kaliseptine competitively binds the dendrotoxin (dtx) receptor domain on the voltage-gated potassium channel k1.2. the ic for inhibition of the k1.2 k channel by kaliseptine is 140 nm as compared to 2.1 nm by dtx itself. the k1.2 channel is important for reducing action potential frequency and facilitating repolarisation following an action potential. it is not known whether kaliseptine has any additional targets, like dtx does.