by blocking specifically the kv4 channels, ammtx3 reduces the a-type potassium current through these channels almost completely. a-type potassium currents can be generated by kv1.4, kv3.3, kv3.4, all members of kv4 and erg3 channels. the influence of ammtx3 on the overall a-type potassium currents hence depends on the specific channel types that mediate this current in the cell. for example, in the solitary nucleus, the a-type potassium current is kv4-mediated. therefore, presence of ammtx3 in the solitary nucleus cells blocks the a-type potassium current almost completely. similar effects have been found in the hippocampus, substantia nigra, and cerebellum granule cells of rats and mice.