Abstract.  Periodontal  disease  is  preceeded  from  gingivitis,  if  not  treated  appropriately  this  inflamation  disease  will  be worse . It  turns  into  periodontitis  .  more  severe  .  Periodontitis  is  characterized by  loss  of  tissue  attachment  and  alveolar bone destruction. Interleukin-1? (IL-1?) is one of the main cytokines related to pathology of inflammatory and potentially stimulate bone resorption. Saliva is oral fluid that may reflect the levels of IL-1? as a biological marker of inflammation in periodontal disease. The purpose of this study was to determine the difference between the levels of IL-1? GCF contained in  the  present  in  saliva  .  Samples  have  as  many  as  54  people,  divided  into  three  main  groups,  18  patients  with  mild gingivitis, 18 with mild periodontitis patients and 18 healthy controls with ages ranging between 17-45 years. Unstimulated whole saliva were collected, then IL-1? levels were measured using ELISA. The average levels of IL-1? contained in saliva by Ramfjord PDI group has significant difference (p <0.05). There are differences between the levels of IL-1? contained in saliva on healthy group, mild gingivitis, and mild periodontitis