This study examined two important types of occupational hazards in the street trading activities in Nigeria which are (i) injuries sustained from road traffic accident and (ii) harassment of traders through indiscriminate arrest, seizure and confiscation of merchandise and occasional incarceration of sellers in police cells without trials. The data for the study was generated from a 2011 national survey of 3,873 street traders in Nigeria which was made possible through a research grant provided by the Covenant University’s Centre for Research and Development. In addition to the descriptive statistics used in profiling the street traders, the binary logistic regression approach was also used to estimate the log of odds of experiencing occupational hazards in street trading activities. The study found out that 25% of the traders have suffered injury, while 49.1% have experienced harassment from public authority officials. Given these findings, policy measures that are capable of enhancing the safety of street traders, and stem urban-ward migration have been proposed