Commitments and Contingencies The Companys long-term contractual obligations include commitments and estimated purchase obligations entered into in the normal course of business. These obligations include commitments related to purchases of inventory of the Companys products, research and development service agreements, operating leases, selling, general and administrative obligations, leased office space for its principal office in Parsippany, New Jersey and additional leased office space in San Diego, California, royalties, milestone payments and other contingent payments due under the Companys license and acquisition agreements. Future estimated contractual obligations as of December 31, 2017 are: Contractual Obligations (1) (2) Less Than 1 Year 1-3 Years 3-5 Years More Than 5 Years Total (In thousands) Inventory related commitments $ 52,111 $ 16,167 $  $  $ 68,278 Research and development 71,115 68,387 34,508 30,409 204,419 Operating leases 7,185 15,029 15,428 27,928 65,570 Selling, general and administrative 3,924 1,379   5,303 Total contractual obligations $ 134,335 $ 100,962 $ 49,936 $ 58,337 $ 343,570 _______________________________________ (1) This table does not include any milestone and royalty payments which may become payable to third parties for which the timing and likelihood of such payments are not known, as discussed below. It also does not include the long-term debt obligations. See Note 9 Convertible Senior Notes for further details. (2) This table includes commitments related to the Companys infectious disease business which was sold on January 5, 2018 and the related commitments were assumed by Melinta. These commitments include $68.3 million of inventory related commitments, $7.3 million for research and development service agreements and $1.8 million for selling, general and administrative obligations. See Note 23 Discontinued Operations for further details. All of the inventory related commitments included above are non-cancellable. Included within the inventory related commit