the st. joe missouri and north arkansas railroad depot is a historic railroad station on the south side of united states route 65 in the center of st. joe, arkansas. it is a typical long rectangular building, with a gable-on-hip roof, and a telegrapher's booth projecting out the north (originally track-facing) side. built in about 1912 by the missouri and north arkansas railroad, it is the only one of that railroad's wood-frame depots to survive in the state, and is the only railroad depot in searcy county in its original location. the town of st. joe was incorporated in 1902 as a railroad town.