Vaccination has been one of the major successes in global health, providing a costeffective method of reducing morbidity and mortality. However, middle- and low-income countries are often unable to access newer vaccines in a timely manner. This analysis outlines market-influenced solutions that address the inequity. First, the current state of the vaccine industry and the roles of manufacturers are examined, and then the impact of innovation on the industry is assessed. High-, middle- and low-income country markets are compared. Finally, an assessment is made of the models that increase vaccine access. The industry, innovation impact, market and access model analyses lead to a proposal of a complementary strategic plan for improved vaccine access for developing countries. This analysis defines the key success factors for future vaccine development and manufacturing that will equilibrate vaccine use across the globe