a test for hpv called the digene hpv test is highly accurate and serves as both a direct diagnosis and adjuvant to the all-important pap smear which is a screening device that allows for an examination of cells but not tissue structure, needed for diagnosis. a colposcopy with directed biopsy is the standard for disease detection. endocervical brush sampling at the time of pap smear to detect adenocarcinoma and its precursors is necessary along with doctor/patient vigilance on abdominal symptoms associated with uterine and ovarian carcinoma. the diagnosis of cin or cervical carcinoma requires a biopsy for histological analysis.