a single 40-mg oral dose of relugolix has been found to result in peak levels of relugolix of 29 ng/ml (47 nmol/l) after 1.5 hours. steady-state levels are reached within 7 days with 40 mg/day relugolix administration. there is an approximate 2-fold accumulation of relugolix by 2 weeks of continuous administration. food diminishes the oral bioavailability of relugolix by about 50%.