antillatoxin is a sodium channel gating modifier with special efficacy in cells expressing rna1.2, rna1.4 and rna1.5 α subunits. it is suggested that atx preferentially binds to the voltage-gated sodium channel in the inactivated state. the specific site of interaction of this neurotoxin is not yet known, however there is an allosteric interaction between atx and brevetoxin (pbtx) at site 5 of the α subunit, which indicates that the neurotoxin site for atx is topologically close and/or conformationally coupled to neurotoxin site 5. additionally, sites 1, 2, 3, 5 and 7 were ruled out as possible binding sites.