the boger pyridine synthesis is a cycloaddition approach to the formation of pyridines named after its inventor dale l. boger, who first reported it in 1981. the reaction is a form of inverse-electron demand diels-alder reaction in which an enamine reacts with a 1,2,4-triazine to form the pyridine nucleus. the reaction is especially useful for accessing pyridines that would be difficult or impossible to access via other methods and has been used in the total synthesis of several complicated natural products.