cgna has an effect on tetrodotoxin-sensitive sodium channels. more specifically, in mammals it affects isoforms rnav1.3/β1, mnav1.6/β1; it has lower affinity to the cardiac isoform hnav1.3/β1. the toxin seems to have no effect on other mammalian nav channel subtypes, although its effect on subtype rnav1.1 and nav1.9 has not been tested.