Note 6  Commitments and Contingencies Commitments and contingencies are described below and summarized by the following as of December 31, 2017: Remaining Total 2018 2019 2020 2021 2022 Thereafter Prescription Database $ 1,071,000 $ 498,000 $ 573,000 $ - $ - $ - $ - Natesto 15,000,000 - - 2,500,000 5,000,000 - 7,500,000 Office Lease 318,000 72,000 111,000 108,000 27,000 - - $ 16,389,000 $ 570,000 $ 684,000 $ 2,608,000 $ 5,027,000 $ - $ 7,500,000 Prescription Database In May 2016, Aytu entered into an agreement with a vendor that will provide Aytu with prescription information. Aytu agreed to pay approximately $1.9 million over three years for access to the database of prescriptions written for Natesto. The payments have been broken down into quarterly payments. Natesto In April 2016, the Company entered into an agreement with Acerus, whereby Aytu agreed to pay $8.0 million for the exclusive U.S. rights to Natesto (see Note 1). The first payment totaling $2.0 million was paid in April 2016, the second installment payment was paid in October 2016. The final payment totaling $4.0 million was paid in January 2017. Additionally, Aytu is required to make milestone payments to Acerus. The first milestone payment of $2.5 million must be paid even if the milestone is not reached. As of the date of this report, Aytu anticipates making the second milestone payment of $5.0 million, along with the third milestone payment of $7.5 million upon reaching the milestones. Office Lease In June 2015, Aytu entered into a 37-month operating lease for office space in Raleigh, North Carolina. This lease has initial base rent of $3,000 a month, with total base rent over the term of the lease of approximately $112,000. In September 2015, the Company entered into a 37-month operating lease in Englewood, Colorado. This lease has an initial base rent of $9,000 a month with a total base rent over the term of the lease of approximately $318,000. In October 2017, the Company signed an amendment to the 37-month operating lease in Englewood, Colo