the protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. studies in rodents suggest that the full-length protein, secretogranin ii, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. the full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and em66, whose function is unknown.