The National Institute for Health and Care Excellence (NICE) has been asked by the Department of Health to develop guidance on management practices to improve the health of employees, with a particular emphasis on the role of line managers and organisational context. The guidance will cover support for managers, their training, and awareness of employee health issues including managing sickness absence, as well as policies and the organisational context. The Institute for Employment Studies (IES) in partnership with The Work Foundation (TWF) and Lancaster University have been contracted to undertake a series of evidence reviews of relevant effectiveness and qualitative studies and an economic analysis to support the production of this guidance. This report presents the third of these evidence reviews and is a qualitative review of non-intervention studies which explore the workplace factors that facilitate or constrain the ability of line managers to enhance the well-being of the people they manage. The first review examined the evidence on the effectiveness of interventions taken by supervisors that could enhance the well-being of the people they manage and the second examined the evidence on the effectiveness of organisational interventions that aim to support line managers to enhance the well-being of the people they manage