men.