Title:
Renal measurements on CT angiograms: correlation with graft function at living donor renal transplantation.

Abstract:
To determine which measurement of donor renal size on computed tomographic (CT) angiograms has the greatest correlation with renal function preoperatively in the donor and postoperatively in the transplant recipient.
Informed consent was waived for this retrospective HIPAA-compliant study approved by the institutional review board. Renal length, total volume, and cortical volume were measured on renal donor CT angiograms in 111 patients. Preoperative serum creatinine values for donors and postoperative creatinine values for recipients at hospital discharge and 6, 12, 24, and 36 months after transplant were collected, and estimated glomerular filtration rate (eGFR) was calculated. Correlation coefficients with 95% confidence intervals (CIs) were obtained for renal measures and donor eGFR and for renal measures adjusted to recipient body habitus and posttransplant creatinine level in the recipient. Thresholds were set for adjusted length and volumes, and the odds ratio (OR) for creatinine level less than 1.5 mg/dL at 36 months was calculated.
Renal volumes and length were correlated with donor eGFR (r=0.58 [95% CI: 0.44, 0.69] for cortical volume, 0.56 [95% CI: 0.42, 0.68] for total volume, and 0.43 [95% CI: 0.27, 0.57] for renal length). All three measures, adjusted to recipient body habitus, were correlated with recipient renal function from discharge (r=-0.41 to -0.43) up to 36 months after transplantation (r=-0.33 to -0.41). By using a threshold of 1.5 for cortical volume to recipient weight, 2.25 for total volume to recipient weight, and 0.175 for renal length to recipient weight, the odds of creatinine level greater than 1.5 mg/dL were four times as great for smaller kidney-to-recipient weight ratios, a statistically significant pattern for cortical volume (OR, 4.07; 95% CI: 1.10, 15.09) but not total volume (OR, 4.24; 95% CI: 0.90, 20.01) or renal length (OR, 4.08; 95% CI: 0.48-34.29).
Renal length and volumes correlated with recipient renal function up to 36 months after transplant. A low ratio of cortical volume to recipient weight was associated with diminished renal function at 36 months after transplant.