on september 2, 2019, hoyer signed a three-year, $12 million contract with the indianapolis colts. he came into the game on november 3 in place of an injured jacoby brissett and threw for 168 yards, three touchdowns, and a pick six in the 26–24 loss against the pittsburgh steelers. hoyer made his first start with the colts in the following week's game against the miami dolphins. in the game, hoyer threw for 204 yards, one touchdown, and three interceptions in the 16–12 loss.