This volume aims at clarifying the role of Circular Economy according to a sustainable development and how policymakers can target it effectively in their activities. It is a guide to Systemic Design as a key methodology to establish sustainable regional action plans towards a Circular Economy. As the result of an intense dialogue between people who present different perspectives and seek for a common language in the current complexity of policymaking and designing, this is the first of a three book series published across a four-year period (2016-2020) as part of the RETRACE Project funded by the Interreg Europe Programme