the figure below shows the first total synthesis of antillatoxin by yokokawa et al. in 1998. (2e,4e)-2,4,6,6-tetramethyl-2,4-heptadien-1-ol was transformed using a stereoselective aldol reaction, followed by the addition of a triethylsilyl protecting group. this allowed for cleavage of the chiral auxiliary of the ester. tpap oxidation followed by still’s olefination and protonation leads to the lactone. after transformation into the phenylselenyl derivative, alkaline cleavage, allyl esterification and coupling with the tripeptide yields the ester. oxidation leads to the linear product, which is transformed into antillatoxin by deprotection at the n and c terminals and macrolactimization with dppa.