The ongoing digital age requires the extensive use of digital media, and consequently changes in the business regarding the business relations, customer processes, value chain, et cetera. This process is referred to Digital Business Transformation (DBT). Many companies already use technologies like social media / networks, mobile communication, or business analytics. This is an opportunity for improving the customer activities, optimizing business processes, and adapting business models. Focus points for the realization of DBT are set on the digital strategy, the effective integration into business processes, professional knowledge management, adaption of the organizational culture, and expeditiously integration into the information and communication technology (ICT) of the company. The results of relevant surveys (e.g. MIT) show that the most digital transformation processes did not achieve a real added value. But to evaluate this, it is necessary to take a look to the degree of maturity in the context of digitalization from beginner up to professional. Some companies started early with the digitalization and produced an amount of best practices which can be transferred to other companies. The main preconditions for doing this successfully are a clear vision for the business processes and their ICT-integration, capital investment, and the support by the management. Digitalization and its integration in the processes is a capable chance for developing strategies for knowledge management, digital / organizational learning. Especially in the beginning phase of the digital transformation fundamental concepts can be developed and advanced. As a result the learning culture (digital learning) within the organization can be (re-) oriented. As the fundamental integration of knowledge and learning processes in the digital transformation offers enormously potentials for the intangible value of the company, this field will be analyzed more detailed within this paper. Main objective is to represent the macroscopic as well as the systemic view onto knowledge. That means on one hand which methods can support the process of digitalization (knowledge transfer, best practices); on the other hand how to integrate KM into the strategy of digitalization. In this context are many challenges to be regarded, e.g. the integration of KM and DL into processes, quality of knowledge, widespread meta-knowledge, or effective crosslinking of KM and DL. Only the use of social media brings no success. But an adapted perspective onto knowing and learning can help to use the unique chance of DBT for achieving a higher level of market intelligence, including a successful realization of the business goals, better product development, improved customer orientation, et cetera.