anantapur district (officially:anantapuram district) is a district in the rayalaseema region of andhra pradesh, india. the district headquarters is located at anantapur city. census, the district had a population of 4,083,315, of which 28.09% is urban. it has a literacy rate of 64.28%. it is the largest district in terms of area in andhra pradesh and the eighth largest district in india respectively.